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Conserved domains on  [gi|1650117246|gb|QCQ36391|]
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sodium:proton antiporter [Bacteroides fragilis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 1-397 3.71e-112

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


:

Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 351.58  E-value: 3.71e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246   1 MSQLPtLIADLALILICAGVMTLLFKKLKQPLVLGYVVAGFLASPHMPytPSVMDTANIKTWADIGVIFLLFALGLEFSF 80
Cdd:COG4651     1 MHETP-LITTIALILGLAAVLGLLAQRLRQPPIVGYLLAGVLIGPFTP--GLVADVELIEQLAEIGVILLLFGVGLEFSL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246  81 KKIVKVGGTAVIAACTIIFCMILLGVAVGMGFGWQRMDSLFLGGMIAMSSTTIIYKAFDDLGLRKKQFTGLVLSILILED 160
Cdd:COG4651    78 KDLLAVRKIALPGALLQIALTTLLGFGIALLLGWSLGESLVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVGWLIVQD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 161 ILAIVLMVMLSTMAVSNNFEGTEMLSSIGKLLFFLILWFVVGIYAIPEFLKRCRKLMSEETLLIVSLALCFGMVAIAANT 240
Cdd:COG4651   158 LAVVLMLVLLPALAGGGGGLLGTLGLTLLKVALFVALMLVVGRRVIPWLLHRVARTRSRELFLLAVLAICLGVAYLAALF 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 241 GFSAAFGAFIMGSILAETIEAESIDRLVKPVKDLFGAIFFVSVGMMVDPAMIVEYAVPIIAITLAVILGQAFFGTMGVML 320
Cdd:COG4651   238 GLSFALGAFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLFDPSFLLENPLPVLALLLIVLIGKPLIAFLIVLA 317

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1650117246 321 AGQPLKTAMQCGFSLTQIGEFAFIIASLGLSLHVTSDFLYPIVVAVSVITTFLTPYMIRVAEPASNFVDRKLPESWR 397
Cdd:COG4651   318 LGYPLRTALLVGLSLAQIGEFSFILAALGLSLGLLSEEAYQLILAVAILTIALSPYLIALADPLYARLERRPPLAAR 394
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 675-746 1.07e-15

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


:

Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 74.57  E-value: 1.07e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1650117246 675 SEMTLKQLLIDTDSAFLGKTLRESGIRDKYHCLIAGVERGGEALMTPDVNIPFEEGDVVWVVGENEDVYRLI 746
Cdd:COG0490    66 LLLAIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVVGTREQLERLE 137
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 512-661 6.21e-12

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


:

Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 63.79  E-value: 6.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 512 SVLFVMFVITRLFKASVGLMFGVALLLVILMVLSRQLKKQSILIERKFFQNLRSRDmraeylgekkPAYAGRLLSRDLHL 591
Cdd:COG0490     1 AALALLLLLIILLLLLALAALLVAIVIVGVLGLILRGLLLLELALLLLLLGELLRL----------LTRLLIELVLLLAI 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 592 TDFEIPGESAWAGKTLLELNLGKKYGVHVVSILRGKRRINIPGGSVRLFPMDKIQVIGTDDQLNTFAEEM 661
Cdd:COG0490    71 EEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVVGTREQLERLEELL 140
 
Name Accession Description Interval E-value
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 1-397 3.71e-112

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 351.58  E-value: 3.71e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246   1 MSQLPtLIADLALILICAGVMTLLFKKLKQPLVLGYVVAGFLASPHMPytPSVMDTANIKTWADIGVIFLLFALGLEFSF 80
Cdd:COG4651     1 MHETP-LITTIALILGLAAVLGLLAQRLRQPPIVGYLLAGVLIGPFTP--GLVADVELIEQLAEIGVILLLFGVGLEFSL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246  81 KKIVKVGGTAVIAACTIIFCMILLGVAVGMGFGWQRMDSLFLGGMIAMSSTTIIYKAFDDLGLRKKQFTGLVLSILILED 160
Cdd:COG4651    78 KDLLAVRKIALPGALLQIALTTLLGFGIALLLGWSLGESLVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVGWLIVQD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 161 ILAIVLMVMLSTMAVSNNFEGTEMLSSIGKLLFFLILWFVVGIYAIPEFLKRCRKLMSEETLLIVSLALCFGMVAIAANT 240
Cdd:COG4651   158 LAVVLMLVLLPALAGGGGGLLGTLGLTLLKVALFVALMLVVGRRVIPWLLHRVARTRSRELFLLAVLAICLGVAYLAALF 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 241 GFSAAFGAFIMGSILAETIEAESIDRLVKPVKDLFGAIFFVSVGMMVDPAMIVEYAVPIIAITLAVILGQAFFGTMGVML 320
Cdd:COG4651   238 GLSFALGAFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLFDPSFLLENPLPVLALLLIVLIGKPLIAFLIVLA 317

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1650117246 321 AGQPLKTAMQCGFSLTQIGEFAFIIASLGLSLHVTSDFLYPIVVAVSVITTFLTPYMIRVAEPASNFVDRKLPESWR 397
Cdd:COG4651   318 LGYPLRTALLVGLSLAQIGEFSFILAALGLSLGLLSEEAYQLILAVAILTIALSPYLIALADPLYARLERRPPLAAR 394
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 11-379 8.46e-45

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 165.12  E-value: 8.46e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246  11 LALILICAGVMTLLFKKLKQPLVLGYVVAGFLASPHMPYTPSvMDTANIKTWADIGVIFLLFALGLEFSFKKIVKVGGTA 90
Cdd:pfam00999   1 IVLLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGLIS-EVDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246  91 VIAACT-IIFCMILLGVAVG-MGFGWQRMDSLFLGGMIAMSSTTIIYKAFDDLGLRKKQFTGLVLSILILEDILAIVLMV 168
Cdd:pfam00999  80 LLLALLgVLIPFVLIGLLLYlLGLGIPLLEALLFGAILSATSPVVVLAILKELGRVPERLGTLLLGESVLNDGVAVVLLA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 169 MLSTMAVSNNFEGTemLSSIGKLLFFLILWFVVGIYAIPEFLKRCRKLM--SEETLLIVSLALCFGMVAIAANTGFSAAF 246
Cdd:pfam00999 160 VLLALAQGVGGGSD--LGWLLLIFLVVAVGGLLLGLLIGWLLRLITRFTddDRELEVLLVLLLALLAALLAEALGVSGIL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 247 GAFIMGSILAETIEAESIDRLVKPV-KDLFGAIFFVSVGMMVDPAMIVEYAVPIIAITLAVILGQAFFGTMGVM-LAGQP 324
Cdd:pfam00999 238 GAFLAGLVLSEYPFANKLSEKLEPFgYGLFNPLFFVLVGLSLDLSSLLLSVWILVLLALVAILLGRFLGVFLLLrLLGLS 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1650117246 325 LKTAMQCGFSLTQIGEFAFIIASLGLSLHVTSDFLYPIVVAVSVITTFLTPYMIR 379
Cdd:pfam00999 318 LREALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTVLVQGITLK 372
PRK10669 PRK10669
putative cation:proton antiport protein; Provisional
 7-375 1.73e-44

putative cation:proton antiport protein; Provisional


Pssm-ID: 182633 [Multi-domain]  Cd Length: 558  Bit Score: 168.74  E-value: 1.73e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246   7 LIADLALILICAGVMTLLFKKLK-QPLVlGYVVAGFLASPhmpYTPS-VMDTANIKTWADIGVIFLLFALGLEFSFKKIV 84
Cdd:PRK10669    7 LITTIVGGLVLAFILGMLANRLRiSPLV-GYLLAGVLAGP---FTPGfVADTKLAPELAELGVILLMFGVGLHFSLKDLM 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246  85 KVGGTAVIAACTIIFCMILLGVAVGMGFGWQRMDSLFLGGMIAMSSTTIIYKAFDDLGLRKKQFTGLVLSILILED---I 161
Cdd:PRK10669   83 AVKSIAIPGAIAQIAVATLLGMALSAVLGWSLMTGIVFGLCLSTASTVVLLRALEERQLIDSQRGQIAIGWLIVEDlvmV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 162 LAIVLMVMLSTMAVSNNFEGT----EMLSSIGKLLFFLILWFVVGIYAIPEFLKRCRKLMSEETLLIVSLALCFGmVAIA 237
Cdd:PRK10669  163 LTLVLLPAVAGMMEQGDVGFAtlavDLGITIGKVIAFIAIMMLVGRRLVPWILARSAATGSRELFTLSVLALALG-IAFG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 238 ANTGFSAAF--GAFIMGSILAETIEAESIDRLVKPVKDLFGAIFFVSVGMMVDPAMIVEYAVPIIAITLAVILGQAFFGT 315
Cdd:PRK10669  242 AVELFDVSFalGAFFAGMVLNESELSHRAAHDTLPLRDAFAVLFFVSVGMLFDPMILIQQPLAVLATLAIIVFGKSLAAF 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 316 MGVMLAGQPLKTAMQCGFSLTQIGEFAFIIASLGLSLHVTSDFLYPIVVAVSVITTFLTP 375
Cdd:PRK10669  322 FLVRLFGHSRRTALTIAASLAQIGEFAFILAGLGMALNLLPQAGQNLVLAGAILSIMLNP 381
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 23-288 1.60e-37

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 141.63  E-value: 1.60e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246  23 LLFKKLKQPLVLGYVVAGFLASPHMPytPSVMDTANIKTWADIGVIFLLFALGLEFSFKKIVKVGGTA-VIAACTIIFCM 101
Cdd:TIGR00932   9 PLSRRLGIPSVLGYLLAGVLIGPSGL--GLISNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRKAAfGVGVLQVLVPG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 102 ILLGVAVGMGFGWQRMDSLFLGGMIAMSSTTIIYKAFDDLGLRKKQFTGLVLSILILEDILAIVLMVMLSTMAVSNNFEG 181
Cdd:TIGR00932  87 VLLGLLLGHLLGLALGAAVVIGIILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQDIAVVPLLALLPLLATSASTEH 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 182 TEMLSSIGKLLFFLILWFVVGIYAIPEFLKRCRKLMSEETLLIVSLALCFGMVAIAANTGFSAAFGAFIMGSILAETIEA 261
Cdd:TIGR00932 167 VALALLLLKVFLAFLLLVLLGRWLLRPVLRLTAELRPSELFTAGSLLLMFGSAYFADLLGLSMALGAFLAGVVLSESEYR 246

                         250       260
                  ....*....|....*....|....*..
gi 1650117246 262 ESIDRLVKPVKDLFGAIFFVSVGMMVD 288
Cdd:TIGR00932 247 HKLESDLEPIGGVLLPLFFISVGMSVD 273
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 675-746 1.07e-15

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 74.57  E-value: 1.07e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1650117246 675 SEMTLKQLLIDTDSAFLGKTLRESGIRDKYHCLIAGVERGGEALMTPDVNIPFEEGDVVWVVGENEDVYRLI 746
Cdd:COG0490    66 LLLAIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVVGTREQLERLE 137
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 512-661 6.21e-12

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 63.79  E-value: 6.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 512 SVLFVMFVITRLFKASVGLMFGVALLLVILMVLSRQLKKQSILIERKFFQNLRSRDmraeylgekkPAYAGRLLSRDLHL 591
Cdd:COG0490     1 AALALLLLLIILLLLLALAALLVAIVIVGVLGLILRGLLLLELALLLLLLGELLRL----------LTRLLIELVLLLAI 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 592 TDFEIPGESAWAGKTLLELNLGKKYGVHVVSILRGKRRINIPGGSVRLFPMDKIQVIGTDDQLNTFAEEM 661
Cdd:COG0490    71 EEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVVGTREQLERLEELL 140
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 591-661 9.15e-11

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 58.00  E-value: 9.15e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1650117246 591 LTDFEIPGESAWAGKTLLELNLGKKYGVHVVSILRGKRRInIPGGSVRLFPMDKIQVIGTDDQLNTFAEEM 661
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGRLI-IPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 679-745 4.24e-10

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 56.08  E-value: 4.24e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1650117246 679 LKQLLIDTDSAFLGKTLRESGIRDKYHCLIAGVERGGEALMtPDVNIPFEEGDVVWVVGENEDVYRL 745
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGRLII-PSGDTVLEAGDRLLVIGTPDDLAAL 66
trkA PRK09496
Trk system potassium transporter TrkA;
589-663 1.79e-04

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 44.73  E-value: 1.79e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1650117246 589 LHLTDFEIPGESAWAGKTLLELN-LGKKYGVHVVSILRGKRRInIPGGSVRLFPMDKIQVIGTDDQLNTFAEEMSH 663
Cdd:PRK09496  152 VQLVEVKVYEGSPLVGKPLSDLReHFPDIDVRVVAIFRGGRLI-IPRGDTVIEAGDEVYFIGAREHIRAVMSEFGR 226
trkA PRK09496
Trk system potassium transporter TrkA;
665-742 3.67e-04

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 43.57  E-value: 3.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 665 SVIDWDVFEKSEMTLKQLLIDTDSAFLGKTLREsgIRDKY---HCLIAGVERGGEALMtPDVNIPFEEGDVVWVVGENED 741
Cdd:PRK09496  140 GALDVEEFADGRVQLVEVKVYEGSPLVGKPLSD--LREHFpdiDVRVVAIFRGGRLII-PRGDTVIEAGDEVYFIGAREH 216


                  .
gi 1650117246 742 V 742
Cdd:PRK09496  217 I 217
 
Name Accession Description Interval E-value
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 1-397 3.71e-112

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 351.58  E-value: 3.71e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246   1 MSQLPtLIADLALILICAGVMTLLFKKLKQPLVLGYVVAGFLASPHMPytPSVMDTANIKTWADIGVIFLLFALGLEFSF 80
Cdd:COG4651     1 MHETP-LITTIALILGLAAVLGLLAQRLRQPPIVGYLLAGVLIGPFTP--GLVADVELIEQLAEIGVILLLFGVGLEFSL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246  81 KKIVKVGGTAVIAACTIIFCMILLGVAVGMGFGWQRMDSLFLGGMIAMSSTTIIYKAFDDLGLRKKQFTGLVLSILILED 160
Cdd:COG4651    78 KDLLAVRKIALPGALLQIALTTLLGFGIALLLGWSLGESLVFGLALSLSSTVVLLKLLEDRGELDTLHGRIAVGWLIVQD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 161 ILAIVLMVMLSTMAVSNNFEGTEMLSSIGKLLFFLILWFVVGIYAIPEFLKRCRKLMSEETLLIVSLALCFGMVAIAANT 240
Cdd:COG4651   158 LAVVLMLVLLPALAGGGGGLLGTLGLTLLKVALFVALMLVVGRRVIPWLLHRVARTRSRELFLLAVLAICLGVAYLAALF 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 241 GFSAAFGAFIMGSILAETIEAESIDRLVKPVKDLFGAIFFVSVGMMVDPAMIVEYAVPIIAITLAVILGQAFFGTMGVML 320
Cdd:COG4651   238 GLSFALGAFLAGMVLAESEYSHQAAAELLPLRDAFAVLFFVSVGMLFDPSFLLENPLPVLALLLIVLIGKPLIAFLIVLA 317

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1650117246 321 AGQPLKTAMQCGFSLTQIGEFAFIIASLGLSLHVTSDFLYPIVVAVSVITTFLTPYMIRVAEPASNFVDRKLPESWR 397
Cdd:COG4651   318 LGYPLRTALLVGLSLAQIGEFSFILAALGLSLGLLSEEAYQLILAVAILTIALSPYLIALADPLYARLERRPPLAAR 394
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
 4-383 9.80e-92

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 292.05  E-value: 9.80e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246   4 LPTLIADLALILICAGVMTLLFKKLKQPLVLGYVVAGFLASPHMPytPSVMDTANIKTWADIGVIFLLFALGLEFSFKKI 83
Cdd:COG0475     2 LASLLLQLGLLLLAAVLAGLLARRLGLPSVLGYILAGILLGPSGL--GLIEDSEALELLAELGVVLLLFLIGLELDLKRL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246  84 VKVGGTAVIAACTIIFCMILLGVAVGMGFGWQRMDSLFLGGMIAMSSTTIIYKAFDDLGLRKKQFTGLVLSILILEDILA 163
Cdd:COG0475    80 RKMGRRALGIGLLQVLLPFLLGFLLALLLGLSLAAALFLGAALAATSTAIVLKVLKELGLLKTPLGQLILGVALFDDIAA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 164 IVLMVMLSTMAVSNNFeGTEMLSSIGKLLFFLILWFVVGIYAIPEFLKRCRKLMSEETLLIVSLALCFGMVAIAANTGFS 243
Cdd:COG0475   160 ILLLALVPALAGGGSV-AGSLLLALLKALLFLALLLLVGRYLLRRLFRLVARTRSRELFLLFALLLVLLAAALAELLGLS 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 244 AAFGAFIMGSILAETIEAESIDRLVKPVKDLFGAIFFVSVGMMVDPAMIVEYAVPIIAITLAVILGQAFFGTMGVMLAGQ 323
Cdd:COG0475   239 AALGAFLAGLVLAESEYRHELEEKIEPFGDLFLPLFFVSVGLSLDLSALLSNPLLALLLVLAAIVGKLLGAYLAARLFGL 318

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 324 PLKTAMQCGFSLTQIGEFAFIIASLGLSLHVTSDFLYPIVVAVSVITTFLTPYMIRVAEP 383
Cdd:COG0475   319 SRREALRIGLLLAPRGEFALVLASLGLSAGLISPELFAALVLVVLLTTLLTPLLLRLALR 378
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 11-379 8.46e-45

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 165.12  E-value: 8.46e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246  11 LALILICAGVMTLLFKKLKQPLVLGYVVAGFLASPHMPYTPSvMDTANIKTWADIGVIFLLFALGLEFSFKKIVKVGGTA 90
Cdd:pfam00999   1 IVLLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGLIS-EVDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246  91 VIAACT-IIFCMILLGVAVG-MGFGWQRMDSLFLGGMIAMSSTTIIYKAFDDLGLRKKQFTGLVLSILILEDILAIVLMV 168
Cdd:pfam00999  80 LLLALLgVLIPFVLIGLLLYlLGLGIPLLEALLFGAILSATSPVVVLAILKELGRVPERLGTLLLGESVLNDGVAVVLLA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 169 MLSTMAVSNNFEGTemLSSIGKLLFFLILWFVVGIYAIPEFLKRCRKLM--SEETLLIVSLALCFGMVAIAANTGFSAAF 246
Cdd:pfam00999 160 VLLALAQGVGGGSD--LGWLLLIFLVVAVGGLLLGLLIGWLLRLITRFTddDRELEVLLVLLLALLAALLAEALGVSGIL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 247 GAFIMGSILAETIEAESIDRLVKPV-KDLFGAIFFVSVGMMVDPAMIVEYAVPIIAITLAVILGQAFFGTMGVM-LAGQP 324
Cdd:pfam00999 238 GAFLAGLVLSEYPFANKLSEKLEPFgYGLFNPLFFVLVGLSLDLSSLLLSVWILVLLALVAILLGRFLGVFLLLrLLGLS 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1650117246 325 LKTAMQCGFSLTQIGEFAFIIASLGLSLHVTSDFLYPIVVAVSVITTFLTPYMIR 379
Cdd:pfam00999 318 LREALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTVLVQGITLK 372
PRK10669 PRK10669
putative cation:proton antiport protein; Provisional
 7-375 1.73e-44

putative cation:proton antiport protein; Provisional


Pssm-ID: 182633 [Multi-domain]  Cd Length: 558  Bit Score: 168.74  E-value: 1.73e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246   7 LIADLALILICAGVMTLLFKKLK-QPLVlGYVVAGFLASPhmpYTPS-VMDTANIKTWADIGVIFLLFALGLEFSFKKIV 84
Cdd:PRK10669    7 LITTIVGGLVLAFILGMLANRLRiSPLV-GYLLAGVLAGP---FTPGfVADTKLAPELAELGVILLMFGVGLHFSLKDLM 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246  85 KVGGTAVIAACTIIFCMILLGVAVGMGFGWQRMDSLFLGGMIAMSSTTIIYKAFDDLGLRKKQFTGLVLSILILED---I 161
Cdd:PRK10669   83 AVKSIAIPGAIAQIAVATLLGMALSAVLGWSLMTGIVFGLCLSTASTVVLLRALEERQLIDSQRGQIAIGWLIVEDlvmV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 162 LAIVLMVMLSTMAVSNNFEGT----EMLSSIGKLLFFLILWFVVGIYAIPEFLKRCRKLMSEETLLIVSLALCFGmVAIA 237
Cdd:PRK10669  163 LTLVLLPAVAGMMEQGDVGFAtlavDLGITIGKVIAFIAIMMLVGRRLVPWILARSAATGSRELFTLSVLALALG-IAFG 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 238 ANTGFSAAF--GAFIMGSILAETIEAESIDRLVKPVKDLFGAIFFVSVGMMVDPAMIVEYAVPIIAITLAVILGQAFFGT 315
Cdd:PRK10669  242 AVELFDVSFalGAFFAGMVLNESELSHRAAHDTLPLRDAFAVLFFVSVGMLFDPMILIQQPLAVLATLAIIVFGKSLAAF 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 316 MGVMLAGQPLKTAMQCGFSLTQIGEFAFIIASLGLSLHVTSDFLYPIVVAVSVITTFLTP 375
Cdd:PRK10669  322 FLVRLFGHSRRTALTIAASLAQIGEFAFILAGLGMALNLLPQAGQNLVLAGAILSIMLNP 381
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 23-288 1.60e-37

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 141.63  E-value: 1.60e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246  23 LLFKKLKQPLVLGYVVAGFLASPHMPytPSVMDTANIKTWADIGVIFLLFALGLEFSFKKIVKVGGTA-VIAACTIIFCM 101
Cdd:TIGR00932   9 PLSRRLGIPSVLGYLLAGVLIGPSGL--GLISNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRKAAfGVGVLQVLVPG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 102 ILLGVAVGMGFGWQRMDSLFLGGMIAMSSTTIIYKAFDDLGLRKKQFTGLVLSILILEDILAIVLMVMLSTMAVSNNFEG 181
Cdd:TIGR00932  87 VLLGLLLGHLLGLALGAAVVIGIILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQDIAVVPLLALLPLLATSASTEH 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 182 TEMLSSIGKLLFFLILWFVVGIYAIPEFLKRCRKLMSEETLLIVSLALCFGMVAIAANTGFSAAFGAFIMGSILAETIEA 261
Cdd:TIGR00932 167 VALALLLLKVFLAFLLLVLLGRWLLRPVLRLTAELRPSELFTAGSLLLMFGSAYFADLLGLSMALGAFLAGVVLSESEYR 246

                         250       260
                  ....*....|....*....|....*..
gi 1650117246 262 ESIDRLVKPVKDLFGAIFFVSVGMMVD 288
Cdd:TIGR00932 247 HKLESDLEPIGGVLLPLFFISVGMSVD 273
PRK03659 PRK03659
glutathione-regulated potassium-efflux system protein KefB; Provisional
 13-373 6.60e-24

glutathione-regulated potassium-efflux system protein KefB; Provisional


Pssm-ID: 179625 [Multi-domain]  Cd Length: 601  Bit Score: 107.04  E-value: 6.60e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246  13 LILICAGVMTLLFKKLKQPLVLGYVVAGFLASPHMpyTPSVMDTANIKTWADIGVIFLLFALGLEFSFKK-------IVK 85
Cdd:PRK03659   12 LFLFAAVVAVPLAQRLGIGAVLGYLLAGIAIGPWG--LGFISDVDEILHFSELGVVFLMFIIGLELNPSKlwqlrrsIFG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246  86 VGGTAVIAACTIIFCMILLgvavgMGFGWQrmdSLFLGGM-IAMSSTTIIYKAFDDLGLRKKQFTGLVLSILILEDILAI 164
Cdd:PRK03659   90 VGAAQVLLSAAVLAGLLML-----TDFSWQ---AAVVGGIgLAMSSTAMALQLMREKGMNRSESGQLGFSVLLFQDLAVI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 165 VLMVMLSTMAVSNNfEGTEMLSSIGKLLFFLILWfVVGIYAI-PEF----LKRCRKLMSEETLLIVsLALCFGMVAIaan 239
Cdd:PRK03659  162 PALALVPLLAGSAD-EHFDWMKIGMKVLAFAGML-IGGRYLLrPLFrfiaASGVREVFTAAALLLV-LGSALFMDAL--- 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 240 tGFSAAFGAFIMGSILAETIEAESIDRLVKPVKDLFGAIFFVSVGMMVDPAMIVEYAVPIIAITLAVILGQAFFGTMGVM 319
Cdd:PRK03659  236 -GLSMALGTFIAGVLLAESEYRHELEIAIEPFKGLLLGLFFISVGMALNLGVLYTHLLWVLISVVVLVAVKGLVLYLLAR 314

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1650117246 320 LAGQPLKTAMQCGFSLTQIGEFAFIIASLGLSLHVTSDFLYP---IVVAVSVITTFL 373
Cdd:PRK03659  315 LYGLRSSERMQFAGVLSQGGEFAFVLFSAASSQRLLQGDQMAlllVVVTLSMMTTPL 371
PRK03562 PRK03562
glutathione-regulated potassium-efflux system protein KefC; Provisional
 1-345 2.87e-21

glutathione-regulated potassium-efflux system protein KefC; Provisional


Pssm-ID: 235131 [Multi-domain]  Cd Length: 621  Bit Score: 98.91  E-value: 2.87e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246   1 MSQLPTLIAdlALILICAGVMTL-LFKKLKQPLVLGYVVAGFLASPHMpyTPSVMDTANIKTWADIGVIFLLFALGLEFS 79
Cdd:PRK03562    1 MMDSHTLIQ--ALIYLGAAVLIVpIAVRLGLGSVLGYLIAGCIIGPWG--LRLVTDVESILHFAEFGVVLMLFVIGLELD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246  80 FKKIVKV------GGTAVIAACTiifcMILLGVAVGMGFGWQrmdSLFLGGM-IAMSSTTIIYKAFDDLGLRKKQFTGLV 152
Cdd:PRK03562   77 PQRLWKLrrsifgGGALQMVACG----GLLGLFCMLLGLRWQ---VALLIGLgLALSSTAIAMQAMNERNLMVTQMGRSA 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 153 LSILILEDILAIVLMVMLSTMAVSN-NFEGTEMLSSIGKLLFFLILWFVVGIYAIPEFLKRCRKLMSEETLLIVSLALCF 231
Cdd:PRK03562  150 FAILLFQDIAAIPLVAMIPLLAASGaSTTLGAFALSALKVAGALALVVLGGRYVTRPALRFVARSGLREVFTAVALFLVF 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 232 GMVAIAANTGFSAAFGAFIMGSILAETIEAESIDRLVKPVKDLFGAIFFVSVGMMVDPAMIVEYAVPIIAITLavilgqA 311
Cdd:PRK03562  230 GFGLLMEEVGLSMALGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIAVGMSIDFGTLLENPLRILILLL------G 303

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1650117246 312 FFGTMGVMLA--GQPLKTAMQ----CGFSLTQIGEFAFII 345
Cdd:PRK03562  304 FLAIKIAMLWllARPLGVPRKqrrwFAVLLGQGGEFAFVV 343
PLN03159 PLN03159
cation/H(+) antiporter 15; Provisional
 4-402 4.34e-16

cation/H(+) antiporter 15; Provisional


Pssm-ID: 215608 [Multi-domain]  Cd Length: 832  Bit Score: 82.63  E-value: 4.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246   4 LPTLIADLALILICAGVMTLLFKKLKQPLVLGYVVAGFLASPHMPYTPSVMDTA--------NIKTWADIGVIFLLFALG 75
Cdd:PLN03159   41 LPLFILQLTLVVVTTRLLVFILKPFRQPRVISEILGGVILGPSVLGQSEVFANTifplrsvmVLETMANLGLLYFLFLVG 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246  76 LEFSFKKIVKVGGTAVIAACTIIFCMILLGVAVGMGFGW------QRMDSLFLGGMIAMSSTTIIYKAFDDLGLRKKQFT 149
Cdd:PLN03159  121 VEMDISVIRRTGKKALAIAIAGMALPFCIGLAFSFIFHQvsrnvhQGTFILFLGVALSVTAFPVLARILAEIKLINTELG 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 150 GLVLSILILEDILAIVLMVMLSTMAVSNNFEGTEMLSSIGKLLFFLILWFVV--GIYAIpeflkrCRKLMSEETL--LIV 225
Cdd:PLN03159  201 RIAMSAALVNDMCAWILLALAIALAENDSTSLASLWVLLSSVAFVLFCFYVVrpGIWWI------IRRTPEGETFseFYI 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 226 SLALCFGMVA--IAANTGFSAAFGAFIMGSILAE-TIEAESIDRLVKPVKDLFGAIFFVSVGMMVDPAMIVEyavPIIAI 302
Cdd:PLN03159  275 CLILTGVMISgfITDAIGTHSVFGAFVFGLVIPNgPLGVTLIEKLEDFVSGLLLPLFFAISGLKTNVTKIQG---PATWG 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 303 TLAVILGQAFFG-TMGVMLA----GQPLKTAMQCGFSLTQIGEFAFIIASLGLSLHVTSDFLYPIVVAVSVI-TTFLTPY 376
Cdd:PLN03159  352 LLVLVIIMASAGkIMGTIIIaffyTMPFREGITLGFLMNTKGLVEMIVLNVGRDQEVLDDESFAVMVLVAVAmTALITPV 431

                         410       420
                  ....*....|....*....|....*.
gi 1650117246 377 MIRVAEPASNFVDRKlpeswRRFLMR 402
Cdd:PLN03159  432 VTVVYRPARRLVGYK-----RRTIQR 452
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 675-746 1.07e-15

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 74.57  E-value: 1.07e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1650117246 675 SEMTLKQLLIDTDSAFLGKTLRESGIRDKYHCLIAGVERGGEALMTPDVNIPFEEGDVVWVVGENEDVYRLI 746
Cdd:COG0490    66 LLLAIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVVGTREQLERLE 137
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
6-308 9.03e-15

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 77.70  E-value: 9.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246   6 TLIADLALILICAGVMTLLFKKLKQPLVLGYVVAGFLASP--HMPYTPSVMDTANIktwADIGVIFLLFALGLEFSFKKI 83
Cdd:COG0025     2 ELLLLILLLLLLGLLSQWLARRLKLPAPLLLLLAGILLGPglGLELDPELGDLEPL---LELFLPPLLFEAALNLDLREL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246  84 VKVGGTAVIAAC-TIIFCMILLGVAVGMGFGWQRMDSLFLGGMIAMSSTTIIYKAFDDLGLRKKqftglVLSILILE--- 159
Cdd:COG0025    79 RRNGRPILRLAVvGVLLTTLAVALAAHWLLGLPLAAALLLGAILAPTDPVAVSPILRRLGVPKR-----LRTILEGEsll 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 160 -DILAIVLMVMLSTMAVSNNFEGTEMLSSIGKLLFFLILWFVVGIYAIPEFLKRCRKLMSEetlLIVSLALCFGMVAIAA 238
Cdd:COG0025   154 nDATALVLFVLALAAALGGGFSLGEALLDFLLAILGGILVGLLLGWLLGRLLRRLPDPLLE---ILLTLALPFLAYLLAE 230

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1650117246 239 NTGFSAAFGAFIMGSILAETIEAESIDRLVKPVKD-------LFGAIFFVSVGMMVDPAMIVEYAVPIIAITLAVIL 308
Cdd:COG0025   231 ALHGSGVLAVVVAGLVLGNAGRRSLSPETRLQLLEfwetlefLLNSLLFVLLGAQLPLILLGALGLGGILLVLLALL 307
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 512-661 6.21e-12

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 63.79  E-value: 6.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 512 SVLFVMFVITRLFKASVGLMFGVALLLVILMVLSRQLKKQSILIERKFFQNLRSRDmraeylgekkPAYAGRLLSRDLHL 591
Cdd:COG0490     1 AALALLLLLIILLLLLALAALLVAIVIVGVLGLILRGLLLLELALLLLLLGELLRL----------LTRLLIELVLLLAI 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 592 TDFEIPGESAWAGKTLLELNLGKKYGVHVVSILRGKRRINIPGGSVRLFPMDKIQVIGTDDQLNTFAEEM 661
Cdd:COG0490    71 EEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVVGTREQLERLEELL 140
COG3273 COG3273
Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];
588-662 5.20e-11

Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];


Pssm-ID: 442504 [Multi-domain]  Cd Length: 387  Bit Score: 65.07  E-value: 5.20e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1650117246 588 DLHLTDFEIPGESAWAGKTLLELNLGKKYGVHVVSILRGKRRINIPGGSVRLFPMDKIQVIGTDDQLNTFAEEMS 662
Cdd:COG3273   312 DERIVRVTVPPGSPLVGKTLGELKLETETGVRVIAIRRGGGWIYDPDGDTRLRAGDVLIVKGTREGLERLEELAG 386
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 591-661 9.15e-11

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 58.00  E-value: 9.15e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1650117246 591 LTDFEIPGESAWAGKTLLELNLGKKYGVHVVSILRGKRRInIPGGSVRLFPMDKIQVIGTDDQLNTFAEEM 661
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGRLI-IPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 679-745 4.24e-10

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 56.08  E-value: 4.24e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1650117246 679 LKQLLIDTDSAFLGKTLRESGIRDKYHCLIAGVERGGEALMtPDVNIPFEEGDVVWVVGENEDVYRL 745
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGRLII-PSGDTVLEAGDRLLVIGTPDDLAAL 66
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 558-742 8.80e-09

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 58.60  E-value: 8.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 558 KFFQNLRSRDMRAEylgEKKPAYAGRLLSRDLHLTDFEIPGESAwAGKTLLELNLGKKYGVHVVSILRGKRrINIPGGSV 637
Cdd:COG2985   174 ALLPKLFRIDLDAE---AKKLEAGEGSAYPPLVTRAYRVTNPNL-VGKTVAELEALLGTRVVISRIRRGGE-IIVPTPDT 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 638 RLFPMDKIQVIGTDDQLNTFAEEMSHVSVIDWDvfEKSEMTLKQLLIdTDSAFLGKTLRESGIRDKYHCLIAGVERGGEA 717
Cdd:COG2985   249 VLQEGDIVLVVGTREALEAAEALLGEEVDDSEL--LDSDLDVRRIVV-TNKEVAGKTLGELNLRNRFGVVITRVRRGGVE 325

                         170       180
                  ....*....|....*....|....*
gi 1650117246 718 lMTPDVNIPFEEGDVVWVVGENEDV 742
Cdd:COG2985   326 -LPATPDTVLQLGDRLTVVGPKEDV 349
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 657-733 2.58e-07

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 53.15  E-value: 2.58e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1650117246 657 FAEEMSHVSVIDWDVFEKSEMTLKQLLIDTDSAFLGKTLRESGIRDKYHCLIAGVERGGEALMtPDVNIPFEEGDVV 733
Cdd:COG0569   220 IARLLLRPGVLDVLELADGDAEIVEVTVPEGSPLVGKTLKELDLRERYGVTVVAIKRGGEVII-PSGDTVLEAGDEL 295
COG3273 COG3273
Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];
673-745 2.92e-05

Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];


Pssm-ID: 442504 [Multi-domain]  Cd Length: 387  Bit Score: 46.97  E-value: 2.92e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1650117246 673 EKSEMTLKQLLIDTDSAFLGKTLRESGIRDKYHCLIAGVERGGEALMTPDVNIPFEEGDVVWVVGENEDVYRL 745
Cdd:COG3273   309 RESDERIVRVTVPPGSPLVGKTLGELKLETETGVRVIAIRRGGGWIYDPDGDTRLRAGDVLIVKGTREGLERL 381
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 583-645 4.91e-05

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 45.83  E-value: 4.91e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1650117246 583 RLLSRDLHLTDFEIPGESAWAGKTLLELNLGKKYGVHVVSILRGKRRInIPGGSVRLFPMDKI 645
Cdd:COG0569   234 ELADGDAEIVEVTVPEGSPLVGKTLKELDLRERYGVTVVAIKRGGEVI-IPSGDTVLEAGDEL 295
trkA PRK09496
Trk system potassium transporter TrkA;
589-663 1.79e-04

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 44.73  E-value: 1.79e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1650117246 589 LHLTDFEIPGESAWAGKTLLELN-LGKKYGVHVVSILRGKRRInIPGGSVRLFPMDKIQVIGTDDQLNTFAEEMSH 663
Cdd:PRK09496  152 VQLVEVKVYEGSPLVGKPLSDLReHFPDIDVRVVAIFRGGRLI-IPRGDTVIEAGDEVYFIGAREHIRAVMSEFGR 226
trkA PRK09496
Trk system potassium transporter TrkA;
665-742 3.67e-04

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 43.57  E-value: 3.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 665 SVIDWDVFEKSEMTLKQLLIDTDSAFLGKTLREsgIRDKY---HCLIAGVERGGEALMtPDVNIPFEEGDVVWVVGENED 741
Cdd:PRK09496  140 GALDVEEFADGRVQLVEVKVYEGSPLVGKPLSD--LREHFpdiDVRVVAIFRGGRLII-PRGDTVIEAGDEVYFIGAREH 216


                  .
gi 1650117246 742 V 742
Cdd:PRK09496  217 I 217
PRK05326 PRK05326
potassium/proton antiporter;
659-741 6.09e-04

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 43.27  E-value: 6.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 659 EEMSHVSVIDWDVFEKSEMTLKQLLIDTDSAFLGKTLRESGIRDkyHCLIAGVERGGEaLMTPDVNIPFEEGDVVWVVGE 738
Cdd:PRK05326  396 PEARPVSRVELDPLEESDAELLEYRVPAGSWLVGKALRDLRLPR--GALIALIIRDGK-LLVPTGSTRLKAGDVLLVLGP 472


                  ...
gi 1650117246 739 NED 741
Cdd:PRK05326  473 ERD 475
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 686-746 7.65e-04

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 42.80  E-value: 7.65e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1650117246 686 TDSAFLGKTLRESGIRDKYHCLIAGVERGGEaLMTPDVNIPFEEGDVVWVVGENEDVYRLI 746
Cdd:COG2985   210 TNPNLVGKTVAELEALLGTRVVISRIRRGGE-IIVPTPDTVLQEGDIVLVVGTREALEAAE 269
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 586-661 1.52e-03

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 41.65  E-value: 1.52e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1650117246 586 SRDLHLTDfeipgeSAWAGKTLLELNLGKKYGVHVVSILRGKRRInIPGGSVRLFPMDKIQVIGTDDQLNTFAEEM 661
Cdd:COG2985   288 VRRIVVTN------KEVAGKTLGELNLRNRFGVVITRVRRGGVEL-PATPDTVLQLGDRLTVVGPKEDVERVAKLL 356
PRK03818 PRK03818
putative transporter; Validated
 604-742 2.63e-03

putative transporter; Validated


Pssm-ID: 179654 [Multi-domain]  Cd Length: 552  Bit Score: 41.00  E-value: 2.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1650117246 604 GKTLLELNLGKKYGVhVVSILRGKRRINIPGGSVRLFPMDKIQVIGTDDQLNT----FAEEMShvsvIDWDVFEkSEMTL 679
Cdd:PRK03818  218 GKAIKDVPILNGDKF-VCSRLKRGDTLMVPSPDTIIQLGDLLHLVGQPEDLHKaqlvIGEEVD----TSLSTRG-TDLRS 291

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1650117246 680 KQLLIdTDSAFLGKTLRESGIRDKYHCLIAGVERGG-EALMTPDVNIPFeeGDVVWVVGENEDV 742
Cdd:PRK03818  292 ERVVV-TNEKVLGKKLRDLHLKNKYGVVISRLNRAGvELVASPDLSLQF--GDILNLVGRPEAI 352
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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