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Conserved domains on  [gi|1663148645|gb|QCT76302|]
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6-bladed beta-propeller [Bacteroides fragilis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF5128 super family cl44435
6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown ...
 30-255 1.47e-14

6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown function. There is a highly conserved FDxxG motif which might be important.


The actual alignment was detected with superfamily member pfam17170:

Pssm-ID: 407298 [Multi-domain]  Cd Length: 321  Bit Score: 73.90  E-value: 1.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663148645  30 VIDMNEDypeKEIVLQDIAD-ISYIPLETNDEFLFD--GSVEVVTDQYVITKGHRGNdVCFFSRQGKVLNRIHRVGNGPG 106
Cdd:pfam17170  12 VIDFDED---KDVKLSSLFDsVEFIPLETTDSCLIGdiSRIKFVDDRIFVFDSNTNN-LFVFDKKGKFVRQIGAQGNGPG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663148645 107 EYKDIGSIDVNPANGELYLKEMNRQQIHVYSLDG-KFKHSFTFPEgkRMSRMCLFSPDYLIAEqESKVPDDQDANFypYL 185
Cdd:pfam17170  88 EYLQINDFIIDKSNNSIYILDFMQNKILTYDLDGySFIGEINLDL--LPSDCCQLDKGKLAFD-SSGFDDGKRSGF--YL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663148645 186 LVSTRDGHLDSLDYvqkrNILVKLIVNAENHsyayllePSLIRNGSRFYIGNPDSDTLFAMNpDRTLEPL 255
Cdd:pfam17170 163 VITDELGNIISGFF----PAEFTLGILFNSS-------VPFYEYGDNIYFYPYYSPTVYKIM-DGELKPA 220
 
Name Accession Description Interval E-value
DUF5128 pfam17170
6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown ...
 30-255 1.47e-14

6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown function. There is a highly conserved FDxxG motif which might be important.


Pssm-ID: 407298 [Multi-domain]  Cd Length: 321  Bit Score: 73.90  E-value: 1.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663148645  30 VIDMNEDypeKEIVLQDIAD-ISYIPLETNDEFLFD--GSVEVVTDQYVITKGHRGNdVCFFSRQGKVLNRIHRVGNGPG 106
Cdd:pfam17170  12 VIDFDED---KDVKLSSLFDsVEFIPLETTDSCLIGdiSRIKFVDDRIFVFDSNTNN-LFVFDKKGKFVRQIGAQGNGPG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663148645 107 EYKDIGSIDVNPANGELYLKEMNRQQIHVYSLDG-KFKHSFTFPEgkRMSRMCLFSPDYLIAEqESKVPDDQDANFypYL 185
Cdd:pfam17170  88 EYLQINDFIIDKSNNSIYILDFMQNKILTYDLDGySFIGEINLDL--LPSDCCQLDKGKLAFD-SSGFDDGKRSGF--YL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663148645 186 LVSTRDGHLDSLDYvqkrNILVKLIVNAENHsyayllePSLIRNGSRFYIGNPDSDTLFAMNpDRTLEPL 255
Cdd:pfam17170 163 VITDELGNIISGFF----PAEFTLGILFNSS-------VPFYEYGDNIYFYPYYSPTVYKIM-DGELKPA 220
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 70-152 7.98e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 46.90  E-value: 7.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663148645  70 VTDqyviTKGHRgndVCFFSRQGKVLNRIHRVGNGPGEYKDIGSIDVNPaNGELYLKEMNRQQIHVYSLDGKFKHsfTFP 149
Cdd:cd14963    24 VAD----TNNHR---VQVFDYEGKFKKSFGGPGTGPGEFKYPYGIAVDS-DGNIYVADLYNGRIQVFDPDGKFLK--YFP 93


                  ...
gi 1663148645 150 EGK 152
Cdd:cd14963    94 EKK 96
YjiK COG3204
Uncharacterized Ca-binding beta-propeller protein YjiK [General function prediction only];
109-182 4.14e-03

Uncharacterized Ca-binding beta-propeller protein YjiK [General function prediction only];


Pssm-ID: 442437 [Multi-domain]  Cd Length: 271  Bit Score: 38.80  E-value: 4.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663148645 109 KDIGSIDVNPANGELYLKEMNRQQIHVYSLDGKFKHSFTF--------PEGkrmsrMClFSPD---YLIAEqeskvPDDQ 177
Cdd:COG3204   191 KDPSALAIDPITGHLLILSDESKLLLELDRDGKVVSALSLdkgfdfpqPEG-----IA-FDPDgnlYIVSE-----PGGG 259


                  ....*
gi 1663148645 178 DANFY 182
Cdd:COG3204   260 KNLFY 264
 
Name Accession Description Interval E-value
DUF5128 pfam17170
6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown ...
 30-255 1.47e-14

6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown function. There is a highly conserved FDxxG motif which might be important.


Pssm-ID: 407298 [Multi-domain]  Cd Length: 321  Bit Score: 73.90  E-value: 1.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663148645  30 VIDMNEDypeKEIVLQDIAD-ISYIPLETNDEFLFD--GSVEVVTDQYVITKGHRGNdVCFFSRQGKVLNRIHRVGNGPG 106
Cdd:pfam17170  12 VIDFDED---KDVKLSSLFDsVEFIPLETTDSCLIGdiSRIKFVDDRIFVFDSNTNN-LFVFDKKGKFVRQIGAQGNGPG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663148645 107 EYKDIGSIDVNPANGELYLKEMNRQQIHVYSLDG-KFKHSFTFPEgkRMSRMCLFSPDYLIAEqESKVPDDQDANFypYL 185
Cdd:pfam17170  88 EYLQINDFIIDKSNNSIYILDFMQNKILTYDLDGySFIGEINLDL--LPSDCCQLDKGKLAFD-SSGFDDGKRSGF--YL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663148645 186 LVSTRDGHLDSLDYvqkrNILVKLIVNAENHsyayllePSLIRNGSRFYIGNPDSDTLFAMNpDRTLEPL 255
Cdd:pfam17170 163 VITDELGNIISGFF----PAEFTLGILFNSS-------VPFYEYGDNIYFYPYYSPTVYKIM-DGELKPA 220
DUF4934 pfam16288
Domain of unknown function (DUF4934); This family consists of uncharacterized proteins around ...
 50-142 6.07e-06

Domain of unknown function (DUF4934); This family consists of uncharacterized proteins around 400 residues in length and is mainly found in various Bacteroides species, such as Bacteroides fragilis and Bacteroides sp. The function of this family is unknown.


Pssm-ID: 435257 [Multi-domain]  Cd Length: 102  Bit Score: 44.74  E-value: 6.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663148645  50 ISYIPLETNDEFLFDG--SVEVVTDQYVITKGHRgndvCF-FSRQ-GKVLNRIHRVGNGPGEYKDIGSIdVNPANGELYL 125
Cdd:pfam16288  10 IRYIPLETTDSVLIGNnpSIKLLKDKIIVSSQKQ----CFsFNKQtGKFLCSIGHIGNDPEGYSSLNGW-LDAANGYLYF 84

                          90
                  ....*....|....*....
gi 1663148645 126 kemNRQ--QIHVYSLDGKF 142
Cdd:pfam16288  85 ---NRGpdQLVKYDTKGNF 100
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 70-152 7.98e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 46.90  E-value: 7.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663148645  70 VTDqyviTKGHRgndVCFFSRQGKVLNRIHRVGNGPGEYKDIGSIDVNPaNGELYLKEMNRQQIHVYSLDGKFKHsfTFP 149
Cdd:cd14963    24 VAD----TNNHR---VQVFDYEGKFKKSFGGPGTGPGEFKYPYGIAVDS-DGNIYVADLYNGRIQVFDPDGKFLK--YFP 93


                  ...
gi 1663148645 150 EGK 152
Cdd:cd14963    94 EKK 96
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 61-143 1.89e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 42.66  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663148645  61 FLFDGSVeVVTDqyviTKGHRgndVCFFSRQGKVLNRIHRVGNGPGEYKDIGSIDVNPaNGELYLKEMNRQQIHVYSLDG 140
Cdd:cd14963   108 AIDDGKL-YVSD----VKKHK---VIVFDLEGKLLLEFGKPGSEPGELSYPNGIAVDE-DGNIYVADSGNGRIQVFDKNG 178


                  ...
gi 1663148645 141 KFK 143
Cdd:cd14963   179 KFI 181
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 88-153 9.76e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 40.65  E-value: 9.76e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1663148645  88 FSRQGKVLNRIhrvgNGPGEYKDIGSIDVNPANGELYLKEMNRQQIHVYSLDGKFKHSFtfpeGKR 153
Cdd:cd14962    83 FDRDGKFLRAI----GAGALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDI----GKR 140
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 82-142 1.23e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 40.34  E-value: 1.23e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1663148645  82 GNDVCFFSRQGKVLNRIHRVGNGPGEYKDIGSIDVNPaNGELYLKEMNRQQIHVYSLDGKF 142
Cdd:cd14956    80 GDRIQVFTLTGELQTIGGSSGSGPGQFNAPRGVAVDA-DGNLYVADFGNQRIQKFDPDGSF 139
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 70-146 2.42e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 39.19  E-value: 2.42e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1663148645  70 VTDqyviTKGHRgndVCFFSRQGKVLNRIHRVGNGPGEYKDIGSIDVNPaNGELYLKEMNRQQIHVYSLDGKFKHSF 146
Cdd:cd14956   169 VAD----TYNDR---IQVFDNDGAFLRKWGGRGTGPGQFNYPYGIAIDP-DGNVFVADFGNNRIQKFTADGTFLTSW 237
YjiK COG3204
Uncharacterized Ca-binding beta-propeller protein YjiK [General function prediction only];
109-182 4.14e-03

Uncharacterized Ca-binding beta-propeller protein YjiK [General function prediction only];


Pssm-ID: 442437 [Multi-domain]  Cd Length: 271  Bit Score: 38.80  E-value: 4.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663148645 109 KDIGSIDVNPANGELYLKEMNRQQIHVYSLDGKFKHSFTF--------PEGkrmsrMClFSPD---YLIAEqeskvPDDQ 177
Cdd:COG3204   191 KDPSALAIDPITGHLLILSDESKLLLELDRDGKVVSALSLdkgfdfpqPEG-----IA-FDPDgnlYIVSE-----PGGG 259


                  ....*
gi 1663148645 178 DANFY 182
Cdd:COG3204   260 KNLFY 264
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 71-146 6.46e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 38.03  E-value: 6.46e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1663148645  71 TDQYVITKGHrgNDVCFFSRQGKVLNRIHRVGNGPGEYKDIGSIDVNPaNGELYLKEMNRQQIHVYSLDGKFKHSF 146
Cdd:cd14956    24 DNVYVADARN--GRIQVFDKDGTFLRRFGTTGDGPGQFGRPRGLAVDK-DGWLYVADYWGDRIQVFTLTGELQTIG 96
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 64-149 7.35e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 37.68  E-value: 7.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663148645  64 DGSVeVVTDqyviTKGHRgndVCFFSRQGKVLNRIHRVGNGPGEYKDIGSIDVNPaNGELYLKEMNRQQIHVYSLDGKFK 143
Cdd:cd05819    65 DGNL-YVAD----TGNHR---IQKFDPDGNFLASFGGSGDGDGEFNGPRGIAVDS-SGNIYVADTGNHRIQKFDPDGEFL 135


                  ....*.
gi 1663148645 144 HSFTFP 149
Cdd:cd05819   136 TTFGSG 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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