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Conserved domains on  [gi|1618858058|gb|QCB92950|]
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bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase [Cellulomonas shaoxiangyii]

Protein Classification

bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase( domain architecture ID 13298246)

bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, allowing the repair of both epimers of NAD(P)HX

CATH:  3.40.1190.20|3.40.50.10260
EC:  5.1.99.6|4.2.1.136
Gene Ontology:  GO:0005524|GO:0052855|GO:0052856|GO:0052857|GO:0046496
PubMed:  21994945

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nnr2 COG0063
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport ...
 243-463 4.66e-49

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport and metabolism];


:

Pssm-ID: 439833  Cd Length: 280  Bit Score: 170.30  E-value: 4.66e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 243 AVARLETGDAADLWPVPGGSAQKYSRGVLGVVAGSGAYPGAAVLSVSGALGAGVGMVRYVG--GAGPQVLAAHPEVVV-- 318
Cdd:COG0063     1 DARLLTPADLRALLPPRPPDSHKGSRGHVLVIGGSRGYPGAAVLAARAALRAGAGLVTVAVpeSAAPAVAAALPELMVip 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 319 ---------GEGRVQAWVLGSGVAPDDETqRDRVRAALAHAvdhGEPAVADAGALDLLPE------RVPAHVVLTPHAGE 383
Cdd:COG0063    81 lpeedelleLLERADAVVIGPGLGRDEET-RELLRALLEAA---DKPLVLDADALNLLAEdpellaALPAPTVLTPHPGE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 384 LATLLrargdDVARADVEAAPLAHARRAHDLTGATVLLKGAVTVVVGPHGAVYAQGDAPAWLATAGAGDVLGGVLGAVLA 463
Cdd:COG0063   157 FARLL-----GCSVAEIQADRLEAAREAAKRYGAVVVLKGAGTVIAAPDGRVYINPTGNPGLATAGSGDVLAGIIAGLLA 231
PRK10565 super family cl32537
putative carbohydrate kinase; Provisional
 5-463 5.45e-29

putative carbohydrate kinase; Provisional


The actual alignment was detected with superfamily member PRK10565:

Pssm-ID: 182554 [Multi-domain]  Cd Length: 508  Bit Score: 120.17  E-value: 5.45e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058   5 FDPDDVRAAERPLLAA-GVPL---MDRAAFALAVHAGHVLRAVRgrvggaHVVLLVGAGNNGGDAlHAGARLARRGARVT 80
Cdd:PRK10565   18 WPADDIRRGEREAADAlGLTLyelMLRAGEAAFQVARSAYPDAR------HWLVLCGHGNNGGDG-YVVARLAQAAGIDV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058  81 ALLAAPqvhagglaaltaahgrtlrvgADGPDGDAPAGDGRAADASGGGRGGAVADLLASADVVLDGLLGIGARGGGVRG 160
Cdd:PRK10565   91 TLLAQE---------------------SDKPLPEEAALAREAWLNAGGEIHAADIVWPESVDLIVDALLGTGLRQAPREP 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 161 AGGeLVDALARVRAAgggpvVVAVDVPSGIGVADGTAAGAVVRADLTVTFGAAKPGLLLPPAAEAAGAVETVDIGLT--L 238
Cdd:PRK10565  150 YAA-LIDQANAHPAP-----VVALDIPSGLLAETGATPGAVINADHTVTFIALKPGLLTGKARDVVGQLHFDSLGLDswL 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 239 PARPA-VARLETGDAADLWPVPGGSAQKYSRGVLGVVAGSGAYPGAAVLSVSGALGAGVGMVRYV--GGAGPQVLAAHPE 315
Cdd:PRK10565  224 AGQEApIQRFDAEQLSQWLKPRRPTSHKGDHGRLLIIGGDHGTAGAIRMAGEAALRSGAGLVRVLtrSENIAPLLTARPE 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 316 VVVGEGRVQA------W----VLGSGVApddetQRDRVRAALAHAVDHGEPAVADAGALDLL---PERvPAHVVLTPHAG 382
Cdd:PRK10565  304 LMVHELTPDSleesleWadvvVIGPGLG-----QQEWGKKALQKVENFRKPMLWDADALNLLainPDK-RHNRVITPHPG 377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 383 ELATLLRARgddvaRADVEAAPLAHARRAHDLTGATVLLKGAVTVVVGPHGAVYAQGDAPAWLATAGAGDVLGGVLGAVL 462
Cdd:PRK10565  378 EAARLLGCS-----VAEIESDRLLSARRLVKRYGGVVVLKGAGTVIAAEPDALAIIDVGNAGMASGGMGDVLSGIIGALL 452


                  .
gi 1618858058 463 A 463
Cdd:PRK10565  453 G 453
 
Name Accession Description Interval E-value
Nnr2 COG0063
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport ...
 243-463 4.66e-49

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport and metabolism];


Pssm-ID: 439833  Cd Length: 280  Bit Score: 170.30  E-value: 4.66e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 243 AVARLETGDAADLWPVPGGSAQKYSRGVLGVVAGSGAYPGAAVLSVSGALGAGVGMVRYVG--GAGPQVLAAHPEVVV-- 318
Cdd:COG0063     1 DARLLTPADLRALLPPRPPDSHKGSRGHVLVIGGSRGYPGAAVLAARAALRAGAGLVTVAVpeSAAPAVAAALPELMVip 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 319 ---------GEGRVQAWVLGSGVAPDDETqRDRVRAALAHAvdhGEPAVADAGALDLLPE------RVPAHVVLTPHAGE 383
Cdd:COG0063    81 lpeedelleLLERADAVVIGPGLGRDEET-RELLRALLEAA---DKPLVLDADALNLLAEdpellaALPAPTVLTPHPGE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 384 LATLLrargdDVARADVEAAPLAHARRAHDLTGATVLLKGAVTVVVGPHGAVYAQGDAPAWLATAGAGDVLGGVLGAVLA 463
Cdd:COG0063   157 FARLL-----GCSVAEIQADRLEAAREAAKRYGAVVVLKGAGTVIAAPDGRVYINPTGNPGLATAGSGDVLAGIIAGLLA 231
YXKO-related cd01171
B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of ...
 265-463 1.46e-39

B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.


Pssm-ID: 238576  Cd Length: 254  Bit Score: 143.91  E-value: 1.46e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 265 KYSRGVLGVVAGSGAYPGAAVLSVSGALGAGVGMVRYVG--GAGPQVLAAHPEVVVGE-------------GRVQAWVLG 329
Cdd:cd01171     5 KGSRGRVLVIGGSRGYTGAAYLAALAALRAGAGLVTVATppEAAAVIKSYSPELMVHPlletdieellellERADAVVIG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 330 SGVAPDDETqrdrvRAALAHAVDHGEPAVADAGALDLLPERV-----PAHVVLTPHAGELATLLrargdDVARADVEAAP 404
Cdd:cd01171    85 PGLGRDEEA-----AEILEKALAKDKPLVLDADALNLLADEPslikrYGPVVLTPHPGEFARLL-----GALVEEIQADR 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1618858058 405 LAHARRAHDLTGATVLLKGAVTVVVGPHGAVYAQGDAPAWLATAGAGDVLGGVLGAVLA 463
Cdd:cd01171   155 LAAAREAAAKLGATVVLKGAVTVIADPDGRVYVNPTGNPGLATGGSGDVLAGIIAALLA 213
PRK10565 PRK10565
putative carbohydrate kinase; Provisional
 5-463 5.45e-29

putative carbohydrate kinase; Provisional


Pssm-ID: 182554 [Multi-domain]  Cd Length: 508  Bit Score: 120.17  E-value: 5.45e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058   5 FDPDDVRAAERPLLAA-GVPL---MDRAAFALAVHAGHVLRAVRgrvggaHVVLLVGAGNNGGDAlHAGARLARRGARVT 80
Cdd:PRK10565   18 WPADDIRRGEREAADAlGLTLyelMLRAGEAAFQVARSAYPDAR------HWLVLCGHGNNGGDG-YVVARLAQAAGIDV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058  81 ALLAAPqvhagglaaltaahgrtlrvgADGPDGDAPAGDGRAADASGGGRGGAVADLLASADVVLDGLLGIGARGGGVRG 160
Cdd:PRK10565   91 TLLAQE---------------------SDKPLPEEAALAREAWLNAGGEIHAADIVWPESVDLIVDALLGTGLRQAPREP 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 161 AGGeLVDALARVRAAgggpvVVAVDVPSGIGVADGTAAGAVVRADLTVTFGAAKPGLLLPPAAEAAGAVETVDIGLT--L 238
Cdd:PRK10565  150 YAA-LIDQANAHPAP-----VVALDIPSGLLAETGATPGAVINADHTVTFIALKPGLLTGKARDVVGQLHFDSLGLDswL 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 239 PARPA-VARLETGDAADLWPVPGGSAQKYSRGVLGVVAGSGAYPGAAVLSVSGALGAGVGMVRYV--GGAGPQVLAAHPE 315
Cdd:PRK10565  224 AGQEApIQRFDAEQLSQWLKPRRPTSHKGDHGRLLIIGGDHGTAGAIRMAGEAALRSGAGLVRVLtrSENIAPLLTARPE 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 316 VVVGEGRVQA------W----VLGSGVApddetQRDRVRAALAHAVDHGEPAVADAGALDLL---PERvPAHVVLTPHAG 382
Cdd:PRK10565  304 LMVHELTPDSleesleWadvvVIGPGLG-----QQEWGKKALQKVENFRKPMLWDADALNLLainPDK-RHNRVITPHPG 377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 383 ELATLLRARgddvaRADVEAAPLAHARRAHDLTGATVLLKGAVTVVVGPHGAVYAQGDAPAWLATAGAGDVLGGVLGAVL 462
Cdd:PRK10565  378 EAARLLGCS-----VAEIESDRLLSARRLVKRYGGVVVLKGAGTVIAAEPDALAIIDVGNAGMASGGMGDVLSGIIGALL 452


                  .
gi 1618858058 463 A 463
Cdd:PRK10565  453 G 453
Carb_kinase pfam01256
Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also ...
 271-463 2.12e-22

Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also is a carbohydrate kinase. (personal obs Yeats C).


Pssm-ID: 396007  Cd Length: 242  Bit Score: 96.28  E-value: 2.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 271 LGVVAGSGAYPGAAVLSVSGALGAGVGMVRYVG--GAGPQVLAAHPEVVV-----------GEGRVQAWVLGSGVAPDDe 337
Cdd:pfam01256   1 VLVIGGSKDYTGAPLLAALAALRSGAGLVSVATdsEAIAVLKSPLPEVMVhplpetssileKLSRYDAVVIGPGLGRDE- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 338 tqrdRVRAALAHAVDHGEPAVADAGALDLLPERVP-----AHVVLTPHAGELATLLRA---RGDDVARAdveaaplahAR 409
Cdd:pfam01256  80 ----KGKAALEEVLAKDCPLVIDADALNLLAINNEkpareGPTVLTPHPGEFERLCGLagiLGDDRLEA---------AR 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1618858058 410 RAHDLTGATVLLKGAVTVVVGPHGAVYAQGDAPAWLATAGAGDVLGGVLGAVLA 463
Cdd:pfam01256 147 ELAQKLNGTILLKGNVTVIAAPGGEVWINSTGNSALAKGGSGDVLAGLIGGLLA 200
Nnr1 COG0062
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and ...
 5-494 1.23e-21

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and metabolism];


Pssm-ID: 439832 [Multi-domain]  Cd Length: 499  Bit Score: 98.02  E-value: 1.23e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058   5 FDPDDVRAAERPLLAA-GVP---LMDRAAFALAVHAGHvlravRGRVGGAHVVLLVGAGNNGGDALHAGARLARRGARVT 80
Cdd:COG0062     4 LTAAQMRALDRAAIEAlGIPglvLMERAGRAVARAIRR-----RFPSAARRVLVLCGPGNNGGDGLVAARLLAEAGYNVT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058  81 ALLAAPQvhagglaaltaahgrtlrvgadgpdgDAPAGDGRAADASGGGRGGAVADL------LASADVVLDGLLGIGAR 154
Cdd:COG0062    79 VFLLGDP--------------------------EKLSGDAAANLERLKAAGIPILELddelpeLAEADLIVDALFGTGLS 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 155 GGGVRgaggELVDALARVRAAGGgpVVVAVDVPSGIGVADGTAAGAVVRADLTVTFGAAKPGLLLPPAAEAAGAVETVDI 234
Cdd:COG0062   133 RPLRG----PYAELIEAINASGA--PVLAVDIPSGLDADTGEVLGAAVRADLTVTFGAPKPGLLLGPGRDYCGELVVADI 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 235 GLTLPAR---PAVARLETGDAADLWPVPGGSAQKYSRGVLGVVAGSGAYPGAAVLSVSGALGAGVGMVRYVGGAGPQVLA 311
Cdd:COG0062   207 GIGIPAAaeaPAALLLLADLLALLLPPRRRSHHKGGGGGVLVIGGGGGGGGAAAAAAAAAAAAGGGLVVLAVPPAAAAAL 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 312 AHPEVVV----------GEGRVQAWVLGSGVAPDDETQRDRVRAALAHAVDHGEPAVADAGALDLLPERVPAHVVLTPHA 381
Cdd:COG0062   287 LAALPEAmalaldddeeLLLLLAAAVVVAGGGGGGGGGAGGGLLLLLLLLLLLLVLLAAALLLLLALAAALLLLLLLPPP 366

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 382 GELATLLRARGDDVARADVEAAPLAHARRAHDLTGATVLLKGAVTVVVGPHGAVYAQGDAPAWLATAGAGDVLGGVLGAV 461
Cdd:COG0062   367 LAAALLLLRLLTELLELRAAAAALLAAAAAAAAVAAAAVVAGAAGVVVVAAAGGGGGGGGGGGGGGGGGGGGGGGGGGGL 446

                         490       500       510
                  ....*....|....*....|....*....|...
gi 1618858058 462 LAGRSADAVADPTLPAALAALAALVHGRAAHAA 494
Cdd:COG0062   447 LAGAAAAAAAAAAAAAAAAAAAAAAAALAAALL 479
YjeF_N pfam03853
YjeF-related protein N-terminus; YjeF-N domain is a novel version of the Rossmann fold with a ...
 24-216 1.25e-18

YjeF-related protein N-terminus; YjeF-N domain is a novel version of the Rossmann fold with a set of catalytic residues and structural features that are different from the conventional dehydrogenases. YjeF-N domain is fused to Ribokinases in bacteria (YjeF), where they may be phosphatases, and to divergent Sm and the FDF domain in eukaryotes (Dcp3p and FLJ21128), where they may be involved in decapping and catalyze hydrolytic RNA-processing reactions.


Pssm-ID: 427546 [Multi-domain]  Cd Length: 168  Bit Score: 83.05  E-value: 1.25e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058  24 LMDRAAFALAvhagHVLRAvRGRVGGAHVVLLVGAGNNGGDALHAGARLARRGARVTALLAAPQVHAGGLAALTAAHGRT 103
Cdd:pfam03853   4 LMENAGRAAA----RVLKA-LLSPAGPKVLILCGPGNNGGDGLAAARHLANRGAKVTVLLLGPEEKLSEDARRQLDLFKK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 104 L--RVGADGPDGDAPagdgraadasgggrggavaDLLASADVVLDGLLGIGARGGGVRgaggELVDALARVRAAGGgpVV 181
Cdd:pfam03853  79 LggKIVTDNPDEDLE-------------------KLLSPVDLIIDALLGTGLSGPLRG----EYAALIEWINQSGA--PV 133

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1618858058 182 VAVDVPSGIGVADGTAAGAVVRADLTVTFGAAKPG 216
Cdd:pfam03853 134 LAVDIPSGLDADTGAVLGTAVRADHTVTFGAPKPG 168
yjeF_cterm TIGR00196
yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length ...
 263-463 1.99e-18

yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length orthologs in a number of species, all of unknown function. However, yeast YNL200C is homologous and corresponds to the N-terminal region while yeast YKL151C and B. subtilis yxkO correspond to this C-terminal region only. The present model may hit hydroxyethylthiazole kinase, an enzyme associated with thiamine biosynthesis. [Unknown function, General]


Pssm-ID: 272955  Cd Length: 270  Bit Score: 85.13  E-value: 1.99e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 263 AQKYSRGVLGVVAGSGAYPGAAVLSVSGALGAGVGMVRY--VGGAGPQVLAAHPEVVVGE------------GRVQAWVL 328
Cdd:TIGR00196  19 SHKGQYGRVLIIGGSDDYSGAPLLAALAALRAGAGLVTVaaPENVITLINSVSPELIVHRlmwkvdedeellERYDVVVI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 329 GSGVAPDDETQRdrvraALAHAVDHGEPAVADAGALDLLPERVP--AHVVLTPHAGELATLLRARGDDVARadveaapLA 406
Cdd:TIGR00196  99 GPGLGQDPSFKK-----AVEEVLELDKPVVLDADALNLLTYNQKreGEVILTPHPGEFKRLLGVNEIQGDR-------LE 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1618858058 407 HARRAHDLTGATVLLKGAVTVVVGPHGAVYAQGDAPAWLATAGAGDVLGGVLGAVLA 463
Cdd:TIGR00196 167 AAQDIAQKLQAVVVLKGAADVIAAPDGDLWINKTGNAALAKGGTGDVLAGLIGGLLA 223
yjeF_nterm TIGR00197
yjeF N-terminal region; The protein region corresponding to this model shows no clear homology ...
 7-236 2.20e-11

yjeF N-terminal region; The protein region corresponding to this model shows no clear homology to any protein of known function. This model is built on yeast protein YNL200C and the N-terminal regions of E. coli yjeF and its orthologs in various species. The C-terminal region of yjeF and its orthologs shows similarity to hydroxyethylthiazole kinase (thiM) and other enzymes involved in thiamine biosynthesis. Yeast YKL151C and B. subtilis yxkO match the yjeF C-terminal domain but lack this region. [Unknown function, General]


Pssm-ID: 272956 [Multi-domain]  Cd Length: 205  Bit Score: 63.20  E-value: 2.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058   7 PDDVRAAERPLLAAGVP---LMDRAAFALAvhaghvlRAVRGR-VGGAHVVLLVGAGNNGGDALHAGARLARRGARVTaL 82
Cdd:TIGR00197   6 PKDMAIDKENAEYLGLTldlLMENAGKAVA-------QAVLQAyPLAGHVIIFCGPGNNGGDGFVVARHLKGFGVEVF-L 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058  83 LAAPqvhagglaaltaahgrtlrvgaDGPDGDAPAGDGRAADASGGGRGGAVADL-LASADVVLDGLLGIGARGGGVRGA 161
Cdd:TIGR00197  78 LKKE----------------------KRIECTEQAEVNLKALKVGGISIDEGNLVkPEDCDVIIDAILGTGFKGKLREPF 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1618858058 162 GGeLVDALARVRAagggpVVVAVDVPSGIGVADGTAAGAVVRADLTVTFGAAKPGLLLpPAAEAAGAVETVDIGL 236
Cdd:TIGR00197 136 KT-IVESINELPA-----PIVSVDIPSGLDVDTGAIEGPAVNADLTITFHAIKPCLLS-DRADVTGELKVGGIGI 203
PRK09355 PRK09355
hydroxyethylthiazole kinase; Validated
 336-463 4.46e-04

hydroxyethylthiazole kinase; Validated


Pssm-ID: 236477 [Multi-domain]  Cd Length: 263  Bit Score: 42.09  E-value: 4.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 336 DETQRDRVRAALAHAVDHGEPAVAD---AGA--------LDLLPERVPAhvVLTPHAGELATLL----RARGDDVAraDV 400
Cdd:PRK09355   66 TEERIEAMLAAGKIANEAGKPVVLDpvgVGAtsyrtefaLELLAEVKPA--VIRGNASEIAALAgeaaETKGVDST--DG 141

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1618858058 401 EAAPLAHARRAHDLTGATVLLKGAVTVVVGPHGAVYAQGDAPaWLAT-AGAGDVLGGVLGAVLA 463
Cdd:PRK09355  142 SADAVEIAKAAAKKYGTVVVVTGEVDYITDGERVVSVHNGHP-LMTKvTGTGCLLSAVVAAFAA 204
 
Name Accession Description Interval E-value
Nnr2 COG0063
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport ...
 243-463 4.66e-49

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport and metabolism];


Pssm-ID: 439833  Cd Length: 280  Bit Score: 170.30  E-value: 4.66e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 243 AVARLETGDAADLWPVPGGSAQKYSRGVLGVVAGSGAYPGAAVLSVSGALGAGVGMVRYVG--GAGPQVLAAHPEVVV-- 318
Cdd:COG0063     1 DARLLTPADLRALLPPRPPDSHKGSRGHVLVIGGSRGYPGAAVLAARAALRAGAGLVTVAVpeSAAPAVAAALPELMVip 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 319 ---------GEGRVQAWVLGSGVAPDDETqRDRVRAALAHAvdhGEPAVADAGALDLLPE------RVPAHVVLTPHAGE 383
Cdd:COG0063    81 lpeedelleLLERADAVVIGPGLGRDEET-RELLRALLEAA---DKPLVLDADALNLLAEdpellaALPAPTVLTPHPGE 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 384 LATLLrargdDVARADVEAAPLAHARRAHDLTGATVLLKGAVTVVVGPHGAVYAQGDAPAWLATAGAGDVLGGVLGAVLA 463
Cdd:COG0063   157 FARLL-----GCSVAEIQADRLEAAREAAKRYGAVVVLKGAGTVIAAPDGRVYINPTGNPGLATAGSGDVLAGIIAGLLA 231
YXKO-related cd01171
B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of ...
 265-463 1.46e-39

B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.


Pssm-ID: 238576  Cd Length: 254  Bit Score: 143.91  E-value: 1.46e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 265 KYSRGVLGVVAGSGAYPGAAVLSVSGALGAGVGMVRYVG--GAGPQVLAAHPEVVVGE-------------GRVQAWVLG 329
Cdd:cd01171     5 KGSRGRVLVIGGSRGYTGAAYLAALAALRAGAGLVTVATppEAAAVIKSYSPELMVHPlletdieellellERADAVVIG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 330 SGVAPDDETqrdrvRAALAHAVDHGEPAVADAGALDLLPERV-----PAHVVLTPHAGELATLLrargdDVARADVEAAP 404
Cdd:cd01171    85 PGLGRDEEA-----AEILEKALAKDKPLVLDADALNLLADEPslikrYGPVVLTPHPGEFARLL-----GALVEEIQADR 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1618858058 405 LAHARRAHDLTGATVLLKGAVTVVVGPHGAVYAQGDAPAWLATAGAGDVLGGVLGAVLA 463
Cdd:cd01171   155 LAAAREAAAKLGATVVLKGAVTVIADPDGRVYVNPTGNPGLATGGSGDVLAGIIAALLA 213
PRK10565 PRK10565
putative carbohydrate kinase; Provisional
 5-463 5.45e-29

putative carbohydrate kinase; Provisional


Pssm-ID: 182554 [Multi-domain]  Cd Length: 508  Bit Score: 120.17  E-value: 5.45e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058   5 FDPDDVRAAERPLLAA-GVPL---MDRAAFALAVHAGHVLRAVRgrvggaHVVLLVGAGNNGGDAlHAGARLARRGARVT 80
Cdd:PRK10565   18 WPADDIRRGEREAADAlGLTLyelMLRAGEAAFQVARSAYPDAR------HWLVLCGHGNNGGDG-YVVARLAQAAGIDV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058  81 ALLAAPqvhagglaaltaahgrtlrvgADGPDGDAPAGDGRAADASGGGRGGAVADLLASADVVLDGLLGIGARGGGVRG 160
Cdd:PRK10565   91 TLLAQE---------------------SDKPLPEEAALAREAWLNAGGEIHAADIVWPESVDLIVDALLGTGLRQAPREP 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 161 AGGeLVDALARVRAAgggpvVVAVDVPSGIGVADGTAAGAVVRADLTVTFGAAKPGLLLPPAAEAAGAVETVDIGLT--L 238
Cdd:PRK10565  150 YAA-LIDQANAHPAP-----VVALDIPSGLLAETGATPGAVINADHTVTFIALKPGLLTGKARDVVGQLHFDSLGLDswL 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 239 PARPA-VARLETGDAADLWPVPGGSAQKYSRGVLGVVAGSGAYPGAAVLSVSGALGAGVGMVRYV--GGAGPQVLAAHPE 315
Cdd:PRK10565  224 AGQEApIQRFDAEQLSQWLKPRRPTSHKGDHGRLLIIGGDHGTAGAIRMAGEAALRSGAGLVRVLtrSENIAPLLTARPE 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 316 VVVGEGRVQA------W----VLGSGVApddetQRDRVRAALAHAVDHGEPAVADAGALDLL---PERvPAHVVLTPHAG 382
Cdd:PRK10565  304 LMVHELTPDSleesleWadvvVIGPGLG-----QQEWGKKALQKVENFRKPMLWDADALNLLainPDK-RHNRVITPHPG 377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 383 ELATLLRARgddvaRADVEAAPLAHARRAHDLTGATVLLKGAVTVVVGPHGAVYAQGDAPAWLATAGAGDVLGGVLGAVL 462
Cdd:PRK10565  378 EAARLLGCS-----VAEIESDRLLSARRLVKRYGGVVVLKGAGTVIAAEPDALAIIDVGNAGMASGGMGDVLSGIIGALL 452


                  .
gi 1618858058 463 A 463
Cdd:PRK10565  453 G 453
Carb_kinase pfam01256
Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also ...
 271-463 2.12e-22

Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also is a carbohydrate kinase. (personal obs Yeats C).


Pssm-ID: 396007  Cd Length: 242  Bit Score: 96.28  E-value: 2.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 271 LGVVAGSGAYPGAAVLSVSGALGAGVGMVRYVG--GAGPQVLAAHPEVVV-----------GEGRVQAWVLGSGVAPDDe 337
Cdd:pfam01256   1 VLVIGGSKDYTGAPLLAALAALRSGAGLVSVATdsEAIAVLKSPLPEVMVhplpetssileKLSRYDAVVIGPGLGRDE- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 338 tqrdRVRAALAHAVDHGEPAVADAGALDLLPERVP-----AHVVLTPHAGELATLLRA---RGDDVARAdveaaplahAR 409
Cdd:pfam01256  80 ----KGKAALEEVLAKDCPLVIDADALNLLAINNEkpareGPTVLTPHPGEFERLCGLagiLGDDRLEA---------AR 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1618858058 410 RAHDLTGATVLLKGAVTVVVGPHGAVYAQGDAPAWLATAGAGDVLGGVLGAVLA 463
Cdd:pfam01256 147 ELAQKLNGTILLKGNVTVIAAPGGEVWINSTGNSALAKGGSGDVLAGLIGGLLA 200
Nnr1 COG0062
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and ...
 5-494 1.23e-21

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and metabolism];


Pssm-ID: 439832 [Multi-domain]  Cd Length: 499  Bit Score: 98.02  E-value: 1.23e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058   5 FDPDDVRAAERPLLAA-GVP---LMDRAAFALAVHAGHvlravRGRVGGAHVVLLVGAGNNGGDALHAGARLARRGARVT 80
Cdd:COG0062     4 LTAAQMRALDRAAIEAlGIPglvLMERAGRAVARAIRR-----RFPSAARRVLVLCGPGNNGGDGLVAARLLAEAGYNVT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058  81 ALLAAPQvhagglaaltaahgrtlrvgadgpdgDAPAGDGRAADASGGGRGGAVADL------LASADVVLDGLLGIGAR 154
Cdd:COG0062    79 VFLLGDP--------------------------EKLSGDAAANLERLKAAGIPILELddelpeLAEADLIVDALFGTGLS 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 155 GGGVRgaggELVDALARVRAAGGgpVVVAVDVPSGIGVADGTAAGAVVRADLTVTFGAAKPGLLLPPAAEAAGAVETVDI 234
Cdd:COG0062   133 RPLRG----PYAELIEAINASGA--PVLAVDIPSGLDADTGEVLGAAVRADLTVTFGAPKPGLLLGPGRDYCGELVVADI 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 235 GLTLPAR---PAVARLETGDAADLWPVPGGSAQKYSRGVLGVVAGSGAYPGAAVLSVSGALGAGVGMVRYVGGAGPQVLA 311
Cdd:COG0062   207 GIGIPAAaeaPAALLLLADLLALLLPPRRRSHHKGGGGGVLVIGGGGGGGGAAAAAAAAAAAAGGGLVVLAVPPAAAAAL 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 312 AHPEVVV----------GEGRVQAWVLGSGVAPDDETQRDRVRAALAHAVDHGEPAVADAGALDLLPERVPAHVVLTPHA 381
Cdd:COG0062   287 LAALPEAmalaldddeeLLLLLAAAVVVAGGGGGGGGGAGGGLLLLLLLLLLLLVLLAAALLLLLALAAALLLLLLLPPP 366

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 382 GELATLLRARGDDVARADVEAAPLAHARRAHDLTGATVLLKGAVTVVVGPHGAVYAQGDAPAWLATAGAGDVLGGVLGAV 461
Cdd:COG0062   367 LAAALLLLRLLTELLELRAAAAALLAAAAAAAAVAAAAVVAGAAGVVVVAAAGGGGGGGGGGGGGGGGGGGGGGGGGGGL 446

                         490       500       510
                  ....*....|....*....|....*....|...
gi 1618858058 462 LAGRSADAVADPTLPAALAALAALVHGRAAHAA 494
Cdd:COG0062   447 LAGAAAAAAAAAAAAAAAAAAAAAAAALAAALL 479
YjeF_N pfam03853
YjeF-related protein N-terminus; YjeF-N domain is a novel version of the Rossmann fold with a ...
 24-216 1.25e-18

YjeF-related protein N-terminus; YjeF-N domain is a novel version of the Rossmann fold with a set of catalytic residues and structural features that are different from the conventional dehydrogenases. YjeF-N domain is fused to Ribokinases in bacteria (YjeF), where they may be phosphatases, and to divergent Sm and the FDF domain in eukaryotes (Dcp3p and FLJ21128), where they may be involved in decapping and catalyze hydrolytic RNA-processing reactions.


Pssm-ID: 427546 [Multi-domain]  Cd Length: 168  Bit Score: 83.05  E-value: 1.25e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058  24 LMDRAAFALAvhagHVLRAvRGRVGGAHVVLLVGAGNNGGDALHAGARLARRGARVTALLAAPQVHAGGLAALTAAHGRT 103
Cdd:pfam03853   4 LMENAGRAAA----RVLKA-LLSPAGPKVLILCGPGNNGGDGLAAARHLANRGAKVTVLLLGPEEKLSEDARRQLDLFKK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 104 L--RVGADGPDGDAPagdgraadasgggrggavaDLLASADVVLDGLLGIGARGGGVRgaggELVDALARVRAAGGgpVV 181
Cdd:pfam03853  79 LggKIVTDNPDEDLE-------------------KLLSPVDLIIDALLGTGLSGPLRG----EYAALIEWINQSGA--PV 133

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1618858058 182 VAVDVPSGIGVADGTAAGAVVRADLTVTFGAAKPG 216
Cdd:pfam03853 134 LAVDIPSGLDADTGAVLGTAVRADHTVTFGAPKPG 168
yjeF_cterm TIGR00196
yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length ...
 263-463 1.99e-18

yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length orthologs in a number of species, all of unknown function. However, yeast YNL200C is homologous and corresponds to the N-terminal region while yeast YKL151C and B. subtilis yxkO correspond to this C-terminal region only. The present model may hit hydroxyethylthiazole kinase, an enzyme associated with thiamine biosynthesis. [Unknown function, General]


Pssm-ID: 272955  Cd Length: 270  Bit Score: 85.13  E-value: 1.99e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 263 AQKYSRGVLGVVAGSGAYPGAAVLSVSGALGAGVGMVRY--VGGAGPQVLAAHPEVVVGE------------GRVQAWVL 328
Cdd:TIGR00196  19 SHKGQYGRVLIIGGSDDYSGAPLLAALAALRAGAGLVTVaaPENVITLINSVSPELIVHRlmwkvdedeellERYDVVVI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 329 GSGVAPDDETQRdrvraALAHAVDHGEPAVADAGALDLLPERVP--AHVVLTPHAGELATLLRARGDDVARadveaapLA 406
Cdd:TIGR00196  99 GPGLGQDPSFKK-----AVEEVLELDKPVVLDADALNLLTYNQKreGEVILTPHPGEFKRLLGVNEIQGDR-------LE 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1618858058 407 HARRAHDLTGATVLLKGAVTVVVGPHGAVYAQGDAPAWLATAGAGDVLGGVLGAVLA 463
Cdd:TIGR00196 167 AAQDIAQKLQAVVVLKGAADVIAAPDGDLWINKTGNAALAKGGTGDVLAGLIGGLLA 223
yjeF_nterm TIGR00197
yjeF N-terminal region; The protein region corresponding to this model shows no clear homology ...
 7-236 2.20e-11

yjeF N-terminal region; The protein region corresponding to this model shows no clear homology to any protein of known function. This model is built on yeast protein YNL200C and the N-terminal regions of E. coli yjeF and its orthologs in various species. The C-terminal region of yjeF and its orthologs shows similarity to hydroxyethylthiazole kinase (thiM) and other enzymes involved in thiamine biosynthesis. Yeast YKL151C and B. subtilis yxkO match the yjeF C-terminal domain but lack this region. [Unknown function, General]


Pssm-ID: 272956 [Multi-domain]  Cd Length: 205  Bit Score: 63.20  E-value: 2.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058   7 PDDVRAAERPLLAAGVP---LMDRAAFALAvhaghvlRAVRGR-VGGAHVVLLVGAGNNGGDALHAGARLARRGARVTaL 82
Cdd:TIGR00197   6 PKDMAIDKENAEYLGLTldlLMENAGKAVA-------QAVLQAyPLAGHVIIFCGPGNNGGDGFVVARHLKGFGVEVF-L 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058  83 LAAPqvhagglaaltaahgrtlrvgaDGPDGDAPAGDGRAADASGGGRGGAVADL-LASADVVLDGLLGIGARGGGVRGA 161
Cdd:TIGR00197  78 LKKE----------------------KRIECTEQAEVNLKALKVGGISIDEGNLVkPEDCDVIIDAILGTGFKGKLREPF 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1618858058 162 GGeLVDALARVRAagggpVVVAVDVPSGIGVADGTAAGAVVRADLTVTFGAAKPGLLLpPAAEAAGAVETVDIGL 236
Cdd:TIGR00197 136 KT-IVESINELPA-----PIVSVDIPSGLDVDTGAIEGPAVNADLTITFHAIKPCLLS-DRADVTGELKVGGIGI 203
EntF COG1020
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ...
 80-494 2.93e-04

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440643 [Multi-domain]  Cd Length: 1329  Bit Score: 43.69  E-value: 2.93e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058   80 TALLAAPQVHAGGLAALTAAHGRTLRVGADGPDGDAPAGDGRAADAsggGRGGAVADLLASADVVLDGLL---------- 149
Cdd:COG1020    890 AALLQHPGVREAVVVAREDAPGDKRLVAYVVPEAGAAAAAALLRLA---LALLLPPYMVPAAVVLLLPLPltgngkldrl 966

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058  150 -----GIGARGGGVRGAGGELVDALARVRAAGGGPVVVAVDVPSGIGVADGTAAGAVVRADLTVTFGAAKPGLLLPPAAE 224
Cdd:COG1020    967 alpapAAAAAAAAAAPPAEEEEEEAALALLLLLVVVVGDDDFFFFGGGLGLLLLLALARAARLLLLLLLLLLLFLAAAAA 1046

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058  225 AAGAVETVDIGLTLPARPAVARLETGDAADLWPVPGGSAQKYSRGVLGVVAGSGAYPGAAVLSVSGALGAGVGMVRYVGG 304
Cdd:COG1020   1047 AAAAAAAAAAAAAAAPLAAAAAPLPLPPLLLSLLALLLALLLLLALLALLALLLLLLLLLLLLALLLLLALLLALLAALR 1126

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058  305 AGPQVLAAHPEVVVGEGRVQAWVLGSGVAPDDETQRDRVRAALAHAVDHGEPAVADAGALDLLPERVPAHVVLTPHAGEL 384
Cdd:COG1020   1127 ARRAVRQEGPRLRLLVALAAALALAALLALLLAAAAAAAELLAAAALLLLLALLLLALLLLLLLLLLLLLLLLLLLLLLL 1206

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058  385 atLLRARGDDVARADVEAAPLAHARRAHDLTGATVLLKGAVTVVVGPHGAVYAQGDAPAWLATAGAGDVLGGVLGAVLAG 464
Cdd:COG1020   1207 --LLLLLLLLLLLLLLLLLLAAAAAALLALALLLALLALAALLALAALAALAAALLALALALLALALLLLALALLLPALA 1284

                          410       420       430
                   ....*....|....*....|....*....|
gi 1618858058  465 RSADAVADPTLPAALAALAALVHGRAAHAA 494
Cdd:COG1020   1285 RARAARTARALALLLLLALLLLLALALALL 1314
PRK09355 PRK09355
hydroxyethylthiazole kinase; Validated
 336-463 4.46e-04

hydroxyethylthiazole kinase; Validated


Pssm-ID: 236477 [Multi-domain]  Cd Length: 263  Bit Score: 42.09  E-value: 4.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 336 DETQRDRVRAALAHAVDHGEPAVAD---AGA--------LDLLPERVPAhvVLTPHAGELATLL----RARGDDVAraDV 400
Cdd:PRK09355   66 TEERIEAMLAAGKIANEAGKPVVLDpvgVGAtsyrtefaLELLAEVKPA--VIRGNASEIAALAgeaaETKGVDST--DG 141

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1618858058 401 EAAPLAHARRAHDLTGATVLLKGAVTVVVGPHGAVYAQGDAPaWLAT-AGAGDVLGGVLGAVLA 463
Cdd:PRK09355  142 SADAVEIAKAAAKKYGTVVVVTGEVDYITDGERVVSVHNGHP-LMTKvTGTGCLLSAVVAAFAA 204
PLN03049 PLN03049
pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional
 24-214 7.52e-04

pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional


Pssm-ID: 215550 [Multi-domain]  Cd Length: 462  Bit Score: 42.14  E-value: 7.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058  24 LMDRAAFALAVHAGHVLRAVRGRvggaHVVLLVGAGNNGGDALHAGARLARRGARVTalLAAPQVHAGGLAALTAAHGRT 103
Cdd:PLN03049   38 LMELAGLSVASAIAEVYSPSEYR----RVLALCGPGNNGGDGLVAARHLHHFGYKPS--ICYPKRTDKPLYNGLVTQLES 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 104 LRVGADGPDgDAPAgdgraadasgggrggavaDLLASADVVLDGLLGIGARGGGVRGaggelVDALAR-VRAAGGGPVVV 182
Cdd:PLN03049  112 LSVPFLSVE-DLPS------------------DLSSQFDIVVDAMFGFSFHGAPRPP-----FDDLIQkLVRAAGPPPIV 167

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1618858058 183 AVDVPSGIGVADGTAAGAVVRADLTVTFGAAK 214
Cdd:PLN03049  168 SVDIPSGWHVEEGDVNGEGLKPDMLVSLTAPK 199
COG3903 COG3903
Predicted ATPase [General function prediction only];
27-417 2.14e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443109 [Multi-domain]  Cd Length: 933  Bit Score: 40.77  E-value: 2.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058  27 RAAFALAVHAGHVLRAVRGRVGGAHVVLLVGAGNNGGD----ALHAGARLARRGARVTALLAAPQVHAGGLAALTAAHGR 102
Cdd:COG3903   529 RAALRWALAHGDAELALRLAAALAPFWFLRGLLREGRRwlerALAAAGEAAAALAAAAALAAAAAAARAAAAAAAAAAAA 608

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 103 TLRVGADGPDGDAPAGDGRAADASGGGRGGAVADLLASADVVLDGLLGIGARGGGVRGAGGELVDALARVRAAGGGPVVV 182
Cdd:COG3903   609 AAAAAAAAAAAAAALLLLAALAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAAAAAAAAAAAAAAAALA 688

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 183 AVDVPSGIGVADGTAAGAVVRADLTVTFGAAKPGLLLPPAAEAAGAVETVDIGLTLPARPAVARLETGDAADLWPVPGGS 262
Cdd:COG3903   689 AAAAALAAAAAAAALAAAAAAALAAAAAAAAAAAAAAALLAAAAAAALAAAAAAAALALAAAAAAAAAAAAAAALAAAAA 768

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 263 AQKYSRGVLGVVAGSGAYPGAAVLSVSGALGAGVGMVRYVGGAGPQVLAAHPEVVVGEGRVQAWVLGSGVAPDDETQRDR 342
Cdd:COG3903   769 AAALAALLLALAAAAAALAAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAAAAAAAAALAAALAAAAAAAAAAAAAA 848

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1618858058 343 VRAALAHAVDHGEPAVADAGALDLLPERVPAHVVLTPHAGELATLLRARGDDVARADVEAAPLAHARRAHDLTGA 417
Cdd:COG3903   849 AAAAALAAALAAAAAAAAAAALAAAAAAAAAAAAALLAAAAAAAAAAAAAAAAAAALAAAAAAAAAAALAAAAAA 923
COG3903 COG3903
Predicted ATPase [General function prediction only];
73-467 5.46e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443109 [Multi-domain]  Cd Length: 933  Bit Score: 39.62  E-value: 5.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058  73 ARRGARVTALLAAPQVHAGGLAALTAAHGRTLRvgADGPDGDAPAGDGRAADASGGGRGGAVADLLASADVVLDGLLGIG 152
Cdd:COG3903   541 AELALRLAAALAPFWFLRGLLREGRRWLERALA--AAGEAAAALAAAAALAAAAAAARAAAAAAAAAAAAAAAAAAAAAA 618

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 153 ARGGGVRGAGGELVDALARVRAAGGGPVVVAVDVPSGIGVADGTAAGAVVRADLTVTFGAAKPGLLLPPAAEAAGAVETV 232
Cdd:COG3903   619 AAAALLLLAALAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAAAAAAAAAAAAAAAALAAAAAALAAAA 698

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 233 DIGLTLPARPAVARLETGDAADLWPVPGGSAQKYSRGVLGVVAGSGAYPGAAVLSVSGALGAGVGMVRYVGGAGPQVLAA 312
Cdd:COG3903   699 AAAALAAAAAAALAAAAAAAAAAAAAAALLAAAAAAALAAAAAAAALALAAAAAAAAAAAAAAALAAAAAAAALAALLLA 778

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 313 HPEVVVGEGRVQAWVLGSGVAPDDETQRDRVRAALAHAVDHGEPAVADAGALDLLPERVPAHVVLTPHAGELATLLRARG 392
Cdd:COG3903   779 LAAAAAALAAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAAAAAAAAALAAALAAAAAAAAAAAAAAAAAAALAAAL 858

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1618858058 393 DDVARADVEAAPLAHARRAHDLTGATVLLKGAVTVVVGPHGAVYAQGDAPAWLATAGAGDVLGGVLGAVLAGRSA 467
Cdd:COG3903   859 AAAAAAAAAAALAAAAAAAAAAAAALLAAAAAAAAAAAAAAAAAAALAAAAAAAAAAALAAAAAAAAAAAAAAAA 933
PLN03050 PLN03050
pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional
 51-216 9.46e-03

pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional


Pssm-ID: 215551 [Multi-domain]  Cd Length: 246  Bit Score: 37.93  E-value: 9.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058  51 HVVLLVGAGNNGGDALHAGARLARRGARVTALLaaPQVHAGGLAALTAAHGRTLrvgadgpdgdapagdGRAADASGGGR 130
Cdd:PLN03050   62 RVLLVCGPGNNGGDGLVAARHLAHFGYEVTVCY--PKQSSKPHYENLVTQCEDL---------------GIPFVQAIGGT 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618858058 131 GGAVADLLASADVVLDGLLGIGARGGGVRGAGGeLVDALARVRAAGggPVVVAVDVPSGIGVADGTAAGAVVRADLTVTF 210
Cdd:PLN03050  125 NDSSKPLETTYDVIVDAIFGFSFHGAPRAPFDT-LLAQMVQQQKSP--PPIVSVDVPSGWDVDEGDVSGTGMRPDVLVSL 201


                  ....*.
gi 1618858058 211 GAAKPG 216
Cdd:PLN03050  202 TAPKLS 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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