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Conserved domains on  [gi|74731618|sp|Q96EW2|]
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RecName: Full=HSPB1-associated protein 1; AltName: Full=27 kDa heat shock protein-associated protein 1; AltName: Full=Protein associated with small stress protein 1

Protein Classification

cupin-like domain-containing protein( domain architecture ID 10613792)

cupin-like domain-containing protein adopts a beta-barrel fold, similar to Homo sapiens lysine-specific demethylase 8, tRNA wybutosine-synthesizing protein 5, HSPB1-associated protein 1, and hypoxia-inducible factor 1-alpha inhibitor

CATH:  2.60.120.10
Gene Ontology:  GO:0046872
PubMed:  19478949|14697267
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cupin_8 pfam13621
Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.
 37-272 2.34e-39

Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.


:

Pssm-ID: 463936  Cd Length: 251  Bit Score: 142.89  E-value: 2.34e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74731618    37 IMSLQQPAIFCNMVFDWPA-RHWN----AKYLSQVL-------------HGKQIRFRMGMKSMStvpqfettCNYVEATL 98
Cdd:pfam13621   8 YVAKNKPVVIRGAVKDWPAvQKWTdsslLDYLKDKYgdvevtvevtpdgRADRLFYNDDFTFVN--------PKEERMPF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74731618    99 EEFLtwncdqSSISGPFRDYDHSkfWAYADY----KYFVSLFEDktdlfQDVKWSDFGFpGRNGQESTLWIGSLGAHTPC 174
Cdd:pfam13621  80 GEFL------DRLEAGEDTDTAP--YAYLQSdnlrSEFPELLED-----NDLPFATEAF-GGEPDAVNLWMGNGRSVTSL 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74731618   175 HLDSYGcNLVFQVQGRKRWHLFPPEDTPFLYPTRI-PYEESSVFSKINVVNPDLKRFPQFRKAQR-HAVTLSPGQVLFVP 252
Cdd:pfam13621 146 HYDHYE-NLYCVVRGRKRFTLFPPSDVPNLYPGPLePTPEGQVFSLVDPLAPDFERFPRFRDAARpLVVTLNPGDVLYLP 224

                         250       260
                  ....*....|....*....|
gi 74731618   253 RHWWHYVESIDPVTVSINSW 272
Cdd:pfam13621 225 ALWWHHVESLDPFNIAVNYW 244
 
Name Accession Description Interval E-value
Cupin_8 pfam13621
Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.
 37-272 2.34e-39

Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.


Pssm-ID: 463936  Cd Length: 251  Bit Score: 142.89  E-value: 2.34e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74731618    37 IMSLQQPAIFCNMVFDWPA-RHWN----AKYLSQVL-------------HGKQIRFRMGMKSMStvpqfettCNYVEATL 98
Cdd:pfam13621   8 YVAKNKPVVIRGAVKDWPAvQKWTdsslLDYLKDKYgdvevtvevtpdgRADRLFYNDDFTFVN--------PKEERMPF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74731618    99 EEFLtwncdqSSISGPFRDYDHSkfWAYADY----KYFVSLFEDktdlfQDVKWSDFGFpGRNGQESTLWIGSLGAHTPC 174
Cdd:pfam13621  80 GEFL------DRLEAGEDTDTAP--YAYLQSdnlrSEFPELLED-----NDLPFATEAF-GGEPDAVNLWMGNGRSVTSL 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74731618   175 HLDSYGcNLVFQVQGRKRWHLFPPEDTPFLYPTRI-PYEESSVFSKINVVNPDLKRFPQFRKAQR-HAVTLSPGQVLFVP 252
Cdd:pfam13621 146 HYDHYE-NLYCVVRGRKRFTLFPPSDVPNLYPGPLePTPEGQVFSLVDPLAPDFERFPRFRDAARpLVVTLNPGDVLYLP 224

                         250       260
                  ....*....|....*....|
gi 74731618   253 RHWWHYVESIDPVTVSINSW 272
Cdd:pfam13621 225 ALWWHHVESLDPFNIAVNYW 244
RoxA COG2850
Ribosomal protein L16 Arg81 hydroxylase, contains JmjC domain [Translation, ribosomal ...
 166-285 1.37e-11

Ribosomal protein L16 Arg81 hydroxylase, contains JmjC domain [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442098  Cd Length: 274  Bit Score: 64.84  E-value: 1.37e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74731618 166 GSLGAHtpchLDSYGcnlVF--QVQGRKRWHLFPPEDTPflyPTRIPyeessvfskinvvNPDLKRFPQFRKAQRhaVTL 243
Cdd:COG2850 117 GGVGPH----FDSYD---VFllQGEGRRRWRIGDQPDDD---PELVP-------------DLPLRILADFEPEID--WVL 171

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 74731618 244 SPGQVLFVPRHWWHYVESIDP-VTVSI----NSWIELEEDHLARVEE 285
Cdd:COG2850 172 EPGDMLYLPPGFAHDGVALEEcMTYSIgfraPSWAELLSELADYLAD 218
cupin_OxDC-like cd20306
Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and ...
 219-262 2.26e-04

Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and eukaryotic cupin domains of proteins homologous to oxalate decarboxylase (OxDC; EC 4.1.1.2) such as MSMEG_2254, a putative OxDC from Mycobacterium smegmatis. OxDC is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues.


Pssm-ID: 380440 [Multi-domain]  Cd Length: 151  Bit Score: 41.42  E-value: 2.26e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 74731618 219 KINVVNPDlkrfpqfrkAQRHAVTLSPGQVLFVPRHWWHYVESI 262
Cdd:cd20306  67 RVSILDPT---------GSLDTFTVKPGQVVFIPQGWLHWIENV 101
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 138-189 2.59e-04

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 38.77  E-value: 2.59e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 74731618    138 DKTDLFQDVkwsDFGFPGRNGQeSTLWIGSLGAHTPCHLDSYG-CNLVFQVQG 189
Cdd:smart00558  10 FKLNLLSDL---PEDIPGPDVG-PYLYMGMAGSTTPWHIDDYDlVNYLHQGAG 58
 
Name Accession Description Interval E-value
Cupin_8 pfam13621
Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.
 37-272 2.34e-39

Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.


Pssm-ID: 463936  Cd Length: 251  Bit Score: 142.89  E-value: 2.34e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74731618    37 IMSLQQPAIFCNMVFDWPA-RHWN----AKYLSQVL-------------HGKQIRFRMGMKSMStvpqfettCNYVEATL 98
Cdd:pfam13621   8 YVAKNKPVVIRGAVKDWPAvQKWTdsslLDYLKDKYgdvevtvevtpdgRADRLFYNDDFTFVN--------PKEERMPF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74731618    99 EEFLtwncdqSSISGPFRDYDHSkfWAYADY----KYFVSLFEDktdlfQDVKWSDFGFpGRNGQESTLWIGSLGAHTPC 174
Cdd:pfam13621  80 GEFL------DRLEAGEDTDTAP--YAYLQSdnlrSEFPELLED-----NDLPFATEAF-GGEPDAVNLWMGNGRSVTSL 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74731618   175 HLDSYGcNLVFQVQGRKRWHLFPPEDTPFLYPTRI-PYEESSVFSKINVVNPDLKRFPQFRKAQR-HAVTLSPGQVLFVP 252
Cdd:pfam13621 146 HYDHYE-NLYCVVRGRKRFTLFPPSDVPNLYPGPLePTPEGQVFSLVDPLAPDFERFPRFRDAARpLVVTLNPGDVLYLP 224

                         250       260
                  ....*....|....*....|
gi 74731618   253 RHWWHYVESIDPVTVSINSW 272
Cdd:pfam13621 225 ALWWHHVESLDPFNIAVNYW 244
RoxA COG2850
Ribosomal protein L16 Arg81 hydroxylase, contains JmjC domain [Translation, ribosomal ...
 166-285 1.37e-11

Ribosomal protein L16 Arg81 hydroxylase, contains JmjC domain [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442098  Cd Length: 274  Bit Score: 64.84  E-value: 1.37e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74731618 166 GSLGAHtpchLDSYGcnlVF--QVQGRKRWHLFPPEDTPflyPTRIPyeessvfskinvvNPDLKRFPQFRKAQRhaVTL 243
Cdd:COG2850 117 GGVGPH----FDSYD---VFllQGEGRRRWRIGDQPDDD---PELVP-------------DLPLRILADFEPEID--WVL 171

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 74731618 244 SPGQVLFVPRHWWHYVESIDP-VTVSI----NSWIELEEDHLARVEE 285
Cdd:COG2850 172 EPGDMLYLPPGFAHDGVALEEcMTYSIgfraPSWAELLSELADYLAD 218
JmjC_2 pfam08007
JmjC domain; This entry includes proteins with a JmjC domain that belong to the cupin ...
 166-269 3.28e-09

JmjC domain; This entry includes proteins with a JmjC domain that belong to the cupin superfamily, including Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, Ribosomal oxygenase 1/2, and 50S ribosomal protein L16 3-hydroxylase from Escherichia coli. Proteins are bifunctional, acting as histone lysine demethylases and ribosomal histidine hydroxylases.


Pssm-ID: 462340  Cd Length: 116  Bit Score: 54.57  E-value: 3.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74731618   166 GSLGAHtpchLDSYGcnlVF--QVQGRKRWHLFPPedtpflyptriPYEESSVFSkinvvNPDLKRFPQFRKAqrHAVTL 243
Cdd:pfam08007  26 GGVGPH----YDDYD---VFllQGEGRKRWRVGAP-----------KVPDLEFYS-----DPPLRILDDFEPV--HDFVL 80

                          90       100
                  ....*....|....*....|....*..
gi 74731618   244 SPGQVLFVPRHWWHYVESIDP-VTVSI 269
Cdd:pfam08007  81 EPGDMLYLPRGFIHQGVALDEsLHYSV 107
cupin_OxDC-like cd20306
Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and ...
 219-262 2.26e-04

Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and eukaryotic cupin domains of proteins homologous to oxalate decarboxylase (OxDC; EC 4.1.1.2) such as MSMEG_2254, a putative OxDC from Mycobacterium smegmatis. OxDC is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues.


Pssm-ID: 380440 [Multi-domain]  Cd Length: 151  Bit Score: 41.42  E-value: 2.26e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 74731618 219 KINVVNPDlkrfpqfrkAQRHAVTLSPGQVLFVPRHWWHYVESI 262
Cdd:cd20306  67 RVSILDPT---------GSLDTFTVKPGQVVFIPQGWLHWIENV 101
JmjC smart00558
A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of ...
 138-189 2.59e-04

A domain family that is part of the cupin metalloenzyme superfamily; Probable enzymes, but of unknown functions, that regulate chromatin reorganisation processes (Clissold and Ponting, in press).


Pssm-ID: 214721  Cd Length: 58  Bit Score: 38.77  E-value: 2.59e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 74731618    138 DKTDLFQDVkwsDFGFPGRNGQeSTLWIGSLGAHTPCHLDSYG-CNLVFQVQG 189
Cdd:smart00558  10 FKLNLLSDL---PEDIPGPDVG-PYLYMGMAGSTTPWHIDDYDlVNYLHQGAG 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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