NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1757088778|gb|QFG47950|]
View 

PTS sugar transporter subunit IIA [Lacticaseibacillus rhamnosus]

Protein Classification

PTS sugar transporter subunit IIA( domain architecture ID 10006772)

PTS mannose/fructose/sorbose family sugar transporter subunit IIA is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), which catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane

CATH:  3.40.50.510
Gene Ontology:  GO:0009401|GO:0016310|GO:0016301|GO:0008643|GO:1902495
PubMed:  11532441|10393270
SCOP:  4000512

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ManX COG2893
Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and ...
 4-122 9.66e-41

Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism];


:

Pssm-ID: 442138 [Multi-domain]  Cd Length: 126  Bit Score: 131.80  E-value: 9.66e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757088778   4 LVLISHGQLCEELKKSAEMIMGPQDDIATVALLPNEGPEDFQAKFKAAIEG---EDDVTVLADLKGGTPNNVAARVLAEG 80
Cdd:COG2893     1 IVIATHGPLAEGLLSSAEMILGEQENVEAVDLYPGDDPEDLREKLEEAIAEldsGDGVLILTDLFGGTPSNVAARLLAKH 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1757088778  81 GKFDLYAGMNLPMVISFLNAQML----DMKPDLLGDGKAGVVYIND 122
Cdd:COG2893    81 ENVEVIAGVNLPMLLEALTYREDlsldELVEKALEAGREGIKSLSE 126
 
Name Accession Description Interval E-value
ManX COG2893
Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and ...
 4-122 9.66e-41

Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 442138 [Multi-domain]  Cd Length: 126  Bit Score: 131.80  E-value: 9.66e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757088778   4 LVLISHGQLCEELKKSAEMIMGPQDDIATVALLPNEGPEDFQAKFKAAIEG---EDDVTVLADLKGGTPNNVAARVLAEG 80
Cdd:COG2893     1 IVIATHGPLAEGLLSSAEMILGEQENVEAVDLYPGDDPEDLREKLEEAIAEldsGDGVLILTDLFGGTPSNVAARLLAKH 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1757088778  81 GKFDLYAGMNLPMVISFLNAQML----DMKPDLLGDGKAGVVYIND 122
Cdd:COG2893    81 ENVEVIAGVNLPMLLEALTYREDlsldELVEKALEAGREGIKSLSE 126
PTS_IIA_man cd00006
PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 3-108 1.02e-32

PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. IIA subunits receive phosphoryl groups from HPr and transfer them to IIB subunits, which in turn phosphorylate the substrate.


Pssm-ID: 237978 [Multi-domain]  Cd Length: 122  Bit Score: 111.16  E-value: 1.02e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757088778   3 KLVLISHGQLCEELKKSAEMIMGPQDDIATVALLPNEGPEDFQAKFKAAIEG---EDDVTVLADLKGGTPNNVAARVLAE 79
Cdd:cd00006     2 GIIIATHGGFASGLLNSAEMILGEQENVEAIDFPPGESPDDLLEKIKAALAEldsGEGVLILTDLFGGSPNNAAARLSME 81

                          90       100
                  ....*....|....*....|....*....
gi 1757088778  80 GGKFDLYAGMNLPMVISFLNAQMLDMKPD 108
Cdd:cd00006    82 HPPVEVIAGVNLPMLLEAARARELGLSLD 110
EIIA-man pfam03610
PTS system fructose IIA component;
3-109 6.56e-24

PTS system fructose IIA component;


Pssm-ID: 427399 [Multi-domain]  Cd Length: 113  Bit Score: 88.46  E-value: 6.56e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757088778   3 KLVLISHGQLCEELKKSAEMIMGPQDDIATVALLPNEGPEDFQAKFKAAIE---GEDDVTVLADLKGGTPNNVAARVLAE 79
Cdd:pfam03610   1 GIVIVSHGELAEGLLELAEMMAGEQENVIAVGGTPGESIGTSFEKIVEAIEnldSGDGVLVLVDLGGATPNNEAALELLE 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1757088778  80 GGKFDLYAGMNLPMVI-SFLNAQMLDMKPDL 109
Cdd:pfam03610  81 KERMEVITGVNLPMVEgAYAARVSASLGELV 111
EIIA-man TIGR00824
PTS system, mannose/fructose/sorbose family, IIA component; Bacterial PTS transporters ...
 1-101 2.99e-20

PTS system, mannose/fructose/sorbose family, IIA component; Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Man family is unique in several respects among PTS permease families It is the only PTS family in which members possess a IID protein. It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue. Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars. The mannose permease of E. coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine, N-acetylglucosamine, and other sugars. Other members of this can transport sorbose, fructose and N-acetylglucosamine. This family is specific for the IIA components. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 129904  Cd Length: 116  Bit Score: 79.43  E-value: 2.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757088778   1 MSKLVLISHGQLCEELKKSAEMIMGPQDDIATVALLPNEGPEDFQAKFKAA---IEGEDDVTVLADLKGGTPNNVAARVL 77
Cdd:TIGR00824   1 MIAIIISGHGQAAIALLKSAEMIFGEQNNVGAVPFVPGENAETLQEKYNAAladLDTEEEVLFLVDIFGGSPYNAAARII 80

                          90       100
                  ....*....|....*....|....
gi 1757088778  78 AEGGKFDLYAGMNLPMVISFLNAQ 101
Cdd:TIGR00824  81 VDKPHMDVIAGVNLPLLLETLMAR 104
PRK15088 PRK15088
PTS system mannose-specific transporter subunits IIAB; Provisional
 4-96 1.71e-15

PTS system mannose-specific transporter subunits IIAB; Provisional


Pssm-ID: 185045 [Multi-domain]  Cd Length: 322  Bit Score: 70.79  E-value: 1.71e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757088778   4 LVLISHGQLCEELKKSAEMIMGPQDDIATVALLPNEGPEDFQAKFKAAIEG---EDDVTVLADLKGGTPNNVAARVLAEG 80
Cdd:PRK15088    5 IIIGTHGWAAEQLLKTAEMLLGEQENVAWIDFVPGENAETLIEKYNAQLAKldtSKGVLFLVDTWGGSPFNAASRIVVDK 84

                          90
                  ....*....|....*.
gi 1757088778  81 GKFDLYAGMNLPMVIS 96
Cdd:PRK15088   85 ENYEVITGVNIPMLVE 100
 
Name Accession Description Interval E-value
ManX COG2893
Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and ...
 4-122 9.66e-41

Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 442138 [Multi-domain]  Cd Length: 126  Bit Score: 131.80  E-value: 9.66e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757088778   4 LVLISHGQLCEELKKSAEMIMGPQDDIATVALLPNEGPEDFQAKFKAAIEG---EDDVTVLADLKGGTPNNVAARVLAEG 80
Cdd:COG2893     1 IVIATHGPLAEGLLSSAEMILGEQENVEAVDLYPGDDPEDLREKLEEAIAEldsGDGVLILTDLFGGTPSNVAARLLAKH 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1757088778  81 GKFDLYAGMNLPMVISFLNAQML----DMKPDLLGDGKAGVVYIND 122
Cdd:COG2893    81 ENVEVIAGVNLPMLLEALTYREDlsldELVEKALEAGREGIKSLSE 126
PTS_IIA_man cd00006
PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 3-108 1.02e-32

PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. IIA subunits receive phosphoryl groups from HPr and transfer them to IIB subunits, which in turn phosphorylate the substrate.


Pssm-ID: 237978 [Multi-domain]  Cd Length: 122  Bit Score: 111.16  E-value: 1.02e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757088778   3 KLVLISHGQLCEELKKSAEMIMGPQDDIATVALLPNEGPEDFQAKFKAAIEG---EDDVTVLADLKGGTPNNVAARVLAE 79
Cdd:cd00006     2 GIIIATHGGFASGLLNSAEMILGEQENVEAIDFPPGESPDDLLEKIKAALAEldsGEGVLILTDLFGGSPNNAAARLSME 81

                          90       100
                  ....*....|....*....|....*....
gi 1757088778  80 GGKFDLYAGMNLPMVISFLNAQMLDMKPD 108
Cdd:cd00006    82 HPPVEVIAGVNLPMLLEAARARELGLSLD 110
EIIA-man pfam03610
PTS system fructose IIA component;
3-109 6.56e-24

PTS system fructose IIA component;


Pssm-ID: 427399 [Multi-domain]  Cd Length: 113  Bit Score: 88.46  E-value: 6.56e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757088778   3 KLVLISHGQLCEELKKSAEMIMGPQDDIATVALLPNEGPEDFQAKFKAAIE---GEDDVTVLADLKGGTPNNVAARVLAE 79
Cdd:pfam03610   1 GIVIVSHGELAEGLLELAEMMAGEQENVIAVGGTPGESIGTSFEKIVEAIEnldSGDGVLVLVDLGGATPNNEAALELLE 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1757088778  80 GGKFDLYAGMNLPMVI-SFLNAQMLDMKPDL 109
Cdd:pfam03610  81 KERMEVITGVNLPMVEgAYAARVSASLGELV 111
EIIA-man TIGR00824
PTS system, mannose/fructose/sorbose family, IIA component; Bacterial PTS transporters ...
 1-101 2.99e-20

PTS system, mannose/fructose/sorbose family, IIA component; Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Man family is unique in several respects among PTS permease families It is the only PTS family in which members possess a IID protein. It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue. Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars. The mannose permease of E. coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine, N-acetylglucosamine, and other sugars. Other members of this can transport sorbose, fructose and N-acetylglucosamine. This family is specific for the IIA components. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 129904  Cd Length: 116  Bit Score: 79.43  E-value: 2.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757088778   1 MSKLVLISHGQLCEELKKSAEMIMGPQDDIATVALLPNEGPEDFQAKFKAA---IEGEDDVTVLADLKGGTPNNVAARVL 77
Cdd:TIGR00824   1 MIAIIISGHGQAAIALLKSAEMIFGEQNNVGAVPFVPGENAETLQEKYNAAladLDTEEEVLFLVDIFGGSPYNAAARII 80

                          90       100
                  ....*....|....*....|....
gi 1757088778  78 AEGGKFDLYAGMNLPMVISFLNAQ 101
Cdd:TIGR00824  81 VDKPHMDVIAGVNLPLLLETLMAR 104
PRK15088 PRK15088
PTS system mannose-specific transporter subunits IIAB; Provisional
 4-96 1.71e-15

PTS system mannose-specific transporter subunits IIAB; Provisional


Pssm-ID: 185045 [Multi-domain]  Cd Length: 322  Bit Score: 70.79  E-value: 1.71e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1757088778   4 LVLISHGQLCEELKKSAEMIMGPQDDIATVALLPNEGPEDFQAKFKAAIEG---EDDVTVLADLKGGTPNNVAARVLAEG 80
Cdd:PRK15088    5 IIIGTHGWAAEQLLKTAEMLLGEQENVAWIDFVPGENAETLIEKYNAQLAKldtSKGVLFLVDTWGGSPFNAASRIVVDK 84

                          90
                  ....*....|....*.
gi 1757088778  81 GKFDLYAGMNLPMVIS 96
Cdd:PRK15088   85 ENYEVITGVNIPMLVE 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH