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Conserved domains on  [gi|1774526357|gb|QGH34030|]
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HAMP domain-containing protein [Gracilibacillus salitolerans]

Protein Classification

methyl-accepting chemotaxis protein( domain architecture ID 11435591)

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

CATH:  1.10.287.950
Gene Ontology:  GO:0006935
PubMed:  18165013|20738376
SCOP:  4003862

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
17-567 7.52e-81

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


:

Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 263.03  E-value: 7.52e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357  17 LILSVVLGLFLISTIVVAFFLDDVQSEIEAMERRGDRAVNVTEMGSLIRAKGIRVFQYMEDPTSEVVNEFNQRKDLFKRL 96
Cdd:COG0840    14 LLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357  97 KDDLAEDLSNSEAKTLVEQVVELDEAFNLEFNEVISYVGQGDLEMAAHHADQAHNIQreVVQILEELQELVAADRLIAVN 176
Cdd:COG0840    94 ALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLAL--ALLAAAAAAAAALAALLEAAA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 177 EAKKSQTMAISALIIAIAVSLIISIILIIIVNRIVSRNLNKVVDVSNSIADGNLLVDsIDYHANDEIGQLSRSINKMSTN 256
Cdd:COG0840   172 LALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVR-IDVDSKDEIGQLADAFNRMIEN 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 257 LRKIIQQVSTVSDTVSAQSEELNQSSnevrsgtgqiastmQELASGAETQANHAGDVASKMSDFSQKVHEADENGEKIEG 336
Cdd:COG0840   251 LRELVGQVRESAEQVASASEELAASA--------------EELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAE 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 337 ASTKVLNMAENGSEMMNSSVAQMGRIHTIVQDAVEKVRGLDNQSQEITKLVAVIKDIAEQTNLLALNAAIESARAGEHGK 416
Cdd:COG0840   317 LAEEASELAEEGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGR 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 417 GFAVVADEVRKLAEQVAVSVTDITGIVTNIQSESSNVSQSLEEGYSEVEVGSEQIENTGKTFEQINTAVTDMVSSITTVT 496
Cdd:COG0840   397 GFAVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIA 476

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1774526357 497 TNLSEMKTSSEEINNFVEEIASISEESAAGveqtsasaqqasssMEEVSSNSEELAKLAEELNGLVRQFKI 567
Cdd:COG0840   477 AASEEQSAGTEEVNQAIEQIAAAAQENAAS--------------VEEVAAAAEELAELAEELQELVSRFKL 533
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
17-567 7.52e-81

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 263.03  E-value: 7.52e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357  17 LILSVVLGLFLISTIVVAFFLDDVQSEIEAMERRGDRAVNVTEMGSLIRAKGIRVFQYMEDPTSEVVNEFNQRKDLFKRL 96
Cdd:COG0840    14 LLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357  97 KDDLAEDLSNSEAKTLVEQVVELDEAFNLEFNEVISYVGQGDLEMAAHHADQAHNIQreVVQILEELQELVAADRLIAVN 176
Cdd:COG0840    94 ALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLAL--ALLAAAAAAAAALAALLEAAA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 177 EAKKSQTMAISALIIAIAVSLIISIILIIIVNRIVSRNLNKVVDVSNSIADGNLLVDsIDYHANDEIGQLSRSINKMSTN 256
Cdd:COG0840   172 LALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVR-IDVDSKDEIGQLADAFNRMIEN 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 257 LRKIIQQVSTVSDTVSAQSEELNQSSnevrsgtgqiastmQELASGAETQANHAGDVASKMSDFSQKVHEADENGEKIEG 336
Cdd:COG0840   251 LRELVGQVRESAEQVASASEELAASA--------------EELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAE 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 337 ASTKVLNMAENGSEMMNSSVAQMGRIHTIVQDAVEKVRGLDNQSQEITKLVAVIKDIAEQTNLLALNAAIESARAGEHGK 416
Cdd:COG0840   317 LAEEASELAEEGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGR 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 417 GFAVVADEVRKLAEQVAVSVTDITGIVTNIQSESSNVSQSLEEGYSEVEVGSEQIENTGKTFEQINTAVTDMVSSITTVT 496
Cdd:COG0840   397 GFAVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIA 476

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1774526357 497 TNLSEMKTSSEEINNFVEEIASISEESAAGveqtsasaqqasssMEEVSSNSEELAKLAEELNGLVRQFKI 567
Cdd:COG0840   477 AASEEQSAGTEEVNQAIEQIAAAAQENAAS--------------VEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 291-566 3.33e-63

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 208.29  E-value: 3.33e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357  291 QIASTMQELASGAETQANHAGDVASKMSDFSQKVHEADENGEKIEGASTKVLNMAENGSEMMNSSVAQMGRIHTIVQDAV 370
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357  371 EKVRGLDNQSQEITKLVAVIKDIAEQTNLLALNAAIESARAGEHGKGFAVVADEVRKLAEQVAVSVTDITGIVTNIQSES 450
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEET 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357  451 SNVSQSLEEGYSEVEVGSEQIENTGKTFEQINTAVTDMVSSITTVTTNLSEMKTSSEEINNFVEEIASISEESAAGveqt 530
Cdd:smart00283 161 NEAVAAMEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAM---- 236

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 1774526357  531 sasaqqasssMEEVSSNSEELAKLAEELNGLVRQFK 566
Cdd:smart00283 237 ----------SEEISAAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 319-517 5.65e-51

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 173.58  E-value: 5.65e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 319 DFSQKVHEADENGEKIEGASTKVLNMAENGSEMMNSSVAQMGRIHTIVQDAVEKVRGLDNQSQEITKLVAVIKDIAEQTN 398
Cdd:cd11386     2 ELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQTN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 399 LLALNAAIESARAGEHGKGFAVVADEVRKLAEQVAVSVTDITGIVTNIQSESSNVSQSLEEGYSEVEVGSEQIENTGKTF 478
Cdd:cd11386    82 LLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRAF 161

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1774526357 479 EQINTAVTDMVSSITTVTTNLSEMKTSSEEINNFVEEIA 517
Cdd:cd11386   162 EEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 364-520 6.72e-37

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 134.87  E-value: 6.72e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 364 TIVQDAVEKVRGLDNQSQEITKLVAVIKDIAEQTNLLALNAAIESARAGEHGKGFAVVADEVRKLAEQVAVSVTDITGIV 443
Cdd:pfam00015  16 KEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAERSAQAAKEIEALI 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1774526357 444 TNIQSESSNVSQSLEEGYSEVEVGSEQIENTGKTFEQINTAVTDMVSSITTVTTNLSEMKTSSEEINNFVEEIASIS 520
Cdd:pfam00015  96 IEIQKQTNDSTASIESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVNQAVARMDQVT 172
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
215-525 1.32e-32

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 132.00  E-value: 1.32e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 215 LNKVVDVSNSIADGNLlVDSIDYHANDEIGQLSRSINKMSTNLrkiiqqVSTVSDtvsaqseeLNQSSNEVRSGTGQIAS 294
Cdd:PRK15041  222 MNRLIDSIRHIAGGDL-VKPIEVDGSNEMGQLAESLRHMQGEL------MRTVGD--------VRNGANAIYSGASEIAT 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 295 TMQELASGAETQANHAGDVASKMSDFSQKVHEADENGEKIEgastkvlNMAENGSEmmnssVAQMGriHTIVQDAVEKVR 374
Cdd:PRK15041  287 GNNDLSSRTEQQAASLEETAASMEQLTATVKQNAENARQAS-------HLALSASE-----TAQRG--GKVVDNVVQTMR 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 375 GLDNQSQEITKLVAVIKDIAEQTNLLALNAAIESARAGEHGKGFAVVADEVRKLAEQVAVSVTDITGIVtniqsessnvs 454
Cdd:PRK15041  353 DISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAQAAREIKSLI----------- 421

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1774526357 455 qslEEGYSEVEVGSEQIENTGKTFEQINTA---VTDMVSSITTVTTNLS----EMKTSSEEINNFVEEIASISEESAA 525
Cdd:PRK15041  422 ---EDSVGKVDVGSTLVESAGETMAEIVSAvtrVTDIMGEIASASDEQSrgidQVGLAVAEMDRVTQQNAALVEESAA 496
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
17-567 7.52e-81

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 263.03  E-value: 7.52e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357  17 LILSVVLGLFLISTIVVAFFLDDVQSEIEAMERRGDRAVNVTEMGSLIRAKGIRVFQYMEDPTSEVVNEFNQRKDLFKRL 96
Cdd:COG0840    14 LLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357  97 KDDLAEDLSNSEAKTLVEQVVELDEAFNLEFNEVISYVGQGDLEMAAHHADQAHNIQreVVQILEELQELVAADRLIAVN 176
Cdd:COG0840    94 ALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLAL--ALLAAAAAAAAALAALLEAAA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 177 EAKKSQTMAISALIIAIAVSLIISIILIIIVNRIVSRNLNKVVDVSNSIADGNLLVDsIDYHANDEIGQLSRSINKMSTN 256
Cdd:COG0840   172 LALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVR-IDVDSKDEIGQLADAFNRMIEN 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 257 LRKIIQQVSTVSDTVSAQSEELNQSSnevrsgtgqiastmQELASGAETQANHAGDVASKMSDFSQKVHEADENGEKIEG 336
Cdd:COG0840   251 LRELVGQVRESAEQVASASEELAASA--------------EELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAE 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 337 ASTKVLNMAENGSEMMNSSVAQMGRIHTIVQDAVEKVRGLDNQSQEITKLVAVIKDIAEQTNLLALNAAIESARAGEHGK 416
Cdd:COG0840   317 LAEEASELAEEGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGR 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 417 GFAVVADEVRKLAEQVAVSVTDITGIVTNIQSESSNVSQSLEEGYSEVEVGSEQIENTGKTFEQINTAVTDMVSSITTVT 496
Cdd:COG0840   397 GFAVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIA 476

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1774526357 497 TNLSEMKTSSEEINNFVEEIASISEESAAGveqtsasaqqasssMEEVSSNSEELAKLAEELNGLVRQFKI 567
Cdd:COG0840   477 AASEEQSAGTEEVNQAIEQIAAAAQENAAS--------------VEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 291-566 3.33e-63

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 208.29  E-value: 3.33e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357  291 QIASTMQELASGAETQANHAGDVASKMSDFSQKVHEADENGEKIEGASTKVLNMAENGSEMMNSSVAQMGRIHTIVQDAV 370
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357  371 EKVRGLDNQSQEITKLVAVIKDIAEQTNLLALNAAIESARAGEHGKGFAVVADEVRKLAEQVAVSVTDITGIVTNIQSES 450
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEET 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357  451 SNVSQSLEEGYSEVEVGSEQIENTGKTFEQINTAVTDMVSSITTVTTNLSEMKTSSEEINNFVEEIASISEESAAGveqt 530
Cdd:smart00283 161 NEAVAAMEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAM---- 236

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 1774526357  531 sasaqqasssMEEVSSNSEELAKLAEELNGLVRQFK 566
Cdd:smart00283 237 ----------SEEISAAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 319-517 5.65e-51

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 173.58  E-value: 5.65e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 319 DFSQKVHEADENGEKIEGASTKVLNMAENGSEMMNSSVAQMGRIHTIVQDAVEKVRGLDNQSQEITKLVAVIKDIAEQTN 398
Cdd:cd11386     2 ELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQTN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 399 LLALNAAIESARAGEHGKGFAVVADEVRKLAEQVAVSVTDITGIVTNIQSESSNVSQSLEEGYSEVEVGSEQIENTGKTF 478
Cdd:cd11386    82 LLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRAF 161

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1774526357 479 EQINTAVTDMVSSITTVTTNLSEMKTSSEEINNFVEEIA 517
Cdd:cd11386   162 EEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 364-520 6.72e-37

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 134.87  E-value: 6.72e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 364 TIVQDAVEKVRGLDNQSQEITKLVAVIKDIAEQTNLLALNAAIESARAGEHGKGFAVVADEVRKLAEQVAVSVTDITGIV 443
Cdd:pfam00015  16 KEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAERSAQAAKEIEALI 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1774526357 444 TNIQSESSNVSQSLEEGYSEVEVGSEQIENTGKTFEQINTAVTDMVSSITTVTTNLSEMKTSSEEINNFVEEIASIS 520
Cdd:pfam00015  96 IEIQKQTNDSTASIESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVNQAVARMDQVT 172
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
215-525 1.32e-32

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 132.00  E-value: 1.32e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 215 LNKVVDVSNSIADGNLlVDSIDYHANDEIGQLSRSINKMSTNLrkiiqqVSTVSDtvsaqseeLNQSSNEVRSGTGQIAS 294
Cdd:PRK15041  222 MNRLIDSIRHIAGGDL-VKPIEVDGSNEMGQLAESLRHMQGEL------MRTVGD--------VRNGANAIYSGASEIAT 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 295 TMQELASGAETQANHAGDVASKMSDFSQKVHEADENGEKIEgastkvlNMAENGSEmmnssVAQMGriHTIVQDAVEKVR 374
Cdd:PRK15041  287 GNNDLSSRTEQQAASLEETAASMEQLTATVKQNAENARQAS-------HLALSASE-----TAQRG--GKVVDNVVQTMR 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 375 GLDNQSQEITKLVAVIKDIAEQTNLLALNAAIESARAGEHGKGFAVVADEVRKLAEQVAVSVTDITGIVtniqsessnvs 454
Cdd:PRK15041  353 DISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAQAAREIKSLI----------- 421

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1774526357 455 qslEEGYSEVEVGSEQIENTGKTFEQINTA---VTDMVSSITTVTTNLS----EMKTSSEEINNFVEEIASISEESAA 525
Cdd:PRK15041  422 ---EDSVGKVDVGSTLVESAGETMAEIVSAvtrVTDIMGEIASASDEQSrgidQVGLAVAEMDRVTQQNAALVEESAA 496
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
223-567 2.09e-32

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 130.96  E-value: 2.09e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 223 NSIADGNLlVDSIDYHANDEIGQLSRSINKMSTNLRKiiqqvsTVSDtvsaqseeLNQSSNEVRSGTGQIASTMQELASG 302
Cdd:PRK09793  226 DSIAAGNL-ARPIAVYGRNEITAIFASLKTMQQALRG------TVSD--------VRKGSQEMHIGIAEIVAGNNDLSSR 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 303 AETQANHAGDVASKMSDFSQKVHEADENGEKIEGASTKVLNMAENGSEmmnssvaQMGRIHTIVQDavekvrgLDNQSQE 382
Cdd:PRK09793  291 TEQQAASLAQTAASMEQLTATVGQNADNARQASELAKNAATTAQAGGV-------QVSTMTHTMQE-------IATSSQK 356

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 383 ITKLVAVIKDIAEQTNLLALNAAIESARAGEHGKGFAVVADEVRKLAEQVAVSVTDITGIVtniqsessnvsqslEEGYS 462
Cdd:PRK09793  357 IGDIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKGLI--------------EESVN 422

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 463 EVEVGSEQIENTGKTfeqintaVTDMVSSITTVTTNLSEMKTSSEEINNFVEEIASiseesaaGVEQTSASAQQASSSME 542
Cdd:PRK09793  423 RVQQGSKLVNNAAAT-------MTDIVSSVTRVNDIMGEIASASEEQRRGIEQVAQ-------AVSQMDQVTQQNASLVE 488

                         330       340
                  ....*....|....*....|....*
gi 1774526357 543 EVSSNSEELAKLAEELNGLVRQFKI 567
Cdd:PRK09793  489 EAAVATEQLANQADHLSSRVAVFTL 513
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 207-521 2.97e-28

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 118.96  E-value: 2.97e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 207 VNRIVSRNLNKVVDVSNSIADGNLlVDSIDYHANDEIGQLSRSINKMSTNLRKIIQQVstvsdtvsaqseelNQSSNEVR 286
Cdd:PRK15048  212 IRRMLLTPLAKIIAHIREIAGGNL-ANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHV--------------REGSDAIY 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 287 SGTGQIASTMQELASGAETQANHAGDVASKMSDFSQKVHEADENGEKiegAStkvlNMAENGSEmmnssVAQMGriHTIV 366
Cdd:PRK15048  277 AGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADNARQ---AS----QLAQSASD-----TAQHG--GKVV 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 367 QDAVEKVRGLDNQSQEITKLVAVIKDIAEQTNLLALNAAIESARAGEHGKGFAVVADEVRKLAEQVAVSVTDITGIVtni 446
Cdd:PRK15048  343 DGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKALI--- 419

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1774526357 447 qsessnvsqslEEGYSEVEVGSEQIENTGKTfeqintaVTDMVSSITTVTTNLSEMKTSSEEINNFVEEIA-SISE 521
Cdd:PRK15048  420 -----------EDSVSRVDTGSVLVESAGET-------MNNIVNAVTRVTDIMGEIASASDEQSRGIDQVAlAVSE 477
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 212-257 3.82e-07

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 46.67  E-value: 3.82e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1774526357 212 SRNLNKVVDVSNSIADGNLLVdSIDYHANDEIGQLSRSINKMSTNL 257
Cdd:cd06225     1 TRPLRRLTEAARRIAEGDLDV-RVPVRSKDEIGELARAFNQMAERL 45
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
209-262 4.52e-07

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 46.86  E-value: 4.52e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1774526357  209 RIVSRNLNKVVDVSNSIADGNLLVDsIDYHANDEIGQLSRSINKMSTNLRKIIQ 262
Cdd:smart00304   1 RRLLRPLRRLAEAAQRIADGDLTVR-LPVDGRDEIGELARAFNEMADRLEETIA 53
HAMP pfam00672
HAMP domain;
207-259 1.08e-06

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 45.69  E-value: 1.08e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1774526357 207 VNRIVSRNLNKVVDVSNSIADGNLLVDsIDYHANDEIGQLSRSINKMSTNLRK 259
Cdd:pfam00672   2 LARRILRPLRRLAEAARRIASGDLDVR-LPVSGRDEIGELARAFNQMAERLRE 53
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 209-264 1.91e-04

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 44.18  E-value: 1.91e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1774526357 209 RIVSRNLNKVVDVSNSIADGNLLVdSIDYHANDEIGQLSRSINKMSTNLRKIIQQV 264
Cdd:COG5000    31 RRLTRPLRRLAEATRAVAAGDLSV-RLPVTGDDEIGELARAFNRMTDQLKEQREEL 85
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
3-561 1.88e-03

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 41.25  E-value: 1.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357   3 RLRFKNVKIGTKYGLILSVVLGLFLISTIVVAFFLDDVQSEIEAMERRGDRAVNVTEMGSLIRAKGIRVFQYMEDPTSEV 82
Cdd:COG2770    29 ALISLRLLLALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357  83 VNEFNQRKDLFKRLKDDLAEDLSNSEAKTLVEQVVELDEAfNLEFNEVISYVGQGDLEMAAHHADQAHNIQREVVQILEE 162
Cdd:COG2770   109 LLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLA-AARLLLAALLALAAALALALGAGELLLLADLAAAIAALL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 163 LQELVAADRLIAVNEAKKSQTMAISALIIAIAVSLIISIILIIIVNRIVSRNLNKVVDVSNSIADGNLLVDsIDYHANDE 242
Cdd:COG2770   188 AALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVR-IPVSRKDE 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 243 IGQLSRSINKMSTNLRKIIQQVSTVSDTVSAQSEELNQSSNEVRSGTGQIASTMQELASGAETQANHAGDVASKMSDFSQ 322
Cdd:COG2770   267 IGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLL 346

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 323 KVHEADENGEKIEGASTKVLNMAENGSEMMNSSVAQMGRIHTIVQDAVEKVRGLDNQSQEITKLVAVIKDIAEQTNLLAL 402
Cdd:COG2770   347 AADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAA 426

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774526357 403 NAAIESARAGEHGKGFAVVADEVRKLAEQVAVSVTDITGIVTNIQSESSNVSQSLEEGYSEVEVGSEQIENTGKTFEQIN 482
Cdd:COG2770   427 AAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELA 506

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1774526357 483 TAVTDMVSSITTVTTNLSEMKTSSEEINNFVEEIASISEESAAGVEQTSASAQQASSSMEEVSSNSEELAKLAEELNGL 561
Cdd:COG2770   507 EELLLLEGLLLLLLLEAEALEVAEELLELEEAALLLAAAAELAALLALLLALAAVEAAALLLAALLLAAVAALLELAAL 585
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
207-264 8.94e-03

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 38.85  E-value: 8.94e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1774526357 207 VNRIVSRNLNKVVDVSNSIADGNLLvdSIDYHANDEIGQLSRSINKMSTNLRKIIQQV 264
Cdd:COG2972   177 LSRSITRPIKRLKKAMKKVEKGDLV--RLEVSGNDEIGILARSFNEMVERIKELIEEV 232
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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