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Conserved domains on  [gi|1770136113|gb|QFT74951|]
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Trimethylamine methyltransferase (MTTB) (plasmid) [Ruegeria sp. THAF33]

Protein Classification

trimethylamine methyltransferase family protein( domain architecture ID 10009465)

trimethylamine methyltransferase family protein similar to Desulfitobacterium hafniense glycine betaine methyltransferase that likely methylates a corrinoid protein, likely the adjacently encoded DSY3155, with glycine betaine, to then supply methyl groups to tetrahydrofolate for ultimate conversion to carbon dioxide

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MttB2 COG5598
Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];
34-504 0e+00

Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];


:

Pssm-ID: 444334  Cd Length: 469  Bit Score: 525.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113  34 RFKPLSPKEVALVEDAALTLLETLGLSQAIPSMIERVSKAGGRLtDDGRLLFPRGLVQEAISKAQRGFTLCGQSPMHDLC 113
Cdd:COG5598     2 RYEPLSEEQIERIHEAALRILEEIGVEFEHEEALEIFKKAGARV-EGGRVRIPRALVEEALATAPSSFTLYARNPERDVE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 114 IEGARVHMSTGGAAPGVFDLDTGAYRDSTLADLYDAARIVDQMDNIHHFSRS-VVARDIDDNaEMDINTAYACLMGTSKH 192
Cdd:COG5598    81 LGGGNVVFGPGGGAPFVLDLETGERRPATLEDLANFAKLADALPNIDFSGGNpVEPSDVPVE-VRHLDMLYAMLKYTDKP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 193 VSISISEPENVPAIAELCYRIAGGEATFRARPFLTVMVChVVPPMRFAEEACAVLEAAINAGFPVQLISAGQAGATSPAT 272
Cdd:COG5598   160 IMGSATGRERVEDSIEMARIVAGGEEELREKPVVITLIN-PNSPLRFDEEMLEALIAYARAGQPVIITPFGLAGATAPVT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 273 IAGSLVQAVAETLAGLVFARLVDPEVKAIFAPKPLVADLRTGSMSGGGGEQAILMAGAAQMGRHFDLPTSSIAGITDAKC 352
Cdd:COG5598   239 LAGALAQQNAEALAGLVLAQLIRPGAPVIYGTFSSSMDMRTGAPAFGTPEAALLSAAAAQLARYYGLPSRSGGGLTDSKL 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 353 LDAQYGAEKSLAVAMAAHAGSNIVTQAAGMMSSLLGVSHAAYVSDNDLLGNILRTLRGIEATPENIAAEVIAGVCHGeGH 432
Cdd:COG5598   319 PDAQAGYESAMSLLAAALAGANLILHAAGWLESGLTASYEKFVLDNEIIGMVRRLLRGIEVDEETLALDAIKEVGPG-GH 397

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1770136113 433 YLGETHTFDRMKSDYFYPGVGDRRTPREWQQDGAHPVGDLARQSAQDILATHYPRHIPDDLDRALRARFDIR 504
Cdd:COG5598   398 FLGHPHTLKHYRTEFYYPKLSDRENYEQWEEAGSKDLLERANEKVKEILAEYEPPPLDPEIDEELDAYIARR 469
 
Name Accession Description Interval E-value
MttB2 COG5598
Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];
34-504 0e+00

Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];


Pssm-ID: 444334  Cd Length: 469  Bit Score: 525.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113  34 RFKPLSPKEVALVEDAALTLLETLGLSQAIPSMIERVSKAGGRLtDDGRLLFPRGLVQEAISKAQRGFTLCGQSPMHDLC 113
Cdd:COG5598     2 RYEPLSEEQIERIHEAALRILEEIGVEFEHEEALEIFKKAGARV-EGGRVRIPRALVEEALATAPSSFTLYARNPERDVE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 114 IEGARVHMSTGGAAPGVFDLDTGAYRDSTLADLYDAARIVDQMDNIHHFSRS-VVARDIDDNaEMDINTAYACLMGTSKH 192
Cdd:COG5598    81 LGGGNVVFGPGGGAPFVLDLETGERRPATLEDLANFAKLADALPNIDFSGGNpVEPSDVPVE-VRHLDMLYAMLKYTDKP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 193 VSISISEPENVPAIAELCYRIAGGEATFRARPFLTVMVChVVPPMRFAEEACAVLEAAINAGFPVQLISAGQAGATSPAT 272
Cdd:COG5598   160 IMGSATGRERVEDSIEMARIVAGGEEELREKPVVITLIN-PNSPLRFDEEMLEALIAYARAGQPVIITPFGLAGATAPVT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 273 IAGSLVQAVAETLAGLVFARLVDPEVKAIFAPKPLVADLRTGSMSGGGGEQAILMAGAAQMGRHFDLPTSSIAGITDAKC 352
Cdd:COG5598   239 LAGALAQQNAEALAGLVLAQLIRPGAPVIYGTFSSSMDMRTGAPAFGTPEAALLSAAAAQLARYYGLPSRSGGGLTDSKL 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 353 LDAQYGAEKSLAVAMAAHAGSNIVTQAAGMMSSLLGVSHAAYVSDNDLLGNILRTLRGIEATPENIAAEVIAGVCHGeGH 432
Cdd:COG5598   319 PDAQAGYESAMSLLAAALAGANLILHAAGWLESGLTASYEKFVLDNEIIGMVRRLLRGIEVDEETLALDAIKEVGPG-GH 397

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1770136113 433 YLGETHTFDRMKSDYFYPGVGDRRTPREWQQDGAHPVGDLARQSAQDILATHYPRHIPDDLDRALRARFDIR 504
Cdd:COG5598   398 FLGHPHTLKHYRTEFYYPKLSDRENYEQWEEAGSKDLLERANEKVKEILAEYEPPPLDPEIDEELDAYIARR 469
MTTB pfam06253
Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine ...
 6-508 1.01e-171

Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.


Pssm-ID: 428852  Cd Length: 502  Bit Score: 493.71  E-value: 1.01e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113   6 RRRGRKERLKQTDEPDPnPPVWPGLEG--ARFKPLSPKEVALVEDAALTLLETLGLSQAIPSMIERVSKAGGRLtDDGRL 83
Cdd:pfam06253   1 RRGGRAARRARRAAPRA-DQSWPYIVRgiPPYEPLSEEGIAAIEEAAMRILEEIGIEFRDPEALELWRAAGADV-DGERV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113  84 LFPRGLVQEAISKAQRGFTLCGQSPMHDLCIEGARVHMSTGGAAPGVFDLDTGaYRDSTLADLYDAARIVDQMDNIHHFS 163
Cdd:pfam06253  79 RFDRGLVRELLATAPRQFTLHARNPERDVVIGGNNLVFAPVYGPPFVRDLDRG-RRYGTLADFRNFVKLTQMFPWLHHSG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 164 RSVV-ARDIDDNAEmDINTAYACLMGTSKHVSISISEPENVPAIAELCYRIAGGE-ATFRARPFLTVMVcHVVPPMRFAE 241
Cdd:pfam06253 158 GTVVePVDVPVNKR-HLDMLYAHLTLSDKPFMGSVTGPERAEDSIEMCRILFGLSfAEFRANPVMTTNI-NVNSPLTFDE 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 242 EACAVLEAAINAGFPVQLISAGQAGATSPATIAGSLVQAVAETLAGLVFARLVDPEVKAIFAPKPLVADLRTGSMSGGGG 321
Cdd:pfam06253 236 TMLGGLRVYARAGQAVIVTPFILAGAMAPVTVAGALAQSLAEALAGIALTQLVRPGAPVIYGTFTSNVDMKSGAPTFGTP 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 322 EQAILMAGAAQMGRHFDLPTSSIAGITDAKCLDAQYGAEKSLAVAMAAHAGSNIVTQAAGMMSSLLGVSHAAYVSDNDLL 401
Cdd:pfam06253 316 EPALATYVAGQLARRYGLPWRSSGGLTASKIPDAQAAYESAMSLWAALLAGANFVLHAAGWLEGGLTASYEKFVMDADML 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 402 GNILRTLRGIEATPENIAAEVIAGVCHGeGHYLGETHTFDRMKSDYFYPGVGDRRTPREWQQDGAHPVGDLARQSAQDIL 481
Cdd:pfam06253 396 GMIHRLLAGIDVSDDALAMDAIREVGPG-GHFLGCAHTQARYETAFYRPELSDWRNFETWEEEGAKDTAERANRRWKKIL 474

                         490       500
                  ....*....|....*....|....*..
gi 1770136113 482 ATHYPRHIPDDLDRALRArFDIRLTRE 508
Cdd:pfam06253 475 AEYEAPPLDPAIDEALRD-FIARRKAE 500
 
Name Accession Description Interval E-value
MttB2 COG5598
Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];
34-504 0e+00

Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];


Pssm-ID: 444334  Cd Length: 469  Bit Score: 525.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113  34 RFKPLSPKEVALVEDAALTLLETLGLSQAIPSMIERVSKAGGRLtDDGRLLFPRGLVQEAISKAQRGFTLCGQSPMHDLC 113
Cdd:COG5598     2 RYEPLSEEQIERIHEAALRILEEIGVEFEHEEALEIFKKAGARV-EGGRVRIPRALVEEALATAPSSFTLYARNPERDVE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 114 IEGARVHMSTGGAAPGVFDLDTGAYRDSTLADLYDAARIVDQMDNIHHFSRS-VVARDIDDNaEMDINTAYACLMGTSKH 192
Cdd:COG5598    81 LGGGNVVFGPGGGAPFVLDLETGERRPATLEDLANFAKLADALPNIDFSGGNpVEPSDVPVE-VRHLDMLYAMLKYTDKP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 193 VSISISEPENVPAIAELCYRIAGGEATFRARPFLTVMVChVVPPMRFAEEACAVLEAAINAGFPVQLISAGQAGATSPAT 272
Cdd:COG5598   160 IMGSATGRERVEDSIEMARIVAGGEEELREKPVVITLIN-PNSPLRFDEEMLEALIAYARAGQPVIITPFGLAGATAPVT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 273 IAGSLVQAVAETLAGLVFARLVDPEVKAIFAPKPLVADLRTGSMSGGGGEQAILMAGAAQMGRHFDLPTSSIAGITDAKC 352
Cdd:COG5598   239 LAGALAQQNAEALAGLVLAQLIRPGAPVIYGTFSSSMDMRTGAPAFGTPEAALLSAAAAQLARYYGLPSRSGGGLTDSKL 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 353 LDAQYGAEKSLAVAMAAHAGSNIVTQAAGMMSSLLGVSHAAYVSDNDLLGNILRTLRGIEATPENIAAEVIAGVCHGeGH 432
Cdd:COG5598   319 PDAQAGYESAMSLLAAALAGANLILHAAGWLESGLTASYEKFVLDNEIIGMVRRLLRGIEVDEETLALDAIKEVGPG-GH 397

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1770136113 433 YLGETHTFDRMKSDYFYPGVGDRRTPREWQQDGAHPVGDLARQSAQDILATHYPRHIPDDLDRALRARFDIR 504
Cdd:COG5598   398 FLGHPHTLKHYRTEFYYPKLSDRENYEQWEEAGSKDLLERANEKVKEILAEYEPPPLDPEIDEELDAYIARR 469
MTTB pfam06253
Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine ...
 6-508 1.01e-171

Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.


Pssm-ID: 428852  Cd Length: 502  Bit Score: 493.71  E-value: 1.01e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113   6 RRRGRKERLKQTDEPDPnPPVWPGLEG--ARFKPLSPKEVALVEDAALTLLETLGLSQAIPSMIERVSKAGGRLtDDGRL 83
Cdd:pfam06253   1 RRGGRAARRARRAAPRA-DQSWPYIVRgiPPYEPLSEEGIAAIEEAAMRILEEIGIEFRDPEALELWRAAGADV-DGERV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113  84 LFPRGLVQEAISKAQRGFTLCGQSPMHDLCIEGARVHMSTGGAAPGVFDLDTGaYRDSTLADLYDAARIVDQMDNIHHFS 163
Cdd:pfam06253  79 RFDRGLVRELLATAPRQFTLHARNPERDVVIGGNNLVFAPVYGPPFVRDLDRG-RRYGTLADFRNFVKLTQMFPWLHHSG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 164 RSVV-ARDIDDNAEmDINTAYACLMGTSKHVSISISEPENVPAIAELCYRIAGGE-ATFRARPFLTVMVcHVVPPMRFAE 241
Cdd:pfam06253 158 GTVVePVDVPVNKR-HLDMLYAHLTLSDKPFMGSVTGPERAEDSIEMCRILFGLSfAEFRANPVMTTNI-NVNSPLTFDE 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 242 EACAVLEAAINAGFPVQLISAGQAGATSPATIAGSLVQAVAETLAGLVFARLVDPEVKAIFAPKPLVADLRTGSMSGGGG 321
Cdd:pfam06253 236 TMLGGLRVYARAGQAVIVTPFILAGAMAPVTVAGALAQSLAEALAGIALTQLVRPGAPVIYGTFTSNVDMKSGAPTFGTP 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 322 EQAILMAGAAQMGRHFDLPTSSIAGITDAKCLDAQYGAEKSLAVAMAAHAGSNIVTQAAGMMSSLLGVSHAAYVSDNDLL 401
Cdd:pfam06253 316 EPALATYVAGQLARRYGLPWRSSGGLTASKIPDAQAAYESAMSLWAALLAGANFVLHAAGWLEGGLTASYEKFVMDADML 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1770136113 402 GNILRTLRGIEATPENIAAEVIAGVCHGeGHYLGETHTFDRMKSDYFYPGVGDRRTPREWQQDGAHPVGDLARQSAQDIL 481
Cdd:pfam06253 396 GMIHRLLAGIDVSDDALAMDAIREVGPG-GHFLGCAHTQARYETAFYRPELSDWRNFETWEEEGAKDTAERANRRWKKIL 474

                         490       500
                  ....*....|....*....|....*..
gi 1770136113 482 ATHYPRHIPDDLDRALRArFDIRLTRE 508
Cdd:pfam06253 475 AEYEAPPLDPAIDEALRD-FIARRKAE 500
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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