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Conserved domains on  [gi|215274261|sp|Q8NEP3|]
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RecName: Full=Dynein axonemal assembly factor 1; AltName: Full=Leucine-rich repeat-containing protein 50

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-296 1.61e-43

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 156.48  E-value: 1.61e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 112 LYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENL 191
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 192 SCLPVLNTLQM------------------------------AHNHLETVEDIQHLQeclRLCVLDLSHNKLSD-PEILSI 240
Cdd:cd21340   87 ENLTNLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLAPLR---NLEQLDASNNQISDlEELLDL 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215274261 241 LESMPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWAR 296
Cdd:cd21340  164 LSSWPSLRELDLTGNPVCKK-PKYRDKIILASKSLEVLDGKEITDTERQFLKRLKA 218
PHA03169 super family cl27451
hypothetical protein; Provisional
 296-492 1.87e-04

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PHA03169:

Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 44.58  E-value: 1.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 296 RGGYAAEKEERQQWESRERK-KITDSIEALAMIKQRAEERKRQRESQERGEMTS--------SDDGENVPASAEGKEEPP 366
Cdd:PHA03169  26 HGGTREQAGRRRGTAARAAKpAPPAPTTSGPQVRAVAEQGHRQTESDTETAEESrhgekeerGQGGPSGSGSESVGSPTP 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 367 GDRETRQkmELFVKESFEAKDELCPEKPSGEEPPvEAKREDGGP----EPEGTLPAETLLLSSPVEVKGEDGDGEPEGtl 442
Cdd:PHA03169 106 SPSGSAE--ELASGLSPENTSGSSPESPASHSPP-PSPPSHPGPhepaPPESHNPSPNQQPSSFLQPSHEDSPEEPEP-- 180

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 215274261 443 PAEAPPPPPPVEVKGEDGDQEPEGTLPAETlllsppvkvKGEDGDREPEG 492
Cdd:PHA03169 181 PTSEPEPDSPGPPQSETPTSSPPPQSPPDE---------PGEPQSPTPQQ 221
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-296 1.61e-43

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 156.48  E-value: 1.61e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 112 LYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENL 191
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 192 SCLPVLNTLQM------------------------------AHNHLETVEDIQHLQeclRLCVLDLSHNKLSD-PEILSI 240
Cdd:cd21340   87 ENLTNLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLAPLR---NLEQLDASNNQISDlEELLDL 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215274261 241 LESMPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWAR 296
Cdd:cd21340  164 LSSWPSLRELDLTGNPVCKK-PKYRDKIILASKSLEVLDGKEITDTERQFLKRLKA 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
111-279 1.58e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 1.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 111 TLYLHFKGFDRI-ENLEEYTGLRCLWLQSNGIQKI-ENLEAQTELRCLFLQMNLLRKI-ENLEPLQKLDALNLSNNYIKT 187
Cdd:COG4886  117 SLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 188 I-ENLSCLPVLNTLQMAHNHLETVEDIqhLQECLRLCVLDLSHNKLSDpeiLSILESMPDLRVLNLMGNPvIRQIPNyrr 266
Cdd:COG4886  197 LpEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNNQLTD---LPELGNLTNLEELDLSNNQ-LTDLPP--- 267

                        170
                 ....*....|...
gi 215274261 267 tvTVRLKHLTYLD 279
Cdd:COG4886  268 --LANLTNLKTLD 278
LRR_9 pfam14580
Leucine-rich repeat;
166-302 2.44e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 62.86  E-value: 2.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261  166 IENL-EPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNH-LETVEDIQHLQECLRlcVLDLSHNKLSDPEILSILES 243
Cdd:pfam14580  34 IENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRiCRIGEGLGEALPNLT--ELILTNNNLQELGDLDPLAS 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 215274261  244 MPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAE 302
Cdd:pfam14580 112 LKKLTFLSLLRNPVTNK-PHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQ 169
PHA03169 PHA03169
hypothetical protein; Provisional
 296-492 1.87e-04

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 44.58  E-value: 1.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 296 RGGYAAEKEERQQWESRERK-KITDSIEALAMIKQRAEERKRQRESQERGEMTS--------SDDGENVPASAEGKEEPP 366
Cdd:PHA03169  26 HGGTREQAGRRRGTAARAAKpAPPAPTTSGPQVRAVAEQGHRQTESDTETAEESrhgekeerGQGGPSGSGSESVGSPTP 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 367 GDRETRQkmELFVKESFEAKDELCPEKPSGEEPPvEAKREDGGP----EPEGTLPAETLLLSSPVEVKGEDGDGEPEGtl 442
Cdd:PHA03169 106 SPSGSAE--ELASGLSPENTSGSSPESPASHSPP-PSPPSHPGPhepaPPESHNPSPNQQPSSFLQPSHEDSPEEPEP-- 180

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 215274261 443 PAEAPPPPPPVEVKGEDGDQEPEGTLPAETlllsppvkvKGEDGDREPEG 492
Cdd:PHA03169 181 PTSEPEPDSPGPPQSETPTSSPPPQSPPDE---------PGEPQSPTPQQ 221
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 173-274 9.21e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 9.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 173 QKLDALNLSNNYIKTI--ENLSCLPVLNTLQMAHNHLeTVEDIQHLQECLRLCVLDLSHNKLSDpEILSILESMPDLRVL 250
Cdd:PLN00113 475 KRLENLDLSRNQFSGAvpRKLGSLSELMQLKLSENKL-SGEIPDELSSCKKLVSLDLSHNQLSG-QIPASFSEMPVLSQL 552

                         90       100
                 ....*....|....*....|....*...
gi 215274261 251 NLMGNPVIRQIP----NYRRTVTVRLKH 274
Cdd:PLN00113 553 DLSQNQLSGEIPknlgNVESLVQVNISH 580
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-296 1.61e-43

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 156.48  E-value: 1.61e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 112 LYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENL 191
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 192 SCLPVLNTLQM------------------------------AHNHLETVEDIQHLQeclRLCVLDLSHNKLSD-PEILSI 240
Cdd:cd21340   87 ENLTNLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLAPLR---NLEQLDASNNQISDlEELLDL 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 215274261 241 LESMPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWAR 296
Cdd:cd21340  164 LSSWPSLRELDLTGNPVCKK-PKYRDKIILASKSLEVLDGKEITDTERQFLKRLKA 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
111-279 1.58e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 1.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 111 TLYLHFKGFDRI-ENLEEYTGLRCLWLQSNGIQKI-ENLEAQTELRCLFLQMNLLRKI-ENLEPLQKLDALNLSNNYIKT 187
Cdd:COG4886  117 SLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 188 I-ENLSCLPVLNTLQMAHNHLETVEDIqhLQECLRLCVLDLSHNKLSDpeiLSILESMPDLRVLNLMGNPvIRQIPNyrr 266
Cdd:COG4886  197 LpEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNNQLTD---LPELGNLTNLEELDLSNNQ-LTDLPP--- 267

                        170
                 ....*....|...
gi 215274261 267 tvTVRLKHLTYLD 279
Cdd:COG4886  268 --LANLTNLKTLD 278
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
89-279 9.56e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 9.56e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261  89 TKSSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKI-ENLEAQTELRCLFLQMNLLRKI- 166
Cdd:COG4886   73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLp 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 167 ENLEPLQKLDALNLSNNYIKTI-ENLSCLPVLNTLQMAHNHLETVEDiqHLQECLRLCVLDLSHNKLSDpeILSILESMP 245
Cdd:COG4886  153 EPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEELDLSGNQLTD--LPEPLANLT 228

                        170       180       190
                 ....*....|....*....|....*....|....
gi 215274261 246 DLRVLNLMGNPvIRQIPNYRrtvtvRLKHLTYLD 279
Cdd:COG4886  229 NLETLDLSNNQ-LTDLPELG-----NLTNLEELD 256
LRR_9 pfam14580
Leucine-rich repeat;
166-302 2.44e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 62.86  E-value: 2.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261  166 IENL-EPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNH-LETVEDIQHLQECLRlcVLDLSHNKLSDPEILSILES 243
Cdd:pfam14580  34 IENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRiCRIGEGLGEALPNLT--ELILTNNNLQELGDLDPLAS 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 215274261  244 MPDLRVLNLMGNPVIRQiPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAE 302
Cdd:pfam14580 112 LKKLTFLSLLRNPVTNK-PHYRLYVIYKVPQLRLLDFRKVKQKERQAAEKMFRSKQGKQ 169
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
111-263 6.19e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 6.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 111 TLYLHFKGFDRI-ENLEEYTGLRCLWLQSNGIQKI-ENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTI 188
Cdd:COG4886  186 ELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDL 265

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215274261 189 ENLSCLPVLNTLQMAHNHLETVEdIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDLRVLNLMGNPVIRQIPN 263
Cdd:COG4886  266 PPLANLTNLKTLDLSNNQLTDLK-LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-279 1.37e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 1.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261  91 SSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLE 170
Cdd:COG4886   14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 171 PLQKLDALNLSNNyiktiENLSCLPVLNTLQMAHNHLETV-EDIQHLQEcLRlcVLDLSHNKLSDpeILSILESMPDLRV 249
Cdd:COG4886   94 DLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTN-LK--ELDLSNNQLTD--LPEPLGNLTNLKS 163

                        170       180       190
                 ....*....|....*....|....*....|
gi 215274261 250 LNLMGNPvIRQIPNyrrtVTVRLKHLTYLD 279
Cdd:COG4886  164 LDLSNNQ-LTDLPE----ELGNLTNLKELD 188
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 221-265 5.80e-07

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 46.47  E-value: 5.80e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 215274261  221 RLCVLDLSHNKLSDpeiLSILESMPDLRVLNLMGNPVIRQIPNYR 265
Cdd:pfam12799   2 NLEVLDLSNNQITD---IPPLAKLPNLETLDLSGNNKITDLSDLA 43
LRR_8 pfam13855
Leucine rich repeat;
151-207 1.20e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.20e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 215274261  151 TELRCLFLQMNLLRKI--ENLEPLQKLDALNLSNNYIKTIEN--LSCLPVLNTLQMAHNHL 207
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 122-255 6.08e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.40  E-value: 6.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 122 IENLEEYTGLRCLWLQSNGIQK------IENLEAQTELRCLFLQMN------LLRKIENLEPLQKLDALNLSNNYIKT-- 187
Cdd:COG5238  229 AEALKGNKSLTTLDLSNNQIGDegvialAEALKNNTTVETLYLSGNqigaegAIALAKALQGNTTLTSLDLSVNRIGDeg 308

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 215274261 188 ----IENLSCLPVLNTLQMAHNHLETVEDI---QHLQECLRLCVLDLSHNKLSDP---EILSILESMPDLRVLNLMGN 255
Cdd:COG5238  309 aialAEGLQGNKTLHTLNLAYNGIGAQGAIalaKALQENTTLHSLDLSDNQIGDEgaiALAKYLEGNTTLRELNLGKN 386
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 151-192 1.99e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 42.23  E-value: 1.99e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 215274261  151 TELRCLFLQMNLLRKIENLEPLQKLDALNLS-NNYIKTIENLS 192
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLA 43
LRR_8 pfam13855
Leucine rich repeat;
195-257 2.33e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.33e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 215274261  195 PVLNTLQMAHNHLETVED--IQHLQeclRLCVLDLSHNKLS--DPEILSileSMPDLRVLNLMGNPV 257
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLS---NLKVLDLSNNLLTtlSPGAFS---GLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 173-218 6.27e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.69  E-value: 6.27e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 215274261  173 QKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLetVEDIQHLQE 218
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSDLAN 44
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
102-279 6.61e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.08  E-value: 6.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 102 LYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLS 181
Cdd:COG4886    6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 182 NNYIKTIENLSCLPVLNtlqmahnhLETVEDIQHLQEclrLCVLDLSHNKLSDpeILSILESMPDLRVLNLMGNPvIRQI 261
Cdd:COG4886   86 LLGLTDLGDLTNLTELD--------LSGNEELSNLTN---LESLDLSGNQLTD--LPEELANLTNLKELDLSNNQ-LTDL 151

                        170
                 ....*....|....*...
gi 215274261 262 PnyrrTVTVRLKHLTYLD 279
Cdd:COG4886  152 P----EPLGNLTNLKSLD 165
PHA03169 PHA03169
hypothetical protein; Provisional
 296-492 1.87e-04

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 44.58  E-value: 1.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 296 RGGYAAEKEERQQWESRERK-KITDSIEALAMIKQRAEERKRQRESQERGEMTS--------SDDGENVPASAEGKEEPP 366
Cdd:PHA03169  26 HGGTREQAGRRRGTAARAAKpAPPAPTTSGPQVRAVAEQGHRQTESDTETAEESrhgekeerGQGGPSGSGSESVGSPTP 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 367 GDRETRQkmELFVKESFEAKDELCPEKPSGEEPPvEAKREDGGP----EPEGTLPAETLLLSSPVEVKGEDGDGEPEGtl 442
Cdd:PHA03169 106 SPSGSAE--ELASGLSPENTSGSSPESPASHSPP-PSPPSHPGPhepaPPESHNPSPNQQPSSFLQPSHEDSPEEPEP-- 180

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 215274261 443 PAEAPPPPPPVEVKGEDGDQEPEGTLPAETlllsppvkvKGEDGDREPEG 492
Cdd:PHA03169 181 PTSEPEPDSPGPPQSETPTSSPPPQSPPDE---------PGEPQSPTPQQ 221
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 122-257 2.16e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 2.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 122 IENLEEYTGLRCLWLQSNGIQK-----IENLEAQTELRCLFLQMNLLRK------IENLEPLQ-KLDALNLSNNyikTIE 189
Cdd:cd00116   74 LQGLTKGCGLQELDLSDNALGPdgcgvLESLLRSSSLQELKLNNNGLGDrglrllAKGLKDLPpALEKLVLGRN---RLE 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 190 NLSC------LPV---LNTLQMAHNHLeTVEDIQHLQECLR----LCVLDLSHNKLSDPEILSI---LESMPDLRVLNLM 253
Cdd:cd00116  151 GASCealakaLRAnrdLKELNLANNGI-GDAGIRALAEGLKancnLEVLDLNNNGLTDEGASALaetLASLKSLEVLNLG 229


                 ....
gi 215274261 254 GNPV 257
Cdd:cd00116  230 DNNL 233
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 129-174 2.32e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 2.32e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 215274261  129 TGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNllRKIENLEPLQK 174
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN--NKITDLSDLAN 44
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 173-274 9.21e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 9.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 173 QKLDALNLSNNYIKTI--ENLSCLPVLNTLQMAHNHLeTVEDIQHLQECLRLCVLDLSHNKLSDpEILSILESMPDLRVL 250
Cdd:PLN00113 475 KRLENLDLSRNQFSGAvpRKLGSLSELMQLKLSENKL-SGEIPDELSSCKKLVSLDLSHNQLSG-QIPASFSEMPVLSQL 552

                         90       100
                 ....*....|....*....|....*...
gi 215274261 251 NLMGNPVIRQIP----NYRRTVTVRLKH 274
Cdd:PLN00113 553 DLSQNQLSGEIPknlgNVESLVQVNISH 580
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 122-275 9.28e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.47  E-value: 9.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 122 IENLEEYTGLRCLWLQSNGIQK------IENLEAQTELRCLFLQMNLLRK------IENLEPLQKLDALNLSNNYIKT-- 187
Cdd:COG5238  257 AEALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIGAqg 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 188 ----IENLSCLPVLNTLQMAHNHL--ETVEDI-QHLQECLRLCVLDLSHNKLSDPEILSILESM--PDLRVLNLMGNPVI 258
Cdd:COG5238  337 aialAKALQENTTLHSLDLSDNQIgdEGAIALaKYLEGNTTLRELNLGKNNIGKQGAEALIDALqtNRLHTLILDGNLIG 416

                        170
                 ....*....|....*..
gi 215274261 259 RQIpnyRRTVTVRLKHL 275
Cdd:COG5238  417 AEA---QQRLEQLLERI 430
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 173-279 1.05e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.08  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 173 QKLDALNLSNNYIKTI------ENLSCLPVLNTLQMAHNHL---ETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILES 243
Cdd:COG5238  180 NSVETVYLGCNQIGDEgieelaEALTQNTTVTTLWLKRNPIgdeGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEA 259

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 215274261 244 MPD---LRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLD 279
Cdd:COG5238  260 LKNnttVETLYLSGNQIGAEGAIALAKALQGNTTLTSLD 298
PTZ00121 PTZ00121
MAEBL; Provisional
 287-388 1.17e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261  287 DRACAEAWARGGYAAEK-EERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQER-GEMTSSDDGENVPASAEGKEE 364
Cdd:PTZ00121 1687 EKKAAEALKKEAEEAKKaEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKkAEEAKKDEEEKKKIAHLKKEE 1766

                          90       100
                  ....*....|....*....|....
gi 215274261  365 PPGDRETRQKMELFVKESFEAKDE 388
Cdd:PTZ00121 1767 EKKAEEIRKEKEAVIEEELDEEDE 1790
PHA03169 PHA03169
hypothetical protein; Provisional
 339-492 3.50e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 40.34  E-value: 3.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215274261 339 ESQERGEMTSSDDGENVPASAEGKEEPPGDRETRQKMELFVKESFEAKDELCPEKPSGEEPPVEAKREDGGPEPEGTLPA 418
Cdd:PHA03169 114 LASGLSPENTSGSSPESPASHSPPPSPPSHPGPHEPAPPESHNPSPNQQPSSFLQPSHEDSPEEPEPPTSEPEPDSPGPP 193

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 215274261 419 ET-LLLSSPVEVKGEDGDGEPEGTLPAEAPPPPPPVEVKGEDGDQEPEGTLPAETLLLSPPVKVKGEDGDREPEG 492
Cdd:PHA03169 194 QSeTPTSSPPPQSPPDEPGEPQSPTPQQAPSPNTQQAVEHEDEPTEPEREGPPFPGHRSHSYTVVGWKPSTRPGG 268
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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