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Conserved domains on  [gi|399505|sp|Q01740|]
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RecName: Full=Flavin-containing monooxygenase 1; AltName: Full=Dimethylaniline monooxygenase [N-oxide-forming] 1; AltName: Full=Dimethylaniline oxidase 1; AltName: Full=Fetal hepatic flavin-containing monooxygenase 1; Short=FMO 1; AltName: Full=Trimethylamine monooxygenase

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
2-531 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


:

Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 1021.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505       2 AKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEGRASLYKSVVSNSCKEMSCYSDFPFPEDYPNY 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505      82 VPNSQFLEYLKMYANHFDLLKHIQFKTKVCSVTKCSDSAVSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFP 161
Cdd:pfam00743  81 MHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     162 GINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQN 241
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     242 MLRNSLPTPIVTWLMERKINNWLNHANYGLIPEDRTQLKEFVLNDELPGRIITGKVFIRPSIKEVKENSVIFNNTSKEEP 321
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     322 IDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAHLQKPTLAIIGLIKPLGSMIPTGETQARWAVRVLKGVNKLPP 401
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     402 PSVMIEEINARKENKPSWFGLCYCKALQSDYITYIDELLTYINAKPNLFSMLLTDPHLALTVFFGPCSPYQFRLTGPGKW 481
Cdd:pfam00743 401 QSEMMAEINKRQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 399505     482 EGARNAIMTQWDRTFKVIKARVVQESPSPFESF-LKVFSFLALLVAIFLIF 531
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPASSFtLKIFGLPVVLVAIFLIL 531
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
2-531 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 1021.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505       2 AKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEGRASLYKSVVSNSCKEMSCYSDFPFPEDYPNY 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505      82 VPNSQFLEYLKMYANHFDLLKHIQFKTKVCSVTKCSDSAVSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFP 161
Cdd:pfam00743  81 MHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     162 GINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQN 241
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     242 MLRNSLPTPIVTWLMERKINNWLNHANYGLIPEDRTQLKEFVLNDELPGRIITGKVFIRPSIKEVKENSVIFNNTSKEEP 321
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     322 IDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAHLQKPTLAIIGLIKPLGSMIPTGETQARWAVRVLKGVNKLPP 401
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     402 PSVMIEEINARKENKPSWFGLCYCKALQSDYITYIDELLTYINAKPNLFSMLLTDPHLALTVFFGPCSPYQFRLTGPGKW 481
Cdd:pfam00743 401 QSEMMAEINKRQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 399505     482 EGARNAIMTQWDRTFKVIKARVVQESPSPFESF-LKVFSFLALLVAIFLIF 531
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPASSFtLKIFGLPVVLVAIFLIL 531
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
4-394 3.35e-86

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 272.12  E-value: 3.35e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     4 RVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEhveegraslYKSVVSNSCKEMSCYSDFPFPEDYPNYVP 83
Cdd:COG2072   8 DVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRDNR---------YPGLRLDTPSHLYSLPFFPNWSDDPDFPT 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505    84 NSQFLEYLKMYANHFDLLKHIQFKTKVCSVTKCSDSavsGQWEVVTmheEKQESAIFDAVMVCTGFLTNPYLPldSFPGI 163
Cdd:COG2072  79 GDEILAYLEAYADKFGLRRPIRFGTEVTSARWDEAD---GRWTVTT---DDGETLTARFVVVATGPLSRPKIP--DIPGL 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505   164 NAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRifdSGYPWDmvfMTRFQNML 243
Cdd:COG2072 151 EDFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPR---PNYDPE---RGRPANYL 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505   244 RNSLPTPI----VTWLMERKINNWLNHANYGLIPEDRTQL-KEFVLNDELPGRIITGKV-FIRPSIKEVKENSVIFNNtS 317
Cdd:COG2072 225 GLEAPPALnrrdARAWLRRLLRAQVKDPELGLLTPDYPPGcKRPLLSTDYYEALRRGNVeLVTGGIERITEDGVVFAD-G 303
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505   318 KEEPIDIIVFATGYTFAFPFLDESVVKVEDGQAS--LYKYIFPAHLqkPTLAIIGLIKPLG--SMIPTGETQARWAVRVL 393
Cdd:COG2072 304 TEHEVDVIVWATGFRADLPWLAPLDVRGRDGRSGprAYLGVVVPGF--PNLFFLGPNSPSGhsSLTLGAERQARYIARLI 381

                .
gi 399505   394 K 394
Cdd:COG2072 382 A 382
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
2-439 5.58e-41

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 153.48  E-value: 5.58e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505      2 AKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEG-----------RASLYKSVVSNSCKEMSCYS 70
Cdd:PLN02172  10 SQHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTPKSESDplsldptrsivHSSVYESLRTNLPRECMGYR 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     71 DFPF----------PEDYPNYvpnSQFLEYLKMYANHFDLLKHIQFKTKVCSVtkcsdSAVSGQWEVVTMHEEK-QESAI 139
Cdd:PLN02172  90 DFPFvprfddesrdSRRYPSH---REVLAYLQDFAREFKIEEMVRFETEVVRV-----EPVDGKWRVQSKNSGGfSKDEI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505    140 FDAVMVCTGFLTNPYLPldSFPGINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSttgggw 219
Cdd:PLN02172 162 FDAVVVCNGHYTEPNVA--HIPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIA------ 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505    220 viSRIFDSGypwdmvfmtrfqnmLRNSLPTPivtwlmerkINNWLNHANYGLIPEDrtqlkefvlndelpgriitgkvfi 299
Cdd:PLN02172 234 --SRASESD--------------TYEKLPVP---------QNNLWMHSEIDTAHED------------------------ 264
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505    300 rpsikevkeNSVIFNNtSKEEPIDIIVFATGYTFAFPFLDES-VVKVEDGQAS-LYKYIFPAHLqKPTLAIIGLiKPLGS 377
Cdd:PLN02172 265 ---------GSIVFKN-GKVVYADTIVHCTGYKYHFPFLETNgYMRIDENRVEpLYKHVFPPAL-APGLSFIGL-PAMGI 332
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 399505    378 MIPTGETQARWAVRVLKGVNKLPPPSVMIEEINARKENKPSwFGLC--YCKAL---QSDYITYIDEL 439
Cdd:PLN02172 333 QFVMFEIQSKWVAAVLSGRVTLPSEDKMMEDINAWYASLEA-LGIPkrYTHKLgkiQSEYLNWIAEE 398
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
2-531 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 1021.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505       2 AKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEGRASLYKSVVSNSCKEMSCYSDFPFPEDYPNY 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505      82 VPNSQFLEYLKMYANHFDLLKHIQFKTKVCSVTKCSDSAVSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFP 161
Cdd:pfam00743  81 MHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     162 GINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQN 241
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     242 MLRNSLPTPIVTWLMERKINNWLNHANYGLIPEDRTQLKEFVLNDELPGRIITGKVFIRPSIKEVKENSVIFNNTSKEEP 321
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     322 IDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAHLQKPTLAIIGLIKPLGSMIPTGETQARWAVRVLKGVNKLPP 401
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     402 PSVMIEEINARKENKPSWFGLCYCKALQSDYITYIDELLTYINAKPNLFSMLLTDPHLALTVFFGPCSPYQFRLTGPGKW 481
Cdd:pfam00743 401 QSEMMAEINKRQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 399505     482 EGARNAIMTQWDRTFKVIKARVVQESPSPFESF-LKVFSFLALLVAIFLIF 531
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPASSFtLKIFGLPVVLVAIFLIL 531
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
4-394 3.35e-86

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 272.12  E-value: 3.35e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     4 RVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEhveegraslYKSVVSNSCKEMSCYSDFPFPEDYPNYVP 83
Cdd:COG2072   8 DVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRDNR---------YPGLRLDTPSHLYSLPFFPNWSDDPDFPT 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505    84 NSQFLEYLKMYANHFDLLKHIQFKTKVCSVTKCSDSavsGQWEVVTmheEKQESAIFDAVMVCTGFLTNPYLPldSFPGI 163
Cdd:COG2072  79 GDEILAYLEAYADKFGLRRPIRFGTEVTSARWDEAD---GRWTVTT---DDGETLTARFVVVATGPLSRPKIP--DIPGL 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505   164 NAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRifdSGYPWDmvfMTRFQNML 243
Cdd:COG2072 151 EDFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPR---PNYDPE---RGRPANYL 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505   244 RNSLPTPI----VTWLMERKINNWLNHANYGLIPEDRTQL-KEFVLNDELPGRIITGKV-FIRPSIKEVKENSVIFNNtS 317
Cdd:COG2072 225 GLEAPPALnrrdARAWLRRLLRAQVKDPELGLLTPDYPPGcKRPLLSTDYYEALRRGNVeLVTGGIERITEDGVVFAD-G 303
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505   318 KEEPIDIIVFATGYTFAFPFLDESVVKVEDGQAS--LYKYIFPAHLqkPTLAIIGLIKPLG--SMIPTGETQARWAVRVL 393
Cdd:COG2072 304 TEHEVDVIVWATGFRADLPWLAPLDVRGRDGRSGprAYLGVVVPGF--PNLFFLGPNSPSGhsSLTLGAERQARYIARLI 381

                .
gi 399505   394 K 394
Cdd:COG2072 382 A 382
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
2-439 5.58e-41

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 153.48  E-value: 5.58e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505      2 AKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEG-----------RASLYKSVVSNSCKEMSCYS 70
Cdd:PLN02172  10 SQHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTPKSESDplsldptrsivHSSVYESLRTNLPRECMGYR 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     71 DFPF----------PEDYPNYvpnSQFLEYLKMYANHFDLLKHIQFKTKVCSVtkcsdSAVSGQWEVVTMHEEK-QESAI 139
Cdd:PLN02172  90 DFPFvprfddesrdSRRYPSH---REVLAYLQDFAREFKIEEMVRFETEVVRV-----EPVDGKWRVQSKNSGGfSKDEI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505    140 FDAVMVCTGFLTNPYLPldSFPGINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSttgggw 219
Cdd:PLN02172 162 FDAVVVCNGHYTEPNVA--HIPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIA------ 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505    220 viSRIFDSGypwdmvfmtrfqnmLRNSLPTPivtwlmerkINNWLNHANYGLIPEDrtqlkefvlndelpgriitgkvfi 299
Cdd:PLN02172 234 --SRASESD--------------TYEKLPVP---------QNNLWMHSEIDTAHED------------------------ 264
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505    300 rpsikevkeNSVIFNNtSKEEPIDIIVFATGYTFAFPFLDES-VVKVEDGQAS-LYKYIFPAHLqKPTLAIIGLiKPLGS 377
Cdd:PLN02172 265 ---------GSIVFKN-GKVVYADTIVHCTGYKYHFPFLETNgYMRIDENRVEpLYKHVFPPAL-APGLSFIGL-PAMGI 332
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 399505    378 MIPTGETQARWAVRVLKGVNKLPPPSVMIEEINARKENKPSwFGLC--YCKAL---QSDYITYIDEL 439
Cdd:PLN02172 333 QFVMFEIQSKWVAAVLSGRVTLPSEDKMMEDINAWYASLEA-LGIPkrYTHKLgkiQSEYLNWIAEE 398
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
72-352 4.13e-19

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 87.66  E-value: 4.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505      72 FPFPEDYPNyvpNSQFLEYLKMYANHFDLlkHIQFKTKVCSVTKcsdsaVSGQWEVVTMHEEkqesaiFDA--VMVCTGF 149
Cdd:pfam13738  65 FTFNREHPS---GNEYAEYLRRVADHFEL--PINLFEEVTSVKK-----EDDGFVVTTSKGT------YQAryVIIATGE 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     150 LTNPYLPLDSFPGInafkgqyfHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEashLAEKvflsttgGGWVisRIFDSGY 229
Cdd:pfam13738 129 FDFPNKLGVPELPK--------HYSYVKDFHPYAGQKVVVIGGYNSAVDAALE---LVRK-------GARV--TVLYRGS 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     230 PWDmvfmtrfqnmlrnslptpivtwlmerkinNWLNHANYGLIPEDRTQLKEFVLNdelpGRIitgKVFIRPSIKEVKEN 309
Cdd:pfam13738 189 EWE-----------------------------DRDSDPSYSLSPDTLNRLEELVKN----GKI---KAHFNAEVKEITEV 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 399505     310 S----VIFNNTSKEEPIDIIVFATGYTFAFPFLDESVVKV-EDGQASL 352
Cdd:pfam13738 233 DvsykVHTEDGRKVTSNDDPILATGYHPDLSFLKKGLFELdEDGRPVL 280
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
3-203 7.20e-07

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 51.67  E-value: 7.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     3 KRVAIVGAGVSGLAsikcC----LEEGLEPTCFERSDDLGGLWRF--TEHveegRasLYKSVVSnscKEMscysdfpfpe 76
Cdd:COG0493 122 KKVAVVGSGPAGLA----AayqlARAGHEVTVFEALDKPGGLLRYgiPEF----R--LPKDVLD---REI---------- 178
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505    77 dypnyvpnsQFLEylKMyanhfdllkHIQFKTKVcsvtkcsdsavsgqwEV---VTMHEEKQEsaiFDAVMVCTGFLTNP 153
Cdd:COG0493 179 ---------ELIE--AL---------GVEFRTNV---------------EVgkdITLDELLEE---FDAVFLATGAGKPR 220
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 399505   154 YLPLdsfPGINAfKGQYF------HSRQYKHPD--IFKDKRVLVIGMGNSGTDIAVEA 203
Cdd:COG0493 221 DLGI---PGEDL-KGVHSamdfltAVNLGEAPDtiLAVGKRVVVIGGGNTAMDCARTA 274
Lys_Orn_oxgnase pfam13434
L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold ...
81-333 4.89e-06

L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold oxidoreductases that catalyze NADPH-dependent hydroxylation and are involved in siderophore biosynthesis. This family includes L-ornithine 5-monooxygenase, which catalyzes the hydroxylation of L-ornithine at the N5 position, and L-lysine 6-monooxygenase, which catalyzes the hydroxylation of lysine at the N6 position (EC:1.14.13.59).


Pssm-ID: 433204 [Multi-domain]  Cd Length: 338  Bit Score: 48.74  E-value: 4.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505      81 YVPNSQFLEYLKMYANHFDllKHIQFKTKVCSVTKcSDSAVSGQWEVVTMHEEKQESAIF-DAVMVCTGflTNPYLPlDS 159
Cdd:pfam13434  91 FPSRREFNDYLQWAASHLP--NRLRFGQEVESVEP-DAERGEPLLRVRVRDADGEETTFLaRNLVLGTG--GEPYIP-EC 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     160 FPGinafKGQYFHSRQY--KHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSttgggWVISR-------------- 223
Cdd:pfam13434 165 ARG----GERVFHSSEYleRIDRLAAKKRIAVVGSGQSAAEIFRDLLRRGPAYELT-----WVTRSpnffplddspfvne 235
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     224 IFDSGYpwdmvfMTRFQnmlrnSLPTPivtwlMERKINNWLNHANYGLIpeDRTQLKEfvLNDELPGRIITGKVFIR--- 300
Cdd:pfam13434 236 IFSPEY------VDYFY-----SLPED-----TRRALLREQKGTNYDGI--DPSLIEE--IYRLLYEQRVDGDPRHRllp 295
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 399505     301 ----PSIKEVKENSV------IFNNTSKEEPIDIIVFATGYTF 333
Cdd:pfam13434 296 nrevQSAERVGDGGVeltlrdGEQGREETLETDVVVLATGYRR 338
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
5-212 7.47e-06

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 47.81  E-value: 7.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     5 VAIVGAGVSGL-ASIKCCLEeGLEPTCFERsDDLGGLWRFTEHVEegraslyksvvsnsckemscysDFP-FPEDypnyV 82
Cdd:COG0492   3 VVIIGAGPAGLtAAIYAARA-GLKTLVIEG-GEPGGQLATTKEIE----------------------NYPgFPEG----I 54
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505    83 PNSQFLEYLKMYANHFDllkhIQFK-TKVCSVTKcsdsaVSGQWEVVTmheEKQESAIFDAVMVCTGFltNP-YLPLdsf 160
Cdd:COG0492  55 SGPELAERLREQAERFG----AEILlEEVTSVDK-----DDGPFRVTT---DDGTEYEAKAVIIATGA--GPrKLGL--- 117
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 399505   161 PGINAFKGQ----------YFhsrqykhpdiFKDKRVLVIGMGNSGTDIAVEASHLAEKVFL 212
Cdd:COG0492 118 PGEEEFEGRgvsycatcdgFF----------FRGKDVVVVGGGDSALEEALYLTKFASKVTL 169
gltD PRK12810
glutamate synthase subunit beta; Reviewed
3-198 1.35e-05

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 47.47  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505      3 KRVAIVGAGVSGLAsikcCLEE----GLEPTCFERSDDLGGLWRFtehveeGRAS--LYKSVVSNSCKEMScysdfpfpe 76
Cdd:PRK12810 144 KKVAVVGSGPAGLA----AADQlaraGHKVTVFERADRIGGLLRY------GIPDfkLEKEVIDRRIELME--------- 204
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     77 dypnyvpnsqfleylKMyanhfdllkHIQFKTKVcsvtkcsdsavsgqwEV---VTMHEEKQEsaiFDAVMVCTGfLTNP 153
Cdd:PRK12810 205 ---------------AE---------GIEFRTNV---------------EVgkdITAEELLAE---YDAVFLGTG-AYKP 241
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 399505    154 -YLPldsFPGINAfKGQYF-----------HSRQYKHPDI-FKDKRVLVIGMGNSGTD 198
Cdd:PRK12810 242 rDLG---IPGRDL-DGVHFamdfliqntrrVLGDETEPFIsAKGKHVVVIGGGDTGMD 295
PRK12770 PRK12770
putative glutamate synthase subunit beta; Provisional
3-213 1.51e-05

putative glutamate synthase subunit beta; Provisional


Pssm-ID: 237197 [Multi-domain]  Cd Length: 352  Bit Score: 47.29  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505      3 KRVAIVGAGVSGLAS---IKCcleEGLEPTCFERSDDLGGLWRFT--------EHVEEGRASLYKSVVSNSCKEMSCYSD 71
Cdd:PRK12770  19 KKVAIIGAGPAGLAAagyLAC---LGYEVHVYDKLPEPGGLMLFGipefripiERVREGVKELEEAGVVFHTRTKVCCGE 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399505     72 FPFPEDypnyvpnsqfleylkmyANHFdllkhiqfktkVCSVTKCSDsavsgqwevvtMHEEkqesaiFDAVMVCTGF-- 149
Cdd:PRK12770  96 PLHEEE-----------------GDEF-----------VERIVSLEE-----------LVKK------YDAVLIATGTwk 130
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 399505    150 ---LTNP-------YLPLDSFPGINAFKgqYFHSRQYKHPDiFKDKRVLVIGMGNSGTDIAVEASHL-AEKVFLS 213
Cdd:PRK12770 131 srkLGIPgedlpgvYSALEYLFRIRAAK--LGYLPWEKVPP-VEGKKVVVVGAGLTAVDAALEAVLLgAEKVYLA 202
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
3-40 2.29e-05

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 46.75  E-value: 2.29e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 399505     3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGL 40
Cdd:COG1232   2 KRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGGL 39
PRK07233 PRK07233
hypothetical protein; Provisional
4-40 5.38e-05

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 45.65  E-value: 5.38e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 399505      4 RVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGL 40
Cdd:PRK07233   1 KIAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLGGL 37
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
1-39 1.69e-04

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 44.07  E-value: 1.69e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 399505     1 MAKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGG 39
Cdd:COG3349   2 MPPRVVVVGGGLAGLAAAVELAEAGFRVTLLEARPRLGG 40
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
7-42 2.67e-04

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 39.44  E-value: 2.67e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 399505       7 IVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWR 42
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNAY 36
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
3-43 4.41e-04

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 43.20  E-value: 4.41e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 399505      3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRF 43
Cdd:PRK12769 328 KRVAIIGAGPAGLACADVLARNGVAVTVYDRHPEIGGLLTF 368
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
3-36 2.86e-03

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 40.06  E-value: 2.86e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 399505     3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDD 36
Cdd:COG0771   5 KKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPA 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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