NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|296439285|sp|Q14207|]
View 

RecName: Full=Protein NPAT; AltName: Full=Nuclear protein of the ataxia telangiectasia mutated locus; Short=Nuclear protein of the ATM locus; AltName: Full=p220

Protein Classification

LisH domain-containing protein( domain architecture ID 12174358)

LisH domain-containing protein; LisH domain-containing protein similar to Homo sapiens single-stranded DNA-binding protein 2 (SSBP2), a tumor suppressor implicated in multiple cancer forms

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NPAT_C pfam15712
NPAT C terminus;
758-1427 0e+00

NPAT C terminus;


:

Pssm-ID: 434876 [Multi-domain]  Cd Length: 680  Bit Score: 1049.50  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285   758 SAVSSINGENLPTIILSSPTKSPTKNAELVKCLSSEETVGAVVYAE-VGDSASMEQSLLTFKSEDSAVNNTQNEDGIAFS 836
Cdd:pfam15712    1 SAVSSISGENLPTIILSSPAKSPAKNAELVKCLSSEETAGAVVSAErVGDSASVEQSLLVLKPEDSAANNTQNEECTAFS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285   837 ANVTPCVSKDGGYIQLMPATSTAFGNSNNILIATCVTDPTALGTSVSQSNVVVLPGNSAPMTAQPLPPQL-QTPPRSNSV 915
Cdd:pfam15712   81 ANGTPCVSKDGGFIQLMPATSTTFGNSNNILIATCVTDPTALGTTVTQSNVVVLPGNSAPMASQPPPPQQlQTPPRSNSV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285   916 FAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNNFSTPPRQVLHMPLTAPVCNRSIPQFPVPPKSQKAQ 995
Cdd:pfam15712  161 FTVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNAFSAPSQQVLHMPLAAPVCNRSIPKLPIPPKSQKAQ 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285   996 GLRNKPCIGKQVNNLVDSSGHSVGCHAQKTEVSDKSIATDLGKKSEETTVPFPEESIVPAAKP--CHRRVLCFD-STTAP 1072
Cdd:pfam15712  241 GLRNKPCTGKQVNSLTDSSSHPVGSHAQRTEVSDKNMATDLGKKLEETTVPFSTESTVPSSKPfeSHRRVLCFDsSTTSP 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285  1073 VANTQGPNHKMVSQNKERNAVSFPNLDSPNVSSTLkPPSNNAIKREKEKPPLPKILSKSESAISRHTTIRETQSEKKVSP 1152
Cdd:pfam15712  321 VANTQGSNHKMTSQNKERNEISFSTLDSPGASSAL-LPSNNSSKREREKPPLPKILSKSEVASSRHTAVKETQSEKKVSP 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285  1153 TEIVLESFHKATANKENELCSDVERQKNPENSKLSIGQQNGGLRSEKSIASLQEMTKKQGTSSNNKNvlSVGTAVKDLKQ 1232
Cdd:pfam15712  400 TELVLESFHKATANKENELCSDVERQKNQETSKLSVGQQNGGLRNEKAIASLQELTKKQGTSSNSKN--SVGTPSKDPKQ 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285  1233 EQTKSASSL---------ITTEMLQDIQRHSSVSRLADSSDLPVPRTPGSGAGEKHKEEPIDIIKAPSSRRFSEDSSTSK 1303
Cdd:pfam15712  478 EQTKSASERmsltsplakQATEMLHDIQWQSPASKLPDSGDLPVPRTPGSGAGDKHKEEPSDGIKTPSSRRYSEDGSTPK 557

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285  1304 VMVPPVTPDLPACSPASETGSENSVNMAAHTLMILSRAAISRTTSATPLKDNTQQFRaSSRSTTKKRKIEELDERERNSR 1383
Cdd:pfam15712  558 VMVPPATPDLPACSPASETGSENSVNMAAHTLMILSRAAIARTTSTTPLKDNTQQFR-SSRSTTKKRKLEELDECERNSR 636

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....
gi 296439285  1384 PSSKNLTNSSIPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE 1427
Cdd:pfam15712  637 PSKKDLQNSSVPMKKKKIKKKKLPDSFPAGMDVDKFLLSLHYDE 680
 
Name Accession Description Interval E-value
NPAT_C pfam15712
NPAT C terminus;
758-1427 0e+00

NPAT C terminus;


Pssm-ID: 434876 [Multi-domain]  Cd Length: 680  Bit Score: 1049.50  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285   758 SAVSSINGENLPTIILSSPTKSPTKNAELVKCLSSEETVGAVVYAE-VGDSASMEQSLLTFKSEDSAVNNTQNEDGIAFS 836
Cdd:pfam15712    1 SAVSSISGENLPTIILSSPAKSPAKNAELVKCLSSEETAGAVVSAErVGDSASVEQSLLVLKPEDSAANNTQNEECTAFS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285   837 ANVTPCVSKDGGYIQLMPATSTAFGNSNNILIATCVTDPTALGTSVSQSNVVVLPGNSAPMTAQPLPPQL-QTPPRSNSV 915
Cdd:pfam15712   81 ANGTPCVSKDGGFIQLMPATSTTFGNSNNILIATCVTDPTALGTTVTQSNVVVLPGNSAPMASQPPPPQQlQTPPRSNSV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285   916 FAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNNFSTPPRQVLHMPLTAPVCNRSIPQFPVPPKSQKAQ 995
Cdd:pfam15712  161 FTVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNAFSAPSQQVLHMPLAAPVCNRSIPKLPIPPKSQKAQ 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285   996 GLRNKPCIGKQVNNLVDSSGHSVGCHAQKTEVSDKSIATDLGKKSEETTVPFPEESIVPAAKP--CHRRVLCFD-STTAP 1072
Cdd:pfam15712  241 GLRNKPCTGKQVNSLTDSSSHPVGSHAQRTEVSDKNMATDLGKKLEETTVPFSTESTVPSSKPfeSHRRVLCFDsSTTSP 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285  1073 VANTQGPNHKMVSQNKERNAVSFPNLDSPNVSSTLkPPSNNAIKREKEKPPLPKILSKSESAISRHTTIRETQSEKKVSP 1152
Cdd:pfam15712  321 VANTQGSNHKMTSQNKERNEISFSTLDSPGASSAL-LPSNNSSKREREKPPLPKILSKSEVASSRHTAVKETQSEKKVSP 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285  1153 TEIVLESFHKATANKENELCSDVERQKNPENSKLSIGQQNGGLRSEKSIASLQEMTKKQGTSSNNKNvlSVGTAVKDLKQ 1232
Cdd:pfam15712  400 TELVLESFHKATANKENELCSDVERQKNQETSKLSVGQQNGGLRNEKAIASLQELTKKQGTSSNSKN--SVGTPSKDPKQ 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285  1233 EQTKSASSL---------ITTEMLQDIQRHSSVSRLADSSDLPVPRTPGSGAGEKHKEEPIDIIKAPSSRRFSEDSSTSK 1303
Cdd:pfam15712  478 EQTKSASERmsltsplakQATEMLHDIQWQSPASKLPDSGDLPVPRTPGSGAGDKHKEEPSDGIKTPSSRRYSEDGSTPK 557

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285  1304 VMVPPVTPDLPACSPASETGSENSVNMAAHTLMILSRAAISRTTSATPLKDNTQQFRaSSRSTTKKRKIEELDERERNSR 1383
Cdd:pfam15712  558 VMVPPATPDLPACSPASETGSENSVNMAAHTLMILSRAAIARTTSTTPLKDNTQQFR-SSRSTTKKRKLEELDECERNSR 636

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....
gi 296439285  1384 PSSKNLTNSSIPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE 1427
Cdd:pfam15712  637 PSKKDLQNSSVPMKKKKIKKKKLPDSFPAGMDVDKFLLSLHYDE 680
 
Name Accession Description Interval E-value
NPAT_C pfam15712
NPAT C terminus;
758-1427 0e+00

NPAT C terminus;


Pssm-ID: 434876 [Multi-domain]  Cd Length: 680  Bit Score: 1049.50  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285   758 SAVSSINGENLPTIILSSPTKSPTKNAELVKCLSSEETVGAVVYAE-VGDSASMEQSLLTFKSEDSAVNNTQNEDGIAFS 836
Cdd:pfam15712    1 SAVSSISGENLPTIILSSPAKSPAKNAELVKCLSSEETAGAVVSAErVGDSASVEQSLLVLKPEDSAANNTQNEECTAFS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285   837 ANVTPCVSKDGGYIQLMPATSTAFGNSNNILIATCVTDPTALGTSVSQSNVVVLPGNSAPMTAQPLPPQL-QTPPRSNSV 915
Cdd:pfam15712   81 ANGTPCVSKDGGFIQLMPATSTTFGNSNNILIATCVTDPTALGTTVTQSNVVVLPGNSAPMASQPPPPQQlQTPPRSNSV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285   916 FAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNNFSTPPRQVLHMPLTAPVCNRSIPQFPVPPKSQKAQ 995
Cdd:pfam15712  161 FTVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIPVSVVGQNGNAFSAPSQQVLHMPLAAPVCNRSIPKLPIPPKSQKAQ 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285   996 GLRNKPCIGKQVNNLVDSSGHSVGCHAQKTEVSDKSIATDLGKKSEETTVPFPEESIVPAAKP--CHRRVLCFD-STTAP 1072
Cdd:pfam15712  241 GLRNKPCTGKQVNSLTDSSSHPVGSHAQRTEVSDKNMATDLGKKLEETTVPFSTESTVPSSKPfeSHRRVLCFDsSTTSP 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285  1073 VANTQGPNHKMVSQNKERNAVSFPNLDSPNVSSTLkPPSNNAIKREKEKPPLPKILSKSESAISRHTTIRETQSEKKVSP 1152
Cdd:pfam15712  321 VANTQGSNHKMTSQNKERNEISFSTLDSPGASSAL-LPSNNSSKREREKPPLPKILSKSEVASSRHTAVKETQSEKKVSP 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285  1153 TEIVLESFHKATANKENELCSDVERQKNPENSKLSIGQQNGGLRSEKSIASLQEMTKKQGTSSNNKNvlSVGTAVKDLKQ 1232
Cdd:pfam15712  400 TELVLESFHKATANKENELCSDVERQKNQETSKLSVGQQNGGLRNEKAIASLQELTKKQGTSSNSKN--SVGTPSKDPKQ 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285  1233 EQTKSASSL---------ITTEMLQDIQRHSSVSRLADSSDLPVPRTPGSGAGEKHKEEPIDIIKAPSSRRFSEDSSTSK 1303
Cdd:pfam15712  478 EQTKSASERmsltsplakQATEMLHDIQWQSPASKLPDSGDLPVPRTPGSGAGDKHKEEPSDGIKTPSSRRYSEDGSTPK 557

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296439285  1304 VMVPPVTPDLPACSPASETGSENSVNMAAHTLMILSRAAISRTTSATPLKDNTQQFRaSSRSTTKKRKIEELDERERNSR 1383
Cdd:pfam15712  558 VMVPPATPDLPACSPASETGSENSVNMAAHTLMILSRAAIARTTSTTPLKDNTQQFR-SSRSTTKKRKLEELDECERNSR 636

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....
gi 296439285  1384 PSSKNLTNSSIPMKKKKIKKKKLPSSFPAGMDVDKFLLSLHYDE 1427
Cdd:pfam15712  637 PSKKDLQNSSVPMKKKKIKKKKLPDSFPAGMDVDKFLLSLHYDE 680
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH