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Conserved domains on  [gi|1663042218|gb|QCT35798|]
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glucosamine-6-phosphate deaminase [Schaalia odontolytica]

Protein Classification

glucosamine-6-phosphate deaminase( domain architecture ID 10105361)

glucosamine-6-phosphate deaminase catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and an ammonium ion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 10-242 3.39e-126

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


:

Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 357.57  E-value: 3.39e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  10 DQIASLAADRILEVYRAKPNFVLGLATGSSPLKLYAELVRRYEAGQISFAQVRSYNLDEYVGLPRDHYEGYANFIHRNLV 89
Cdd:cd01399     1 EEMSEAAAELIAELIREKPPAVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFMRENLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  90 DLVDMPEGAAHGPDGWCDDLEAGAAAYDEAIKADGGIDIQVLGIGSDGHIGFNEPGGTLASRTHVGVLTEQTRRDNARFF 169
Cdd:cd01399    81 DHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQANARFF 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1663042218 170 DGDiDQVPTHCVTQGLGTIMDSRAHIFIATGEGKADAVKAMIEGGVTQRWPASILQHHPDVTVLLDEAAASKL 242
Cdd:cd01399   161 DGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
 
Name Accession Description Interval E-value
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 10-242 3.39e-126

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 357.57  E-value: 3.39e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  10 DQIASLAADRILEVYRAKPNFVLGLATGSSPLKLYAELVRRYEAGQISFAQVRSYNLDEYVGLPRDHYEGYANFIHRNLV 89
Cdd:cd01399     1 EEMSEAAAELIAELIREKPPAVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFMRENLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  90 DLVDMPEGAAHGPDGWCDDLEAGAAAYDEAIKADGGIDIQVLGIGSDGHIGFNEPGGTLASRTHVGVLTEQTRRDNARFF 169
Cdd:cd01399    81 DHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQANARFF 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1663042218 170 DGDiDQVPTHCVTQGLGTIMDSRAHIFIATGEGKADAVKAMIEGGVTQRWPASILQHHPDVTVLLDEAAASKL 242
Cdd:cd01399   161 DGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-252 3.33e-125

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 356.06  E-value: 3.33e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218   1 MRIGIFNDEDQIASLAADRILEVYRA-----KPNFVLGLATGSSPLKLYAELVRRYEAGQISFAQVRSYNLDEYVGLPRD 75
Cdd:PRK00443    1 MRLIILKTAEEVGKWAARHIANRINAflptkERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  76 HYEGYANFIHRNLVDLVDMPEGAAHGPDGWCDDLEAGAAAYDEAIKADGGIDIQVLGIGSDGHIGFNEPGGTLASRTHVG 155
Cdd:PRK00443   81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218 156 VLTEQTRRDNARFFDGDIDQVPTHCVTQGLGTIMDSRaHIFI-ATGEGKADAVKAMIEGGVTQRWPASILQHHPDVTVLL 234
Cdd:PRK00443  161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAK-EIMLlAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVL 239

                         250
                  ....*....|....*...
gi 1663042218 235 DEAAASKLELADFYKEVW 252
Cdd:PRK00443  240 DEAAASELKVKTVKYFTE 257
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-243 1.04e-116

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 334.05  E-value: 1.04e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218   1 MRIGIFNDEDQI----ASLAADRILEVYRAKPNFVLGLATGSSPLKLYAELVRRYEAGQISFAQVRSYNLDEYVGLPRDH 76
Cdd:COG0363     2 MRVIIFPDAEELaaaaAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVGLPPDH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  77 YEGYANFIHRNLVDLVDMPEGAAHGPDGWCDDLEAGAAAYDEAIKADGGIDIQVLGIGSDGHIGFNEPGGTLASRT-HVG 155
Cdd:COG0363    82 PQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSETdRVV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218 156 VLTEQTRRDNARFFDgDIDQVPTHCVTQGLGTIMDSRAHIFIATGEGKADAVKAMIEGGVTQRWPASILQHHPDVTVLLD 235
Cdd:COG0363   162 TLDESTRQANARFFG-SIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVTWFLD 240


                  ....*...
gi 1663042218 236 EAAASKLE 243
Cdd:COG0363   241 EAAASLLT 248
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-247 1.27e-99

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 291.33  E-value: 1.27e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218   1 MRIGIFNDEDQIASLAADRILEVYRA-KPN----FVLGLATGSSPLKLYAELVRRYEAGQISFAQVRSYNLDEYVGLPRD 75
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEfKPTaarpFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  76 HYEGYANFIHRNLVDLVDMPEGAAHGPDGWCDDLEAGAAAYDEAIKADGGIDIQVLGIGSDGHIGFNEPGGTLASRTHVG 155
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218 156 VLTEQTRRDNARFFDGDIDQVPTHCVTQGLGTIMDSRAHIFIATGEGKADAVKAMIEGGVTQRWPASILQHHPDVTVLLD 235
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|..
gi 1663042218 236 EAAASKLELADF 247
Cdd:TIGR00502 241 ENATQELKVKTV 252
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
8-232 5.70e-22

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 90.76  E-value: 5.70e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218   8 DEDQIASLAADRILEVYRA----KPNFVLGLATGSSPLKLYAELVRRYEAgqISFAQVRSYNLDE-YVglPRDHYEGYAN 82
Cdd:pfam01182   2 DAEALAQALAERLAEALEAalaeRGRFTLALSGGSTPKPLYELLAAAPAR--LDWSRVHVFWGDErCV--PPDDPDSNYG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  83 FIHRNLVDLVDMPEGAAHGPDGWCDDLEAGAAAYDEAIKADGG------IDIQVLGIGSDGHI--GFnePGGTLASRTHV 154
Cdd:pfam01182  78 MAREALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPdlelpvFDLVLLGMGPDGHTasLF--PGSPALEETDR 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218 155 GVLTeqtrrdnarffdgdIDQVPTHC---VTQGLGTIMDSRAHIFIATGEGKADAVKAMIEGGVTQrWPASILQHHPDVT 231
Cdd:pfam01182 156 LVVA--------------VTDSPKPPperITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPDP-LPAALVRPGAGET 220


                  .
gi 1663042218 232 V 232
Cdd:pfam01182 221 V 221
 
Name Accession Description Interval E-value
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 10-242 3.39e-126

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 357.57  E-value: 3.39e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  10 DQIASLAADRILEVYRAKPNFVLGLATGSSPLKLYAELVRRYEAGQISFAQVRSYNLDEYVGLPRDHYEGYANFIHRNLV 89
Cdd:cd01399     1 EEMSEAAAELIAELIREKPPAVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFMRENLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  90 DLVDMPEGAAHGPDGWCDDLEAGAAAYDEAIKADGGIDIQVLGIGSDGHIGFNEPGGTLASRTHVGVLTEQTRRDNARFF 169
Cdd:cd01399    81 DHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQANARFF 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1663042218 170 DGDiDQVPTHCVTQGLGTIMDSRAHIFIATGEGKADAVKAMIEGGVTQRWPASILQHHPDVTVLLDEAAASKL 242
Cdd:cd01399   161 DGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-252 3.33e-125

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 356.06  E-value: 3.33e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218   1 MRIGIFNDEDQIASLAADRILEVYRA-----KPNFVLGLATGSSPLKLYAELVRRYEAGQISFAQVRSYNLDEYVGLPRD 75
Cdd:PRK00443    1 MRLIILKTAEEVGKWAARHIANRINAflptkERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  76 HYEGYANFIHRNLVDLVDMPEGAAHGPDGWCDDLEAGAAAYDEAIKADGGIDIQVLGIGSDGHIGFNEPGGTLASRTHVG 155
Cdd:PRK00443   81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218 156 VLTEQTRRDNARFFDGDIDQVPTHCVTQGLGTIMDSRaHIFI-ATGEGKADAVKAMIEGGVTQRWPASILQHHPDVTVLL 234
Cdd:PRK00443  161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAK-EIMLlAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVL 239

                         250
                  ....*....|....*...
gi 1663042218 235 DEAAASKLELADFYKEVW 252
Cdd:PRK00443  240 DEAAASELKVKTVKYFTE 257
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-243 1.04e-116

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 334.05  E-value: 1.04e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218   1 MRIGIFNDEDQI----ASLAADRILEVYRAKPNFVLGLATGSSPLKLYAELVRRYEAGQISFAQVRSYNLDEYVGLPRDH 76
Cdd:COG0363     2 MRVIIFPDAEELaaaaAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVGLPPDH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  77 YEGYANFIHRNLVDLVDMPEGAAHGPDGWCDDLEAGAAAYDEAIKADGGIDIQVLGIGSDGHIGFNEPGGTLASRT-HVG 155
Cdd:COG0363    82 PQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSETdRVV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218 156 VLTEQTRRDNARFFDgDIDQVPTHCVTQGLGTIMDSRAHIFIATGEGKADAVKAMIEGGVTQRWPASILQHHPDVTVLLD 235
Cdd:COG0363   162 TLDESTRQANARFFG-SIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVTWFLD 240


                  ....*...
gi 1663042218 236 EAAASKLE 243
Cdd:COG0363   241 EAAASLLT 248
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-247 1.27e-99

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 291.33  E-value: 1.27e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218   1 MRIGIFNDEDQIASLAADRILEVYRA-KPN----FVLGLATGSSPLKLYAELVRRYEAGQISFAQVRSYNLDEYVGLPRD 75
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEfKPTaarpFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  76 HYEGYANFIHRNLVDLVDMPEGAAHGPDGWCDDLEAGAAAYDEAIKADGGIDIQVLGIGSDGHIGFNEPGGTLASRTHVG 155
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218 156 VLTEQTRRDNARFFDGDIDQVPTHCVTQGLGTIMDSRAHIFIATGEGKADAVKAMIEGGVTQRWPASILQHHPDVTVLLD 235
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|..
gi 1663042218 236 EAAASKLELADF 247
Cdd:TIGR00502 241 ENATQELKVKTV 252
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-242 1.29e-96

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 283.19  E-value: 1.29e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218   1 MRIGIFNDEDQIASLAA----DRILE-VYRAKPNFVLGLATGSSPLKLYAELVRRYEAGQISFAQVRSYNLDEYVGLPRD 75
Cdd:PTZ00285    1 MRIVISEDADAVADYTSnyiiKRINDfKPTSDRPFVLGLPTGSTPLPTYQELIRAYREGRVSFSNVVTFNMDEYVGLPRD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  76 HYEGYANFIHRNLVDLVDMPEGAAHGPDGWCDDLEAGAAAYDEAIKADGGIDIQVLGIGSDGHIGFNEPGGTLASRTHVG 155
Cdd:PTZ00285   81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218 156 VLTEQTRRDNARFFDGDIDQVPTHCVTQGLGTIMDSRAHIFIATGEGKADAVKAMIEGGVTQRWPASILQHHPDVTVLLD 235
Cdd:PTZ00285  161 SLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240


                  ....*..
gi 1663042218 236 EAAASKL 242
Cdd:PTZ00285  241 EDATLEL 247
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 5-242 1.07e-78

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 249.56  E-value: 1.07e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218   5 IFNDEDQIASLAADRILEVYRAKP----NFVLGLATGSSPLKLYAELVRRYEAGQISFAQVRSYNLDEYVGLPRDHYEGY 80
Cdd:PRK02122   32 IFESSEEASRAVAQEIATLIRERQaegkPCVLGLATGSSPIGVYAELIRMHREEGLSFKNVITFNLDEYYPMQPDSLQSY 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  81 ANFIHRNLVDLVDMPEGAAHGPDGWC--DDLEAGAAAYDEAIKADGGIDIQVLGIGSDGHIGFNEPGGTLASRTHVGVLT 158
Cdd:PRK02122  112 HRFMKENLFDHVDIPPENIHIPDGTIpkEEIDEYCRDYEEKIEAAGGIDFQLLGIGRTGHIGFNEPGSGRNSRTRLVTLD 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218 159 EQTRRDNARFFdGDIDQVPTHCVTQGLGTIMDSRAHIFIATGEGKADAVKAMIEGGVTQRWPASILQHHPDVTVLLDEAA 238
Cdd:PRK02122  192 HITRRDAASDF-FGEENVPRKAITMGVGTILKARRIVLLAWGEHKAPIIKRAVEGEISDEVPASYLQEHPNATFVLDLAA 270


                  ....
gi 1663042218 239 ASKL 242
Cdd:PRK02122  271 ASEL 274
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 1-235 1.82e-44

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 149.59  E-value: 1.82e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218   1 MRIGIFNDEDQIASLAADRILEVYRAKPNFVLGLATGSSPLKLYAELVRRYEAGQISFAQVRSYNLDEYVGLPRDHYEGY 80
Cdd:PRK09762    1 QTLQQVENYTALSERASEYLLAVIRSKPDAVICLATGATPLLTYHYLVEKIHQQQVDVSQLTFVKLDEWVDLPLTMPGTC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  81 ANFIHRNLVDLVDMPEGA--AHGPDgwcDDLEAGAAAYDEAIKADGGIDIQVLGIGSDGHIGFNEPGGTLASRTHVGVLT 158
Cdd:PRK09762   81 ETFLQQHIVQPLGLREDQliSFRSE---EINETECERVTNLIARKGGLDLCVLGLGKNGHLGLNEPGESLQPACHISQLD 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1663042218 159 EQTRRDNARFFDGdidQVPTHCVTQGLGTIMDSRAHIFIATGEGKADAVKAMIEGGVTQRWPASILQHHPDVTVLLD 235
Cdd:PRK09762  158 ARTQQHEMLKTAG---RPVTRGITLGLKDILNAREVLLLVTGEGKQDATERFLTAKVSTAIPASFLWLHSNFICLID 231
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
1-244 1.83e-35

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 126.40  E-value: 1.83e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218   1 MRIGIFNDEDQIASLAADRILEVYRAKPNFVLGLATGSSPLKLYAELVRRYEaGQISFAQVRSYNLDEyvgLPRDHYEGY 80
Cdd:PRK12358    1 MKIIITKDYEEMSRVAAHHLLGYMSKTKRVNLAITAGSTPKGMYEYLITLVK-GKAWYDNVHYYNFDE---IPFRGKEGE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  81 ANFIhRNLVDLVDMPegaAHGPDGWCDDLEA-GAAAYDEAIKADGGIDIQVLGIGSDGHIGFNEPGGTLASRTHVGVLTE 159
Cdd:PRK12358   77 GVTI-TNLRNLFFTP---AGIKEENIHKLTIdNYREHDQKLARDGGLDLVVLGLGADGHFCGNLPGTTHFHDETVEVPIQ 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218 160 QTRRDNARFFD--GDIDQVPTHCVTQGLGTIMDSRAHIFIATGEGKADAVKAMIEGGVTQRWPASILQHHPDVTVLLDEA 237
Cdd:PRK12358  153 GEMVDIVAHGElgGDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTEDVPASILQLHPNLTVILDEA 232


                  ....*..
gi 1663042218 238 AASKLEL 244
Cdd:PRK12358  233 AAAELAL 239
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
8-232 5.70e-22

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 90.76  E-value: 5.70e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218   8 DEDQIASLAADRILEVYRA----KPNFVLGLATGSSPLKLYAELVRRYEAgqISFAQVRSYNLDE-YVglPRDHYEGYAN 82
Cdd:pfam01182   2 DAEALAQALAERLAEALEAalaeRGRFTLALSGGSTPKPLYELLAAAPAR--LDWSRVHVFWGDErCV--PPDDPDSNYG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  83 FIHRNLVDLVDMPEGAAHGPDGWCDDLEAGAAAYDEAIKADGG------IDIQVLGIGSDGHI--GFnePGGTLASRTHV 154
Cdd:pfam01182  78 MAREALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPdlelpvFDLVLLGMGPDGHTasLF--PGSPALEETDR 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218 155 GVLTeqtrrdnarffdgdIDQVPTHC---VTQGLGTIMDSRAHIFIATGEGKADAVKAMIEGGVTQrWPASILQHHPDVT 231
Cdd:pfam01182 156 LVVA--------------VTDSPKPPperITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPDP-LPAALVRPGAGET 220


                  .
gi 1663042218 232 V 232
Cdd:pfam01182 221 V 221
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 10-234 1.01e-21

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 89.93  E-value: 1.01e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  10 DQIASLAADRIlevyRAKPNFVLGLATGSSPLKLYAELVRRYeagQISFAQVRSYNLDE-YVglPRDHYEGYANFIHRNL 88
Cdd:cd01400     9 DRIAEALAAAI----AKRGRFSLALSGGSTPKPLYELLAAAP---ALDWSKVHVFLGDErCV--PPDDPDSNYRLAREAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  89 VDLVDMPEGAAHGPDGwCDDLEAGAAAYDEAIKADGG----IDIQVLGIGSDGHIG--FnePGgtlasrtHVGVLTEQTR 162
Cdd:cd01400    80 LSHVAIPAANIHPIPT-ELGPEDAAAAYEKELRALFGgvppFDLVLLGMGPDGHTAslF--PG-------HPALLEETDR 149

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1663042218 163 RDNARFfdgDIDQVPTHCVTQGLGTIMDSRAHIFIATGEGKADAVKAMIEGGVTQRWPASILQHHPDVTVLL 234
Cdd:cd01400   150 LVVAVT---DSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRPGEVLWF 218
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 18-228 2.60e-17

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 77.01  E-value: 2.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  18 DRILEVYRAKPNFVLGLATGSSPLKLYAELVRRYEAGqiSFAQVRSYNLDEYVGLPrDHYEGYANFIHRNLVDLVDMPEG 97
Cdd:cd00458    10 DK*EKLLEEKDDMVIGLGTGSTPAYFYKLLGEKLKRG--EISDIVGFPTDERYVPL-DSDQSNFRQAKLLAFEHDIIPAS 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218  98 AAHGPDGWCDDLEAGAAAYDEAIKADGGIDIQVLGIGSDGhigfnepggtlasrthvgvlteqtrrdnarffdgdidqvp 177
Cdd:cd00458    87 NVHYVDTSLPIEKACEKYEREILDQVDAIDLAVDGAGYRA---------------------------------------- 126

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1663042218 178 thcvtqglGTIMdsrahiFIATGEGKADAVKAMIEGGVTQRWPASILQHHP 228
Cdd:cd00458   127 --------GTVI------VLVDGRKKVDYLCQNTEPGVIENGIFADIRGKE 163
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 127-247 1.49e-03

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 39.07  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1663042218 127 DIQVLGIGSDGHIGF---NEPggtlasrthvgVLTEqtrRDNARFFDGDIDQVPTHCVTQGLGTIMDSRAHIFIATGEGK 203
Cdd:PLN02360  152 DLILLGMGSDGHVASlfpNHP-----------ALEE---KDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESK 217

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1663042218 204 ADAVKAMI----EGGVTQRWPASILQHHPDVTV-LLDEAAASKLELADF 247
Cdd:PLN02360  218 ANAVHLAIddvtEGPDAPSLPARMVQPTKGKLVwFLDKPAASKLDGFQF 266
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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