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Conserved domains on  [gi|1752924942|gb|QEW97236|]
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nucleotide sugar dehydrogenase [Enterococcus faecium]

Protein Classification

UDP-glucose 6-dehydrogenase family protein( domain architecture ID 1001292)

UDP-glucose 6-dehydrogenase is involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate; may be partial

CATH:  1.20.5.100|3.40.50.720
EC:  1.1.1.22
Gene Ontology:  GO:0051287|GO:0003979|GO:0006065|GO:0045227
PubMed:  10841783|31189734

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15057 super family cl33071
UDP-glucose 6-dehydrogenase; Provisional
 7-416 0e+00

UDP-glucose 6-dehydrogenase; Provisional


The actual alignment was detected with superfamily member PRK15057:

Pssm-ID: 185017 [Multi-domain]  Cd Length: 388  Bit Score: 553.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   7 IAVAGTGYVGLSIATLLAQHHQVTAVDIIPEKIELINKRKSPIQDEYIEKYLTEKELDLTATLDARSAYKSADFVVIATP 86
Cdd:PRK15057    3 ITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIATP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942  87 TNYDSRTQHFDTSAVESVIEVVMDVNPDTIMVIKSTIPVGYTESVRETTGSKNIIFSPEFLRESKALYDNLYPSRIIVGT 166
Cdd:PRK15057   83 TDYDPKTNYFNTSSVESVIKDVVEINPYAVMVIKSTVPVGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVIGE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 167 DmtDERllnaAHVFATLLQKSAIKENVDTLFMGFTEAEAVKLFANTYLALRVSYFNELDTYAEMKGLNTQQIINGVCLDP 246
Cdd:PRK15057  163 R--SER----AERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNTRQIIEGVCLDP 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 247 RIGTHYNNPSFGYGGYCLPKDTKQLLANYADVPGNLIEAIVESNRTRKDFIADRVLQmagyynyaeynqydvnrENPVLI 326
Cdd:PRK15057  237 RIGNHYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILS-----------------RKPQVV 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 327 GIYRLTMKSNSDNFRQSSIQGVMKRVKAKGATVVIYEPALKDgETFFGSKVINDLEQFKAMCDSIIANRYDTCLDDIKEK 406
Cdd:PRK15057  300 GIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPVMKE-DSFFNSRLERDLATFKQQADVIISNRMAEELKDVADK 378

                         410
                  ....*....|
gi 1752924942 407 VYTRDIFQRD 416
Cdd:PRK15057  379 VYTRDLFGSD 388
 
Name Accession Description Interval E-value
PRK15057 PRK15057
UDP-glucose 6-dehydrogenase; Provisional
 7-416 0e+00

UDP-glucose 6-dehydrogenase; Provisional


Pssm-ID: 185017 [Multi-domain]  Cd Length: 388  Bit Score: 553.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   7 IAVAGTGYVGLSIATLLAQHHQVTAVDIIPEKIELINKRKSPIQDEYIEKYLTEKELDLTATLDARSAYKSADFVVIATP 86
Cdd:PRK15057    3 ITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIATP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942  87 TNYDSRTQHFDTSAVESVIEVVMDVNPDTIMVIKSTIPVGYTESVRETTGSKNIIFSPEFLRESKALYDNLYPSRIIVGT 166
Cdd:PRK15057   83 TDYDPKTNYFNTSSVESVIKDVVEINPYAVMVIKSTVPVGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVIGE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 167 DmtDERllnaAHVFATLLQKSAIKENVDTLFMGFTEAEAVKLFANTYLALRVSYFNELDTYAEMKGLNTQQIINGVCLDP 246
Cdd:PRK15057  163 R--SER----AERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNTRQIIEGVCLDP 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 247 RIGTHYNNPSFGYGGYCLPKDTKQLLANYADVPGNLIEAIVESNRTRKDFIADRVLQmagyynyaeynqydvnrENPVLI 326
Cdd:PRK15057  237 RIGNHYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILS-----------------RKPQVV 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 327 GIYRLTMKSNSDNFRQSSIQGVMKRVKAKGATVVIYEPALKDgETFFGSKVINDLEQFKAMCDSIIANRYDTCLDDIKEK 406
Cdd:PRK15057  300 GIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPVMKE-DSFFNSRLERDLATFKQQADVIISNRMAEELKDVADK 378

                         410
                  ....*....|
gi 1752924942 407 VYTRDIFQRD 416
Cdd:PRK15057  379 VYTRDLFGSD 388
NDP-sugDHase TIGR03026
nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent ...
 6-395 3.90e-108

nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase (1.1.1.22), GDP-mannose 6-dehydrogenase (1.1.1.132), UDP-N-acetylglucosamine 6-dehydrogenase (1.1.1.136), UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase, and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose. All of these enzymes contain three Pfam domains, pfam03721, pfam00984, and pfam03720 for the N-terminal, central, and C-terminal regions respectively.


Pssm-ID: 274399 [Multi-domain]  Cd Length: 409  Bit Score: 324.56  E-value: 3.90e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   6 NIAVAGTGYVGLSIATLLA-QHHQVTAVDIIPEKIELINKRKSPIQDEYIEKYLTE--KELDLTATLDARSAYKSADFVV 82
Cdd:TIGR03026   2 KIAVIGLGYVGLPLAALLAdLGHDVTGVDIDQEKVDKLNKGKSPIYEPGLDELLAKalKAGRLRATTDYEEAIRDADVII 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942  83 IATPTNYDSRtQHFDTSAVESVIEVVMDV-NPDTIMVIKSTIPVGYTESVR----ETTGSK-----NIIFSPEFLRESKA 152
Cdd:TIGR03026  82 ICVPTPLKED-GSPDLSYVESAAETIAKHlRKGATVVLESTVPPGTTEEVVkpilERSGLKlgedfYLAYNPEFLREGNA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 153 LYDNLYPSRIIVGTDMtderllNAAHVFATLLQkSAIKENVdtLFMGFTEAEAVKLFANTYLALRVSYFNELDTYAEMKG 232
Cdd:TIGR03026 161 VHDLLHPDRIVGGETE------EAGEAVAELYS-PIIDGPV--LVTSIETAEMIKLAENTFRAVKIAFANELARICEALG 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 233 LNTQQIINGVCLDPRIGTHYNNPSFGYGGYCLPKDTKQLLANYAD--VPGNLIEAIVESNRTRKDFIADRVLQMAGyyny 310
Cdd:TIGR03026 232 IDVYEVIEAAGTDPRIGFNFLNPGPGVGGHCIPKDPLALIAKAKElgYNPELIEAAREINDSQPDYVVEKIKDLLG---- 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 311 aeynqyDVNRENpvlIGIYRLTMKSNSDNFRQSSIQGVMKRVKAKGATVVIYEPALKDgETFFGSKVINDLEQFKAMCDS 390
Cdd:TIGR03026 308 ------PLKGKT---VLILGLAFKPNTDDVRESPALDIIELLKEKGAKVKAYDPLVPE-EEVKGLPSIDDLEEALKGADA 377


                  ....*
gi 1752924942 391 IIANR 395
Cdd:TIGR03026 378 LVILT 382
Ugd COG1004
UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];
6-377 1.13e-70

UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440628 [Multi-domain]  Cd Length: 436  Bit Score: 228.75  E-value: 1.13e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   6 NIAVAGTGYVGLSIATLLAQH-HQVTAVDIIPEKIELINKRKSPIQ----DEYIEKYLTEKELdlTATLDARSAYKSADF 80
Cdd:COG1004     2 KIAVIGTGYVGLVTAACLAELgHEVTCVDIDEEKIEALNAGEIPIYepglEELVARNVAAGRL--RFTTDLAEAVAEADV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942  81 VVIA--TPTNYDSrtqHFDTSAVESVIEVVMDV-NPDTIMVIKSTIPVGYTESVRET----TGSKNIIFS----PEFLRE 149
Cdd:COG1004    80 VFIAvgTPSDEDG---SADLSYVLAAARSIGEAlKGYKVVVTKSTVPVGTADRVRAIiaeeLRGAGVDFDvvsnPEFLRE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 150 SKALYDNLYPSRIIVGTDmtDERllnAAHVFATLLqKSAIKENVDTLFMGFTEAEAVKLFANTYLALRVSYFNELDTYAE 229
Cdd:COG1004   157 GSAVEDFLRPDRIVIGVD--SER---AAEVLRELY-APFVRNGTPIIVTDLRSAELIKYAANAFLATKISFINEIANLCE 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 230 MKGLNTQQIINGVCLDPRIGTHYNNPSFGYGGYCLPKDTKQL--LANYADVPGNLIEAIVESNRTRKDFIADRVLQMAGy 307
Cdd:COG1004   231 KVGADVEEVARGIGLDSRIGPKFLYAGIGYGGSCFPKDVRALiaTARELGYDLRLLEAVEEVNERQKRRLVEKIREHLG- 309

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1752924942 308 ynyaeynqYDVNRENpvlIGIYRLTMKSNSDNFRQSSIQGVMKRVKAKGATVVIYEP-ALKDGETFFGSKV 377
Cdd:COG1004   310 --------GDLKGKT---IAVLGLAFKPNTDDMRESPALDIIEALLEAGARVRAYDPvAMENARRLLPDDI 369
UDPG_MGDP_dh_N pfam03721
UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose ...
 6-177 1.69e-34

UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 397677 [Multi-domain]  Cd Length: 186  Bit Score: 126.59  E-value: 1.69e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   6 NIAVAGTGYVGLSIATLLAQH-HQVTAVDIIPEKIELINKRKSPI----QDEYIEKYLTEKeldLTATLDARSAYKSADF 80
Cdd:pfam03721   2 KISVIGLGYVGLPTAACLAEIgHDVIGVDIDEEKVDKLNSGQIPIyepgLDELVKANVSGR---LSFTTDYSTAIEEADV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942  81 VVIATPTNYDSRTQHFDTSAVESVIEVVMDV-NPDTIMVIKSTIPVGYTESVRE---TTGSK------NIIFSPEFLRES 150
Cdd:pfam03721  79 IFIAVGTPSKKGGGAADLKYVESAARSIAPHlKKGKVVVVKSTVPVGTTENLVKpiiEEGGKkvgvdfDVASNPEFLREG 158

                         170       180
                  ....*....|....*....|....*..
gi 1752924942 151 KALYDNLYPSRIIVGtdMTDERLLNAA 177
Cdd:pfam03721 159 SAVYDLFNPDRVVIG--VTEKCAEAAL 183
UDPG_MGDP_dh_C smart00984
UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes ...
 327-413 2.33e-16

UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 214954 [Multi-domain]  Cd Length: 99  Bit Score: 74.08  E-value: 2.33e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942  327 GIYRLTMKSNSDNFRQSSIQGVMKRVKAKGATVVIYEP-ALKDGETFFGSKVINDLEQFKAMCDSIIANRYDT----CLD 401
Cdd:smart00984   1 AVLGLAFKPNTDDLRESPALDIIEELLEAGAEVVVYDPyAMEEAREYGLTYVSDLEEALKGADAVVIATEHDEfrslDPE 80

                           90
                   ....*....|....*...
gi 1752924942  402 DIKEK------VYTRDIF 413
Cdd:smart00984  81 ELKDLmkkpvvVDGRNIL 98
 
Name Accession Description Interval E-value
PRK15057 PRK15057
UDP-glucose 6-dehydrogenase; Provisional
 7-416 0e+00

UDP-glucose 6-dehydrogenase; Provisional


Pssm-ID: 185017 [Multi-domain]  Cd Length: 388  Bit Score: 553.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   7 IAVAGTGYVGLSIATLLAQHHQVTAVDIIPEKIELINKRKSPIQDEYIEKYLTEKELDLTATLDARSAYKSADFVVIATP 86
Cdd:PRK15057    3 ITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIATP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942  87 TNYDSRTQHFDTSAVESVIEVVMDVNPDTIMVIKSTIPVGYTESVRETTGSKNIIFSPEFLRESKALYDNLYPSRIIVGT 166
Cdd:PRK15057   83 TDYDPKTNYFNTSSVESVIKDVVEINPYAVMVIKSTVPVGFTAAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVIGE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 167 DmtDERllnaAHVFATLLQKSAIKENVDTLFMGFTEAEAVKLFANTYLALRVSYFNELDTYAEMKGLNTQQIINGVCLDP 246
Cdd:PRK15057  163 R--SER----AERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNTRQIIEGVCLDP 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 247 RIGTHYNNPSFGYGGYCLPKDTKQLLANYADVPGNLIEAIVESNRTRKDFIADRVLQmagyynyaeynqydvnrENPVLI 326
Cdd:PRK15057  237 RIGNHYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILS-----------------RKPQVV 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 327 GIYRLTMKSNSDNFRQSSIQGVMKRVKAKGATVVIYEPALKDgETFFGSKVINDLEQFKAMCDSIIANRYDTCLDDIKEK 406
Cdd:PRK15057  300 GIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPVMKE-DSFFNSRLERDLATFKQQADVIISNRMAEELKDVADK 378

                         410
                  ....*....|
gi 1752924942 407 VYTRDIFQRD 416
Cdd:PRK15057  379 VYTRDLFGSD 388
NDP-sugDHase TIGR03026
nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent ...
 6-395 3.90e-108

nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase (1.1.1.22), GDP-mannose 6-dehydrogenase (1.1.1.132), UDP-N-acetylglucosamine 6-dehydrogenase (1.1.1.136), UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase, and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose. All of these enzymes contain three Pfam domains, pfam03721, pfam00984, and pfam03720 for the N-terminal, central, and C-terminal regions respectively.


Pssm-ID: 274399 [Multi-domain]  Cd Length: 409  Bit Score: 324.56  E-value: 3.90e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   6 NIAVAGTGYVGLSIATLLA-QHHQVTAVDIIPEKIELINKRKSPIQDEYIEKYLTE--KELDLTATLDARSAYKSADFVV 82
Cdd:TIGR03026   2 KIAVIGLGYVGLPLAALLAdLGHDVTGVDIDQEKVDKLNKGKSPIYEPGLDELLAKalKAGRLRATTDYEEAIRDADVII 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942  83 IATPTNYDSRtQHFDTSAVESVIEVVMDV-NPDTIMVIKSTIPVGYTESVR----ETTGSK-----NIIFSPEFLRESKA 152
Cdd:TIGR03026  82 ICVPTPLKED-GSPDLSYVESAAETIAKHlRKGATVVLESTVPPGTTEEVVkpilERSGLKlgedfYLAYNPEFLREGNA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 153 LYDNLYPSRIIVGTDMtderllNAAHVFATLLQkSAIKENVdtLFMGFTEAEAVKLFANTYLALRVSYFNELDTYAEMKG 232
Cdd:TIGR03026 161 VHDLLHPDRIVGGETE------EAGEAVAELYS-PIIDGPV--LVTSIETAEMIKLAENTFRAVKIAFANELARICEALG 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 233 LNTQQIINGVCLDPRIGTHYNNPSFGYGGYCLPKDTKQLLANYAD--VPGNLIEAIVESNRTRKDFIADRVLQMAGyyny 310
Cdd:TIGR03026 232 IDVYEVIEAAGTDPRIGFNFLNPGPGVGGHCIPKDPLALIAKAKElgYNPELIEAAREINDSQPDYVVEKIKDLLG---- 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 311 aeynqyDVNRENpvlIGIYRLTMKSNSDNFRQSSIQGVMKRVKAKGATVVIYEPALKDgETFFGSKVINDLEQFKAMCDS 390
Cdd:TIGR03026 308 ------PLKGKT---VLILGLAFKPNTDDVRESPALDIIELLKEKGAKVKAYDPLVPE-EEVKGLPSIDDLEEALKGADA 377


                  ....*
gi 1752924942 391 IIANR 395
Cdd:TIGR03026 378 LVILT 382
Ugd COG1004
UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];
6-377 1.13e-70

UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440628 [Multi-domain]  Cd Length: 436  Bit Score: 228.75  E-value: 1.13e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   6 NIAVAGTGYVGLSIATLLAQH-HQVTAVDIIPEKIELINKRKSPIQ----DEYIEKYLTEKELdlTATLDARSAYKSADF 80
Cdd:COG1004     2 KIAVIGTGYVGLVTAACLAELgHEVTCVDIDEEKIEALNAGEIPIYepglEELVARNVAAGRL--RFTTDLAEAVAEADV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942  81 VVIA--TPTNYDSrtqHFDTSAVESVIEVVMDV-NPDTIMVIKSTIPVGYTESVRET----TGSKNIIFS----PEFLRE 149
Cdd:COG1004    80 VFIAvgTPSDEDG---SADLSYVLAAARSIGEAlKGYKVVVTKSTVPVGTADRVRAIiaeeLRGAGVDFDvvsnPEFLRE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 150 SKALYDNLYPSRIIVGTDmtDERllnAAHVFATLLqKSAIKENVDTLFMGFTEAEAVKLFANTYLALRVSYFNELDTYAE 229
Cdd:COG1004   157 GSAVEDFLRPDRIVIGVD--SER---AAEVLRELY-APFVRNGTPIIVTDLRSAELIKYAANAFLATKISFINEIANLCE 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 230 MKGLNTQQIINGVCLDPRIGTHYNNPSFGYGGYCLPKDTKQL--LANYADVPGNLIEAIVESNRTRKDFIADRVLQMAGy 307
Cdd:COG1004   231 KVGADVEEVARGIGLDSRIGPKFLYAGIGYGGSCFPKDVRALiaTARELGYDLRLLEAVEEVNERQKRRLVEKIREHLG- 309

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1752924942 308 ynyaeynqYDVNRENpvlIGIYRLTMKSNSDNFRQSSIQGVMKRVKAKGATVVIYEP-ALKDGETFFGSKV 377
Cdd:COG1004   310 --------GDLKGKT---IAVLGLAFKPNTDDMRESPALDIIEALLEAGARVRAYDPvAMENARRLLPDDI 369
WecC COG0677
UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell wall/membrane/envelope biogenesis];
7-392 1.36e-40

UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440441 [Multi-domain]  Cd Length: 413  Bit Score: 149.06  E-value: 1.36e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   7 IAVAGTGYVGLSIATLLAQH-HQVTAVDIIPEKIELINKRKSPIQ---DEYIEKYLTEKelDLTATLDArSAYKSADFVV 82
Cdd:COG0677     2 IAVIGLGYVGLPLAVAFAKAgFRVIGFDINPERVEELNAGEDPILepgDELLAEAVAAG--RLRATTDP-EALAEADVVI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942  83 IATPTNYDSRTQHfDTSAVESVIEVVMDV-NPDTIMVIKSTIPVGYTESV-----RETTGSK-----NIIFSPEflRES- 150
Cdd:COG0677    79 IAVPTPLDEDKEP-DLSYLESASETIAPHlKPGDLVVLESTVYPGTTEEVcvpilEKRSGLKagedfFLAYSPE--RINp 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 151 -KALYD--NlYPsRIIVGtdMTDERLLNAAHVFATLLQKSAIKenVDTLfmgfTEAEAVKLFANTYLALRVSYFNELDTY 227
Cdd:COG0677   156 gNKLHElrN-IP-KVVGG--ITPESAERAAALYGSVVTAGVVP--VSSI----KVAEAAKLIENTYRDVNIALANELALI 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 228 AEMKGLNTQQIINGvcldprIGTHYN----NPSFGYGGYCLPKDTKQLLANY--ADVPGNLIEAIVESNRTRKDFIADRV 301
Cdd:COG0677   226 CDRLGIDVWEVIEA------ANTKPGflifYPGPGVGGHCIPVDPYYLTWKAreLGYHPRLILAAREINDSMPEYVVERV 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 302 LQMagyynyaeYNQYDVNRENPVlIGIYRLTMKSNSDNFRQSSIQGVMKRVKAKGATVVIYEPALKDGETFFGSKVINDL 381
Cdd:COG0677   300 VKA--------LNEAGKSLKGAR-VLVLGLAYKENVDDLRESPALDIIEELREYGAEVDVHDPYVDEEEVEGEYGELVDL 370

                         410
                  ....*....|.
gi 1752924942 382 EQFKAMCDSII 392
Cdd:COG0677   371 EEALEGADAVV 381
UDPG_MGDP_dh_N pfam03721
UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose ...
 6-177 1.69e-34

UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 397677 [Multi-domain]  Cd Length: 186  Bit Score: 126.59  E-value: 1.69e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   6 NIAVAGTGYVGLSIATLLAQH-HQVTAVDIIPEKIELINKRKSPI----QDEYIEKYLTEKeldLTATLDARSAYKSADF 80
Cdd:pfam03721   2 KISVIGLGYVGLPTAACLAEIgHDVIGVDIDEEKVDKLNSGQIPIyepgLDELVKANVSGR---LSFTTDYSTAIEEADV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942  81 VVIATPTNYDSRTQHFDTSAVESVIEVVMDV-NPDTIMVIKSTIPVGYTESVRE---TTGSK------NIIFSPEFLRES 150
Cdd:pfam03721  79 IFIAVGTPSKKGGGAADLKYVESAARSIAPHlKKGKVVVVKSTVPVGTTENLVKpiiEEGGKkvgvdfDVASNPEFLREG 158

                         170       180
                  ....*....|....*....|....*..
gi 1752924942 151 KALYDNLYPSRIIVGtdMTDERLLNAA 177
Cdd:pfam03721 159 SAVYDLFNPDRVVIG--VTEKCAEAAL 183
UDPG_MGDP_dh pfam00984
UDP-glucose/GDP-mannose dehydrogenase family, central domain; The UDP-glucose/GDP-mannose ...
 202-291 5.74e-34

UDP-glucose/GDP-mannose dehydrogenase family, central domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 460015 [Multi-domain]  Cd Length: 92  Bit Score: 121.72  E-value: 5.74e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 202 EAEAVKLFANTYLALRVSYFNELDTYAEMKGLNTQQIINGVCLDPRIGTHYNNPSFGYGGYCLPKDTKQL--LANYADVP 279
Cdd:pfam00984   1 SAELIKLAENAFLAVKISFINELANLCEALGADVWEVIEAAGTDPRIGPKFLYPGPGVGGSCLPKDPRALiyLARELGVP 80

                          90
                  ....*....|..
gi 1752924942 280 GNLIEAIVESNR 291
Cdd:pfam00984  81 ARLLEAAREVNE 92
PLN02353 PLN02353
probable UDP-glucose 6-dehydrogenase
 7-267 8.23e-24

probable UDP-glucose 6-dehydrogenase


Pssm-ID: 177986 [Multi-domain]  Cd Length: 473  Bit Score: 102.83  E-value: 8.23e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   7 IAVAGTGYVG---LSIATLLAQHHQVTAVDIIPEKIELINKRKSPIQDEYIEKYLTE-KELDLTATLDARSAYKSAD--F 80
Cdd:PLN02353    4 ICCIGAGYVGgptMAVIALKCPDIEVVVVDISVPRIDAWNSDQLPIYEPGLDEVVKQcRGKNLFFSTDVEKHVAEADivF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942  81 VVIATPTnydsRTQHF------DTSAVESVIEVVMDVN-PDTIMVIKSTIPVGYTESVRE--TTGSKNIIF----SPEFL 147
Cdd:PLN02353   84 VSVNTPT----KTRGLgagkaaDLTYWESAARMIADVSkSDKIVVEKSTVPVKTAEAIEKilTHNSKGINFqilsNPEFL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 148 RESKALYDNLYPSRIIVGTDMTDERLLNA---AHVFATLLQKSAIkenvdtLFMGFTEAEAVKLFANTYLALRVSYFNEL 224
Cdd:PLN02353  160 AEGTAIEDLFKPDRVLIGGRETPEGQKAVqalKDVYAHWVPEERI------ITTNLWSAELSKLAANAFLAQRISSVNAM 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1752924942 225 DTYAEMKGLNTQQIINGVCLDPRIGTHYNNPSFGYGGYCLPKD 267
Cdd:PLN02353  234 SALCEATGADVSQVSHAVGKDSRIGPKFLNASVGFGGSCFQKD 276
UDPG_MGDP_dh_C smart00984
UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes ...
 327-413 2.33e-16

UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 214954 [Multi-domain]  Cd Length: 99  Bit Score: 74.08  E-value: 2.33e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942  327 GIYRLTMKSNSDNFRQSSIQGVMKRVKAKGATVVIYEP-ALKDGETFFGSKVINDLEQFKAMCDSIIANRYDT----CLD 401
Cdd:smart00984   1 AVLGLAFKPNTDDLRESPALDIIEELLEAGAEVVVYDPyAMEEAREYGLTYVSDLEEALKGADAVVIATEHDEfrslDPE 80

                           90
                   ....*....|....*...
gi 1752924942  402 DIKEK------VYTRDIF 413
Cdd:smart00984  81 ELKDLmkkpvvVDGRNIL 98
wecC PRK11064
UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional
 7-398 3.40e-12

UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional


Pssm-ID: 182940 [Multi-domain]  Cd Length: 415  Bit Score: 67.70  E-value: 3.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   7 IAVAGTGYVGLSIATLLAQHH-QVTAVDIIPEKIELINKRKSPIqdeyiekylTEKELDL---TAT----LDARSAYKSA 78
Cdd:PRK11064    6 ISVIGLGYIGLPTAAAFASRQkQVIGVDINQHAVDTINRGEIHI---------VEPDLDMvvkTAVeggyLRATTTPEPA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942  79 DFVVIATPTNYDSRTQHfDTSAVESVIEVVMDV-NPDTIMVIKSTIPVGYTESVRE-------------TTGSK---NII 141
Cdd:PRK11064   77 DAFLIAVPTPFKGDHEP-DLTYVEAAAKSIAPVlKKGDLVILESTSPVGATEQMAEwlaearpdltfpqQAGEQadiNIA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 142 FSPE------FLREskaLYDNlypSRIIVGtdMTDERLLNAAHVFATLLQKSAIKENVDTlfmgfteAEAVKLFANTYLA 215
Cdd:PRK11064  156 YCPErvlpgqVMVE---LIKN---DRVIGG--MTPVCSARASELYKIFLEGECVVTNSRT-------AEMCKLTENSFRD 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 216 LRVSYFNELDTYAEMKGLNTQQIINGVCLDPRIgthyN--NPSFGYGGYCLPKDTKQLLANYADvPGNLIEAIVESNRTR 293
Cdd:PRK11064  221 VNIAFANELSLICADQGINVWELIRLANRHPRV----NilQPGPGVGGHCIAVDPWFIVAQNPQ-QARLIRTAREVNDGK 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 294 KDFIADRVLQMAgyynyAEYNQYDVNRENPVLIGIYRLTMKSNSDNFRQSSIQGVMKRVKAK--GATVVIyEPALKDGET 371
Cdd:PRK11064  296 PHWVIDQVKAAV-----ADCLAATDKRASEVKIACFGLAFKPNIDDLRESPAMEIAELIAQWhsGETLVV-EPNIHQLPK 369

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 1752924942 372 FFGSKV-INDLE----------------QFKAMCDSIIANRY--DT 398
Cdd:PRK11064  370 KLDGLVtLVSLDealatadvlvmlvdhsQFKAINGDNVHQQWvvDT 415
UDPG_MGDP_dh_C pfam03720
UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; The UDP-glucose/GDP-mannose ...
 327-408 2.77e-09

UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 427462 [Multi-domain]  Cd Length: 103  Bit Score: 54.12  E-value: 2.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 327 GIYRLTMKSNSDNFRQSSIQGVMKRVKAKGATVVIYEPALKDGE---TFFGSKVINDLEQFKAMCDSIIANRYDTCLDDI 403
Cdd:pfam03720   1 AVLGLAFKPNTDDLRESPALDIIELLLEEGAEVKVYDPYVPEEAieaLGDGVTLVDDLEEALKGADAIVILTDHDEFKSL 80


                  ....*
gi 1752924942 404 KEKVY 408
Cdd:pfam03720  81 DWEKL 85
PRK15182 PRK15182
Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB;
7-364 2.20e-08

Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB;


Pssm-ID: 185104 [Multi-domain]  Cd Length: 425  Bit Score: 55.85  E-value: 2.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   7 IAVAGTGYVGLSIATLLAQHHQVTAVDIIPEKIeLINKRKSPIQDEYIEKYLTE-KELDLTATLDArsaYKSADFVVIAT 85
Cdd:PRK15182    9 IAIIGLGYVGLPLAVEFGKSRQVVGFDVNKKRI-LELKNGVDVNLETTEEELREaRYLKFTSEIEK---IKECNFYIITV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942  86 PTNYDSRTQHFDTSAVESVIEVVMDVNPDTIMVIKSTIPVGYTES--VRETTGSKNIIFSPEFlreskalYDNLYPSRII 163
Cdd:PRK15182   85 PTPINTYKQPDLTPLIKASETVGTVLNRGDIVVYESTVYPGCTEEecVPILARMSGMTFNQDF-------YVGYSPERIN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 164 VGTdmTDERLLNAAHVfaTLLQKSAIKENVDTLFMGFTEA-----------EAVKLFANTYLALRVSYFNELDTYAEMKG 232
Cdd:PRK15182  158 PGD--KKHRLTNIKKI--TSGSTAQIAELIDEVYQQIISAgtykaesikvaEAAKVIENTQRDLNIALVNELAIIFNRLN 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942 233 LNTQQIINGVcldpriGTHYNNPSFG---YGGYCLPKDTKQLLANYADVpGNLIEAIVESNRTRK---DFIADRVLQmag 306
Cdd:PRK15182  234 IDTEAVLRAA------GSKWNFLPFRpglVGGHCIGVDPYYLTHKSQGI-GYYPEIILAGRRLNDnmgNYVSEQLIK--- 303

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1752924942 307 yynyaEYNQYDVNRENPVLIgIYRLTMKSNSDNFRQSSIQGVMKRVKAKGATVVIYEP 364
Cdd:PRK15182  304 -----AMIKKGINVEGSSVL-ILGFTFKENCPDIRNTRIIDVVKELGKYSCKVDIFDP 355
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 6-90 1.34e-05

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 45.22  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   6 NIAVAGTGYVGLSIATLLAQH-HQVTAVDIIPEKIELINKRKSPIQDEYIEK-YLTEKELD-----LTATLDARSAyKSA 78
Cdd:pfam02737   1 KVAVIGAGTMGAGIAQVFALAgLEVVLVDISEEALEKALERIESSLERLVEKgRITEEEVDaalarISFTTDLAAA-VDA 79

                          90
                  ....*....|..
gi 1752924942  79 DFVVIATPTNYD 90
Cdd:pfam02737  80 DLVIEAVPENLE 91
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 7-87 3.21e-05

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 43.72  E-value: 3.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   7 IAVAGTGYVGLSIATLLAQH-HQVTAVDIIPEKIELIN-KRKSPiqdeyieKYLTEKEL--DLTATLDARSAYKSADFVV 82
Cdd:pfam01210   2 IAVLGAGSWGTALAKVLADNgHEVRLWGRDEELIEEINtTHENV-------RYLPGIKLpeNLKATTDLAEALKGADIIV 74


                  ....*
gi 1752924942  83 IATPT 87
Cdd:pfam01210  75 IVVPS 79
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
6-87 6.87e-05

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 44.67  E-value: 6.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   6 NIAVAGTGYVGLSIATLLAQH-HQVTAVDIIPEKIELINKRKSPiqdeyiEKYLTEKELD--LTATLDARSAYKSADFVV 82
Cdd:PRK00094    3 KIAVLGAGSWGTALAIVLARNgHDVTLWARDPEQAAEINADREN------PRYLPGIKLPdnLRATTDLAEALADADLIL 76


                  ....*
gi 1752924942  83 IATPT 87
Cdd:PRK00094   77 VAVPS 81
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 6-189 2.63e-04

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 42.40  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   6 NIAVAGTGYVGLSIATLLAQH-HQVTAVDIIPEKIELINKRKSPIQDEYIEKY-LTEKELD-----LTATLDArSAYKSA 78
Cdd:COG1250     4 KVAVIGAGTMGAGIAAVFANAgYEVVLLDISPEALERARARIAKLLDKLVKKGkLTEEEADaalarITPTTDL-AALADA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942  79 DFVVIATPTNYDSRTQHFdtSAVESVievvmdVNPDTIMVIK-STIPVgyTESVRETTGSKNII----FSPeflreskal 153
Cdd:COG1250    83 DLVIEAVPEDLDLKQEVF--AELDAV------APPDAILASNtSSLSI--TELAAATKRPERFIglhfFNP--------- 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1752924942 154 ydnlyPSRI----IVGTDMTDERLLNAAHVFATLLQKSAI 189
Cdd:COG1250   144 -----VPLMplveVIRGPATSDETVATAVAFARRLGKTPV 178
YwnB COG2910
Putative NADH-flavin reductase [General function prediction only];
6-156 2.98e-04

Putative NADH-flavin reductase [General function prediction only];


Pssm-ID: 442154 [Multi-domain]  Cd Length: 205  Bit Score: 41.77  E-value: 2.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   6 NIAVAG-TGYVGLSIAT-LLAQHHQVTAV--DiiPEKIELINKRkspiqdeyiekyLTEKELDLTATLDARSAYKSADFV 81
Cdd:COG2910     1 KIAVIGaTGRVGSLIVReALARGHEVTALvrN--PEKLPDEHPG------------LTVVVGDVLDPAAVAEALAGADAV 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1752924942  82 VIATPTNyDSRTQHFDTSAVESVIEVVMDVNPDTIMVIkSTIPVGYTESVRETtgskniiFSPEFLRESKALYDN 156
Cdd:COG2910    67 VSALGAG-GGNPTTVLSDGARALIDAMKAAGVKRLIVV-GGAGSLDVAPGLGL-------DTPGFPAALKPAAAA 132
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
1-30 2.74e-03

Predicted flavin-containing amine oxidase [General function prediction only];


Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 39.71  E-value: 2.74e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1752924942   1 MKKKyNIAVAGTGYVGLSIATLLAQHHQVT 30
Cdd:COG2907     1 MARM-RIAVIGSGISGLTAAWLLSRRHDVT 29
PRK06035 PRK06035
3-hydroxyacyl-CoA dehydrogenase; Validated
 6-117 5.35e-03

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 180361 [Multi-domain]  Cd Length: 291  Bit Score: 38.70  E-value: 5.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   6 NIAVAGTGYVGLSIATLLAQH-HQVTAVD----IIPEKIELINKRKSPIQDEYIEKYLTEKELDLT----ATLDARSAYK 76
Cdd:PRK06035    5 VIGVVGSGVMGQGIAQVFARTgYDVTIVDvseeILKNAMELIESGPYGLRNLVEKGKMSEDEAKAImariRTSTSYESLS 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1752924942  77 SADFVVIATPTNYDSRTQHFdtsavesvIEVVMDVNPDTIM 117
Cdd:PRK06035   85 DADFIVEAVPEKLDLKRKVF--------AELERNVSPETII 117
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 7-49 7.27e-03

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 36.35  E-value: 7.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1752924942   7 IAVAGTGYVGLSIATLLAQHHQVTAVDIIPEKIELINKRKSPI 49
Cdd:pfam02254   1 IIIIGYGRVGRSLAEELSEGGDVVVIDKDEERVEELREEGVPV 43
PRK08293 PRK08293
3-hydroxyacyl-CoA dehydrogenase;
6-96 7.47e-03

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 181359 [Multi-domain]  Cd Length: 287  Bit Score: 38.00  E-value: 7.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752924942   6 NIAVAGTGYVGLSIATLLAQH-HQVTAVDIIPEKIELINKRKSPIQDEYI-EKYLTEKEL------DLTATLDARSAYKS 77
Cdd:PRK08293    5 NVTVAGAGVLGSQIAFQTAFHgFDVTIYDISDEALEKAKERIAKLADRYVrDLEATKEAPaeaalnRITLTTDLAEAVKD 84

                          90
                  ....*....|....*....
gi 1752924942  78 ADFVVIATPTNYDSRTQHF 96
Cdd:PRK08293   85 ADLVIEAVPEDPEIKGDFY 103
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 6-49 7.61e-03

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 38.12  E-value: 7.61e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1752924942   6 NIAVAGTGYVGLSIA-TLLAQHHQVTAVDIIPEKIELINKRKSPI 49
Cdd:COG0569    97 HVIIIGAGRVGRSLArELEEEGHDVVVIDKDPERVERLAEEDVLV 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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