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Conserved domains on  [gi|61213728|sp|Q969J5|]
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RecName: Full=Interleukin-22 receptor subunit alpha-2; Short=IL-22 receptor subunit alpha-2; Short=IL-22R-alpha-2; Short=IL-22RA2; AltName: Full=Cytokine receptor class-II member 10; AltName: Full=Cytokine receptor family 2 member 10; Short=CRF2-10; AltName: Full=Cytokine receptor family type 2, soluble 1; Short=CRF2-S1; AltName: Full=Interleukin-22-binding protein; Short=IL-22BP; Short=IL22BP; AltName: Full=ZcytoR16; Flags: Precursor

Protein Classification

Tissue_fac and Interfer-bind domain-containing protein( domain architecture ID 10471435)

Tissue_fac and Interfer-bind domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 7-146 1.93e-38

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


:

Pssm-ID: 460067  Cd Length: 107  Bit Score: 130.20  E-value: 1.93e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61213728     7 FLGFLISFFLTGVAGTQSTHESLKPQRVQFQSRNFHNILQWQPGRALTGNsSVYFVQYKImfscsmksshqkpsgcwqhi 86
Cdd:pfam01108   1 LLTLLLGLLLLALASAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPD-VVYTVQYKI-------------------- 59

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 61213728    87 scnfpgcrtlakYGQRQWKNKEDCWGTQELSCDLTSETSDIQEPYYGRVRAASAGSYSEW 146
Cdd:pfam01108  60 ------------YGSGDWKNVPNCTNITRTECDLTDETSDLTETYYARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 158-263 1.33e-27

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


:

Pssm-ID: 462746  Cd Length: 103  Bit Score: 102.04  E-value: 1.33e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61213728   158 TKIDPPVMNITQVNGSLLVILHAPNLpyryQKEKNVSIEDYYE-LLYRVFIINNSLEKEQKVYEGAHRAVEIEALTPHSS 236
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVTVKDPET----REGKNLSLRDLYGsLQYRVSYWKNSSNGEKKNTTSTNSFVVLSDLEPGTT 76

                          90       100
                  ....*....|....*....|....*..
gi 61213728   237 YCVVAEIYQPMLDRRSQRSEERCVEIP 263
Cdd:pfam09294  77 YCVSVQAFSPLDNKSSQRSPPQCIRTT 103
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 7-146 1.93e-38

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 130.20  E-value: 1.93e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61213728     7 FLGFLISFFLTGVAGTQSTHESLKPQRVQFQSRNFHNILQWQPGRALTGNsSVYFVQYKImfscsmksshqkpsgcwqhi 86
Cdd:pfam01108   1 LLTLLLGLLLLALASAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPD-VVYTVQYKI-------------------- 59

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 61213728    87 scnfpgcrtlakYGQRQWKNKEDCWGTQELSCDLTSETSDIQEPYYGRVRAASAGSYSEW 146
Cdd:pfam01108  60 ------------YGSGDWKNVPNCTNITRTECDLTDETSDLTETYYARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 158-263 1.33e-27

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 102.04  E-value: 1.33e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61213728   158 TKIDPPVMNITQVNGSLLVILHAPNLpyryQKEKNVSIEDYYE-LLYRVFIINNSLEKEQKVYEGAHRAVEIEALTPHSS 236
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVTVKDPET----REGKNLSLRDLYGsLQYRVSYWKNSSNGEKKNTTSTNSFVVLSDLEPGTT 76

                          90       100
                  ....*....|....*....|....*..
gi 61213728   237 YCVVAEIYQPMLDRRSQRSEERCVEIP 263
Cdd:pfam09294  77 YCVSVQAFSPLDNKSSQRSPPQCIRTT 103
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 7-146 1.93e-38

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 130.20  E-value: 1.93e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61213728     7 FLGFLISFFLTGVAGTQSTHESLKPQRVQFQSRNFHNILQWQPGRALTGNsSVYFVQYKImfscsmksshqkpsgcwqhi 86
Cdd:pfam01108   1 LLTLLLGLLLLALASAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPD-VVYTVQYKI-------------------- 59

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 61213728    87 scnfpgcrtlakYGQRQWKNKEDCWGTQELSCDLTSETSDIQEPYYGRVRAASAGSYSEW 146
Cdd:pfam01108  60 ------------YGSGDWKNVPNCTNITRTECDLTDETSDLTETYYARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 158-263 1.33e-27

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 102.04  E-value: 1.33e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61213728   158 TKIDPPVMNITQVNGSLLVILHAPNLpyryQKEKNVSIEDYYE-LLYRVFIINNSLEKEQKVYEGAHRAVEIEALTPHSS 236
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVTVKDPET----REGKNLSLRDLYGsLQYRVSYWKNSSNGEKKNTTSTNSFVVLSDLEPGTT 76

                          90       100
                  ....*....|....*....|....*..
gi 61213728   237 YCVVAEIYQPMLDRRSQRSEERCVEIP 263
Cdd:pfam09294  77 YCVSVQAFSPLDNKSSQRSPPQCIRTT 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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