|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
14-374 |
4.30e-107 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 319.82 E-value: 4.30e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 14 AADAVARRLARPvTEVEQVPLSAAKGRVLAEALRAPLDLPRFNLAAMDGYAF-------------------AGDAPGRAI 74
Cdd:cd00887 3 AARELLLALAPP-LGTETVPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVraadtagasvtlrvvgeipAGEPPDGPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 75 LEN-AIPIRTGAPLPPGLDRVVVLEDVEHHDQGMSCRRFPGEWENVRRTGSELRQGDTVLSAGSRITPAAALAAAMVGAD 153
Cdd:cd00887 82 GPGeAVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGLLASLGIA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 154 RLPVWRRIRVGFFCTGNEIAPPGSSLAPGQVWNANRPFFVSTLTRPEVALQDAGDLPDDPEAIAGALTD-LKGCDLIVTT 232
Cdd:cd00887 162 EVPVYRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALREALEEaLEEADVVITS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 233 GGSSVGEADYMAEAFLRAGGRFAVRGVALKPGKPVMMGQLGAALWLGLPGTPVAAFTCWHLFGEPLVRTVARLPLVAHRT 312
Cdd:cd00887 242 GGVSVGDYDFVKEVLEELGGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQGAPEPEPPR 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1586076846 313 E--IAAFSAVPRPGRSEIVLVRL--VKGVAQALPLLPTSTAI------ADGLAILPDTGTALHPGDAVTVLP 374
Cdd:cd00887 322 VkaRLAEDLKSKPGRREFLRVRLerDEGGLVVAPPGGQGSGLlsslarADGLIVIPEGVEGLEAGEEVEVLL 393
|
|
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
12-374 |
6.23e-105 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 314.33 E-value: 6.23e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 12 LSAADAVAR--RLARPVtEVEQVPLSAAKGRVLAEALRAPLDLPRFNLAAMDGYA--------------------FAGDA 69
Cdd:COG0303 2 ISVEEALALilAAVRPL-GTETVPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAvraadlaganpvtlrvvgeiAAGSP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 70 PGRAILEN-AIPIRTGAPLPPGLDRVVVLEDVEHHDQGMSCRRFPGEWENVRRTGSELRQGDTVLSAGSRITPAAALAAA 148
Cdd:COG0303 81 PPGPLGPGeAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAGTRLTPADLGLLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 149 MVGADRLPVWRRIRVGFFCTGNEIAPPGSSLAPGQVWNANRPFFVSTLTRPEVALQDAGDLPDDPEAIAGALTD-LKGCD 227
Cdd:COG0303 161 SLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEALRAALREaLAEAD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 228 LIVTTGGSSVGEADYMAEAFLRAGGRFAVRGVALKPGKPVMMGQLGAALWLGLPGTPVAAFTCWHLFGEPLVRTVARLPL 307
Cdd:COG0303 241 LVITSGGVSVGDYDLVKEALEELGAEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLAGLPP 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1586076846 308 VAHRTE--IAAFSAVPRPGRSEIVLVRLVK--GVAQALPLLP------TSTAIADGLAILPDTGTALHPGDAVTVLP 374
Cdd:COG0303 321 PPPPRVraRLAEDLPKKPGRTEFLRVRLERddGELVVEPLGGqgsgllSSLAEADGLIVLPEGVEGVEAGEEVEVLL 397
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
14-372 |
4.72e-73 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 238.96 E-value: 4.72e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 14 AADAVARRLARPVTEVEQVPLSAAKGRVLAEALRAPLDLPRFNLAAMDGYA-----------------------FAGDAP 70
Cdd:PRK14498 15 AREILESLLSELPLGTEEVPLEEALGRVLAEDVYAPIDVPPFDRSAMDGYAvraadtfgaseanpvrlklggevHAGEAP 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 71 GRAILEN-AIPIRTGAPLPPGLDRVVVLEDVEHHDQGM-SCRR--FPgeWENVRRTGSELRQGDTVLSAGSRITPAAALA 146
Cdd:PRK14498 95 DVEVEPGeAVEIATGAPIPRGADAVVMVEDTEEVDDDTvEIYRpvAP--GENVRPAGEDIVAGELILPKGTRLTPRDIGA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 147 AAMVGADRLPVWRRIRVGFFCTGNEIAPPGSSLAPGQVWNANRPFFVStltrpevALQDAGD-------LPDDPEAIAGA 219
Cdd:PRK14498 173 LAAGGVAEVPVYKKPRVGIISTGDELVEPGEPLKPGKIYDVNSYTLAA-------AVEEAGGepvrygiVPDDEEELEAA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 220 LTD-LKGCDLIVTTGGSSVGEADYMAEAFLRAgGRFAVRGVALKPGKPVMMGQLGAALWLGLPGTPVAAFTCWHLFGEPL 298
Cdd:PRK14498 246 LRKaLKECDLVLLSGGTSAGAGDVTYRVIEEL-GEVLVHGVAIKPGKPTILGVIGGKPVVGLPGYPVSALTIFEEFVAPL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 299 VRTVARLPLVAHRTEIAAFSA-VPRP-GRSEIVLVRLVKGVAQ--ALPLLPTSTAI-----ADGLAILPDTGTALHPGDA 369
Cdd:PRK14498 325 LRKLAGLPPPERATVKARLARrVRSElGREEFVPVSLGRVGDGyvAYPLSRGSGAItslvrADGFIEIPANTEGLEAGEE 404
|
...
gi 1586076846 370 VTV 372
Cdd:PRK14498 405 VEV 407
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
24-141 |
6.52e-30 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 112.27 E-value: 6.52e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 24 RPVTEVEQVPLSA--AKGRVLAEALRAPLDLPRFNLAAMDGYAFAGDAPGRAILEN----------------AIPIRTGA 85
Cdd:pfam03453 1 PLLGTEETVPLEAldALGRVLAEDVVAPRDVPPFDRSAMDGYAVRAADGFGASEVNpiaageppgpllpggeAVRIMTGA 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1586076846 86 PLPPGLDRVVVLEDVEHHDQGMSCRRFP-GEWENVRRTGSELRQGDTVLSAGSRITP 141
Cdd:pfam03453 81 PLPEGADAVVMVEDTEEGGGRTVEIRAPvAPGENVRRAGEDIKAGEVVLPAGTRLTP 137
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
161-297 |
3.11e-26 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 102.39 E-value: 3.11e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 161 IRVGFFCTGNEIAPPGSSLAPGQVWNANRPFFVSTLTRPEVALQDAGDLPDDPEAIAGALTD-LKGCDLIVTTGGSSVGE 239
Cdd:TIGR00177 1 PRVAVISVGDELVEGGQPLEPGQIYDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKaVDEADVVLTTGGTGVGP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1586076846 240 ADYMAEAFLRAGGRF----------AVRGVALKPGKPVMMGQLGAALWLGLPGTPVAAFTCWHLFGEP 297
Cdd:TIGR00177 81 RDVTPEALEELGEKEipgfgefrmlSSLPVLSRPGKPATAGVRGGTLIFNLPGNPVSALVTFEVLILP 148
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
164-294 |
6.45e-22 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 90.34 E-value: 6.45e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 164 GFFCTGNEIappgssLAPGQVWNANRPFFVSTLTR--PEVALQDAGDLPDDPEAIAGALTD-LKGCDLIVTTGGSSVGEA 240
Cdd:smart00852 1 AIISTGDEL------LSGGQIRDSNGPMLAALLRElgIEVVRVVVVGGPDDPEAIREALREaLAEADVVITTGGTGPGPD 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1586076846 241 DYMAEAFLRAGGR-FAVRGVALKPGKPVMM---------GQLGAALWLGLPGTPVAAFTCWHLF 294
Cdd:smart00852 75 DLTPEALAELGGReLLGHGVAMRPGGPPGPlanlsgtapGVRGKKPVFGLPGNPVAALVMFEEL 138
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
14-374 |
4.30e-107 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 319.82 E-value: 4.30e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 14 AADAVARRLARPvTEVEQVPLSAAKGRVLAEALRAPLDLPRFNLAAMDGYAF-------------------AGDAPGRAI 74
Cdd:cd00887 3 AARELLLALAPP-LGTETVPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVraadtagasvtlrvvgeipAGEPPDGPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 75 LEN-AIPIRTGAPLPPGLDRVVVLEDVEHHDQGMSCRRFPGEWENVRRTGSELRQGDTVLSAGSRITPAAALAAAMVGAD 153
Cdd:cd00887 82 GPGeAVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGLLASLGIA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 154 RLPVWRRIRVGFFCTGNEIAPPGSSLAPGQVWNANRPFFVSTLTRPEVALQDAGDLPDDPEAIAGALTD-LKGCDLIVTT 232
Cdd:cd00887 162 EVPVYRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALREALEEaLEEADVVITS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 233 GGSSVGEADYMAEAFLRAGGRFAVRGVALKPGKPVMMGQLGAALWLGLPGTPVAAFTCWHLFGEPLVRTVARLPLVAHRT 312
Cdd:cd00887 242 GGVSVGDYDFVKEVLEELGGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQGAPEPEPPR 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1586076846 313 E--IAAFSAVPRPGRSEIVLVRL--VKGVAQALPLLPTSTAI------ADGLAILPDTGTALHPGDAVTVLP 374
Cdd:cd00887 322 VkaRLAEDLKSKPGRREFLRVRLerDEGGLVVAPPGGQGSGLlsslarADGLIVIPEGVEGLEAGEEVEVLL 393
|
|
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
12-374 |
6.23e-105 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 314.33 E-value: 6.23e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 12 LSAADAVAR--RLARPVtEVEQVPLSAAKGRVLAEALRAPLDLPRFNLAAMDGYA--------------------FAGDA 69
Cdd:COG0303 2 ISVEEALALilAAVRPL-GTETVPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAvraadlaganpvtlrvvgeiAAGSP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 70 PGRAILEN-AIPIRTGAPLPPGLDRVVVLEDVEHHDQGMSCRRFPGEWENVRRTGSELRQGDTVLSAGSRITPAAALAAA 148
Cdd:COG0303 81 PPGPLGPGeAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAGTRLTPADLGLLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 149 MVGADRLPVWRRIRVGFFCTGNEIAPPGSSLAPGQVWNANRPFFVSTLTRPEVALQDAGDLPDDPEAIAGALTD-LKGCD 227
Cdd:COG0303 161 SLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEALRAALREaLAEAD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 228 LIVTTGGSSVGEADYMAEAFLRAGGRFAVRGVALKPGKPVMMGQLGAALWLGLPGTPVAAFTCWHLFGEPLVRTVARLPL 307
Cdd:COG0303 241 LVITSGGVSVGDYDLVKEALEELGAEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLAGLPP 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1586076846 308 VAHRTE--IAAFSAVPRPGRSEIVLVRLVK--GVAQALPLLP------TSTAIADGLAILPDTGTALHPGDAVTVLP 374
Cdd:COG0303 321 PPPPRVraRLAEDLPKKPGRTEFLRVRLERddGELVVEPLGGqgsgllSSLAEADGLIVLPEGVEGVEAGEEVEVLL 397
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
14-372 |
4.72e-73 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 238.96 E-value: 4.72e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 14 AADAVARRLARPVTEVEQVPLSAAKGRVLAEALRAPLDLPRFNLAAMDGYA-----------------------FAGDAP 70
Cdd:PRK14498 15 AREILESLLSELPLGTEEVPLEEALGRVLAEDVYAPIDVPPFDRSAMDGYAvraadtfgaseanpvrlklggevHAGEAP 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 71 GRAILEN-AIPIRTGAPLPPGLDRVVVLEDVEHHDQGM-SCRR--FPgeWENVRRTGSELRQGDTVLSAGSRITPAAALA 146
Cdd:PRK14498 95 DVEVEPGeAVEIATGAPIPRGADAVVMVEDTEEVDDDTvEIYRpvAP--GENVRPAGEDIVAGELILPKGTRLTPRDIGA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 147 AAMVGADRLPVWRRIRVGFFCTGNEIAPPGSSLAPGQVWNANRPFFVStltrpevALQDAGD-------LPDDPEAIAGA 219
Cdd:PRK14498 173 LAAGGVAEVPVYKKPRVGIISTGDELVEPGEPLKPGKIYDVNSYTLAA-------AVEEAGGepvrygiVPDDEEELEAA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 220 LTD-LKGCDLIVTTGGSSVGEADYMAEAFLRAgGRFAVRGVALKPGKPVMMGQLGAALWLGLPGTPVAAFTCWHLFGEPL 298
Cdd:PRK14498 246 LRKaLKECDLVLLSGGTSAGAGDVTYRVIEEL-GEVLVHGVAIKPGKPTILGVIGGKPVVGLPGYPVSALTIFEEFVAPL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 299 VRTVARLPLVAHRTEIAAFSA-VPRP-GRSEIVLVRLVKGVAQ--ALPLLPTSTAI-----ADGLAILPDTGTALHPGDA 369
Cdd:PRK14498 325 LRKLAGLPPPERATVKARLARrVRSElGREEFVPVSLGRVGDGyvAYPLSRGSGAItslvrADGFIEIPANTEGLEAGEE 404
|
...
gi 1586076846 370 VTV 372
Cdd:PRK14498 405 VEV 407
|
|
| PRK14491 |
PRK14491 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; ... |
8-374 |
7.38e-63 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional
Pssm-ID: 237729 [Multi-domain] Cd Length: 597 Bit Score: 211.40 E-value: 7.38e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 8 GAASLSAADAVARRLA--RPVTEVEQVPLSAAKGRVLAEALRAPLDLPRFNLAAMDGYAFAGDAPGRAILE--------- 76
Cdd:PRK14491 195 SPAFLSVSQGLDKILSlvTPVTETEDVALDELDGRVLAQDVISPVNVPQHTNSAMDGYAFRSDDLEPESYTlvgevlagh 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 77 ---------NAIPIRTGAPLPPGLDRVVVLEDVEHHDQGMscrRFPGEW---ENVRRTGSELRQGDTVLSAGSRITPAAA 144
Cdd:PRK14491 275 qydgtlqagEAVRIMTGAPVPAGADTVVMRELATQDGDKV---SFDGGIkagQNVRLAGEDLAQGQVALAAGTRLSAPEQ 351
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 145 LAAAMVGADRLPVWRRIRVGFFCTGNEIAPPGSSLAPGQVWNANRPFFVSTLTRPEVALQDAGDLPDDPEAIAGALTDL- 223
Cdd:PRK14491 352 GLLASLGFAEVPVFRRPKVAVFSTGDEVQAPGETLKPNCIYDSNRFTIKAMAKKLGCEVIDLGIIEDSEAALEATLEQAa 431
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 224 KGCDLIVTTGGSSVGEADYMAEAFLRAGGRFAVRgVALKPGKPVMMGQLGAALWLGLPGTPVAAFTCWHLFGEPLVRTVA 303
Cdd:PRK14491 432 AQADVVISSGGVSVGDADYIKTALAKLGQIDFWR-INMRPGRPLAFGQIGDSPFFGLPGNPVAVMVSFLQFVEPALRKLA 510
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 304 ----RLPLVAhrTEIAAFSAVPRPGRSEivlvrLVKGV---------------AQALPLLpTSTAIADGLAILPDTGTAL 364
Cdd:PRK14491 511 geqnWQPLLF--PAIADETLRSRQGRTE-----FSRGIyhlgadgrlhvrttgKQGSGIL-SSMSEANCLIEIGPAAETV 582
|
410
....*....|
gi 1586076846 365 HPGDAVTVLP 374
Cdd:PRK14491 583 NAGETVTIQP 592
|
|
| PRK14690 |
PRK14690 |
molybdopterin biosynthesis protein MoeA; Provisional |
3-374 |
2.65e-52 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 237789 [Multi-domain] Cd Length: 419 Bit Score: 179.34 E-value: 2.65e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 3 MPACIGAASLSAADAVARRLARPVTEVEQVPLSAAKGRVLAEALRAPLDLPRFNLAAMDGYAFAGDAP------------ 70
Cdd:PRK14690 16 LPPGVDWTPVDTALDLLRARLGPVTDIKELDLSDALGHVLAHDAVALRSNPPQANSAVDGYGFAGAAPegaqvlpliegr 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 71 --------GRAILENAIPIRTGAPLPPGLDRVVVLEDVEHHDQGMSCRRFPGEWENVRRTGSELRQGDTVLSAGSRITPA 142
Cdd:PRK14690 96 aaagvpfsGRVPEGMALRILTGAALPEGVDTVVLEEDVAGDGHRIAFHGPLKMGANTRKAGEDVIAGDVALPAGRRLTPA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 143 AALAAAMVGADRLPVWRRIRVGFFCTGNEIAPPGSSLAPGQVWNANRPFFVSTLTRPEVALQDAGDLPDDPEAIAGALTD 222
Cdd:PRK14690 176 DLALLSAVGLTRVSVRRPLRVAVLSTGDELVEPGALAEVGQIYDANRPMLLALARRWGHAPVDLGRVGDDRAALAARLDR 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 223 LKG-CDLIVTTGGSSVGEADYMAeAFLRAGGRFAVRGVALKPGKPVMMGQLGAALWLGLPGTPVAAFTCWHLFGEPLVRT 301
Cdd:PRK14690 256 AAAeADVILTSGGASAGDEDHVS-ALLREAGAMQSWRIALKPGRPLALGLWQGVPVFGLPGNPVAALVCTLVFARPAMSL 334
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1586076846 302 VARLPLVAHR--TEIAAFSAVPRPGRSEIVLVRLVKGVAQALPL----LPTSTAIADGLAILPDTGTALHPGDAVTVLP 374
Cdd:PRK14690 335 LAGEGWSEPQgfTVPAAFEKRKKPGRREYLRARLRQGHAEVFRSegsgRISGLSWAEGLVELGDGARRIAPGDPVRFIP 413
|
|
| PRK10680 |
PRK10680 |
molybdopterin biosynthesis protein MoeA; Provisional |
6-305 |
5.25e-52 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 182643 [Multi-domain] Cd Length: 411 Bit Score: 178.36 E-value: 5.25e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 6 CIGAASLSAADAVARRLAR--PVTEVEQVPLSAAKGRVLAEALRAPLDLPRFNLAAMDGYA------------------F 65
Cdd:PRK10680 2 EFTAGLMSLETALTEMLSRvtPLTATETLPLVQCFGRITASDIVSPLDVPGFDNSAMDGYAvrladlasgqplpvagkaF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 66 AGdAP--GRAILENAIPIRTGAPLPPGLDRVVVLEDVEHHDQGMscrRFPGE---WENVRRTGSELRQGDTVLSAGSRIT 140
Cdd:PRK10680 82 AG-QPfhGEWPAGTCIRIMTGAPVPEGCEAVVMQEQTEQTDDGV---RFTAEvrsGQNIRRRGEDISQGAVVFPAGTRLT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 141 PAAALAAAMVGADRLPVWRRIRVGFFCTGNEIAPPGSSLAPGQVWNANRPFFVSTLTRPEVALQDAGDLPDDPEAIAGAL 220
Cdd:PRK10680 158 TAELPVLASLGIAEVPVVRKVRVALFSTGDELQLPGQPLGDGQIYDTNRLAVHLMLEQLGCEVINLGIIRDDPHALRAAF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 221 TDL-KGCDLIVTTGGSSVGEADYmAEAFLRAGGRFAVRGVALKPGKPVMMGQLGAALWLGLPGTPVAA------------ 287
Cdd:PRK10680 238 IEAdSQADVVISSGGVSVGEADY-TKTILEELGEIAFWKLAIKPGKPFAFGKLSNSWFCGLPGNPVSAaltfyqlvqpll 316
|
330 340
....*....|....*....|...
gi 1586076846 288 -----FTCWHLFGEPLVRTVARL 305
Cdd:PRK10680 317 aklsgNTASGLPPRQRVRTASRL 339
|
|
| PRK14497 |
PRK14497 |
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional |
12-286 |
1.85e-39 |
|
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional
Pssm-ID: 172968 [Multi-domain] Cd Length: 546 Bit Score: 147.26 E-value: 1.85e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 12 LSAADAVARRLAR--PVTEVEQVPLSAAKGRVLAEALRAPLDLPRFNLAAMDGYAFAGD-APGR-------AILE----- 76
Cdd:PRK14497 11 YSIDEAIKVFLSSlnFKPKIVKVEVKDSFGYVSAEDLMSPIDYPPFSRSTVDGYALKSScTPGEfkvidkiGIGEfkeih 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 77 ----NAIPIRTGAPLPPGLDRVVVLEDVeHHDQGMSCR-----RFPgewENVRRTGSELRQGDTVLSAGSRITPAAALAA 147
Cdd:PRK14497 91 ikecEAVEVDTGSMIPMGADAVIKVENT-KVINGNFIKidkkiNFG---QNIGWIGSDIPKGSIILRKGEVISHEKIGLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 148 AMVGADRLPVWRRIRVGFFCTGNEIAPPGSSLAPGQVWNANRPFFVSTLTRPEVALQDAGDLPDDPEAIAGAL-TDLKGC 226
Cdd:PRK14497 167 ASLGISSVKVYEKPKIYLIATGDELVEPGNSLSPGKIYESNLHYLYSKLKSEGYKIVGLSLLSDDKESIKNEIkRAISVA 246
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 227 DLIVTTGGSSVGEADYMAEAfLRAGGRFAVRGVALKPGKPVMMGQLGAALWLGLPGTPVA 286
Cdd:PRK14497 247 DVLILTGGTSAGEKDFVHQA-IRELGNIIVHGLKIKPGKPTILGIVDGKPVIGLPGNIVS 305
|
|
| PLN02699 |
PLN02699 |
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase |
11-303 |
3.66e-33 |
|
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase
Pssm-ID: 215376 [Multi-domain] Cd Length: 659 Bit Score: 130.70 E-value: 3.66e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 11 SLSAADAVARRLArPVTeveqVPLSAAKGRVLAEALRAPLDLPRFNLAAMDGYA-FAGDAPG--------RAILE----- 76
Cdd:PLN02699 13 ALSIVLSVAARLS-PVI----VPLHEALGKVLAEDIRAPDPLPPYPASVKDGYAvVASDGPGeypvitesRAGNDglgvt 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 77 ----NAIPIRTGAPLPPGLDRVVVLEDVEHHDQGMSCRRF------PGEWENVRRTGSELRQGDTVLSAGSRITPAAALA 146
Cdd:PLN02699 88 ltpgTVAYVTTGGPIPDGADAVVQVEDTEVVEDPLDGSKRvrilsqASKGQDIRPVGCDIEKDAKVLKAGERLGASEIGL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 147 AAMVGADRLPVWRRIRVGFFCTGNEIAPPGS-SLAPGQVWNANRPFFVSTLTRPEVALQDAGDLPDDPEAIAGALTDL-- 223
Cdd:PLN02699 168 LATVGVTMVKVYPRPTVAILSTGDELVEPTTgTLGRGQIRDSNRAMLLAAAIQQQCKVVDLGIARDDEEELERILDEAis 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 224 KGCDLIVTTGGSSVGEADYMaEAFLRAGGRFAVRGVALKPGKPVMMGQLGAA---------LWLGLPGTPVAAFTCWHLF 294
Cdd:PLN02699 248 SGVDILLTSGGVSMGDRDFV-KPLLEKRGTVYFSKVLMKPGKPLTFAEIDAKsapsnskkmLAFGLPGNPVSCLVCFNLF 326
|
....*....
gi 1586076846 295 GEPLVRTVA 303
Cdd:PLN02699 327 VVPAIRYLA 335
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
24-141 |
6.52e-30 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 112.27 E-value: 6.52e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 24 RPVTEVEQVPLSA--AKGRVLAEALRAPLDLPRFNLAAMDGYAFAGDAPGRAILEN----------------AIPIRTGA 85
Cdd:pfam03453 1 PLLGTEETVPLEAldALGRVLAEDVVAPRDVPPFDRSAMDGYAVRAADGFGASEVNpiaageppgpllpggeAVRIMTGA 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1586076846 86 PLPPGLDRVVVLEDVEHHDQGMSCRRFP-GEWENVRRTGSELRQGDTVLSAGSRITP 141
Cdd:pfam03453 81 PLPEGADAVVMVEDTEEGGGRTVEIRAPvAPGENVRRAGEDIKAGEVVLPAGTRLTP 137
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
161-297 |
3.11e-26 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 102.39 E-value: 3.11e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 161 IRVGFFCTGNEIAPPGSSLAPGQVWNANRPFFVSTLTRPEVALQDAGDLPDDPEAIAGALTD-LKGCDLIVTTGGSSVGE 239
Cdd:TIGR00177 1 PRVAVISVGDELVEGGQPLEPGQIYDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKaVDEADVVLTTGGTGVGP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1586076846 240 ADYMAEAFLRAGGRF----------AVRGVALKPGKPVMMGQLGAALWLGLPGTPVAAFTCWHLFGEP 297
Cdd:TIGR00177 81 RDVTPEALEELGEKEipgfgefrmlSSLPVLSRPGKPATAGVRGGTLIFNLPGNPVSALVTFEVLILP 148
|
|
| MoCF_biosynth |
pfam00994 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
176-301 |
1.14e-23 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerization.
Pssm-ID: 425979 [Multi-domain] Cd Length: 143 Bit Score: 95.39 E-value: 1.14e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 176 GSSLAPGQVWNANRPFFVSTLTRPEVALQDAGDLPDDPEAIAGALTD-LKGCDLIVTTGGSSVGEADYMAEAFLRAGGR- 253
Cdd:pfam00994 6 GDELLPGQIRDTNGPLLAALLREAGAEVIRYGIVPDDPEAIKEALRAaAEEADVVITTGGTGPGPDDVTPEALAELGGRe 85
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1586076846 254 -----FAVRGVALKPGKPVMMGQL-----GAALWLGLPGTPVAAFTCWHLFGEPLVRT 301
Cdd:pfam00994 86 lpgfeELFRGVSLKPGKPVGTAPGailsrAGKTVFGLPGSPVAAKVMFELLLLPLLRH 143
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
164-294 |
6.45e-22 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 90.34 E-value: 6.45e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 164 GFFCTGNEIappgssLAPGQVWNANRPFFVSTLTR--PEVALQDAGDLPDDPEAIAGALTD-LKGCDLIVTTGGSSVGEA 240
Cdd:smart00852 1 AIISTGDEL------LSGGQIRDSNGPMLAALLRElgIEVVRVVVVGGPDDPEAIREALREaLAEADVVITTGGTGPGPD 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1586076846 241 DYMAEAFLRAGGR-FAVRGVALKPGKPVMM---------GQLGAALWLGLPGTPVAAFTCWHLF 294
Cdd:smart00852 75 DLTPEALAELGGReLLGHGVAMRPGGPPGPlanlsgtapGVRGKKPVFGLPGNPVAALVMFEEL 138
|
|
| MoCF_BD |
cd00758 |
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of ... |
162-299 |
1.14e-20 |
|
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin.
Pssm-ID: 238387 [Multi-domain] Cd Length: 133 Bit Score: 86.63 E-value: 1.14e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 162 RVGFFCTGNEiappgssLAPGQVWNANRPFFVSTLTRPEVALQDAGDLPDDPEAIAGALTDL-KGCDLIVTTGGSSVGEA 240
Cdd:cd00758 1 RVAIVTVSDE-------LSQGQIEDTNGPALEALLEDLGCEVIYAGVVPDDADSIRAALIEAsREADLVLTTGGTGVGRR 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 241 DYMAEAFLRAGGR-FAVRGVALKPGKPVMMGQLGAALWLGLPGTPVAAFTCWHLFGEPLV 299
Cdd:cd00758 74 DVTPEALAELGEReAHGKGVALAPGSRTAFGIIGKVLIINLPGSPKSALTTFEALVLPAL 133
|
|
| MoeA_like |
cd03522 |
MoeA_like. This domain is similar to a domain found in a variety of proteins involved in ... |
159-282 |
3.55e-09 |
|
MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is unknown.
Pssm-ID: 239599 Cd Length: 312 Bit Score: 57.56 E-value: 3.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 159 RRIRVGFFCTGNEIAPpgsslapGQVWNANRPFFVSTLTRPEVALQDAGDLPDDPEAIAGALTDLK--GCDLIVTTGGSS 236
Cdd:cd03522 158 RPLRVGLIVTGSEVYG-------GRIEDKFGPVLRARLAALGVELVEQVIVPHDEAAIAAAIAEALeaGAELLILTGGAS 230
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1586076846 237 VGEADYMAEAFLRAGGRFAVRGVALKPGKPVMMGQLGAALWLGLPG 282
Cdd:cd03522 231 VDPDDVTPAAIRAAGGEVIRYGMPVDPGNLLLLGYLGGVPVIGLPG 276
|
|
| MoaB |
COG0521 |
Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin ... |
209-322 |
1.44e-05 |
|
Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin biosynthesis enzyme MoaB/MogA is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440287 [Multi-domain] Cd Length: 169 Bit Score: 44.72 E-value: 1.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 209 LPDDPEAIAGALTDL---KGCDLIVTTGGSSVG---------------EADYMAEAF----LRAGGRFAV--RGVAlkpg 264
Cdd:COG0521 51 VPDDKDAIRAALRELiddEGVDLVLTTGGTGLSprdvtpeatrplldkELPGFGELFralsLEEIGPSAIlsRAVA---- 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1586076846 265 kpvmmGQLGAALWLGLPGTPVAAFTCWhlfgEPLvrtvarLPLVAHRTEIAAFSAVPR 322
Cdd:COG0521 127 -----GIRGGTLIFNLPGSPGAVREAL----EAI------LPELPHAVDLLNGVDHEC 169
|
|
| MogA_MoaB |
cd00886 |
MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum ... |
209-296 |
8.63e-05 |
|
MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MogA, together with MoeA, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes. In contrast, MoaB shows high similarity to MogA, but little is known about its physiological role. All well studied members of this family form highly stable trimers.
Pssm-ID: 238451 [Multi-domain] Cd Length: 152 Bit Score: 42.46 E-value: 8.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 209 LPDDPEAIAGALTDL---KGCDLIVTTGGSSVG---------------EADYMAEAFLRAGGR---FAV--RGVAlkpgk 265
Cdd:cd00886 42 VPDDKDEIREALIEWadeDGVDLILTTGGTGLAprdvtpeatrplldkELPGFGEAFRALSLEetgTAMlsRAVA----- 116
|
90 100 110
....*....|....*....|....*....|....*....
gi 1586076846 266 pvmmGQLGAALWLGLPGTPVAAFTCW--------HLFGE 296
Cdd:cd00886 117 ----GIRGGTLIFNLPGSPKAVREALevilpelpHLLDL 151
|
|
| moaC |
PRK03604 |
bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional |
209-287 |
6.55e-03 |
|
bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional
Pssm-ID: 235138 [Multi-domain] Cd Length: 312 Bit Score: 38.00 E-value: 6.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1586076846 209 LPDDPEAIAGALTDL--KGCDLIVTTGGSSVG---------------EADYMAEAFLRAGG---RFAV--RGVAlkpgkp 266
Cdd:PRK03604 197 IPDEPAEIAAAVAAWiaEGYALIITTGGTGLGprdvtpealapllerRLPGIAEALRSWGQgrtPTAMlsRLVA------ 270
|
90 100
....*....|....*....|.
gi 1586076846 267 vmmGQLGAALWLGLPGTPVAA 287
Cdd:PRK03604 271 ---GMIGNSLVVALPGSPGGA 288
|
|
| |
