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Conserved domains on  [gi|1751532519|gb|QEV77700|]
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galactokinase [Streptomyces rimosus]

Protein Classification

galactokinase( domain architecture ID 11414964)

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
14-409 3.16e-180

Galactokinase [Carbohydrate transport and metabolism];


:

Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 506.62  E-value: 3.16e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  14 RARHTADRFREVYGAAPAGVWAAPGRVNLIGEHTDYNDGFVMPLALPHTTLAAAAPRTDGVLRVHSGDGSGggqTVELRL 93
Cdd:COG0153     1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDE---EVEFDL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  94 DALRPAADGGWAGYPAGVAWALRDAGLPVGGADLHYESTVPVGAGLSSSAALEVATALALDDLYGLGLTRQRLAQLAQRA 173
Cdd:COG0153    78 DDLEPGEEDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 174 ENAFVGVPCGIMDQTAAACCTDGHALFLDTRDLAQRQVPFDLagEGLRLLVVDTRVKHELGDGAYAQRRAMCERGARALG 253
Cdd:COG0153   158 ENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPL--EGYALVIVDTNVKHSLADSEYNERRAECEAAAAILG 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 254 VHALRDVPYAHLPEALDKLaaTDEEpgggkgdggpgTAAVVRHVVTENRRVEEVIARLDAGEARAIGPLLTAGHASLRDD 333
Cdd:COG0153   236 VKSLRDVTLEDLEAARARL--GDEV-----------LRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDD 302

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1751532519 334 FRVSCAELDLAVEAAGAAGALG-ARMTGGGFGGSAIVLVEETDADAVAVRITEAFAAAGHTAPRIFPAVPSAGARRL 409
Cdd:COG0153   303 YEVSCPELDTLVELALAEAGVLgARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARRL 379
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
14-409 3.16e-180

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 506.62  E-value: 3.16e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  14 RARHTADRFREVYGAAPAGVWAAPGRVNLIGEHTDYNDGFVMPLALPHTTLAAAAPRTDGVLRVHSGDGSGggqTVELRL 93
Cdd:COG0153     1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDE---EVEFDL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  94 DALRPAADGGWAGYPAGVAWALRDAGLPVGGADLHYESTVPVGAGLSSSAALEVATALALDDLYGLGLTRQRLAQLAQRA 173
Cdd:COG0153    78 DDLEPGEEDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 174 ENAFVGVPCGIMDQTAAACCTDGHALFLDTRDLAQRQVPFDLagEGLRLLVVDTRVKHELGDGAYAQRRAMCERGARALG 253
Cdd:COG0153   158 ENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPL--EGYALVIVDTNVKHSLADSEYNERRAECEAAAAILG 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 254 VHALRDVPYAHLPEALDKLaaTDEEpgggkgdggpgTAAVVRHVVTENRRVEEVIARLDAGEARAIGPLLTAGHASLRDD 333
Cdd:COG0153   236 VKSLRDVTLEDLEAARARL--GDEV-----------LRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDD 302

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1751532519 334 FRVSCAELDLAVEAAGAAGALG-ARMTGGGFGGSAIVLVEETDADAVAVRITEAFAAAGHTAPRIFPAVPSAGARRL 409
Cdd:COG0153   303 YEVSCPELDTLVELALAEAGVLgARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARRL 379
PRK03817 PRK03817
galactokinase; Provisional
 36-410 1.56e-108

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 323.10  E-value: 1.56e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  36 APGRVNLIGEHTDYNDGFVMPLALP-HTTLAAaapRTDGVLRVHSgdgSGGGQTVELRLDALRPAADggWAGYPAGVAWA 114
Cdd:PRK03817    5 SPGRVNLIGEHTDYNDGYVLPFAINlYTFLEI---EKSEKFIFYS---ENFNEEKTFELDKLEKLNS--WADYIKGVIWV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 115 LRDAGLPVGGADLHYESTVPVGAGLSSSAALEVATALALDDLYGLGLTRQRLAQLAQRAENAFVGVPCGIMDQTAAACCT 194
Cdd:PRK03817   77 LEKRGYEVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENEFVGVPCGIMDQFAVAFGK 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 195 DGHALFLDTRDLAQRQVPFDlagEGLRLLVVDTRVKHELGDGAYAQRRAMCERGARALGVHALRDVPYA---HLPEALDK 271
Cdd:PRK03817  157 KDHAIFLDTMTLEYEYVPFP---EDYEILVFDTGVKRELASSEYNERRQECEEALKILGKKSSKEVTEEdlsKLPPLLRK 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 272 LAatdeepgggkgdggpgtaavvRHVVTENRRVEEVIARLDAGEARAIGPLLTAGHASLRDDFRVSCAELDLAVEAAGAA 351
Cdd:PRK03817  234 RA---------------------GYVLRENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALEL 292

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1751532519 352 GALGARMTGGGFGGSAIVLVEETDADAVAVRITEAFAAAGHTAPRIFPAVPSAGARRLV 410
Cdd:PRK03817  293 GAYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYKKRFGIDPKYFVVESSDGVRKIE 351
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 18-409 3.32e-84

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 262.07  E-value: 3.32e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  18 TADRFREVYGAAPAGVWAAPGRVNLIGEHTDYNDGFVMPLALPHTTLAAAAPRTDGVLRVHSGDGSGggQTVELRLDALR 97
Cdd:TIGR00131   4 IQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADN--KFAERSLDLPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  98 PAADGG-WAGYPAGVAWALRDAGLPVG-GADLHYESTVPVGAGLSSSAALEVATALALDDLYGLGLTRQRLAQLAQRAEN 175
Cdd:TIGR00131  82 DGSEVSdWANYFKGVLHVAQERFNSFPlGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQVAEN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 176 AFVGVPCGIMDQTAAACCTDGHALFLDTRDLaqRQVPFDLAGEGLRLLVVDTRVKHELGDGAYAQRRAMCERGARALGV- 254
Cdd:TIGR00131 162 HFVGVNCGIMDQAASVLGKEDHALLVECRSL--KATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAAt 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 255 --HALRDVPYAHLPEALDKLAATDEEpgggkgdggpgTAAVVRHVVTENRRVEEVIARLDAGEARAIGPLLTAGHASLRD 332
Cdd:TIGR00131 240 dkGALRDFMNEYFARYIARLTKMLPL-----------VEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDD 308

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1751532519 333 DFRVSCAELDLAVEAAGAAG-ALGARMTGGGFGGSAIVLVEETDADAVAVRITEAFAAAGHTAPRIFPAVPSAGARRL 409
Cdd:TIGR00131 309 DYECTCPEIDELVCSAALVNgSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSKPGAGSC 386
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 21-69 5.73e-22

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.89  E-value: 5.73e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1751532519  21 RFREVYGAAPAGVWAAPGRVNLIGEHTDYNDGFVMPLALPHTTLAAAAP 69
Cdd:pfam10509   2 AFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
14-409 3.16e-180

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 506.62  E-value: 3.16e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  14 RARHTADRFREVYGAAPAGVWAAPGRVNLIGEHTDYNDGFVMPLALPHTTLAAAAPRTDGVLRVHSGDGSGggqTVELRL 93
Cdd:COG0153     1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDE---EVEFDL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  94 DALRPAADGGWAGYPAGVAWALRDAGLPVGGADLHYESTVPVGAGLSSSAALEVATALALDDLYGLGLTRQRLAQLAQRA 173
Cdd:COG0153    78 DDLEPGEEDGWANYVRGVAWALQERGYKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 174 ENAFVGVPCGIMDQTAAACCTDGHALFLDTRDLAQRQVPFDLagEGLRLLVVDTRVKHELGDGAYAQRRAMCERGARALG 253
Cdd:COG0153   158 ENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPL--EGYALVIVDTNVKHSLADSEYNERRAECEAAAAILG 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 254 VHALRDVPYAHLPEALDKLaaTDEEpgggkgdggpgTAAVVRHVVTENRRVEEVIARLDAGEARAIGPLLTAGHASLRDD 333
Cdd:COG0153   236 VKSLRDVTLEDLEAARARL--GDEV-----------LRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDD 302

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1751532519 334 FRVSCAELDLAVEAAGAAGALG-ARMTGGGFGGSAIVLVEETDADAVAVRITEAFAAAGHTAPRIFPAVPSAGARRL 409
Cdd:COG0153   303 YEVSCPELDTLVELALAEAGVLgARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARRL 379
PRK03817 PRK03817
galactokinase; Provisional
 36-410 1.56e-108

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 323.10  E-value: 1.56e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  36 APGRVNLIGEHTDYNDGFVMPLALP-HTTLAAaapRTDGVLRVHSgdgSGGGQTVELRLDALRPAADggWAGYPAGVAWA 114
Cdd:PRK03817    5 SPGRVNLIGEHTDYNDGYVLPFAINlYTFLEI---EKSEKFIFYS---ENFNEEKTFELDKLEKLNS--WADYIKGVIWV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 115 LRDAGLPVGGADLHYESTVPVGAGLSSSAALEVATALALDDLYGLGLTRQRLAQLAQRAENAFVGVPCGIMDQTAAACCT 194
Cdd:PRK03817   77 LEKRGYEVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENEFVGVPCGIMDQFAVAFGK 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 195 DGHALFLDTRDLAQRQVPFDlagEGLRLLVVDTRVKHELGDGAYAQRRAMCERGARALGVHALRDVPYA---HLPEALDK 271
Cdd:PRK03817  157 KDHAIFLDTMTLEYEYVPFP---EDYEILVFDTGVKRELASSEYNERRQECEEALKILGKKSSKEVTEEdlsKLPPLLRK 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 272 LAatdeepgggkgdggpgtaavvRHVVTENRRVEEVIARLDAGEARAIGPLLTAGHASLRDDFRVSCAELDLAVEAAGAA 351
Cdd:PRK03817  234 RA---------------------GYVLRENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALEL 292

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1751532519 352 GALGARMTGGGFGGSAIVLVEETDADAVAVRITEAFAAAGHTAPRIFPAVPSAGARRLV 410
Cdd:PRK03817  293 GAYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYKKRFGIDPKYFVVESSDGVRKIE 351
PRK05101 PRK05101
galactokinase; Provisional
 17-409 9.46e-100

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 301.84  E-value: 9.46e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  17 HTADRFREVYGAAPAGVWAAPGRVNLIGEHTDYNDGFVMPLALPHTTLAAAAPRTDGVLRVHSGDGsgGGQTVELRLDA- 95
Cdd:PRK05101    6 KTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIAADY--DNQQDEFSLDAp 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  96 LRPAADGGWAGYPAGVAWALRDAGLPVGGADLHYESTVPVGAGLSSSAALEVATALALDDLYGLGLTRQRLAQLAQRAEN 175
Cdd:PRK05101   84 IVPHPEQQWANYVRGVVKHLQERNPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEIALNGQEAEN 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 176 AFVGVPCGIMDQTAAACCTDGHALFLDTRDLAQRQVPFDlagEGLRLLVVDTRVKHELGDGAYAQRRAMCERGARALGVH 255
Cdd:PRK05101  164 QFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMP---EGVAVVIINSNVKRGLVDSEYNTRRQQCETAARFFGVK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 256 ALRDVPYAHLPEALDKLaatDEEpgggkgdggpgTAAVVRHVVTENRRVEEVIARLDAGEARAIGPLLTAGHASLRDDFR 335
Cdd:PRK05101  241 ALRDVTLEQFNAVAAEL---DPV-----------VAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFE 306

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1751532519 336 VSCAELDLAVEAAGAAGALG--ARMTGGGFGGSAIVLVEETDADAVAVRITEAFAAAGHTAPRIFPAVPSAGARRL 409
Cdd:PRK05101  307 ITVPQIDTLVEIVKAVIGDQggVRMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKTGLKETFYVCKASQGAGQC 382
PRK05322 PRK05322
galactokinase; Provisional
 20-409 7.18e-97

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 294.84  E-value: 7.18e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  20 DRFREVYGAAPAGVWAAPGRVNLIGEHTDYNDGFVMPLALPHTTLAAAAPRTDGVLRVHSGDGSGGGqTVELRLDALRPA 99
Cdd:PRK05322    8 KKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSANFEDLG-IIEFDLDDLSFD 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 100 ADGGWAGYPAGVAWALRDAGLPV-GGADLHYESTVPVGAGLSSSAALEVATALALDDLYGLGLTRQRLAQLAQRAENAFV 178
Cdd:PRK05322   87 KEDDWANYPKGVLKFLQEAGYKIdHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQKTENEFI 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 179 GVPCGIMDQTAAACCTDGHALFLDTRDLAQRQVPFDLagEGLRLLVVDTRVKHELGDGAYAQRRAMCERG----ARALGV 254
Cdd:PRK05322  167 GVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDL--GDYVIVIMNTNKRRELADSKYNERRAECEKAleelQKKLDI 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 255 HALRDVPyahlPEALDKLAA--TDEEPGGGkgdggpgtaavVRHVVTENRRVEEVIARLDAGEARAIGPLLTAGHASLRD 332
Cdd:PRK05322  245 KSLGELT----EEEFDEYSYliKDETLLKR-----------ARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRD 309

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1751532519 333 DFRVSCAELD-LAVEAAGAAGALGARMTGGGFGGSAIVLVEETDADAVAVRITEAFAAAGHTAPRIFPAVPSAGARRL 409
Cdd:PRK05322  310 DYEVTGLELDtLVEAAWKQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKIGYAASFYVAEIGDGAREL 387
PRK00555 PRK00555
galactokinase; Provisional
 34-406 1.83e-88

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 272.50  E-value: 1.83e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  34 WAAPGRVNLIGEHTDYNDGFVMPLALPHTTLAAAAPRTDGVLRVHSGDGSGggqTVELRLDALrPAADGGWAGYPAGVAW 113
Cdd:PRK00555    5 YAAPGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTDAITASSDRADG---SARIPLDTT-PGQVTGWAAYAAGVIW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 114 ALRDAGLPVGGADLHYESTVPVGAGLSSSAALEVATALALDDLYGLGLTRQRLAQLAQRAENAFVGVPCGIMDQTAAACC 193
Cdd:PRK00555   81 ALRGAGHPVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLAQRAENEYVGAPTGLLDQLAALFG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 194 TDGHALFLDTRDLAQRQVPFDLAGEGLRLLVVDTRVKHELGDGAYAQRRAMCERGARALGVHALRDVPyahlPEALDKLA 273
Cdd:PRK00555  161 APKTALLIDFRDLTVRPVAFDPDAAGVVLLLMDSRARHRHAGGEYAARRASCERAAADLGVSSLRAVQ----DRGLAALG 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 274 ATDEepgggkgdggPGTAAVVRHVVTENRRVEEVIARLDAGEARAIGPLLTAGHASLRDDFRVSCAELDLAVEAAGAAGA 353
Cdd:PRK00555  237 AIAD----------PIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHASMRDDFEITTERIDLIADSAVRAGA 306

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1751532519 354 LGARMTGGGFGGSAIVLVEETDADAVAVRITEAFAAAGHTAPRIFPAVPSAGA 406
Cdd:PRK00555  307 LGARMTGGGFGGCVIALVPADRAEDVADTVRRAAVTAGYPEPAVSRTYAAPGA 359
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 18-409 3.32e-84

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 262.07  E-value: 3.32e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  18 TADRFREVYGAAPAGVWAAPGRVNLIGEHTDYNDGFVMPLALPHTTLAAAAPRTDGVLRVHSGDGSGggQTVELRLDALR 97
Cdd:TIGR00131   4 IQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADN--KFAERSLDLPL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  98 PAADGG-WAGYPAGVAWALRDAGLPVG-GADLHYESTVPVGAGLSSSAALEVATALALDDLYGLGLTRQRLAQLAQRAEN 175
Cdd:TIGR00131  82 DGSEVSdWANYFKGVLHVAQERFNSFPlGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQVAEN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 176 AFVGVPCGIMDQTAAACCTDGHALFLDTRDLaqRQVPFDLAGEGLRLLVVDTRVKHELGDGAYAQRRAMCERGARALGV- 254
Cdd:TIGR00131 162 HFVGVNCGIMDQAASVLGKEDHALLVECRSL--KATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAAt 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 255 --HALRDVPYAHLPEALDKLAATDEEpgggkgdggpgTAAVVRHVVTENRRVEEVIARLDAGEARAIGPLLTAGHASLRD 332
Cdd:TIGR00131 240 dkGALRDFMNEYFARYIARLTKMLPL-----------VEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDD 308

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1751532519 333 DFRVSCAELDLAVEAAGAAG-ALGARMTGGGFGGSAIVLVEETDADAVAVRITEAFAAAGHTAPRIFPAVPSAGARRL 409
Cdd:TIGR00131 309 DYECTCPEIDELVCSAALVNgSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSKPGAGSC 386
PTZ00290 PTZ00290
galactokinase; Provisional
 36-406 1.02e-34

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 133.79  E-value: 1.02e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  36 APGRVNLIGEHTDYNDGFVMPLAL---PHTTLAAAAPRTDGVLRVHSGDGSgggqtvELRLDALRPAA-DGGWAGYPAG- 110
Cdd:PTZ00290   42 APGRVNFIGEHVDYMGGYVCPAAVlegCHILVGRVKHFCDHKLRFATETDE------HFVLDHLGGAKhNKAWTTFVRGa 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 111 VAWALRDAGLPVGGADLH-----YESTVPVGAGLSSSAALEVATALALDDL---------YGLG--------LTRQRLAQ 168
Cdd:PTZ00290  116 ATLRLNRLGVAIDAPSLQgvcmvVHGTLPMGAGMSASASFGVALLNAINTVvtrrykgcpTSPGrrysilppMSKEELIE 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 169 LAQRA---ENAFVGVPCGIMDQTAAACCTDGHALFLDTRDLAQRQVPFD-LAGEGLRLLVVDTRVKHEL---GDGAYAQR 241
Cdd:PTZ00290  196 LAKQArriETEFCGVNVGIMDQFISAFAEEDKFMFLDCKSLTFESHDMTpLLGDGACFLLIDSMIKHDLlggTAGMYNTV 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 242 RAMCERGARALGVHALRDVPYAHlpealdKLAATDEEPGGGKGDGGPGTAAVVRHV-----------VTENRRVEEVIAR 310
Cdd:PTZ00290  276 RSDQEGAQKKIGKHRYRGKPFTF------SDLVRNPKKYTFDGDVVAFMESCKPLMtpgefergtynIMEQIRTLEFIKL 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 311 LDAG-------EARAIGPLLTAGHASLRDDFRVSCAELDLAVEA-AGAAGALGARMTGGGFGGSAIVLVEETDADAVAVR 382
Cdd:PTZ00290  350 NDPElplsreeRFRKAGEILNAGHQGMRDLMKITTPELDFIHELiNEEKGVAGGRMMGGGFGGCIILLLKKNAVDRVVAH 429

                         410       420
                  ....*....|....*....|....
gi 1751532519 383 ITEAFAAAGHTAPRIFPAVPSAGA 406
Cdd:PTZ00290  430 VREKFKARFGVENDVYPVVAGDGA 453
PLN02521 PLN02521
galactokinase
 11-406 8.71e-30

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 120.20  E-value: 8.71e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  11 DAARAR--HTADRFREVYGAAPAGVWAAPGRVNLIGEHTDYNDGFVMPLALPHTTLAAAAPRT-DGVLRVHSGDGSGGGQ 87
Cdd:PLN02521   26 EEARLRyaRLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEgSKKLRIANVNDKYTTC 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  88 TVELRLDALRPAADGGWAGY----PAGVAWALRDAGLPVG---GADLHYESTVPVGAGLSSSAALEVATALALDDLYGLG 160
Cdd:PLN02521  106 TFPADPDQEVDLANHKWGNYficgYKGVFEFLKSKGVDVGppvGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLN 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 161 LTRQRLAQLAQRAENaFVGVPCGIMDQTAAACCTDGHALFLDTRDLaqRQVPFDLAGEGLRLLVVDTRV--KHELGDGAY 238
Cdd:PLN02521  186 FTKKEVAQFTCKCER-HIGTQSGGMDQAISIMAQQGVAKLIDFNPV--RATDVQLPAGGTFVIANSLAEsnKAVTAATNY 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 239 AQRRAMCERGARALG-------------VHALRDV-----PYAHLPEALDKLAATDE-----------------EPGGGK 283
Cdd:PLN02521  263 NNRVVECRLAAIVLAvklgmsaeeaiskVKTLSDVeglcvSFAGSHGSSDPAVAVKEllhegpytaeeieeilgESLTSI 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 284 GDGGPGTAAVVR------------HVVTENRRV----EEVIARLDAGEA-RAIGPLLTAGHASLRDDFRVSCAELDLAVE 346
Cdd:PLN02521  343 FKNSPTSLAVLKaakhfklhqravHVYSEAKRVhafrDTVSSSLSEEEKlKKLGDLMNESHYSCSVLYECSCPELEELVK 422

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1751532519 347 AAGAAGALGARMTGGGFGGSAIVLVEETDADAVAVRITEAFAAAGHTAPRI---------FPAVPSAGA 406
Cdd:PLN02521  423 VCRDNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKSRIEKGVIkeedlglyvFASKPSSGA 491
PLN02865 PLN02865
galactokinase
 33-390 4.56e-27

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 111.82  E-value: 4.56e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  33 VWAAPGRVNLIGEHTDYNDGFVMPLALPHTTLAAAAPRTDGVLRVHSGDGSGggqTVELRLDALR---------PAADGG 103
Cdd:PLN02865   32 VVVSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLRSAQFEG---EVRFRVDEIQhpianvssdSKEESN 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 104 WAGYPAGVAWALRDAGLPVGGADLHYESTVP--VGAGLSSSAALEVATALALDDLYGLGLTRQRLAQLAQRAENAFVGVP 181
Cdd:PLN02865  109 WGDYARGAVYALQSRGHALSQGITGYISGSEglDSSGLSSSAAVGVAYLLALENANNLTVSPEDNIELDRLIENEYLGLR 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 182 CGIMDQTAAACCTDGHALFLDTRDLAQRQVPFDLAGEGL----RLLVVDTRVKHEL-GDGAYAQRRAMCERGARAL---- 252
Cdd:PLN02865  189 NGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQPGGekpfKILLAFSGLRHALtNKPGYNLRVSECQEAARFLleas 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 253 GVHALRDVPYAHLPEALDKLAATDEEPGggkgdggpgtAAVVRHVVTENRRVEEVIARLDAGEARAIGPLLTAGHASLRD 332
Cdd:PLN02865  269 GNDELEPLLCNVEPEVYEAHKCKLEAVL----------ARRAEHYFSENMRVIKGVEAWASGNLEEFGKLISASGLSSIE 338

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1751532519 333 DFRVSCAEL-DLAVEAAGAAGALGARMTGGGFGGSAIVLVEETDADAVAVRITEAFAAA 390
Cdd:PLN02865  339 NYECGCEPLiQLYEILLKAPGVYGARFSGAGFRGCCVAFVDAEMAEEAASFVRDEYEKA 397
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 36-371 1.86e-25

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 104.54  E-value: 1.86e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  36 APGRVNLIGEHTDYNDGFVMPLALPHTTLAAAAPRTDGVLRVHSGDGSGGGQTVELRLDALRPAAdggwagypAGVAWAL 115
Cdd:COG1577     1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKLRIESPDLGGTLDLDPLADAALRYIK--------AAIEAAL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 116 RDAGLPVGGADLHYESTVPVGAGLSSSAALEVATALALDDLYGLGLTRQRLAQLAQRAENAFVGVPCGiMDqtaAACCTD 195
Cdd:COG1577    73 EYLGLPLKGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFYGVELSKEELFKLALEAEKIVHGNPSG-LD---TAASTY 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 196 GHALFLDTRDlaqRQVPFDLaGEGLRLLVVDTrvkhelgdGAYAQRRAMCERgaralgVHALRDVPYAHLPEALDKLAAT 275
Cdd:COG1577   149 GGPIYYQRGD---RAEPLEL-PKNLPLVVGDT--------GVPASTKELVAK------VRKLKERNPELYEAFLEEIGDL 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 276 deepgggkgdggpgtaavvrhvvtenrrVEEVIARLDAGEARAIGPLLTAGHAsLRDDFRVSCAELDLAVEAAGAAGALG 355
Cdd:COG1577   211 ----------------------------VEEAIEALEEGDLEALGELMNENHG-LLRALGVSTPELDRLVEAARKAGALG 261

                         330
                  ....*....|....*.
gi 1751532519 356 ARMTGGGFGGSAIVLV 371
Cdd:COG1577   262 AKLTGAGGGGCVIALA 277
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 21-69 5.73e-22

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.89  E-value: 5.73e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1751532519  21 RFREVYGAAPAGVWAAPGRVNLIGEHTDYNDGFVMPLALPHTTLAAAAP 69
Cdd:pfam10509   2 AFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 36-370 1.18e-20

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 90.81  E-value: 1.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519  36 APGRVNLIGEHtdyndgfvmplALPHTTLAAAAP---RTDGVLRVHSGDGSGGGQTVELRLDALRPAADGGWAGYPAGVA 112
Cdd:TIGR00549   1 APGKIILFGEH-----------AVVYGEPAIAAPiplRTTVTVIESSDGSFIESDLGRGSLDDAPDELDGLKYVLAEFLS 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 113 WALRDAGLPVggaDLHYESTVPVGAGLSSSAALEVATALALDDLYGLGLTRQRLAQLAQRAENAFVGVPCGImDqtaAAC 192
Cdd:TIGR00549  70 RFSELNPPPL---EITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGI-D---TAT 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 193 CTDGHALFLDtrdlaQRQVPFD-LAGEGLRLLVVDTRVKHELGDgAYAQRRAMCERGARALGVHAlrdvpyahlpEALDK 271
Cdd:TIGR00549 143 STSGGPVYFE-----KGEGEFTkLISLDGYFVIADTGVSGSTKE-AVARVRQLLERFPELIDSIM----------DAIGE 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 272 LAATDEEPgggkgdggpgtaavvrhvvtenrrveeviarLDAGEARAIGPLLTAGHASLrDDFRVSCAELDLAVEAAGAA 351
Cdd:TIGR00549 207 LTLEAKAA-------------------------------LQDGDVESLGELMNINQGLL-KALGVSHPKLDQLVEIARKA 254

                         330
                  ....*....|....*....
gi 1751532519 352 GALGARMTGGGFGGSAIVL 370
Cdd:TIGR00549 255 GALGAKLTGAGGGGCMIAL 273
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 126-192 2.12e-15

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 70.27  E-value: 2.12e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1751532519 126 DLHYESTVPVGAGLSSSAALEVATALALDDLYGLGltrqrLAQLAQRAENAFVGVPCGIMDQTAAAC 192
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFGLP-----LAKLALEAEELAGGGRGGGMDVAASLY 62
PRK03926 PRK03926
mevalonate kinase; Provisional
 121-386 6.28e-10

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 59.68  E-value: 6.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 121 PVGGADLHYESTVPVGAGLSSSAALEVATALALDDLYGLGLTRQRLAQLAQRAENAFVGVPCGImDQTAaacCTDGHALF 200
Cdd:PRK03926   72 DKDGVTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVELLVQGAASPT-DTYV---STMGGFVT 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 201 LDTRdlaqRQVPFDLAGeglrLLVVDTrvkhelgdGAYAQRRAMCERGARAlgvhalrdvpYAHLPEALDKLAATdeepg 280
Cdd:PRK03926  148 IPDR----KKLPFPECG----IVVGYT--------GSSGSTKELVANVRKL----------KEEYPELIEPILSS----- 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 281 ggkgdggpgtaavVRHVVtenRRVEEVIArldAGEARAIGPLLTAGHAsLRDDFRVSCAELDLAVEAAGAAGALGARMTG 360
Cdd:PRK03926  197 -------------IGKIS---EKGEELIL---SGDYVSLGELMNINQG-LLDALGVSTKELSELIYAARTAGALGAKITG 256

                         250       260
                  ....*....|....*....|....*.
gi 1751532519 361 GGFGGSAIVLVEETDADAVAVRITEA 386
Cdd:PRK03926  257 AGGGGCMVALAAPEKQSEVATAIKIA 282
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 112-170 8.36e-06

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 47.04  E-value: 8.36e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1751532519 112 AWALRDA-GLPvGGADLHYESTVPVGAGL---SSSAAlevATALALDDLYGLGLTRQRLAQLA 170
Cdd:COG1947    71 ARLLQEAtGIP-PGVDIHLEKRIPVGAGLgggSSDAA---ATLRALNRLWGLGLSREELAELA 129
MVD1 COG3407
Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate ...
 130-173 1.20e-05

Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate pyrophosphate decarboxylase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 442633  Cd Length: 322  Bit Score: 46.72  E-value: 1.20e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1751532519 130 ESTVPVGAGLSSSAALEVATALALDDLYGLGLTRQRLAQLAQRA 173
Cdd:COG3407    96 ENNFPTAAGLASSASGFAALALAANSAEGLDLDDRKLSRLARLG 139
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 137-386 3.68e-04

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 42.15  E-value: 3.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 137 AGLSSSAALEVATALALDDLYGLGLTRQRLAQLAQRAENAFVGVPCGImDQTAAaccTDGhALFLDTRDLAQRQVPFDLA 216
Cdd:PTZ00298  107 SGIGASASDVVSLSRALSELYQLNLTEEEVNLSAFVGEGGYHGTPSGA-DNTAA---TYG-GLISYRRVNGKSVFKRIAF 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 217 GEGLRLLVVDTRVK----------HELGDGAYAQRRAMCERgaralgvhalrdvpYAHLpealdklaatdeepgggkgdg 286
Cdd:PTZ00298  182 QQPLYLVVCSTGITasttkvvgdvRKLKENQPTWFNRLLEN--------------YNAC--------------------- 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751532519 287 gpgtaavvrhvvtenrrVEEVIARLDAGEARAIGPLLTAGHaSLRDDFRVSCAELDLAVEAAGAAGALGARMTGGGFGGS 366
Cdd:PTZ00298  227 -----------------VSEAKEALQKGNLFRVGELMNANH-DLCQKLTVSCRELDSIVQTCRTYGALGAKMSGTGRGGL 288

                         250       260
                  ....*....|....*....|....*
gi 1751532519 367 AIVLVEETD-----ADAVAVRITEA 386
Cdd:PTZ00298  289 VVALAASEDqrdaiAKAVRARCPEA 313
PRK01212 PRK01212
homoserine kinase; Provisional
 109-170 5.71e-04

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 41.67  E-value: 5.71e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1751532519 109 AGVAW-ALRDAGLPVGGADLHYESTVPVGAGLSSSAALEVATALALDDLYGLGLTRQRLAQLA 170
Cdd:PRK01212   65 VYQAAlKFLEKLGKPPGLRIELEKNIPLGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLA 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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