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Conserved domains on  [gi|296434484|sp|Q7L190|]
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RecName: Full=Developmental pluripotency-associated protein 4

Protein Classification

Dppa2_A and DCR domain-containing protein( domain architecture ID 10342306)

Dppa2_A and DCR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DCR pfam14047
Dppa2/4 conserved region; This domain has been characterized in the finding of a developmental ...
 227-294 8.26e-33

Dppa2/4 conserved region; This domain has been characterized in the finding of a developmental pluripotency associated gene (Dppa) in the lower vertebrate Xenopus laevis. Previous to this discovery, Dppa genes were known only in higher vertebrates. The domain is subject to structure determination by the Joint Center of Structural Genomics.


:

Pssm-ID: 464071  Cd Length: 67  Bit Score: 115.58  E-value: 8.26e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 296434484  227 GVRWCVVHGKSLPADTDGWVHLQFHAGQAWVPEKQeGRVSALFLLPASNFPPPHLEDNMLCPKCVHRN 294
Cdd:pfam14047   1 GKRWCVVHGALLPADPEGWVRLQFHGGQWWVPKTP-RRMISLFLLPACIFPPPGLEDNMLCPECVKRN 67
Dppa2_A super family cl16568
Dppa2/4 conserved region in higher vertebrates; Developmental pluripotency associated genes ...
 129-221 8.55e-10

Dppa2/4 conserved region in higher vertebrates; Developmental pluripotency associated genes (Dppa) in lower vertebrates have remained undetected until the discovery of a Dppa homolog in Xenopus laevis, reporting a new domain termed Dppa2/4 conserved region (DCR). In higher vertebrate Dppa proteins the DCR domain is located next to the here-reported domain. The domain is subject to structure determination by the Joint Center of Structural Genomics.


The actual alignment was detected with superfamily member pfam14049:

Pssm-ID: 433674  Cd Length: 85  Bit Score: 54.45  E-value: 8.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434484  129 QKDFPSTAKEAKIrKSLQKKLKVEKGETSLQSSETHPPEValppvgeppalenstallEGVNTVVVTTSAPEALLASWAR 208
Cdd:pfam14049   1 KCNIPETSREARL-QSCSRKGKMVTKRARPQKSCKMSERE------------------EETNVVEVITSAQEAMLAAWAR 61

                          90
                  ....*....|...
gi 296434484  209 ISARARTPEAVES 221
Cdd:pfam14049  62 IAARAGQPKAVNS 74
 
Name Accession Description Interval E-value
DCR pfam14047
Dppa2/4 conserved region; This domain has been characterized in the finding of a developmental ...
 227-294 8.26e-33

Dppa2/4 conserved region; This domain has been characterized in the finding of a developmental pluripotency associated gene (Dppa) in the lower vertebrate Xenopus laevis. Previous to this discovery, Dppa genes were known only in higher vertebrates. The domain is subject to structure determination by the Joint Center of Structural Genomics.


Pssm-ID: 464071  Cd Length: 67  Bit Score: 115.58  E-value: 8.26e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 296434484  227 GVRWCVVHGKSLPADTDGWVHLQFHAGQAWVPEKQeGRVSALFLLPASNFPPPHLEDNMLCPKCVHRN 294
Cdd:pfam14047   1 GKRWCVVHGALLPADPEGWVRLQFHGGQWWVPKTP-RRMISLFLLPACIFPPPGLEDNMLCPECVKRN 67
Dppa2_A pfam14049
Dppa2/4 conserved region in higher vertebrates; Developmental pluripotency associated genes ...
 129-221 8.55e-10

Dppa2/4 conserved region in higher vertebrates; Developmental pluripotency associated genes (Dppa) in lower vertebrates have remained undetected until the discovery of a Dppa homolog in Xenopus laevis, reporting a new domain termed Dppa2/4 conserved region (DCR). In higher vertebrate Dppa proteins the DCR domain is located next to the here-reported domain. The domain is subject to structure determination by the Joint Center of Structural Genomics.


Pssm-ID: 433674  Cd Length: 85  Bit Score: 54.45  E-value: 8.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434484  129 QKDFPSTAKEAKIrKSLQKKLKVEKGETSLQSSETHPPEValppvgeppalenstallEGVNTVVVTTSAPEALLASWAR 208
Cdd:pfam14049   1 KCNIPETSREARL-QSCSRKGKMVTKRARPQKSCKMSERE------------------EETNVVEVITSAQEAMLAAWAR 61

                          90
                  ....*....|...
gi 296434484  209 ISARARTPEAVES 221
Cdd:pfam14049  62 IAARAGQPKAVNS 74
 
Name Accession Description Interval E-value
DCR pfam14047
Dppa2/4 conserved region; This domain has been characterized in the finding of a developmental ...
 227-294 8.26e-33

Dppa2/4 conserved region; This domain has been characterized in the finding of a developmental pluripotency associated gene (Dppa) in the lower vertebrate Xenopus laevis. Previous to this discovery, Dppa genes were known only in higher vertebrates. The domain is subject to structure determination by the Joint Center of Structural Genomics.


Pssm-ID: 464071  Cd Length: 67  Bit Score: 115.58  E-value: 8.26e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 296434484  227 GVRWCVVHGKSLPADTDGWVHLQFHAGQAWVPEKQeGRVSALFLLPASNFPPPHLEDNMLCPKCVHRN 294
Cdd:pfam14047   1 GKRWCVVHGALLPADPEGWVRLQFHGGQWWVPKTP-RRMISLFLLPACIFPPPGLEDNMLCPECVKRN 67
Dppa2_A pfam14049
Dppa2/4 conserved region in higher vertebrates; Developmental pluripotency associated genes ...
 129-221 8.55e-10

Dppa2/4 conserved region in higher vertebrates; Developmental pluripotency associated genes (Dppa) in lower vertebrates have remained undetected until the discovery of a Dppa homolog in Xenopus laevis, reporting a new domain termed Dppa2/4 conserved region (DCR). In higher vertebrate Dppa proteins the DCR domain is located next to the here-reported domain. The domain is subject to structure determination by the Joint Center of Structural Genomics.


Pssm-ID: 433674  Cd Length: 85  Bit Score: 54.45  E-value: 8.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296434484  129 QKDFPSTAKEAKIrKSLQKKLKVEKGETSLQSSETHPPEValppvgeppalenstallEGVNTVVVTTSAPEALLASWAR 208
Cdd:pfam14049   1 KCNIPETSREARL-QSCSRKGKMVTKRARPQKSCKMSERE------------------EETNVVEVITSAQEAMLAAWAR 61

                          90
                  ....*....|...
gi 296434484  209 ISARARTPEAVES 221
Cdd:pfam14049  62 IAARAGQPKAVNS 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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