|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_FLVCR2 |
cd17456 |
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ... |
83-488 |
0e+00 |
|
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341014 Cd Length: 406 Bit Score: 782.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 83 RRWAVVLVFSCYSMCNSFQWIQYGSINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNC 162
Cdd:cd17456 1 RRWVIVLLFSSYSLCNAFQWIQYGIINNIFMHFYGVSSFAIDWLSMSYMLTYIPLIFPVAWLLDKRGLRVIALVGSALNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 163 LGAWVKLGSLKPHLFPVTVVGQLICSVAQVFILGMPSRIASVWFGANEVSTACSVAVFGNQLGIAIGFLVPPVLVPNIED 242
Cdd:cd17456 81 LGAWIKTGSARPDLFPVTVLGQLVCSVAQVFILGMPSRIASVWFGSSEVSTACSIGVFGNQLGVAIGFLLPPVLVPNIDD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 243 RDELAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALTSPDASYLGSIARLFKNLNFVLLVITYGLNAG 322
Cdd:cd17456 161 LDELAYHISIMFYGTAAVATLLFILVIIVFQEKPKIPPSQAQAAIQSIPSQDYSYLQSILRLLKNVNFILLVVSYGLNTG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 323 AFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKETTLVVYIMTLVGMVVYTFTLNLGHLW 402
Cdd:cd17456 241 CFYALSTLLNRMVIFHYPGEEVNAGRIGLTIVVAGMVGALISGIWLDRTKTYKQTTLAVYIMSLVGMVVYTFTLNLGHLW 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 403 VVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKPGNIFLCVFLTLGAA 482
Cdd:cd17456 321 VVFITAGTLGFFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSAQVFGIIFTISQGQIIDNFGTKAGNIFLCAFLLVGTI 400
|
....*.
gi 46396034 483 LTAFIK 488
Cdd:cd17456 401 LTALIK 406
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
83-488 |
0e+00 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 659.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 83 RRWAVVLVFSCYSMCNSFQWIQYGSINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNC 162
Cdd:cd17398 1 RRWIMLFLFCLYSMSNAFQWIQYAIISNIIVDYYGVSDTAVDWTSMIYMLTYIPLIFPATWLLEKYGLRVTVLLGSFLNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 163 LGAWVKLGSLKPHLFPVTVVGQLICSVAQVFILGMPSRIASVWFGANEVSTACSVAVFGNQLGIAIGFLVPPVLVPNIED 242
Cdd:cd17398 81 LGAWLKLFSSSPDLFWVAMAGQTICALAQVFILGIPPRLAAVWFGPDEVSTATAIGVFGNQLGVALGFVLPPLLVPNSEN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 243 RDELAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALTSPDASYLGSIARLFKNLNFVLLVITYGLNAG 322
Cdd:cd17398 161 KDEIGKGLSILFYGVAGICTALFILVIIFFKEKPPIPPSRAQAAAQELRSEDQSYLGSLKRLFKNKGFLLLLITYGINTG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 323 AFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKETTLVVYIMTLVGMVVYTFTLNLGHLW 402
Cdd:cd17398 241 VYYAISTLLNQMVLEYFPNEEVNAGWIGLTLVIAGLVGSVVAGIWLDKTKKYKETTIIVYILSFIGMVAFTFTLDLGSIW 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 403 VVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKPGNIFLCVFLTLGAA 482
Cdd:cd17398 321 VVFLTAGALGFFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASAQIFGIIFTLVMGALLDKVGALASNIVLSVALLLGTI 400
|
....*.
gi 46396034 483 LTAFIK 488
Cdd:cd17398 401 LTAFIK 406
|
|
| MFS_FLVCR1 |
cd17455 |
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ... |
83-488 |
0e+00 |
|
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341013 Cd Length: 407 Bit Score: 568.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 83 RRWAVVLVFSCYSMCNSFQWIQYGSINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNC 162
Cdd:cd17455 1 RRFAVLAVFSLYSLVNAFQWIQYSIITNIFTEFYGVSSGAIDWLSVVYMVAYVPLIFPATWLLDLKGLRVTALLGAGLNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 163 LGAWVKLGSLKPHLFPVTVVGQLICSVAQVFILGMPSRIASVWFGANEVSTACSVAVFGNQLGIAIGFLVPPVLVPNI-E 241
Cdd:cd17455 81 LGAWVKCASVRPDLFGVTMLAQVLCSVAQVFILGLPSRIASVWFGPREVSTACAVAVLGNQLGTAIGFLLPPVLVPNTvD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 242 DRDELAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALTSPDASYLGSIARLFKNLNFVLLVITYGLNA 321
Cdd:cd17455 161 DIDLMGHNISIMFYGTAAVSTLLFILTIIVFKEKPPLPPSQAQAVLQGIPSEDYSYKQSIINLFKNVPFVLLLISYGIMT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 322 GAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKETTLVVYIMTLVGMVVYTFTLNLGHL 401
Cdd:cd17455 241 GTFYSVSTLLNQMIITHYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLDLGYL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 402 WVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKPGNIFLCVFLTLGA 481
Cdd:cd17455 321 IVVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIIFTLIQGKLTTDYGPQAGNIFLCAWIFVGI 400
|
....*..
gi 46396034 482 ALTAFIK 488
Cdd:cd17455 401 ILTALIK 407
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
83-488 |
9.60e-118 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 353.24 E-value: 9.60e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 83 RRWAVVLVFSCYSMCNSFQWIQYGSINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNC 162
Cdd:cd17334 1 RRWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 163 LGAWVKLGSL-KPHLFPVTVVGQLICSVAQVFILGMPSRIASVWFGANEVSTACSVAVFGNQLGIAIGFLVPPVLVPNie 241
Cdd:cd17334 81 LGSVLKCIPLgQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVPP-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 242 dRDELAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALTSPDASYLGSIARLFKNLNFVLLVITYGLNA 321
Cdd:cd17334 159 -PKGTKKEFGAVFYGEFGFACLLLALVLALFPPKPKYPPSAASARQQNSEHVILELQKSISELLRNEPFVLLAVAFSIMM 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 322 GAFYALSTLLNRMVIwHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSktyKETTLVVYIMTLVGMVVYTFTLNL--- 398
Cdd:cd17334 238 GVFAGFSSVLAQILL-PFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRT---RMFKLIGLIILALGTVVCTFFMLLvdr 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 399 ----GHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKPGNIFLC 474
Cdd:cd17334 314 yglpYVTLAFYLLCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLGPTPTESKYLLWF 393
|
410
....*....|....
gi 46396034 475 VFLTLGAALTAFIK 488
Cdd:cd17334 394 ILCTVGSCLGALFF 407
|
|
| MFS_MFSD7 |
cd17399 |
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ... |
83-457 |
7.64e-71 |
|
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340957 Cd Length: 419 Bit Score: 232.16 E-value: 7.64e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 83 RRWAVVLVFSCYSMCNSFQWIQYGSINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNC 162
Cdd:cd17399 1 RRWFVLLVVCLLNCSNAMIWISFAPVADYTAEYYNVSLDAVNWLSLIYMIVSIPVGFVAMWLLDTLGLRTAIILGAWLNF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 163 LGAWVKLGSLKPHL-----FPVTVVGQLICSVAQVFILGMPSRIASVWFGANEVSTACSVAVFGNQLGIAIGFLVPPVLV 237
Cdd:cd17399 81 IGAVIRVISSLPFVdpsfrFPVLMTGQTLAAFAQPFILFLPTKLAALWFPDNQRAIANMLASMSNPLGVLLANLLSPLIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 238 PNIEDrdelAYHISIMFYIIGGVATLLLIlvIIVFKEKPKYPPSRAQslsyalTSPDASYLGSIARLFKNLNFVLLVITY 317
Cdd:cd17399 161 KSSED----IFLLLSIYTIPALIAVVLAT--FGVRSSVPPTPPSASA------AHESEPFFVGLKQLFKNKQYLILMLCF 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 318 GLNAGAFYALSTLLNRMVIWHYPGEEVnAGRIGLTIVIAGMLGAVISGIWLDRSKTYKETTLVVYIMTLVGMVVYTFTLN 397
Cdd:cd17399 229 GGGIGLFNALSTLLEQILCPSGYSNNF-AGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSR 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46396034 398 L-GHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQ 457
Cdd:cd17399 308 FpNQSVLLAVLCGLFGFFGFAIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIM 368
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
83-477 |
3.62e-49 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 173.64 E-value: 3.62e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 83 RRWAVVLVFSCYSMCNSFQWIQYGSINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNC 162
Cdd:cd17397 1 RRWYILLVFSLLAFTQGAVWNTWGPIADSAKPAFGWSDSDIALLANWGPIGFVPTFFFMAWLMDVKGLRIAVLSSAFLVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 163 LGAWVKLGSLKPHLFPVTV-VGQLICSVAQVFILGMPSRIASVWFGANEVSTACSVAVFGNQLGIAIGFLVPPVLVpnie 241
Cdd:cd17397 81 AGTGLRCIPVPNHLATWLIhIGQFLNGLAGPVAMAAAPFLSATWFPPNQRATATAIASIFNYLGGAASFLIGPLVL---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 242 drdelayhisimFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSlsyaltSPDASYLGSIARLFKNLNFVLLVITYGLNA 321
Cdd:cd17397 157 ------------MYLEFGWSALIFLAMLIYFPSKPPTPPSVSAS------TQRLSYKSGILSLLKNKRFWLIALAYGIPT 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 322 GAFYALSTLLNrmVIWHYPG-EEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTY-KETTLVVYIMTLVGMVVYTFTLNL- 398
Cdd:cd17397 219 GVYAGWSGVLD--VNLTPFGvSQVEAGWIGFYSTVAGCVGGIIVGRFADRFGGRmKLILLLLFSGATGSFLWFTLICLKl 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 399 --GHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTIsqGQIIDNYGTK------PGN 470
Cdd:cd17397 297 lpFSTVSLYTSCILLGVFLNGSVPLFYELAVEAAYPVPEGITSGVLTFLNNVFGLVFLL--ILIIPNIGTSwmnwclLGS 374
|
....*..
gi 46396034 471 IFLCVFL 477
Cdd:cd17397 375 CLLSVPL 381
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
91-487 |
1.70e-30 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 122.54 E-value: 1.70e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 91 FSCYSMCNSFQWIQYGSINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNCLGAwvkLG 170
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGA---LL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 171 SLKPHLFPVTVVGQLICSVAQVFILGMPSRIASVWFGANEVSTACSVAVFGNQLGIAIGFLVPPVLVpniedrDELAYHI 250
Cdd:cd06174 78 FAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA------SSLGFGW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 251 SIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYAltspdaSYLGSIARLFKNLNFVLLVITYGLNAGAFYALSTL 330
Cdd:cd06174 152 RAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSK------SVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 331 LNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTykeTTLVVYIMTLVGMVVYTFTLNLGHLWVVFITAGT 410
Cdd:cd06174 226 LPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG---RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 46396034 411 MGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGqIIDNYGTKPGNIFLCVFLTLGAALTAFI 487
Cdd:cd06174 303 LGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAG-FLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
82-497 |
9.81e-29 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 117.67 E-value: 9.81e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 82 RRRWAVVLVFSCYSMCNSFQWIQYGSINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALN 161
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 162 CLGAwvkLGSLKPHLFPVTVVGQLICSVAQVFILGMPSRIASVWFGANEVSTACSVAVFGNQLGIAIGFLVPPVLVpnie 241
Cdd:COG2223 81 GIGL---LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI---- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 242 drdeLAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLsyaltspdasyLGSIARLFKNLNFVLLVITYGLNA 321
Cdd:COG2223 154 ----AAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKAS-----------LRDQLEALRDPRFWLLSLLYFGTF 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 322 GAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKeTTLVVYIMTLVGMVVYTFTlnLGHL 401
Cdd:COG2223 219 GSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRR-VLLIVFALMALGLLLLALA--LGSL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 402 WVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGT-KPGNIFLCVFLTLG 480
Cdd:COG2223 296 WLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSyTAAFLVFAVLALVA 375
|
410
....*....|....*..
gi 46396034 481 AALTAFIKADLRRQKAN 497
Cdd:COG2223 376 LVLTLLLYRRPRRAAAA 392
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
79-493 |
2.48e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 101.49 E-value: 2.48e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 79 KVSRRRWAVVLVFSCYSMCNSFQWIQYGSINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTG- 157
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGl 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 158 ---SALNCLGAWVklgslkpHLFPVTVVGQLICSVAQVFILGMPSRIASVWFGANEVSTACSVAVFGNQLGIAIGFLVPP 234
Cdd:COG2271 83 llwGLATLLFGFA-------TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 235 VLVPniedrdelAYHISIMFYIIGGVATLLLILviivfkekpkyppsraqslsyaltspdasylgsiarlfknlNFVLLV 314
Cdd:COG2271 156 WLLA--------AFGWRAAFLILGLPGLLLALL-----------------------------------------RFWLLA 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 315 ITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRskTYKETTLVVYIMTLVGMVVYTF 394
Cdd:COG2271 187 LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR--LGRRRKLVLAIGLLLAALALLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 395 TLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKPGNIFLC 474
Cdd:COG2271 265 LALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLA 344
|
410
....*....|....*....
gi 46396034 475 VFLTLGAALTAFIKADLRR 493
Cdd:COG2271 345 ALALLAALLALLLLRETRK 363
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
81-450 |
2.51e-20 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 92.34 E-value: 2.51e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 81 SRRRWAVVLVFSCYSMCNSFQWIQYGSINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSAL 160
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 161 NCLGAWvkLGSLKPHlFPVTVVGQLICSVAQVFILGMPSRIASVWFGANEVSTACSVAVFGNQLGIAIGFLVPPVLVPni 240
Cdd:COG2814 85 FALGSL--LCALAPS-LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 241 edrdelAYHISIMFYIIGGVATLLLILVIIVFKEkpkyppsraqslsyALTSPDASYLGSIARLFKNLNFVLLVITYGLN 320
Cdd:COG2814 160 ------LFGWRWVFLVNAVLALLALLLLLRLLPE--------------SRPAARARLRGSLRELLRRPRLLLLLLLAFLL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 321 AGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKeTTLVVYIMTLVGMVVYTFTlnlGH 400
Cdd:COG2814 220 GFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR-LLLIGLLLLALGLLLLALA---GS 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 46396034 401 LWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFG 450
Cdd:COG2814 296 LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
90-454 |
4.99e-19 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 88.24 E-value: 4.99e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 90 VFSCYSMCNSFQWIQYGSINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNCLGAWVkl 169
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 170 gSLKPHLFPVTVVGQLICSVAQVFILGMPSRIASVWFGANEVSTACSVAVFGNQLGIAIGFLVPPVLVpniedrdeLAYH 249
Cdd:pfam07690 79 -LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA--------SLFG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 250 ISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALTSPdasylgsiARLFKNLNFVLLVITYGLNAGAFYALST 329
Cdd:pfam07690 150 WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA--------WKALLRDPVLWLLLALLLFGFAFFGLLT 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 330 LLNRMVIwHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKeTTLVVYIMTLVGMVVYTFTLNLGHLWVVFITAG 409
Cdd:pfam07690 222 YLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRR-RLLLALLLLILAALGLLLLSLTLSSLWLLLALL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 46396034 410 TMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFT 454
Cdd:pfam07690 300 LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
216-504 |
1.55e-14 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 75.71 E-value: 1.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 216 SVAVFGNQLGIAIGFLVPPVLVPNIEDRDELAYHisIMFYIIGGVATLLLILVIIVFKEKPKYPPSRaqslsyaltspdA 295
Cdd:COG2211 150 SWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYR--LTALIFAVLGLLAFLLTFFGTKERPVPEEEK------------V 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 296 SYLGSIARLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDR-SKty 374
Cdd:COG2211 216 SLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRfGK-- 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 375 KETTLVVYIMTLVGMVVYTFtLNLGHLWVVFITAGTMGFFMTGYLPLGF-------EFAVELTYPESEGISSGLLNISAQ 447
Cdd:COG2211 294 KKAFIIGLLLAALGLLLLFF-LGPGNLWLLLVLAALAGIGLGAILVLPWamladvvDYDEWKTGRRREGLYFGIFTFAIK 372
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 46396034 448 VFGIIFTISQGQIIDNYGTKPGN---------------IFLCVFLTLGAALTAFIKADLRRQKANKETLENK 504
Cdd:COG2211 373 LGQALAGALAGLLLALFGYVAGAaqspsaltgirllffLLPAVLLLLAALLLLFYPLTRERHAEIRAELAAR 444
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
82-494 |
6.74e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 67.19 E-value: 6.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 82 RRRWAVVLVFSCYSMCNSFqwiqYGSINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALN 161
Cdd:COG0738 8 RALIAIYLLFFLWGFATAL----WGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 162 CLGAwvkLGSLKPHLFPVTVVGQLICSVAQVFIL-GMPSRIASVwfGANEVSTACSVAVFGNQLGIAIGFLVPPVLVpni 240
Cdd:COG0738 84 ALGL---LLFALAPSYPLLLLALFLLGLGLGLLDvAANPYVAAL--GPETAASRLNLLHAFFSLGALLGPLLGGLLI--- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 241 edRDELAYHISIMFYIIGGVATLLLILVIIVfkekpKYPPSRAQSlsyaltSPDASYLGSIARLFKNLNFVLLVITYGLN 320
Cdd:COG0738 156 --LLGLSLSWHLPYLILAVLLLLLALLFLRS-----KLPEIEEEE------EEAAGSAASLKSLLKNPRLLLGGLAIFLY 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 321 AGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKettlVVYIMTLVGMVVYTFTLNLGH 400
Cdd:COG0738 223 VGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVR----LLRLSALLAAVGLLLALLAPG 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 401 LWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLnISAQVFGIIFTISQGQIIDNYGTKPGNIFLCVFLTLG 480
Cdd:COG0738 299 PWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVL-IMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLI 377
|
410
....*....|....
gi 46396034 481 AALTAFIKADLRRQ 494
Cdd:COG0738 378 LLLALALKRKRRKK 391
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
116-485 |
7.76e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 66.88 E-value: 7.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 116 YGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSAlnCLGAWVKLGSLK---PHLFPVTVVGQLICSVAQv 192
Cdd:cd17475 26 LHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLL--LMGAAALLMALVgsyPVLLVLLFLVGAGYGSVQ- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 193 filGMPSRIASVWFGANEVSTACSVAVFGNQLGIAIGFLVPPvlvpniedrdELAYHISI-MFYIIGGVATLLLILVIIV 271
Cdd:cd17475 103 ---PGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLP----------PLALHYGWrAAFVVAGLVSILAAVLFWL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 272 FKEKPKYPPSRAQSLSYALTSpdasylgsIARLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGL 351
Cdd:cd17475 170 FYREPPAASAATESASTLLRS--------LKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 352 TIVIAGMLGAVISGIWLDR--SKTYKETTLVVYIMTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVEL 429
Cdd:cd17475 242 VAQLGGALGRIGLGRVSDRvfGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAES 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 46396034 430 TYPESEGISSGLLNISAQVFGIIFTISQGQIID-NYGTKPGNIFLCVFLTLGAALTA 485
Cdd:cd17475 322 AGPEQAGTALGLANTINFIGIAIGPPLFGLLVDaTHSYAPAWLALALLLVLAALLLL 378
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
81-430 |
9.77e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 66.82 E-value: 9.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 81 SRRRWAVVLVFSCYSMCNSFQWIQYGSINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSAL 160
Cdd:COG2807 13 RAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 161 NCLGAWvkLGSLKPHlFPVTVVGQLICSVAQVFILGMPSRIASVWFgANEVSTACSVAVFGNQLGIAIGFLVPPVLVPni 240
Cdd:COG2807 93 LAAGLL--LRSLAPS-VALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAA-- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 241 edrdelAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSlsyaltspdasylGSIARLFKNLNFVLLVITYGLN 320
Cdd:COG2807 167 ------ALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAA-------------ASLRSLWRSPLAWLLTLFFGLQ 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 321 AGAFYALSTLLNRMVI-WHYPGEEvnAGRIGLTIVIAGMLGAVISGIWLDRSKTYKETTLVVYIMTLVGMVVYTFT-LNL 398
Cdd:COG2807 228 SLLYYAVVAWLPPILRdAGLSAAT--AGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLApGSL 305
|
330 340 350
....*....|....*....|....*....|..
gi 46396034 399 GHLWVVFITAGTMGFFmtgylPLGFEFAVELT 430
Cdd:COG2807 306 PWLWAVLLGLGQGGLF-----PLALTLIGLRA 332
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
116-485 |
6.73e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 64.11 E-value: 6.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 116 YGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNCLGAWvkLGSLKPHlFPVTVVGQLICSVAQVFIL 195
Cdd:cd17324 29 FGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNL--LAALAPS-FALLLLARALAGLAHGGFW 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 196 GMPSRIASVWFGANEVSTACSVAVFGNQLGIAIGFLVPPVLvpniedrdELAYHISIMFYIIGGVATLLLILVIIVFkek 275
Cdd:cd17324 106 AIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL--------GQLLGWRAAFLAIAVLALLAALLLWRLL--- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 276 PKYPPSRAQSLsyaltspdaSYLGSIARLFKNLNFVLLVITYGLNAGAFYA----LSTLLNRMViwHYPGEEVnagrIGL 351
Cdd:cd17324 175 PSLPPKKPGSL---------GLLSSLLLLLRNPRLRLAYLITFLLFGGFFAlytyLAPFLTDVP--GFSSSAI----IGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 352 TIV--IAGMLGAVISGIWLDRSKTYKettlVVYIMTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVEL 429
Cdd:cd17324 240 LLLfgVAGVVGSPLAGRLADRGGRRA----LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 46396034 430 TyPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKPGNIFLCVFLTLGAALTA 485
Cdd:cd17324 316 A-PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
117-487 |
1.50e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 62.97 E-value: 1.50e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 117 GVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRT----IALTGSALNCLGAWVklgslkphlfpVTVVGQLICSvaqv 192
Cdd:cd17319 34 GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKvlavSMLLWSLFTALTGFA-----------TSLTSLYVLR---- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 193 FILGMP--------SRIASVWFGANEVSTACSVAVFGNQLGIAIGflvPPVLVPNIEDRDELAyhisiMFYIIGGVATLL 264
Cdd:cd17319 99 FLLGVAeagffpgaIKALAEWFPARERGRATGLFNSGAPLGAAIG---PPLSGWLLLLFGWRW-----AFIIEGLLGLLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 265 LILVIIVFKekpkyppsraqslsyaltspdasylgsiarlfknlNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEV 344
Cdd:cd17319 171 AVLWWFYLR-----------------------------------QVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLK 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 345 NAGRIGLTIVIAGMLGAVISGIWLDRSKTYKETTLVVyIMTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFE 424
Cdd:cd17319 216 QVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVII-IGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWS 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46396034 425 FAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIID-NYGTKPGNIFLCVFLTLGAALTAFI 487
Cdd:cd17319 295 LPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDaTGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
111-488 |
2.61e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 62.21 E-value: 2.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 111 IFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNCLG----AWVklgslkpHLFPVTVVGQLI 186
Cdd:cd17325 21 LYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVStllfAFA-------TSYWQLLLARFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 187 CSVAQVFIlgMPSRIASV--WFGANEVSTACSVAVFGNQLGIAIGFLVPPVLVPniedrdelAYHISIMFYIIGGVATLL 264
Cdd:cd17325 94 QGLASAAV--WPAAMALIadIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD--------ALGYRAPFLVCAALALLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 265 LILVIIVFKEKPKYPPSRAQSLSYALTspdasylgSIARLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYpgeEV 344
Cdd:cd17325 164 LVLALLLLPEPRPPPNKRAVSAARLRS--------GLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG---GL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 345 NAGRIGLTI---VIAGMLGAVISGIWLDRsKTYKETTLVVYIMTLVGMVVYTFTLNLGHLWVVFITAG-TMGFFMTGYLP 420
Cdd:cd17325 233 SPAQIGLLFgaqGLASALSQPPAGKLSDR-IGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGlGLGLVFPATLA 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 46396034 421 LgfefAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKPGNIFLCVFLTLGAALTAFIK 488
Cdd:cd17325 312 L----LADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
141-486 |
3.69e-10 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 61.90 E-value: 3.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 141 VAWLLEKFGLRTIALTGSALNCLGAWVKLGSLKPH----LFPVTVVGQLICSVAqvfilGMPSRIASVWFGANEvSTACS 216
Cdd:cd17355 58 VGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWqlylLWGLLGGGGAGTLAA-----VAFATVAAWWFERRR-GLALG 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 217 VAVFGNQLGiaiGFLVPPVLVPNIEdrdelAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAqslsyALTSPDAS 296
Cdd:cd17355 132 ILTAGGGLG---SLVFLPLGAALIE-----AFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRA-----YDDASPAS 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 297 YLGSIARLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLtIVIAGMLGAVISGIWLDR-SKTYk 375
Cdd:cd17355 199 PGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALAL-IGLFNIVGRLLSGWLGDRySPRR- 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 376 eTTLVVYIMTLVGMVVYTFTLNLGHLWVVFitAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTI 455
Cdd:cd17355 277 -LLAASYALRALGLALLLLLPFPPLALLLF--AALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPW 353
|
330 340 350
....*....|....*....|....*....|.
gi 46396034 456 SQGQIIDNYGTKPGNIFLCVFLTLGAALTAF 486
Cdd:cd17355 354 LGGLLYDRTGSYTAAWALAVALGLIAALLVL 384
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
212-486 |
1.05e-09 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 60.33 E-value: 1.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 212 STACSVAVFGNQLGIAIGFLVPPVLVPNIEDRDELAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALT 291
Cdd:cd17313 140 SKANGIINFMGGLGGVLGYLLGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLG 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 292 SPDASYLGSIARLFKNLNFVLLVITYGLNA-GAFYALSTLLNRMVIWH-------YPGEEVNAGRIGLTIV-IAGMLGAV 362
Cdd:cd17313 220 EVLKSLLKLLKIMPRSLLRLLLVIFFWWIAfFPFELFFTDYMGEEVYHgtsaassHYGAGVRMGAWGLLIFsLAFLIFSL 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 363 ISGIWLDRSKTyKETTLVVYIMTLVGMVVYTFTLNLGHLWVVFITAGtMGFFMTGYLPlgFEFAVELT--YPESEGISSG 440
Cdd:cd17313 300 PIGKLGKKIGR-KKVYLIGLVLFAVGMALMALVHNVTVALVLFALGG-IGWATININP--YPLVSDYHseSGRGQGTDTG 375
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 46396034 441 LLNISAQVFGIIFTISQGQIIDNYGTKPGNIFLCVFLTLGAALTAF 486
Cdd:cd17313 376 LLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGALF 421
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
85-487 |
1.89e-08 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 56.41 E-value: 1.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 85 WAVVLV-----FSCYSMCNSFqwiqyGSINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSA 159
Cdd:cd17352 2 WVVVFAsflvnFFTDGILNSF-----GVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 160 LNCLGAWvkLGSLKPHLFPVTVVGQLICSVAQVFILGMPSRIASVWFgANEVSTACSVAVFGNQLGiaiGFLVPPVLvpn 239
Cdd:cd17352 77 LAALGLL--LSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVG---TFVFPPLL--- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 240 iedrdelayhiSIMFYIIGGVATLLLILVIIVFkekpkyppsraqslsyaltspdASYLGSIARLFKNLNFVLLVITYGL 319
Cdd:cd17352 148 -----------RYLLDNYGWRGALLILGGLCLN----------------------LCVCGLLLRLLKDPTFVLLALGVSF 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 320 NAGAFYALSTLLNRMVIWHypGEEVNAGRIGLTIV-IAGMLGAVISGIWLDRSKTYKeTTLVVYIMTLVGMVVYTFTLnL 398
Cdd:cd17352 195 AMLGFFVPFVYLPSYAKSL--GIDESDAAFLLSIIgISDIVGRILLGLLADKPRIGR-LYLYIFTLLILGLSLLAFPL-A 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 399 GHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKPGNIFLCVFLT 478
Cdd:cd17352 271 TTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACL 350
|
....*....
gi 46396034 479 LGAALTAFI 487
Cdd:cd17352 351 LLSGVLLFL 359
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
65-277 |
6.69e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.83 E-value: 6.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 65 AHPSSSGPEDLSVIKVSRRRWAVVLVFSCYSMCNSFQWiqyGSINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWL 144
Cdd:COG2211 211 EEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVA---ALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 145 LEKFGLRTIALTGSALNCLGAWVkLGSLKPHLFPVTVVGQLICSVAQVFILGMP-SRIASV------WFGANEVSTACSV 217
Cdd:COG2211 288 AKRFGKKKAFIIGLLLAALGLLL-LFFLGPGNLWLLLVLAALAGIGLGAILVLPwAMLADVvdydewKTGRRREGLYFGI 366
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 46396034 218 AVFGNQLGIAIG-FLVPPVL-----VPNIEDRDELAYHISIMFYIIGGVATLLLILVIIVFKEKPK 277
Cdd:COG2211 367 FTFAIKLGQALAgALAGLLLalfgyVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRE 432
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
116-487 |
2.38e-06 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 49.88 E-value: 2.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 116 YGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNCLGAWVKLGSLKPHLFpvtvvgqLICSVAQVFIL 195
Cdd:cd17320 29 LGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQL-------LIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 196 GMPSRIASV----WFGANEVStacsvAVFGNqlgIAIGFLVPPVLVPNIEDRDELAYHISIMFYIIGGVATLLLILVIIV 271
Cdd:cd17320 102 AAGSVVARAivrdLYSGAELA-----KIFSL---LMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLF 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 272 FKEKPKYPPSRAQSlsyaltspdASYLGSIARLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGL 351
Cdd:cd17320 174 LPETLPEEKRKPLL---------SSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 352 TIVIAGMLGAVISGIWLDRSKTYK--ETTLVVYIMTLVGMVVYTFTLNLGHLWVV---FITAGTMGFFMtgylPLGFEFA 426
Cdd:cd17320 245 LNAIALILGSLLNGRLVRRFGPRRllRLGLLLLLAAALVLLLAALLGGLSLWPLVaplFLIFFGFGLIF----PNATSLA 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46396034 427 VELtYPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKPGniFLCVFLTLGAALTAFI 487
Cdd:cd17320 321 LEP-FPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMG--LLILVLGLLALLLLIL 378
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
116-486 |
2.71e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 49.56 E-value: 2.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 116 YGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNCLGAWVkLGSLKPHLFPVTVVGQLICSVAQVFIL 195
Cdd:cd17341 29 LGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA-LALAVSSYWGLLVLGFLLGFAGANFAS 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 196 GMPSriASVWFGANEVSTACSVAVFGNQLGIAIG-FLVPPVLVPNIEDRDELAYHISIMFYIIggVATLLLILVIIVFKE 274
Cdd:cd17341 108 GQPW--ASFWFPKEKIGGAAGGIAGAGNMGVAVSqLLAPLIAGAIVFDGGFVGWRNAFFVPGI--LLAIAAVLVLLFGDD 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 275 KPKYPPSRAQSLSyaltspdasylgSIARLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIV 354
Cdd:cd17341 184 LPTGKASALEFLK------------VQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFP 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 355 IAGMLGAVISGIWLDRSKTYKeTTLVVYIMTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFA-VELTYPE 433
Cdd:cd17341 252 LAGALARPAGGWLSDRFGGRR-RLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSVFRmVPFIFRR 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 46396034 434 SEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKPGNIFLCVFLTLGAALTAF 486
Cdd:cd17341 331 ELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVW 383
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
83-487 |
7.09e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 48.38 E-value: 7.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 83 RRWAVVLVFSCYSMCNSFQWIqYGSINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNC 162
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYA-WSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 163 LGaWVkLGSLKPHLFPVTVVGQLICSVAQVFILGMPSRIASVWFGANE-VSTACSVAVFGnqLGiAIGFLVPPVLVPNie 241
Cdd:cd17353 80 LG-FI-LSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRgLATGIVIAGFG--LG-SLIFSPLIAYLIN-- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 242 drdelAYHISIMFYIIGGVATLLLILVIIVFKEKPK-YPPSRAQSLSYALTSPDASYlgSIARLFKNLNFVLLVITYGLN 320
Cdd:cd17353 153 -----TVGVPTTFLILGIIFLIIIVIGAFLIRDPPKgWVPPGVDPLANNAENSPRDY--TPREMLRTPTFWLLWLMFFLN 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 321 AGAFYALSTLLNRMVIwHYPGEEVNAGRIGLTIV-IAGMLGAVISGIWLDRSKtYKETTLVVYIMTLVGMVvyTFTLNLG 399
Cdd:cd17353 226 ATAGLMLIGQAKPIGQ-EFAGLDAGIAALAVSILsIFNGGGRPFWGWLSDKIG-RKNTLSIAFLIQGVAMF--LLPFIGS 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 400 HLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKPGNIFLCVFLTL 479
Cdd:cd17353 302 VAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLV 381
|
....*...
gi 46396034 480 GAALTAFI 487
Cdd:cd17353 382 ALALALLL 389
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
199-486 |
1.16e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.47 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 199 SRIASVWFGANeVSTACSVAVFGNQLGIAIG-FLVPPVLVPniedrdeLAYHISIMFYIIGGVATLLLILViiVFKEKPK 277
Cdd:cd17478 106 ARLASQAAGGR-RGLAMSIFSVGGNLGFALGpLIAAALVAL-------FGGLGLLILLIIPGLAVALLLLR--LRPLKKP 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 278 YPPSRAQSLSYALTspdasylgsiaRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIwHYPGEEVNAGRIGLTIVIAG 357
Cdd:cd17478 176 EAKKAAAKSSARST-----------LKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLV-QRGYSLVFAGLLLSLFLFAG 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 358 MLGAVISGIWLDRsktYKETTlvVYIMTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTyPESEGI 437
Cdd:cd17478 244 AIGTLIGGPLSDR---FGRRR--VIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELL-PGNVGL 317
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 46396034 438 SSGLLNISAQVFGIIFTISQGQIIDNYGTKPGnIFLCVFLTLGAALTAF 486
Cdd:cd17478 318 ASGLMMGLSFGLGGIGAPVLGALADAFGLESV-LLILALLPLLGALLAF 365
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
65-272 |
2.87e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 43.36 E-value: 2.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 65 AHPSSSGPEDLSVIKVSRRRwaVVLVFSCYSMCNsfQWIQYG---SINNIFMHFYGVSAFAIDWLSMCYMLTYIPLLLPV 141
Cdd:cd17490 175 REKKPVLTELKELLSVLKDK--KLLFFSLLAILQ--QMITFSttfGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLS 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 142 AWLLE-KFGLRTIALTGSALncLGAWVKLGSLKPHLFPVTVVGQLI-CSVAQVFILGMPSRIASVwfGANEVSTAcsVAV 219
Cdd:cd17490 251 GTLFYkKLGERNTIIIGFLL--LGAYCFLIPFAPNLTLLYLLQALNgFGTGILFPLLMSLSIEGV--PAEQRSTA--MGF 324
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 46396034 220 FgnQLGIAIGFLVPPVLVPNIEDrdelAYHISIMFYIIGGVATLLLILVIIVF 272
Cdd:cd17490 325 F--QAIYALGMFLGPVLVGIISE----AFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
134-479 |
2.35e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 40.50 E-value: 2.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 134 YIPLLLPVAWLLEKFGLRTIaltgsalncLGAWVKLGSLKPHLFPVTVVGQLICSVAQVFILGMPSRIASV--------W 205
Cdd:TIGR00894 89 QIIIQIPVGYLAGKYVFKWS---------IGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPathkiivkW 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 206 FGANEVSTACSVAVFGNQLGIAIGFLVPPVLVpniedrdELAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQS 285
Cdd:TIGR00894 160 APPKERSRLLGMSTSGFQLGTFIFLPISGWLC-------ESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKF 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 286 LSYALTSPDASYLGS------IARLFKNLNFVLLVityglnaGAFYALSTLLNRMVIWHypgEEVNAGRIGLTIVIAG-- 357
Cdd:TIGR00894 233 EKKYINSSLQGQKGStrqslpIKAIPKSLPVWAIW-------FAIFGHFWLYTILPTYL---PTFISWVLRVSGKENGll 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 358 ----MLGAVISGIW------LDRSKTYKETTLVVYIMTLVG------MVVYTFTLNLGHLWVVFIT---AGTMGFFMTGY 418
Cdd:TIGR00894 303 sslpYLFAWLCSIFagyladFLKSSKTLSLTAARKIFNGIGglgpgiFAYALPYLSAAFYLTIIILtlaNAVSSGPLAGV 382
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46396034 419 LPLGFEFAveltyPESEGISSGLLNISAQVFGIIFTISQGQIIDnygTKPGNIFLCVFLTL 479
Cdd:TIGR00894 383 LINSLDLA-----PRFLGFIKGITGLPGFIGGLIASTLAGNILS---QDSKNVWLIVFLIM 435
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
206-427 |
2.39e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 40.30 E-value: 2.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 206 FGANEVSTACSVAVFGNQLGIAIGFLVPPVLVpniedrdELAYHISIMFYIIGGVATLLLILVIIVFKEKPKYPPSRAQS 285
Cdd:cd17328 116 FPKEKRTRALGVFYFAIPLGSGLGYVVGGLVA-------QATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVM 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 286 LSYALTSpdasYLGSIARLFKNLNFVLLVI-----TYGLNAGAFYALSTLLNRMVIWHYPGEEVnAGRIGLTIVIAGMLG 360
Cdd:cd17328 189 AKSTATS----FLADLKALAKNPSFILSTLgftavSFVTGALAFWAPTFFLRAFGVGDLSSADV-GLIFGAITCIAGVLG 263
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 46396034 361 AVISGIWLDRSKTYKETTLVvyIMTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAV 427
Cdd:cd17328 264 VLLGGILADRLRRKTPRADP--LVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAP 328
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
55-229 |
6.64e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.94 E-value: 6.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 55 PSALAQPSGLAHPSSSGPEDLSVIKVSRRRWAVVLVFscysmCNSFQWIQYGSINNIFMHFYGVSAFAIDWLSMCYMLTY 134
Cdd:pfam07690 174 PPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALL-----LFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLG 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 135 IPLLLPVAWLLEKFGLRTIALTGSALNCLGAWVKLGSLKPHLFPVTVVGQLICSVAQVFILGMPSRIASVWFGANEVSTA 214
Cdd:pfam07690 249 AIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTA 328
|
170
....*....|....*
gi 46396034 215 CSVAVFGNQLGIAIG 229
Cdd:pfam07690 329 SGLYNTAGSLGGALG 343
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
116-464 |
7.47e-03 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 38.90 E-value: 7.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 116 YGVSAFAIDWLSMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNCLGAWvkLGSLKPHLFPVtvvgqLICSVAQVFIL 195
Cdd:TIGR00711 32 LGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSL--LCGVAPNLELM-----IIFRVIQGFGG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 196 GM--PSRIASVWFGANEVSTACSVAVFGnqlgiaIGFLVPPVLVPNIEDRDELAYHISIMFYIIGGVATLLLILVIIVFK 273
Cdd:TIGR00711 105 GPliPLSFSTLLNIYPPEKRGRAMAIWG------LTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 274 EKPKYPPSRAQSLSYALTSPD------------------------ASYLGSIA------------------RLFKNLNFV 311
Cdd:TIGR00711 179 RDKPAASENFDFLGLLLLSVGlgsllyglsegpergwfdsneiliLSITGLVAiiafvvweltddnplvdlRLFKYRNFT 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 312 L-----LVITYGLnAGAFYALSTLLNRMViwHYPgeevnAGRIGLTIV---IAGMLGAVISGIWLDRSKTYKETTLVVyI 383
Cdd:TIGR00711 259 IgcvymSLLGLGL-YGSFYLLPLYLQQVL--GYT-----ALQAGLHILpvgLAPMLSSPIAGRMGDKIDPRKLVTIGL-I 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 384 MTLVGMVVYTFTLNLGH-----LWVVFITAGTMGFFMtgyLPLGfEFAVELTYPESEGISSGLLNISAQVFGIIFTISQG 458
Cdd:TIGR00711 330 LYAVGFYWRAFTFTPDTpflaiALPQFIRGFGMGCFF---MPLT-TIALSGLPPHKIARGSSLSNFTRQLGGSIGTALIT 405
|
....*.
gi 46396034 459 QIIDNY 464
Cdd:TIGR00711 406 TILTNR 411
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
309-486 |
8.11e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.74 E-value: 8.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 309 NFVLLVITYGLNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRsKTYKETTLVVYIMTLVG 388
Cdd:cd17316 178 RTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR-IGRKKTLVIGLILSGIL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46396034 389 MVVYtFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQVFGIIFTISQGQIIDNYGTKP 468
Cdd:cd17316 257 ALPL-FYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTG 335
|
170
....*....|....*...
gi 46396034 469 GNIFLCVFLTLGAALTAF 486
Cdd:cd17316 336 VPALILALLAIVALIVAL 353
|
|
| |
