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Conserved domains on  [gi|1736209020|gb|QEO12454|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Bos taurus]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.20e-41

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 131.21  E-value: 2.20e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736209020  1 MSMVYMNIMMAFTVSLVGLLMYRSHLMSSLLCLEGMVLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1736209020 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.20e-41

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 131.21  E-value: 2.20e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736209020  1 MSMVYMNIMMAFTVSLVGLLMYRSHLMSSLLCLEGMVLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1736209020 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 2.28e-13

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 59.89  E-value: 2.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736209020  3 MVYMNIMMAFTVSLVGLLmYRSHLMSSLLCLEGMVLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVMVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 1736209020 83 NTYGTDYVQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 7.21e-03

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 32.73  E-value: 7.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736209020 12 FTVSLVGLLMyRSHLMSSLLCLEGMVLSlfVMAALTILNSHFTLAS--MMPIILLVFAACEAALGLSLLVMVSNTYGTDY 89
Cdd:COG0713   14 FAIGLYGVLT-RRNLIVVLMSIELMLNA--VNLNLVAFSRYLGDLDgqVFALFVIAVAAAEVAVGLAIIVALYRNRGTID 90


                 ....*..
gi 1736209020 90 VQNLNLL 96
Cdd:COG0713   91 VDDLNEL 97
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.20e-41

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 131.21  E-value: 2.20e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736209020  1 MSMVYMNIMMAFTVSLVGLLMYRSHLMSSLLCLEGMVLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1736209020 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.78e-24

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 86.94  E-value: 6.78e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736209020  1 MSMVYMNIMMAFTVSLVGLLMYRSHLMSSLLCLEGMVLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00126   1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                         90
                 ....*....|....*...
gi 1736209020 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00126  81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.01e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 85.67  E-value: 2.01e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736209020  1 MSMVYMNIMMAFTVSLVGLLMYRSHLMSSLLCLEGMVLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00125   1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                         90
                 ....*....|....*...
gi 1736209020 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00125  81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 4.23e-20

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 77.34  E-value: 4.23e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736209020  1 MSMVYMNIMMAFTVSLVGLLMYRSHLMSSLLCLEGMVLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00067   1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                         90
                 ....*....|....*...
gi 1736209020 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00067  81 TTRTHGTDHLKNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 2.28e-13

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 59.89  E-value: 2.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736209020  3 MVYMNIMMAFTVSLVGLLmYRSHLMSSLLCLEGMVLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVMVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 1736209020 83 NTYGTDYVQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 5-96 6.00e-13

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 58.80  E-value: 6.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736209020  5 YMNIMMAFTVSLVGLLMYRSHLMSSLLCLEGMVLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVMVSNT 84
Cdd:MTH00181   2 MFVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRT 81

                         90
                 ....*....|..
gi 1736209020 85 YGTDYVQNLNLL 96
Cdd:MTH00181  82 HGSDHLLKFNLL 93
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 12-97 4.20e-10

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 51.84  E-value: 4.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736209020 12 FTVSLVGLLMYRSHLMSSLLCLEGMVLSLFVMAALTILNSHFTLASMMPIILLVFAACEAALGLSLLVMVSNTYGTDYVQ 91
Cdd:MTH00043  12 FFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVLLSRNHNSDLVA 91


                 ....*.
gi 1736209020 92 NLNLLQ 97
Cdd:MTH00043  92 SLNLLQ 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.12e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 47.92  E-value: 1.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736209020  1 MSMVYMNIMMAFTVSLVGLLMYRSHLMSSLLCLEGMVLSLFVMaaLTILNSHFTLASMMPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00149   2 MFMLLLLSLFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVM--MFSSSGLISFSSYLFLIILTFGACEASLGLSLLVS 79

                         90
                 ....*....|....*...
gi 1736209020 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00149  80 LIRLHGNDYVSSLSSLKF 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 3-92 1.14e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 47.84  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736209020  3 MVYMNIMMAFTVSLVGLLMYRSHLMSSLLCLEGMVLSLFVMaaLTILNSHFTLASMMPIILLVFAACEAALGLSLLVMVS 82
Cdd:MTH00162   2 MMLLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFL--LFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMI 79

                         90
                 ....*....|
gi 1736209020 83 NTYGTDYVQN 92
Cdd:MTH00162  80 RSHGNDYFSS 89
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 8-98 5.89e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 46.12  E-value: 5.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736209020  8 IMMAFTVSLVGLLMYRSHLMSSLLCLEGMVLSLFVMAALTILNSHFTLasMMPIILLVFAACEAALGLSLLVMVSNTYGT 87
Cdd:MTH00188   9 ILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKEL--YLSLVLLTFAACEASVGLALLVSLIRSHGS 86

                         90
                 ....*....|.
gi 1736209020 88 DYVQNLNLLQC 98
Cdd:MTH00188  87 DYVSSLNLIKC 97
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 5.35e-06

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 41.28  E-value: 5.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736209020  1 MSMVYMNIMMAFTVSLVGLLMYRSHLMSSLLCLEGMVLSLFVMAALTILNSHfTLASMMPIILLVFAACEAALGLSLLVM 80
Cdd:MTH00013   1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFAN-QVNGMLAIVLLTFGACEASLGLSLLVL 79

                         90
                 ....*....|....*...
gi 1736209020 81 VSNTYGTDYVQNLNLLQC 98
Cdd:MTH00013  80 MTRSYGNDMLKSLTSNKC 97
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 7.21e-03

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 32.73  E-value: 7.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1736209020 12 FTVSLVGLLMyRSHLMSSLLCLEGMVLSlfVMAALTILNSHFTLAS--MMPIILLVFAACEAALGLSLLVMVSNTYGTDY 89
Cdd:COG0713   14 FAIGLYGVLT-RRNLIVVLMSIELMLNA--VNLNLVAFSRYLGDLDgqVFALFVIAVAAAEVAVGLAIIVALYRNRGTID 90


                 ....*..
gi 1736209020 90 VQNLNLL 96
Cdd:COG0713   91 VDDLNEL 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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