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Conserved domains on  [gi|1712833658|gb|QDW17432|]
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tRNA (adenine-N1)-methyltransferase [Micrococcus sp. KBS0714]

Protein Classification

tRNA (adenine-N1)-methyltransferase( domain architecture ID 11457537)

tRNA (adenine-N1)-methyltransferase, such as tRNA (adenine(58)-N(1))-methyltransferase, which is a class I SAM-dependent methyltransferase that catalyzes the methylation of N(1)-adenine at position 58 (m1A58) in tRNA using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 16-271 4.30e-141

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 399.92  E-value: 4.30e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658  16 AGQRVQIKDAKGRLNTITLLPGGEFHSYQGVLRHDDLIGGFEGVVVENSAGQPYQVLRPLLNDFVLSMPRGATVVYPKDA 95
Cdd:COG2519     1 EGDRVLLTDPKGRKYLVRLEEGKKFHTHKGIIDHDDLIGKPEGSVVTTSKGKEFLVLRPTLYDYVLSMKRGTQIIYPKDA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658  96 AQIVQQADIFPGAVVVEAGVGSGALSMSLLRAVGDHGRLHSYERRPEFADVARANVEAFFgaEHPAWSVHLGDAQEEMPk 175
Cdd:COG2519    81 GYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFG--LPDNVELKLGDIREGID- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658 176 vhePGSVDRVVLDMLAPWECLDAVAEVLAPGGVWLNYVATATQLSRVAEAIRDSGrFTQVEANETLVRGWHLDGLAVRPD 255
Cdd:COG2519   158 ---EGDVDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESG-FTDIEAVETLLREWKVEGLAVRPE 233

                         250
                  ....*....|....*.
gi 1712833658 256 HRMVAHTGFLLTARRL 271
Cdd:COG2519   234 HRMVGHTGFLVFARKL 249
 
Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 16-271 4.30e-141

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 399.92  E-value: 4.30e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658  16 AGQRVQIKDAKGRLNTITLLPGGEFHSYQGVLRHDDLIGGFEGVVVENSAGQPYQVLRPLLNDFVLSMPRGATVVYPKDA 95
Cdd:COG2519     1 EGDRVLLTDPKGRKYLVRLEEGKKFHTHKGIIDHDDLIGKPEGSVVTTSKGKEFLVLRPTLYDYVLSMKRGTQIIYPKDA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658  96 AQIVQQADIFPGAVVVEAGVGSGALSMSLLRAVGDHGRLHSYERRPEFADVARANVEAFFgaEHPAWSVHLGDAQEEMPk 175
Cdd:COG2519    81 GYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFG--LPDNVELKLGDIREGID- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658 176 vhePGSVDRVVLDMLAPWECLDAVAEVLAPGGVWLNYVATATQLSRVAEAIRDSGrFTQVEANETLVRGWHLDGLAVRPD 255
Cdd:COG2519   158 ---EGDVDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESG-FTDIEAVETLLREWKVEGLAVRPE 233

                         250
                  ....*....|....*.
gi 1712833658 256 HRMVAHTGFLLTARRL 271
Cdd:COG2519   234 HRMVGHTGFLVFARKL 249
GCD14_N pfam14801
tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, ...
 11-61 3.79e-25

tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, itself a subunit of the tRNA methyltransferase complex that is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. The exact function of the N-terminus is not known but it is necessary for maintaining the overall folding and for full enzymatic activity.


Pssm-ID: 434222  Cd Length: 51  Bit Score: 96.03  E-value: 3.79e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1712833658  11 RGPLRAGQRVQIKDAKGRLNTITLLPGGEFHSYQGVLRHDDLIGGFEGVVV 61
Cdd:pfam14801   1 RGPFRAGDRVQLTDPKGRKHTITLEPGGEFHTHRGAIRHDDLIGRPEGSVV 51
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 110-208 4.43e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.11  E-value: 4.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658 110 VVEAGVGSGALSMSLLRAVGdhGRLHSYERRPEFADVARANVEAffgAEHPAWSVHLGDAQEEMPKvhEPGSVDRVVLDM 189
Cdd:cd02440     2 VLDLGCGTGALALALASGPG--ARVTGVDISPVALELARKAAAA---LLADNVEVLKGDAEELPPE--ADESFDVIISDP 74

                          90       100
                  ....*....|....*....|....*
gi 1712833658 190 LAPWEC------LDAVAEVLAPGGV 208
Cdd:cd02440    75 PLHHLVedlarfLEEARRLLKPGGV 99
rADc smart00650
Ribosomal RNA adenine dimethylases;
95-169 1.11e-04

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 42.11  E-value: 1.11e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1712833658   95 AAQIVQQADIFPGAVVVEAGVGSGALSMSLLRAVgdhGRLHSYERRPEFADVARanvEAFFGAEHpaWSVHLGDA 169
Cdd:smart00650   2 IDKIVRAANLRPGDTVLEIGPGKGALTEELLERA---KRVTAIEIDPRLAPRLR---EKFAAADN--LTVIHGDA 68
PRK08317 PRK08317
hypothetical protein; Provisional
 96-207 1.58e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 42.62  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658  96 AQIVQQADIFPGAVVVEAGVGSGALSMSLLRAVGDHGRLHSYERRPEFADVARANVEaffgAEHPAWSVHLGDAQE-EMP 174
Cdd:PRK08317    9 ARTFELLAVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKERAA----GLGPNVEFVRGDADGlPFP 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1712833658 175 KvhepGSVDRVVLDMLApwECLD----AVAE---VLAPGG 207
Cdd:PRK08317   85 D----GSFDAVRSDRVL--QHLEdparALAEiarVLRPGG 118
 
Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 16-271 4.30e-141

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 399.92  E-value: 4.30e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658  16 AGQRVQIKDAKGRLNTITLLPGGEFHSYQGVLRHDDLIGGFEGVVVENSAGQPYQVLRPLLNDFVLSMPRGATVVYPKDA 95
Cdd:COG2519     1 EGDRVLLTDPKGRKYLVRLEEGKKFHTHKGIIDHDDLIGKPEGSVVTTSKGKEFLVLRPTLYDYVLSMKRGTQIIYPKDA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658  96 AQIVQQADIFPGAVVVEAGVGSGALSMSLLRAVGDHGRLHSYERRPEFADVARANVEAFFgaEHPAWSVHLGDAQEEMPk 175
Cdd:COG2519    81 GYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFG--LPDNVELKLGDIREGID- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658 176 vhePGSVDRVVLDMLAPWECLDAVAEVLAPGGVWLNYVATATQLSRVAEAIRDSGrFTQVEANETLVRGWHLDGLAVRPD 255
Cdd:COG2519   158 ---EGDVDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESG-FTDIEAVETLLREWKVEGLAVRPE 233

                         250
                  ....*....|....*.
gi 1712833658 256 HRMVAHTGFLLTARRL 271
Cdd:COG2519   234 HRMVGHTGFLVFARKL 249
GCD14_N pfam14801
tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, ...
 11-61 3.79e-25

tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, itself a subunit of the tRNA methyltransferase complex that is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. The exact function of the N-terminus is not known but it is necessary for maintaining the overall folding and for full enzymatic activity.


Pssm-ID: 434222  Cd Length: 51  Bit Score: 96.03  E-value: 3.79e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1712833658  11 RGPLRAGQRVQIKDAKGRLNTITLLPGGEFHSYQGVLRHDDLIGGFEGVVV 61
Cdd:pfam14801   1 RGPFRAGDRVQLTDPKGRKHTITLEPGGEFHTHRGAIRHDDLIGRPEGSVV 51
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 71-269 1.90e-22

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


Pssm-ID: 312288  Cd Length: 242  Bit Score: 94.48  E-value: 1.90e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658  71 VLRPLLNDFVLSMPRGATVVYPKDAAQIVQQADIFPGAVVVEAGVGSGALSMSLLRAVGDHGRLHSYERRPEFADVARan 150
Cdd:pfam08704   5 VLQPTPELWTLNLPHRTQILYTPDISLITMMLELRPGSVVCESGTGSGSLSHAIIRTVAPTGHLFTFEFHEQRADKAR-- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658 151 vEAFFGAEHPAW-SVHLGDAQEEMPKVHEPGSVDRVVLDMLAPWECLDAVAEVLA-PGGVWLNYVATATQLSRVAEAIRD 228
Cdd:pfam08704  83 -EEFREHGIDQLvTVTHRDVCKEGFLTEVSGKADAVFLDLPSPWEAVPHAWKALKvEGGRFCSFSPCIEQVQRTCQALAE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658 229 SGrFTQVEANETLVRGW--------HLD--------------------------------GLAVRPDHRMVAHTGFLLTA 268
Cdd:pfam08704 162 LG-FTEISTLEVLLRVYdvrtvslpVIDlgidrekenertrteglsnddksednsgnsmlGTALKPMSEAVGHTGYLTFA 240


                  .
gi 1712833658 269 R 269
Cdd:pfam08704 241 T 241
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 110-228 1.01e-11

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 62.89  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658 110 VVEAGVGSGALSMSLLRAVGDHGRLHSYERRPEFADVARANVEAFFGAEHpaWSVHLGDAQEEMPKVhEPGSVDRVVLD- 188
Cdd:COG4122    20 ILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAGLADR--IRLILGDALEVLPRL-ADGPFDLVFIDa 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1712833658 189 --MLAPwECLDAVAEVLAPGGV-------WLNYVATATQLSRVAEAIRD 228
Cdd:COG4122    97 dkSNYP-DYLELALPLLRPGGLivadnvlWHGRVADPARRDPSTRAIRE 144
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 95-230 1.34e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 50.38  E-value: 1.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658  95 AAQIVQQADIFPGAVVVEAGVGSGALSMSLLRAvgdHGRLHSYERRPEFADVARANVEaffgAEHPAWSVHLGDAqEEMP 174
Cdd:COG2226    11 REALLAALGLRPGARVLDLGCGTGRLALALAER---GARVTGVDISPEMLELARERAA----EAGLNVEFVVGDA-EDLP 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1712833658 175 kvHEPGSVDRV----VLDMLA-PWECLDAVAEVLAPGGVWLNYVATATQLSRVAEAIRDSG 230
Cdd:COG2226    83 --FPDGSFDLVissfVLHHLPdPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLAEAG 141
Methyltransf_24 pfam13578
Methyltransferase domain; This family appears to be a methyltransferase domain.
 111-210 2.20e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 433324 [Multi-domain]  Cd Length: 106  Bit Score: 48.46  E-value: 2.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658 111 VEAGVGSGALSMSLLRAVGDHG--RLHSYERRPEFADvARANVEAFFGAEHpaWSVHLGDAQEEMPKVhEPGSVDRVVLD 188
Cdd:pfam13578   1 VEIGTYSGVSTLWLAAALRDNGlgRLTAVDPDPGAEE-AGALLRKAGLDDR--VRLIVGDSREALPSL-ADGPIDLLFID 76

                          90       100
                  ....*....|....*....|....*.
gi 1712833658 189 ML----APWECLDAVAEVLAPGGVWL 210
Cdd:pfam13578  77 GDhtyeAVLNDLELWLPRLAPGGVIL 102
COG3963 COG3963
Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];
95-208 6.66e-07

Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];


Pssm-ID: 443163  Cd Length: 193  Bit Score: 49.05  E-value: 6.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658  95 AAQIVQQADIFPGAVVVEAGVGSGALSMSLLRAVGDHGRLHSYERRPEFADVARanveaffgAEHPAWSVHLGDAQE--E 172
Cdd:COG3963    34 ARAMASEVDWSGAGPVVELGPGTGVFTRAILARGVPDARLLAVEINPEFAEHLR--------RRFPRVTVVNGDAEDlaE 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1712833658 173 MPKVHEPGSVDRVV--LdmlaPW---------ECLDAVAEVLAPGGV 208
Cdd:COG3963   106 LLAEHGIGKVDAVVsgL----PLlsfppelrrAILDAAFRVLAPGGV 148
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
44-153 8.73e-07

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 48.90  E-value: 8.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658  44 QGVLRHDDLIGGFEGV-----VVENSAGQPYQvlrpllnDFVLSMPRGATVVYPKDAAQIVQQADIFPGAVVVEAGVGSG 118
Cdd:pfam01135  13 YGVIKSDKVAEAMLAVdreefVPESFKSYAYE-------DIPLSIGYGQTISAPHMHAMMLELLELKPGMRVLEIGSGSG 85

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1712833658 119 ALSMSLLRAVGDHGRLHSYERRPEFADVARANVEA 153
Cdd:pfam01135  86 YLTACFARMVGEVGRVVSIEHIPELVEIARRNLEK 120
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 110-207 1.68e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 45.63  E-value: 1.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658 110 VVEAGVGSGALSMSLLRAVGdhGRLHSYERRPEFADVARANVEaffgAEHPAWSVHLGDAqEEMPkvHEPGSVDRVV--- 186
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG--ARVTGVDLSPEMLERARERAA----EAGLNVEFVQGDA-EDLP--FPDGSFDLVVssg 71

                          90       100
                  ....*....|....*....|....*
gi 1712833658 187 ----LDMLAPWECLDAVAEVLAPGG 207
Cdd:pfam13649  72 vlhhLPDPDLEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 110-208 4.43e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.11  E-value: 4.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658 110 VVEAGVGSGALSMSLLRAVGdhGRLHSYERRPEFADVARANVEAffgAEHPAWSVHLGDAQEEMPKvhEPGSVDRVVLDM 189
Cdd:cd02440     2 VLDLGCGTGALALALASGPG--ARVTGVDISPVALELARKAAAA---LLADNVEVLKGDAEELPPE--ADESFDVIISDP 74

                          90       100
                  ....*....|....*....|....*
gi 1712833658 190 LAPWEC------LDAVAEVLAPGGV 208
Cdd:cd02440    75 PLHHLVedlarfLEEARRLLKPGGV 99
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 95-169 6.09e-05

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 43.96  E-value: 6.09e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1712833658  95 AAQIVQQADIFPGAVVVEAGVGSGALSMSLLRAVgdhGRLHSYERRPEFADVARANVeaffgAEHPAWSVHLGDA 169
Cdd:COG0030    26 IRRIVDAAGITPGDTVLEIGPGLGALTRALLERA---ARVTAVEIDRRLAAILRETF-----AAYPNLTVIEGDA 92
rADc smart00650
Ribosomal RNA adenine dimethylases;
95-169 1.11e-04

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 42.11  E-value: 1.11e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1712833658   95 AAQIVQQADIFPGAVVVEAGVGSGALSMSLLRAVgdhGRLHSYERRPEFADVARanvEAFFGAEHpaWSVHLGDA 169
Cdd:smart00650   2 IDKIVRAANLRPGDTVLEIGPGKGALTEELLERA---KRVTAIEIDPRLAPRLR---EKFAAADN--LTVIHGDA 68
PRK08317 PRK08317
hypothetical protein; Provisional
 96-207 1.58e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 42.62  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658  96 AQIVQQADIFPGAVVVEAGVGSGALSMSLLRAVGDHGRLHSYERRPEFADVARANVEaffgAEHPAWSVHLGDAQE-EMP 174
Cdd:PRK08317    9 ARTFELLAVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKERAA----GLGPNVEFVRGDADGlPFP 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1712833658 175 KvhepGSVDRVVLDMLApwECLD----AVAE---VLAPGG 207
Cdd:PRK08317   85 D----GSFDAVRSDRVL--QHLEdparALAEiarVLRPGG 118
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 98-208 2.08e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 41.07  E-value: 2.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658  98 IVQQADIFPGAVVVEAGVGSGALSMSLLRAVGdhGRLHSYERRPEFADVARANVEAfFGAEHPAwSVHLGDAQEempkVH 177
Cdd:COG2230    43 ILRKLGLKPGMRVLDIGCGWGGLALYLARRYG--VRVTGVTLSPEQLEYARERAAE-AGLADRV-EVRLADYRD----LP 114

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1712833658 178 EPGSVDRVV-LDML-----APW-ECLDAVAEVLAPGGV 208
Cdd:COG2230   115 ADGQFDAIVsIGMFehvgpENYpAYFAKVARLLKPGGR 152
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 104-232 2.29e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 40.86  E-value: 2.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658 104 IFPGAVVVEAGVGSGALSMSLLRAVGDHGRLHSYERRPEFADVARANVEAFFGAEhpaWSVHLGDAqEEMPKVHEPGSVD 183
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQKLGFDN---VEFEQGDI-EELPELLEDDKFD 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1712833658 184 -----RVVLDMLAPWECLDAVAEVLAPGGVWLnyVATATQLSRVAEAIRDSGRF 232
Cdd:pfam13847  77 vvisnCVLNHIPDPDKVLQEILRVLKPGGRLI--ISDPDSLAELPAHVKEDSTY 128
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 96-227 1.39e-03

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 40.15  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658  96 AQIVQQADIFPGAVVVEAGVGSGALSMSLLRAvGDHGRLHSYERRPEFADVARANVEAfFGAEHpaWSVHLGDAQEEMPK 175
Cdd:COG2242   237 ALTLAKLALRPGDVLWDIGAGSGSVSIEAARL-APGGRVYAIERDPERAALIRANARR-FGVPN--VEVVEGEAPEALAD 312

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1712833658 176 VHEP------GSVDRVvldmlapWECLDAVAEVLAPGGVwlnYVATATQLSRVAEAIR 227
Cdd:COG2242   313 LPDPdavfigGSGGNL-------PEILEACWARLRPGGR---LVANAVTLETLALALE 360
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 106-280 1.53e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 39.13  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658 106 PGAVVVEAGVGSGALSMSLLRAVGdhGRLHSYERRPEFADVARANVEAffgAEHPAWSVHLGDAQEEMPKvhEPGSVDRV 185
Cdd:COG0500    26 KGGRVLDLGCGTGRNLLALAARFG--GRVIGIDLSPEAIALARARAAK---AGLGNVEFLVADLAELDPL--PAESFDLV 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658 186 VLDMLAPW-------ECLDAVAEVLAPGGVWLNyvatatqLSRVAEAIRDSGRFTQVEANETLVRGWHLDGLAVRPDHRM 258
Cdd:COG0500    99 VAFGVLHHlppeereALLRELARALKPGGVLLL-------SASDAAAALSLARLLLLATASLLELLLLLRLLALELYLRA 171

                         170       180
                  ....*....|....*....|..
gi 1712833658 259 VAHTGFLLTARRLASGEEALRL 280
Cdd:COG0500   172 LLAAAATEDLRSDALLESANAL 193
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
104-154 1.54e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 39.63  E-value: 1.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1712833658 104 IFPGAVVVEAGVGSGALSMSLLRAVGDHgrLHSYERRPEFADVARANVEAF 154
Cdd:COG4076    33 VKPGDVVLDIGTGSGLLSMLAARAGAKK--VYAVEVNPDIAAVARRIIAAN 81
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 106-210 1.88e-03

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 37.69  E-value: 1.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658 106 PGAVVVEAGVGSGALSMSLLRavgdHG-RLHSYERRPEFADVARANveaffgAEHPAWSVHLGDAqEEMPKvhEPGSVDR 184
Cdd:COG2227    24 AGGRVLDVGCGTGRLALALAR----RGaDVTGVDISPEALEIARER------AAELNVDFVQGDL-EDLPL--EDGSFDL 90

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1712833658 185 VV-LDMLA----PWECLDAVAEVLAPGGVWL 210
Cdd:COG2227    91 VIcSEVLEhlpdPAALLRELARLLKPGGLLL 121
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 101-226 2.11e-03

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 39.01  E-value: 2.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658 101 QADIFPGAVVVEAGVGSGALSMSLLRAVGDHGRLHSYERRPEFADVARANVEAFFGAEHPAwsVHLGDAQEEMPKVHEpg 180
Cdd:PRK00377   35 KLRLRKGDMILDIGCGTGSVTVEASLLVGETGKVYAVDKDEKAINLTRRNAEKFGVLNNIV--LIKGEAPEILFTINE-- 110

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1712833658 181 SVDRVVLD--MLAPWECLDAVAEVLAPGGVwlnYVATATQLSRVAEAI 226
Cdd:PRK00377  111 KFDRIFIGggSEKLKEIISASWEIIKKGGR---IVIDAILLETVNNAL 155
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
106-210 7.90e-03

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 35.57  E-value: 7.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712833658 106 PGAVVVEAGVGSGALSMSLLRAVGDHgRLHSYERRPEFADVARANveaffgaeHPAWSVHLGDAQEEMPkvhePGSVDRV 185
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERFPGA-RVTGVDLSPEMLARARAR--------LPNVRFVVADLRDLDP----PEPFDLV 67

                          90       100       110
                  ....*....|....*....|....*....|
gi 1712833658 186 VLDMLAPW-----ECLDAVAEVLAPGGVWL 210
Cdd:COG4106    68 VSNAALHWlpdhaALLARLAAALAPGGVLA 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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