|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
79-502 |
0e+00 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 744.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 79 AVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANR 158
Cdd:cd17382 1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGGKVIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 159 VFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLA 238
Cdd:cd17382 81 VFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 239 GVLVQYIGWASVFYIYGMFGIIWYMFWLLQayecpavhptisneertyietsigeganlaslskfntpwrrfftSLPVYA 318
Cdd:cd17382 161 GILVQYVGWSSPFYVYGVFGIIWYMFWMLV--------------------------------------------SMPVYA 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 319 IIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNCGGFG 398
Cdd:cd17382 197 IIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGGFG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 399 MEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTRE 478
Cdd:cd17382 277 MEATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHKTRE 356
|
410 420
....*....|....*....|....
gi 187663976 479 EWQNVFLIAALVHYSGVIFYGVFA 502
Cdd:cd17382 357 EWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
79-502 |
4.31e-173 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 495.99 E-value: 4.31e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 79 AVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGK-------PEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFIS 151
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNtstdkdtLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 152 NKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGA 231
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 232 VVAMPLAGVLVQYIGWASVFYIYGMFGIIWYMFWllqayecpavhptisneertyietsigeganlaslskfntpwrrFF 311
Cdd:cd17318 161 VIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLW--------------------------------------------FF 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 312 TSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKI 391
Cdd:cd17318 197 LVLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRKL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 392 MNCGGFGMEATLLLVVGF-SHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGA 470
Cdd:cd17318 277 FTSIGFLGPGVFLIALGYlGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGA 356
|
410 420 430
....*....|....*....|....*....|...
gi 187663976 471 MTKHK-TREEWQNVFLIAALVHYSGVIFYGVFA 502
Cdd:cd17318 357 IVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
78-502 |
2.48e-125 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 374.50 E-value: 2.48e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 78 IAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGK-----PEIQTAQ----------FNWDPETVGLIHGSFFWGYIV 142
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNssnacPEHSSSPsvehnetgkkYDWDAETQGWILGSFFYGYII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 143 TQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATT 222
Cdd:cd17381 81 TQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 223 SFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIWYMFWllqayecpavhptisneertyietsigeganlaslsk 302
Cdd:cd17381 161 SYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLW------------------------------------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 303 fntpwrrFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKI 382
Cdd:cd17381 204 -------IWLVMPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQN 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 383 LTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGV-AISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSG 461
Cdd:cd17381 277 FSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSlAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPG 356
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 187663976 462 MVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYGVFA 502
Cdd:cd17381 357 MVGPVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
84-502 |
1.73e-99 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 306.40 E-value: 1.73e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 84 LGFCISFGIRCNLGVAIVEMvnnstvyvdgkpeiqTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAA 163
Cdd:cd17380 6 LATCICYADRVNMPIAIVPM---------------AKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 164 IFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQ 243
Cdd:cd17380 71 VALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 244 YIGWASVFYIYGMFGIIWYMFWllqayecpavhptisneertyietsigeganlaslskfntpwrrFFTSLPVYAIIVAN 323
Cdd:cd17380 151 YYGWPSVFYFFGLLGLLWALVW--------------------------------------------LIYLPPVWAIIVAH 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 324 FCRSWTFYLLLISQPAYFEEVFGfAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKIlTTTAVRKIMNCGGFGMEATL 403
Cdd:cd17380 187 FCMNWGFYILLSWLPTYFHEVLV-PLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGW-TVTSVRKLMQSIGFLGPALF 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 404 LLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGA-MTKHKTreeWQN 482
Cdd:cd17380 265 LLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYiLEATGS---WSL 341
|
410 420
....*....|....*....|
gi 187663976 483 VFLIAALVHYSGVIFYGVFA 502
Cdd:cd17380 342 VFVLAAVVNLVGAVVFLLFG 361
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
75-513 |
1.69e-96 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 302.43 E-value: 1.69e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 75 RYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKP-------EIQTAQFNWDPETVGLIHGSFFWGYIVTQIPG 147
Cdd:TIGR00894 17 RLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLsaeneldNIKNPNFKWSGALQGLILSSHFYGQIIIQIPV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 148 GFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGS 227
Cdd:TIGR00894 97 GYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 228 YAGAVVAMPLAGVLVQY-IGWASVFYIYGMFGIIWYMFWLLQAYECPAVHPTISNEERTYIETSIgEGANlaSLSKFNTP 306
Cdd:TIGR00894 177 QLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSL-QGQK--GSTRQSLP 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 307 WRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTT 386
Cdd:TIGR00894 254 IKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTLSLT 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 387 AVRKIMN-CGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCP 465
Cdd:TIGR00894 334 AARKIFNgIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGGLIAS 413
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 187663976 466 LIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQDWADPE 513
Cdd:TIGR00894 414 TLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEE 461
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
75-471 |
5.35e-47 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 168.52 E-value: 5.35e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 75 RYIIAVMSGLGFCISFGIRCNLGVAIVEMVnnstvyvdgkpeiqtAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKF 154
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIM---------------KDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRF 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 155 AANRVFGAAIFLTSTLNMFIpSAARVHYGCVMCvRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVA 234
Cdd:cd17319 66 GARKVLAVSMLLWSLFTALT-GFATSLTSLYVL-RFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 235 MPLAGVLVQYIGWASVFYIYGMFGIIWYMFWLLqayecpaVHPTisneertyietsigeganlaslskfntpwrrfftsl 314
Cdd:cd17319 144 PPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWF-------YLRQ------------------------------------ 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 315 pVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKiltttavRKIMNC 394
Cdd:cd17319 181 -VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA-------RRLVII 252
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 187663976 395 GGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPR-YASILMGISNGVGTLSGMVCPLIVGAM 471
Cdd:cd17319 253 IGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGGNLGGFVAPLLIGYL 330
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
73-502 |
9.30e-47 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 168.12 E-value: 9.30e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 73 PKRYIIAVMSGLGFCISFGIRCNLGVAIVEMvnnstvyvdgkpeiqTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISN 152
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPL---------------QADLGLSAAQLGLLASAFFLGYALGQIPAGLLAD 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 153 KFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMcvRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAV 232
Cdd:COG2271 71 RFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLL--RFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 233 VAMPLAGVLVQYIGWASVFYIYGMFGIIWymfwllqayecpAVhptisneertyietsigeganlaslskfntpwrrfft 312
Cdd:COG2271 149 LAPPLLGWLLAAFGWRAAFLILGLPGLLL------------AL------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 313 sLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRkiltttavRKIM 392
Cdd:COG2271 180 -LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR--------RKLV 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 393 NCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAP-RYASILMGISNGVGTLSGMVCPLIVGAM 471
Cdd:COG2271 251 LAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYL 330
|
410 420 430
....*....|....*....|....*....|.
gi 187663976 472 TKHKTreeWQNVFLIAALVHYSGVIFYGVFA 502
Cdd:COG2271 331 LDATG---YQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
115-463 |
1.51e-35 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 136.78 E-value: 1.51e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 115 PEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVmcVRILQGL 194
Cdd:pfam07690 20 PLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV--LRVLQGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 195 VEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIWYMFWLLqayecpa 274
Cdd:pfam07690 98 GAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 275 vhptisNEERTYIETSIGEGANLASLSKfntPWRRFFTSLPVYAIIVAnFCRSWTFYLLLISQPAYfEEVFGFAISKVGL 354
Cdd:pfam07690 171 ------PRPPPESKRPKPAEEARLSLIV---AWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLY-QEVLGLSALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 355 LSAVPHMVMTIVVPIGGQLADYLRSRKILtttavrkIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGF 434
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRRRL-------LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPAL 312
|
330 340 350
....*....|....*....|....*....|
gi 187663976 435 NVNHLDIAP-RYASILMGISNGVGTLSGMV 463
Cdd:pfam07690 313 NALVSDLAPkEERGTASGLYNTAGSLGGAL 342
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
121-498 |
1.06e-31 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 126.39 E-value: 1.06e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 121 QFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAarVHYGCVMCVRILQGLVEGVTY 200
Cdd:cd06174 25 SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA--PSFWLLLLGRFLLGLGSGLID 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 201 PACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYI--GWASVFYIYGMFGIIWYMFWLLqayecpAVHPT 278
Cdd:cd06174 103 PAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLAAILLLL------VVPDP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 279 isneertyiETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAV 358
Cdd:cd06174 177 ---------PESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 359 PHMVMTIVVPIGGQLADYLRSRKILtttavrkiMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNH 438
Cdd:cd06174 248 FGLAGALGSLLLGLLSDRLIGRKPL--------LLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 439 LDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTReeWQNVFLIAALVHYSGVIFY 498
Cdd:cd06174 320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG--LTGAFLVLAVLLLLAAILL 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
119-461 |
2.80e-29 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 118.92 E-value: 2.80e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 119 TAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAArvHYGCVMCVRILQGLVEGV 198
Cdd:COG2814 37 AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP--SLWLLLAARFLQGLGAGA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 199 TYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIwymFWLLQAYECPAVHPt 278
Cdd:COG2814 115 LFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALL---ALLLLLRLLPESRP- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 279 isneertyietsigeganlASLSKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAV 358
Cdd:COG2814 191 -------------------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLAL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 359 PHMVMTIVVPIGGQLADYLRSRKILTttavrkimncGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNH 438
Cdd:COG2814 252 FGLGGVLGALLAGRLADRFGRRRLLL----------IGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALV 321
|
330 340
....*....|....*....|....
gi 187663976 439 LDIAP-RYASILMGISNGVGTLSG 461
Cdd:COG2814 322 AELAPpEARGRASGLYNSAFFLGG 345
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
73-490 |
6.55e-27 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 113.05 E-value: 6.55e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 73 PKRYIIAVMSGLGFCISFGIRCNLGVAIVEMvnnstvyvdgkpeiqTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISN 152
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPL---------------AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVD 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 153 KFAANRVFGAAIFLTSTLNMFIPSAarVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAV 232
Cdd:COG2223 66 RFGPRRVLLIGLLLLGIGLLLLALA--VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAA 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 233 VAMPLAGVLVQYIGWASVFYIYGMFGIIWYMFWLLQAYECPavhptisneertyietsigEGANLASLSKFNTpWRRFFT 312
Cdd:COG2223 144 VAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPP-------------------AGAAAAAKASLRD-QLEALR 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 313 SLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVrkim 392
Cdd:COG2223 204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFA---- 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 393 ncggfGMEATLLLVVGFSHTKGVAI-SFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAM 471
Cdd:COG2223 280 -----LMALGLLLLALALGSLWLFLvLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL 354
|
410
....*....|....*....
gi 187663976 472 tkHKTREEWQNVFLIAALV 490
Cdd:COG2223 355 --LDATGSYTAAFLVFAVL 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
129-490 |
1.06e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 106.12 E-value: 1.06e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 129 VGLIHGSFFWGYIVTQIPGGFISNKFAANR--VFGAAIFLTSTLnMFIPSAarvHYGCVMCVRILQGLVEGVTYPACHGM 206
Cdd:cd17325 33 IGLIVAAYALAQLLFSPPAGRLSDRFGRKRllLLGLLLLAVSTL-LFAFAT---SYWQLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 207 WSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIwyMFWLLQAYecpaVHPTISNEERty 286
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL--ALVLALLL----LPEPRPPPNK-- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 287 ietsigegaNLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIV 366
Cdd:cd17325 181 ---------RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 367 VPIGGQLADYLRSRKILTttavrkimncggFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHL--DIAPR 444
Cdd:cd17325 252 QPPAGKLSDRIGRKPLIL------------IGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALlaDIVPP 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 187663976 445 YA-SILMGISNGVGTLSGMVCPLIVGAMTkhkTREEWQNVFLIAALV 490
Cdd:cd17325 320 EGrGTAMGLFNTAFSLGMVLGPLLGGFLY---DAFGFATPFLAAAAL 363
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
115-502 |
1.49e-16 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 81.47 E-value: 1.49e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 115 PEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTS---TLNMFIPSaarvhYGCVMCVRIL 191
Cdd:cd17473 23 PAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGiggVAGLFLDS-----LYALLASRAL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 192 QGLVEGVTYPACHGMWSKWAPPLERSRL-----ATTSFcgsyaGAVVAMPLAGVLVQyIGWASVFYIYGMFGIIWYMFWL 266
Cdd:cd17473 98 LGIGVAGIMTLATALIGDYFEGEERAKMlglqsAAMSL-----GGVVFLLLGGALAE-IGWRAPFLVYLLALPVLILVLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 267 LqayecpavhptISNEERTYIETSIGEGANLASLskfntPWRRfftslpVYAIIVANFCRSWTFYLLLISQPAYFEEVFG 346
Cdd:cd17473 172 F-----------LPEPARKSKSAASPGAATAAAL-----PWKR------VLPIYFLAFLAMLLFYVIPIQLPFLLQERGG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 347 FAISKVGLLSAvphmVMTIVVPIGGQLADYLRSRKILTTTavrkimNCGGFGMEATLLLVVGFSHTKGVAISFLVLaVGF 426
Cdd:cd17473 230 GSAALIGLALA----IASLAGAIGALLFGRLKRRLGKRRL------LAIGFALMALGFLLLALASGLWVVLLGAIL-AGL 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 187663976 427 sGFAISGFNVNH--LDIAPRYAS-ILMGISNGVGTLSGMVCPLIVGAMTKHKTREewQNVFLIAALVHYSGVIFYGVFA 502
Cdd:cd17473 299 -GFGLLLPTLNSwaMSLVPPELRgRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGL--SGAFLILGVLALVLAIVLLLLR 374
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
120-471 |
3.58e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 74.70 E-value: 3.58e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 120 AQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFipSAARVHYGCVMCVRILQGLVEGVT 199
Cdd:TIGR00895 45 AEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLL--CALATNVTQLLILRFLAGLGLGGL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 200 YPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGII---WYMFWLLQAYECPAVH 276
Cdd:TIGR00895 123 MPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLlllLLMRFLPESIDFLVSK 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 277 PTISNEER-TYIETSIGEGAN--LASLSKFNTPWRRFF-------TSLPVYAIIVANFCRSWTFYLLLISQPaYFEEVFG 346
Cdd:TIGR00895 203 RPETVRRIvNAIAPQMQAEAQsaLPEQKSTQGTKRSVFkalfqgkTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVELG 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 347 FAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILtttavrkimncGGFGMEATLLLVVGFSHTKGVAISFLVLAVGF 426
Cdd:TIGR00895 282 FSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTA-----------LLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGF 350
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 187663976 427 sgFAISGFNVNHLDIAPRYASIL----MGISNGVGTLSGMVCPLIVGAM 471
Cdd:TIGR00895 351 --FVNGGQSGLYALMALFYPTAIratgVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
76-467 |
2.58e-13 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 71.90 E-value: 2.58e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 76 YIIAVMSGLGFCISFGIRCNLGVAivemvnnstvYVDGKPE---IQTAQFNWdpetvglIHGSFFWGYIVTQIPGGFISN 152
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNA----------AVMGMKEdlkLVGNQYNW-------GNTVFYVGYIIFELPGNLLLQ 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 153 KFAANRVFGAAIFLTSTLNMFipSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAV 232
Cdd:cd17327 67 RFPPSKWLSVFIVLWGLLTLL--TAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSI 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 233 VAMPLA-GvlVQYI-------GWASVFYIYGMFGIIW---YMFWLlqayecPAVHPTI---SNEERTYIETSIGEGANLA 298
Cdd:cd17327 145 FGGLLAyG--VFKIlgvgglaGWRWLFIIEGLITIIIglvIFFWL------PDNPSKAwflTEEEKELAVERLRANQTGK 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 299 SLSKFN-TPWRRFFTSLPVYAIIVANFCrSW-------TFYLLLISQpayfeevFGFAISKVGLLSAVPHMVMTIVVPIG 370
Cdd:cd17327 217 GDQKFKwKQIKEAFKDPRTWLLFLFFFC-SQitnngisNFLPLILKS-------LGFYSLQTNLLSVPIGALGAVSLLIA 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 371 GQLADYLRSRKILTTtavrkIMNCggFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNhlDIAPRYAS--I 448
Cdd:cd17327 289 ALLSDRFKKRGLFAI-----FACV--LALVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWIS--SNCAGYTKraT 359
|
410
....*....|....*....
gi 187663976 449 LMGISNGVGTLSGMVCPLI 467
Cdd:cd17327 360 VLAIMLIFYNVGNIVAPQI 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
115-489 |
4.78e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 70.66 E-value: 4.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 115 PEIqTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFipSAARVHYGCVMCVRILQGL 194
Cdd:cd17324 23 PDI-ARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL--AALAPSFALLLLARALAGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 195 VEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGII--WYMFWLLqayec 272
Cdd:cd17324 100 AHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLaaLLLWRLL----- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 273 pavhPTISNEERtyieTSIGEGANLASLSKFNTPWRRFFTslpvYAIIVANFCRSWTfYLllisqPAYFEEVFGFAISKV 352
Cdd:cd17324 175 ----PSLPPKKP----GSLGLLSSLLLLLRNPRLRLAYLI----TFLLFGGFFALYT-YL-----APFLTDVPGFSSSAI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 353 GLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTtavrkimncGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFsGFAIS 432
Cdd:cd17324 237 IGLLLLFGVAGVVGSPLAGRLADRGGRRALLIA---------LLLLAAALLLLTLLGPSPLLLLVGLVLWGLGF-FAAHS 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 187663976 433 GFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHktrEEWQNVFLIAAL 489
Cdd:cd17324 307 ALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDH---GGWAGVGWVGAA 360
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
117-471 |
8.73e-13 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 69.94 E-value: 8.73e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 117 IQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTST---LNMFIPSaarvhYGCVMCVRILQG 193
Cdd:cd17316 26 AAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLatlLIGLLPT-----PILLLVLRFLQG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 194 LVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLV----QYIGWASVFYIYGMFGIIwyMFWLlqa 269
Cdd:cd17316 101 IGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIpllsGDWGWRILFLIGALPALL--ALLL--- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 270 yecpavhptisneertyietsigeganlaslskfntpwRRFFTSLpvyaiIVANFCRSWTFYLLLISQPAYFEEVFGFAI 349
Cdd:cd17316 176 --------------------------------------RRRTLLL-----ILLWFFISFGYYGLTTFLPTYLQTVLGLSP 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 350 SKVGLLSAVPHMVMTIVVPIGGQLADYLRsrkiltttavRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVgFSGF 429
Cdd:cd17316 213 ATSSLYLLLISLGALVGALIAGLLSDRIG----------RKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFI-LSFF 281
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 187663976 430 AISGFNVNHLDIA----PRYASILMGISNGVGTLSGMVCPLIVGAM 471
Cdd:cd17316 282 VGGVWGALYAYLAelfpTEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
96-374 |
7.70e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 66.37 E-value: 7.70e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 96 LGVAIVEMvnNSTVYVDGKPEIQtAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVF--GAAIF-LTSTLNM 172
Cdd:COG0477 21 LGTFLEGL--DFTIVNVALPSIA-ADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLliGLLLFgLASLLCG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 173 FIPSAArvhygCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFY 252
Cdd:COG0477 98 LAPSPE-----LLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 253 IYGMFGII-WYMFWLLQAYECPAVHPTISNEERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWTFY 331
Cdd:COG0477 173 INAPLGLLaLVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLL 252
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 187663976 332 LLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLA 374
Cdd:COG0477 253 LLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
215-471 |
1.47e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 66.85 E-value: 1.47e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 215 ERSRLATTSFCGSYAGAVVAMPLAGVLVQYI------GWASVFYIYGMFGIIWYMFWLLQAYEcpavHPTISNEERTYIE 288
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKE----RPVPEEEKVSLKE 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 289 TsigeganLASLSKfNTPWRRFFtslpvyaiiVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVP 368
Cdd:COG2211 220 S-------LKALLK-NRPFLLLL---------LAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAP 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 369 IGGQLADYLRSRKILtttavrkimnCGGFGMEATLLLVVGFSHTKGVAISFLVLAVgfSGFAISGFNVNHL----DIAP- 443
Cdd:COG2211 283 LWPRLAKRFGKKKAF----------IIGLLLAALGLLLLFFLGPGNLWLLLVLAAL--AGIGLGAILVLPWamlaDVVDy 350
|
250 260 270
....*....|....*....|....*....|....*
gi 187663976 444 -------RYASILMGISNGVGTLSGMVCPLIVGAM 471
Cdd:COG2211 351 dewktgrRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
115-503 |
2.42e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 65.65 E-value: 2.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 115 PEIQTAqFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTStLNMFIPSAARvHYGCVMCVRILQGL 194
Cdd:COG0738 32 PALKDA-FGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA-LGLLLFALAP-SYPLLLLALFLLGL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 195 VEGVTYPACHGMWSKWAPPLERSRLATTSFCGSyAGAVVAMPLAGVLVQY---IGWASVFYIYGMFGIIWYMFWLLQAYe 271
Cdd:COG0738 109 GLGLLDVAANPYVAALGPETAASRLNLLHAFFS-LGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKL- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 272 cpavhPTISNEErtyiETSIGEGANLASLskfntpwrrfFTSLPVYAIIVANFC--------RSWTfylllisqPAYFEE 343
Cdd:COG0738 187 -----PEIEEEE----EEAAGSAASLKSL----------LKNPRLLLGGLAIFLyvgaegaiGDWL--------PLYLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 344 VFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVrkimncggfgMEATLLLVVGFSHTKGVAISFLVLA 423
Cdd:COG0738 240 VLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSAL----------LAAVGLLLALLAPGPWLALIGLALV 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 424 vgfsGFAISGF--NVNHL--DIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTreeWQNVFLIAALVhYSGVIFYG 499
Cdd:COG0738 310 ----GLGLSLMfpTIFSLalDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG---LRAAFLVPLVC-YLLILLLA 381
|
....
gi 187663976 500 VFAS 503
Cdd:COG0738 382 LALK 385
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
115-474 |
2.05e-10 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 62.78 E-value: 2.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 115 PEIQtAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIpsAARVHYGCVMCVRILQGL 194
Cdd:TIGR00881 19 PYLV-EEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFF--GFSTSLWVMAALWALNGI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 195 VEGVTYPACHGMWSKWAPPLERSRLATTSFCGS-YAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIWYMFWLLQAYECP 273
Cdd:TIGR00881 96 FQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHnVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 274 aVHPTISNEERTYIETSIGegaNLASLSKFNTPWRRFFTS-LPVYAIIVANFCRSWTFYLLLISQ---PAYFEEVFGFAI 349
Cdd:TIGR00881 176 -QSCGLPPAEEMPNEEPDG---DAEKKEEELTKKQIFLQYvLLNKVLWYISLGYVFVYVVRTGILdwsPLYLTQEKGFSK 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 350 SKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKiltttavRKIMNCggFGMEATLLLVVGFSHTKG---VAISFLVLAVGF 426
Cdd:TIGR00881 252 EKASWAFTLYELGGLVGTLLAGWLSDKLFNGR-------RGPLAV--FFMALIIVSLLVYWLNPAanpLMDLICLFALGF 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 187663976 427 SGFA-ISGFNVNHLDIAPRYASILM-GISNGVGTLSGMVCPLIVGAMTKH 474
Cdd:TIGR00881 323 LVYGpQMLIGVIASELAPKKAAGTAaGFVGFFAYLGGILAGLPLGYLADG 372
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
115-498 |
2.94e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.20 E-value: 2.94e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 115 PEIQtAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRV----------FGAAIFLTSTLNMFIPSaarvhygc 184
Cdd:cd17474 23 PAIA-EALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVllpglllfgiGGLLCGLSDSFALLLAG-------- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 185 vmcvRILQGLVEGVTYPACHGMWSKWAPPLERSR----LATTSFCGsyagaVVAMPLAGVLVQYIGWASVFYIYGMFGII 260
Cdd:cd17474 94 ----RALQGIGAAGLGPLALTLIGDLFEGGERAKamglYEAALGLG-----IAVGPLLGGLLAAISWRYPFFLLAALIPV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 261 --WYMFWLlqayecpaVHPTISNEERTYIETSIGeganlaslskfntpWRRFFTSLPVYAIIVANFCRSWTFYLLLISQP 338
Cdd:cd17474 165 afLAILFL--------LPEPKEKAKSSSATKLRD--------------LKKALRGRGLLTFLVSAFLYFFLYFAFLTYLP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 339 AYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGqladYLRSRKILTttavRKIMnCGGFGMEATLLLVVGFSHTKGVAIS 418
Cdd:cd17474 223 FLLELLYGISPIIIGLLFAGWSVLLALGSLFVG----RLLKKRFGA----RRIL-VIGLLLYALSLLLLGFVPSLALLLI 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 419 FLVLAVGFSGFAISGFNVNHLDIAPRYA-SILMGISNGVGTLSGMVCPLIVGAMTKHKTreeWQNVFLIAALVHYSGVIF 497
Cdd:cd17474 294 AIVLFGLGLGLNLPLLTTLVTELAPEEErGTASSLYNFVRFLGQAVGPLLFGLLLEIFG---LSAPFLVGAAIALAAAVL 370
|
.
gi 187663976 498 Y 498
Cdd:cd17474 371 L 371
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
114-497 |
6.59e-10 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 61.14 E-value: 6.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 114 KPEIQTAQFNwDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIpsAARVHYGCVMCVRILQG 193
Cdd:cd17312 26 KPPIVEEIGL-SKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFM--GFSTSLWFFAVLWGLNG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 194 LVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGM----FGIIwyMFWLLQa 269
Cdd:cd17312 103 LFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIvglvVAII--LFFFLR- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 270 yecpavhptisneertyietsigeganlaslskfNTPWRRFFTSLpvyAIIVANFCRSWTFYLLlisqPAYFEEVFGFAI 349
Cdd:cd17312 180 ----------------------------------DSPPYVWVLSL---AYAFVYIVRYACLDWG----PLYLYEVKGYSL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 350 SKVGLLSAVPHMVMTIVVPIGGQLADYL---RSRKILTTTAVRKIMNCGGFGMeatlllvvgFSHTKGVAISFLVLAVGF 426
Cdd:cd17312 219 IDAGWFSSLYEVGGIAGTILAGLLSDKLfggRRAPIAVIYMLLMTLSLALFWF---------FPHNKLLSIVLLFLIGFF 289
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 187663976 427 SGFAISGFNVNHLDIAPRY--ASILMGISNGVGTLSGMVCPLIVGAMTKHKTreeWQNVFLIAALVHYSGVIF 497
Cdd:cd17312 290 VGGPINLIGGAAAQDIGRKeaAGTATGFVGLFGYLGASLAGLPLGYIIDHYG---WSTVFYFLISAALLSVLL 359
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
115-471 |
5.01e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 58.34 E-value: 5.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 115 PEIQtAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVF--GAAIF-LTSTLNMFIPSAArvhygCVMCVRIL 191
Cdd:cd17321 20 PTIA-RDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFliGLALFgLASLLCALAPSLA-----FLIAARAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 192 QGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIwyMFWLLqaye 271
Cdd:cd17321 94 QGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV--ALLLA---- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 272 cpavhptisneertyietsigeganlaslskfntpwRRFFTSLpvyaiiVANFCRSWTFYLLLISQPAYFEEVFGFAISK 351
Cdd:cd17321 168 ------------------------------------RTFSGAV------LAAFLLGAALGGLLFLLPLYLQGVLGYSPLQ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 352 VGLLSaVPHMVMTIVV-PIGGQLADYLRSRKILTTTAVrkimnCGGFGMeATLLLVVGFSHTKGVAISFLVLAVGFsGFA 430
Cdd:cd17321 206 AGLAL-LPLALAMLVAaPLAGRLADRFGPRLVLVAGLL-----LTAVGL-LLLALLGADSSVWLLLPGLVLLGLGL-GLF 277
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 187663976 431 ISGFNVNHLDIAPR-YASILMGISNGVGTLSGMVCPLIVGAM 471
Cdd:cd17321 278 ATPLTNAALSSVPKeKAGAASGILNTARQLGGALGVALLGAL 319
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
319-490 |
2.91e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 55.89 E-value: 2.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 319 IIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLrsrkiltttAVRKIMNCGGFG 398
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF---------GRRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 399 MEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTre 478
Cdd:pfam07690 72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-- 149
|
170
....*....|..
gi 187663976 479 eWQNVFLIAALV 490
Cdd:pfam07690 150 -WRAAFLILAIL 160
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
115-431 |
4.49e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 55.27 E-value: 4.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 115 PEIQTAqFNWDPETVGLIHGSFFWGYIVTqIP-GGFISNKFAANRVFGAAIF---LTSTLNMFIPSAArvhygcVMCV-R 189
Cdd:cd17503 20 PTIMGD-LGASLDTVQWVITSYLLALAIM-IPlSGWLADRFGTRRLFLTALAlftLGSLLCGLAPNLA------SLIIfR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 190 ILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIwyMFWLlqa 269
Cdd:cd17503 92 ILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGIL--ALLL--- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 270 yecpavhptisneertyietsigegANLASLSKFNTpwrRFFTsLPVYAIIVANFCRSWTFYLLlisqPAYFEEVFGFAI 349
Cdd:cd17503 167 -------------------------APLLDLRLFKD---RNFT-LGLLLSFLLGLGLFGAMFLL----PLYLQNVLGYSA 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 350 SKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTttavrkimncGGFGMEA-TLLLVVGFSHTKGVAISFLVLAVGFSG 428
Cdd:cd17503 214 FESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLL----------AGLLLLAlGTLLLAFLTPDTSLWLIILPLFIRGLG 283
|
...
gi 187663976 429 FAI 431
Cdd:cd17503 284 MGL 286
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
115-471 |
1.53e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 53.72 E-value: 1.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 115 PEIQtAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAA---IFLTSTLNMFIPSAARVHYGCVMCvril 191
Cdd:COG2807 42 PEIR-ADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLAlllLAAGLLLRSLAPSVALLLAGTALI---- 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 192 qGLVEGVTYPACHGMWSKWAPplERSRLATTSF-CGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIWYMFWLLQAY 270
Cdd:COG2807 117 -GAGIAVGNVLLPGLIKRWFP--DRVGLMTGLYtAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 271 ECPAVHPTisneertyietsigeganlaslSKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEvFGFAIS 350
Cdd:COG2807 194 RRPAAAAA----------------------APAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 351 KVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVrkIMNCGGFgmeatLLLVVGFSHTKGVAISFLVLAVGfSGFA 430
Cdd:COG2807 251 TAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLG--LLGLAGL-----LGLLLAPGSLPWLWAVLLGLGQG-GLFP 322
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 187663976 431 ISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAM 471
Cdd:COG2807 323 LALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGAL 363
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
306-490 |
1.56e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 53.44 E-value: 1.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 306 PWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEvFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTt 385
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 386 tavrkimncGGFGMEATLLLVVGFSHTkgvaISFLVLAVGFSGFAISGFNVNHLDIAPRYAS-----ILMGISNGVGTLS 460
Cdd:COG2814 80 ---------LGLLLFALGSLLCALAPS----LWLLLAARFLQGLGAGALFPAALALIADLVPperrgRALGLLGAGLGLG 146
|
170 180 190
....*....|....*....|....*....|
gi 187663976 461 GMVCPLIVGAMTKHktrEEWQNVFLIAALV 490
Cdd:COG2814 147 PALGPLLGGLLADL---FGWRWVFLVNAVL 173
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
189-426 |
3.39e-07 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 52.68 E-value: 3.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 189 RILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYI--------GWASVFYIYGMFGII 260
Cdd:cd17367 108 RLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLgedqmaawGWRIPFLLGGVLAVV 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 261 wyMFWLLQAYEcpavhptisnEERTYIETSIGEGANLASLSKFNTPWRrffTSLPVYAIIVANfcrSWTFYLLLISQPAY 340
Cdd:cd17367 188 --VLWLRRGLE----------ETESFEAIAESNEASAGTLRELRRHPR---ELLLVVGLTAGG---TLAFYTWTTYLQKF 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 341 FEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVrkimncggFGMEATLLLVVGFSHTKGVAISFL 420
Cdd:cd17367 250 LVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGI--------GGTLATVPLLSALDHTDSPYTAFA 321
|
....*.
gi 187663976 421 VLAVGF 426
Cdd:cd17367 322 LVLVGL 327
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
189-490 |
3.56e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 52.58 E-value: 3.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 189 RILQGLVEGVTyPACHGMWSKWAPPlERSRLATTSFCGSYA-GAVVAMPLAGVLVQYIGWASVFYIYGMFGIiwymfwlL 267
Cdd:cd17504 91 RALQGIGGAVF-PLAFALVREEFPP-ERVPVAQGILSATFGiGAGIGLPLGGWIVQHLGWRWIFWTAAPVAV-------L 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 268 QAYECPAVHPtisneertyietsigeganlaslskfntpwrRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEE---- 343
Cdd:cd17504 162 LAALVPLIDL-------------------------------RLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptpt 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 344 VFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTtavrkimncgGFGMEATLLLVVGFSHTKGVAISF--LV 421
Cdd:cd17504 211 GFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLI----------GLVISAVGLLLLALLHSSLWALVValLL 280
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 187663976 422 LAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGA-MTKHKTREE---------WQNVFLIAALV 490
Cdd:cd17504 281 IGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAiLTTYTVSITsggvptegaYVLAFLIGAAL 359
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
125-471 |
8.00e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 51.43 E-value: 8.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 125 DPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRV-------FGAAIFLT---STLNMFipsaarvhygcvMCVRILQGL 194
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVllvsvalFGLFTLLTafaQSVLQL------------ALLRFLTGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 195 VEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIwymfwLLqayecPA 274
Cdd:cd17365 100 GLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLI-----LL-----PL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 275 VHPTIsneertyietsigeganlaslskfnTPWRRFFTSLPVyaiivanfcrswtFYLLLISQPAYFEEVfGFAISKVGL 354
Cdd:cd17365 170 LRGTL-------------------------LLWVTFFMGLLL-------------VYLLNSWLPKLMVEA-GYSLSQALT 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 355 LSAVPHMVMTIVVPIGGQLADYLRSRKILTttavrkimncGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAI-SG 433
Cdd:cd17365 211 ITLLLNIGGVIGSLLLGWLADRFGPKRVLA----------LFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAqVG 280
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 187663976 434 FNVnhldIAPRY--ASIL---MGISNGVGTLSGMVCPLIVGAM 471
Cdd:cd17365 281 LYA----LAARFypTEVRatgVGWALGVGRLGAILGPLLGGLL 319
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
78-453 |
1.51e-06 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 50.65 E-value: 1.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 78 IAVMSGLGFCISFGircnlgvaivemvnnSTVYVDGKPEIQTaQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAAN 157
Cdd:cd17323 1 VFIISFLTFVVTFG---------------SSIYSPALPQIAE-DFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRR 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 158 RVFGAAIFLTSTLNmfIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRlATTSFC-GSYAGAVVAMP 236
Cdd:cd17323 65 PVYLVSLFIFVIFQ--IGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGK-AMGVYSlGPLLGPALGPI 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 237 LAGVLVQYIGWASVFYIYGMF-GIIWYMFWLLqayeCPAVhptisneertyietsigeganlASLSkfntpwrrFFTSLp 315
Cdd:cd17323 142 IGGFITQSLGWRWIFWFLAIIsGFCLILIFLF----LPIV----------------------LLLG--------LYVGL- 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 316 VYAIIvanfcrswtfYLLLISQPAYFEEVFGFAISKVGlLSAVPHMV-MTIVVPIGGQLADYLRSRkiltttavRKIMNC 394
Cdd:cd17323 187 VYAIL----------YLFLTAFPYVFGEVYGFSPGEVG-LMYLPIGIgALIGSIIGGRLSDYYYRR--------LKKKNG 247
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 187663976 395 GGFGMEATLLLVVgfshtkgvaISFLVLAVGFSGFAISGFNVNHLdIAPRYASILMGIS 453
Cdd:cd17323 248 GKPEPEARLPPAF---------IGAFLFPIGLFIFGWTIYPHIHW-IVPIIGSAFFGFG 296
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
308-463 |
5.89e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 48.71 E-value: 5.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 308 RRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAvpHMVMTIV-VPIGGQLADYLRSRKILTtt 386
Cdd:cd17478 189 TLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSL--FLFAGAIgTLIGGPLSDRFGRRRVII-- 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 387 avrkimncggFGMEATLLLVVGFSHTKGVAISFLVLAVGFsgFAISGFNVNHL---DIAPRYA----SILMGISNGVGTL 459
Cdd:cd17478 265 ----------ASLLLAAPFLLLFLLTPGIWSYILLVLAGF--LLFASFPVTVVlaqELLPGNVglasGLMMGLSFGLGGI 332
|
....
gi 187663976 460 SGMV 463
Cdd:cd17478 333 GAPV 336
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
108-463 |
8.87e-06 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 48.34 E-value: 8.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 108 TVYVDGKPEIQTAqFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRV--FGAAIF-LTSTLNMFIPSaarvhYGC 184
Cdd:cd17320 16 DMYLPALPAIARD-LGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVllAGLLLFiLASLLCALASS-----IEQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 185 VMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLAttsfcgSYAGAVVAM-----PLAG-VLVQYIGWASVFYIYGMFG 258
Cdd:cd17320 90 LLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIF------SLLMMILAIapalaPLLGgLLLLFFGWRAIFVFLALLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 259 II---WYMFWLlqayecpavhP-TISNEERTYIETSIGEGANLASLSkfntpwRRFFTSLPVYAIIVAnfcrswTFYLLL 334
Cdd:cd17320 164 LLlllLVLLFL----------PeTLPEEKRKPLLSSLLRAYKRVLKN------RRFLGYALALGLSFA------GLFAYL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 335 ISQPAYFEEVFGFAISKVGLLsavphMVMTIVVPIGGQLAdylrSRKILTTTAVRKIMNCG--GFGMEATLLLVVGFSHT 412
Cdd:cd17320 222 AAAPFIYIEQLGLSPAQFGLL-----FALNAIALILGSLL----NGRLVRRFGPRRLLRLGllLLLAAALVLLLAALLGG 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 187663976 413 KGVAISFLVLAVGFSGFAISGFNVNHLDIAPRY-----ASILMG-ISNGVGTLSGMV 463
Cdd:cd17320 293 LSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPhvagtASALLGfLQFLIGALAGAL 349
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
324-490 |
1.40e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 47.42 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 324 FCRSWTFYLLLISQPAY--FEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTttavrkimnCGGFGMEA 401
Cdd:cd06174 3 LGFFLTGLARGLISPLLpaLLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLL---------LGLLLFAL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 402 TLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTrEEWQ 481
Cdd:cd06174 74 GALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLG-FGWR 152
|
....*....
gi 187663976 482 NVFLIAALV 490
Cdd:cd06174 153 AVFLIAAAL 161
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
129-498 |
2.35e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.82 E-value: 2.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 129 VGLIHGSFFWGYIVTQIPGGFISNKFAANRV--FGAAIFLTSTLNMFIPSAARVhygcVMCVRILQGLVEGVTYPACHGM 206
Cdd:cd17489 33 AGLVVGLFTLAALLARPFAGRLLDRFGRKRLllIGLLIFALATLLYLLATSVAL----LLVLRLIHGIGWGAFTTAAATL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 207 WSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGII-WYMFWLlqayeCPAVHPTISNEERt 285
Cdd:cd17489 109 VADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLaLLLVFL-----VKDPPPVAAEEAE- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 286 yietsIGEGANLASLSKfntpwrrffTSLPVYAIIvanFCRSWTFYLLLISQPAYFEEVFgfaISKVGLLSAVPHMVMTI 365
Cdd:cd17489 183 -----AGTRAFRRLVEK---------KVLPPALIL---FLASIAYGAISTFLPLYAAERG---ISNAGLFFTVYAIALLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 366 VVPIGGQLADYLRSRKILTTtavrkimncgGFGMEATLLLVVGFSHTKGVA-ISFLVLAVGFsGFAISGFNVNHLDIAPR 444
Cdd:cd17489 243 SRPFSGKLSDRKGPKTVIIP----------GLLLLALGLLLLSFAGSPWMLlLAAVLYGLGF-GLLFPALQALAVDLVPP 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 187663976 445 YA-SILMGISNGVGTLSGMVCPLIVGAMTKHKtreEWQNVFLIAALVHYSGVIFY 498
Cdd:cd17489 312 HRrGAANGTFFIFFDLGIGLGGLLLGLVAELF---GYRAMFLLAAVVVLLALVLY 363
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
125-490 |
3.96e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.07 E-value: 3.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 125 DPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRV---FGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYP 201
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLlilADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 202 ACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYG---MFGIIWYMFWllqayecPAVHPT 278
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINAlsfLLSALLLLFI-------RRPPPA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 279 ISNEERTYIETSIGEGanlaslskfntpWRRFFTSLPVYAIIVANFCrSWTFYLLLISQ-PAYFEEVFGFAISKVGLLSA 357
Cdd:cd06173 185 APGESSSLLLRDLREG------------LRYLRRSPLLRLLLLALAL-FALLGGALTVLlPLLAKEVLGGGAAGYGLLLA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 358 VPhmvmtivvPIGGQLADYLRSRKILTTTAVRKIMncGGFGMEATLLLVVGFSHTKGVAISFLVLAvgfsGFAISGFNVN 437
Cdd:cd06173 252 AF--------GVGALLGALLLGRLSKRRRRGRLLL--IGALLLGLALLVLGLSPSLWLLLAALFLL----GLAGGLFNVP 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 187663976 438 -----HLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHktrEEWQNVFLIAALV 490
Cdd:cd06173 318 lntllQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADA---LGLSAVFLLAGAL 372
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
129-469 |
5.38e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.78 E-value: 5.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 129 VGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLnmFIPSAARVHYGCVMCVRILQGLVEGV----TYPACH 204
Cdd:cd17333 33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLA--LALIFATPSIYLFVVLMFLAGLGAGIldtgANTFVG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 205 GMWSKWAPplerSRLATTSFCGSyAGAVVAMPLAGVLV-QYIGWASVFYIYGMFGIIWYMFWLLqayecpavhPTISNEE 283
Cdd:cd17333 111 ALFEESSA----TRLNVLHGFFG-LGALIGPLIATSLLtSELSWSWAYLIIGLIYLLLAILILL---------TLFPELP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 284 RTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWTfylllisqPAYFEEVFGFAISKVGLLSAVPHMVM 363
Cdd:cd17333 177 SARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWV--------PSYLVEKKHVSDGLAGYLLSGFWVGI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 364 TIVVPIGGQLADYLRSRKILTTTAVrkimncggfgmEATLLLVVGFSHTKGVAISFLVLAVGFSgfaISG----FNVNHL 439
Cdd:cd17333 249 TIGRLLGGPISRRIKPHTLLVLSGS-----------GALLGLLILLLAPTLVVGLVATALLGLF---MAAlfptILSLGI 314
|
330 340 350
....*....|....*....|....*....|
gi 187663976 440 DIAPRYASILMGISNGVGTLSGMVCPLIVG 469
Cdd:cd17333 315 SNLPYAKGKGTSVLLAAGSIGGAIIPFIMG 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
122-260 |
5.39e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 45.64 E-value: 5.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 122 FNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYgcVMCVRILQGLVEGVTYP 201
Cdd:cd17325 230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWL--LLLLLALLGLGLGLVFP 307
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 202 ACHGMWSKWAPPLERSR-LATTSFCGSyAGAVVAMPLAGVLVQYIGWASVFYIYGMFGII 260
Cdd:cd17325 308 ATLALLADIVPPEGRGTaMGLFNTAFS-LGMVLGPLLGGFLYDAFGFATPFLAAAALLLL 366
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
119-497 |
1.32e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 44.60 E-value: 1.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 119 TAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVF-----GAAIFltSTLNMFIPSaarvhYGCVMCVRILQG 193
Cdd:cd17371 26 IAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLvitilLFAVF--TLLCGFAQN-----YWQLLILRALAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 194 LVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQY----IGWASVFyiygMFGII-WYMFWLLQ 268
Cdd:cd17371 99 LGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLlppeIAWRVLF----LLGALpALLVLFIR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 269 ayecPAVHPTISNEERTYIETSIGEGANLASLskFNTPWRRFFTSLPVYAIiVANFcrswTFYLLLISQPAYFEEVFGFA 348
Cdd:cd17371 175 ----RFVKEPPQWQAARAARRHFADRPSLREL--FSPPLLRTTLLASLLAT-GALG----GYYGITTWLPSYLTGERGLS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 349 ISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTttavrkIMNCGGFgmeATLLLVVGFSHTKGVaISFLVLAVGFSG 428
Cdd:cd17371 244 FEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFA------LFALGSA---ISILLYFFLPLSPTL-ILILGFPLGFFA 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187663976 429 FAISGFNVNHLDIA--PRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTreeWQNVFLIAALVHYSGVIF 497
Cdd:cd17371 314 SGPFSGMGAYLTELfpTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGS---LGTAIAVFAAVYYIAGLV 381
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
318-490 |
1.43e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 44.03 E-value: 1.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 318 AIIVANFCRSWTFYLLLISQPAYFEEvFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVrkimncgGF 397
Cdd:COG0477 18 ALALGTFLEGLDFTIVNVALPSIAAD-LGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL-------LF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 398 GMeATLLLvvGFSHTkgvaISFLVLAVGFSGFAISGFNVNHL----DIAP-RYASILMGISNGVGTLSGMVCPLIVGAMT 472
Cdd:COG0477 90 GL-ASLLC--GLAPS----PELLIAARALQGIGAGGLMPGALaliaELFPaRERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
170
....*....|....*...
gi 187663976 473 KHKTreeWQNVFLIAALV 490
Cdd:COG0477 163 AALG---WRWIFLINAPL 177
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
138-469 |
2.31e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 43.78 E-value: 2.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 138 WGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARvHYGCVMCVRILQGLVeGVTYPACHGMWSKWAPPLERS 217
Cdd:cd17341 45 LAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVS-SYWGLLVLGFLLGFA-GANFASGQPWASFWFPKEKIG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 218 RLATTSFCGSYAGAVVA---MPLA----GVLVQYIGWASVFYIYGMFGIIWYMFWLLQAYECPaVHPTISNEERTYIETS 290
Cdd:cd17341 123 GAAGGIAGAGNMGVAVSqllAPLIagaiVFDGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLP-TGKASALEFLKVQLAV 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 291 IGEGAnlaslskfntPWRRFFTSLPVYAIIVAnfcrsWTFYLllisqPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIG 370
Cdd:cd17341 202 LKNYR----------TWILSLLYGVTFGSFVG-----FSNVL-----PTYFKTRFGLPLVTAGILAALFPLAGALARPAG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 371 GQLADYLRSRKILTTtavrkimncGGFGMEATLLLVVGFSHTKGVAIS-FLVLAVGFSGFAISGFN-VNHL--DIAPRYA 446
Cdd:cd17341 262 GWLSDRFGGRRRLWW---------LFIVMTIGAALLSLSLPTSGTNLVlFLALFVALGLGAGAGNGsVFRMvpFIFRREL 332
|
330 340
....*....|....*....|...
gi 187663976 447 SILMGISNGVGTLSGMVCPLIVG 469
Cdd:cd17341 333 GAVTGLVGAIGGLGGFFLPLLFG 355
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
128-474 |
3.94e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.98 E-value: 3.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 128 TVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVriLQGLVEGVTYPACHGMW 207
Cdd:cd17329 36 IVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALV--LTGFGGGLFEPASEAMI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 208 SKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYiGWASVFYI-YGMFGIiwYMFWLLQAYecpavhPTISNEERTY 286
Cdd:cd17329 114 ADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAaAVLFLL--AALVLLFLL------PETRPKRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 287 IETSIGEGanlaslskfntpWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVpHMVMTIV 366
Cdd:cd17329 185 EKTEILRG------------YKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLAL-NALLIVL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 367 --VPIGGqLADYLRSRKILTTtavrkimncgGFGMEATLLLVVGFSHTKGVAISF-LVLAVGFSgFAISGFNVNHLDIAP 443
Cdd:cd17329 252 lqFPVAR-LVERFRLRKILMI----------GILLFAIGFAVLAFANTLAVLILAmIVLTLGEM-LVFPAVQTLVAALAP 319
|
330 340 350
....*....|....*....|....*....|....*.
gi 187663976 444 -----RYasilMGISNGVGTLSGMVCPLIVGAMTKH 474
Cdd:cd17329 320 pdkrgSY----MGFYALAWGLGRAIGPLVGGLLLDL 351
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
338-504 |
6.03e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.58 E-value: 6.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 338 PAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRK------ILTTTavrkIMNCGGFGMeatLLLVVGFSH 411
Cdd:COG2211 34 LYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwILIGA----IPLALSFVL---LFTAPDLSP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 412 TkGVAISFLVLAVGFsGFAISGFNVNHL----DIAPRYA--SILMGISNGVGTLSGMVCPLIVGAMTKH---KTREEWQN 482
Cdd:COG2211 107 T-GKLIYALVTYLLL-GLAYTLVNIPYSalgaELTPDYEerTRLSSWRFAFAGLGGLLASVLPPPLVAAfggDAALGYRL 184
|
170 180
....*....|....*....|..
gi 187663976 483 VFLIAALVhysGVIFYGVFASG 504
Cdd:COG2211 185 TALIFAVL---GLLAFLLTFFG 203
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
125-472 |
9.81e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.79 E-value: 9.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 125 DPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIpsAARVHYGCVMCVRILQGLVeGVTYPACH 204
Cdd:cd17330 32 SGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL--GLSRNLWLLFLARFLDGLT-GGNVSVAQ 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 205 GMWSKWAPPLERSR-LATTSFCGSyAGAVVAMPLAGVLVQYIGWASVFYIYGMFGII--WYMFWLLqayecpavhPTIsn 281
Cdd:cd17330 109 AYIADITDEEERAKaFGIISAAFG-LGFILGPALGGFLSTPYGYALPFLVAAALALLnlVLVLFFL---------PPL-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 282 eertyietsigeganlaslskfntpWRRFFTSLpVYAIIVANFcrSWTFYLLLISQpayfeevFGFAISKVGLLSAVPHM 361
Cdd:cd17330 177 -------------------------RRLLLVYF-LIALAFAGL--ESVFSLFLKDR-------FGFSPSQIGLLLALVGI 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 362 VMTIVvpiggQLADYLRSRKILTTtavRKIMnCGGFGMEATLLLVVGFSHTKG---VAISFLVLAVGFSGFAISGFNVNH 438
Cdd:cd17330 222 AGILA-----QLLLIPRLAKRLGE---RKLL-RLGLLLAIIGLLLLPFASSVPllvLAAAILAFGTGIVFPALSALLSKS 292
|
330 340 350
....*....|....*....|....*....|....
gi 187663976 439 LDIAPRyaSILMGISNGVGTLSGMVCPLIVGAMT 472
Cdd:cd17330 293 VPSKEQ--GKAQGIIQSLQSLARIIGPLLAGPLY 324
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
128-470 |
1.57e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.07 E-value: 1.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 128 TVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTlnMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMW 207
Cdd:cd17475 32 QVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGA--AALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 208 SKWAPPLERS-----RLATTSFcGSYAGAVVAMPLAGVLvqyiGWASVFYIYGMFGIIW-YMFWL-LQAYECPAVHPTIS 280
Cdd:cd17475 110 MRWFPPRERGlamgiRQTGVPL-GGALAAALLPPLALHY----GWRAAFVVAGLVSILAaVLFWLfYREPPAASAATESA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 281 NEERTYIetsigeganlaslskfntpwRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPH 360
Cdd:cd17475 185 STLLRSL--------------------KEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 361 ---MVMTIVVpigGQLADYLRSRKiltttaVRKIMNC-GGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNV 436
Cdd:cd17475 245 lggALGRIGL---GRVSDRVFGGR------RRPVLVItAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYL 315
|
330 340 350
....*....|....*....|....*....|....*.
gi 187663976 437 NHL-DIAP-RYASILMGISNGVGTLSGMVCPLIVGA 470
Cdd:cd17475 316 TLVaESAGpEQAGTALGLANTINFIGIAIGPPLFGL 351
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
77-471 |
3.18e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.95 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 77 IIAVMSGLGFCISFGIRCNLGVAIVEMVnnstvyvdgkpeiqtAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAA 156
Cdd:cd17355 3 VVLAVTFLILILSWGIRYYFGVFIIPII---------------AEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGP 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 157 NRV--FGAAIFLTSTLNMFIPSAARVHYGCvMCVriLQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVA 234
Cdd:cd17355 68 RRVmlLGLLLLAAGLVLLALATSLWQLYLL-WGL--LGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVF 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 235 MPLAGVLVQYIGWASVFYIYGMFGII-----WYMFWLLQAYECPAVHPTISNEERTYIETSIGEGANLASLSKFNtpwrr 309
Cdd:cd17355 145 LPLGAALIEAFGWRTALLVLALLALLvlvpvLLLLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAF----- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 310 FFTSLPVYAIIVanfcrswtfyllliSQPAYFEEvFGFAISKVGLLSAVpHMVMTIV-VPIGGQLADYLRSRKILTTtav 388
Cdd:cd17355 220 FLCGFAVVGLIV--------------HLVPYLAD-RGISPAAAAVALAL-IGLFNIVgRLLSGWLGDRYSPRRLLAA--- 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 389 rkimncgGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFA---ISGFNVNHLdIAPRYASILMGISNGVGTLSGMVCP 465
Cdd:cd17355 281 -------SYALRALGLALLLLLPFPPLALLLFAALFGLGWGAtvpLTAALAARY-FGARSYGTLFGLVFAPHQLGSALGP 352
|
....*.
gi 187663976 466 LIVGAM 471
Cdd:cd17355 353 WLGGLL 358
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
121-260 |
4.45e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 39.53 E-value: 4.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 121 QFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCV--RILQGLVEGV 198
Cdd:cd17345 32 QYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSSVGLMFilLFLNGWFQGM 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 187663976 199 TYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIG---WASVFYIYGMFGII 260
Cdd:cd17345 112 GWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFPAIIAII 176
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
329-436 |
7.50e-03 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 38.88 E-value: 7.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187663976 329 TFYLLLISQPAYFEEVFGFAISKvGLLSAVPHMV-MTIVVPIGGQLADYLRSRKILTTTAVRKI---------MNCGGFG 398
Cdd:cd17366 208 TNYMLLSYMPSYLEETLGYSETH-GLLVIIIIMVtMLVLQPFLGRLSDRVGRKPVYAAGLAGLLvlavpafllMNSGSIA 286
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 187663976 399 MEATLLLVVGFSHTKGVAISFLVL------AVGFSGFAIsGFNV 436
Cdd:cd17366 287 AIFIGLLVLGLLLSCYTATMASTLpalfptHVRYSALAI-AFNI 329
|
|
| |
