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Conserved domains on  [gi|1575849863|gb|QBE96439|]
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Diacylglycerol kinase [Blautia producta]

Protein Classification

diacylglycerol/lipid kinase family protein( domain architecture ID 11446635)

diacylglycerol/lipid kinase family protein may catalyze the ATP-dependent phosphorylation of diacylglycerol and/or other lipids, and is involved in the \tphospholipid biosynthetic process

CATH:  3.40.50.10330
EC:  2.7.1.-
Gene Ontology:  GO:0008654|GO:0001727|GO:0005524|GO:0016310
SCOP:  3001940

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 1-296 1.86e-80

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


:

Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 245.53  E-value: 1.86e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863   1 MGKRMLFIFNPRAGKGSIKNRLVDILDIFVKAGYEVTVHPTQAYRDGQRVARR-KGGEYDLLVTSGGDGTLDEIVTGIMe 79
Cdd:COG1597     1 AMMRALLIVNPASGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREaAAEGADLVVAAGGDGTVNEVANGLA- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863  80 gGHSTPVGYIPAGSTNDFANSLHVSKNMLEAAVDIVEGRAHAFDVGKFNDDFFVYIAAFGLFTDVSYETNQDLKNILGHA 159
Cdd:COG1597    80 -GTGPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNGRYFLNVAGIGFDAEVVERANRALKRRLGKL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863 160 AYILEGTQRLFNIKSYNMTVESLECTMEGEFIFGMVSNATSVGGFRKLTgPDVMLDDGVFEVMLVhRPKNILELNEIIAS 239
Cdd:COG1597   159 AYVLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLA-PDASLDDGLLDVVVV-RPLSRLRLLRLLPR 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1575849863 240 MLGGA--DTKLIESFKTSSLRISCVGPVSWTLDGEFGGEHRDVEITNMKHAVQIMIAED 296
Cdd:COG1597   237 LLRGRhlRHPGVRYFRAREVEIESDRPLPVQLDGEPLGLATPLEFEVLPGALRVLVPAD 295
 
Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 1-296 1.86e-80

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 245.53  E-value: 1.86e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863   1 MGKRMLFIFNPRAGKGSIKNRLVDILDIFVKAGYEVTVHPTQAYRDGQRVARR-KGGEYDLLVTSGGDGTLDEIVTGIMe 79
Cdd:COG1597     1 AMMRALLIVNPASGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREaAAEGADLVVAAGGDGTVNEVANGLA- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863  80 gGHSTPVGYIPAGSTNDFANSLHVSKNMLEAAVDIVEGRAHAFDVGKFNDDFFVYIAAFGLFTDVSYETNQDLKNILGHA 159
Cdd:COG1597    80 -GTGPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNGRYFLNVAGIGFDAEVVERANRALKRRLGKL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863 160 AYILEGTQRLFNIKSYNMTVESLECTMEGEFIFGMVSNATSVGGFRKLTgPDVMLDDGVFEVMLVhRPKNILELNEIIAS 239
Cdd:COG1597   159 AYVLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLA-PDASLDDGLLDVVVV-RPLSRLRLLRLLPR 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1575849863 240 MLGGA--DTKLIESFKTSSLRISCVGPVSWTLDGEFGGEHRDVEITNMKHAVQIMIAED 296
Cdd:COG1597   237 LLRGRhlRHPGVRYFRAREVEIESDRPLPVQLDGEPLGLATPLEFEVLPGALRVLVPAD 295
PRK13337 PRK13337
putative lipid kinase; Reviewed
 3-297 1.36e-63

putative lipid kinase; Reviewed


Pssm-ID: 183982 [Multi-domain]  Cd Length: 304  Bit Score: 202.97  E-value: 1.36e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863   3 KRMLFIFNPRAGKGSIKNRLVDILDIFVKAGYEVTVHPTQAYRDGQRVARRKG-GEYDLLVTSGGDGTLDEIVTGIMEGG 81
Cdd:PRK13337    2 KRARIIYNPTSGRELFKKNLPDVLQKLEQAGYETSAHATTGPGDATLAAERAVeRKFDLVIAAGGDGTLNEVVNGIAEKE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863  82 HSTPVGYIPAGSTNDFANSLHVSKNMLEAAVDIVEGRAHAFDVGKFNDDFFVYIAAFGLFTDVSYETNQDLKNILGHAAY 161
Cdd:PRK13337   82 NRPKLGIIPVGTTNDFARALHVPRDIEKAADVIIEGHTVPVDIGKANNRYFINIAGGGRLTELTYEVPSKLKTMLGQLAY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863 162 ILEGTQRLFNIKSYNMTVESLECTMEGEFIFGMVSNATSVGGFRKLTgPDVMLDDGVFEVMLVHRpKNILELNEIIASML 241
Cdd:PRK13337  162 YLKGIEMLPSLKATDVRIEYDGKLFQGEIMLFLLGLTNSVGGFEKLA-PDASLDDGYFDLIIVKK-ANLAELIHIATLAL 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1575849863 242 GGA---DTKLIESfKTSSLRISCVGPVSWTLDGEFGGEhRDVEITNMKHAVQIMIAEDD 297
Cdd:PRK13337  240 RGEhikHPKVIYT-KANRIKVSSFDKMQLNLDGEYGGK-LPAEFENLYRHIEVFVPKDQ 296
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 3-293 3.97e-47

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 159.98  E-value: 3.97e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863   3 KRMLFIFNPRAGKGSIKNRLVDILDIFVKAGYEVTVHPTQAYRDGQR-VARRKGGEYDLLVTSGGDGTLDEIVTGIMEGG 81
Cdd:TIGR00147   2 AEAPAILNPTAGKSNDNKPLREVIMLLREEGMEIHVRVTWEKGDAARyVEEARKFGVDTVIAGGGDGTINEVVNALIQLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863  82 HSTPVGYIPAGSTNDFANSLHVSKNMLEAAVDIVEGRAHAFDVGKFNDDF-FVYIAAFGLFTDVSYETNQDLKNILGHAA 160
Cdd:TIGR00147  82 DIPALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVNKQYcFINMAGGGFGTEITTETPEKLKAALGSLS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863 161 YILEGTQRLFNIKSYNMTVESLECTMEGEFIFGMVSNATSVGGFRKLTgPDVMLDDGVFEVMLVhRPKNILELNEIIASM 240
Cdd:TIGR00147 162 YILSGLMRMDTLQPFRCEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLA-PDASINDGLLDLRIF-TNDNLLPALVLTLMS 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1575849863 241 LGGADTKL--IESFKTSSLRISCVGPVSWTLDGEFGGeHRDVEITNMKHAVQIMI 293
Cdd:TIGR00147 240 DEGKHTDNpnIIYGKASRIDIQTPHKITFNLDGEPLG-GTPFHIEILPAHLRCRL 293
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 4-126 4.85e-35

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 123.08  E-value: 4.85e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863   4 RMLFIFNPRAGKGSIKNRLVDILDIFVKAGYEVTVHPTQAYRDGQRVARR-KGGEYDLLVTSGGDGTLDEIVTGIMEGGH 82
Cdd:pfam00781   1 KLLVIVNPKSGGGKGKKLLRKVRPLLNKAGVEVELVLTEGPGDALELAREaAEDGYDRIVVAGGDGTVNEVLNGLAGLAT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1575849863  83 STPVGYIPAGSTNDFANSLHVSKNMLEAAVDIVEGRAHAFDVGK 126
Cdd:pfam00781  81 RPPLGIIPLGTGNDFARALGIPGDPEEALEAILKGQTRPVDVGK 124
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
 6-106 5.64e-08

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 50.37  E-value: 5.64e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863    6 LFIFNPRAGKgsikNRLVDILDIFVKAG-----YEVTVH-PTQAYRDGQRVARrkggeYDLLVTSGGDGTLDEIVTGIME 79
Cdd:smart00046   1 LVFVNPKSGG----GKGEKLLRKFRLLLnprqvFDLTKKgPAVALVIFRDVPD-----FNRVLVCGGDGTVGWVLNALDK 71

                           90       100       110
                   ....*....|....*....|....*....|
gi 1575849863   80 G---GHSTPVGYIPAGSTNDFANSLHVSKN 106
Cdd:smart00046  72 RelpLPEPPVAVLPLGTGNDLARSLGWGGG 101
 
Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 1-296 1.86e-80

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 245.53  E-value: 1.86e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863   1 MGKRMLFIFNPRAGKGSIKNRLVDILDIFVKAGYEVTVHPTQAYRDGQRVARR-KGGEYDLLVTSGGDGTLDEIVTGIMe 79
Cdd:COG1597     1 AMMRALLIVNPASGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREaAAEGADLVVAAGGDGTVNEVANGLA- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863  80 gGHSTPVGYIPAGSTNDFANSLHVSKNMLEAAVDIVEGRAHAFDVGKFNDDFFVYIAAFGLFTDVSYETNQDLKNILGHA 159
Cdd:COG1597    80 -GTGPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNGRYFLNVAGIGFDAEVVERANRALKRRLGKL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863 160 AYILEGTQRLFNIKSYNMTVESLECTMEGEFIFGMVSNATSVGGFRKLTgPDVMLDDGVFEVMLVhRPKNILELNEIIAS 239
Cdd:COG1597   159 AYVLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLA-PDASLDDGLLDVVVV-RPLSRLRLLRLLPR 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1575849863 240 MLGGA--DTKLIESFKTSSLRISCVGPVSWTLDGEFGGEHRDVEITNMKHAVQIMIAED 296
Cdd:COG1597   237 LLRGRhlRHPGVRYFRAREVEIESDRPLPVQLDGEPLGLATPLEFEVLPGALRVLVPAD 295
PRK13337 PRK13337
putative lipid kinase; Reviewed
 3-297 1.36e-63

putative lipid kinase; Reviewed


Pssm-ID: 183982 [Multi-domain]  Cd Length: 304  Bit Score: 202.97  E-value: 1.36e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863   3 KRMLFIFNPRAGKGSIKNRLVDILDIFVKAGYEVTVHPTQAYRDGQRVARRKG-GEYDLLVTSGGDGTLDEIVTGIMEGG 81
Cdd:PRK13337    2 KRARIIYNPTSGRELFKKNLPDVLQKLEQAGYETSAHATTGPGDATLAAERAVeRKFDLVIAAGGDGTLNEVVNGIAEKE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863  82 HSTPVGYIPAGSTNDFANSLHVSKNMLEAAVDIVEGRAHAFDVGKFNDDFFVYIAAFGLFTDVSYETNQDLKNILGHAAY 161
Cdd:PRK13337   82 NRPKLGIIPVGTTNDFARALHVPRDIEKAADVIIEGHTVPVDIGKANNRYFINIAGGGRLTELTYEVPSKLKTMLGQLAY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863 162 ILEGTQRLFNIKSYNMTVESLECTMEGEFIFGMVSNATSVGGFRKLTgPDVMLDDGVFEVMLVHRpKNILELNEIIASML 241
Cdd:PRK13337  162 YLKGIEMLPSLKATDVRIEYDGKLFQGEIMLFLLGLTNSVGGFEKLA-PDASLDDGYFDLIIVKK-ANLAELIHIATLAL 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1575849863 242 GGA---DTKLIESfKTSSLRISCVGPVSWTLDGEFGGEhRDVEITNMKHAVQIMIAEDD 297
Cdd:PRK13337  240 RGEhikHPKVIYT-KANRIKVSSFDKMQLNLDGEYGGK-LPAEFENLYRHIEVFVPKDQ 296
PRK13055 PRK13055
putative lipid kinase; Reviewed
 1-300 4.56e-61

putative lipid kinase; Reviewed


Pssm-ID: 237282 [Multi-domain]  Cd Length: 334  Bit Score: 197.14  E-value: 4.56e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863   1 MGKRMLFIFNPRAGKGSIKNRLVDILDIFVKAGYEVTVHPTQAYRD-GQRVARR--KGGeYDLLVTSGGDGTLDEIVTGI 77
Cdd:PRK13055    1 MQKRARLIYNPTSGQEIMKKNVADILDILEQAGYETSAFQTTPEPNsAKNEAKRaaEAG-FDLIIAAGGDGTINEVVNGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863  78 MEGGHSTPVGYIPAGSTNDFANSLHVSK-NMLEAAVDIVEGRAHAFDVGKFNDD-FFVYIAAFGLFTDVSYETNQDLKNI 155
Cdd:PRK13055   80 APLEKRPKMAIIPAGTTNDYARALKIPRdNPVEAAKVILKNQTIKMDIGRANEDkYFINIAAGGSLTELTYSVPSQLKSM 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863 156 LGHAAYILEGTQRLFNIKSYNMTVESLECTMEGE--FIFGMVSNatSVGGFRKLTgPDVMLDDGVFEVMLVhRPKNILEL 233
Cdd:PRK13055  160 FGYLAYLAKGAELLPRVSPVPVRITYDEGVFEGKisMFFLALTN--SVGGFEQIV-PDAKLDDGKFTLIIV-KTANLFEL 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1575849863 234 NEIIASMLGGA---DTKLIESFKTSSLRISCVG--PVSWTLDGEFGGeHRDVEITNMKHAVQiMIAEDDTVP 300
Cdd:PRK13055  236 LHLMALILNGGkhiDDPRVIYIKTSKLTIEPLGddRLMVNLDGEYGG-DAPMTFENLKQHIE-FFANTDEIS 305
PRK13059 PRK13059
putative lipid kinase; Reviewed
 3-292 1.01e-53

putative lipid kinase; Reviewed


Pssm-ID: 183858  Cd Length: 295  Bit Score: 177.15  E-value: 1.01e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863   3 KRMLFIFNPRAGKGSIKNRLVDILDIFVKAGYEVTVHPTQAYRDGQRVARRKGGEYDLLVTSGGDGTLDEIVTGIMEGGH 82
Cdd:PRK13059    2 KKVKFIYNPYSGENAIISELDKVIRIHQEKGYLVVPYRISLEYDLKNAFKDIDESYKYILIAGGDGTVDNVVNAMKKLNI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863  83 STPVGYIPAGSTNDFANSLHVSKNMLEAAVDIVEGRAHAFDVGKFNDDFFVYIAAFGLFTDVSYETNQDLKNILGHAAYI 162
Cdd:PRK13059   82 DLPIGILPVGTANDFAKFLGMPTDIGEACEQILKSKPKKVDLGKINDKYFINVASTGLFTDVSQKTDVNLKNTIGKLAYY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863 163 LEGTQRLFNIKSYNMTVESLECTMEGEFIFGMVSNATSVGGFRKLTGPDVmlDDGVFEVMLVhRPKNILELNEIIASMLG 242
Cdd:PRK13059  162 LKGLEELPNFRKLKVKVTSEEVNFDGDMYLMLVFNGQTAGNFNLAYKAEV--DDGLLDVIII-KACPIIDLIPLFIKVLK 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1575849863 243 GA---DTKLIESFKTSSLRISCVGPVSWTLDGEfGGEHRDVEITNMKHAVQIM 292
Cdd:PRK13059  239 GEhleDVNGLIYFKTDKLEIESNEEIVTDIDGE-RGPDFPLNIECIKGGLKVL 290
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 3-293 3.97e-47

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 159.98  E-value: 3.97e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863   3 KRMLFIFNPRAGKGSIKNRLVDILDIFVKAGYEVTVHPTQAYRDGQR-VARRKGGEYDLLVTSGGDGTLDEIVTGIMEGG 81
Cdd:TIGR00147   2 AEAPAILNPTAGKSNDNKPLREVIMLLREEGMEIHVRVTWEKGDAARyVEEARKFGVDTVIAGGGDGTINEVVNALIQLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863  82 HSTPVGYIPAGSTNDFANSLHVSKNMLEAAVDIVEGRAHAFDVGKFNDDF-FVYIAAFGLFTDVSYETNQDLKNILGHAA 160
Cdd:TIGR00147  82 DIPALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVNKQYcFINMAGGGFGTEITTETPEKLKAALGSLS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863 161 YILEGTQRLFNIKSYNMTVESLECTMEGEFIFGMVSNATSVGGFRKLTgPDVMLDDGVFEVMLVhRPKNILELNEIIASM 240
Cdd:TIGR00147 162 YILSGLMRMDTLQPFRCEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLA-PDASINDGLLDLRIF-TNDNLLPALVLTLMS 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1575849863 241 LGGADTKL--IESFKTSSLRISCVGPVSWTLDGEFGGeHRDVEITNMKHAVQIMI 293
Cdd:TIGR00147 240 DEGKHTDNpnIIYGKASRIDIQTPHKITFNLDGEPLG-GTPFHIEILPAHLRCRL 293
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 4-126 4.85e-35

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 123.08  E-value: 4.85e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863   4 RMLFIFNPRAGKGSIKNRLVDILDIFVKAGYEVTVHPTQAYRDGQRVARR-KGGEYDLLVTSGGDGTLDEIVTGIMEGGH 82
Cdd:pfam00781   1 KLLVIVNPKSGGGKGKKLLRKVRPLLNKAGVEVELVLTEGPGDALELAREaAEDGYDRIVVAGGDGTVNEVLNGLAGLAT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1575849863  83 STPVGYIPAGSTNDFANSLHVSKNMLEAAVDIVEGRAHAFDVGK 126
Cdd:pfam00781  81 RPPLGIIPLGTGNDFARALGIPGDPEEALEAILKGQTRPVDVGK 124
PRK13054 PRK13054
lipid kinase; Reviewed
 31-272 1.19e-34

lipid kinase; Reviewed


Pssm-ID: 237281 [Multi-domain]  Cd Length: 300  Bit Score: 127.30  E-value: 1.19e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863  31 KAGYEVTVHPTQAYRDGQRVAR--RKGGeYDLLVTSGGDGTLDEIVTGIM--EGGHSTPVGYIPAGSTNDFANSLHVSKN 106
Cdd:PRK13054   29 EEGHTLHVRVTWEKGDAARYVEeaLALG-VATVIAGGGDGTINEVATALAqlEGDARPALGILPLGTANDFATAAGIPLE 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863 107 MLEAAVDIVEGRAHAFDVGKFNDD-FFVYIAAFGLFTDVSYETNQDLKNILGHAAYILEGTQRLFNIKSYNMTVESLECT 185
Cdd:PRK13054  108 PDKALKLAIEGRAQPIDLARVNDRtYFINMATGGFGTRVTTETPEKLKAALGGVAYLIHGLMRMDTLKPDRCEIRGPDFH 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863 186 MEGEFIFGMVSNATSVGGFRKLTgPDVMLDDGVFEVMLVHRPKNIL-ELNEIIASmlGGADTKLIESFKTSSLRISCVGP 264
Cdd:PRK13054  188 WQGDALVIGIGNGRQAGGGQQLC-PEALINDGLLDLRILPAPQELLpTLLSTLTG--GSEDNPNIIRARLPWLEIQAPHE 264


                  ....*...
gi 1575849863 265 VSWTLDGE 272
Cdd:PRK13054  265 LTFNLDGE 272
PRK00861 PRK00861
putative lipid kinase; Reviewed
 1-298 4.41e-27

putative lipid kinase; Reviewed


Pssm-ID: 234850 [Multi-domain]  Cd Length: 300  Bit Score: 107.40  E-value: 4.41e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863   1 MGKRMLFIFNPRAGKG-------SIKNRLVDILDIFVkagYEVT--VHPTQAYRDgqrvARRKGgeYDLLVTSGGDGTLD 71
Cdd:PRK00861    1 MTRSACLIFNPVAGQGnpevdlaLIRAILEPEMDLDI---YLTTpeIGADQLAQE----AIERG--AELIIASGGDGTLS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863  72 EIVTGIMEGGhsTPVGYIPAGSTNDFANSLHVSKNMLEAAVDIVEGRAHAFDVGKFNDDFFVYIAAFGLFTDVSYETNQD 151
Cdd:PRK00861   72 AVAGALIGTD--IPLGIIPRGTANAFAAALGIPDTIEEACRTILQGKTRRVDVAYCNGQPMILLAGIGFEAETVEEADRE 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863 152 LKNILGHAAYILEGTQRLFNIKSYNMTVESLECTMEGEFIFGMVSNA---TSV--GGFrkltgPDVMLDDGVFEVMLVhR 226
Cdd:PRK00861  150 AKNRFGILAYILSGLQQLRELESFEVEIETEDQIITTNAVAVTVANAappTSVlaQGP-----GAVIPDDGLLDVTIV-A 223

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1575849863 227 PKNILEL----NEIIASMLGG--ADTKLIESFKTSSLRISCVGPVSWTLDGEFGGEhRDVEITNMKHAVQIMIAEDDT 298
Cdd:PRK00861  224 PKNLAEAvaasYHLLQTALQGnpAERDDIGYLRAKQVKITTDPPQKVVIDGEVVGT-TPIEIECLPRSLKVFAPLQAE 300
PRK13057 PRK13057
lipid kinase;
6-161 4.12e-18

lipid kinase;


Pssm-ID: 183857 [Multi-domain]  Cd Length: 287  Bit Score: 82.27  E-value: 4.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863   6 LFIFNPRAGKGsiKNRLVDILDIFVKAGYEVTVHPTQAYRDGQRVARRKGGEYDLLVTSGGDGTLDEIVTGIMEGGhsTP 85
Cdd:PRK13057    1 LLLVNRHARSG--RAALAAARAALEAAGLELVEPPAEDPDDLSEVIEAYADGVDLVIVGGGDGTLNAAAPALVETG--LP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1575849863  86 VGYIPAGSTNDFANSLHVSKNMLEAAVDIVEGRAHAFDVGKFNDDFFVYIAAFGLFTDVSYETNQDLKNILGHAAY 161
Cdd:PRK13057   77 LGILPLGTANDLARTLGIPLDLEAAARVIATGQVRRIDLGWVNGHYFFNVASLGLSAELARRLTKELKRRWGTLGY 152
PLN02958 PLN02958
diacylglycerol kinase/D-erythro-sphingosine kinase
 3-176 1.51e-11

diacylglycerol kinase/D-erythro-sphingosine kinase


Pssm-ID: 215517 [Multi-domain]  Cd Length: 481  Bit Score: 64.50  E-value: 1.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863   3 KRMLFIFNPRAGKGSIKNRLVDILD-IFVKAGYEVTVHPTQAYRDGQRVARRKG-GEYDLLVTSGGDGTLDEIVTGIME- 79
Cdd:PLN02958  112 KRLLVFVNPFGGKKSASKIFFDVVKpLLEDADIQLTIQETKYQLHAKEVVRTMDlSKYDGIVCVSGDGILVEVVNGLLEr 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863  80 ----GGHSTPVGYIPAGSTNDFANSLHVSKNM----LEAAVDIVEGRAHAFDVG-------KFnddFFVYIAAFGLFTDV 144
Cdd:PLN02958  192 edwkTAIKLPIGMVPAGTGNGMAKSLLDSVGEpcsaTNAVLAIIRGHKCSLDVAtilqgetKF---FSVLMLAWGLVADI 268

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1575849863 145 SYETNQdlKNILGHAAYILEGTQRLFNIKSYN 176
Cdd:PLN02958  269 DIESEK--YRWMGSARLDFYGLQRILCLRQYN 298
PRK12361 PRK12361
hypothetical protein; Provisional
 3-282 1.63e-10

hypothetical protein; Provisional


Pssm-ID: 183473 [Multi-domain]  Cd Length: 547  Bit Score: 61.56  E-value: 1.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863   3 KRMLFIFNPRAGKGSIKNRLVDILDiFVKAGYEVTVHPTQAYRDGQRVAR--RKGGEyDLLVTSGGDGTLDEIVTGIMeg 80
Cdd:PRK12361  243 KRAWLIANPVSGGGKWQEYGEQIQR-ELKAYFDLTVKLTTPEISAEALAKqaRKAGA-DIVIACGGDGTVTEVASELV-- 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863  81 GHSTPVGYIPAGSTNDFANSLHVSKNML---EAAVD-IVEGRAHAFDVGKFNDDFFVYIAAFGLFTDVSYETNQDLKNIL 156
Cdd:PRK12361  319 NTDITLGIIPLGTANALSHALFGLGSKLipvEQACDnIIQGHTQRIDTARCNDRLMLLLVGIGFEQKMIESADRERKNAL 398

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863 157 GHAAYiLEGTQRLFNiksyNMTVESLECTMEGEFIFGM------VSNA---TSV----GGfrkltGPDVmlDDGVFEVML 223
Cdd:PRK12361  399 GQLAY-LDGLWRAVN----ENETLTLTVTLDDAEPQTIsthslvVANAapfTSLlaqgGG-----EPNM--TDGLLDITW 466

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1575849863 224 VHR----PKNILELNE-IIASMLGGADTKLIESFKTSSLRISCVGPVSWTLDGE-FGGEHRDVEI 282
Cdd:PRK12361  467 LDSggepGEQLLSLAElALSGLGKEPEANKVHHAHAKKVTISSQKPIKYVIDGElFEDEDLTIEV 531
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
 6-106 5.64e-08

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 50.37  E-value: 5.64e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863    6 LFIFNPRAGKgsikNRLVDILDIFVKAG-----YEVTVH-PTQAYRDGQRVARrkggeYDLLVTSGGDGTLDEIVTGIME 79
Cdd:smart00046   1 LVFVNPKSGG----GKGEKLLRKFRLLLnprqvFDLTKKgPAVALVIFRDVPD-----FNRVLVCGGDGTVGWVLNALDK 71

                           90       100       110
                   ....*....|....*....|....*....|
gi 1575849863   80 G---GHSTPVGYIPAGSTNDFANSLHVSKN 106
Cdd:smart00046  72 RelpLPEPPVAVLPLGTGNDLARSLGWGGG 101
PRK11914 PRK11914
diacylglycerol kinase; Reviewed
 59-292 4.10e-06

diacylglycerol kinase; Reviewed


Pssm-ID: 237021 [Multi-domain]  Cd Length: 306  Bit Score: 47.47  E-value: 4.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863  59 DLLVTSGGDGTldeIVTGIMEGGHS-TPVGYIPAGSTNDFANSLHVSKNMLEAAVD-IVEGRAHAFDVGKFNDD-----F 131
Cdd:PRK11914   66 DALVVVGGDGV---ISNALQVLAGTdIPLGIIPAGTGNDHAREFGIPTGDPEAAADvIVDGWTETVDLGRIQDDdgivkW 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863 132 FVYIAAFGLFTDVSYETNQdLKNILGHAAYILEGTQRLFNIK--SYNMTVESLEcTMEGEFIFGMVSNATSVGGFRKLTg 209
Cdd:PRK11914  143 FGTVAATGFDSLVTDRANR-MRWPHGRMRYNLAMLAELSKLRplPFRLVLDGTE-EIVTDLTLAAFGNTRSYGGGMLIC- 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863 210 PDVMLDDGVFEVMLVHRPKNiLELNEIIASMLGGADTKL--IESFKTSSLRISCVGPVSWTlDGEFGGEhRDVEITNMKH 287
Cdd:PRK11914  220 PNADHTDGLLDITMVQSASR-TRLLRLFPTVFKGTHVELdeVSTARAKTVHVECPGINAYA-DGDFACP-LPAEISAVPG 296


                  ....*
gi 1575849863 288 AVQIM 292
Cdd:PRK11914  297 ALQIL 301
PLN02204 PLN02204
diacylglycerol kinase
 3-108 1.96e-03

diacylglycerol kinase


Pssm-ID: 215126 [Multi-domain]  Cd Length: 601  Bit Score: 39.87  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575849863   3 KRMLFIFNPRAGKGSIKNRLVDILDIFVKAGYEVTVHPTQ----AYRDGQRVARRKGGEYDLLVTSGGDGTLDEIVTGIM 78
Cdd:PLN02204  160 KNLLVFVHPLSGKGSGSRTWETVSPIFIRAKVKTKVIVTEraghAFDVMASISNKELKSYDGVIAVGGDGFFNEILNGYL 239

                          90       100       110
                  ....*....|....*....|....*....|
gi 1575849863  79 EGGHSTPvgYIPAGStnDFANSLHVSKNML 108
Cdd:PLN02204  240 LSRLKVP--YPPSPS--DSVHSVQSRGSSS 265
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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