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Conserved domains on  [gi|20139103|sp|Q99466|]
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RecName: Full=Neurogenic locus notch homolog protein 4; Short=Notch 4; Short=hNotch4; Contains: RecName: Full=Notch 4 extracellular truncation; Contains: RecName: Full=Notch 4 intracellular domain; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1619-1823 4.50e-40

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 151.26  E-value: 4.50e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1619 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrSRQTAVDART 1698
Cdd:COG0666   72 LLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL-EAGADVNAQD 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1699 EDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREG 1778
Cdd:COG0666  151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 20139103 1779 AVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAG 1823
Cdd:COG0666  231 NLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1431-1515 2.23e-29

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


:

Pssm-ID: 411988  Cd Length: 92  Bit Score: 113.26  E-value: 2.23e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1431 AVHPHAGTAPP---ANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQsaPHRRRPPLGED 1507
Cdd:cd21705    7 AVTVEEAEKDPqlvAAQLPWPLVCSSVAGVLALVLGALLGVQLIRRRQREHGALWLPPGFARHRDPN--PHRRREPVGED 84


                 ....*...
gi 20139103 1508 SIGLKALK 1515
Cdd:cd21705   85 AIGLKPLK 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 432-473 4.22e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 4.22e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 20139103  432 DLDECLMaqqgPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCE 473
Cdd:cd00054    1 DIDECAS----GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1249-1285 5.26e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 50.60  E-value: 5.26e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 20139103   1249 PACTPAYdqyCHDHFHNGHCEKGCNTAECGWDGGDCR 1285
Cdd:pfam00066    2 PNCPYPY---CWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 551-587 1.58e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.58e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 20139103  551 DIDECRS-SPCANGGQCQDQPGAFHCKCLPGFEGPRCQ 587
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 314-353 5.18e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 5.18e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 20139103  314 DVDECETQGPphCRNGGTCQNSAGSFHCVCVSGWGGTSCE 353
Cdd:cd00054    1 DIDECASGNP--CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1211-1246 8.40e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.14  E-value: 8.40e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 20139103   1211 WKGCPsHSRCWLLFRDGQCHPQCDSEECLFDGYDCE 1246
Cdd:pfam00066    1 WPNCP-YPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA pfam07645
Calcium-binding EGF domain;
194-225 1.94e-06

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.08  E-value: 1.94e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 20139103    194 DVNECFQDPGPCPKGTSCHNTLGSFQCLCPVG 225
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 515-549 2.85e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.85e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 20139103  515 NECASA-PCLNHADCHDLLNGFQCICLPGFSGTRCE 549
Cdd:cd00054    3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 970-1004 3.64e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.64e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 20139103  970 DACQSQ-PCHNHGTCTPKPGGFHCACPPGFVGLRCE 1004
Cdd:cd00054    3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 769-803 1.12e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 1.12e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 20139103  769 DYCVSA-PCFNGGTCVNRPGTFSCLCAMGFQGPRCE 803
Cdd:cd00054    3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 590-625 2.45e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.45e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 20139103  590 VDECLS-DPCPVGASCLDLPGAFFCLCPSGFTGQLCE 625
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 475-511 5.69e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 5.69e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 20139103  475 DHNECLSQ-PCHPGSTCLDLLATFHCLCPPGLEGQLCE 511
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1168-1204 1.44e-04

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 40.59  E-value: 1.44e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 20139103   1168 PRCQKPGakgCEGRSGDGACDAGCSGPGGNWDGGDCS 1204
Cdd:pfam00066    2 PNCPYPY---CWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 931-965 2.82e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 2.82e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 20139103  931 VNPCESR-PCQNGATCMAQPSGYLCQCAPGYDGQNC 965
Cdd:cd00054    2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
NOD super family cl08449
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1295-1344 4.50e-04

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


The actual alignment was detected with superfamily member pfam06816:

Pssm-ID: 462014  Cd Length: 56  Bit Score: 39.80  E-value: 4.50e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 20139103   1295 PSLAL----LVVLSPP-ALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPG 1344
Cdd:pfam06816    2 EKLAEgvlvIVVLMDPeELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 736-765 8.58e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 8.58e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 20139103  736 GPCLNGGSCNPSPGGYYCTCPPSHTGPQCQ 765
Cdd:cd00054    9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 699-726 1.25e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.25e-03
                         10        20
                 ....*....|....*....|....*...
gi 20139103  699 PCAHGGTCYPQPSGYNCTCPTGYTGPTC 726
Cdd:cd00054   10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 899-928 1.49e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.49e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 20139103  899 SLCHNGGLCVDSGPSYFCHCPPGFQGSLCQ 928
Cdd:cd00054    9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NODP super family cl06639
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1379-1420 1.93e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


The actual alignment was detected with superfamily member pfam07684:

Pssm-ID: 462229  Cd Length: 59  Bit Score: 38.41  E-value: 1.93e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 20139103   1379 AGFVVVMGVDLSRCGPDHpaSRCPWDPGLLLRFLAAMAAVGA 1420
Cdd:pfam07684    2 IGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKGG 41
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 364-390 3.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.75e-03
                         10        20
                 ....*....|....*....|....*..
gi 20139103  364 CAPGSTCIDRVGSFSCLCPPGRTGLLC 390
Cdd:cd00054   11 CQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 813-842 4.10e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.10e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 20139103  813 SPCRNRATCQDSPQGPRCLCPTGYTGGSCQ 842
Cdd:cd00054    9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 280-308 9.38e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 9.38e-03
                           10        20
                   ....*....|....*....|....*....
gi 20139103    280 CVSHQCQNGGTCQDGLDTYTCLCPETWTG 308
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1047-1084 9.57e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 9.57e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 20139103 1047 IDPCHSQ-PCFHGGTCEATAGSplgFICHCPKGFEGPTC 1084
Cdd:cd00054    2 IDECASGnPCQNGGTCVNTVGS---YRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1619-1823 4.50e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 151.26  E-value: 4.50e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1619 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrSRQTAVDART 1698
Cdd:COG0666   72 LLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL-EAGADVNAQD 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1699 EDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREG 1778
Cdd:COG0666  151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 20139103 1779 AVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAG 1823
Cdd:COG0666  231 NLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1431-1515 2.23e-29

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411988  Cd Length: 92  Bit Score: 113.26  E-value: 2.23e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1431 AVHPHAGTAPP---ANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQsaPHRRRPPLGED 1507
Cdd:cd21705    7 AVTVEEAEKDPqlvAAQLPWPLVCSSVAGVLALVLGALLGVQLIRRRQREHGALWLPPGFARHRDPN--PHRRREPVGED 84


                 ....*...
gi 20139103 1508 SIGLKALK 1515
Cdd:cd21705   85 AIGLKPLK 92
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1638-1731 5.52e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 5.52e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103   1638 LHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDartEDGTTPLMLAARLAVEDLV 1717
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 20139103   1718 EELIAAQADVGARD 1731
Cdd:pfam12796   78 KLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1619-1791 1.25e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.95  E-value: 1.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1619 LLDGGACPQaHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDART 1698
Cdd:PHA02875   21 LLDIGINPN-FEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFY 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1699 EDGTTPLMLAARLAVEDLVEELIA--AQADVGARDKWgkTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAR 1776
Cdd:PHA02875  100 KDGMTPLHLATILKKLDIMKLLIArgADPDIPNTDKF--SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMA 177

                         170
                  ....*....|....*
gi 20139103  1777 EGAVEVAQLLLGLGA 1791
Cdd:PHA02875  178 KGDIAICKMLLDSGA 192
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1634-1787 2.56e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 58.87  E-value: 2.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1634 GETPLHLAARFSRPTAARRLLEAGanP---NQPDR----AGRTPLHAAVAADAREVCQLLLRSRQTAVDARTED------ 1700
Cdd:cd22192   51 GETALHVAALYDNLEAAVVLMEAA--PelvNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSPRATGtffrpg 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1701 -------GTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARS----LLQAGADKDAQ------ 1763
Cdd:cd22192  129 pknliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQmydlILSYDKEDDLQpldlvp 208

                        170       180
                 ....*....|....*....|....
gi 20139103 1764 DNREQTPLFLAAREGAVEVAQLLL 1787
Cdd:cd22192  209 NNQGLTPFKLAAKEGNIVMFQHLV 232
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 432-473 4.22e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 4.22e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 20139103  432 DLDECLMaqqgPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCE 473
Cdd:cd00054    1 DIDECAS----GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1249-1285 5.26e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 50.60  E-value: 5.26e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 20139103   1249 PACTPAYdqyCHDHFHNGHCEKGCNTAECGWDGGDCR 1285
Cdd:pfam00066    2 PNCPYPY---CWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 551-587 1.58e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.58e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 20139103  551 DIDECRS-SPCANGGQCQDQPGAFHCKCLPGFEGPRCQ 587
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
432-473 2.29e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 2.29e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 20139103     432 DLDECLMaqqgPSPCEHGGSCLNTPGSFNCLCPPGYT-GSRCE 473
Cdd:smart00179    1 DIDECAS----GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1244-1284 3.10e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.48  E-value: 3.10e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 20139103    1244 DCETPPACTpayDQYCHDHFHNGHCEKGCNTAECGWDGGDC 1284
Cdd:smart00004    1 PQDPWSRCE---DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 314-353 5.18e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 5.18e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 20139103  314 DVDECETQGPphCRNGGTCQNSAGSFHCVCVSGWGGTSCE 353
Cdd:cd00054    1 DIDECASGNP--CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1211-1246 8.40e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.14  E-value: 8.40e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 20139103   1211 WKGCPsHSRCWLLFRDGQCHPQCDSEECLFDGYDCE 1246
Cdd:pfam00066    1 WPNCP-YPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA pfam07645
Calcium-binding EGF domain;
194-225 1.94e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.08  E-value: 1.94e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 20139103    194 DVNECFQDPGPCPKGTSCHNTLGSFQCLCPVG 225
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1207-1245 2.76e-06

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 45.78  E-value: 2.76e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 20139103    1207 VPDPWKGCPsHSRCWLLFRDGQCHPQCDSEECLFDGYDC 1245
Cdd:smart00004    1 PQDPWSRCE-DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 515-549 2.85e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.85e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 20139103  515 NECASA-PCLNHADCHDLLNGFQCICLPGFSGTRCE 549
Cdd:cd00054    3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 970-1004 3.64e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.64e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 20139103  970 DACQSQ-PCHNHGTCTPKPGGFHCACPPGFVGLRCE 1004
Cdd:cd00054    3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
551-587 3.70e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.70e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 20139103     551 DIDECRS-SPCANGGQCQDQPGAFHCKCLPGFE-GPRCQ 587
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
314-353 5.37e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 5.37e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 20139103     314 DVDECETQGPphCRNGGTCQNSAGSFHCVCVSGW-GGTSCE 353
Cdd:smart00179    1 DIDECASGNP--CQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 194-232 5.89e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 5.89e-06
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 20139103  194 DVNECfQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCE 232
Cdd:cd00054    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 769-803 1.12e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 1.12e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 20139103  769 DYCVSA-PCFNGGTCVNRPGTFSCLCAMGFQGPRCE 803
Cdd:cd00054    3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
194-232 1.41e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.41e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 20139103     194 DVNECfQDPGPCPKGTSCHNTLGSFQCLCPVG-QEGPRCE 232
Cdd:smart00179    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 590-625 2.45e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.45e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 20139103  590 VDECLS-DPCPVGASCLDLPGAFFCLCPSGFTGQLCE 625
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 475-511 5.69e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 5.69e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 20139103  475 DHNECLSQ-PCHPGSTCLDLLATFHCLCPPGLEGQLCE 511
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
515-549 5.84e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 5.84e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 20139103     515 NECASA-PCLNHADCHDLLNGFQCICLPGFS-GTRCE 549
Cdd:smart00179    3 DECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
314-346 1.25e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 1.25e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 20139103    314 DVDECETqGPPHCRNGGTCQNSAGSFHCVCVSG 346
Cdd:pfam07645    1 DVDECAT-GTHNCPANTVCVNTIGSFECRCPDG 32
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1168-1204 1.44e-04

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 40.59  E-value: 1.44e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 20139103   1168 PRCQKPGakgCEGRSGDGACDAGCSGPGGNWDGGDCS 1204
Cdd:pfam00066    2 PNCPYPY---CWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 972-1002 1.57e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 1.57e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 20139103    972 CQSQPCHNHGTCTPKPGGFHCACPPGFVGLR 1002
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
769-803 2.03e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 2.03e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 20139103     769 DYCVSA-PCFNGGTCVNRPGTFSCLCAMGFQ-GPRCE 803
Cdd:smart00179    3 DECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1165-1203 2.16e-04

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 40.39  E-value: 2.16e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 20139103    1165 SPGPRCQkpgAKGCEGRSGDGACDAGCSGPGGNWDGGDC 1203
Cdd:smart00004    3 DPWSRCE---DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 931-965 2.82e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 2.82e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 20139103  931 VNPCESR-PCQNGATCMAQPSGYLCQCAPGYDGQNC 965
Cdd:cd00054    2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
970-1004 3.39e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.39e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 20139103     970 DACQS-QPCHNHGTCTPKPGGFHCACPPGFV-GLRCE 1004
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
432-466 4.00e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.53  E-value: 4.00e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 20139103    432 DLDECLmaqQGPSPCEHGGSCLNTPGSFNCLCPPG 466
Cdd:pfam07645    1 DVDECA---TGTHNCPANTVCVNTIGSFECRCPDG 32
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1295-1344 4.50e-04

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 39.80  E-value: 4.50e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 20139103   1295 PSLAL----LVVLSPP-ALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPG 1344
Cdd:pfam06816    2 EKLAEgvlvIVVLMDPeELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 771-801 6.09e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.09e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 20139103    771 CVSAPCFNGGTCVNRPGTFSCLCAMGFQGPR 801
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 736-765 8.58e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 8.58e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 20139103  736 GPCLNGGSCNPSPGGYYCTCPPSHTGPQCQ 765
Cdd:cd00054    9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
589-625 8.89e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 8.89e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 20139103     589 EVDECLS-DPCPVGASCLDLPGAFFCLCPSGFT-GQLCE 625
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
475-511 1.09e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.09e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 20139103     475 DHNECLS-QPCHPGSTCLDLLATFHCLCPPGLE-GQLCE 511
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 699-726 1.25e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.25e-03
                         10        20
                 ....*....|....*....|....*...
gi 20139103  699 PCAHGGTCYPQPSGYNCTCPTGYTGPTC 726
Cdd:cd00054   10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 899-928 1.49e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.49e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 20139103  899 SLCHNGGLCVDSGPSYFCHCPPGFQGSLCQ 928
Cdd:cd00054    9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1379-1420 1.93e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 38.41  E-value: 1.93e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 20139103   1379 AGFVVVMGVDLSRCGPDHpaSRCPWDPGLLLRFLAAMAAVGA 1420
Cdd:pfam07684    2 IGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKGG 41
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 934-964 2.51e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.51e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 20139103    934 CESRPCQNGATCMAQPSGYLCQCAPGYDGQN 964
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 733-763 2.66e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.66e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 20139103    733 CHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQ 763
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
931-965 3.49e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 3.49e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 20139103     931 VNPCESR-PCQNGATCMAQPSGYLCQCAPGY-DGQNC 965
Cdd:smart00179    2 IDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 364-390 3.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.75e-03
                         10        20
                 ....*....|....*....|....*..
gi 20139103  364 CAPGSTCIDRVGSFSCLCPPGRTGLLC 390
Cdd:cd00054   11 CQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 813-842 4.10e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.10e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 20139103  813 SPCRNRATCQDSPQGPRCLCPTGYTGGSCQ 842
Cdd:cd00054    9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 810-838 6.78e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 6.78e-03
                           10        20
                   ....*....|....*....|....*....
gi 20139103    810 CADSPCRNRATCQDSPQGPRCLCPTGYTG 838
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 280-308 9.38e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 9.38e-03
                           10        20
                   ....*....|....*....|....*....
gi 20139103    280 CVSHQCQNGGTCQDGLDTYTCLCPETWTG 308
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1047-1084 9.57e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 9.57e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 20139103 1047 IDPCHSQ-PCFHGGTCEATAGSplgFICHCPKGFEGPTC 1084
Cdd:cd00054    2 IDECASGnPCQNGGTCVNTVGS---YRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1619-1823 4.50e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 151.26  E-value: 4.50e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1619 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrSRQTAVDART 1698
Cdd:COG0666   72 LLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL-EAGADVNAQD 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1699 EDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREG 1778
Cdd:COG0666  151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 20139103 1779 AVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAG 1823
Cdd:COG0666  231 NLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1634-1823 2.52e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 143.17  E-value: 2.52e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1634 GETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrSRQTAVDARTEDGTTPLMLAARLAV 1713
Cdd:COG0666   54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLL-EAGADVNARDKDGETPLHLAAYNGN 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1714 EDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAAR 1793
Cdd:COG0666  133 LEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212

                        170       180       190
                 ....*....|....*....|....*....|
gi 20139103 1794 ELRDQAGLAPADVAHQRNHWDLLTLLEGAG 1823
Cdd:COG0666  213 NAKDNDGKTALDLAAENGNLEIVKLLLEAG 242
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1577-1804 4.74e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 139.32  E-value: 4.74e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1577 APDLDTRGPDGVTPLMSAVCCGEVQSGTFqgawlgcpepwepLLDGGACPQAHTVGtGETPLHLAARFSRPTAARRLLEA 1656
Cdd:COG0666   77 GADINAKDDGGNTLLHAAARNGDLEIVKL-------------LLEAGADVNARDKD-GETPLHLAAYNGNLEIVKLLLEA 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1657 GANPNQPDRAGRTPLHAAVAADAREVCQLLLrSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKT 1736
Cdd:COG0666  143 GADVNAQDNDGNTPLHLAAANGNLEIVKLLL-EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKT 221

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20139103 1737 ALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPA 1804
Cdd:COG0666  222 ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1431-1515 2.23e-29

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411988  Cd Length: 92  Bit Score: 113.26  E-value: 2.23e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1431 AVHPHAGTAPP---ANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQsaPHRRRPPLGED 1507
Cdd:cd21705    7 AVTVEEAEKDPqlvAAQLPWPLVCSSVAGVLALVLGALLGVQLIRRRQREHGALWLPPGFARHRDPN--PHRRREPVGED 84


                 ....*...
gi 20139103 1508 SIGLKALK 1515
Cdd:cd21705   85 AIGLKPLK 92
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1638-1823 5.72e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.90  E-value: 5.72e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1638 LHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLV 1717
Cdd:COG0666   24 LLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1718 EELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRD 1797
Cdd:COG0666  104 KLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARD 183

                        170       180
                 ....*....|....*....|....*.
gi 20139103 1798 QAGLAPADVAHQRNHWDLLTLLEGAG 1823
Cdd:COG0666  184 NDGETPLHLAAENGHLEIVKLLLEAG 209
JMTM_Notch cd21701
juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus ...
 1431-1514 1.05e-19

juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus notch homolog (Notch) proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. They operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch proteins, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411984  Cd Length: 85  Bit Score: 85.12  E-value: 1.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1431 AVHPHAGTAPPAnQLPWPVLCSPVAGVILLALGALLVLQLIRRRRReHGALWLPPGFTRRPRTQsaPHRRRPPLGEDSIG 1510
Cdd:cd21701    6 SVRSEPGPATKT-TPPAQLSPLVVAAVCVLLVLVVLGVLVARKRRR-HGTLWFPEGFPRTRASR--RSRRRDPVGQDSVG 81


                 ....
gi 20139103 1511 LKAL 1514
Cdd:cd21701   82 LKNL 85
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1653-1823 9.88e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 85.78  E-value: 9.88e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1653 LLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDK 1732
Cdd:COG0666    6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1733 WGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNH 1812
Cdd:COG0666   86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                        170
                 ....*....|.
gi 20139103 1813 WDLLTLLEGAG 1823
Cdd:COG0666  166 LEIVKLLLEAG 176
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1638-1731 5.52e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 5.52e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103   1638 LHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDartEDGTTPLMLAARLAVEDLV 1717
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 20139103   1718 EELIAAQADVGARD 1731
Cdd:pfam12796   78 KLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1619-1791 1.25e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.95  E-value: 1.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1619 LLDGGACPQaHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDART 1698
Cdd:PHA02875   21 LLDIGINPN-FEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFY 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1699 EDGTTPLMLAARLAVEDLVEELIA--AQADVGARDKWgkTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAR 1776
Cdd:PHA02875  100 KDGMTPLHLATILKKLDIMKLLIArgADPDIPNTDKF--SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMA 177

                         170
                  ....*....|....*
gi 20139103  1777 EGAVEVAQLLLGLGA 1791
Cdd:PHA02875  178 KGDIAICKMLLDSGA 192
JMTM_Notch1 cd21702
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1472-1515 3.43e-12

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins; Neurogenic locus notch homolog protein 1 (Notch1), also called translocation-associated notch protein TAN-1, functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It affects the implementation of differentiation, proliferation and apoptotic programs. It is also involved in angiogenesis, and also negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch1, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411985  Cd Length: 80  Bit Score: 63.66  E-value: 3.43e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 20139103 1472 RRRRREHGALWLPPGFTrrpRTQSAPHRRRPPLGEDSIGLKALK 1515
Cdd:cd21702   39 RKRRREHGQLWFPEGFK---VSEPSKKKRREPVGEDSVGLKPLK 79
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1619-1777 1.54e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 69.14  E-value: 1.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1619 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSrQTAVDART 1698
Cdd:PHA02878  153 LLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLEN-GASTDARD 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1699 EDGTTPLMLA-ARLAVEDLVEELIAAQADVGARDK-WGKTALHwaAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAR 1776
Cdd:PHA02878  232 KCGNTPLHISvGYCKDYDILKLLLEHGVDVNAKSYiLGLTALH--SSIKSERKLKLLLEYGADINSLNSYKLTPLSSAVK 309


                  .
gi 20139103  1777 E 1777
Cdd:PHA02878  310 Q 310
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1651-1791 2.42e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.51  E-value: 2.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1651 RRLLEAGANPNQPDRAGRTPLHAAVA---ADAREVCQLLLRSrQTAVDARTEDGTTPLMLAARLA-VEDLVEELIAAQAD 1726
Cdd:PHA03095   31 RRLLAAGADVNFRGEYGKTPLHLYLHyssEKVKDIVRLLLEA-GADVNAPERCGFTPLHLYLYNAtTLDVIKLLIKAGAD 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20139103  1727 VGARDKWGKTALHWAAAVNNARAA--RSLLQAGADKDAQDNREQTPL--FLAAREGAVEVAQLLLGLGA 1791
Cdd:PHA03095  110 VNAKDKVGRTPLHVYLSGFNINPKviRLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLIDAGA 178
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1578-1827 2.55e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.51  E-value: 2.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1578 PDLDTRGPDGVTPLMSAVCCGEVQsgtfqgawlgCPEPWEPLLDGGACPQAHTVgTGETPLHLAARFS-RPTAARRLLEA 1656
Cdd:PHA03095   38 ADVNFRGEYGKTPLHLYLHYSSEK----------VKDIVRLLLEAGADVNAPER-CGFTPLHLYLYNAtTLDVIKLLIKA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1657 GANPNQPDRAGRTPLHA-----AVAADareVCQLLLRsRQTAVDARTEDGTTPL----------------MLAA---RLA 1712
Cdd:PHA03095  107 GADVNAKDKVGRTPLHVylsgfNINPK---VIRLLLR-KGADVNALDLYGMTPLavllksrnanvellrlLIDAgadVYA 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1713 VED------------------LVEELIAAQADVGARDKWGKTALHWAAAVNNARAA--RSLLQAGADKDAQDNREQTPLF 1772
Cdd:PHA03095  183 VDDrfrsllhhhlqsfkprarIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSlvLPLLIAGISINARNRYGQTPLH 262

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 20139103  1773 LAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLL-TLLEGAGPPEA 1827
Cdd:PHA03095  263 YAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVrAALAKNPSAET 318
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1705-1791 4.67e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 4.67e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103   1705 LMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWaAAVNNARAARSLLQAGADKDAQDNReQTPLFLAAREGAVEVAQ 1784
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHL-AAKNGHLEIVKLLLEHADVNLKDNG-RTALHYAARSGHLEIVK 78


                   ....*..
gi 20139103   1785 LLLGLGA 1791
Cdd:pfam12796   79 LLLEKGA 85
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1671-1764 1.41e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 59.74  E-value: 1.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103   1671 LHAAVAADAREVCQLLLRSRqTAVDARTEDGTTPLMLAARLAVEDLVEELIAaQADVGARDKwGKTALHWAAAVNNARAA 1750
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 20139103   1751 RSLLQAGADKDAQD 1764
Cdd:pfam12796   78 KLLLEKGADINVKD 91
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1619-1696 8.56e-10

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 63.76  E-value: 8.56e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20139103  1619 LLDGGACPQAHTVgTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDA 1696
Cdd:PTZ00322  101 LLTGGADPNCRDY-DGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177
JMTM_Notch2 cd21703
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1473-1514 8.94e-10

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins; Neurogenic locus notch homolog protein 2 (Notch2) functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch2 is involved in bone remodeling and homeostasis. In collaboration with RELA/p65, it enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Notch2 positively regulates self-renewal of liver cancer cells. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch2, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411986  Cd Length: 82  Bit Score: 57.08  E-value: 8.94e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 20139103 1473 RRRREHGALWLPPGFTrrPRTQSAPHRRRPPLGEDSIGLKAL 1514
Cdd:cd21703   43 KRKRKHGPLWFPEGFI--LNKENSNRKRREPVGQDAVGMKNL 82
Ank_4 pfam13637
Ankyrin repeats (many copies);
1636-1687 2.31e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.97  E-value: 2.31e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 20139103   1636 TPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLL 1687
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1685-1823 3.94e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.97  E-value: 3.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1685 LLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQD 1764
Cdd:COG0666    5 LLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKD 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 20139103 1765 NREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAG 1823
Cdd:COG0666   85 DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAG 143
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1619-1824 7.25e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 60.45  E-value: 7.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1619 LLDGGACPQAHTVGTgETPLHLAARF-----SRPTAARRLLEAGANPNQPDRAGRTPLHAAVAadaREVCQL----LLRS 1689
Cdd:PHA03100   54 LLDNGADINSSTKNN-STPLHYLSNIkynltDVKEIVKLLLEYGANVNAPDNNGITPLLYAIS---KKSNSYsiveYLLD 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1690 RQTAVDARTEDGTTPLMLAARLAVEDL--VEELIAAQADVGARDKwgktalhwaaavnnaraARSLLQAGADKDAQDNRE 1767
Cdd:PHA03100  130 NGANVNIKNSDGENLLHLYLESNKIDLkiLKLLIDKGVDINAKNR-----------------VNYLLSYGVPINIKDVYG 192

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 20139103  1768 QTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAGP 1824
Cdd:PHA03100  193 FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1653-1798 1.43e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 60.08  E-value: 1.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1653 LLEAGANPNQPDRAGRTPLHAAVAADA--REVCQLLlrSRQTAVDARTEDGTTPLMLAARLAVE-DLVEELIAAQADVGA 1729
Cdd:PHA02876  259 LYDAGFSVNSIDDCKNTPLHHASQAPSlsRLVPKLL--ERGADVNAKNIKGETPLYLMAKNGYDtENIRTLIMLGADVNA 336

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1730 RDKWGKTALHWAAAVNNARAAR-SLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQ 1798
Cdd:PHA02876  337 ADRLYITPLHQASTLDRNKDIViTLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQ 406
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1634-1787 2.56e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 58.87  E-value: 2.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1634 GETPLHLAARFSRPTAARRLLEAGanP---NQPDR----AGRTPLHAAVAADAREVCQLLLRSRQTAVDARTED------ 1700
Cdd:cd22192   51 GETALHVAALYDNLEAAVVLMEAA--PelvNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSPRATGtffrpg 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1701 -------GTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARS----LLQAGADKDAQ------ 1763
Cdd:cd22192  129 pknliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQmydlILSYDKEDDLQpldlvp 208

                        170       180
                 ....*....|....*....|....
gi 20139103 1764 DNREQTPLFLAAREGAVEVAQLLL 1787
Cdd:cd22192  209 NNQGLTPFKLAAKEGNIVMFQHLV 232
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 432-473 4.22e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 4.22e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 20139103  432 DLDECLMaqqgPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCE 473
Cdd:cd00054    1 DIDECAS----GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1249-1285 5.26e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 50.60  E-value: 5.26e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 20139103   1249 PACTPAYdqyCHDHFHNGHCEKGCNTAECGWDGGDCR 1285
Cdd:pfam00066    2 PNCPYPY---CWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 551-587 1.58e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.58e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 20139103  551 DIDECRS-SPCANGGQCQDQPGAFHCKCLPGFEGPRCQ 587
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
432-473 2.29e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 2.29e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 20139103     432 DLDECLMaqqgPSPCEHGGSCLNTPGSFNCLCPPGYT-GSRCE 473
Cdd:smart00179    1 DIDECAS----GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1244-1284 3.10e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.48  E-value: 3.10e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 20139103    1244 DCETPPACTpayDQYCHDHFHNGHCEKGCNTAECGWDGGDC 1284
Cdd:smart00004    1 PQDPWSRCE---DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 314-353 5.18e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 5.18e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 20139103  314 DVDECETQGPphCRNGGTCQNSAGSFHCVCVSGWGGTSCE 353
Cdd:cd00054    1 DIDECASGNP--CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1211-1246 8.40e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.14  E-value: 8.40e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 20139103   1211 WKGCPsHSRCWLLFRDGQCHPQCDSEECLFDGYDCE 1246
Cdd:pfam00066    1 WPNCP-YPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
JMTM_Notch3 cd21704
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1471-1512 9.52e-07

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins; Neurogenic locus notch homolog protein 3 (Notch3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch3, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411987  Cd Length: 90  Bit Score: 48.59  E-value: 9.52e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 20139103 1471 IRRRRREHGALWLPPGFTRrpRTQSAPHRRRPPLGEDSIGLK 1512
Cdd:cd21704   47 VARRKREHSTLWFPEGFFL--KKESSNKNRREPVGQDALGMK 86
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1753-1851 9.55e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.13  E-value: 9.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1753 LLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLL----------EGA 1822
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLsrhsqchfelGAN 180

                          90       100
                  ....*....|....*....|....*....
gi 20139103  1823 GPPEARHKATPGREAGPFPRARTVSVSVP 1851
Cdd:PTZ00322  181 AKPDSFTGKPPSLEDSPISSHHPDFSAVP 209
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1617-1828 1.31e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.53  E-value: 1.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1617 EPLLDGGACPQAHTVGTgETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLlrsrqtaVDA 1696
Cdd:PHA02876  162 EMLLEGGADVNAKDIYC-ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAI-------IDN 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1697 RTEDGTTPLMLAARLAVEDLVEELIAAQA--DVGARDKWGKTALHWAAAVNN-ARAARSLLQAGADKDAQDNREQTPLFL 1773
Cdd:PHA02876  234 RSNINKNDLSLLKAIRNEDLETSLLLYDAgfSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPLYL 313

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 20139103  1774 AAREG-AVEVAQLLLGLGAARELRDQAGLAPADVAH--QRNHWDLLTLLEGAGPPEAR 1828
Cdd:PHA02876  314 MAKNGyDTENIRTLIMLGADVNAADRLYITPLHQAStlDRNKDIVITLLELGANVNAR 371
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1636-1774 1.52e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.53  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1636 TPLHLAARfsRPTAAR---RLLEAGANPNQPDRAGRTPLH--AAVAADAREVCQLLlrSRQTAVDARTEDGTTPLMLAAR 1710
Cdd:PHA02876  275 TPLHHASQ--APSLSRlvpKLLERGADVNAKNIKGETPLYlmAKNGYDTENIRTLI--MLGADVNAADRLYITPLHQAST 350

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20139103  1711 L-AVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLA 1774
Cdd:PHA02876  351 LdRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFA 415
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1619-1797 1.70e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.14  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1619 LLDGGACPQAHTVgTGETPLHLAARFSRPTA-ARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDAR 1697
Cdd:PHA02876  293 LLERGADVNAKNI-KGETPLYLMAKNGYDTEnIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLLELGANVNAR 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1698 TEDGTTPLMLAA--------------RLAVEDL--------------------VEELIAAQADVGARDKWGKTALHWAAA 1743
Cdd:PHA02876  372 DYCDKTPIHYAAvrnnvviintlldyGADIEALsqkigtalhfalcgtnpymsVKTLIDRGANVNSKNKDLSTPLHYACK 451

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 20139103  1744 VNNARAARS-LLQAGADKDAQDNREQTPLFLAAreGAVEVAQLLLGLGAarELRD 1797
Cdd:PHA02876  452 KNCKLDVIEmLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGA--ELRD 502
Ank_5 pfam13857
Ankyrin repeats (many copies);
1619-1674 1.92e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.57  E-value: 1.92e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 20139103   1619 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAA 1674
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
EGF_CA pfam07645
Calcium-binding EGF domain;
194-225 1.94e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.08  E-value: 1.94e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 20139103    194 DVNECFQDPGPCPKGTSCHNTLGSFQCLCPVG 225
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1207-1245 2.76e-06

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 45.78  E-value: 2.76e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 20139103    1207 VPDPWKGCPsHSRCWLLFRDGQCHPQCDSEECLFDGYDC 1245
Cdd:smart00004    1 PQDPWSRCE-DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 515-549 2.85e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.85e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 20139103  515 NECASA-PCLNHADCHDLLNGFQCICLPGFSGTRCE 549
Cdd:cd00054    3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 970-1004 3.64e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.64e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 20139103  970 DACQSQ-PCHNHGTCTPKPGGFHCACPPGFVGLRCE 1004
Cdd:cd00054    3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
551-587 3.70e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.70e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 20139103     551 DIDECRS-SPCANGGQCQDQPGAFHCKCLPGFE-GPRCQ 587
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
314-353 5.37e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 5.37e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 20139103     314 DVDECETQGPphCRNGGTCQNSAGSFHCVCVSGW-GGTSCE 353
Cdd:smart00179    1 DIDECASGNP--CQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 194-232 5.89e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 5.89e-06
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 20139103  194 DVNECfQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCE 232
Cdd:cd00054    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1579-1664 6.39e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 46.26  E-value: 6.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103   1579 DLDTRGPDGVTPLMSAVCCGEVQSGTFqgawlgcpepwepLLDggaCPQAHTVGTGETPLHLAARFSRPTAARRLLEAGA 1658
Cdd:pfam12796   22 DANLQDKNGRTALHLAAKNGHLEIVKL-------------LLE---HADVNLKDNGRTALHYAARSGHLEIVKLLLEKGA 85


                   ....*.
gi 20139103   1659 NPNQPD 1664
Cdd:pfam12796   86 DINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1634-1693 1.03e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 50.05  E-value: 1.03e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1634 GETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTA 1693
Cdd:PHA03100  192 GFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSI 251
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1753-1819 1.11e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.49  E-value: 1.11e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20139103   1753 LLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARElrDQAGLAPADVAHQRNHWDLLTLL 1819
Cdd:pfam12796   16 LLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLEIVKLL 80
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 769-803 1.12e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 1.12e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 20139103  769 DYCVSA-PCFNGGTCVNRPGTFSCLCAMGFQGPRCE 803
Cdd:cd00054    3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
194-232 1.41e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.41e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 20139103     194 DVNECfQDPGPCPKGTSCHNTLGSFQCLCPVG-QEGPRCE 232
Cdd:smart00179    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1639-1720 1.58e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.90  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1639 HLAARfSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLR--SRQTAVDartEDGTTPLMLAARLAVEDL 1716
Cdd:PTZ00322   88 QLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEfgADPTLLD---KDGKTPLELAEENGFREV 163


                  ....
gi 20139103  1717 VEEL 1720
Cdd:PTZ00322  164 VQLL 167
Ank_5 pfam13857
Ankyrin repeats (many copies);
1653-1708 2.03e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.87  E-value: 2.03e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 20139103   1653 LLEAG-ANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQtAVDARTEDGTTPLMLA 1708
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGV-DLNLKDEEGLTALDLA 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 590-625 2.45e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.45e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 20139103  590 VDECLS-DPCPVGASCLDLPGAFFCLCPSGFTGQLCE 625
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA02946 PHA02946
ankyin-like protein; Provisional
 1617-1787 4.20e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 48.51  E-value: 4.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1617 EPLLDGGACPQaHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAR--EVCQLLLRSRQTAV 1694
Cdd:PHA02946   56 EELLHRGYSPN-ETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEviERINLLVQYGAKIN 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1695 DARTEDGTTPLmLAARLAVEDLVEELIAAQADVGARDKWGKTAL--HWAAAVNNARAARSLLQAGADKDAQDNREQTPLF 1772
Cdd:PHA02946  135 NSVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDHDGNTPLH 213

                         170
                  ....*....|....*..
gi 20139103  1773 LAAREGA--VEVAQLLL 1787
Cdd:PHA02946  214 IVCSKTVknVDIINLLL 230
Ank_5 pfam13857
Ankyrin repeats (many copies);
1686-1739 5.21e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 5.21e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 20139103   1686 LLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALH 1739
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 475-511 5.69e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 5.69e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 20139103  475 DHNECLSQ-PCHPGSTCLDLLATFHCLCPPGLEGQLCE 511
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
515-549 5.84e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 5.84e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 20139103     515 NECASA-PCLNHADCHDLLNGFQCICLPGFS-GTRCE 549
Cdd:smart00179    3 DECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1636-1803 1.13e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 46.88  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1636 TPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrsrqtavdartEDGTTPLMLAARLAVED 1715
Cdd:PHA02874   37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLI-----------DNGVDTSILPIPCIEKD 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1716 LVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAAREL 1795
Cdd:PHA02874  106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANV 185


                  ....*...
gi 20139103  1796 RDQAGLAP 1803
Cdd:PHA02874  186 KDNNGESP 193
EGF_CA pfam07645
Calcium-binding EGF domain;
314-346 1.25e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 1.25e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 20139103    314 DVDECETqGPPHCRNGGTCQNSAGSFHCVCVSG 346
Cdd:pfam07645    1 DVDECAT-GTHNCPANTVCVNTIGSFECRCPDG 32
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1168-1204 1.44e-04

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 40.59  E-value: 1.44e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 20139103   1168 PRCQKPGakgCEGRSGDGACDAGCSGPGGNWDGGDCS 1204
Cdd:pfam00066    2 PNCPYPY---CWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 972-1002 1.57e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 1.57e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 20139103    972 CQSQPCHNHGTCTPKPGGFHCACPPGFVGLR 1002
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1634-1665 1.58e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.74  E-value: 1.58e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 20139103   1634 GETPLHLAA-RFSRPTAARRLLEAGANPNQPDR 1665
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
769-803 2.03e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 2.03e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 20139103     769 DYCVSA-PCFNGGTCVNRPGTFSCLCAMGFQ-GPRCE 803
Cdd:smart00179    3 DECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1165-1203 2.16e-04

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 40.39  E-value: 2.16e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 20139103    1165 SPGPRCQkpgAKGCEGRSGDGACDAGCSGPGGNWDGGDC 1203
Cdd:smart00004    3 DPWSRCE---DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 931-965 2.82e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 2.82e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 20139103  931 VNPCESR-PCQNGATCMAQPSGYLCQCAPGYDGQNC 965
Cdd:cd00054    2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1637-1819 2.88e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 45.64  E-value: 2.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1637 PLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRS-------------------------RQ 1691
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSinkcsvfytlvaikdafnnrnveifKI 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1692 TAVDARTEDGTTPLMLAARLAVEDLVEE-----LIAAQADVGARDK-WGKTALHWAAAVNNARAARSLLQAGADKDAQDN 1765
Cdd:PHA02878  120 ILTNRYKNIQTIDLVYIDKKSKDDIIEAeitklLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDK 199

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 20139103  1766 REQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQR-NHWDLLTLL 1819
Cdd:PHA02878  200 TNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLL 254
EGF_CA smart00179
Calcium-binding EGF-like domain;
970-1004 3.39e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.39e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 20139103     970 DACQS-QPCHNHGTCTPKPGGFHCACPPGFV-GLRCE 1004
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
432-466 4.00e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.53  E-value: 4.00e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 20139103    432 DLDECLmaqQGPSPCEHGGSCLNTPGSFNCLCPPG 466
Cdd:pfam07645    1 DVDECA---TGTHNCPANTVCVNTIGSFECRCPDG 32
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1295-1344 4.50e-04

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 39.80  E-value: 4.50e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 20139103   1295 PSLAL----LVVLSPP-ALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPG 1344
Cdd:pfam06816    2 EKLAEgvlvIVVLMDPeELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1720-1788 4.58e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 4.58e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20139103  1720 LIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLG 1788
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 771-801 6.09e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.09e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 20139103    771 CVSAPCFNGGTCVNRPGTFSCLCAMGFQGPR 801
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Ank_5 pfam13857
Ankyrin repeats (many copies);
1753-1807 6.27e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.64  E-value: 6.27e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 20139103   1753 LLQAG-ADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVA 1807
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 443-471 6.82e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.00  E-value: 6.82e-04
                         10        20
                 ....*....|....*....|....*....
gi 20139103  443 PSPCEHGGSCLNTPGSFNCLCPPGYTGSR 471
Cdd:cd00053    5 SNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 443-471 7.87e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 7.87e-04
                           10        20
                   ....*....|....*....|....*....
gi 20139103    443 PSPCEHGGSCLNTPGSFNCLCPPGYTGSR 471
Cdd:pfam00008    3 PNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1634-1661 8.43e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.39  E-value: 8.43e-04
                           10        20
                   ....*....|....*....|....*...
gi 20139103   1634 GETPLHLAARFSRPTAARRLLEAGANPN 1661
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 736-765 8.58e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 8.58e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 20139103  736 GPCLNGGSCNPSPGGYYCTCPPSHTGPQCQ 765
Cdd:cd00054    9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
589-625 8.89e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 8.89e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 20139103     589 EVDECLS-DPCPVGASCLDLPGAFFCLCPSGFT-GQLCE 625
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1633-1787 1.05e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 44.10  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1633 TGETPLHLAARFSRPT---AARRLLEAGANPNQPDR-----------AGRTPLHAAVAADAREVCQLLLrSRQTAVDART 1698
Cdd:cd21882   25 TGKTCLHKAALNLNDGvneAIMLLLEAAPDSGNPKElvnapctdefyQGQTALHIAIENRNLNLVRLLV-ENGADVSARA 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1699 ED-------------GTTPLMLAARLAVEDLVEELI---AAQADVGARDKWGKTALHWAAAVNNARAARS---------L 1753
Cdd:cd21882  104 TGrffrkspgnlfyfGELPLSLAACTNQEEIVRLLLengAQPAALEAQDSLGNTVLHALVLQADNTPENSafvcqmynlL 183

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 20139103 1754 LQAGADKDAQDNREQ-------TPLFLAAREGAVEVAQLLL 1787
Cdd:cd21882  184 LSYGAHLDPTQQLEEipnhqglTPLKLAAVEGKIVMFQHIL 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
475-511 1.09e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.09e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 20139103     475 DHNECLS-QPCHPGSTCLDLLATFHCLCPPGLE-GQLCE 511
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 1634-1711 1.19e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 44.02  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1634 GETPLHLAARFSRPTAARRLLEagaNPNQP------DRAGRTPLHA--AVAADAREVCQ--------LLLRSRQTAVDAR 1697
Cdd:cd22193  123 GELPLSLAACTNQPDIVQYLLE---NEHQPadieaqDSRGNTVLHAlvTVADNTKENTKfvtrmydmILIRGAKLCPTVE 199

                         90
                 ....*....|....*....
gi 20139103 1698 TE-----DGTTPLMLAARL 1711
Cdd:cd22193  200 LEeirnnDGLTPLQLAAKM 218
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 699-726 1.25e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.25e-03
                         10        20
                 ....*....|....*....|....*...
gi 20139103  699 PCAHGGTCYPQPSGYNCTCPTGYTGPTC 726
Cdd:cd00054   10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 899-928 1.49e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.49e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 20139103  899 SLCHNGGLCVDSGPSYFCHCPPGFQGSLCQ 928
Cdd:cd00054    9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1634-1776 1.74e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.03  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1634 GETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrSRQTAVDARTEDGTTPL---MLAAR 1710
Cdd:PHA02874  157 GCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLI-DHGNHIMNKCKNGFTPLhnaIIHNR 235

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20139103  1711 LAVedlveELIAAQADVGARDKWGKTALHWA-AAVNNARAARSLLQAGADKDAQDNREQTPLFLAAR 1776
Cdd:PHA02874  236 SAI-----ELLINNASINDQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKDNKGENPIDTAFK 297
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1379-1420 1.93e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 38.41  E-value: 1.93e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 20139103   1379 AGFVVVMGVDLSRCGPDHpaSRCPWDPGLLLRFLAAMAAVGA 1420
Cdd:pfam07684    2 IGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKGG 41
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 973-1002 2.14e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 2.14e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 20139103  973 QSQPCHNHGTCTPKPGGFHCACPPGFVGLR 1002
Cdd:cd00053    4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 934-964 2.51e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.51e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 20139103    934 CESRPCQNGATCMAQPSGYLCQCAPGYDGQN 964
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 733-763 2.66e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.66e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 20139103    733 CHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQ 763
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1700-1732 2.78e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 2.78e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 20139103   1700 DGTTPLMLAA-RLAVEDLVEELIAAQADVGARDK 1732
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1653-1791 2.83e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.93  E-value: 2.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1653 LLEAGANPNQPDRAGRTPLHAAvAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEEL--IAAQADVGAr 1730
Cdd:PLN03192  544 LLKAKLDPDIGDSKGRTPLHIA-ASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILyhFASISDPHA- 621

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20139103  1731 dkwGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGA 1791
Cdd:PLN03192  622 ---AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGA 679
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1635-1807 3.09e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 42.26  E-value: 3.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1635 ETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAvDARTEDGTTPLMLAARLAVE 1714
Cdd:PHA02874  125 KTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYA-NVKDNNGESPLHNAAEYGDY 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1715 DLVEELIAAQADVGARDKWGKTALHwaAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAR-EGAVEVAQLLLGLGAAR 1793
Cdd:PHA02874  204 ACIKLLIDHGNHIMNKCKNGFTPLH--NAIIHNRSAIELLINNASINDQDIDGSTPLHHAINpPCDIDIIDILLYHKADI 281

                         170
                  ....*....|....
gi 20139103  1794 ELRDQAGLAPADVA 1807
Cdd:PHA02874  282 SIKDNKGENPIDTA 295
EGF_CA smart00179
Calcium-binding EGF-like domain;
931-965 3.49e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 3.49e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 20139103     931 VNPCESR-PCQNGATCMAQPSGYLCQCAPGY-DGQNC 965
Cdd:smart00179    2 IDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
Ank_4 pfam13637
Ankyrin repeats (many copies);
1736-1787 3.54e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.25  E-value: 3.54e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 20139103   1736 TALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLL 1787
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 364-390 3.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.75e-03
                         10        20
                 ....*....|....*....|....*..
gi 20139103  364 CAPGSTCIDRVGSFSCLCPPGRTGLLC 390
Cdd:cd00054   11 CQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1633-1762 3.97e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.16  E-value: 3.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1633 TGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLrsrQTAVDARTEDGTTPLMLAARLA 1712
Cdd:PLN03192  557 KGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY---HFASISDPHAAGDLLCTAAKRN 633

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 20139103  1713 VEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDA 1762
Cdd:PLN03192  634 DLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDK 683
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 813-842 4.10e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.10e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 20139103  813 SPCRNRATCQDSPQGPRCLCPTGYTGGSCQ 842
Cdd:cd00054    9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1653-1774 4.84e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.49  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1653 LLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRqTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDK 1732
Cdd:PHA02874  110 ILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYG-ADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDN 188

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 20139103  1733 WGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLA 1774
Cdd:PHA02874  189 NGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNA 230
COG3903 COG3903
Predicted ATPase [General function prediction only];
1664-1848 4.99e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443109 [Multi-domain]  Cd Length: 933  Bit Score: 41.93  E-value: 4.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1664 DRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAA 1743
Cdd:COG3903    3 AAAAAAAAAAAAALALLALAAAAAAAAAAAALAAALEALRAALALLLLLLAALALALAALALLLAAAALLLRLLLLLLAA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1744 VNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAG 1823
Cdd:COG3903   83 RLLARLAAAAAAALARAAAAALALLLRLRLAARRLLLARALAAAALAAAAAAAAAAAAAPAPPPPAPPPPAPLAALARRA 162

                        170       180
                 ....*....|....*....|....*
gi 20139103 1824 PPEARhkatpgREAGPFPRARTVSV 1848
Cdd:COG3903  163 AALAA------AARALLSAARLVTL 181
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 810-838 6.78e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 6.78e-03
                           10        20
                   ....*....|....*....|....*....
gi 20139103    810 CADSPCRNRATCQDSPQGPRCLCPTGYTG 838
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 1619-1711 7.13e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 41.28  E-value: 7.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103 1619 LLDGGACPQAHTVGT-------------GETPLHLAARFSRPTAARRLLEAGANP-NQPDRAGRTPLHAAV-AADAREVC 1683
Cdd:cd22194  160 LIAKGADVNAHAKGVffnpkykhegfyfGETPLALAACTNQPEIVQLLMEKESTDiTSQDSRGNTVLHALVtVAEDSKTQ 239

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 20139103 1684 ---------QLLLRSRQTAVDA-RTEDGTTPLMLAARL 1711
Cdd:cd22194  240 ndfvkrmydMILLKSENKNLETiRNNEGLTPLQLAAKM 277
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1705-1800 9.30e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.78  E-value: 9.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20139103  1705 LMLAARLAVEDlVEELIAAQADVGARDKWGKTALHWAAAVNNARAA---RSLLQAGADKDAQDNREQTPLFLAAREGAVE 1781
Cdd:PHA03095   19 LLNASNVTVEE-VRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKdivRLLLEAGADVNAPERCGFTPLHLYLYNATTL 97

                          90       100
                  ....*....|....*....|
gi 20139103  1782 -VAQLLLGLGAARELRDQAG 1800
Cdd:PHA03095   98 dVIKLLIKAGADVNAKDKVG 117
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 280-308 9.38e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 9.38e-03
                           10        20
                   ....*....|....*....|....*....
gi 20139103    280 CVSHQCQNGGTCQDGLDTYTCLCPETWTG 308
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1047-1084 9.57e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 9.57e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 20139103 1047 IDPCHSQ-PCFHGGTCEATAGSplgFICHCPKGFEGPTC 1084
Cdd:cd00054    2 IDECASGnPCQNGGTCVNTVGS---YRCSCPPGYTGRNC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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