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Conserved domains on  [gi|74747583|sp|Q5VXU1|]
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RecName: Full=Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2; Short=Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 2; AltName: Full=Protein FAM77B; AltName: Full=T-cell lymphoma breakpoint-associated target protein 1

Protein Classification

NKAIN domain-containing protein( domain architecture ID 10528994)

NKAIN domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NKAIN pfam05640
Na,K-Atpase Interacting protein; NKAIN (Na,K-Atpase INteracting) proteins are a family of ...
 1-207 1.84e-128

Na,K-Atpase Interacting protein; NKAIN (Na,K-Atpase INteracting) proteins are a family of evolutionary conserved transmembrane proteins that localize to neurons, that are critical for neuronal function, and that interact with the beta subunits, beta1 in vertebrates and beta in Drosophila, of Na,K-ATPase. NKAINs have highly conserved trans-membrane domains but otherwise no other characterized domains. NKAINs may function as subunits of pore or channel structures in neurons or they may affect the function of other membrane proteins. They are likely to function within the membrane bilayer.


:

Pssm-ID: 461699  Cd Length: 206  Bit Score: 360.26  E-value: 1.84e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74747583     1 MGYCSGRCTLIFICGMQLVCVLERQIFDFLGYQWAPILANFVHIIIVILGLFGTIQYRPRYITGYAVWLVLWVTWNVFVI 80
Cdd:pfam05640   1 MGCCSGRCTLIFFCFLQLLAVLERQVFDFLGYQWAPILVNFFHIIFVILGLFGTIQYRPRYLVVYAVWLVLWVGWNIFII 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74747583    81 CFYLEAGDLSKETDLiLTFNISMHRSWWMENGPGCTVTSVTPAPDWAPEDHRYITVSGCLLEYQYIEVAHSSLQIVLALA 160
Cdd:pfam05640  81 CFYLEVGILSRDSDL-LTFNTSQHRSWWMENGPGCRVTPPTITSEDAPEDHRYISVSGCLLDYQYIEVVHSAIQILLALV 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 74747583   161 GFIYACYVVKCITEEEDSFDFIGGFDSYGYQGPQKTSHLQLQPMYMS 207
Cdd:pfam05640 160 GFIYACYVVKTFLEEEDSFDFIGGFDSYGYQAPQKTSHLQLQPMYVS 206
 
Name Accession Description Interval E-value
NKAIN pfam05640
Na,K-Atpase Interacting protein; NKAIN (Na,K-Atpase INteracting) proteins are a family of ...
 1-207 1.84e-128

Na,K-Atpase Interacting protein; NKAIN (Na,K-Atpase INteracting) proteins are a family of evolutionary conserved transmembrane proteins that localize to neurons, that are critical for neuronal function, and that interact with the beta subunits, beta1 in vertebrates and beta in Drosophila, of Na,K-ATPase. NKAINs have highly conserved trans-membrane domains but otherwise no other characterized domains. NKAINs may function as subunits of pore or channel structures in neurons or they may affect the function of other membrane proteins. They are likely to function within the membrane bilayer.


Pssm-ID: 461699  Cd Length: 206  Bit Score: 360.26  E-value: 1.84e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74747583     1 MGYCSGRCTLIFICGMQLVCVLERQIFDFLGYQWAPILANFVHIIIVILGLFGTIQYRPRYITGYAVWLVLWVTWNVFVI 80
Cdd:pfam05640   1 MGCCSGRCTLIFFCFLQLLAVLERQVFDFLGYQWAPILVNFFHIIFVILGLFGTIQYRPRYLVVYAVWLVLWVGWNIFII 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74747583    81 CFYLEAGDLSKETDLiLTFNISMHRSWWMENGPGCTVTSVTPAPDWAPEDHRYITVSGCLLEYQYIEVAHSSLQIVLALA 160
Cdd:pfam05640  81 CFYLEVGILSRDSDL-LTFNTSQHRSWWMENGPGCRVTPPTITSEDAPEDHRYISVSGCLLDYQYIEVVHSAIQILLALV 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 74747583   161 GFIYACYVVKCITEEEDSFDFIGGFDSYGYQGPQKTSHLQLQPMYMS 207
Cdd:pfam05640 160 GFIYACYVVKTFLEEEDSFDFIGGFDSYGYQAPQKTSHLQLQPMYVS 206
 
Name Accession Description Interval E-value
NKAIN pfam05640
Na,K-Atpase Interacting protein; NKAIN (Na,K-Atpase INteracting) proteins are a family of ...
 1-207 1.84e-128

Na,K-Atpase Interacting protein; NKAIN (Na,K-Atpase INteracting) proteins are a family of evolutionary conserved transmembrane proteins that localize to neurons, that are critical for neuronal function, and that interact with the beta subunits, beta1 in vertebrates and beta in Drosophila, of Na,K-ATPase. NKAINs have highly conserved trans-membrane domains but otherwise no other characterized domains. NKAINs may function as subunits of pore or channel structures in neurons or they may affect the function of other membrane proteins. They are likely to function within the membrane bilayer.


Pssm-ID: 461699  Cd Length: 206  Bit Score: 360.26  E-value: 1.84e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74747583     1 MGYCSGRCTLIFICGMQLVCVLERQIFDFLGYQWAPILANFVHIIIVILGLFGTIQYRPRYITGYAVWLVLWVTWNVFVI 80
Cdd:pfam05640   1 MGCCSGRCTLIFFCFLQLLAVLERQVFDFLGYQWAPILVNFFHIIFVILGLFGTIQYRPRYLVVYAVWLVLWVGWNIFII 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74747583    81 CFYLEAGDLSKETDLiLTFNISMHRSWWMENGPGCTVTSVTPAPDWAPEDHRYITVSGCLLEYQYIEVAHSSLQIVLALA 160
Cdd:pfam05640  81 CFYLEVGILSRDSDL-LTFNTSQHRSWWMENGPGCRVTPPTITSEDAPEDHRYISVSGCLLDYQYIEVVHSAIQILLALV 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 74747583   161 GFIYACYVVKCITEEEDSFDFIGGFDSYGYQGPQKTSHLQLQPMYMS 207
Cdd:pfam05640 160 GFIYACYVVKTFLEEEDSFDFIGGFDSYGYQAPQKTSHLQLQPMYVS 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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