|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
94-301 |
1.66e-17 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 83.83 E-value: 1.66e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 94 RNLFLTGNQMTVLPAgAFARqppLADLEALNLSGNHLKEVCAgAFEHLPGLRRLDLSHNPLTNLSAFAFAGSNasvsaps 173
Cdd:COG4886 116 ESLDLSGNQLTDLPE-ELAN---LTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLTN------- 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 174 pLEELIL--NHIvppedqrqngsfegmvafegmvaAALRSGLA-LRGLTRLELASNHFLFLPRDLlAQLPSLRYLDLRNN 250
Cdd:COG4886 184 -LKELDLsnNQI-----------------------TDLPEPLGnLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNN 238
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 342187131 251 SLVSLtyASFRNLTHLESLHLEDNALKVLhnSTLAEWHGLAHVKvfLDNNP 301
Cdd:COG4886 239 QLTDL--PELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLD--LSNNQ 283
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
300-351 |
1.03e-11 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 59.37 E-value: 1.03e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 342187131 300 NPWVCDCYMADMVAWLKETEVVPDKARLTCAFPEKMRNRgLLDLNSSDLDCD 351
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
216-276 |
1.98e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 59.08 E-value: 1.98e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 342187131 216 RGLTRLELASNHFLFLPRDLLAQLPSLRYLDLRNNSLVSLTYASFRNLTHLESLHLEDNAL 276
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
75-304 |
4.03e-10 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 59.41 E-value: 4.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 75 VKCVNRNLLEVPA-DLPPYVRNLFLTGNQMTVLPAGAFARQppladLEALNLSGNHLKEVCAgaFEHLPGLRRLDLSHNP 153
Cdd:cd21340 7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIENLEFLTN-----LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 154 LTNLSAFafagsnasvSAPSPLEELilnHIvppEDQRqngsfegmvafegmvaaaLRSGLALrgltrlelasnhfLFLPR 233
Cdd:cd21340 80 ISVVEGL---------ENLTNLEEL---HI---ENQR------------------LPPGEKL-------------TFDPR 113
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 342187131 234 DLLAQLPSLRYLDLRNNSLVSLTyaSFRNLTHLESLHLEDNALKVLHN--STLAEWHGLAHVKvfLDNNPwVC 304
Cdd:cd21340 114 SLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELD--LTGNP-VC 181
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
79-279 |
3.10e-06 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 49.70 E-value: 3.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 79 NRNLLEVPADLPPYVRNLFLTGNQMTVLPAgafarqpPLAD-LEALNLSGNHLKEVCagafEHLP-GLRRLDLSHNPLTN 156
Cdd:PRK15370 208 NNELKSLPENLQGNIKTLYANSNQLTSIPA-------TLPDtIQEMELSINRITELP----ERLPsALQSLDLFHNKISC 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 157 LsafafagsnasvsaPSPLeelilnhivpPEDQRQNGSFEGMVAfegMVAAALRSglalrGLTRLELASNHFLFLPRDLl 236
Cdd:PRK15370 277 L--------------PENL----------PEELRYLSVYDNSIR---TLPAHLPS-----GITHLNVQSNSLTALPETL- 323
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 342187131 237 aqLPSLRYLDLRNNSLVSLTyASFRnlTHLESLHLEDNALKVL 279
Cdd:PRK15370 324 --PPGLKTLEAGENALTSLP-ASLP--PELQVLDVSKNQITVL 361
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
271-357 |
1.39e-05 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 47.77 E-value: 1.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 271 LEDNALKVLHNSTLAEWHGLAHVKvfLDNNPWVCDCYMADMVAWLKETEV-VPDKARLTCAFPEKMRNRGLLDLNSSDLD 349
Cdd:TIGR00864 2 ISNNKISTIEEGICANLCNLSEID--LSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGQPLLGIPLLDSG 79
|
90
....*....|..
gi 342187131 350 CD----AVLPQS 357
Cdd:TIGR00864 80 CDeeyvACLKDN 91
|
|
| LRRNT |
smart00013 |
Leucine rich repeat N-terminal domain; |
62-95 |
4.14e-05 |
|
Leucine rich repeat N-terminal domain;
Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 40.38 E-value: 4.14e-05
10 20 30
....*....|....*....|....*....|....
gi 342187131 62 CPAACECSeaARTVKCVNRNLLEVPADLPPYVRN 95
Cdd:smart00013 2 CPAPCNCS--GTAVDCSGRGLTEVPLDLPPDTTL 33
|
|
| LRRNT |
pfam01462 |
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ... |
62-90 |
5.01e-04 |
|
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.
Pssm-ID: 396168 [Multi-domain] Cd Length: 28 Bit Score: 37.22 E-value: 5.01e-04
10 20
....*....|....*....|....*....
gi 342187131 62 CPAACECSeaARTVKCVNRNLLEVPADLP 90
Cdd:pfam01462 2 CPVPCHCS--ATVVNCSDRGLTAVPRDLP 28
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
94-301 |
1.66e-17 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 83.83 E-value: 1.66e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 94 RNLFLTGNQMTVLPAgAFARqppLADLEALNLSGNHLKEVCAgAFEHLPGLRRLDLSHNPLTNLSAFAFAGSNasvsaps 173
Cdd:COG4886 116 ESLDLSGNQLTDLPE-ELAN---LTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLTN------- 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 174 pLEELIL--NHIvppedqrqngsfegmvafegmvaAALRSGLA-LRGLTRLELASNHFLFLPRDLlAQLPSLRYLDLRNN 250
Cdd:COG4886 184 -LKELDLsnNQI-----------------------TDLPEPLGnLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNN 238
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 342187131 251 SLVSLtyASFRNLTHLESLHLEDNALKVLhnSTLAEWHGLAHVKvfLDNNP 301
Cdd:COG4886 239 QLTDL--PELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLD--LSNNQ 283
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
79-290 |
3.21e-17 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 83.06 E-value: 3.21e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 79 NRNLLEVPADLP--PYVRNLFLTGNQMTVLPAgAFARqppLADLEALNLSGNHLKEVCAgAFEHLPGLRRLDLSHNPLTN 156
Cdd:COG4886 122 GNQLTDLPEELAnlTNLKELDLSNNQLTDLPE-PLGN---LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITD 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 157 LSafafagsnASVSAPSPLEELIL--NHIvppedqrqngsfegmvafegmvaAALRSGLA-LRGLTRLELASNHFLFLPR 233
Cdd:COG4886 197 LP--------EPLGNLTNLEELDLsgNQL-----------------------TDLPEPLAnLTNLETLDLSNNQLTDLPE 245
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 342187131 234 dlLAQLPSLRYLDLRNNSLVSLTyaSFRNLTHLESLHLEDNALKVLHNSTLAEWHGL 290
Cdd:COG4886 246 --LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGL 298
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
117-300 |
2.58e-12 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 68.04 E-value: 2.58e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 117 LADLEALNLSGNHLKEVCAgAFEHLPGLRRLDLSHNPLTNLsafafagsnasvsaPSPLEELilnhivppedqrqngsfe 196
Cdd:COG4886 112 LTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL--------------PEPLGNL------------------ 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 197 gmvafegmvaaalrsglalRGLTRLELASNHFLFLPRDLlAQLPSLRYLDLRNNSLVSLTyASFRNLTHLESLHLEDNAL 276
Cdd:COG4886 159 -------------------TNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQL 217
|
170 180
....*....|....*....|....
gi 342187131 277 KVLhNSTLAEWHGLAHvkVFLDNN 300
Cdd:COG4886 218 TDL-PEPLANLTNLET--LDLSNN 238
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
300-351 |
1.03e-11 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 59.37 E-value: 1.03e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 342187131 300 NPWVCDCYMADMVAWLKETEVVPDKARLTCAFPEKMRNRgLLDLNSSDLDCD 351
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
216-276 |
1.98e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 59.08 E-value: 1.98e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 342187131 216 RGLTRLELASNHFLFLPRDLLAQLPSLRYLDLRNNSLVSLTYASFRNLTHLESLHLEDNAL 276
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
91-154 |
3.50e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 58.30 E-value: 3.50e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 342187131 91 PYVRNLFLTGNQMTVLPAGAFARqppLADLEALNLSGNHLKEVCAGAFEHLPGLRRLDLSHNPL 154
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKG---LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
75-304 |
4.03e-10 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 59.41 E-value: 4.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 75 VKCVNRNLLEVPA-DLPPYVRNLFLTGNQMTVLPAGAFARQppladLEALNLSGNHLKEVCAgaFEHLPGLRRLDLSHNP 153
Cdd:cd21340 7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIENLEFLTN-----LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 154 LTNLSAFafagsnasvSAPSPLEELilnHIvppEDQRqngsfegmvafegmvaaaLRSGLALrgltrlelasnhfLFLPR 233
Cdd:cd21340 80 ISVVEGL---------ENLTNLEEL---HI---ENQR------------------LPPGEKL-------------TFDPR 113
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 342187131 234 DLLAQLPSLRYLDLRNNSLVSLTyaSFRNLTHLESLHLEDNALKVLHN--STLAEWHGLAHVKvfLDNNPwVC 304
Cdd:cd21340 114 SLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELD--LTGNP-VC 181
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
79-300 |
7.43e-10 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 60.33 E-value: 7.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 79 NRNLLEVPADLPPYVRNLFLTGNQMTVLPAGAFARQPPLADLEALNLSGNhlkevcaGAFEHLPGLRRLDLSHNPLTNLs 158
Cdd:COG4886 57 LRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 159 afafagsnasvsaPSPLEELilnhivppedqrqngsfegmvafegmvaaalrsglalRGLTRLELASNHFLFLPRDLlAQ 238
Cdd:COG4886 129 -------------PEELANL-------------------------------------TNLKELDLSNNQLTDLPEPL-GN 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 342187131 239 LPSLRYLDLRNNSLVSLTyASFRNLTHLESLHLEDNALKVLHNStLAEWHGLahVKVFLDNN 300
Cdd:COG4886 158 LTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPEP-LGNLTNL--EELDLSGN 215
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
120-182 |
6.83e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 51.76 E-value: 6.83e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 342187131 120 LEALNLSGNHLKEVCAGAFEHLPGLRRLDLSHNPLTNLSAFAFAGSNAsvsapspLEELILNH 182
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPS-------LRYLDLSG 58
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
94-279 |
8.77e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 57.25 E-value: 8.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 94 RNLFLTGNQMTVLPAgAFARqppLADLEALNLSGNHLKEVcAGAFEHLPGLRRLDLSHNPLTNLSAFAfagsnasvsaps 173
Cdd:COG4886 185 KELDLSNNQITDLPE-PLGN---LTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPELG------------ 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 174 pleelilnhivppedqrqngsfegmvafegmvaaalrsglALRGLTRLELASNHFLFLPrdLLAQLPSLRYLDLRNNSLV 253
Cdd:COG4886 248 ----------------------------------------NLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLT 285
|
170 180
....*....|....*....|....*.
gi 342187131 254 SLTYASFRNLTHLESLHLEDNALKVL 279
Cdd:COG4886 286 DLKLKELELLLGLNSLLLLLLLLNLL 311
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
240-301 |
3.50e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 47.13 E-value: 3.50e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 342187131 240 PSLRYLDLRNNSLVSLTYASFRNLTHLESLHLEDNALKVLHNSTLaewHGLAHVKV-FLDNNP 301
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAF---SGLPSLRYlDLSGNR 60
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
79-279 |
3.10e-06 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 49.70 E-value: 3.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 79 NRNLLEVPADLPPYVRNLFLTGNQMTVLPAgafarqpPLAD-LEALNLSGNHLKEVCagafEHLP-GLRRLDLSHNPLTN 156
Cdd:PRK15370 208 NNELKSLPENLQGNIKTLYANSNQLTSIPA-------TLPDtIQEMELSINRITELP----ERLPsALQSLDLFHNKISC 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 157 LsafafagsnasvsaPSPLeelilnhivpPEDQRQNGSFEGMVAfegMVAAALRSglalrGLTRLELASNHFLFLPRDLl 236
Cdd:PRK15370 277 L--------------PENL----------PEELRYLSVYDNSIR---TLPAHLPS-----GITHLNVQSNSLTALPETL- 323
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 342187131 237 aqLPSLRYLDLRNNSLVSLTyASFRnlTHLESLHLEDNALKVL 279
Cdd:PRK15370 324 --PPGLKTLEAGENALTSLP-ASLP--PELQVLDVSKNQITVL 361
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
119-276 |
3.88e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 48.51 E-value: 3.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 119 DLEALNLSGNHLKE------VCAGAFEHLPGLRRLDLSHNPLTNLSAFAFagsnASVSAPSPLEELILNhivppedqrqN 192
Cdd:cd00116 52 SLKELCLSLNETGRiprglqSLLQGLTKGCGLQELDLSDNALGPDGCGVL----ESLLRSSSLQELKLN----------N 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 193 GSFEGMVafEGMVAAALRS-GLALRGL----TRLELASNHFLflpRDLLAQLPSLRYLDLRNNSL----VSLTYASFRNL 263
Cdd:cd00116 118 NGLGDRG--LRLLAKGLKDlPPALEKLvlgrNRLEGASCEAL---AKALRANRDLKELNLANNGIgdagIRALAEGLKAN 192
|
170
....*....|...
gi 342187131 264 THLESLHLEDNAL 276
Cdd:cd00116 193 CNLEVLDLNNNGL 205
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
271-357 |
1.39e-05 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 47.77 E-value: 1.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 271 LEDNALKVLHNSTLAEWHGLAHVKvfLDNNPWVCDCYMADMVAWLKETEV-VPDKARLTCAFPEKMRNRGLLDLNSSDLD 349
Cdd:TIGR00864 2 ISNNKISTIEEGICANLCNLSEID--LSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGQPLLGIPLLDSG 79
|
90
....*....|..
gi 342187131 350 CD----AVLPQS 357
Cdd:TIGR00864 80 CDeeyvACLKDN 91
|
|
| LRRNT |
smart00013 |
Leucine rich repeat N-terminal domain; |
62-95 |
4.14e-05 |
|
Leucine rich repeat N-terminal domain;
Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 40.38 E-value: 4.14e-05
10 20 30
....*....|....*....|....*....|....
gi 342187131 62 CPAACECSeaARTVKCVNRNLLEVPADLPPYVRN 95
Cdd:smart00013 2 CPAPCNCS--GTAVDCSGRGLTEVPLDLPPDTTL 33
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
122-276 |
1.01e-04 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 44.84 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 122 ALNLSGNHLKEVCAGAFEHLPGLRRLDLSHNPLT-----------------NLSAFAFAGSNASVSAPSpLEELIL-NHI 183
Cdd:PLN00113 73 SIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgpipddifttssslrylNLSNNNFTGSIPRGSIPN-LETLDLsNNM 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 184 VPPEDQRQNGSFEGMVAFE-GMVAAALRSGLALRGLTRLE---LASNHFLF-LPRDL----------------------- 235
Cdd:PLN00113 152 LSGEIPNDIGSFSSLKVLDlGGNVLVGKIPNSLTNLTSLEfltLASNQLVGqIPRELgqmkslkwiylgynnlsgeipye 231
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 342187131 236 LAQLPSLRYLDLRNNSLVSLTYASFRNLTHLESLHLEDNAL 276
Cdd:PLN00113 232 IGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKL 272
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
142-252 |
1.72e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.43 E-value: 1.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 142 PGLRRLDLSHNPLTNLSAFAFAGsnasvsapspleelilnhivppedqrqngsfegmvafegmvaaalrsglaLRGLTRL 221
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKG--------------------------------------------------LSNLKVL 30
|
90 100 110
....*....|....*....|....*....|.
gi 342187131 222 ELASNHFLFLPRDLLAQLPSLRYLDLRNNSL 252
Cdd:pfam13855 31 DLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
240-274 |
3.86e-04 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 38.00 E-value: 3.86e-04
10 20 30
....*....|....*....|....*....|....*
gi 342187131 240 PSLRYLDLRNNSLVSLtyASFRNLTHLESLHLEDN 274
Cdd:pfam12799 1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGN 33
|
|
| LRRNT |
pfam01462 |
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ... |
62-90 |
5.01e-04 |
|
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.
Pssm-ID: 396168 [Multi-domain] Cd Length: 28 Bit Score: 37.22 E-value: 5.01e-04
10 20
....*....|....*....|....*....
gi 342187131 62 CPAACECSeaARTVKCVNRNLLEVPADLP 90
Cdd:pfam01462 2 CPVPCHCS--ATVVNCSDRGLTAVPRDLP 28
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
120-161 |
7.54e-04 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 37.22 E-value: 7.54e-04
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 342187131 120 LEALNLSGNHLKEVcaGAFEHLPGLRRLDLSHN-PLTNLSAFA 161
Cdd:pfam12799 3 LEVLDLSNNQITDI--PPLAKLPNLETLDLSGNnKITDLSDLA 43
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
98-252 |
1.42e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 40.42 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 98 LTGNQMTVLPAgaFARQPPLADLEALN--LSGNHLKEVCAGAFEHLPGLRRLDLSHNPLTNLSAFAFAGsnaSVSAPSPL 175
Cdd:cd00116 93 LGPDGCGVLES--LLRSSSLQELKLNNngLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAK---ALRANRDL 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 176 EELILnhivppedqRQNGsfegmVAFEGmVAAALRSGLALRGLTRLELASNHF-----LFLPrDLLAQLPSLRYLDLRNN 250
Cdd:cd00116 168 KELNL---------ANNG-----IGDAG-IRALAEGLKANCNLEVLDLNNNGLtdegaSALA-ETLASLKSLEVLNLGDN 231
|
..
gi 342187131 251 SL 252
Cdd:cd00116 232 NL 233
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
47-160 |
2.61e-03 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 40.15 E-value: 2.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 47 AFLASGSAQPPPAE---------RCPAACECSEAARTVK----CVNRN----------LLEVPADLPPYVRNLFLTGNQM 103
Cdd:PRK15387 155 SFLPATTAPQTPAEydavwsawrRAAPAEESRGRAAVVQkmraCLNNGnavlnvgesgLTTLPDCLPAHITTLVIPDNNL 234
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 342187131 104 TVLPAgafarQPPlaDLEALNLSGNHLKEVCAGAfehlPGLRRLDLSHNPLTNLSAF 160
Cdd:PRK15387 235 TSLPA-----LPP--ELRTLEVSGNQLTSLPVLP----PGLLELSIFSNPLTHLPAL 280
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
90-252 |
5.92e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 38.62 E-value: 5.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 90 PPYVRNLFLTGNQMTVLPAGAFARQ-PPLADLEALNLSGNHLKevCAGA---FEHLPG---LRRLDLSHNPLTNLSAFAF 162
Cdd:COG5238 207 NTTVTTLWLKRNPIGDEGAEILAEAlKGNKSLTTLDLSNNQIG--DEGVialAEALKNnttVETLYLSGNQIGAEGAIAL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187131 163 AgsnASVSAPSPLEELILNHIvppedqrqNGSFEGMVAF----------------------EGMV--AAALRSGlalRGL 218
Cdd:COG5238 285 A---KALQGNTTLTSLDLSVN--------RIGDEGAIALaeglqgnktlhtlnlayngigaQGAIalAKALQEN---TTL 350
|
170 180 190
....*....|....*....|....*....|....*...
gi 342187131 219 TRLELASNHFLFLPRDLLAQL----PSLRYLDLRNNSL 252
Cdd:COG5238 351 HSLDLSDNQIGDEGAIALAKYlegnTTLRELNLGKNNI 388
|
|
|