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Conserved domains on  [gi|1608354812|gb|QBX55874|]
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hypothetical protein EXE58_10660 [Nocardioides seonyuensis]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 87-215 4.43e-07

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member pfam04230:

Pssm-ID: 471961  Cd Length: 233  Bit Score: 49.94  E-value: 4.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608354812  87 PSVIWGSGLRYNSRPVGH--------APTLLAVRGALTREV---YGESADLPL-GDPGLLARALYKSRSPRSKVILLPHF 154
Cdd:pfam04230  94 PVILLGQGIGPFLNEALRkllkkilsKADLISVRDELSYELlekLGIKENVELvPDPAFLLDKLPPKEIKKKPKKDYISI 173

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1608354812 155 SAFGTVSGRQSIQAGAAKGMHVlpptlavDDVCQAIADARLVITSSLHGLIVGHATRTPTI 215
Cdd:pfam04230 174 AKSSKKDLEDLNEKLALLYDLP-------EELLSLISQADFVITTRLHGLILALLFGVPFI 227
 
Name Accession Description Interval E-value
PS_pyruv_trans pfam04230
Polysaccharide pyruvyl transferase; Pyruvyl-transferases involved in peptidoglycan-associated ...
 87-215 4.43e-07

Polysaccharide pyruvyl transferase; Pyruvyl-transferases involved in peptidoglycan-associated polymer biosynthesis. CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides. WcaK and AmsJ are involved in the biosynthesis of colanic acid in Escherichia coli and of amylovoran in Erwinia amylovora.


Pssm-ID: 427804  Cd Length: 233  Bit Score: 49.94  E-value: 4.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608354812  87 PSVIWGSGLRYNSRPVGH--------APTLLAVRGALTREV---YGESADLPL-GDPGLLARALYKSRSPRSKVILLPHF 154
Cdd:pfam04230  94 PVILLGQGIGPFLNEALRkllkkilsKADLISVRDELSYELlekLGIKENVELvPDPAFLLDKLPPKEIKKKPKKDYISI 173

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1608354812 155 SAFGTVSGRQSIQAGAAKGMHVlpptlavDDVCQAIADARLVITSSLHGLIVGHATRTPTI 215
Cdd:pfam04230 174 AKSSKKDLEDLNEKLALLYDLP-------EELLSLISQADFVITTRLHGLILALLFGVPFI 227
WcaK COG2327
Polysaccharide pyruvyl transferase family protein WcaK (colanic acid biosynthesis) [Cell wall ...
 147-233 8.81e-04

Polysaccharide pyruvyl transferase family protein WcaK (colanic acid biosynthesis) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441900 [Multi-domain]  Cd Length: 357  Bit Score: 40.42  E-value: 8.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608354812 147 KVILLPH-FSAFGTVSGRQSIQAGAAKGMHVLPPTLAVDDVCQAIADARLVITSSLHGLIVGHATRTPTILCTFghtqep 225
Cdd:COG2327   215 KVVLLPHqYGQEDDLAIAEELAAKLKERVVVLDEELDPDELLSLIARADLVIGMRLHALIFALSAGVPVIALSY------ 288


                  ....*...
gi 1608354812 226 DFKYFDYM 233
Cdd:COG2327   289 DPKVRGLM 296
 
Name Accession Description Interval E-value
PS_pyruv_trans pfam04230
Polysaccharide pyruvyl transferase; Pyruvyl-transferases involved in peptidoglycan-associated ...
 87-215 4.43e-07

Polysaccharide pyruvyl transferase; Pyruvyl-transferases involved in peptidoglycan-associated polymer biosynthesis. CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides. WcaK and AmsJ are involved in the biosynthesis of colanic acid in Escherichia coli and of amylovoran in Erwinia amylovora.


Pssm-ID: 427804  Cd Length: 233  Bit Score: 49.94  E-value: 4.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608354812  87 PSVIWGSGLRYNSRPVGH--------APTLLAVRGALTREV---YGESADLPL-GDPGLLARALYKSRSPRSKVILLPHF 154
Cdd:pfam04230  94 PVILLGQGIGPFLNEALRkllkkilsKADLISVRDELSYELlekLGIKENVELvPDPAFLLDKLPPKEIKKKPKKDYISI 173

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1608354812 155 SAFGTVSGRQSIQAGAAKGMHVlpptlavDDVCQAIADARLVITSSLHGLIVGHATRTPTI 215
Cdd:pfam04230 174 AKSSKKDLEDLNEKLALLYDLP-------EELLSLISQADFVITTRLHGLILALLFGVPFI 227
WcaK COG2327
Polysaccharide pyruvyl transferase family protein WcaK (colanic acid biosynthesis) [Cell wall ...
 147-233 8.81e-04

Polysaccharide pyruvyl transferase family protein WcaK (colanic acid biosynthesis) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441900 [Multi-domain]  Cd Length: 357  Bit Score: 40.42  E-value: 8.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608354812 147 KVILLPH-FSAFGTVSGRQSIQAGAAKGMHVLPPTLAVDDVCQAIADARLVITSSLHGLIVGHATRTPTILCTFghtqep 225
Cdd:COG2327   215 KVVLLPHqYGQEDDLAIAEELAAKLKERVVVLDEELDPDELLSLIARADLVIGMRLHALIFALSAGVPVIALSY------ 288


                  ....*...
gi 1608354812 226 DFKYFDYM 233
Cdd:COG2327   289 DPKVRGLM 296
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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