|
Name |
Accession |
Description |
Interval |
E-value |
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
43-369 |
1.37e-72 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 232.55 E-value: 1.37e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 43 LRQQADRLSHLLQVMPAGVIVLDGYGIVRQANSQAIDLLGEPLE---GELWRTI---------IARSFKPRADDGHEVSL 110
Cdd:COG5000 85 LEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEeliGKPLEELlpeldlaelLREALERGWQEEIELTR 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 111 IDGRRVKLSITPLQNEpGQLIVLTDLTETRQlqarvshMQRLSALGKMVASLAHQIRTPLSAAMLYAANLTRSDLGQ--- 187
Cdd:COG5000 165 DGRRTLLVRASPLRDD-GYVIVFDDITELLR-------AERLAAWGELARRIAHEIKNPLTPIQLSAERLRRKLADKlee 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 188 --DATSGFAHKLTARLQELESQVNDMLLFAKSGEDQvvsnLTLADLKmAIAPNAITL----ADQAQLSVVFEGFEQDAAL 261
Cdd:COG5000 237 drEDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQ----LEPVDLN-ELLREVLALyepaLKEKDIRLELDLDPDLPEV 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 262 VGNLTALQGAVLNLVHNACQVSEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKTHGTGLGLAVVKSV 341
Cdd:COG5000 312 LADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIVKKI 391
|
330 340
....*....|....*....|....*...
gi 1680491246 342 VNAHKGQFAVANKAGSGAVFTMSFPAHA 369
Cdd:COG5000 392 VEEHGGTIELESRPGGGTTFTIRLPLAE 419
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
42-371 |
1.11e-64 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 210.09 E-value: 1.11e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 42 ALRQQADRLSHLLQVMPAGVIVLDGYGIVRQANSQAIDLLG------------------EPLEGELWRTIIARsfkpRAD 103
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGlsaeellgrplaelfpedSPLRELLERALAEG----QPV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 104 DGHEVSLI--DGRR--VKLSITPLQNEPGQ---LIVLTDLTETRQLQARVSHMQRLSALGKMVASLAHQIRTPLsAAMLY 176
Cdd:COG3852 77 TEREVTLRrkDGEErpVDVSVSPLRDAEGEggvLLVLRDITERKRLERELRRAEKLAAVGELAAGLAHEIRNPL-TGIRG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 177 AANLTRSDLGQDATSGFAHKLTA---RLQELesqVNDMLLFAKSGEdqvvSNLTLADLKMAIApNAITLADQ---AQLSV 250
Cdd:COG3852 156 AAQLLERELPDDELREYTQLIIEeadRLNNL---VDRLLSFSRPRP----PEREPVNLHEVLE-RVLELLRAeapKNIRI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 251 VFEGFEQDAALVGNLTALQGAVLNLVHNACQVSEPGTRVTVKASMAESL----------LSIEVADCGPGVSDSVKDKIF 320
Cdd:COG3852 228 VRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVtlgglrprlyVRIEVIDNGPGIPEEILDRIF 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1680491246 321 EPFFTTKTHGTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFPAHATQ 371
Cdd:COG3852 308 EPFFTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAE 358
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
22-368 |
7.95e-52 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 176.53 E-value: 7.95e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 22 DAHFSASSADEQFSDSAEVTALRQQADRLSHLLQVMPAGVIVLDGYGIVRQANSQAIDLLGEPLEGELWRTIIARSFKPR 101
Cdd:COG4191 11 LLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 102 ADDGHEVSLIDGRRVKLSITPLQNEPGQLivLTDLTETRQLQARVSHMQRLSALGKMVASLAHQIRTPLSAAMLYAANLt 181
Cdd:COG4191 91 EALLLLLLAALDAEENAELEELERDITEL--ERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELL- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 182 RSDLGQDATsgfAHKLTARLQELESQ-------VNDMLLFAKSGEDQvvsnLTLADLKMAIApNAITLAD----QAQLSV 250
Cdd:COG4191 168 RRRLEDEPD---PEELREALERILEGaeraaeiVRSLRAFSRRDEEE----REPVDLNELID-EALELLRprlkARGIEV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 251 VFEGFEQDAALVGNLTALQGAVLNLVHNACQVSEPGT--RVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTK- 327
Cdd:COG4191 240 ELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEggRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKp 319
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1680491246 328 -THGTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFPAH 368
Cdd:COG4191 320 vGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPLA 361
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
61-368 |
4.70e-48 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 165.85 E-value: 4.70e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 61 VIVLDGYGIVRQANSQAIDLLGEPLEGELWRTIIARSFKPRADDGHEVSLIDGRRVKLSITPLQNEPGQLIVLTDLTETR 140
Cdd:COG0642 15 LLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 141 QLQARVSHMQRLS-ALGKMVASLAHQIRTPLSAAMLYAANLTRSdlGQDATSGFAHKLTARLQELESQVNDMLLFAKSGE 219
Cdd:COG0642 95 LLLALLLLLEEANeAKSRFLANVSHELRTPLTAIRGYLELLLEE--LDEEQREYLETILRSADRLLRLINDLLDLSRLEA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 220 DQVVSNLT---LADLKMAIAPNAITLADQAQLSVVFEGFEQDAALVGNLTALQGAVLNLVHNACQVSEPGTRVTVKASMA 296
Cdd:COG0642 173 GKLELEPEpvdLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRRE 252
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1680491246 297 ESLLSIEVADCGPGVSDSVKDKIFEPFFTTK----THGTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFPAH 368
Cdd:COG0642 253 GDRVRISVEDTGPGIPPEDLERIFEPFFRTDpsrrGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
141-370 |
9.40e-47 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 159.69 E-value: 9.40e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 141 QLQARVSHMQRLSAL-GKMVASLAHQIRTPLSAAMLYAANLTRS-DLGQDATSGFAHKLTARLQELESQVNDMLLFAKSG 218
Cdd:COG2205 1 ELEEALEELEELERLkSEFLANVSHELRTPLTSILGAAELLLDEeDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 219 EDQVVSNLTLADLKmAIAPNAIT----LADQAQLSVVFEGFEQDAALVGNLTALQGAVLNLVHNACQVSEPGTRVTVKAS 294
Cdd:COG2205 81 SGKLSLELEPVDLA-ELLEEAVEelrpLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISAR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 295 MAESLLSIEVADCGPGVSDSVKDKIFEPFF----TTKTHGTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFPAHAT 370
Cdd:COG2205 160 REGDGVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
33-367 |
1.16e-42 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 153.17 E-value: 1.16e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 33 QFSDSAEVTALRQQADRLSHLLQVMPAGVIVLDGYGIVRQANSQAIDLLGEPLEGELWRTIIARSFKPRADDGHEVSLID 112
Cdd:COG5002 42 LLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 113 GRRVKLSITPLQNEPGQLIVLTDLTETRQLQARVSHMQRLSALGK-MVASLAHQIRTPLSAAMLYAANLTRSDLGQDATS 191
Cdd:COG5002 122 SELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRReFVANVSHELRTPLTSIRGYLELLLDGAADDPEER 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 192 ----GFAHKLTARLQELesqVNDMLLFAKSGEDQVVSNLT---LADLKMAIAPNAITLADQAQLSVVFEGFEQDAALVGN 264
Cdd:COG5002 202 reylEIILEEAERLSRL---VNDLLDLSRLESGELKLEKEpvdLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGD 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 265 LTALQGAVLNLVHNACQVSEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTT------KTHGTGLGLAVV 338
Cdd:COG5002 279 PDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVdksrsrETGGTGLGLAIV 358
|
330 340
....*....|....*....|....*....
gi 1680491246 339 KSVVNAHKGQFAVANKAGSGAVFTMSFPA 367
Cdd:COG5002 359 KHIVEAHGGRIWVESEPGKGTTFTITLPL 387
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
41-366 |
6.87e-41 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 150.65 E-value: 6.87e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 41 TALRQQADRLSHLLQVMPAGVIVLDGYGIVRQANSQAIDLLG---EPLEGELWRTI--------IARSFKPRADDGHEVS 109
Cdd:COG5805 150 EILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGaprEELIGKNLLELlhpcdkeeFKERIESITEVWQEFI 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 110 LI------DGR----RVKLS--ITPLQNEPGQLIVLTDLTETRQLQARVSHMQRLSALGKMVASLAHQIRTPLSA----- 172
Cdd:COG5805 230 IEreiitkDGRiryfEAVIVplIDTDGSVKGILVILRDITEKKEAEELMARSEKLSIAGQLAAGIAHEIRNPLTSikgfl 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 173 AMLYAanltrsdlGQDATSGFAHKLTARLQELESQVNDMLLFAKSGEDQVVS---NLTLADLKMAIAPNAITladqAQLS 249
Cdd:COG5805 310 QLLQP--------GIEDKEEYFDIMLSELDRIESIISEFLALAKPQAVNKEKeniNELIQDVVTLLETEAIL----HNIQ 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 250 VVFEGFEQDAALVGNLTALQGAVLNLVHNACQVSEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKTH 329
Cdd:COG5805 378 IRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEK 457
|
330 340 350
....*....|....*....|....*....|....*..
gi 1680491246 330 GTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:COG5805 458 GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
42-368 |
8.60e-40 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 147.43 E-value: 8.60e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 42 ALRQQADRLSHLLQVMPAGVIVLDGYGIVRQANSQAIDLLG---------------EPLEGELWRTIIARSFKpraDDGH 106
Cdd:COG5809 135 ALRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGisieeligksileliHSDDQENVAAFISQLLK---DGGI 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 107 ---EVSLI--DGRRVKLS-----ITPLQNEPGQLIVLTDLTETRQLQARVSHMQRLSALGKMVASLAHQIRTPLSA---- 172
Cdd:COG5809 212 aqgEVRFWtkDGRWRLLEasgapIKKNGEVDGIVIIFRDITERKKLEELLRKSEKLSVVGELAAGIAHEIRNPLTSlkgf 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 173 -AMLYAANLTRSDLgqdatsgFAHKLTARLQELESQVNDMLLFAKSGEDQVVSNltlaDLKmAIAPNAITLAD-QAQL-- 248
Cdd:COG5809 292 iQLLKDTIDEEQKT-------YLDIMLSELDRIESIISEFLVLAKPQAIKYEPK----DLN-TLIEEVIPLLQpQALLkn 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 249 -SVVFEGFEQDAALVGNLTALQGAVLNLVHNACQVSEPGTRVTVKAS-MAESLLSIEVADCGPGVSDSVKDKIFEPFFTT 326
Cdd:COG5809 360 vQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKaEDDDKVVISVTDEGCGIPEERLKKLGEPFYTT 439
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1680491246 327 KTHGTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFPAH 368
Cdd:COG5809 440 KEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIK 481
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
54-366 |
2.13e-38 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 145.11 E-value: 2.13e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 54 LQVMPAGVIVLDGYGIVRQANSQAIDLLG------------------EPLEGELWRT------IIARSFKPRADDGhevs 109
Cdd:PRK11360 268 LESIADGVIAIDRQGKITTMNPAAEVITGlqrhelvgkpyselfppnTPFASPLLDTlehgteHVDLEISFPGRDR---- 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 110 lidGRRVKLSITPLQNEPGQLI----VLTDLTETRQLQARVSHMQRLSALGKMVASLAHQIRTPLSAAMLYAANLTRsdl 185
Cdd:PRK11360 344 ---TIELSVSTSLLHNTHGEMIgalvIFSDLTERKRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYVQIWRQ--- 417
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 186 gQDATSGFAHKLTARLQE---LESQVNDMLLFAKSGEDQVVSnltlADLKmAIAPNAITLADQA--QLSVVFEgfeqdAA 260
Cdd:PRK11360 418 -QTSDPPSQEYLSVVLREvdrLNKVIDQLLEFSRPRESQWQP----VSLN-ALVEEVLQLFQTAgvQARVDFE-----TE 486
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 261 LVGNLTA-------LQGAVLNLVHNACQVSEPGTRVTVKASM-AESLLSIEVADCGPGVSDSVKDKIFEPFFTTKTHGTG 332
Cdd:PRK11360 487 LDNELPPiwadpelLKQVLLNILINAVQAISARGKIRIRTWQySDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTG 566
|
330 340 350
....*....|....*....|....*....|....
gi 1680491246 333 LGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:PRK11360 567 LGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
35-366 |
8.52e-36 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 134.14 E-value: 8.52e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 35 SDSAEVTALRQQADRLSHLLQVMPAGVIVLDGYGIVRQANSQAIDLLGEPLEGELWRTIIARS---------FKPRADDG 105
Cdd:COG5807 14 EKNQEFKLTEDSEFKFKQLFDSILEFVFFIDSKGEILECNDFAEDLYGLSQNEYIGKTFVEEKcilkdeqlyNKEAFDRI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 106 HEVSLIDGRRVKLSITPLQNEPGQ----LIVLTDLTETRQLQARVSHMQRLSALGKMVASLAHQIRTPLSAAMLYAaNLT 181
Cdd:COG5807 94 EISYLTKNGEFDEIIYPIYYKDGVilglITVYRDITKRKEAEDKLLRSEKLSVAGELAAGIAHEIRNPLTSIKGFL-QLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 182 RSDLGQDATSGFAHKLTARLQELESQVNDMLLFAKSGEdqvvSNLTLADLKMAIAPNAITLADQAQLS--VVFEGFEQDA 259
Cdd:COG5807 173 QESREDSEREEYFNIIISEIDRINTIITELLVLSKPKK----FNFKKLNLNDVLEDVIALLSTEAILKniSIKYDLADDE 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 260 ALV-GNLTALQGAVLNLVHNACQVSEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKTHGTGLGLAVV 338
Cdd:COG5807 249 PVInGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGDFVVISVKDEGIGIPEEVLEKIGEPFFTTKEEGTGLGLSIC 328
|
330 340
....*....|....*....|....*...
gi 1680491246 339 KSVVNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:COG5807 329 KKIIEEHNGTIEVESKPGKGTTFTIYLP 356
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
38-366 |
1.58e-31 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 123.03 E-value: 1.58e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 38 AEVTALRQQADRLshlLQVMPAGVIVLDGYGIVRQANSQAIDLLGEPLEGELWRTIIARSFKPRADDghEVSLIDGRRVK 117
Cdd:COG3290 77 EEIARLVEEREAV---LESIREGVIAVDRDGRITLINDAARRLLGLDAIGRPIDEVLAEVLETGERD--EEILLNGRVLV 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 118 LSITPLQNE---PGQLIVLTDLTETRQLQARVSHMQRLSalgKMVASLAHQIRTPLS--AAMLyaanltrsDLGQ-DATS 191
Cdd:COG3290 152 VNRVPIRDDgrvVGAVATFRDRTELERLEEELEGVKELA---EALRAQRHDFRNHLHtiSGLL--------QLGEyDEAL 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 192 GFAHKLTARLQELESQVNDMLlfaksgEDQVVSNLTLAdlKMAIAPN---AITLADQAQLSvvfEGFEQDAALVgnltal 268
Cdd:COG3290 221 EYIDEISEELQELIDSLLSRI------GNPVLAALLLG--KAARARErgiDLTIDIDSDLP---DLPLSDTDLV------ 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 269 qgAVL-NLVHNA---CQVSEPGTR-VTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKT-HGTGLGLAVVKSVV 342
Cdd:COG3290 284 --TILgNLLDNAieaVEKLPEEERrVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKLgEGRGLGLALVKQIV 361
|
330 340
....*....|....*....|....
gi 1680491246 343 NAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:COG3290 362 EKYGGTIEVESEEGEGTVFTVRLP 385
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
130-369 |
2.22e-30 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 121.01 E-value: 2.22e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 130 LIVLTDLTETRQLQARV---SHMQRLSALGKMVASLAHQIRTPLSAAMLYAANLTRSDLGQDATSGFaHKLTARLQELES 206
Cdd:COG5808 213 LLLQYNLLKRKTLLERViqeINTQKLELIGTFAASTAHEIRNPLTSIKGFIQLLQEKYPELEDQKYF-DIIQEEIQRINQ 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 207 QVNDMLLFAKSGEDQVVSNlTLADLKMAIAPNAITLADQAQLSVVFEGFEQDAALVGNLTALQGAVLNLVHNACQVSEPG 286
Cdd:COG5808 292 IVSEFLVLGKPTAKKLELD-DLNELIEEILSIIDSEANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKEG 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 287 TRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKTHGTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:COG5808 371 GKLTISIENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLP 450
|
...
gi 1680491246 367 AHA 369
Cdd:COG5808 451 LKK 453
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
140-371 |
9.06e-27 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 110.65 E-value: 9.06e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 140 RQLQARVSHMQRLSALGKMVASLAHQIRTPLSAAMLYAanltrSDLGQDATSGF-AHKLTarlQELESQVNDMllfaksg 218
Cdd:PRK10364 222 QLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLA-----KYFAERAPAGGeAHQLA---QVMAKEADRL------- 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 219 eDQVVSNLTLADLKMAIAPNAITLADQAQLSVVFegFEQDAALVG---------NLTALQG-------AVLNLVHNACQV 282
Cdd:PRK10364 287 -NRVVSELLELVKPTHLALQAVDLNDLINHSLQL--VSQDANSREiqlrftandTLPEIQAdpdrltqVLLNLYLNAIQA 363
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 283 SEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKTHGTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFT 362
Cdd:PRK10364 364 IGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFT 443
|
....*....
gi 1680491246 363 MSFPAHATQ 371
Cdd:PRK10364 444 LWLPVNITR 452
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
263-366 |
9.28e-27 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 102.73 E-value: 9.28e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 263 GNLTALQGAVLNLVHNACQVSEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTK-----THGTGLGLAV 337
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkrsrkIGGTGLGLSI 80
|
90 100
....*....|....*....|....*....
gi 1680491246 338 VKSVVNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
137-378 |
4.03e-26 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 110.15 E-value: 4.03e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 137 TETRQLQARVSHMQRLSALGKMVASLAHQIRTPLSAAMLYAanltrsDLGQDATSgfAHKLTAR-LQELESQ-------V 208
Cdd:PRK13837 432 TERDALERRLEHARRLEAVGTLASGIAHNFNNILGAILGYA------EMALNKLA--RHSRAARyIDEIISAgararliI 503
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 209 NDMLLFAKSGEdQVVSNLTLADLKMAIAPN-AITLADQAQLSVVFEGfeQDAALVGNLTALQGAVLNLVHNACQVSEPGT 287
Cdd:PRK13837 504 DQILAFGRKGE-RNTKPFDLSELVTEIAPLlRVSLPPGVELDFDQDQ--EPAVVEGNPAELQQVLMNLCSNAAQAMDGAG 580
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 288 RVTVKASMAE-----SLLS----------IEVADCGPGVSDSVKDKIFEPFFTTKTHGTGLGLAVVKSVVNAHKGQFAVA 352
Cdd:PRK13837 581 RVDISLSRAKlrapkVLSHgvlppgryvlLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQ 660
|
250 260
....*....|....*....|....*.
gi 1680491246 353 NKAGSGAVFTMSFPAHATQHVAPTTH 378
Cdd:PRK13837 661 STVGRGTRFDVYLPPSSKVPVAPQAF 686
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
271-365 |
4.81e-25 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 97.67 E-value: 4.81e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 271 AVLNLVHNACQVSEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTK----THGTGLGLAVVKSVVNAHK 346
Cdd:cd00075 4 VLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDksreGGGTGLGLAIVRRIVEAHG 83
|
90
....*....|....*....
gi 1680491246 347 GQFAVANKAGSGAVFTMSF 365
Cdd:cd00075 84 GRITVESEPGGGTTFTVTL 102
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
138-369 |
5.58e-25 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 105.70 E-value: 5.58e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 138 ETRQLQARVSHMqRLSALGK-----MVASLAHQIRTPLsAAMLYAANLTRSDLGQDATSGFAHKL---TARLQELesqVN 209
Cdd:PRK11100 235 ELRELAQALESM-RVKLEGKayveqYVQTLTHELKSPL-AAIRGAAELLQEDPPPEDRARFTGNIltqSARLQQL---ID 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 210 DMLLFAK---SGEDQVVSNLTLADLKMAIAPNAITLADQAQLSVVFEGfeQDAALVGNLTALQGAVLNLVHNACQVSEPG 286
Cdd:PRK11100 310 RLLELARleqRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRP--DDARVLGDPFLLRQALGNLLDNAIDFSPEG 387
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 287 TRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFT-----TKTHGTGLGLAVVKSVVNAHKGQFAVANKAGSGAVF 361
Cdd:PRK11100 388 GTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYSlprpaNGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLA 467
|
....*...
gi 1680491246 362 TMSFPAHA 369
Cdd:PRK11100 468 TLTLPRHF 475
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
272-366 |
4.70e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 89.79 E-value: 4.70e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 272 VLNLVHNACQVSEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKT--HGTGLGLAVVKSVVNAHKGQF 349
Cdd:cd16943 8 LLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvgEGTGLGLSLSYRIIQKHGGTI 87
|
90
....*....|....*..
gi 1680491246 350 AVANKAGSGAVFTMSFP 366
Cdd:cd16943 88 RVASVPGGGTRFTIILP 104
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-366 |
7.14e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 89.38 E-value: 7.14e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 268 LQGAVLNLVHNACQVSEPGTR----VTVKASMAES-LLSIEVADCGPGVSDSVKDKIFEPFFTTKTHGTGLGLAVVKSVV 342
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCerreLTIRTSPADDrAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSII 80
|
90 100
....*....|....*....|....
gi 1680491246 343 NAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:cd16920 81 EAHGGRLSVESPAGGGATFQFTLP 104
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
30-370 |
1.80e-21 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 95.62 E-value: 1.80e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 30 ADEQFSDSAEVTALRQQADRLSHLLQVMPAGVIVLDGYGIVRQANSQAIDLLGEPLEGELWRTIIARSFKPRADDGHEVS 109
Cdd:COG4251 152 LLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLL 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 110 LIDGRRVKLSITPLQNEPGQLIVLTDLTETRQLQARV-SHMQRLSA----LGKMVASLAHQIRTPLSAAMLYAANLTR-- 182
Cdd:COG4251 232 LLLLVLLLLLILLLLLLILVLELLELRLELEELEEELeERTAELERsneeLEQFAYVASHDLREPLRKISGFSQLLEEdy 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 183 -SDLGQDATS--GFAHKLTARLQELesqVNDMLLFAKSGE----------DQVVSNlTLADLKMAIAPNAITL------- 242
Cdd:COG4251 312 gDKLDEEGREylERIRDAAERMQAL---IDDLLAYSRVGRqelefepvdlNELLEE-VLEDLEPRIEERGAEIevgplpt 387
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 243 --ADQAQLSVVFEgfeqdaalvgnltalqgavlNLVHNACQVSEPGT--RVTVKASMAESLLSIEVADCGPGVSDSVKDK 318
Cdd:COG4251 388 vrGDPTLLRQVFQ--------------------NLISNAIKYSRPGEppRIEIGAEREGGEWVFSVRDNGIGIDPEYAEK 447
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1680491246 319 IFEPFFTTKTH----GTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFPAHAT 370
Cdd:COG4251 448 IFEIFQRLHSRdeyeGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAPA 503
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
263-366 |
3.16e-21 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 87.81 E-value: 3.16e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 263 GNLTALQGAVLNLVHNACQVSEPGTRVTVKASmAESLLSIEVADCGPGVSDSVKDKIFEPFFT---TKTHGTGLGLAVVK 339
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIVR 79
|
90 100
....*....|....*....|....*..
gi 1680491246 340 SVVNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:pfam02518 80 KLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
138-367 |
1.22e-20 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 92.62 E-value: 1.22e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 138 ETRQLQARVSHMQRLSALGKMVASLAHQIRTPLSAA--MLyaaNLTRSDLGQDATSGFAHKLTarLQEL---ESQVNDML 212
Cdd:COG5806 184 ENILLRKELQRAEKLEVVSELAASIAHEVRNPLTVVrgFI---QLLQEPELSDEKRKQYIRIA--LEELdraEAIITDYL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 213 LFAKSGEDQVVS---NLTLADLKMAIAPnaitLADQAQLSVVFEgFEQDAALVGNLTALQGAVLNLVHNACQVSEPGTRV 289
Cdd:COG5806 259 TFAKPQPEKLEKidvSEELEHVIDVLSP----YANMNNVEIQTE-LEPGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTL 333
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1680491246 290 TVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKTHGTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFPA 367
Cdd:COG5806 334 TIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPL 411
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
137-366 |
1.85e-19 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 89.37 E-value: 1.85e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 137 TETRQLQARVSHM--------QRLSALGkmvASLAHQIRTPLSAAMLYAANLTRSDLGQDATSGFAHKLTARLQELESQV 208
Cdd:TIGR01386 218 AELRELAQSFNAMlgrledafQRLSQFS---ADLAHELRTPLTNLLGQTQVALSQPRTGEEYREVLESNLEELERLSRMV 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 209 NDMLLFAKSgeDQVVSNLTLADLKMAiAPNAIT------LADQAQLSVVFEGfeqDAALVGNLTALQGAVLNLVHNACQV 282
Cdd:TIGR01386 295 SDMLFLARA--DNGQLALERVRLDLA-AELAKVaeyfepLAEERGVRIRVEG---EGLVRGDPQMFRRAISNLLSNALRH 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 283 SEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFF------TTKTHGTGLGLAVVKSVVNAHKGQfAVANKAG 356
Cdd:TIGR01386 369 TPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYrvdparSNSGEGTGLGLAIVRSIMEAHGGR-ASAESPD 447
|
250
....*....|
gi 1680491246 357 SGAVFTMSFP 366
Cdd:TIGR01386 448 GKTRFILRFP 457
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
142-347 |
5.66e-18 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 84.98 E-value: 5.66e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 142 LQARVSHMQRLsalgkmVASLAHQIRTPLSAAMLYAANLTRSdlgqdatSGFAHKLTaRL----QELESQVNDMLLFAKS 217
Cdd:PRK09470 236 LERMMTSQQRL------LSDISHELRTPLTRLQLATALLRRR-------QGESKELE-RIeteaQRLDSMINDLLVLSRN 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 218 gedQVVSNLT-----LADLKMAIAPNAITLADQAQLSVVFEGFEQDAALVGNLTALQGAVLNLVHNACQVSEpgTRVTVK 292
Cdd:PRK09470 302 ---QQKNHLEretfkANSLWSEVLEDAKFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSH--TKIEVA 376
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1680491246 293 ASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTT------KTHGTGLGLAVVKSVVNAHKG 347
Cdd:PRK09470 377 FSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVdeardrESGGTGLGLAIVENAIQQHRG 437
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-363 |
8.12e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 78.27 E-value: 8.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 268 LQGAVLNLVHNAC----QVSEPgtRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKT--HGTGLGLAVVKSV 341
Cdd:cd16976 1 IQQVLMNLLQNALdamgKVENP--RIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPvgKGTGLGLSISYGI 78
|
90 100
....*....|....*....|..
gi 1680491246 342 VNAHKGQFAVANKAGSGAVFTM 363
Cdd:cd16976 79 VEEHGGRLSVANEEGAGARFTF 100
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
74-368 |
1.09e-17 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 83.91 E-value: 1.09e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 74 NSQAI-DLLGEPlegELWRTIIARSFkpraDDGHEVSLIDGRRVKLSITPLQNepGQ-LIVLTDLTETRQLQArvshMQR 151
Cdd:PRK11006 139 NGQNIlNLLRYP---EFTQYLKTRDF----SRPLTLVLNNGRHLEIRVMPYTE--GQlLMVARDVTQMHQLEG----ARR 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 152 lsalgKMVASLAHQIRTPLSAAMLYAANLTRSDLGQDATSGFAHKLTARLQELESQVNDMLLFAK-------SGEDQVVS 224
Cdd:PRK11006 206 -----NFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKieaaptiDLNEKVDV 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 225 NLTLADLKMaiapNAITLADQAQLSVvfegFEQDAAL--VGNLTALQGAVLNLVHNACQVSEPGTRVTVKASMAESLLSI 302
Cdd:PRK11006 281 PMMLRVLER----EAQTLSQGKHTIT----FEVDNSLkvFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEF 352
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1680491246 303 EVADCGPGVSDSVKDKIFEPFF------TTKTHGTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFPAH 368
Cdd:PRK11006 353 SVEDNGPGIAPEHIPRLTERFYrvdkarSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPER 424
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
140-384 |
6.71e-17 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 82.38 E-value: 6.71e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 140 RQLQARVSHMQRLSALGKMVASLA------------HQIRTPLSAAmLYAANL---TRSDLGQDATSGFAHKLTARLQEL 204
Cdd:PRK15347 371 DTLENKVAERTQALAEAKQRAEQAnkrksehlttisHEIRTPLNGV-LGALELlqnTPLTAEQMDLADTARQCTLSLLAI 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 205 esqVNDMLLFAKSGEDQVVSNLTLADLkmaiapnaITLADQAQLSVVFEGFEQDAALVGNLTA------------LQGAV 272
Cdd:PRK15347 450 ---INNLLDFSRIESGQMTLSLEETAL--------LPLLDQAMLTIQGPAQSKSLTLRTFVGAhvplylhldslrLRQIL 518
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 273 LNLVHNACQVSEPG-TRVTVKASmaESLLSIEVADCGPGVSDSVKDKIFEPFFTTKTH--GTGLGLAVVKSVVNAHKGQF 349
Cdd:PRK15347 519 VNLLGNAVKFTETGgIRLRVKRH--EQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHsqGTGLGLTIASSLAKMMGGEL 596
|
250 260 270
....*....|....*....|....*....|....*
gi 1680491246 350 AVANKAGSGAVFTMSFPahATQHVAPTTHSdGELV 384
Cdd:PRK15347 597 TLFSTPGVGSCFSLVLP--LNEYAPPEPLK-GELS 628
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
274-366 |
8.91e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 75.40 E-value: 8.91e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 274 NLVHNACQVS----EPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKTHGT-GLGLAVVKSVVNAHKGQ 348
Cdd:cd16915 7 NLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGErGIGLALVRQSVERLGGS 86
|
90
....*....|....*...
gi 1680491246 349 FAVANKAGSGAVFTMSFP 366
Cdd:cd16915 87 ITVESEPGGGTTFSIRIP 104
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-366 |
2.52e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 73.97 E-value: 2.52e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 268 LQGAVLNLVHNACQVSEPG-------TRVTVKASMAES----LLSIEVADCGPGVSDSVKDKIFEPFFTTKTHGTGLGLA 336
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSggeiilrTRTQRQVTLGHPrhrlALRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLA 80
|
90 100 110
....*....|....*....|....*....|
gi 1680491246 337 VVKSVVNAHKGQFAVANKAGSgAVFTMSFP 366
Cdd:cd16918 81 IAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-366 |
4.45e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 73.39 E-value: 4.45e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 268 LQGAVLNLVHNACQVSEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFF------TTKTHGTGLGLAVVKSV 341
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYrvdierCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 1680491246 342 VNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFP 105
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
155-370 |
1.02e-15 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 78.11 E-value: 1.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 155 LGKMVAS-------LAHQIRTPLSA-----AMLyaANLTRS-------DLGQdatsgfahkltarlqeLESQVNDMLLFA 215
Cdd:PRK10604 205 INALIASkkqlidgIAHELRTPLVRlryrlEMS--DNLSAAesqalnrDIGQ----------------LEALIEELLTYA 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 216 KSGEDQVVSNLTLADLKM---AIAPNAITLADQAQLSVVFEGFEQDAALvgNLTALQGAVLNLVHNACQVSepGTRVTVK 292
Cdd:PRK10604 267 RLDRPQNELHLSEPDLPAwlsTHLADIQAVTPEKTVRLDTPHQGDYGAL--DMRLMERVLDNLLNNALRYA--HSRVRVS 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 293 ASMAESLLSIEVADCGPGVSDSVKDKIFEPFF------TTKTHGTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:PRK10604 343 LLLDGNQACLIVEDDGPGIPPEERERVFEPFVrldpsrDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
....
gi 1680491246 367 AHAT 370
Cdd:PRK10604 423 VWHN 426
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
140-366 |
1.72e-15 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 78.19 E-value: 1.72e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 140 RQLQARVSHMQRLSALGKMVASLAHQIRTPLSA--AMLYAANLTRSDLGQDATSGFAHKLTARLQELESQVNDMLLFAKS 217
Cdd:COG4192 418 RQTQDELIQAAKMAVVGQTMTSLAHELNQPLNAmsMYLFSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSRK 497
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 218 GEDQvvsnLTLADLKMAIAPNAITLADQAQLSVVFEGFEQDAALVGNLTALQGAVLNLVHNACQVSEPGTRVTVKASMAE 297
Cdd:COG4192 498 SDTP----LQPVDLRQVIEQAWELVESRAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNA 573
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1680491246 298 SLLSIEVADCGPGVSDSvkDKIFEPFFTTKTHGTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:COG4192 574 ENLRVAISDNGNGWPLV--DKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDLYLASTLERGAMVILEFN 640
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
160-369 |
1.80e-15 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 77.50 E-value: 1.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 160 ASLAHQIRTPLSaamlyaaNL-TRSD--LGQDAT-SGFAHKLTARLQELE---SQVNDMLLFAKSGEDQVVSN---LTLA 229
Cdd:PRK09835 267 ADIAHEIRTPIT-------NLiTQTEiaLSQSRSqKELEDVLYSNLEELTrmaKMVSDMLFLAQADNNQLIPEkkmLDLA 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 230 DLKMAIAPNAITLADQAQLSVVFEGFEqdAALVGNLTALQGAVLNLVHNACQVSEPGTRVTVKASMAESLLSIEVADCGP 309
Cdd:PRK09835 340 DEVGKVFDFFEAWAEERGVELRFVGDP--CQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGT 417
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1680491246 310 GVSDSVKDKIFEPFFTT------KTHGTGLGLAVVKSVVNAHKGQFAVANKAGSgAVFTMSFPAHA 369
Cdd:PRK09835 418 PIAPEHLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTVAVTSDARG-TRFVISLPRLE 482
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
266-366 |
2.63e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 71.41 E-value: 2.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 266 TALQGAVLNLVHNACQVSE------PGTRVTVKASmAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKTHGTGLGLAVVK 339
Cdd:cd16944 3 TQISQVLTNILKNAAEAIEgrpsdvGEVRIRVEAD-QDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIVK 81
|
90 100
....*....|....*....|....*..
gi 1680491246 340 SVVNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:cd16944 82 KIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
141-367 |
4.56e-15 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 75.77 E-value: 4.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 141 QLQARVSHM---QRLSAlgkmvASLAHQIRTPLSAAMLYAANLTRSDlGQDATSgfahkLTARLQELESQVNDMLLFAKS 217
Cdd:PRK10755 125 QLVSRLTSTldqERLFT-----ADVAHELRTPLAGIRLHLELLEKQH-HIDVAP-----LIARLDQMMHTVEQLLQLARA 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 218 GEDQVVSN-LTLADLKMAIAPNA---ITLADQAQLSVVFEGFEQDAALVGNLTALQGAVLNLVHNACQVSEPGTRVTVKA 293
Cdd:PRK10755 194 GQSFSSGHyQTVKLLEDVILPSQdelSEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKL 273
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1680491246 294 SMAESLLSIEVADCGPGVSDSVKDKIFEPF--FTTKTHGTGLGLAVVKSVVNAHKGQFAVANKA-GSGAVFTMSFPA 367
Cdd:PRK10755 274 SQEDGGAVLAVEDEGPGIDESKCGELSKAFvrMDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQeRSGTRAWVWLPK 350
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
272-366 |
5.77e-15 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 70.21 E-value: 5.77e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 272 VLNLVHNACQVSEPGTRVTVKASMAE-SLLSIEVADCGPGVSDSVKDKIFEPF------FTTKTHGTGLGLAVVKSVVNA 344
Cdd:cd16925 9 VLNLLSNAFKFTPDGGRIRCILEKFRlNRFLLTVSDSGPGIPPNLREEIFERFrqgdgsSTRAHGGTGLGLSIVKEFVEL 88
|
90 100
....*....|....*....|..
gi 1680491246 345 HKGQFAVANKAGSGAVFTMSFP 366
Cdd:cd16925 89 HGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
263-365 |
1.27e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 69.36 E-value: 1.27e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 263 GNLTALQGAVLNLVHNACQVSEPGTRVTVKASmAESLLSIEVADCGPGVSDSVKDKIFEPFF---TTKTHGTGLGLAVVK 339
Cdd:cd16940 9 GDALLLFLLLRNLVDNAVRYSPQGSRVEIKLS-ADDGAVIRVEDNGPGIDEEELEALFERFYrsdGQNYGGSGLGLSIVK 87
|
90 100
....*....|....*....|....*.
gi 1680491246 340 SVVNAHKGQFAVANKAGSGAVFTMSF 365
Cdd:cd16940 88 RIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
272-366 |
3.00e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 68.29 E-value: 3.00e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 272 VLNLVHNACQVSEPGTrVTVKAS-----MAESLLSIEVADCGPGVSDSVKDKIFEPF------FTTKTHGTGLGLAVVKS 340
Cdd:cd16922 5 LLNLLGNAIKFTEEGE-VTLRVSleeeeEDGVQLRFSVEDTGIGIPEEQQARLFEPFsqadssTTRKYGGTGLGLAISKK 83
|
90 100
....*....|....*....|....*.
gi 1680491246 341 VVNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:cd16922 84 LVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
133-366 |
9.14e-14 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 72.76 E-value: 9.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 133 LTDLTETRQLQArvshmQRLSALGKMVASLAHQIRTPLSAAMLYAANLTRsDLgqdATSGFAHKLTA---RLQELESQ-- 207
Cdd:PRK10490 647 LTASEEQARLAS-----EREQLRNALLAALSHDLRTPLTVLFGQAEILTL-DL---ASEGSPHARQAseiRQQVLNTTrl 717
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 208 VNDMLLFAK--SG------EDQVVSNLTLADLKM---AIAPNAITLADQAQLSVVFegfeQDAALvgnltaLQGAVLNLV 276
Cdd:PRK10490 718 VNNLLDMARiqSGgfnlrkEWLTLEEVVGSALQMlepGLSGHPINLSLPEPLTLIH----VDGPL------FERVLINLL 787
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 277 HNACQVSEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFftTKTH------GTGLGLAVVKSVVNAHKGQFA 350
Cdd:PRK10490 788 ENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKF--ARGNkesaipGVGLGLAICRAIVEVHGGTIW 865
|
250
....*....|....*.
gi 1680491246 351 VANKAGSGAVFTMSFP 366
Cdd:PRK10490 866 AENRPEGGACFRVTLP 881
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
268-366 |
2.80e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 65.86 E-value: 2.80e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 268 LQGAVLNLVHNACQVSEPGTRVTVKAS---------------MAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKT--HG 330
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETSnqrvdadyalnyrdlIPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEvgKG 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 1680491246 331 TGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:cd16919 81 TGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-358 |
8.20e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 64.01 E-value: 8.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 268 LQGAVLNLVHNACQVSepGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFF----TTKTHGTGLGLAVVKSVVN 343
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYrgdnARGTSGTGLGLAIVQRISD 78
|
90
....*....|....*
gi 1680491246 344 AHKGQFAVANKAGSG 358
Cdd:cd16950 79 AHGGSLTLANRAGGG 93
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
267-365 |
1.84e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 63.25 E-value: 1.84e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 267 ALQGAVLNLVHNACQVSEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKTHGT-----GLGLAVVKSV 341
Cdd:cd16975 4 LLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRsgghyGMGLYIAKNL 83
|
90 100
....*....|....*....|....
gi 1680491246 342 VNAHKGQFAVANKAGSGAVFTMSF 365
Cdd:cd16975 84 VEKHGGSLIIENSQKGGAEVTVKI 107
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-366 |
2.28e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 62.87 E-value: 2.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 268 LQGAVLNLVHNACQVSEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKTH------GTGLGLAVVKSV 341
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrnrasgGSGLGLAICHNI 84
|
90 100
....*....|....*....|....*
gi 1680491246 342 VNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:cd16946 85 ALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-367 |
4.49e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 61.96 E-value: 4.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 268 LQGAVLNLVHNACQVSePGTrVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFF------TTKTHGTGLGLAVVKSV 341
Cdd:cd16949 1 LARALENVLRNALRYS-PSK-ILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdsarDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 1680491246 342 VNAHKGQFAVANKAGSGAVFTMSFPA 367
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
51-348 |
5.37e-12 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 66.26 E-value: 5.37e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 51 SHLLQVMPAGVIVLDGYGIVRQANSQAIDLL--------GEPLEgELWRTI---IARSFKPrADDGH-----EVSL-IDG 113
Cdd:PRK11073 10 GQILNSLINSILLLDDDLAIHYANPAAQQLLaqssrklfGTPLP-ELLSYFslnIELMRES-LQAGQgftdnEVTLvIDG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 114 RRVKLSITpLQNEPGQLIVLtdltETRQL--QARVS-----HMQRLSAlGKMVASLAHQIRTPLsAAMLYAANLTRSDLG 186
Cdd:PRK11073 88 RSHILSLT-AQRLPEGMILL----EMAPMdnQRRLSqeqlqHAQQVAA-RDLVRGLAHEIKNPL-GGLRGAAQLLSKALP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 187 QDATSGFAHKLTARLQELESQVNDMLLFAKSGEdQVVSNL--------TLADLKMaiaPNAITLADQAQLSVvfEGFEQD 258
Cdd:PRK11073 161 DPALTEYTKVIIEQADRLRNLVDRLLGPQRPGT-HVTESIhkvaervvQLVSLEL---PDNVRLIRDYDPSL--PELAHD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 259 AAlvgnltALQGAVLNLVHNACQV-SEPGTRVTVKASMAESLL----------SIEVADCGPGVSDSVKDKIFEPFFTTK 327
Cdd:PRK11073 235 PD------QIEQVLLNIVRNALQAlGPEGGTITLRTRTAFQLTlhgeryrlaaRIDIEDNGPGIPPHLQDTLFYPMVSGR 308
|
330 340
....*....|....*....|.
gi 1680491246 328 THGTGLGLAVVKSVVNAHKGQ 348
Cdd:PRK11073 309 EGGTGLGLSIARNLIDQHSGK 329
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
118-367 |
9.77e-12 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 66.23 E-value: 9.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 118 LSITPLQNEPGQLIVL----TDLTETRQLQARVSHMQRLSALGKMVASLAHQ--------------IRTPLSAAMLYAAN 179
Cdd:PRK13557 122 LFVSPVYNDAGDLVYFfgsqLDVSRRRDAEDALRQAQKMEALGQLTGGIAHDfnnllqvmsgyldvIQAALSHPDADRGR 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 180 LTRSDLGQDATSGFAHKLT------ARLQELESQV---NDMLlfakSGEDQVVSNlTLAD---LKMAIAPNAITL-ADQA 246
Cdd:PRK13557 202 MARSVENIRAAAERAATLTqqllafARKQRLEGRVlnlNGLV----SGMGELAER-TLGDavtIETDLAPDLWNCrIDPT 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 247 QLSVvfegfeqdaalvgnltalqgAVLNLVHNACQVSEPGTRVTVK---------ASMAESLL------SIEVADCGPGV 311
Cdd:PRK13557 277 QAEV--------------------ALLNVLINARDAMPEGGRVTIRtrnveiedeDLAMYHGLppgryvSIAVTDTGSGM 336
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1680491246 312 SDSVKDKIFEPFFTTKTH--GTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFPA 367
Cdd:PRK13557 337 PPEILARVMDPFFTTKEEgkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPA 394
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
271-367 |
1.35e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 60.52 E-value: 1.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 271 AVLNLVHNACQVSEpgTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFF------TTKTHGTGLGLAVVKSVVNA 344
Cdd:cd16939 4 ALDNLLRNALRYAH--RTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVrldpsrDRATGGFGLGLAIVHRVALW 81
|
90 100
....*....|....*....|...
gi 1680491246 345 HKGQFAVANKAGSGAVFTMSFPA 367
Cdd:cd16939 82 HGGHVECDDSELGGACFRLTWPR 104
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-361 |
2.87e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 59.78 E-value: 2.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 268 LQGAVLNLVHNACQVSEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFT-----TKTHGTGLGLAVVKSVV 342
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAFVQEVA 84
|
90
....*....|....*....
gi 1680491246 343 NAHKGQFAVANKAGSGAVF 361
Cdd:cd16945 85 QLHGGRITLRNRPDGVLAF 103
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
126-366 |
3.04e-11 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 64.54 E-value: 3.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 126 EPGQLIVLTDLTETRQ---------LQARVSHMQRLSALGKMVASLAHQIRTPL---SAAMlyaANLTR--SDLGQDAts 191
Cdd:TIGR02938 238 QPYLLLTIADISNLREeqerarlsaLQALMAEEERLEAIRETLSAAIHRLQGPMnliSAAI---SVLQRrgDDAGNPA-- 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 192 gfahkltarlqelesqVNDMLLFAKSGEDQVVSNL------TLADLKMAIAPN-----AITLADQAQLS----VVFEGFE 256
Cdd:TIGR02938 313 ----------------SAAMLQQALSAGREHMEALrqvipqSPQEIVVPVNLNqilrdVITLSTPRLLAagivVDWQPAA 376
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 257 QDAALVGNLTALQGAVLNLVHNACQ-VSEPGTR---VTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKT---H 329
Cdd:TIGR02938 377 TLPAILGRELQLRSLFKALVDNAIEaMNIKGWKrreLSITTALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKGgsrK 456
|
250 260 270
....*....|....*....|....*....|....*..
gi 1680491246 330 GTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:TIGR02938 457 HIGMGLSVAQEIVADHGGIIDLDDDYSEGCRIIVEFR 493
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
150-366 |
2.53e-10 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 61.51 E-value: 2.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 150 QRLSALGKMVASLAHQIRTPLSAAMLYAANLtrsDLGQDATSG---------FAHKLTARLQELESQVNDMLLFAKSGED 220
Cdd:PRK09303 146 EQLKFKDRVLAMLAHDLRTPLTAASLALETL---ELGQIDEDTelkpalieqLQDQARRQLEEIERLITDLLEVGRTRWE 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 221 QVVSNLTLADLKMAIAPNAITLADQAQL-SVVFE-GFEQDAALV-GNLTALQGAVLNLVHNACQVSEPGTRVTVkasmae 297
Cdd:PRK09303 223 ALRFNPQKLDLGSLCQEVILELEKRWLAkSLEIQtDIPSDLPSVyADQERIRQVLLNLLDNAIKYTPEGGTITL------ 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 298 SLL-------SIEVADCGPGVSDSVKDKIFEPFFTTK----THGTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:PRK09303 297 SMLhrttqkvQVSICDTGPGIPEEEQERIFEDRVRLPrdegTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-366 |
4.42e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 56.24 E-value: 4.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 268 LQGAVLNLVHNACQVSEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFF----TTKTHGTGLGLAVVKSVVN 343
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYrgdnSRNTEGAGLGLSIAKAIIE 80
|
90 100
....*....|....*....|...
gi 1680491246 344 AHKGQFAvANKAGSGAVFTMSFP 366
Cdd:cd16923 81 LHGGSAS-AEYDDNHDLFKVRLP 102
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
135-374 |
5.14e-10 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 61.29 E-value: 5.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 135 DLTETRQL-----QARVSHMQRLSALGKMVASLAHQIRTPLSAAMLYAANLTRSDLGQDATSGFAHKLTARLQELESQVN 209
Cdd:PRK09959 687 DITETRDLihaleVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIG 766
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 210 DMLLFAK--SGEDQVVSN-LTLADLKMAIAPNAITLADQAQLSVVFEGFEQDAALVG-NLTALQGAVLNLVHNACQVSEP 285
Cdd:PRK09959 767 EILDVDKieSGNYQLQPQwVDIPTLVQNTCHSFGAIAASKSIALSCSSTFPDHYLVKiDPQAFKQVLSNLLSNALKFTTE 846
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 286 GTrVTVKASMAE-----SLLSIEVADCGPGVSDSVKDKIFEPFFTT----KTHGTGLGLAVVKSVVNAHKGQFAVANKAG 356
Cdd:PRK09959 847 GA-VKITTSLGHiddnhAVIKMTIMDSGSGLSQEEQQQLFKRYSQTsagrQQTGSGLGLMICKELIKNMQGDLSLESHPG 925
|
250
....*....|....*...
gi 1680491246 357 SGAVFTMSFPAHATQHVA 374
Cdd:PRK09959 926 IGTTFTITIPVEISQQVA 943
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
242-384 |
5.82e-10 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 61.11 E-value: 5.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 242 LADQAQLSVVFEGFEQ-DAALVGNLTALQGAVLNLVHNACQVSEPGT-RVTVKASMAESLLsIEVADCGPGVSDSVKDKI 319
Cdd:PRK11091 372 QAEQKGLRFDLEPLLPlPHKVITDGTRLRQILWNLISNAVKFTQQGGvTVRVRYEEGDMLT-FEVEDSGIGIPEDELDKI 450
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1680491246 320 FEPFFTTKTH-------GTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFPAHATQHVAPTTHSDGELV 384
Cdd:PRK11091 451 FAMYYQVKDShggkpatGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHAPAVAEEVEDAFDEDDMP 522
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
263-364 |
6.49e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 56.37 E-value: 6.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 263 GNLTALQGAVLNLVHNACQVSEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKT------HGTGLGLA 336
Cdd:cd16947 16 ANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDsrnsakQGNGLGLT 95
|
90 100
....*....|....*....|....*...
gi 1680491246 337 VVKSVVNAHKGQFAVANKAGSGAVFTMS 364
Cdd:cd16947 96 ITKRLAESMGGSIYVNSKPYEKTVFTVT 123
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
154-219 |
7.00e-10 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 54.52 E-value: 7.00e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1680491246 154 ALGKMVASLAHQIRTPLSAAMLYAANLTRSDLGQDATSgFAHKLTARLQELESQVNDMLLFAKSGE 219
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQRE-YLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
272-366 |
1.25e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 55.27 E-value: 1.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 272 VLNLVHNACQVSEPGT-RVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKTHG------TGLGLAVVKSVVNA 344
Cdd:cd16953 5 LRNLIGNAISFSPPDTgRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANeafgqhSGLGLSISRQIIEA 84
|
90 100
....*....|....*....|....*.
gi 1680491246 345 HKGQFAVANK----AGSGAVFTMSFP 366
Cdd:cd16953 85 HGGISVAENHnqpgQVIGARFTVQLP 110
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
152-216 |
1.96e-09 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 53.37 E-value: 1.96e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1680491246 152 LSALGKMVASLAHQIRTPLSAAMLYAANLTRSDLGQDATSGFAHKLTARLQELESQVNDMLLFAK 216
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
163-364 |
2.32e-09 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 58.51 E-value: 2.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 163 AHQIRTPLSA---------------AMLYAAnLTRSDLGQD-ATSGFAHKLT-ARLqELESQVNDMllfaksgeDQVVSN 225
Cdd:PRK10337 245 AHELRSPLAAlkvqtevaqlsdddpQARKKA-LLQLHAGIDrATRLVDQLLTlSRL-DSLDNLQDV--------AEIPLE 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 226 LTLADLKMAIAPNaitlADQAQLSVVFEGFEQDAALVGNLTALQGAVLNLVHNACQVSEPGTRVTVKASMAesllSIEVA 305
Cdd:PRK10337 315 DLLQSAVMDIYHT----AQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR----NFTVR 386
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1680491246 306 DCGPGVSDSVKDKIFEPFF----TTKThGTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMS 364
Cdd:PRK10337 387 DNGPGVTPEALARIGERFYrppgQEAT-GSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVS 448
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
138-366 |
2.79e-09 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 58.76 E-value: 2.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 138 ETRQLQARVSHMQRlsALGKMVASLAHQIRTPLSAaMLYAANLTRSDLGQDATSGFAHKLTARLQELESQVNDMLLFakS 217
Cdd:PRK11466 429 EHRQARAEAEKASQ--AKSAFLAAMSHEIRTPLYG-ILGTAQLLADNPALNAQRDDLRAITDSGESLLTILNDILDY--S 503
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 218 GEDQVVSNLTLADLKMAIAP---NAITLAD---QAQLSVVFEGFEQD--AALVGNLTALQGAVLNLVHNACQVSEPGTrV 289
Cdd:PRK11466 504 AIEAGGKNVSVSDEPFEPRPlleSTLQLMSgrvKGRPIRLATDIADDlpTALMGDPRRIRQVITNLLSNALRFTDEGS-I 582
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1680491246 290 TVKASMAESLLSIEVADCGPGVSDSVKDKIFEPF--FTTKTHGTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:PRK11466 583 VLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFvqVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
274-366 |
3.30e-09 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 58.39 E-value: 3.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 274 NLVHNACQV--SEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKTHGTGLGLAVVKSVVNAHKGQFAV 351
Cdd:PRK11086 440 NLIENALEAvgGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAV 519
|
90
....*....|....*
gi 1680491246 352 ANKAGSGAVFTMSFP 366
Cdd:PRK11086 520 ESEPGVGTQFFVQIP 534
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
268-366 |
3.91e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 53.87 E-value: 3.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 268 LQGAVLNLVHNACQVSEPGT--RVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKT----HGTGLGLAVVKSV 341
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRppRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSreeyEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|....*
gi 1680491246 342 VNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:cd16921 81 IERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
274-365 |
4.23e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 54.56 E-value: 4.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 274 NLVHNACQVSEpgTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFE--PFFTTKTHGTGLGLAVVKSVVNAHKGQFAV 351
Cdd:cd16954 44 NLLDNACKWCL--EFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQrgQRLDEQRPGQGLGLAIAKEIVEQYGGELSL 121
|
90
....*....|....
gi 1680491246 352 ANKAGSGAVFTMSF 365
Cdd:cd16954 122 SDSPLGGARFEVVF 135
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
260-382 |
5.75e-09 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 58.06 E-value: 5.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 260 ALVGNLTALQGAVLNLVHNACQVSEPGTrVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKT------HGTGL 333
Cdd:PRK10841 555 ALNGDPMRLQQVISNLLSNAIKFTDTGC-IVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTgvqrnfQGTGL 633
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1680491246 334 GLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFPAHATQhVAPTTHSDGE 382
Cdd:PRK10841 634 GLAICEKLINMMDGDISVDSEPGMGSQFTIRIPLYGAQ-YPQKKGVEGL 681
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
154-219 |
6.80e-09 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 51.80 E-value: 6.80e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1680491246 154 ALGKMVASLAHQIRTPLSAAMLYAANLTRSDLgQDATSGFAHKLTARLQELESQVNDMLLFAKSGE 219
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTEL-SEEQREYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
263-366 |
7.55e-09 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 57.23 E-value: 7.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 263 GNLTALQGAVLNLVHNACQVSepGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFftTK------THGTGLGLA 336
Cdd:PRK09467 327 MNPIAIKRALANLVVNAARYG--NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPF--TRgdsargSSGTGLGLA 402
|
90 100 110
....*....|....*....|....*....|
gi 1680491246 337 VVKSVVNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:PRK09467 403 IVKRIVDQHNGKVELGNSEEGGLSARAWLP 432
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
160-369 |
1.31e-08 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 56.57 E-value: 1.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 160 ASLAHQIRTPLsaAMLyaanltRSDLG--QDA----TSGFAHKLTARLQELESQVNDMLLFAKSGEDqvvsnlTLADLKM 233
Cdd:PRK10549 245 ADISHELRTPL--AVL------RGELEaiQDGvrkfTPESVASLQAEVGTLTKLVDDLHQLSLSDEG------ALAYRKT 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 234 AIapNAITLADQA-----------QLSVVFEgFEQDAALVGNLTALQGAVLNLVHNACQVSEPGTRVTVKASMAESLLSI 302
Cdd:PRK10549 311 PV--DLVPLLEVAggafrerfasrGLTLQLS-LPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRL 387
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1680491246 303 EVADCGPGVSDSVKDKIFEPFFTTKTH------GTGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFPAHA 369
Cdd:PRK10549 388 TFADSAPGVSDEQLQKLFERFYRTEGSrnrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLER 460
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
275-366 |
1.96e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 51.90 E-value: 1.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 275 LVHNACQVSEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTK-----THGTGLGLAVVKSVVNAHKGQF 349
Cdd:cd16948 13 IVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGEngrnfQESTGMGLYLVKKLCDKLGHKI 92
|
90
....*....|....*..
gi 1680491246 350 AVANKAGSGAVFTMSFP 366
Cdd:cd16948 93 DVESEVGEGTTFTITFP 109
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
49-112 |
3.57e-07 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 47.16 E-value: 3.57e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1680491246 49 RLSHLLQVMPAGVIVLDGYGIVRQANSQAIDLLGEPLEGELWRTIIARSFKPRADDGHEVSLID 112
Cdd:pfam13188 2 RLRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLGELLDLLDPLLEDALELLRELR 65
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
178-371 |
2.99e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 49.13 E-value: 2.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 178 ANLTRSDLGQDATSGFAHKLTARLQELeSQVNDMLLfaksgEDQVVSNLTLADLKMAIAPNAITLADQAQLSVVFEG--- 254
Cdd:COG3920 317 LRLQARRADDPEAREALEESQNRIQAL-ALVHELLY-----QSEDWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGpdv 390
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 255 -FEQDAAlvgnlTALqGAVLN-LVHNACQ---VSEPGTRVTVKASMAESLLSIEVADCGPGVSDSVkdkifepfftTKTH 329
Cdd:COG3920 391 eLPADAA-----VPL-GLILNeLVTNALKhafLSGEGGRIRVSWRREDGRLRLTVSDNGVGLPEDV----------DPPA 454
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1680491246 330 GTGLGLAVVKSVVNAHKGQFAVANkaGSGAVFTMSFPAHATQ 371
Cdd:COG3920 455 RKGLGLRLIRALVRQLGGTLELDR--PEGTRVRITFPLAELA 494
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
261-378 |
3.52e-06 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 49.08 E-value: 3.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 261 LVGNLTALQGAVLNLVHNACQVSEPGT---RVTVKASMAESL-LSIEVADCGPGVSDSVKDKIFEPF-----FTTKTHG- 330
Cdd:PRK11107 402 VIGDPLRLQQIITNLVGNAIKFTESGNidiLVELRALSNTKVqLEVQIRDTGIGISERQQSQLFQAFrqadaSISRRHGg 481
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1680491246 331 TGLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFPAHATQHVAPTTH 378
Cdd:PRK11107 482 TGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPLDLNPNPIIDGL 529
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
38-157 |
9.62e-06 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 47.46 E-value: 9.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 38 AEVTALRQQADRLSHLLQVMPAGVIVLDGYGIVRQANSQAIDLLGEPLEGELWRTI--------IARSFKPRADDGHEVS 109
Cdd:COG3829 1 AEELELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVtelipnspLLEVLKTGKPVTGVIQ 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1680491246 110 LIDGRRVKL--SITPLQNEpGQLI----VLTDLTETRQLQARVSHMQRLSALGK 157
Cdd:COG3829 81 KTGGKGKTVivTAIPIFED-GEVIgaveTFRDITELKRLERKLREEELERGLSA 133
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
42-145 |
1.18e-05 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 46.56 E-value: 1.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 42 ALRQQADRLSHLLQVMPAGVIVLDGYGIVRQANSQAIDLLG---EPLEGELWRTIIARSFKPRADD-------------- 104
Cdd:COG2202 131 ALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGyspEELLGKSLLDLLHPEDRERLLEllrrlleggresye 210
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1680491246 105 -GHEVSLIDGRRVKLSITPLQNEPGQ-----LIVLTDLTETRQLQAR 145
Cdd:COG2202 211 lELRLKDGDGRWVWVEASAVPLRDGGevigvLGIVRDITERKRAEEA 257
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
275-366 |
1.94e-05 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 46.55 E-value: 1.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 275 LVHNAC----QVSEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPfFTTKTHGTGLGLAVVKSVVNAH---KG 347
Cdd:COG2972 344 LVENAIehgiEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEE-LSSKGEGRGIGLRNVRERLKLYygeEY 422
|
90
....*....|....*....
gi 1680491246 348 QFAVANKAGSGAVFTMSFP 366
Cdd:COG2972 423 GLEIESEPGEGTTVTIRIP 441
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
231-366 |
2.05e-05 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 46.36 E-value: 2.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 231 LKMAIAPNAitladqaQLSVVFEGFEQD--AALVGNLtalqgavlnlVHNACQVS----EPGTRVTVKASMAESLLSIEV 304
Cdd:PRK15053 411 LKMVIVPGS-------QLSQLPPGLDSTefAAIVGNL----------LDNAFEASlrsdEGNKIVELFLSDEGDDVVIEV 473
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1680491246 305 ADCGPGVSDSVKDKIFEPFFTTKTHGT---GLGLAVVKSVVNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:PRK15053 474 ADQGCGVPESLRDKIFEQGVSTRADEPgehGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIP 538
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
274-359 |
6.12e-05 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 45.01 E-value: 6.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 274 NLVHNACQVS-EpgtRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKT--HGTGLGLAVVKSVVNAHKGQFA 350
Cdd:PRK10815 385 NVLDNACKYClE---FVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTlrPGQGLGLSVAREITEQYEGKIS 461
|
....*....
gi 1680491246 351 VANKAGSGA 359
Cdd:PRK10815 462 AGDSPLGGA 470
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
288-366 |
1.25e-04 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 42.18 E-value: 1.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 288 RVTVKASMAESLLSIEVADCGPGV------------------------SDSVKDKIFEPFFTTKTH-----GTGLGLAVV 338
Cdd:cd16916 71 TITLRAEHQGNQVVIEVSDDGRGIdrekirekaierglitadeaatlsDDEVLNLIFAPGFSTAEQvtdvsGRGVGMDVV 150
|
90 100
....*....|....*....|....*...
gi 1680491246 339 KSVVNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:cd16916 151 KRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
288-366 |
4.53e-04 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 42.09 E-value: 4.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 288 RVTVKASMAESLLSIEVADCGPGVS-DSVKDK-----------------------IFEPFFTTKTH-----GTGLGLAVV 338
Cdd:COG0643 310 TITLSAYHEGGRVVIEVSDDGRGLDlEKIRAKaiekglitaeeaaalsdeellelIFAPGFSTAEEvtdlsGRGVGMDVV 389
|
90 100
....*....|....*....|....*...
gi 1680491246 339 KSVVNAHKGQFAVANKAGSGAVFTMSFP 366
Cdd:COG0643 390 KTNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
57-141 |
3.27e-03 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 37.01 E-value: 3.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1680491246 57 MPAGVIVLDGYGIVRQANSQAIDLLGEPLE-------GELWRTIIARSFKP---RADDG------HEVSLIDGRR--VKL 118
Cdd:pfam08448 4 LPDALAVLDPDGRVRYANAAAAELFGLPPEellgktlAELLPPEDAARLERalrRALEGeepidfLEELLLNGEErhYEL 83
|
90 100
....*....|....*....|....*..
gi 1680491246 119 SITPLQNEPGQ----LIVLTDLTETRQ 141
Cdd:pfam08448 84 RLTPLRDPDGEvigvLVISRDITERRR 110
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
267-335 |
3.72e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 36.63 E-value: 3.72e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1680491246 267 ALQGAVLNLVHNACQVSEPGTRVTVKASMAESLLSIEVADCGPGVSDSVKDKIFEPFFTTKThGTGLGL 335
Cdd:cd16957 5 ALQVLVENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSEK-GTGTAL 72
|
|
| |
