|
Name |
Accession |
Description |
Interval |
E-value |
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
16-394 |
0e+00 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 566.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 16 FRTRAIHVGNEIDPATGAVVPPIHLASTFRQPGAGEW--------GEFDYSRSGNPTRSNLQNTLASLESGVGALAFASG 87
Cdd:COG0626 3 PATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAEALaarfageeGGYIYSRYGNPTRRALEEALAALEGGEAALAFASG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 88 MAAIHCVTM-LLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDL 166
Cdd:COG0626 83 MAAISAVLLaLLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEVVDI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 167 PRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADKDLFDRLYFIQNATGAVLDPL 246
Cdd:COG0626 163 AAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAVLSPF 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 247 SCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLDgGFGAMVTFELDAGIAETAKAC 326
Cdd:COG0626 243 DAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMS-GFGGMLSFELKGGREAARRFL 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1726208097 327 ESTKLFHLAVSLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAIDAA 394
Cdd:COG0626 322 DALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALAAL 389
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
18-390 |
0e+00 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 517.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 18 TRAIHVGNEIDPATGAVVPPIHLASTFRQPGAGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIHC-VTM 96
Cdd:pfam01053 2 TLAVHAGQRPDPQTGAVSVPIYLTSTYVFDFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAITAaILA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 97 LLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDLPRLASIAKQR 176
Cdd:pfam01053 82 LLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEAIAKLAKKH 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 177 GVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADKDLFDRLYFIQNATGAVLDPLSCFLVSRGLK 256
Cdd:pfam01053 162 GILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDAWLLLRGLK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 257 TLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLDgGFGAMVTFELDAGIAETAKACESTKLFHLAV 336
Cdd:pfam01053 242 TLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMK-GFGGMLSFELKGGLEAAKKFLDNLKLFSLAV 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1726208097 337 SLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQA 390
Cdd:pfam01053 321 SLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQA 374
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
32-392 |
1.60e-173 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 488.64 E-value: 1.60e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 32 GAVVPPIHLASTFRQPGAGEW--------GEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIHCVTM-LLEQGD 102
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSPAEAadlfalreGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLaLLKAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 103 HVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDLPRLASIAKQRGVLIGV 182
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 183 DNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADKDLFDRLYFIQNATGAVLDPLSCFLVSRGLKTLDLRI 262
Cdd:cd00614 161 DNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 263 REQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLdGGFGAMVTFELDAGIAETAKACESTKLFHLAVSLGAVE 342
Cdd:cd00614 241 ERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQM-SGYGGVFSFELKGGLEAAKKFLNALKLFSLAVSLGGVE 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1726208097 343 SLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAID 392
Cdd:cd00614 320 SLVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
4-393 |
6.91e-160 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 454.49 E-value: 6.91e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 4 QDGRGEASRENAFRTRAIHVGNEIDPATGAVVPPIHLASTFRQPGAGEW-GEFDYSRSGNPTRSNLQNTLASLESGVGAL 82
Cdd:PRK07811 1 SEDMSDHHANQGFATRAIHAGYEPDPATGAVNPPIYASSTFAQDGVGGLrGGYEYARTGNPTRTALEEQLAALEGGAYGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 83 AFASGMAAIHCV-TMLLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRL 161
Cdd:PRK07811 81 AFSSGMAATDCLlRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 162 TIPDLPRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADKDLFDRLYFIQNATGA 241
Cdd:PRK07811 161 SITDIAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAFLQNGAGA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 242 VLDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLdGGFGAMVTFELDAGIAE 321
Cdd:PRK07811 241 VPGPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQM-RGFGGMVSVRLAGGEEA 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1726208097 322 TAKACESTKLFHLAVSLGAVESLIEQPATMSHASydaADRARFGITDGLIRLSVGLESPGDLREDLTQAIDA 393
Cdd:PRK07811 320 ARDFCARTKVFTLAESLGGVESLIEHPSAMTHAS---TAGSQLEVPDDLVRLSVGIEDVADLLADLEQALGQ 388
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
17-392 |
1.10e-146 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 420.67 E-value: 1.10e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 17 RTRAIHVGNEIDPATGAVVPPIHLASTFRQPGAGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIHCVTM 96
Cdd:PRK07671 4 KTKLIHGGIIGDPSTGAVSVPIYQVSTYKQEAVGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAITAVMM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 97 LLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDLPRLASIAKQR 176
Cdd:PRK07671 84 LFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTIAKEK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 177 GVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADKDLFDRLYFIQNATGAVLDPLSCFLVSRGLK 256
Cdd:PRK07671 164 GLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPELAEDLHFVQNSTGGILGPQDSWLLLRGLK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 257 TLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLDgGFGAMVTFelDAGIAETA-KACESTKLFHLA 335
Cdd:PRK07671 244 TLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQAN-GFGGMISF--DVGSEETAnKVLERLQYFTLA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1726208097 336 VSLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAID 392
Cdd:PRK07671 321 ESLGAVESLISIPSQMTHASIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
10-394 |
5.28e-145 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 418.28 E-value: 5.28e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 10 ASRENAFRTRAIHVGNEIDPATGAVVPPIHLASTF--------------RQPGagewgeFDYSRSGNPTRSNLQNTLASL 75
Cdd:COG2873 2 TEKKYGFETLALHAGQEPDPTTGARAVPIYQTTSYvfddaehaadlfalKEPG------NIYTRIMNPTTDVLEKRIAAL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 76 ESGVGALAFASGMAAIH-CVTMLLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAE 154
Cdd:COG2873 76 EGGVAALATASGQAAITlAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 155 TIGNPRLTIPDLPRLASIAKQRGV-LIgVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTL--------AVAD 225
Cdd:COG2873 156 TIGNPALDVLDIEAIAEIAHEHGVpLI-VDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIvdggnfdwAANG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 226 K-----------------DLFDRLYFIQNA-------TGAVLDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPK 281
Cdd:COG2873 235 KfpeltepdpsyhglvytEAFGNAAFITKArvqllrdLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPK 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 282 VRTVLYPGLESHPQHALAAKTLDGGFGAMVTFELDAGIAETAKACESTKLFHLAVSLGAVESLIEQPATMSHASYDAADR 361
Cdd:COG2873 315 VAWVNYPGLPSHPYHELAQKYLPKGAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQ 394
|
410 420 430
....*....|....*....|....*....|...
gi 1726208097 362 ARFGITDGLIRLSVGLESPGDLREDLTQAIDAA 394
Cdd:COG2873 395 AAAGVTPDLIRLSVGIEDIDDIIADLDQALAAA 427
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
11-392 |
2.65e-141 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 407.62 E-value: 2.65e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 11 SRENAFRTRAIHVGNEIDPATGAVVPPIHLASTFRQPGAGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAA 90
Cdd:PRK08064 2 AMSYSIDTLLLHNQYKHDKQTGAVNVPIYHASTFHQFDFDTFGKYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 91 IHCVTMLLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDLPRLA 170
Cdd:PRK08064 82 ISTAFLLLSKGDHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 171 SIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADKDLFDRLYFIQNATGAVLDPLSCFL 250
Cdd:PRK08064 162 KLAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQKLYFLQNSFGAVLGVQDCWL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 251 VSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALaAKTLDGGFGAMVTFELDAGIAeTAKACESTK 330
Cdd:PRK08064 242 VLRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTHLGFDI-QQSQATSAGAVLSFTLQSEEA-VRQFVSHVK 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1726208097 331 LFHLAVSLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAID 392
Cdd:PRK08064 320 LPVFAVSLGAVESILSYPAKMSHAAMPKEERDERGITDGLLRLSVGLENVDDLIADFEQALS 381
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
18-394 |
1.13e-129 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 377.63 E-value: 1.13e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 18 TRAIHVGNEIDPaTGAVVPPIHLASTFRQPGAGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIHCVTML 97
Cdd:TIGR01329 3 TLLVNTDNKNDP-YDASSMPIYQTATFKQPLAIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDVITRL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 98 LEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDLPRLASIAKQRG 177
Cdd:TIGR01329 82 LNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHAQN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 178 VLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADKDLFDRLYFIQNATGAVLDPLSCFLVSRGLKT 257
Cdd:TIGR01329 162 ALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEEIAKKVYFLQNSTGSGLAPFDCWLLLRGIKT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 258 LDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALaAKTLDGGFGAMVTFElDAGIAETAKACESTKLFHLAVS 337
Cdd:TIGR01329 242 LAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHL-HFSQAKGAGSVLSFE-TGSVALSKRLVEATKLFSITVS 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1726208097 338 LGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAIDAA 394
Cdd:TIGR01329 320 FGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAFVTA 376
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
16-393 |
2.73e-124 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 363.83 E-value: 2.73e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 16 FRTRAIHVGNEIDPATGAVVPPIHLASTFRQPGAGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIHCVT 95
Cdd:PRK06176 3 MQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 96 MLLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDLPRLASIAKQ 175
Cdd:PRK06176 83 SLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKD 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 176 RGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADKDLFDRLYFIQNATGAVLDPLSCFLVSRGL 255
Cdd:PRK06176 163 HGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 256 KTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLDgGFGAMVTFELdAGIAETAKACESTKLFHLA 335
Cdd:PRK06176 243 KTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMR-GFSGMLSFTL-KNDSEAVAFVESLKLFILG 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1726208097 336 VSLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAIDA 393
Cdd:PRK06176 321 ESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAK 378
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
16-391 |
5.38e-121 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 357.05 E-value: 5.38e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 16 FRTRAIHVGNEIDPATGAVVPPIHL--ASTFRQP-------GAGEWGEFdYSRSGNPTRSNLQNTLASLESGVGALAFAS 86
Cdd:TIGR01326 2 FETLQLHAGQEPDPTTGSRAVPIYQttSYVFDSTehaaalfGLQEPGNI-YSRLMNPTTDVLEQRIAALEGGVAALAVAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 87 GMAAI-HCVTMLLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPD 165
Cdd:TIGR01326 81 GQAAItYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINVLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 166 LPRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADK------------------- 226
Cdd:TIGR01326 161 IEAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVDGGKfdwnngrfplfttpdpsyh 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 227 -----DLFDRLYFIQNA-------TGAVLDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHP 294
Cdd:TIGR01326 241 glvftETLGNPAFILKArvqllrdLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLASHP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 295 QHALAAKTLDGGFGAMVTFELDAGIAETAKACESTKLFHLAVSLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLS 374
Cdd:TIGR01326 321 HHALAKKYLPKGFGAVLSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLIRLS 400
|
410
....*....|....*..
gi 1726208097 375 VGLESPGDLREDLTQAI 391
Cdd:TIGR01326 401 VGIENIDDIIADLEQAL 417
|
|
| O_succ_thio_ly |
TIGR02080 |
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ... |
18-394 |
1.60e-120 |
|
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 131135 Cd Length: 382 Bit Score: 354.49 E-value: 1.60e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 18 TRAIHVGNEIDPATGAVVPPIHLASTFRQPGAGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIHCVTM- 96
Cdd:TIGR02080 6 TIAVRSGLNSDTQYGCVVPPIYLSTTYNFTGFNEPRAYDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAIHLVTTa 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 97 LLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDLPRLASIAKQR 176
Cdd:TIGR02080 86 LLGPDDLLVAPHDCYGGTYRLLNALAKKGCFRVLFVDQGDEQALRAALAQKPKLVLIETPSNPLLRVVDIAKICHLAKAV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 177 GVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADKDLFDRLYFIQNATGAVLDPLSCFLVSRGLK 256
Cdd:TIGR02080 166 GAVVVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVIAGAVIAKDPQVAEELAWWANNLGVTGGAFDSYLTLRGLR 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 257 TLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTlDGGFGAMVTFELDAGIAETAKACESTKLFHLAV 336
Cdd:TIGR02080 246 TLVARMRLQQRNAQAIVEYLQTQPLVKKIYYPGLPDHPGHEIAARQ-QKGFGAMLSFELKGGEQTVRRFLGGLSLFTLAE 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1726208097 337 SLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAIDAA 394
Cdd:TIGR02080 325 SLGGVESLIAHPATMTHAAMGPEARAEAGISDTLLRLSVGLEDADDLIADLEQGLRAA 382
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
16-392 |
3.97e-120 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 354.13 E-value: 3.97e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 16 FRTRAIHVGNEIDPATGAVVPPIHLASTF-----RQPG---AGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASG 87
Cdd:PRK06234 9 FATKAIHGGHIGDKQFGSLATPIYQTSTFifdsaEQGGrrfAGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAASG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 88 MAAI-HCVTMLLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDL 166
Cdd:PRK06234 89 MGAIsSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANPTLKVTDI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 167 PRLASIA--KQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGtLAVADKDLFD--RLYFIQNATGAV 242
Cdd:PRK06234 169 KAISNIAheNNKECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAG-FVVGKEEFINqvKLFGIKDMTGSV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 243 LDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLDGgFGAMVTFELDAGIAET 322
Cdd:PRK06234 248 IGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSL-PGAMISFELKGGVEEG 326
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 323 AKACESTKLFHLAVSLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAID 392
Cdd:PRK06234 327 KVVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQALD 396
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
13-391 |
1.30e-119 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 351.31 E-value: 1.30e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 13 ENAFRTRAIHVGNEIDPATGAVVPPIHLASTFRQPGAGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIH 92
Cdd:PRK08247 2 MSTIETKLAQIGNRSDERTGTVNPPVYFSTAYRHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 93 CVTMLLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDLPRLASI 172
Cdd:PRK08247 82 LVMSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 173 AKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADKDLFDRLYFIQNATGAVLDPLSCFLVS 252
Cdd:PRK08247 162 AKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERLAYYQNAAGAVLSPFDSWLLI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 253 RGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLeshpqhalaaktldggfGAMVTFEL--DAGIAETAKaceSTK 330
Cdd:PRK08247 242 RGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYPGR-----------------GGMLSFRLqdEEWVNPFLK---SLK 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1726208097 331 LFHLAVSLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAI 391
Cdd:PRK08247 302 LITFAESLGGVESFITYPATQTHADIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAF 362
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
9-391 |
3.22e-119 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 353.95 E-value: 3.22e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 9 EASRENAFRTRAIHVGNEIDPATgAVVPPIHLASTFRQPGAGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGM 88
Cdd:PLN02509 80 NIKEEASVSTLLVNLDNKFDPFD-AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGM 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 89 AAIHCVTMLLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDLPR 168
Cdd:PLN02509 159 AALSAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRK 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 169 LASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADKDLFDRLYFIQNATGAVLDPLSC 248
Cdd:PLN02509 239 IAEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDC 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 249 FLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLDGGfGAMVTFeLDAGIAETAKACES 328
Cdd:PLN02509 319 WLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGA-GSVFSF-ITGSVALSKHLVET 396
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1726208097 329 TKLFHLAVSLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAI 391
Cdd:PLN02509 397 TKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 459
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
16-393 |
5.83e-119 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 350.73 E-value: 5.83e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 16 FRTRAIHVGNEIDPATGAVVPPIHLASTF-----RQPG---AGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASG 87
Cdd:TIGR01328 4 FATRAIHAGYPPKDQFGALTPPIYQTSTFvfdscEQGGnrfAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVATSSG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 88 MAAIHCVTM-LLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDL 166
Cdd:TIGR01328 84 MGAIAATLLtILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKLIDM 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 167 PRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGtLAVADKDLFD--RLYFIQNATGAVLD 244
Cdd:TIGR01328 164 ERVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAG-LICGKAELLQqiRMVGIKDMTGSVIS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 245 PLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLDGGfGAMVTFELDAGIAETAK 324
Cdd:TIGR01328 243 PFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRMG-GGMITFELKGGFAGAKK 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1726208097 325 ACESTKLFHLAVSLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAIDA 393
Cdd:TIGR01328 322 LLNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGLEDADDLIADLKQALDA 390
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
16-394 |
1.65e-117 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 347.56 E-value: 1.65e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 16 FRTRAIHVGneIDPAT--GAVVPPIHLASTFRQPG--------AGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFA 85
Cdd:PRK07503 10 FSTRAIHHG--YDPLDhgGALVPPVYLTATFAFPTaeygaecfAGEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 86 SGMAAIHCVT-MLLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIP 164
Cdd:PRK07503 88 SGMGAITATLwTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 165 DLPRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGtLAVADKDLFD--RLYFIQNATGAV 242
Cdd:PRK07503 168 DIAAVAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAG-LVVGGKALADriRLEGLKDMTGAV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 243 LDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLdGGFGAMVTFELDAGIAET 322
Cdd:PRK07503 247 MSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQM-ALPGGMIAFELKGGIAAG 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1726208097 323 AKACESTKLFHLAVSLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAIDAA 394
Cdd:PRK07503 326 RRFMNALQLFARAVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALDAC 397
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
15-393 |
4.23e-113 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 335.82 E-value: 4.23e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 15 AFRTRAIHVGNEIDPAtGAVVPPIHLASTFR-----QPGAGEWGEFD---YSRSGNPTRSNLQNTLASLESGVGALAFAS 86
Cdd:PRK08133 6 GFDTLAVRAGQLRSPF-GEHSEALFLTSSFVfesaaEAAARFAGEEPgniYSRFTNPTVTMFQERLAALEGAEACVATAS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 87 GMAAIHCVTM-LLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPD 165
Cdd:PRK08133 85 GMAAILAVVMaLLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLTELAD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 166 LPRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLaVADKDLFDRLY-FIQNAtGAVLD 244
Cdd:PRK08133 165 IAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAV-VGSKELMEEVFgFLRTA-GPTLS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 245 PLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTlDGGFGAMVTFELDAGIAETAK 324
Cdd:PRK08133 243 PFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQ-QKGGGAIVSFEVKGGREAAWR 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1726208097 325 ACESTKLFHLAVSLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAIDA 393
Cdd:PRK08133 322 VIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLARGLAA 390
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
18-393 |
1.63e-112 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 333.96 E-value: 1.63e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 18 TRAIHVGNEIDPaTGAVVPPIHLASTFRQPGAGEWGE--FD--YSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIHC 93
Cdd:PRK08574 5 TDAVRGYRGSDP-YGSLQPPIYLTALFRQEGEAYPSDrgFDlkYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAIST 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 94 VTM-LLEQGDHVVAGCDLYGGAYRLLHKIcNRSGIDVTLVdMTDADAVSDAVND-RTKLIWAETIGNPRLTIPDLPRLAS 171
Cdd:PRK08574 84 LFFsLLKAGDRVVLPMEAYGTTLRLLKSL-EKFGVKVVLA-YPSTEDIIEAIKEgRTKLVFIETMTNPTLKVIDVPEVAK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 172 IAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADKDLFDRLYFIQNATGAVLDPLSCFLV 251
Cdd:PRK08574 162 AAKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEELWEWRRRLGTIMQPFEAYLV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 252 SRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLDGG-FGAMVTFELDAGIAETAKACESTK 330
Cdd:PRK08574 242 LRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRLFGKDlYGGVVSFRVKGGRDAVLKFLRSLK 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1726208097 331 LFHLAVSLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAIDA 393
Cdd:PRK08574 322 LIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQALGS 384
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
15-394 |
2.04e-111 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 331.71 E-value: 2.04e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 15 AFRTRAIHVGNEIDPATGAVVPPIHLASTFRQPGAGEWGE--------FDYSRSGNPTRSNLQNTLASLESGVGALAFAS 86
Cdd:PRK08249 8 GVGTKAVWAGEKEYLPYGATQVPVVLSVAYGYDDIDEWYDvalgkkpgHIYSRNTNPTVQAFEEKVRILEGAEAATAFST 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 87 GMAAIHCVTM-LLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPD 165
Cdd:PRK08249 88 GMAAISNTLYtFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLKIVD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 166 LPRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGtLAVADKDLFDRLYFIQNATGAVLDP 245
Cdd:PRK08249 168 IERLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGG-VVCGSKELMEQVYHYREINGATMDP 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 246 LSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLDgGFGAMVTFELDAGIAETAKA 325
Cdd:PRK08249 247 MSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQMR-GFGGILSFVLKGGMDTVKRL 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1726208097 326 CESTKLFHLAVSLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAIDAA 394
Cdd:PRK08249 326 LPKLRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEGLVRISVGIEDTEDLIADLEQAFAHL 394
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
18-394 |
5.95e-111 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 330.80 E-value: 5.95e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 18 TRAIHVGNEIDPATGAVVPPIHLASTFRQPGAGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIHCV-TM 96
Cdd:PRK08776 15 TAAVRAGIDRDTAYGAVTPPIVLSSNFSFDGFGNKRQYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLVlNA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 97 LLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDLPRLASIAKQR 176
Cdd:PRK08776 95 LLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPLLRITDLRFVIEAAHKV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 177 GVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADKDLFDRLYFIQNATGAVLDPLSCFLVSRGLK 256
Cdd:PRK08776 175 GALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVWWANALGLTGSPFDAFLTLRGLR 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 257 TLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTlDGGFGAMVTFELDAGIAETAKACESTKLFHLAV 336
Cdd:PRK08776 255 TLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQ-QKGFGAMLSFELEGGEAAVRAFVDGLRYFTLAE 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1726208097 337 SLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAIDAA 394
Cdd:PRK08776 334 SLGGVESLIAHPASMTHAAMTAEARAAAGISDGLLRLSVGIESAEDLLIDLRAGLARA 391
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
18-395 |
8.53e-102 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 306.82 E-value: 8.53e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 18 TRAIHVGNEIDPATGAVVPPIHLASTFRQPGAGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIHCVTML 97
Cdd:PRK08045 7 TIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 98 -LEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDLPRLASIAKQR 176
Cdd:PRK08045 87 fLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 177 GVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADKDLFDRLYFIQNATGAVLDPLSCFLVSRGLK 256
Cdd:PRK08045 167 GAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 257 TLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTlDGGFGAMVTFELDAGIAETAKACESTKLFHLAV 336
Cdd:PRK08045 247 TLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQ-QKGFGAMLSFELDGDEQTLRRFLGGLSLFTLAE 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1726208097 337 SLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAIDAAL 395
Cdd:PRK08045 326 SLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAAN 384
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
3-394 |
2.33e-100 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 304.75 E-value: 2.33e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 3 DQDGRGEASRENAFRTRAIHVGNEIDPATGAVVPPI------------HLASTFrqpGAGEWGEFdYSRSGNPTRSNLQN 70
Cdd:PRK07812 1 STSTDADPTANWSFETKQIHAGQTPDPATNARALPIyqttsytfddtdHAAALF---GLAEPGNI-YTRIMNPTQDVVEQ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 71 TLASLESGVGALAFASGMAA-IHCVTMLLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLV-DMTDADAVSDAVNDRT 148
Cdd:PRK07812 77 RIAALEGGVAALLLASGQAAeTFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVeDPDDLDAWRAAVRPNT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 149 KLIWAETIGNPRLTIPDLPRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGtlAVADKDL 228
Cdd:PRK07812 157 KAFFAETISNPQIDVLDIPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAG--VIVDGGT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 229 FD---------------------------------RLYFIQNaTGAVLDPLSCFLVSRGLKTLDLRIREQSKTALELSRW 275
Cdd:PRK07812 235 FDwtqgrfpgfttpdpsyhgvvfaelgppayalkaRVQLLRD-LGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEF 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 276 LEQHPKVRTVLYPGLESHPQHALAAKTLDGGFGAMVTFELDAGIAETAKACESTKLFHLAVSLGAVESLIEQPATMSHAS 355
Cdd:PRK07812 314 LEARDEVASVNYAGLPSSPWYERAKRLAPKGTGAVLSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQ 393
|
410 420 430
....*....|....*....|....*....|....*....
gi 1726208097 356 YDAADRARFGITDGLIRLSVGLESPGDLREDLTQAIDAA 394
Cdd:PRK07812 394 LTPEEQLATGVTPGLVRLAVGIEGIDDILADLEAGFAAA 432
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
18-391 |
1.02e-99 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 300.98 E-value: 1.02e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 18 TRAIHVGneIDPATGAVVPPIHLASTFRQPGaGEwgEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIHCVTM- 96
Cdd:PRK06460 5 TRTVRED--IDEATGAITTPIYQTTAYHYPE-GE--KYRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTALa 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 97 LLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDLPRLASIAKQR 176
Cdd:PRK06460 80 LLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKEN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 177 GVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGtLAVADKDLFDRLYFIQNATGAVLDPLSCFLVSRGLK 256
Cdd:PRK06460 160 GSILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAG-LAAGYGKLLNVIDQMRRTLGTSLDPHAAYLTLRGIK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 257 TLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLDgGFGAMVTFELDAGIAETAKACESTKLFHLAV 336
Cdd:PRK06460 239 TLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLK-GFGGVLSFEVNGGQESALKVMKSLKLIIPAQ 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1726208097 337 SLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAI 391
Cdd:PRK06460 318 TLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRAL 372
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
12-392 |
1.56e-99 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 300.99 E-value: 1.56e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 12 RENAFRTRAIHVGNEIDPATGAVVPPIHLASTF-----RQPG---AGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALA 83
Cdd:PRK06767 2 KKKHMETALIHHGYTSEEHKGSLTPPLFQTSTFtfetaQQGEasfAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 84 FASGMAAIHCVTM-LLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLT 162
Cdd:PRK06767 82 FGSGMAAISATLIgFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 163 IPDLPRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGtLAVADKDLFDRLYF-IQNATGA 241
Cdd:PRK06767 162 LIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAG-VTICKTRALAEKIRpMRKDIGG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 242 VLDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYpgleshPQHALAAKTLDGGfGAMVTFELDAGIAE 321
Cdd:PRK06767 241 IMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWY------PEGELASRQMKRG-GGVISFSIKGGKEE 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1726208097 322 TAKACESTKLFHLAVSLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAID 392
Cdd:PRK06767 314 TQAFINDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALK 384
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
10-394 |
4.35e-99 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 301.27 E-value: 4.35e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 10 ASRENAFRTRAIHVGNEIDPATGAVVPPIHLASTFRQPGAG--------EWGEFDYSRSGNPTRSNLQNTLASLESGVGA 81
Cdd:PRK08134 3 GMSPPGFDTLALHAGAAPDPATGARAVPIHLTTSFVFRDSDhaaalfnlERAGHVYSRISNPTVAVLEERVAALEGGVGA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 82 LAFASGMAAIH-CVTMLLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPR 160
Cdd:PRK08134 83 IATASGQAALHlAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 161 LTIPDLPRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGtlAVADKDLFD---------- 230
Cdd:PRK08134 163 LEVLDIPTVAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGG--VLVDGGRFDweasgkfpel 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 231 --------RLYFIQNAT----------------GAVLDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVL 286
Cdd:PRK08134 241 tepyagfhGMVFAEESTvaafllrarreglrdfGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 287 YPGLESHPQHALAAKTLDGGFGAMVTFELDAGIAETAKACESTKLF-HLAvSLGAVESLIEQPATMSHASYDAADRARFG 365
Cdd:PRK08134 321 HPELESHPDHALAKRLLPRGAGSVFSFDLKGGRAAGRKFIESLKLFsHLA-NVGDARSLVIHPASTTHFRMDAAALAAAG 399
|
410 420
....*....|....*....|....*....
gi 1726208097 366 ITDGLIRLSVGLESPGDLREDLTQAIDAA 394
Cdd:PRK08134 400 IGEGTIRLSIGLEDADDLIDDLKRALKAA 428
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
18-395 |
5.03e-99 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 299.89 E-value: 5.03e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 18 TRAIHVGNEIDPATGAVVPPIHLASTFRQPGAGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIHC-VTM 96
Cdd:PRK08861 8 TIAVRTGIESDSQYHAVVPPIYLSTNYGFPAFGEVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALNLwVSA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 97 LLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDLPRLASIAKQR 176
Cdd:PRK08861 88 LLGPDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDIAELCQKAKAV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 177 GVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADKDLFDRLYFIQNATGAVLDPLSCFLVSRGLK 256
Cdd:PRK08861 168 GALVAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNCIGATGTPFDSYMTLRGIR 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 257 TLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTlDGGFGAMVTFELDAGIAETAKACESTKLFHLAV 336
Cdd:PRK08861 248 TLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQ-QSGFGSMLSFEFAGSFEQLKVFVKALALFSLAE 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1726208097 337 SLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAIDAAL 395
Cdd:PRK08861 327 SLGGVESLICHPASMTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQAFAKAA 385
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
11-394 |
1.69e-98 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 299.84 E-value: 1.69e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 11 SRENAFR--TRAIHVGNEIDPATGAVVPPIHLAST--FRQP-------GAGEWGEFdYSRSGNPTRSNLQNTLASLESGV 79
Cdd:PRK08248 2 SEERTFRleTLAIHAGQEIDPTTGSRAVPIYQTTSygFRDSehaanlfSLKEFGNI-YTRIMNPTTDVFEKRIAALEGGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 80 GALAFASGMAAI-HCVTMLLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGN 158
Cdd:PRK08248 81 GALAVSSGQAAItYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 159 PRLTIPDLPRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTL--------AVADK---- 226
Cdd:PRK08248 161 PKGDVLDIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIvdsgkfdwKGSGKfpgl 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 227 -------------DLFDRLYFIQNA-------TGAVLDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVL 286
Cdd:PRK08248 241 tepdpsyhglvytDAVGEAAYITKArvqllrdLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVS 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 287 YPGLESHPQHALAAKTLDGGFGAMVTFELDAGIAETAKACESTKLF-HLAvSLGAVESLIEQPATMSHASYDAADRARFG 365
Cdd:PRK08248 321 YPGLPSHPSYELAKKYLPKGQGAILTFGIKGGVEAGKKLIDSVKLFsHLA-NVGDSKSLIIHPASTTHQQLSEEEQLAAG 399
|
410 420
....*....|....*....|....*....
gi 1726208097 366 ITDGLIRLSVGLESPGDLREDLTQAIDAA 394
Cdd:PRK08248 400 VTPGLVRLSVGTEAIDDILDDLRQAIRQS 428
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
22-393 |
6.23e-96 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 290.95 E-value: 6.23e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 22 HVGNEIDPATGAVVPPIHLASTFRQPGAGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIHCVTMLLEQG 101
Cdd:PRK07269 13 QAGIKSDEATGALVTPLHFSTTYQHPEFGQSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAIVLAFSVFPVG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 102 DHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDmTDADAVsDAVNDRTKLIWAETIGNPRLTIPDLPRLASIAKQRGVLIG 181
Cdd:PRK07269 93 SKVVAVRDLYGGSFRWFNQQEKEGRFHFTYAN-TEEELI-AAIEEDTDIVYIETPTNPLMVEFDIEKVAKLAHAKGAKVI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 182 VDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADKDLFDRLYFIQNATGAVLDPLSCFLVSRGLKTLDLR 261
Cdd:PRK07269 171 VDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYEKLFYNLNTTGAVLSPFDSYLLMRGLKTLSLR 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 262 IREQSKTALELSRWLEQHPKVRTVLYPGLeshpqhalaaktldggfGAMVTFELdAGIAETAKACESTKLFHLAVSLGAV 341
Cdd:PRK07269 251 MERSTANAQEVVAFLKKSPAVKEVLYTGK-----------------GGMISFKV-ADETRIPHILNSLKVFTFAESLGGV 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1726208097 342 ESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAIDA 393
Cdd:PRK07269 313 ESLITYPTTQTHADIPAEVRHSYGLTDDLLRLSIGIEDARDLIADLKQALEG 364
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
49-391 |
9.57e-95 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 288.67 E-value: 9.57e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 49 AGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIHCVTM-LLEQGDHVVAGCDLYGGAYRLLHKICNRSGI 127
Cdd:TIGR01325 40 AGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGMAAIFAALMaLLGAGDHVVASRSLFGSCFVVCSEILPRFGV 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 128 DVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDLPRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSAT 207
Cdd:TIGR01325 120 QTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVDIAAVAELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSAT 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 208 KYLGGHSDCLGGTLAVADKDLFDRLYFIQNATGAVLDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLY 287
Cdd:TIGR01325 200 KHIDGQGRVLGGAILGSEEYMDEPVQKLLRHTGPAMSPFNAWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYY 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 288 PGLESHPQHALAAKTLDGGfGAMVTFELDaGIAETAKACESTKLFHLAVSLGAVESLIEQPATMSHASYDAADRARFGIT 367
Cdd:TIGR01325 280 PGLPSHPQHELAKRQMSGG-GTVVTFDLD-CRQAAFKVLDAMRLVDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIG 357
|
330 340
....*....|....*....|....
gi 1726208097 368 DGLIRLSVGLESPGDLREDLTQAI 391
Cdd:TIGR01325 358 DGLVRLSVGLEDVDDLIADIDRAL 381
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
32-394 |
4.46e-90 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 276.95 E-value: 4.46e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 32 GAVVPPIHLASTFRQPGA--------GEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIHCVTM-LLEQGD 102
Cdd:PRK05939 8 GAVHKPIHTSVTYGYEDArdlidvfqGKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLtLLRAGD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 103 HVVAGCDLYGGAYRLLHKICNRsGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDLPRLASIAKQRGVLIGV 182
Cdd:PRK05939 88 HLVSSQFLFGNTNSLFGTLRGL-GVEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYVV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 183 DNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGtlAVADKDLFD-----------RLYFIQN------------AT 239
Cdd:PRK05939 167 DNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGG--AVTDTGLFDwsaypnifpayRKGDPQQwgltqirkkglrDM 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 240 GAVLDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALaAKTLDGGFGAMVTFELDAGI 319
Cdd:PRK05939 245 GATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHAR-ATELFRHYGGLLSFELADGI 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1726208097 320 aETAKACESTKLFHLAVSLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAIDAA 394
Cdd:PRK05939 324 -DCFDFLNRLKLVIKATHLGDTRTLVIPVAPTIYYEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQALDAT 397
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
10-394 |
1.45e-88 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 274.28 E-value: 1.45e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 10 ASRENAFRTRAIHVGNEIDPATGAVVPPI------------HLASTFrqpGAGEWGEFdYSRSGNPTRSNLQNTLASLES 77
Cdd:PRK05994 2 TDRSPGFATLAVHAGAQPDPTTGARATPIyqttsfvfndadHAASLF---GLQAFGNI-YTRITNPTNAVLEERVAALEG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 78 GVGALAFASGMAAIHCV-TMLLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETI 156
Cdd:PRK05994 78 GTAALAVASGHAAQFLVfHTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 157 GNPRLTIPDLPRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADK---------- 226
Cdd:PRK05994 158 ANPGGTVTDIAAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVDGGTfdwsksgkyp 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 227 ---------------DLFDRLYFIQNAT-------GAVLDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRT 284
Cdd:PRK05994 238 mlseprpeyhglvlhETFGNFAFAIAARvlglrdlGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSW 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 285 VLYPGLESHPQHALAAKTLDGGFGAMVTFELDAGIAETAKACESTKLF-HLAvSLGAVESLIEQPATMSHASYDAADRAR 363
Cdd:PRK05994 318 VNYAGLPDDPYHALAQKYSPKGAGAVFTFGLKGGYEAGVKLVSSLKLFsHLA-NIGDTRSLVIHPASTTHRQLTDEQKVA 396
|
410 420 430
....*....|....*....|....*....|.
gi 1726208097 364 FGITDGLIRLSVGLESPGDLREDLTQAIDAA 394
Cdd:PRK05994 397 AGAGPDVVRLSIGIEDVDDIIADLEQALAKA 427
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
9-393 |
4.99e-87 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 269.08 E-value: 4.99e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 9 EASRENAFRTRAIHVGNEIDPATGAVVPPIHLASTFRQPGAGEWGEFD--------YSRSGNPTRSNLQNTLASLESGVG 80
Cdd:PRK06434 2 EKRMLNGFNTRAVQSGELRDPRFGNVTTPIFETSTFVYPNSEKEAYMDstrgmpyiYTRWGNPTVQAFEEKYAVLENAEH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 81 ALAFASGMAAI-HCVTMLLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVtlvDMTDADAVSDAVNDRTK--LIWAETIG 157
Cdd:PRK06434 82 ALSFSSGMGAItSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHV---DYIDTDRLNSLDFDPSNydLIYAESIT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 158 NPRLTIPDLPRLASIAKQRGVLigVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADKDLFDRLYFIQN 237
Cdd:PRK06434 159 NPTLKVPDIKNVSSFCHENDVI--VDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 238 ATGAVLDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLEshpqhaLAAKTLDgGFGAMVTFELDA 317
Cdd:PRK06434 237 TLGSNPDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDTE------IGKKVLR-GFGGMLSFELRS 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1726208097 318 gIAETAKACESTKLFHLAVSLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAIDA 393
Cdd:PRK06434 310 -MEDVHKFIRNLEIPMVAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENALSK 384
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
18-394 |
6.76e-87 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 269.85 E-value: 6.76e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 18 TRAIHVGNEIDPATGAVVPPIHLASTF----RQPGAGEwgeFD-------YSRSGNPTRSNLQNTLASLESGVGALAFAS 86
Cdd:PRK06084 5 TLAIHAGYSPDPTTKAVAVPIYQTTSYafddTQHGADL---FDlkvpgniYTRIMNPTNDVLEQRVAALEGGVGALAVAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 87 GMAAIHC-VTMLLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPD 165
Cdd:PRK06084 82 GMAAITYaIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIID 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 166 LPRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADK------------------- 226
Cdd:PRK06084 162 IQALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKfpwaehkerfallntpdps 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 227 -------DLFDRLYFIQN-------ATGAVLDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLES 292
Cdd:PRK06084 242 yhgvtytEAFGPAAFIGRcrvvplrNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPD 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 293 HPQHALAAKTLDGGFGAMVTFELDAGIAETAKACESTKLFHLAVSLGAVESLIEQPATMSHASYDAADRARFGITDGLIR 372
Cdd:PRK06084 322 HPEHELARRYMGGKPASILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMVR 401
|
410 420
....*....|....*....|..
gi 1726208097 373 LSVGLESPGDLREDLTQAIDAA 394
Cdd:PRK06084 402 LSIGIEHIDDIIADLAQALDAS 423
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
10-395 |
1.08e-83 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 260.40 E-value: 1.08e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 10 ASRENAFRTRAIHVGNEIDP-ATGAVVPPIHLASTFRQPG--------AGEWGEFDYSRSGNPTRSNLQNTLASLESGVG 80
Cdd:PRK05968 1 MNDGLDPFDLAALITAHDEGnAFDAVVPPIFQTSLFTFDSydemedvyAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAED 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 81 ALAFASGMAAIHC-VTMLLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDrTKLIWAETIGNP 159
Cdd:PRK05968 81 ARGFASGMAAISStVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKALPG-AKLLYLESPTSW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 160 RLTIPDLPRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGtLAVADKDLFDRLyfiqNA- 238
Cdd:PRK05968 160 VFELQDVAALAALAKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAG-VVAGSKEHIARI----NAe 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 239 ----TGAVLDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAaktldgGFGAMVTFE 314
Cdd:PRK05968 235 aypyLGAKLSPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHPPAGLS------GTSGLFSFI 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 315 LDAGIaETAKACESTKLFHLAVSLGAVESLI-------EQPATMSHAsydaadrARFGITDGLIRLSVGLESPGDLREDL 387
Cdd:PRK05968 309 FREGI-DVRAFADALKLFRLGVSWGGHESLVvpaevvlQQKAQPNSA-------ARFGVSPRSVRLHVGLEGTEALWADL 380
|
....*...
gi 1726208097 388 TQAIDAAL 395
Cdd:PRK05968 381 EQALAAAS 388
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
49-391 |
1.32e-79 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 250.42 E-value: 1.32e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 49 AGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIH-CVTMLLEQGDHVVAGCDLYGGAYRLLHKICNRSGI 127
Cdd:PRK07810 56 TGELDRFVYSRYGNPTVSMFEERLRLIEGAEACFATASGMSAVFtALGALLGAGDRLVAARSLFGSCFVVCNEILPRWGV 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 128 DVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDLPRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSAT 207
Cdd:PRK07810 136 ETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQSLVDIAAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGT 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 208 KYLGGHSDCLGGTLaVADKDLFD-RLYFIQNATGAVLDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVL 286
Cdd:PRK07810 216 KHIDGQGRVLGGAI-LGDREYIDgPVQKLMRHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVR 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 287 YPGLESHPQHALAAKTLDGGfGAMVTFELDAGiAETAKA-----CESTKLFHLAVSLGAVESLIEQPATMSHASYDAADR 361
Cdd:PRK07810 295 YPFLPSHPQYDLAKRQMSGG-GTVVTFELDAP-EDAAKKrafevLDKLRVIDISNNLGDAKSLITHPATTTHRAMGPEGR 372
|
330 340 350
....*....|....*....|....*....|
gi 1726208097 362 ARFGITDGLIRLSVGLESPGDLREDLTQAI 391
Cdd:PRK07810 373 AAIGLGDGVVRLSVGLEDTDDLIADLDRAL 402
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
50-394 |
1.48e-78 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 247.36 E-value: 1.48e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 50 GEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIHCVTML-LEQGDHVVAGCDLYGGAYRLLHKICNRSGID 128
Cdd:PRK07504 52 GEDPGFIYSRYSNPTVDMFEKRMCALEGAEDARATASGMAAVTAAILCqVKAGDHVVAARALFGSCRYVVETLLPRYGIE 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 129 VTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDLPRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATK 208
Cdd:PRK07504 132 STLVDGLDLDNWEKAVRPNTKVFFLESPTNPTLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATK 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 209 YLGGHSDCLGGTLaVADKDLFD---RLYFIQnaTGAVLDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTV 285
Cdd:PRK07504 212 HIDGQGRCLGGVV-LSDKAWIEehlQDYFRH--TGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARV 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 286 LYPGLESHPQHALAAKTLDGGfGAMVTFELDAGIAETAKACESTKLFHLAVSLGAVESLIEQPATMSHASYDAADRARFG 365
Cdd:PRK07504 289 IYPGRADHPQADIIAKQMTGG-STLVAFELKGGKEAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPEARAELG 367
|
330 340
....*....|....*....|....*....
gi 1726208097 366 ITDGLIRLSVGLESPGDLREDLTQAIDAA 394
Cdd:PRK07504 368 ISEGFLRLSAGLEDTDDLIEDLAAALKKV 396
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
28-394 |
9.59e-78 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 246.51 E-value: 9.59e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 28 DPA--TGAVVPPIHLASTF------------------RQPGAGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASG 87
Cdd:PRK07049 28 DPElsEGAVKPPVFLTSTFvfrsaedgrdffdyvsgrKEPPAGEGAGLVYSRFNHPNSEIVEDRLAVYEGAESAALFSSG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 88 MAAIhCVTML--LEQGDHVVAGCDLYGGAYRLLHKICNRSGID-VTLVDMTDADAVSDAVND-----RTKLIWAETIGNP 159
Cdd:PRK07049 108 MSAI-ATTLLafVRPGDVILHSQPLYGGTETLLAKTFRNFGVGaVGFADGLSEAAIGAAAEAaaakgRVSLILIETPANP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 160 RLTIPDLPRLASIAKQRGV------LIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTlAVADKDLFDRLY 233
Cdd:PRK07049 187 TNSLVDVAAVRRVADAIEArqghrpIIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAGA-VLGRKALIRQVR 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 234 FIQNATGAVLDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPG-LESHPQHALAAKTLDGGFGAMVT 312
Cdd:PRK07049 266 ALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPfLDPDSAYGAVYKRQCTGAGSTFS 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 313 FELDAGIAETAKACESTKLFHLAVSLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAID 392
Cdd:PRK07049 346 FDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLESTIRLSIGIEHPDDLIADLAQALD 425
|
..
gi 1726208097 393 AA 394
Cdd:PRK07049 426 AA 427
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
18-394 |
1.53e-76 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 241.44 E-value: 1.53e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 18 TRAIHVGNEiDPATGA-VVPPIHLASTFRQPGAGEWGEFDYSRSGNPTRSNLQNTLASLEsGVGALAFASGMAAIHCVTM 96
Cdd:PRK07582 6 TRSVHAGGP-EAVPGEpVLPGPVFAAPYHLSPGEPTGPDTYGRASNPTWRALEAALGELE-GAEALVFPSGMAAITAVLR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 97 -LLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDmTDADAVSDAvnDRTKLIWAETIGNPRLTIPDLPRLASIAKQ 175
Cdd:PRK07582 84 aLLRPGDTVVVPADGYYQVRALAREYLAPLGVTVREAP-TAGMAEAAL--AGADLVLAETPSNPGLDVCDLAALAAAAHA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 176 RGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADKDLFDRLYFIQNATGAVLDPLSCFLVSRGL 255
Cdd:PRK07582 161 AGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPELMAAVERWRLLAGAIPGPFEAWLAHRSL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 256 KTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLDgGFGAMVTFELdAGIAETAKACESTKLFHLA 335
Cdd:PRK07582 241 GTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMR-RFGGLVSFEL-ADAAAAERFVAASRLVVAA 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1726208097 336 VSLGAVESLIEQpatmshasydaadRARFG--ITDGLIRLSVGLESPGDLREDLTQAIDAA 394
Cdd:PRK07582 319 TSFGGVHTSADR-------------RARWGdaVPEGFVRLSCGIEDTDDLVADLERALDAL 366
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
16-393 |
3.18e-76 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 242.85 E-value: 3.18e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 16 FRTRAIHVGNEIDPATGAVVPPIHLASTF----RQPGAGEWGEFD----YSRSGNPTRSNLQNTLASLESGVGALAFASG 87
Cdd:PRK05613 14 FETRSIHAGQSVDSDTSARNLPIYQTTSYvfdsAEHAKQRFALEDlgpiYSRLTNPTVEALENRIASLEGGVHAVAFASG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 88 MAAIHCVTM-LLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLV-DMTDADAVSDAVNDRTKLIWAETIGNPRLTIPD 165
Cdd:PRK05613 94 QAAETAAILnLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVeNPDDPESWQAAVQPNTKAFFGETFANPQADVLD 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 166 LPRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLavADKDLFDRL----------YFI 235
Cdd:PRK05613 174 IPAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVL--IDGGKFDWTverdgkpvfpYFV 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 236 Q---------------------------NATGAVLDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYP 288
Cdd:PRK05613 252 TpdpayhglkyadlgapafglkaragllRDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFA 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 289 GLESHPQHALAAKTLDGGFGAMVTFELDAGIAETAKACESTKLFHLAVSLGAVESLIEQPATMSHASYDAADRARFGITD 368
Cdd:PRK05613 332 GLKDSPWYATKEKLGLKYTGSVLSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAGITQ 411
|
410 420
....*....|....*....|....*
gi 1726208097 369 GLIRLSVGLESPGDLREDLTQAIDA 393
Cdd:PRK05613 412 ATVRLSVGIEDIDDIIADLEGGFAA 436
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
15-395 |
1.65e-69 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 223.83 E-value: 1.65e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 15 AFRTRAIHVGNEIDPATGAVVPPIHLASTFRQPGAGE-----WGEFDYSRSG---NPTRSNLQNTLASLESGVGALAFAS 86
Cdd:PRK07050 9 ALQTRIVQPDDQIPPGFRSFVTPVARASTVVFPDLATmraldWRQDVQWRYGlhaTPTSLALAQRLAEIEGGRHALLQPS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 87 GMAAIHCVTM-LLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPD 165
Cdd:PRK07050 89 GLAAISLVYFgLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLEAPGSVTMEVPD 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 166 LPRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAVADKDLFDRLYFIQNATGAVLDP 245
Cdd:PRK07050 169 VPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADAELHAKLKLARMRLGIGVSA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 246 LSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLDGGFGAM-VTFELDAGIAETAK 324
Cdd:PRK07050 249 DDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLFsVVFDERYSPAQVDA 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1726208097 325 ACESTKLFHLAVSLGAVESL--IEQPATMSHASYDAADRarfgitdgLIRLSVGLESPGDLREDLTQAIDAAL 395
Cdd:PRK07050 329 FVEALELFAIGWSWGGACSLamPYDVASMRTAKWPHRGT--------LVRLYIGLEDEADLIADLEQALEAAL 393
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
18-394 |
8.18e-68 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 218.98 E-value: 8.18e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 18 TRAIHVGNEIDPATGAVVPPIHLASTFRQPG----AGEWGEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIhC 93
Cdd:TIGR01324 1 TRLIHSGRQPRFSQGSVNPPLQRASTVLFDShaaqRRAKGELTYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLAAV-T 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 94 VTML--LEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDLPRLAS 171
Cdd:TIGR01324 80 NSILafVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIPAIAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 172 IAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTlAVADKDLFDRLYFIQNATGAVLDPLSCFLV 251
Cdd:TIGR01324 160 AARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGT-VVANARTWDQLREHSYLMGQMVDADDAYTT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 252 SRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLDGGFGaMVTFELDAGIAETAKA-CESTK 330
Cdd:TIGR01324 239 LRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHEFWKRDFSGSSG-LFSFVLQRLTQKQVHAfLDHLQ 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1726208097 331 LFHLAVSLGAVESLI--EQPatmshasyDAADR--ARFGITDGLIRLSVGLESPGDLREDLTQAIDAA 394
Cdd:TIGR01324 318 LFGLGYSWGGYESLAlcNQP--------ELGHRpnIKRNLEGPLIRVHIGLENVDDLKADLKAGFEAI 377
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
30-376 |
2.33e-67 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 219.25 E-value: 2.33e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 30 ATGAVVPPihlaSTFRQPGAGEWGE----FDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIHCVTM-LLEQGDHV 104
Cdd:PLN02242 43 ATFTVMEP----DTMRRMFSGELGPdrdfYIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLqLCSSGGHV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 105 VAGCDLYGGAYRLL-HKICNRSGIDVTLVDMTDADAVSDAVND-RTKLIWAETIGNPRLTIPDLPRLASIAKQRGVLIGV 182
Cdd:PLN02242 119 VASNTLYGGTHALLaHFLPRKCNITTTFVDITDLEAVKKAVVPgKTKVLYFESISNPTLTVADIPELARIAHEKGVTVVV 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 183 DNTFgTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGtlAV-ADKDLFDRLYFIQNAT----GAVLDPLSCFLVSRGLKT 257
Cdd:PLN02242 199 DNTF-APMVLSPARLGADVVVHSISKFISGGADIIAG--AVcGPAELVNSMMDLHHGAlmllGPTMNPKVAFELSERLPH 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 258 LDLRIREQSKTALELSRWLEQHPkvRTVLYPGLESHPQHALAAKTL--DGGFGAMVTfeLDAGIAETAKAC-----ESTK 330
Cdd:PLN02242 276 LSLRMKEHCRRAMEYAKRMKELG--LKVIYPGLEDHPQHALLKSMAnkGYGFGGLLC--LDMDTEERANRLmrylqNSTQ 351
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1726208097 331 LFHLAVSLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVG 376
Cdd:PLN02242 352 FGFMAVSLGYYETLMSCSGSSTSSELDPEEKAAAGISPGLVRMSVG 397
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
40-391 |
5.57e-61 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 202.98 E-value: 5.57e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 40 LASTFRQPGAGewgeFDYSRSGNPTRSNLQNTLASLESGVGALAFASGMAAIHCVTM-LLEQGDHVVAGCDLYGGAYRLL 118
Cdd:PRK06702 42 LAALFNLEAEG----YIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAAIMLAVLnICSSGDHLLCSSTVYGGTFNLF 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 119 HKICNRSGIDVTLVDMT-DADAVSDAVNDRTKLIWAETIGNPRLTIPDLPRLASIAKQRGVLIGVDNTFGTPALVRPLEH 197
Cdd:PRK06702 118 GVSLRKLGIDVTFFNPNlTADEIVALANDKTKLVYAESLGNPAMNVLNFKEFSDAAKELEVPFIVDNTLATPYLCQAFEH 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 198 GIDIVMHSATKYLGGHSDCLGGTlaVADKDLFD-----------------RLYFIQN----------------ATGAVLD 244
Cdd:PRK06702 198 GANIIVHSTTKYIDGHASSLGGI--VIDGGNFDwtngkypelvepdpsyhGVSYVQNfgaaayivkarvqllrDYGNCMS 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 245 PLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLDGGFGAMVTFELDAGIAETAK 324
Cdd:PRK06702 276 PFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSNENYSLAQKYLKKGASGVLTFGIKGGLEAAKE 355
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1726208097 325 ACESTKLFHLAVSLGAVESLIEQPATMSHASYDAADRARFGITDGLIRLSVGLESPGDLREDLTQAI 391
Cdd:PRK06702 356 FIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRLSVGIEDVSDIIADLEAAL 422
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
1-394 |
1.86e-59 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 198.11 E-value: 1.86e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 1 MSDQDGRGEASRENafrTRAIHVGNEIDPATGAVVPPIHLASTFRQPGA----GEWGEFDYSRSGNPTRSNLQNTLASLE 76
Cdd:PRK05967 1 MAKKQLKTEKAGIN---TRLAHDGNDPGDYHGFVNPPVVHASTVLFPDAetmaTRGQKYTYGTRGTPTTDALCKAIDALE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 77 SGVGALAFASGMAAIhCVTML--LEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAE 154
Cdd:PRK05967 78 GSAGTILVPSGLAAV-TVPFLgfLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYDPEIGAGIAKLMRPNTKVVHTE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 155 TIGNPRLTIPDLPRLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTLAvADKDLFDRLYF 234
Cdd:PRK05967 157 APGSNTFEMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTVS-ANEKCWPQLLE 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 235 IQNATGAVLDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLDGGFGaMVTFE 314
Cdd:PRK05967 236 AHGTLGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASG-IFSFV 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 315 LDAGI----AETAKACESTKLFHLAVSLGAVESLieqpatMSHASYDAADRARfGITDG-LIRLSVGLESPGDLREDLTQ 389
Cdd:PRK05967 315 LAAGPekgkAKAHAFLDALEIFGLGYSWGGYESL------ALHVKLGDRTVAK-APYAGpVIRLQIGLEDVPDLKADLER 387
|
....*
gi 1726208097 390 AIDAA 394
Cdd:PRK05967 388 GFAAA 392
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
18-392 |
4.85e-58 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 194.18 E-value: 4.85e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 18 TRAIHVGNEIDPATGAVVPPIHLASTF--------RQPGAGEW-GEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGM 88
Cdd:PRK09028 7 TKIVSAGRDKKWTKGVINPPVFRASTVvfdtvaemRHAAKNRAnGEMFYGRRGTPTHFAFQAAIVELEGGAGTALYPSGA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 89 AAIHCVTM-LLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTIPDLP 167
Cdd:PRK09028 87 AAISNALLsFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPMIGEGIRELIRPNTKVLFLESPGSITMEVQDVP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 168 RLASIAKQRGVLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTlAVADKDLFDRLYFIQNATGAVLDPLS 247
Cdd:PRK09028 167 TLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGT-ATANEKHWDQLREHSYLMGQCTSPDD 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 248 CFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLDGGFGaMVTFELDAGIAETAKA-C 326
Cdd:PRK09028 246 VYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNG-LFSFVLKQGDPKAVTAlV 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1726208097 327 ESTKLFHLAVSLGAVESLIeqpatMSHASYDAADRA-RFGITDGLIRLSVGLESPGDLREDLTQAID 392
Cdd:PRK09028 325 EGMQHFKMGFSWGGFESLI-----LGVFGINKLRTAtNWDFSKPLIRLHIGLEDVDDLIADLEAGFE 386
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
18-388 |
4.49e-55 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 186.45 E-value: 4.49e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 18 TRAIHVGNEIDPATGAVVPPIHLASTF--------RQPGAGEW-GEFDYSRSGNPTRSNLQNTLASLESGVGALAFASGM 88
Cdd:PRK08114 8 TQLVNAGRSKKYTQGSVNSVIQRASSLvfdsveakKHATRNRAnGELFYGRRGTLTHFSLQEAMCELEGGAGCALYPCGA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 89 AAI-HCVTMLLEQGDHVVagcdLYGGAYR----LLHKICNRSGIDVTLVDMTDADAVSDAVNDRTKLIWAETIGNPRLTI 163
Cdd:PRK08114 88 AAVaNAILAFVEQGDHVL----MTGTAYEptqdFCSKILSKLGVTTTWFDPLIGADIAKLIQPNTKVVFLESPGSITMEV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 164 PDLPRLASIAKQRG--VLIGVDNTFGTPALVRPLEHGIDIVMHSATKYLGGHSDCLGGTlAVADKDLFDRLYFIQNATGA 241
Cdd:PRK08114 164 HDVPAIVAAVRSVNpdAVIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGT-AVANARCWEQLRENSYLMGQ 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 242 VLDPLSCFLVSRGLKTLDLRIREQSKTALELSRWLEQHPKVRTVLYPGLESHPQHALAAKTLDGGFGaMVTFELDAGI-- 319
Cdd:PRK08114 243 MVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTGSSG-LFSFVLKKKLtd 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1726208097 320 AETAKACESTKLFHLAVSLGAVESLI--EQPATMshasydAADRARFGI--TDGLIRLSVGLESPGDLREDLT 388
Cdd:PRK08114 322 EQLANYLDNFSLFSMAYSWGGFESLIlaNQPEEI------AAIRPAGEVdfTGTLIRLHIGLEDVDDLIADLA 388
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
80-212 |
1.02e-11 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 62.79 E-value: 1.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 80 GALAFASGMAAIHCVTM-LLEQGDHVVAGCDLYGGAYRllhKICNRSGIDVTLVDMTDADAVSDAVN--------DRTKL 150
Cdd:cd01494 19 KAVFVPSGTGANEAALLaLLGPGDEVIVDANGHGSRYW---VAAELAGAKPVPVPVDDAGYGGLDVAileelkakPNVAL 95
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1726208097 151 IWAETIGNPRLTIPDLPRLASIAKQRGVLIGVDNTFGTPA----LVRPLEHGIDIVMHSATKYLGG 212
Cdd:cd01494 96 IVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGAspapGVLIPEGGADVVTFSLHKNLGG 161
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
79-183 |
1.66e-03 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 40.37 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 79 VGALAFASGMAAI--HCVTMLLEQGDHVVAgCDLYGGAYrllHKICNRSGIDVTLVDMT-------DADAVSDAVNDRTK 149
Cdd:pfam00155 63 EAAVVFGSGAGANieALIFLLANPGDAILV-PAPTYASY---IRIARLAGGEVVRYPLYdsndfhlDFDALEAALKEKPK 138
|
90 100 110
....*....|....*....|....*....|....*..
gi 1726208097 150 LIWAETIGNPR---LTIPDLPRLASIAKQRGVLIGVD 183
Cdd:pfam00155 139 VVLHTSPHNPTgtvATLEELEKLLDLAKEHNILLLVD 175
|
|
| SufS_like |
cd06453 |
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ... |
118-183 |
2.03e-03 |
|
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Pssm-ID: 99746 [Multi-domain] Cd Length: 373 Bit Score: 39.76 E-value: 2.03e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1726208097 118 LHKICNRSGIDVTLVDMTDA-----DAVSDAVNDRTKLIWAETIGNPRLTIPDLPRLASIAKQRGVLIGVD 183
Cdd:cd06453 105 WQQLAERTGAKLKVVPVDDDgqldlEALEKLLTERTKLVAVTHVSNVLGTINPVKEIGEIAHEAGVPVLVD 175
|
|
| YnbB |
COG4100 |
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion ... |
84-212 |
2.20e-03 |
|
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 443276 Cd Length: 409 Bit Score: 40.09 E-value: 2.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 84 FASGMAAIHCVTM-LLEQGDHVVAGCdlyGGAYRLLHK-ICNRS---------GIDVTLVDMT-----DADAVSDAVNDR 147
Cdd:COG4100 81 IVSGTHAIALALFgVLRPGDELLSIT---GKPYDTLEEvIGIRGegqgslkefGISYRQVPLTedgkiDLEAIKKAINEK 157
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1726208097 148 TKLI---------WaetigNPRLTIPDLPRLASIAKQR--GVLIGVDNTFGTpaLV---RPLEHGIDIVMHSATKYLGG 212
Cdd:COG4100 158 TKMVliqrsrgysW-----RPSLTIEEIGEIIKFVKSInpDVICFVDNCYGE--FVetrEPTEVGADLMAGSLIKNPGG 229
|
|
| PRK07324 |
PRK07324 |
transaminase; Validated |
97-288 |
2.86e-03 |
|
transaminase; Validated
Pssm-ID: 235989 Cd Length: 373 Bit Score: 39.54 E-value: 2.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 97 LLEQGDHVVAgcdLYgGAYRLLHKICNRSGIDVTLVDMT-------DADAVSDAVNDRTKLIWAETIGNPRLTIPD---L 166
Cdd:PRK07324 100 LVEPGDHVIS---VY-PTYQQLYDIPESLGAEVDYWQLKeengwlpDLDELRRLVRPNTKLICINNANNPTGALMDrayL 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 167 PRLASIAKQRGVLIGVDNTF-------GTPALVRPLEHGIDIVMHSATKYLGGHSdcLGGTlaVADKDLFDRLYFIQNAT 239
Cdd:PRK07324 176 EEIVEIARSVDAYVLSDEVYrpldedgSTPSIADLYEKGISTNSMSKTYSLPGIR--VGWI--AANEEVIDILRKYRDYT 251
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1726208097 240 ---GAVLDPLscfLVSRGLKTLDL---RIREQSKTALE-LSRWLEQHPKVrTVLYP 288
Cdd:PRK07324 252 micAGVFDDM---LASLALEHRDAileRNRKIVRTNLAiLDEWVAKEPRV-SYVKP 303
|
|
| KBL_like |
cd06454 |
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ... |
68-242 |
3.09e-03 |
|
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.
Pssm-ID: 99747 [Multi-domain] Cd Length: 349 Bit Score: 39.47 E-value: 3.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 68 LQNTLASLESGVGALAFASGMAA-IHCVTMLLEQGDHVVA----------GCDLyGGAYRLLHKICnrsgidvtlvDMTD 136
Cdd:cd06454 51 LEEELAEFHGKEAALVFSSGYAAnDGVLSTLAGKGDLIISdslnhasiidGIRL-SGAKKRIFKHN----------DMED 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 137 ADAV--SDAVNDRTKLIWAETI----GnprlTIPDLPRLASIAKQRGVLIGVDNTFGTPALvrpLEHG------------ 198
Cdd:cd06454 120 LEKLlrEARRPYGKKLIVTEGVysmdG----DIAPLPELVDLAKKYGAILFVDEAHSVGVY---GPHGrgveefggltdd 192
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1726208097 199 IDIVMHSATKYLGGHsdclgGTLAVADKDLFDrlYFIQNATGAV 242
Cdd:cd06454 193 VDIIMGTLGKAFGAV-----GGYIAGSKELID--YLRSYARGFI 229
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
89-211 |
3.89e-03 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 39.15 E-value: 3.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 89 AAIHCVTMLLEQGDHVVAGCDLYGGAYRLLHKICNRSGIDVTLVDMT-----DADAVSDAVNDRTKLIWAETIGNPRLTI 163
Cdd:pfam00266 76 LVALSLGRSLKPGDEIVITEMEHHANLVPWQELAKRTGARVRVLPLDedgllDLDELEKLITPKTKLVAITHVSNVTGTI 155
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1726208097 164 PDLPRLASIAKQRGVLIGVDntfGTPALV-RPL---EHGIDIVMHSATKYLG 211
Cdd:pfam00266 156 QPVPEIGKLAHQYGALVLVD---AAQAIGhRPIdvqKLGVDFLAFSGHKLYG 204
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
82-289 |
5.90e-03 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 38.48 E-value: 5.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 82 LAFASGMAAIH-CVTMLLEQGDHVVAgCDLYGGAYRLLHKICNRSGIDVTLVD----MTDADAVSDAVNDRTKLIWAETI 156
Cdd:cd00609 63 VVTNGAQEALSlLLRALLNPGDEVLV-PDPTYPGYEAAARLAGAEVVPVPLDEeggfLLDLELLEAAKTPKTKLLYLNNP 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1726208097 157 GNP---RLTIPDLPRLASIAKQRGVLIGVDNTFG--------TPALVRPLEHGIDIVMHSATKYLGghsdcLGGT----L 221
Cdd:cd00609 142 NNPtgaVLSEEELEELAELAKKHGILIISDEAYAelvydgepPPALALLDAYERVIVLRSFSKTFG-----LPGLrigyL 216
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1726208097 222 AVADKDLFDRLYFIQNATGAVLDPLSCFLVSRGLKTLDLRIREQSKTALE----LSRWLEQHPKVRTVLYPG 289
Cdd:cd00609 217 IAPPEELLERLKKLLPYTTSGPSTLSQAAAAAALDDGEEHLEELRERYRRrrdaLLEALKELGPLVVVKPSG 288
|
|
| |
