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Conserved domains on  [gi|81884527|sp|Q6AY59|]
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RecName: Full=Molybdopterin synthase catalytic subunit; AltName: Full=Molybdenum cofactor synthesis protein 2 large subunit; AltName: Full=Molybdenum cofactor synthesis protein 2B; Short=MOCS2B

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 65-189 4.42e-58

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


:

Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 178.48  E-value: 4.42e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81884527  65 LSVGEVSQLVVSPLCGAVSLFVGTTRNNFEGKKVISLEYEAYLPMAENEIRKICNDIRQKWPVRHIAVFHRLGLVPVSEA 144
Cdd:cd00756   1 FDLAELLAALRDPEAGAVVTFVGTVRDHDEGKGVEALEYEAYPPMAEKELEEIAEEARERWGLLRVAIIHRVGRLPPGEA 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 81884527 145 STVIAVSSAHRAASLEAVSYAIDSLKAKVPIWKKEIYEEStSSWK 189
Cdd:cd00756  81 IVLVAVSSPHRKEAFEACEFLIDRLKHRAPIWKKEIFEGG-EEWV 124
 
Name Accession Description Interval E-value
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 65-189 4.42e-58

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 178.48  E-value: 4.42e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81884527  65 LSVGEVSQLVVSPLCGAVSLFVGTTRNNFEGKKVISLEYEAYLPMAENEIRKICNDIRQKWPVRHIAVFHRLGLVPVSEA 144
Cdd:cd00756   1 FDLAELLAALRDPEAGAVVTFVGTVRDHDEGKGVEALEYEAYPPMAEKELEEIAEEARERWGLLRVAIIHRVGRLPPGEA 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 81884527 145 STVIAVSSAHRAASLEAVSYAIDSLKAKVPIWKKEIYEEStSSWK 189
Cdd:cd00756  81 IVLVAVSSPHRKEAFEACEFLIDRLKHRAPIWKKEIFEGG-EEWV 124
PLN02390 PLN02390
molybdopterin synthase catalytic subunit
 76-183 4.86e-57

molybdopterin synthase catalytic subunit


Pssm-ID: 178014  Cd Length: 111  Bit Score: 175.65  E-value: 4.86e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81884527   76 SPLCGAVSLFVGTTRNNFEGKKVISLEYEAYLPMAENEIRKICNDIRQKWPVRHIAVFHRLGLVPVSEASTVIAVSSAHR 155
Cdd:PLN02390   1 DPQAGAIATFSGTTRDTFEGKTVLELRYEAYVPMALRELRKICDEARSRWSLHKIAVAHRLGPVPVGETSVFVAVSSVHR 80

                         90       100
                 ....*....|....*....|....*...
gi 81884527  156 AASLEAVSYAIDSLKAKVPIWKKEIYEE 183
Cdd:PLN02390  81 ADALDACKFLIDELKASVPIWKKEVYDD 108
MoaE pfam02391
MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of ...
 61-172 4.75e-56

MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of molybdopterin. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.


Pssm-ID: 460546  Cd Length: 113  Bit Score: 173.02  E-value: 4.75e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81884527    61 TAKKLSVGEVSQLVVSPLCGAVSLFVGTTRNNFEGKKVISLEYEAYLPMAENEIRKICNDIRQKWPVRHIAVFHRLGLVP 140
Cdd:pfam02391   2 TEEPLDVAEIAALVSDPEAGAVVTFVGTVRDHFDGKKVTALEYEAYPPMAEKELAEIAEEARERWPLLDVAIVHRVGRLP 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 81884527   141 VSEASTVIAVSSAHRAASLEAVSYAIDSLKAK 172
Cdd:pfam02391  82 VGEAIVLVAVSSPHRAEAFEACEYLIDELKAR 113
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 55-194 5.03e-53

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 166.51  E-value: 5.03e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81884527  55 KDIIQFTAKKLSVGEVSQLVVS--PLCGAVSLFVGTTRNNFEGKKVISLEYEAYLPMAENEIRKICNDIRQKWPVRHIAV 132
Cdd:COG0314   1 MMRVRVTEEPFDLAAELAALRAsdPEAGAVVTFVGTVRDHNDGRRVTALEYEAYPPMAEKELAEIAEEAAERWGLLDVAV 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81884527 133 FHRLGLVPVSEASTVIAVSSAHRAASLEAVSYAIDSLKAKVPIWKKEIYEEStSSWKRNKEC 194
Cdd:COG0314  81 IHRVGRLEPGEPIVLVAVSSAHRKEAFEACRFLIDRLKTRAPIWKKEIFEDG-EEWVEARSS 141
 
Name Accession Description Interval E-value
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 65-189 4.42e-58

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 178.48  E-value: 4.42e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81884527  65 LSVGEVSQLVVSPLCGAVSLFVGTTRNNFEGKKVISLEYEAYLPMAENEIRKICNDIRQKWPVRHIAVFHRLGLVPVSEA 144
Cdd:cd00756   1 FDLAELLAALRDPEAGAVVTFVGTVRDHDEGKGVEALEYEAYPPMAEKELEEIAEEARERWGLLRVAIIHRVGRLPPGEA 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 81884527 145 STVIAVSSAHRAASLEAVSYAIDSLKAKVPIWKKEIYEEStSSWK 189
Cdd:cd00756  81 IVLVAVSSPHRKEAFEACEFLIDRLKHRAPIWKKEIFEGG-EEWV 124
PLN02390 PLN02390
molybdopterin synthase catalytic subunit
 76-183 4.86e-57

molybdopterin synthase catalytic subunit


Pssm-ID: 178014  Cd Length: 111  Bit Score: 175.65  E-value: 4.86e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81884527   76 SPLCGAVSLFVGTTRNNFEGKKVISLEYEAYLPMAENEIRKICNDIRQKWPVRHIAVFHRLGLVPVSEASTVIAVSSAHR 155
Cdd:PLN02390   1 DPQAGAIATFSGTTRDTFEGKTVLELRYEAYVPMALRELRKICDEARSRWSLHKIAVAHRLGPVPVGETSVFVAVSSVHR 80

                         90       100
                 ....*....|....*....|....*...
gi 81884527  156 AASLEAVSYAIDSLKAKVPIWKKEIYEE 183
Cdd:PLN02390  81 ADALDACKFLIDELKASVPIWKKEVYDD 108
MoaE pfam02391
MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of ...
 61-172 4.75e-56

MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of molybdopterin. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.


Pssm-ID: 460546  Cd Length: 113  Bit Score: 173.02  E-value: 4.75e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81884527    61 TAKKLSVGEVSQLVVSPLCGAVSLFVGTTRNNFEGKKVISLEYEAYLPMAENEIRKICNDIRQKWPVRHIAVFHRLGLVP 140
Cdd:pfam02391   2 TEEPLDVAEIAALVSDPEAGAVVTFVGTVRDHFDGKKVTALEYEAYPPMAEKELAEIAEEARERWPLLDVAIVHRVGRLP 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 81884527   141 VSEASTVIAVSSAHRAASLEAVSYAIDSLKAK 172
Cdd:pfam02391  82 VGEAIVLVAVSSPHRAEAFEACEYLIDELKAR 113
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 55-194 5.03e-53

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 166.51  E-value: 5.03e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81884527  55 KDIIQFTAKKLSVGEVSQLVVS--PLCGAVSLFVGTTRNNFEGKKVISLEYEAYLPMAENEIRKICNDIRQKWPVRHIAV 132
Cdd:COG0314   1 MMRVRVTEEPFDLAAELAALRAsdPEAGAVVTFVGTVRDHNDGRRVTALEYEAYPPMAEKELAEIAEEAAERWGLLDVAV 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81884527 133 FHRLGLVPVSEASTVIAVSSAHRAASLEAVSYAIDSLKAKVPIWKKEIYEEStSSWKRNKEC 194
Cdd:COG0314  81 IHRVGRLEPGEPIVLVAVSSAHRKEAFEACRFLIDRLKTRAPIWKKEIFEDG-EEWVEARSS 141
moaE PRK10678
molybdopterin synthase catalytic subunit MoaE;
58-179 1.00e-21

molybdopterin synthase catalytic subunit MoaE;


Pssm-ID: 182642  Cd Length: 150  Bit Score: 86.72  E-value: 1.00e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81884527   58 IQFTAKKLSVGEVSQ-LVVSPLCGAVSLFVGTTRNNFEGKKVISLEYEAYLPMAENEIRKICNDIRQKWPVRHIAVFHRL 136
Cdd:PRK10678   6 IVVGPAPFSVGEEYPwLAERDEDGAVVTFTGKVRNHNLGDSVKALTLEHYPGMTEKALAEIVDEARSRWPLGRVTVIHRV 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 81884527  137 GLVPVSEASTVIAVSSAHRAASLEAVSYAIDSLKAKVPIWKKE 179
Cdd:PRK10678  86 GELWPGDEIVFVGVTSAHRSSAFEAGQFIMDYLKTRAPFWKRE 128
PRK14493 PRK14493
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; ...
 76-199 3.80e-18

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; Provisional


Pssm-ID: 237730 [Multi-domain]  Cd Length: 274  Bit Score: 79.66  E-value: 3.80e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81884527   76 SPLCGAVSLFVGTTRNN--FEGKKVISLEYEAYLPMAENEIRKICNDIRQKWPVRHIAVFHRLGLVPVSEASTVIAVSSA 153
Cdd:PRK14493 156 ADKAGAIATFTGRVRAKedADDEPTEYLEFEKYDGVADERMAAIREELKQRDGVFEVLLHHRTGVIEAGEDIVFVVVLAG 235

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 81884527  154 HRAASLEAVSYAIDSLKAKVPIWKKEIYEEstsswkrnkECFWAAD 199
Cdd:PRK14493 236 HRQEAFRAVSDGIDRLKDEVPIFKKEVTVD---------EEFWVHD 272
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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