|
Name |
Accession |
Description |
Interval |
E-value |
| RNR_1b_NrdE |
TIGR04170 |
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, ... |
11-719 |
0e+00 |
|
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, the alpha subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron.
Pssm-ID: 211905 [Multi-domain] Cd Length: 698 Bit Score: 1115.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 11 YFKLNNEIN-RPVDGQIPLNKDKEALAAFFKENVEPNTRKFSSAEEKINFLMKEDFIETEFIEKYSMDFIEKLYAFLDEQ 89
Cdd:TIGR04170 2 YHALNNELNlYDDNGKIQFDKDKEALDAYFLEHVNQNTVFFHNLKEKLDYLVENNYYEEEVLDKYSFEFVIELFEHAYAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 90 HFQFKSFMAAYKFYSQYALKNNAGTEYLETYEDRVAFNALYFADGDEELALTLADEMIHQRYQPATPSFLNAGRKRRGEL 169
Cdd:TIGR04170 82 KFRFPSFMGAFKFYTSYALKTNDGKRYLERYEDRVCMVALTLANGDEELAKQLVDEMISQRYQPATPTFLNAGRARRGEL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 170 VSCFLVQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYDGAASGVVPVMKLFEDSFSYSNQLGQRQGAG 249
Cdd:TIGR04170 162 VSCFLLRVEDNMNSIGRAINSALQLSKRGGGVALNLSNLREAGAPIKGIENQSSGVIPVMKLLEDAFSYANQLGQRQGAG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 250 VVYLNVFHPDIEMFLSAKKENADEKIRVKTLSLGVIVPDKFYELTRNNEDMYLFSPYSVEREYGVPYSYVDITKEYDNLV 329
Cdd:TIGR04170 242 AVYLNAFHPDILRFLDTKKENADEKIRIKTLSLGVVIPDKFFELAKENKDMYLFSPYDVEREYGVPFDDIDITEKYDEMV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 330 ANPNIRKRKIKARDLENEISKLQQESGYPYIINIDTANKNNPIDGKIIMSNLCSEILQVQTPSVINGKQEYEVLGTDISC 409
Cdd:TIGR04170 322 ANPRIRKKKINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIIGRIKMSNLCSEILQVSEASLYNDYLEYDEIGHDISC 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 410 NLGSTNIVNLMESPDFGKSVRAMTRALTFVTDASEIDVVPTIQNGNRLSHTIGLGAMGLHTFFAKNHMEYGSEESLDFTD 489
Cdd:TIGR04170 402 NLGSLNIANVMDSPDFGRTVETAIRALTAVSDMSHIRNVPSIRKGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTN 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 490 IYFMLLNYWTLMESNQIAKERNQVFHNFEKSDYASGAYFDKYIEGNFTPKFDKVKEIFKDIQIPTAEDWAALRDAVKKDG 569
Cdd:TIGR04170 482 IYFMTVNYYSLRRSMEIARERGETFAGFEQSDYASGEYFDKYVSQEFAPKTEKVRELFEGIHIPTREDWAELKDDVMEYG 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 570 LYHQNRLAVAPNGSISYINDTSASIHPITRMIEERQEKKIGKIYYPAPYLANDTIPYYTSAYDMDMRKVIDVYATAQQHV 649
Cdd:TIGR04170 562 LYHQNRLAVAPTGSISYINHSTSSIHPIVSKIEIRKEGKIGRVYYPAPFLTNENLEYYQDAYDIDMEKIIDTYATATQHV 641
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 650 DQGMSLTLFMRSEipeglyewketpkQTTRDLNILRHYAFNKGIKSIYYIRTFTDDAEEIGSNQCESCVI 719
Cdd:TIGR04170 642 DQGLSLTLFFKDT-------------ATTRDLNRAQIYAWHKGIKTLYYIRLRQLALEGTEIEGCVSCAL 698
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
48-709 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 704.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 48 RKFSSAEEKINFLmKEDFIETEFIEkysmDFIEKLYAFLDEQHFQFKSFMAAYKFYSQYALKNNAGtEYLETYEDRVAFN 127
Cdd:COG0209 8 GQYKSFSEKIKYV-EEGLYDERLLE----EDLEELAAAIDPERDRFFSYNALKTLYDRYLLKDEDG-KPLETPQDLFMRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 128 ALYFADGD-----EELALTLADEMIHQRYQPATPSFLNAGRKRrGELVSCFLVQVTDDMNSIGRSINSALQLSRIGGGVG 202
Cdd:COG0209 82 AMGLAAAEkpedrEEWAKEFYDLLSSLRFLPATPTLFNAGTPR-GQLSSCFVLPVEDSLESIFDALKDAALLSKSGGGVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 203 ITLSNLREAGAPIKGYDGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIEMFLSAKKENADEKIRVKTLSL 282
Cdd:COG0209 161 FNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDERRRLHNFNI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 283 GVIVPDKFYELTRNNEDMYLFSPYSVEREYGVPYSyvDITKEYDNLVANPNIRKrKIKARDLENEISKLQQESGYPYIIN 362
Cdd:COG0209 241 SVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGE--EFEEAYEEYEADGRVYK-TIKARELWRKILESAWETGEPGILF 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 363 IDTANKNNPID--GKIIMSNLCSEILQVQTPSvingkqeyevlgTDISCNLGSTNIVNLME-----SPDFGKSVRAMTRA 435
Cdd:COG0209 318 KDTINRRNPLPhlGVIHSSNLCGEIPLLPYES------------EDASCNLGSINLAKFVKdgefdWEKLEETVRTAVRF 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 436 LTFVTDASEIdVVPTIQNGNRLSHTIGLGAMGLHTFFAKNHMEYGSEESLDFTDIYFMLLNYWTLMESNQIAKERNqVFH 515
Cdd:COG0209 386 LDNVIDINDY-PVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERG-AFP 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 516 NFEKSDYASGAYFdkyiegnftpkFDKVKEifkDIQIPTAEDWAALRDAVKKDGLYHQNRLAVAPNGSISYINDTSASIH 595
Cdd:COG0209 464 AFEGSKYAKGILP-----------FDKYLD---DLLIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIE 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 596 PITRMIEERQEKKIGKIYYPAPYLA------------------------------NDTIPYYTSAYDMDMRKVIDVYATA 645
Cdd:COG0209 530 PIFSLVYVRKVLDGGEFTVVNPYLVralkelglwdeelvekikedgsvqdidelpEELKELYVTAYEIDPEWHIDMQAAR 609
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1350107710 646 QQHVDQGMSLTLFMRSEIpeglyewketpkqTTRDLNILRHYAFNKGIKSIYYIRTFTDDAEEI 709
Cdd:COG0209 610 QKHVDQAISKTLNLPNDA-------------TVEDLAELYLLAWKLGLKGIYYYRDGSRTGQVL 660
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
170-699 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 606.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 170 VSCFLVQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYDGAASGVVPVMKLFEDSFSYSNQLGQRQGAG 249
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 250 VVYLNVFHPDIEMFLSAKKENADEKIRVKTLSLGVIVPDKFYELTRNNEDMYLFSPY---SVEREYGVPYSyvditKEYD 326
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPReapDLEDLYGEEFE-----KEYY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 327 NLVANPNIRKRKIKARDLENEISKLQQESGYPYIINIDTANKNNPI--DGKIIMSNLCSEILQVQTPSVIngkqeyevlg 404
Cdd:pfam02867 156 EREENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQkhLGTIKSSNLCTEIVQPTSPSEI---------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 405 tdISCNLGSTNIVNLMESP------DFGKSVRAMTRALTFVTDASeIDVVPTIQNGNRLSHTIGLGAMGLHTFFAKNHME 478
Cdd:pfam02867 226 --AVCNLASINLAKFVEFGgtfdfeKLREVVKLAVRALDNVIDIN-DYPVPEARRSNKRHRPIGLGVMGLADALAKLGIP 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 479 YGSEESLDFTDIYFMLLNYWTLMESNQIAKERNqVFHNFEKSDYASG-AYFDKYIEGNFTPKFDKvkeifkdiqipTAED 557
Cdd:pfam02867 303 YDSEEARDLNDKIFETMYYYALKASSELAKEKG-PFPGFEGSKYSKGiLQFDKYVKTDFAPKASK-----------TRED 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 558 WAALRDAVKKDGLYHQNRLAVAPNGSISYINDTSASIHPITRMIEERQEKKigkiyypapylaNDTIPYYTSAYDMDMRK 637
Cdd:pfam02867 371 WEELREDIKKYGLRNSQLTAIAPTGSISQIAGATESIEPIFSNVYSRKVLS------------EETKEYYKTAYDIDQKA 438
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1350107710 638 VIDVYATAQQHVDQGMSLTLFMRSEIpeglyewketpkqTTRDLNILRHYAFNKGIKSIYYI 699
Cdd:pfam02867 439 HIDMAAARQPFVDQSISKTLFLPNDA-------------TTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
120-701 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 566.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 120 YEDRVAFNALYFADGDEELALTLADEMIHQRYQPATPSFLNAGrKRRGELVSCFLVQVTDDMNSIGRSINSALQLSRIGG 199
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAG-TPRGQLSSCFLLTVDDSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 200 GVGITLSNLREAGAPIKGYDGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIEMFLSAKKENADEKIRVKT 279
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRARD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 280 LSLGVIVPDKFYELTRnnedmylfspysvereygvpysyvditkeydnlvanpnirkrkikaRDLENEISKLQQESGYPY 359
Cdd:cd01679 160 LFYGVWIPDLFMERVE----------------------------------------------RDLWRKILESQFETGYPY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 360 IINIDTANKNNP--IDGKIIMSNLCSEILQVQTPSvingkqeYEVLGTDISCNLGSTNIVNLMESPDFGKSVRAMTRALT 437
Cdd:cd01679 194 ILFKDTCNRKNPqkHLGTIKSSNLCTEILQPTSPS-------EDEPGEDAVCNLASINLGNFVTFEKLEEVVKLAVRALD 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 438 FVTDASEIDVVPtIQNGNRLSHTIGLGAMGLHTFFAKNHMEYGSEESLDFTDIYFMLLNYWTLMESNQIAKERNqvfhnf 517
Cdd:cd01679 267 NVIDLNYYPVPE-AKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG------ 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 518 eksdyasgayfdkyiegnftpkfdkvkeifkdiqiptaedwaalrdavkkdGLYHQNRLAVAPNGSISYINDTSASIHPI 597
Cdd:cd01679 340 ---------------------------------------------------GLRNSLLLAIAPTASISQILGATPSIEPI 368
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 598 TRMIEERQEKKiGKIYYPAPYLANDTIPY--YTSAYDMDMRKVIDVYATAQQHVDQGMSLTLFMRSEIpeglyewketpk 675
Cdd:cd01679 369 TSNIYVRRVLS-GEFPVVNPHLEKDLWEYglYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPA------------ 435
|
570 580
....*....|....*....|....*.
gi 1350107710 676 qTTRDLNILRHYAFNKGIKSIYYIRT 701
Cdd:cd01679 436 -TTRDLNSLYFYAWKKGLKTLYYLRT 460
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
71-717 |
2.27e-106 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 341.32 E-value: 2.27e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 71 IEKYSMDFIEKLYAFLDEQHFQFKSFMAAYKFYSQYALKNNAGTEYlETYEDRVAFNALYF-ADGDEELALTLADE---- 145
Cdd:PRK09209 133 LKRYSKEELIEAGKMIDPERDKLFTYIGLYLLADRYLATDSDRNVY-ELPQERWLTIALYLmQNEPRERRMQLVKEaywa 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 146 MIHQRYQPATPSFLNAGrKRRGELVSCFLVQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYDGAASGV 225
Cdd:PRK09209 212 LSNLYMTVATPTLANAG-KVGGQLSSCFIDTVDDSLQGIYDSNTDVARVSKHGGGVGAYLGKVRSRGSDIRGFKGVSSGV 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 226 VPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIEMFLSAKKENADEKIRVKTLSLGVIVPDKFYELTRNNEDMYLFSP 305
Cdd:PRK09209 291 IPWIKQLNNTAVSVDQLGQRKGAIAVYLDVWHKDIESFLDLRLNNGDERLRAHDVFTGVCIPDLFMEAVERRGDWYLFDP 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 306 YSVEREYGvpYSYVD----------ITKEYDNLVANPNIRKRKIKARDLENEISKLQQESGYPYIINIDTANKNNP--ID 373
Cdd:PRK09209 371 HEVKKVMG--WYLEDfydekkgdgsFREKYEECVADERLSRKTVKAIDIMKRIMVSQLETGNPFMFYRDEVNRMNPnkHE 448
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 374 GKIIMSNLCSEILQVQTPSVIngKQEYEVLGTDIS---------CNLGSTNIVNLMESPDFGKSVRAMTRALTFVTDASE 444
Cdd:PRK09209 449 GMIYSSNLCTEIMQNMSPTVM--IQEIISGGQIVItkqpgdfvvCNLSSINLGRAVTADVLERLIPIQVRMLDNVIDLNQ 526
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 445 IDvVPTIQNGNRLSHTIGLGAMGLHTFFAKNHMEYGSEESLDFTDIYFMLLNYWTLMESNQIAKERNQvFHNFEKSDYAS 524
Cdd:PRK09209 527 LP-VPQATITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQYADELYERINYLTIQASMELAKEKGA-YPVFKGSDWQT 604
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 525 GAYFDK--YiegnftpkfdkvkeifkdiqipTAEDWAALRDAVKKDGLYHQNRLAVAPNGSISYINDTSASIHPITRMiE 602
Cdd:PRK09209 605 GEYFERrgY----------------------NSPQWDELAAQVAENGVRNAYLMAVAPNMSTAQIAGSTASIDPIYSA-F 661
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 603 ERQEKKIGKIYYPAPYLANDTIPYYT-SAYDMDMRKVIDVYATAQQHVDQGMSLTLFMRSEIpeglyewketpkqTTRDL 681
Cdd:PRK09209 662 YYEEKKDYRRPVTAPDLSLDTWPYYEkGAYKVDQFWSIRQNAARQRHVDQSISFNFYVPSTI-------------RASEL 728
|
650 660 670
....*....|....*....|....*....|....*.
gi 1350107710 682 NILRHYAFNKGIKSIYYIRTFTDDAEEigsnqCESC 717
Cdd:PRK09209 729 LDLHMTAWKEGLKTTYYVRSTDIDIEE-----CEWC 759
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RNR_1b_NrdE |
TIGR04170 |
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, ... |
11-719 |
0e+00 |
|
ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Members of this family are NrdE, the alpha subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron.
Pssm-ID: 211905 [Multi-domain] Cd Length: 698 Bit Score: 1115.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 11 YFKLNNEIN-RPVDGQIPLNKDKEALAAFFKENVEPNTRKFSSAEEKINFLMKEDFIETEFIEKYSMDFIEKLYAFLDEQ 89
Cdd:TIGR04170 2 YHALNNELNlYDDNGKIQFDKDKEALDAYFLEHVNQNTVFFHNLKEKLDYLVENNYYEEEVLDKYSFEFVIELFEHAYAS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 90 HFQFKSFMAAYKFYSQYALKNNAGTEYLETYEDRVAFNALYFADGDEELALTLADEMIHQRYQPATPSFLNAGRKRRGEL 169
Cdd:TIGR04170 82 KFRFPSFMGAFKFYTSYALKTNDGKRYLERYEDRVCMVALTLANGDEELAKQLVDEMISQRYQPATPTFLNAGRARRGEL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 170 VSCFLVQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYDGAASGVVPVMKLFEDSFSYSNQLGQRQGAG 249
Cdd:TIGR04170 162 VSCFLLRVEDNMNSIGRAINSALQLSKRGGGVALNLSNLREAGAPIKGIENQSSGVIPVMKLLEDAFSYANQLGQRQGAG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 250 VVYLNVFHPDIEMFLSAKKENADEKIRVKTLSLGVIVPDKFYELTRNNEDMYLFSPYSVEREYGVPYSYVDITKEYDNLV 329
Cdd:TIGR04170 242 AVYLNAFHPDILRFLDTKKENADEKIRIKTLSLGVVIPDKFFELAKENKDMYLFSPYDVEREYGVPFDDIDITEKYDEMV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 330 ANPNIRKRKIKARDLENEISKLQQESGYPYIINIDTANKNNPIDGKIIMSNLCSEILQVQTPSVINGKQEYEVLGTDISC 409
Cdd:TIGR04170 322 ANPRIRKKKINARDFFQTLAEIQFESGYPYIMFEDTVNRANPIIGRIKMSNLCSEILQVSEASLYNDYLEYDEIGHDISC 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 410 NLGSTNIVNLMESPDFGKSVRAMTRALTFVTDASEIDVVPTIQNGNRLSHTIGLGAMGLHTFFAKNHMEYGSEESLDFTD 489
Cdd:TIGR04170 402 NLGSLNIANVMDSPDFGRTVETAIRALTAVSDMSHIRNVPSIRKGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTN 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 490 IYFMLLNYWTLMESNQIAKERNQVFHNFEKSDYASGAYFDKYIEGNFTPKFDKVKEIFKDIQIPTAEDWAALRDAVKKDG 569
Cdd:TIGR04170 482 IYFMTVNYYSLRRSMEIARERGETFAGFEQSDYASGEYFDKYVSQEFAPKTEKVRELFEGIHIPTREDWAELKDDVMEYG 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 570 LYHQNRLAVAPNGSISYINDTSASIHPITRMIEERQEKKIGKIYYPAPYLANDTIPYYTSAYDMDMRKVIDVYATAQQHV 649
Cdd:TIGR04170 562 LYHQNRLAVAPTGSISYINHSTSSIHPIVSKIEIRKEGKIGRVYYPAPFLTNENLEYYQDAYDIDMEKIIDTYATATQHV 641
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 650 DQGMSLTLFMRSEipeglyewketpkQTTRDLNILRHYAFNKGIKSIYYIRTFTDDAEEIGSNQCESCVI 719
Cdd:TIGR04170 642 DQGLSLTLFFKDT-------------ATTRDLNRAQIYAWHKGIKTLYYIRLRQLALEGTEIEGCVSCAL 698
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
48-709 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 704.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 48 RKFSSAEEKINFLmKEDFIETEFIEkysmDFIEKLYAFLDEQHFQFKSFMAAYKFYSQYALKNNAGtEYLETYEDRVAFN 127
Cdd:COG0209 8 GQYKSFSEKIKYV-EEGLYDERLLE----EDLEELAAAIDPERDRFFSYNALKTLYDRYLLKDEDG-KPLETPQDLFMRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 128 ALYFADGD-----EELALTLADEMIHQRYQPATPSFLNAGRKRrGELVSCFLVQVTDDMNSIGRSINSALQLSRIGGGVG 202
Cdd:COG0209 82 AMGLAAAEkpedrEEWAKEFYDLLSSLRFLPATPTLFNAGTPR-GQLSSCFVLPVEDSLESIFDALKDAALLSKSGGGVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 203 ITLSNLREAGAPIKGYDGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIEMFLSAKKENADEKIRVKTLSL 282
Cdd:COG0209 161 FNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDERRRLHNFNI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 283 GVIVPDKFYELTRNNEDMYLFSPYSVEREYGVPYSyvDITKEYDNLVANPNIRKrKIKARDLENEISKLQQESGYPYIIN 362
Cdd:COG0209 241 SVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGE--EFEEAYEEYEADGRVYK-TIKARELWRKILESAWETGEPGILF 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 363 IDTANKNNPID--GKIIMSNLCSEILQVQTPSvingkqeyevlgTDISCNLGSTNIVNLME-----SPDFGKSVRAMTRA 435
Cdd:COG0209 318 KDTINRRNPLPhlGVIHSSNLCGEIPLLPYES------------EDASCNLGSINLAKFVKdgefdWEKLEETVRTAVRF 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 436 LTFVTDASEIdVVPTIQNGNRLSHTIGLGAMGLHTFFAKNHMEYGSEESLDFTDIYFMLLNYWTLMESNQIAKERNqVFH 515
Cdd:COG0209 386 LDNVIDINDY-PVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERG-AFP 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 516 NFEKSDYASGAYFdkyiegnftpkFDKVKEifkDIQIPTAEDWAALRDAVKKDGLYHQNRLAVAPNGSISYINDTSASIH 595
Cdd:COG0209 464 AFEGSKYAKGILP-----------FDKYLD---DLLIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIE 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 596 PITRMIEERQEKKIGKIYYPAPYLA------------------------------NDTIPYYTSAYDMDMRKVIDVYATA 645
Cdd:COG0209 530 PIFSLVYVRKVLDGGEFTVVNPYLVralkelglwdeelvekikedgsvqdidelpEELKELYVTAYEIDPEWHIDMQAAR 609
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1350107710 646 QQHVDQGMSLTLFMRSEIpeglyewketpkqTTRDLNILRHYAFNKGIKSIYYIRTFTDDAEEI 709
Cdd:COG0209 610 QKHVDQAISKTLNLPNDA-------------TVEDLAELYLLAWKLGLKGIYYYRDGSRTGQVL 660
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
170-699 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 606.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 170 VSCFLVQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYDGAASGVVPVMKLFEDSFSYSNQLGQRQGAG 249
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 250 VVYLNVFHPDIEMFLSAKKENADEKIRVKTLSLGVIVPDKFYELTRNNEDMYLFSPY---SVEREYGVPYSyvditKEYD 326
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPReapDLEDLYGEEFE-----KEYY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 327 NLVANPNIRKRKIKARDLENEISKLQQESGYPYIINIDTANKNNPI--DGKIIMSNLCSEILQVQTPSVIngkqeyevlg 404
Cdd:pfam02867 156 EREENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQkhLGTIKSSNLCTEIVQPTSPSEI---------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 405 tdISCNLGSTNIVNLMESP------DFGKSVRAMTRALTFVTDASeIDVVPTIQNGNRLSHTIGLGAMGLHTFFAKNHME 478
Cdd:pfam02867 226 --AVCNLASINLAKFVEFGgtfdfeKLREVVKLAVRALDNVIDIN-DYPVPEARRSNKRHRPIGLGVMGLADALAKLGIP 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 479 YGSEESLDFTDIYFMLLNYWTLMESNQIAKERNqVFHNFEKSDYASG-AYFDKYIEGNFTPKFDKvkeifkdiqipTAED 557
Cdd:pfam02867 303 YDSEEARDLNDKIFETMYYYALKASSELAKEKG-PFPGFEGSKYSKGiLQFDKYVKTDFAPKASK-----------TRED 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 558 WAALRDAVKKDGLYHQNRLAVAPNGSISYINDTSASIHPITRMIEERQEKKigkiyypapylaNDTIPYYTSAYDMDMRK 637
Cdd:pfam02867 371 WEELREDIKKYGLRNSQLTAIAPTGSISQIAGATESIEPIFSNVYSRKVLS------------EETKEYYKTAYDIDQKA 438
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1350107710 638 VIDVYATAQQHVDQGMSLTLFMRSEIpeglyewketpkqTTRDLNILRHYAFNKGIKSIYYI 699
Cdd:pfam02867 439 HIDMAAARQPFVDQSISKTLFLPNDA-------------TTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
120-701 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 566.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 120 YEDRVAFNALYFADGDEELALTLADEMIHQRYQPATPSFLNAGrKRRGELVSCFLVQVTDDMNSIGRSINSALQLSRIGG 199
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAG-TPRGQLSSCFLLTVDDSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 200 GVGITLSNLREAGAPIKGYDGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIEMFLSAKKENADEKIRVKT 279
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRARD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 280 LSLGVIVPDKFYELTRnnedmylfspysvereygvpysyvditkeydnlvanpnirkrkikaRDLENEISKLQQESGYPY 359
Cdd:cd01679 160 LFYGVWIPDLFMERVE----------------------------------------------RDLWRKILESQFETGYPY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 360 IINIDTANKNNP--IDGKIIMSNLCSEILQVQTPSvingkqeYEVLGTDISCNLGSTNIVNLMESPDFGKSVRAMTRALT 437
Cdd:cd01679 194 ILFKDTCNRKNPqkHLGTIKSSNLCTEILQPTSPS-------EDEPGEDAVCNLASINLGNFVTFEKLEEVVKLAVRALD 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 438 FVTDASEIDVVPtIQNGNRLSHTIGLGAMGLHTFFAKNHMEYGSEESLDFTDIYFMLLNYWTLMESNQIAKERNqvfhnf 517
Cdd:cd01679 267 NVIDLNYYPVPE-AKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG------ 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 518 eksdyasgayfdkyiegnftpkfdkvkeifkdiqiptaedwaalrdavkkdGLYHQNRLAVAPNGSISYINDTSASIHPI 597
Cdd:cd01679 340 ---------------------------------------------------GLRNSLLLAIAPTASISQILGATPSIEPI 368
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 598 TRMIEERQEKKiGKIYYPAPYLANDTIPY--YTSAYDMDMRKVIDVYATAQQHVDQGMSLTLFMRSEIpeglyewketpk 675
Cdd:cd01679 369 TSNIYVRRVLS-GEFPVVNPHLEKDLWEYglYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPA------------ 435
|
570 580
....*....|....*....|....*.
gi 1350107710 676 qTTRDLNILRHYAFNKGIKSIYYIRT 701
Cdd:cd01679 436 -TTRDLNSLYFYAWKKGLKTLYYLRT 460
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
96-701 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 541.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 96 FMAAYKFYSQYALKNNAGTEYLET---YEDRVAFNALYFADGDEELALTLADEMIHQRYQPATPSFLNAG-RKRRGELVS 171
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAATGAIYESpqeAYMRVAMGLASLEPKDTRLADAIRFYDLLSRLKISPATPTLFNaGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 172 CFLVQVTDD-MNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYDGAASGVVPVMKLFEDSFSYSNQLGQRQGAGV 250
Cdd:TIGR02506 81 CFLLDVTDDtLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGGKRPGAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 251 VYLNVFHPDIEMFLSAKKENADEKIRVKTLSLGVIVPDKFYELTRNNEDMYLFSPYSVEREYGVPYSyvDITKEYDNLVA 330
Cdd:TIGR02506 161 VYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGE--EFEEEYERLEK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 331 NPNIRK--RKIKARDLENEISKLQQESGYPYIINIDTANKNNPID---GKIIMSNLCSEILQVQTPSVIngkqeyevlGT 405
Cdd:TIGR02506 239 DVEARKkiRKVSARDLMKDILRTRVETGRPYILFKDAVNKHNPFKtggGAIKMSNLCTEITQPTDDSHK---------GE 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 406 DISCNLGSTNIVNLMESPDFG-----KSVRAMTRALTFVTDASEIDVVPTIQNGNRLsHTIGLGAMGLHTFFAKNHMEYG 480
Cdd:TIGR02506 310 TAVCNLASVNLANFVMEDKFDfseleDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRR-RSIGIGVMGLHDVLAKLGLPYD 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 481 SEESLDFTDIYFMLLNYWTLMESNQIAKERNqVFHNFEKSDYASGAYFDKYIEGNFTPKFDkvkeifkdiQIPTAEDWAA 560
Cdd:TIGR02506 389 SEEARDLNDRIFEAIYYYAIKASAELAKEKG-PFPGFSGSKYAKGWLHPDTWEKTIDPKTS---------MAPTEEDWEA 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 561 LRDAVKKDGLYHQNRLAVAPNGSISYINDTSASIHPITRMI----------------------------EERQEKKIGKI 612
Cdd:TIGR02506 459 LRERIKEYGLRNSQLTALMPTASSSQLTGVTESIEPVFSNIftkktlsgeflipnkylmkeleelglwdADRRGDIVENV 538
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 613 YYPAPYLANDTIPYYTS--AYDMDMRKVIDVYATAQQHVDQGMSLTLFMrseipeglyewkeTPKQTTRDLNILRHYAFN 690
Cdd:TIGR02506 539 GSPQPIAAIPETLKYKYktAYELDQEALIDMAADRQKFVDQSISLNLFL-------------TEEVTAKDLLKLLLLAWK 605
|
650
....*....|.
gi 1350107710 691 KGIKSIYYIRT 701
Cdd:TIGR02506 606 KGLKTMYYCRS 616
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
71-717 |
2.27e-106 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 341.32 E-value: 2.27e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 71 IEKYSMDFIEKLYAFLDEQHFQFKSFMAAYKFYSQYALKNNAGTEYlETYEDRVAFNALYF-ADGDEELALTLADE---- 145
Cdd:PRK09209 133 LKRYSKEELIEAGKMIDPERDKLFTYIGLYLLADRYLATDSDRNVY-ELPQERWLTIALYLmQNEPRERRMQLVKEaywa 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 146 MIHQRYQPATPSFLNAGrKRRGELVSCFLVQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYDGAASGV 225
Cdd:PRK09209 212 LSNLYMTVATPTLANAG-KVGGQLSSCFIDTVDDSLQGIYDSNTDVARVSKHGGGVGAYLGKVRSRGSDIRGFKGVSSGV 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 226 VPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIEMFLSAKKENADEKIRVKTLSLGVIVPDKFYELTRNNEDMYLFSP 305
Cdd:PRK09209 291 IPWIKQLNNTAVSVDQLGQRKGAIAVYLDVWHKDIESFLDLRLNNGDERLRAHDVFTGVCIPDLFMEAVERRGDWYLFDP 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 306 YSVEREYGvpYSYVD----------ITKEYDNLVANPNIRKRKIKARDLENEISKLQQESGYPYIINIDTANKNNP--ID 373
Cdd:PRK09209 371 HEVKKVMG--WYLEDfydekkgdgsFREKYEECVADERLSRKTVKAIDIMKRIMVSQLETGNPFMFYRDEVNRMNPnkHE 448
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 374 GKIIMSNLCSEILQVQTPSVIngKQEYEVLGTDIS---------CNLGSTNIVNLMESPDFGKSVRAMTRALTFVTDASE 444
Cdd:PRK09209 449 GMIYSSNLCTEIMQNMSPTVM--IQEIISGGQIVItkqpgdfvvCNLSSINLGRAVTADVLERLIPIQVRMLDNVIDLNQ 526
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 445 IDvVPTIQNGNRLSHTIGLGAMGLHTFFAKNHMEYGSEESLDFTDIYFMLLNYWTLMESNQIAKERNQvFHNFEKSDYAS 524
Cdd:PRK09209 527 LP-VPQATITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQYADELYERINYLTIQASMELAKEKGA-YPVFKGSDWQT 604
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 525 GAYFDK--YiegnftpkfdkvkeifkdiqipTAEDWAALRDAVKKDGLYHQNRLAVAPNGSISYINDTSASIHPITRMiE 602
Cdd:PRK09209 605 GEYFERrgY----------------------NSPQWDELAAQVAENGVRNAYLMAVAPNMSTAQIAGSTASIDPIYSA-F 661
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 603 ERQEKKIGKIYYPAPYLANDTIPYYT-SAYDMDMRKVIDVYATAQQHVDQGMSLTLFMRSEIpeglyewketpkqTTRDL 681
Cdd:PRK09209 662 YYEEKKDYRRPVTAPDLSLDTWPYYEkGAYKVDQFWSIRQNAARQRHVDQSISFNFYVPSTI-------------RASEL 728
|
650 660 670
....*....|....*....|....*....|....*.
gi 1350107710 682 NILRHYAFNKGIKSIYYIRTFTDDAEEigsnqCESC 717
Cdd:PRK09209 729 LDLHMTAWKEGLKTTYYVRSTDIDIEE-----CEWC 759
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
48-717 |
9.18e-101 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 328.63 E-value: 9.18e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 48 RKFSSAEEKINFLMKEDFIETEFIEKYSMDFIEKLYAFLDEQHFQFKSFMAAYKFYSQYALKNNAGtEYLETYEDRVAFN 127
Cdd:PRK12364 190 LGIHSFYDKIKYLTEEGLYGSYILEHYSREEIEEAAGFIDPERDKLFTYSGLDLLLKRYVIRTHSH-EPLESPQEMFLGI 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 128 ALYFADGDEELALTLA----DEMIHQRYQPATPSFLNAgRKRRGELVSCFLVQVTDDMNSIGRSINSALQLSRIGGGVGI 203
Cdd:PRK12364 269 ALHLAMPEKQDRMGWVkrfyDMLSKLKVTMATPTLSNA-RKPFHQLSSCFIDTVPDSLDGIYRSIDNFAQVSKFGGGMGL 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 204 TLSNLREAGAPIKGYDGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIEMFLSAKKENADEKIRVKTLSLG 283
Cdd:PRK12364 348 YFGKVRAVGSNIRGFQGVAGGVIRWIKLANDTAVAVDQLGMRQGAVAVYLDVWHKDIPEFLQLRTNNGDDRMKAHDVFPA 427
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 284 VIVPDKFYELTRN--NEDMYLFSPYSVEREYGvpYSYVDI-----TKEYDNLVANPNIRKRKIKARDLENEISKLQQESG 356
Cdd:PRK12364 428 VCYPDLFWKMVRDdiNQSWYLFCPHEILTVKG--YALEDYygeewEKRYLDCVNDARISKRSIPIKDLVRLILKSAVETG 505
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 357 YPYIINIDTANKNNPI--DGKIIMSNLCSEILQVQTPSVINGKQEYEVLGTDI-----------SCNLGSTNIVNL-MES 422
Cdd:PRK12364 506 TPFTFNRDTVNRANPNkhKGMIYCSNLCTEIAQNMSAIETVSTEIETEDGDTVvvtttrpgdfvVCNLASLSLGNIdLED 585
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 423 PDFGKS-VRAMTRALTFVtdaseIDV----VPTIQNGNRLSHTIGLGAMGLHTFFAKNHMEYGSEESLDFTDIYFMLLNY 497
Cdd:PRK12364 586 EEELEEvVRTVVRALDNV-----IDLnfypVPYAQITNKRYRSIGLGVSGYHHALAKNGIRWESEEHLEFADRVFERINY 660
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 498 WTLMESNQIAKERNQvFHNFEKSDYASGAYFDK--YiegnftpkfdkvkeifkdiqipTAEDWAALRDAVKKDGLYHQNR 575
Cdd:PRK12364 661 AAIKASMEIAKEKGA-YGYFEGSDWQTGAYFRKrgY----------------------TSEEWQRLAREVAENGMRNAYL 717
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 576 LAVAPNGSISYINDTSASIHPI-TRMIEErqEKKIGKIYYPAPYLANDTIPYYTSAYDMDMRKVIDVYATAQQHVDQGMS 654
Cdd:PRK12364 718 LAVAPTSSTSIIAGTTAGVDPVmKRYFLE--EKKGALMPRVAPELSDKTFWLYKNAHLIDQKWSIRAAGVRQRHIDQAQS 795
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1350107710 655 LTLFMRSEIpeglyewketpkqTTRDLNILRHYAFNKGIKSIYYIRTFTDDAEEigsnqCESC 717
Cdd:PRK12364 796 VNLYITNEF-------------TMRQVLDLYLLAWEEGVKTIYYVRSKSLEVEE-----CESC 840
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
57-717 |
3.74e-84 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 282.08 E-value: 3.74e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 57 INFLMKEDFIETEFIEKYSMDFIEKLYAFLD-EQHFQFkSFMAAYKFYSQYALKNNAGtEYLETYEDRVAFNALYFA--D 133
Cdd:PRK07088 121 VKKLVEEKLYGEYLLQNYSKEEIKELEKYIKpERDFLF-NYEGLKLLADRYLVKGFNR-EILELPQERFMGIAMHLAipE 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 134 GDE---ELALTLADEMIHQRYQPATPSFLNAgRKRRGELVSCFLVQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLRE 210
Cdd:PRK07088 199 GKEkrvYYAKKFYDLLSELKATVATPTLSNA-GTPFYQLSSCFISVVDDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRA 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 211 AGAPIKGYDGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIEMFLSAKKENADEKIRVKTLSLGVIVPDKF 290
Cdd:PRK07088 278 LNSEIRGFKNASGGVIPWIKLYNDTAIAVDQLGKRKGGAAITLDIWHKDIPEFLDLKTNNGDDRRKAHDIFPGVSYPDLF 357
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 291 YELTRNNEDMYLFSPYSVEREYGvpYSYVDI---------TKEYDNLVANPNIRKRKIKARDLENEISKLQQESGYPYII 361
Cdd:PRK07088 358 MKRLEKRENWSLFDPHEIKKVKG--YSLEDYydeedrkefTKKYLECEEDTNIPRRTVPVLDIMKKIMKSAVETGTPFIF 435
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 362 NIDTANKNNP--IDGKIIMSNLCSEILQVQTPS------VINGKQEYEVL-----GTDISCNLGSTNIVNLmESPDFGKS 428
Cdd:PRK07088 436 FRDTVNKANPnkHKGMIYSSNLCHEIAQNMSESelleeeIIDENGYYEVVqkikaGDMVTCNLNSIVLGNV-DDEELEEV 514
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 429 VRAMTRALTFVTDASEIDvVPTIQNGNRLSHTIGLGAMGLHTFFAKNHMEYGSEESLDFTDIYFMLLNYWTLMESNQIAK 508
Cdd:PRK07088 515 IPTQIRMLDNVISLNYYP-VPEAEITSDKYRAIGLGTSGYHHMLANNKIRWESDEHIKFADKIYEEIAYYAIKASMELAK 593
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 509 ERNQvFHNFEKSDYASGAYFDK--YiegnftpkfdkvkeifkdiqipTAEDWAALRDAVKKDGLYHQNRLAVAPNGSISY 586
Cdd:PRK07088 594 EKGS-YPAFKGSEWETGKYFERrgY----------------------NSERWKKLKEEIKKYGMRNGYITAVAPTGSTSN 650
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 587 INDTSASIHPITR--MIEERQEKKIGKIyypAPYLANDTIPYYTSAYDMDMRKVIDVYATAQQHVDQGMSLTLFMrseip 664
Cdd:PRK07088 651 IANTTAGIDPVFKrfFMEEKKGSFTPKT---APDLNEENFWYYKEAHTIDQQWSIKACGVRQRHIDQAQSFNLYI----- 722
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|...
gi 1350107710 665 eglyewkeTPKQTTRDLNILRHYAFNKGIKSIYYIRTftddaEEIGSNQCESC 717
Cdd:PRK07088 723 --------TPEYKAKQILNLYIEAWKQGVKTIYYVRN-----KSLEMDECTSC 762
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
72-717 |
1.06e-67 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 237.70 E-value: 1.06e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 72 EKYSMDFIEklyAFLD-EQHFQFkSFMAAYKFYSQYALKNNAGtEYLETYEDRVAFNALYFADGD---EELALTLADEMI 147
Cdd:PRK08447 118 EKYDLDDLN---AYIKpERDLQF-NYLGIKTLYDRYLIKDRNN-NPIELPQHMFMAIAMFLAQNEldpQKWAKKFYDVIS 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 148 HQRYQPATPSFLNAgRKRRGELVSCFLVQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYDGAASGVVP 227
Cdd:PRK08447 193 KFEVMLATPTLSNA-RTTRHQLSSCYIGSTPDNIEGIFDSYKEMALLSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIP 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 228 VMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIEMFLSAKKENADEKIRVKTLSLGVIVPDKFYELTRNNEDMYLFSPYS 307
Cdd:PRK08447 272 FLKITNDIAIAVDQLGTRKGAIAVYLEPWHMDISDFIDLRKNSGEERRRAHDLFPALWINDLFMKRVEEDAMWTLFDPYE 351
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 308 VE---REYGVPYSyvditKEYDNLVANPNIRKRKIKARDLENEISKLQQESGYPYIINIDTANKNNPID--GKIIMSNLC 382
Cdd:PRK08447 352 CKdltELYGEEFE-----KRYLEYEKDEKIIKEYINAKELWKKILTNYFETGLPFLCFKDNANRANPNAhaGIIRSSNLC 426
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 383 SEILQVQTPS---------------------------------------VINGKQEYEVL-----GTDISCNLGSTNIVN 418
Cdd:PRK08447 427 TEIFQNTAPNhykikiefedgsieffeeeelvtvdsgitkkakkitsldSLKGKKIYIVEkekkdGKTAVCNLASINLSK 506
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 419 LMESPDFGKSVRAMTRALTFVTDaseIDVVP--TIQNGNRLSHTIGLGAMGLHTFFAKNHMEYGSEESLDFTDIYFMLLN 496
Cdd:PRK08447 507 INTKEDIERVVPIAIRMLDNVID---LNFYPnrKVKATNLKSRAIGLGVMGEAQMLAEHKIAWGSKEHLEKIDEIMEQIS 583
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 497 YWTLMESNQIAKERNqVFHNFEKSDYASGAyFDKYIEGNFTPKFDKVKEIFKdiqipTAEDWAALRDAVKKDGLYHQNRL 576
Cdd:PRK08447 584 YNAIDASSNLALEKG-VYPDFEGSNWSKGI-FPIDKANEEAKKLVERGGLFD-----SACDWEGLREKVKKDGMRNGYLM 656
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 577 AVAPNGSISYINDTSASIHPITRMiEERQEKKIGKIYYPAPYLANDTIPYYTSAYDMDMRKVIDVYATAQQHVDQGMSLT 656
Cdd:PRK08447 657 AIAPTSSISILVGTTQTIEPVYKR-KWFEENLSGLIPVVVPNLSPETWQYYTPAYDLDQKDLIKAAAVRQKWIDQGQSLN 735
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1350107710 657 LFMRSEIPEGLYewketpkqttrdLNILRHYAFNKGIKSIYYIRTFTDDAEEIG----SNQCESC 717
Cdd:PRK08447 736 IFLSLDKASGKY------------LNEIYTLAWKLGLKSTYYLRSESPESEEVSvadrSIECEGC 788
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
106-664 |
3.30e-66 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 229.13 E-value: 3.30e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 106 YALKNNAGTeYLETYED---RVAFN-----ALYFADGDEELALTLADEMIHQRYQPATPSFLNAGRKRRGELVSCFLVQV 177
Cdd:TIGR02504 6 YLLKDEDGN-IIESPEDlfrRVARAlaaaeDKYNSPVWKQWYERFYDLMVNLGFIPNSPTLMNAGGTRLGQLSACFVLPV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 178 TDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYDGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFH 257
Cdd:TIGR02504 85 EDSMEDIFEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGGTRRGAQMGILDVWH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 258 PDIEMFLSAKKENadEKIRVKTLSLGviVPDKFYELTRNNEDMYLFSPYsvereygvpysyvdiTKEYdnlvanpnirkR 337
Cdd:TIGR02504 165 PDIEEFIEAKAKE--GKLQNFNISVG--VTDEFMEAVENDEEYELRNPR---------------TGEY-----------K 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 338 KIKARDLENEISKLQQESGYPYIINIDTANK--NNPIDGKIIMSNLCSEILQVqtpsvingkqEYEvlgtdiSCNLGSTN 415
Cdd:TIGR02504 215 EVDARELWDKIVESAWKSAEPGVLFIDTINKwhTCPYGGRINATNPCGEQPLL----------PYE------SCNLGSIN 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 416 IVNLMESP----------DFGKSVRAMTRALTFVTDASeidVVPTIQNG--NRLSHTIGLGAMGLHTFFAKNHMEYGSEE 483
Cdd:TIGR02504 279 LAKFVKNDfgdeasfdfeRLREVVRLATRFLDNVIDIN---VFPLPEIAenTKKTRRIGLGIMGLADLLIKLGIPYDSEE 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 484 SLDFTDIYFMLLNYWTLMESNQIAKERnqvfhnfeksdyasgayfdkyieGNFtPKFDKVKEI---FKDIQIPTAEDWaA 560
Cdd:TIGR02504 356 ARELAEEVMEFIADAAYRASAELAKER-----------------------GAF-PLYDASKYPmgrAMGARIPSALPA-E 410
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 561 LRDAVKKDGLYHQNRLAVAPNGSISYINDTSASIHPI------------TRMIE----------ERQEKKIGKIYYPAPY 618
Cdd:TIGR02504 411 IREAIRKYGIRNAQLTTIAPTGTISLIAGTSSGIEPVfalvyfrnvtvgGELLEvnplvelalrELGYYSDEIVKYVDEK 490
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|...
gi 1350107710 619 LANDTIP-------YYTSAYDMDMRKVIDVYATAQQHVDQGMSLTLFMRSEIP 664
Cdd:TIGR02504 491 GTVEGAPgpeelpkVFVTAMDISPEDHVLMQAAIQPWVDSSISKTINMPSDAT 543
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
142-665 |
1.22e-65 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 224.42 E-value: 1.22e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 142 LADEMIHQRYQPATPSFLNAGRKRRGELVSCFLVQVTDD-MNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYDG 220
Cdd:cd02888 4 FFYLLLSQGFIPNSPTLMNAGTGELGQLSACFVLPVEDDsIEGIFDALKEAALIFKRGGGVGYNFSRLRPKGDIVKSTGG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 221 AASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIEMFLSAKKENADEKiRVKTLSLGVIVPDKFYELTRNNEDM 300
Cdd:cd02888 84 VASGPVSFMRVFDAATGVIKQGGTRRGANMGVLDVDHPDIEEFIDAKMKEEKTV-VLQNFNISVAVTDAFMEAVENDEPW 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 301 YLfspysVEREYGVPysyvdiTKEYdnlvanpnirkRKIKARDLENEISKLQQESGYPYIINIDTANKNNPID--GKIIM 378
Cdd:cd02888 163 EL-----RNPREPDT------GKVY-----------RTVPARELWDKIVEAAWDSADPGVLFIDTINRWNPLPglGRINA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 379 SNLCSEilQVQTPsvingkqeYEvlgtdiSCNLGSTNIVNLMESPD---------FGKSVRAMTRALTFVTDASeidVVP 449
Cdd:cd02888 221 TNPCGE--QPLLP--------YE------SCNLGSINLSKFVKNPFggasfdferLREAVRLAVRFLDNVIDVN---RYP 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 450 TIQNG--NRLSHTIGLGAMGLHTFFAKNHMEYGSEESLDFTDIYFMLLNYWTLMESNQIAKERnqvfhnfeksdyasgay 527
Cdd:cd02888 282 LPEIAeeTKATRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKER----------------- 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 528 fdkyieGNFtPKFDKVKEIFKDIQIPTAEDWAALRDAVKKDGLYHQNRLAVAPNGSISYINDTSASIHPItrmieerqek 607
Cdd:cd02888 345 ------GPF-PLFDASRYLMLKVIVNAKELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSSGIEPI---------- 407
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 1350107710 608 kigkiyypapylandtipyYTSAYDMDMRkvidvyATAQQHVDQGMSLTLFMRSEIPE 665
Cdd:cd02888 408 -------------------FSPEDHVRMQ------AALQPWVDGAISKTINLPNDATV 440
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
116-701 |
2.95e-63 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 221.76 E-value: 2.95e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 116 YL---ETYEDRVAFNALYFADGDEELALTLADEMIHQRYQPATPSFLNAGrKRRGELVSCFLVQVTDDMNSIGRSINSAL 192
Cdd:PRK09102 33 YLlegESYQDLFARIAEAYADIDPEHAQRFYDYMSRGWFMPATPVLSNGG-TDRGLPISCFLNYVEDSLEGIVNTWNENV 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 193 QLSRIGGGVGITLSNLREAGAPIKGyDGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIEMFLSAKKENAD 272
Cdd:PRK09102 112 WLAKRGGGIGSYWGNVRSIGEPIRN-NGKSSGIIPFIKVMDSLTLAISQGSLRRGSFAVYLDIEHPEIEEFLDIRKPTGD 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 273 EKIRVKTLSLGVIVPDKFYELTRNNEDMYLFSPysvereygvpysyvditkeYDNLVAnpnirkRKIKARDLENEISKLQ 352
Cdd:PRK09102 191 PNRKALNLHHGVCVTDEFMEAVEDGDEWDLISP-------------------KDKSVI------RTVKARDLWAKILETR 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 353 QESGYPYIINIDTANKNNP-----IDGKIIMSNLCSEILqVQTPSVINGKQEYEVlgtdisCNLGSTNIVNLMESPDFGK 427
Cdd:PRK09102 246 IETGEPYLLFIDNVNRALPevykdLGLKVKASNLCSEIT-LPTGIDHLGEDRTAV------CCLSSLNLEYYDEWKDTDA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 428 SVRAMTRALTFV-TDAseIDVVP-TIQNGNRL---SHTIGLGAMGLHTFFAKNHMEYGSEESLDFTDIYFMLLNYWTLME 502
Cdd:PRK09102 319 FIEDLMRFLDNVlQDF--IDKAPdEMERAKYSamrERSVGLGVMGFHSYLQSKMIPFESVMAKQWNKKIFKHIREQADKA 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 503 SNQIAKERnqvfhnfeksdyasGAyfdkyiegnftpkfdkvkeifkdiqIPTAEDWAALRDAVKKdglyhqnrLAVAPNG 582
Cdd:PRK09102 397 SKELAKEK--------------GE-------------------------CPDAAGYGVMRRFSTK--------MAIAPTA 429
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 583 SISYI-NDTSASIHPITRMIEERQEKKiGKIYYPAPYLA---------NDTI----------------------PYYTSA 630
Cdd:PRK09102 430 SISIIlGNTSPGIEPIAANYYTHKTLK-GSFTVKNKYLEklleekgkdTDEVwssiltnegsvqhldflseeekDVFKTA 508
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1350107710 631 YDMDMRKVIDVYATAQQHVDQGMSLTLFMRSEIPeglyewketpkqtTRDLNILRHYAFNKGIKSIYYIRT 701
Cdd:PRK09102 509 FEIDQRWIIELAADRQKYIDQAQSLNLFLPANVP-------------KRDLNKLHFEAWKKGVKSLYYQRS 566
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
71-701 |
1.17e-62 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 226.75 E-value: 1.17e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 71 IEKYSMDFIEKLYAFLDEQHFqfkSFMAAYKFYSQYAlkNNAGTEYLET---YEDRVAFN-ALYFADGDEELALTLADEM 146
Cdd:PRK12365 358 LKHYDLDALAEALDLSRDLQF---SYMGVQNLYDRYF--NHHEGRRLETpqiFWMRVSMGlALNEGQDKTSWAITFYNLL 432
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 147 IHQRYQPATPSFLNAGrKRRGELVSCFLVQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYDGAASGVV 226
Cdd:PRK12365 433 STFRYTPATPTLFNSG-MRHSQLSSCYLSTVQDDLVHIYKVISDNAMLSKWAGGIGNDWTAVRATGALIKGTNGKSQGVI 511
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 227 PVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIEMFLSAKKENADEKIRVKTLSLGVIVPDKFYELTRNNEDMYLFSPY 306
Cdd:PRK12365 512 PFIKVANDTAVAVNQGGKRKGAVCVYLEVWHLDYEDFLELRKNTGDERRRTHDINTASWIPDLFFKRLQQKGTWTLFSPD 591
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 307 SV---EREYGVPYSyvDITKEYDNLVANPNIR-KRKIKARDLENEISKLQQESGYPYIINIDTANKNNPID--GKIIMSN 380
Cdd:PRK12365 592 DVpglHEAYGEEFE--KLYEEYERKVDTGEIRlYKKVEAEDLWRKMLSMLYETGHPWMTFKDPSNIRSAQDhkGVVRCSN 669
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 381 LCSEILqvqtpsvINGKQEYEVLgtdisCNLGSTNIVNLMESPD-----FGKSVRAMTRALTFVTDaseIDVVPTIQNGN 455
Cdd:PRK12365 670 LCTEIL-------LNCSETETAV-----CNLGSINLVEHIVNDGldeekLSETISIAIRILDNVID---INFYPTKEAKE 734
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 456 -RLSH-TIGLGAMGLHTFFAKNHMEYGSEESLDFTDIYFMLLNYWTLMESNQIAKERNQVfhnfekSDYaSGAYFDKyie 533
Cdd:PRK12365 735 aNLAHrAIGLGVMGFQDALYKLNISYASQEAVEFADYSSELIAYYAILASSLLAKERGTY------SSY-KGSKWDR--- 804
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 534 gNFTPkFDKVkEIFKD------IQIPTA--EDWAALRDAVKKDGLYHQNRLAVAPNGSISYINDTSASIHPITR------ 599
Cdd:PRK12365 805 -GYLP-IDTI-ELLKEyrgeanLLMDTSsrKDWEPVRSLIKEYGMRNSQLMAIAPTATISNIIGVTQSIEPTYKhlfvks 881
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 600 ------------MIEerQEKKIG---------KIYYPAPYLANDTIP-----YYTSAYDMDMRKVIDVYATAQQHVDQGM 653
Cdd:PRK12365 882 nlsgeftipnvyLIE--KLKKLGiwdadmlddLKYFDGSLLEIERIPdhlkkIFLTAFEIEPEWIIECASRRQKWIDMGQ 959
|
650 660 670 680
....*....|....*....|....*....|....*....|....*...
gi 1350107710 654 SLTLFMRSeiPEGlyewketpkqttRDLNILRHYAFNKGIKSIYYIRT 701
Cdd:PRK12365 960 SLNLYLAE--PDG------------KKLSNMYLTAWKKGLKTTYYLRS 993
|
|
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
69-719 |
1.21e-51 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 191.86 E-value: 1.21e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 69 EFIEKYSMDFIEKLYAFLD-EQHFQFkSFMAAYKFYSQYALKNNAGTEYLETyeDRVAF---NALYFADGDEELALtlad 144
Cdd:PHA02572 116 EILSKYSAEEITYLESFIDhDRDFEF-TYAGAMQLKEKYLVQDRSTGEIYET--PQFAYmliAMALHQDEPKEDRL---- 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 145 EMIHQRYQPAT------PSFLNAG-RKRRGELVSCFLVQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKG 217
Cdd:PHA02572 189 EHVIRFYNAVStrkislPTPIMAGvRTPTRQFSSCVVIESGDSLDSINKTAMAIVKYISKRAGIGINAGMIRAEGSKIRG 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 218 YDGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIEMFLSAKKENADEKIRVKTLSLGVIVPDKFYELTRNN 297
Cdd:PHA02572 269 GEVRHTGVIPFWKHFQTAVKSCSQGGIRGGAATAYYPIWHLEVEDLLVLKNNKGVEENRIRHLDYGVQINDLMYERFIKN 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 298 EDMYLFSPYSV-EREYGVPYSYVDITKE-YDNLVANPNIRKRKIKARDLENEISKLQQESGYPYIINIDTANKNNPIDGK 375
Cdd:PHA02572 349 DYITLFSPHDVgGELYDAYFADQDRFRElYEALEKDPSVRKKRIKAQELFLLLLKERSETGRIYIMFIDHCNNHSPFKDP 428
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 376 IIMSNLCSEILQVQTPSvingkQEYEVLGTDISCNLGSTNIVNLMESPDFGKSVRAMTRALTFVTDASEIDVVPTIQNGN 455
Cdd:PHA02572 429 IRQSNLCCEIALPTKPL-----NHIDGEGEIALCTLSAIVLGNFEDQDEIEELAEVAVRALDNLLDYQDYPVPAALKAKK 503
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 456 RLShtIGLGAMGLHTFFAKNHMEYGSEESlDFTDIYFMLLNYWTLMESNQIAKERnqvfhnfeksdyasGA--YFD--KY 531
Cdd:PHA02572 504 RRS--LGVGVTNYAHYLAKNFASYEDANA-DLVHELFERLQYYLIKASNKLAKEK--------------GAceYFSdtKY 566
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 532 IEGNFTpkFDKVKEIFKDIQIPTAE-DWAALRDAVKKDGLYHQNRLAVAPNGSISYINDTSASIHPITRMIEERQEKKiG 610
Cdd:PHA02572 567 SRGELP--IDWYKKKVDELVAPKYNcDWESLREDLKKYGIRNSTLSALMPCESSSQVSNSTNGIEPPRGPVSIKKSKE-G 643
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 611 KIYYPAPYLaNDTIPYYTSAYDMDMRK---VIDVYATAQQHVDQGMSLTLFMRSEIpeglYEWKETPKQTTRDlNILRHY 687
Cdd:PHA02572 644 PFNQVVPNV-ETLKDLYDLLWDLAKKGnkgYLTQVAIMQKFVDQAISANTSYDPEN----YPNGKVPMSVMLD-DLLYFY 717
|
650 660 670
....*....|....*....|....*....|....*...
gi 1350107710 688 AFnkGIKSIYYIRTF----TDDAEEIGSNQ--CESCVI 719
Cdd:PHA02572 718 YY--GGKTLYYHNTRdgkgTEDYEIETPKAedCDSCKL 753
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
151-701 |
6.37e-50 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 188.63 E-value: 6.37e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 151 YQPATPSFLNAGrKRRGELVSCFLVQVTDDMNSIGRSI-NSALqLSRIGGGVGITLSNLREAGAPIKGYDGAASGVVPVM 229
Cdd:PRK07207 354 FMSSTPTLFNSG-TLRPQLSSCYLTTVPDDLDGIYEAIkDNAL-LSKFAGGLGNDWTPVRALGSHIKGTNGKSQGVVPFL 431
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 230 KLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIEMFLSAKKENADEKIRVKTLSLGVIVPDKFYELTRNNEDMYLFSPYSV- 308
Cdd:PRK07207 432 KVVNDTAVAVNQGGKRKGAVCAYLETWHLDIEEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRVMEDGEWTLFSPSEVp 511
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 309 --EREYGVPY--SYVditkEYDNLVANPNIRK-RKIKARDLENEISKLQQESGYPYIINIDTANKNNPID--GKIIMSNL 381
Cdd:PRK07207 512 dlHDLFGKAFeeAYT----AYEAKAARGEIKLfKKIPAVDLWRKMLSMLFETGHPWITFKDPCNLRSPQQhvGVVHSSNL 587
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 382 CSEIlqvqtpsVIN-GKQEYEVlgtdisCNLGSTNIVNLM---ESPDFGK---SVRAMTRALTFVtdaseIDV----VPT 450
Cdd:PRK07207 588 CTEI-------TLNtSDDEIAV------CNLGSVNLVAHIkdgAKLDHEKlkrTVSTAMRMLDNV-----IDInyyaVPK 649
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 451 IQNGNrLSH-TIGLGAMGLHTFFAKNHMEYGSEESLDFTDIYFMLLNYWTLMESNQIAKERNQvfhnfeksdYAS--GAY 527
Cdd:PRK07207 650 ARNSN-LRHrPVGLGIMGFQDALYLLRIPYASDEAVEFADRSMEAVSYYAIWASTELAEERGR---------YSSyeGSL 719
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 528 FDKYIegnfTPkFDKV----KEIFKDIQIPTAE--DWAALRDAVKKDGLYHQNRLAVAPNGSISYINDTSASIHPI---- 597
Cdd:PRK07207 720 WSRGI----LP-IDSLkllaEARGGYLEVDRSStlDWDALRARIKKHGMRNSNCMAIAPTATISNIIGVSQSIEPTyqnl 794
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 598 ---TRMIEE---------RQEKKIG----------KiYYPAPYLANDTIP-----YYTSAYDMDMRKVIDVYATAQQHVD 650
Cdd:PRK07207 795 yvkSNLSGEftvvnpylvRDLKARGlwdevmvndlK-YFDGSLQRIDRIPadlkaLYATAFEVDPRWLVEAASRRQKWID 873
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|.
gi 1350107710 651 QGMSLTLFMRSeiPEGlyewketpkqttRDLNILRHYAFNKGIKSIYYIRT 701
Cdd:PRK07207 874 QAQSLNLYMAG--ASG------------KKLDETYKLAWLRGLKTTYYLRT 910
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
67-699 |
2.48e-49 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 185.90 E-value: 2.48e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 67 ETEFIEKYSMDF-IEKLYAFLDEQHFQFKSFMAAYKFYSQYALKNNAGT--EYLETYEDRVAFNALYFADGDEELALTLA 143
Cdd:PRK06539 120 EGLLDSRLGGLFdLERLAAALDPTRDELLKYIGVVTLNNRYGIRARNGDalEVPQYFWMRIAMGLSLNEDDPTSSALAFY 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 144 DEMIHQRYQPATPSFLNAGRKRrGELVSCFLVQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYDGAAS 223
Cdd:PRK06539 200 EKMSKLEYLAAGSTLVNAGTPY-PQLSNCFVMEMQDDIEHIAKTTRDVMWLTKGTGGIGLSVSKLRAQGSPIRSNNTTST 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 224 GVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIEMFLSAKKENADEKIRVKTLSLGVIVPDKFYELTRNNEDMYLF 303
Cdd:PRK06539 279 GPIPFMHTIDSVLRAVSRGGKKFGALCFYMENWHMDFPEFLDLRQNSGDPYRRTRTANTAVWISDEFMKRVQNDEDWYLF 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 304 SPYSV---EREYGVPYSyvDITKEYDNLVANPNIRK-RKIKARDLENEISKLQQESGYPYIINIDTANKN--NPIDGKII 377
Cdd:PRK06539 359 DPLETpdlNELYGKAFS--KRYAQYVEQAEAGRIRMfKRITAREQFRAILMSLQTTSHPWLTWKDTINNRalNNNTGTIH 436
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 378 MSNLCSEILQVQTpsvingKQEYEVlgtdisCNLGSTNIVNLMESP--DFGK---SVRAMTRALTFVTDASeIDVVPTIQ 452
Cdd:PRK06539 437 LSNLCTEICLPQD------RDNVSV------CNLASINLSRHLADGelDWAQleeSTRLAVRQLDNLIDIT-ASSVKEAD 503
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 453 NGNRLSHTIGLGAMGLHTFFAKNHMEYGSEESLDFTDIYFMLLNYWTLMESNQIAKERNqVFHNFEKSDYASGayfdkyi 532
Cdd:PRK06539 504 FSNQQNRAIGLGVMGFTDMVERLGYSYESEEAYDLIDRIMEHISYAAIDESADLAAERG-AYPNFEGSRWSRG------- 575
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 533 egnFTPkFDKVKEIFKDIQIP------TAEDWAALRDAVkKDGLYHQNRLAVAPNGSISYINDTSASIHP---------- 596
Cdd:PRK06539 576 ---MVP-VDSIALLEADRGVPvdvnrtTRLDWDALRAKV-RGGMRNATLMAIAPTASIGLVAGTTPGLDPqfsqifsrst 650
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 597 -------ITR-MIEERQEKKI------------GKIY----YPAPYLANdtipyYTSAYDMDMRKVIDVYATAQQHVDQG 652
Cdd:PRK06539 651 ssgkfleVNRnLVADLKELGLwetvreeilrsqGDIQeiaaIPDEIKAL-----YRTSFQLSPYAFLEVAARAQKWVDQA 725
|
650 660 670 680
....*....|....*....|....*....|....*....|....*..
gi 1350107710 653 MSLTLFMRSeipeglyewketpkQTTRDLNILRHYAFNKGIKSIYYI 699
Cdd:PRK06539 726 ISRNMYLES--------------RDIGDMMDIYTAAWEMGVKTTYYL 758
|
|
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
146-716 |
7.24e-46 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 175.70 E-value: 7.24e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 146 MIHQRY-QPATPSFLNAGRKRrGELVSCFLVQVTDD-MNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYDGAAS 223
Cdd:PLN02437 192 LMSQRWfTHASPTLFNAGTPR-PQLSSCFLICMKDDsIEGIYDTLKECAVISKSAGGIGLSVHNIRATGSYIRGTNGTSN 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 224 GVVPVMKLFEDSFSYSNQLG-QRQGAGVVYLNVFHPDIEMFLSAKKENADEKIRVKTLSLGVIVPDKFYELTRNNEDMYL 302
Cdd:PLN02437 271 GIVPMLRVFNDTARYVDQGGgKRKGAFAIYLEPWHADIFEFLDLRKNHGKEEHRARDLFYALWIPDLFMERVQSNGDWSL 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 303 FSPysvEREYGVPYSYVDitkEYDNLVA---NPNIRKRKIKARDLENEISKLQQESGYPYIINIDTANK--NNPIDGKII 377
Cdd:PLN02437 351 FCP---NEAPGLADCWGE---EFERLYTkyeREGKAKKVVQAQQLWFAILESQIETGTPYMLFKDSCNRksNQQNLGTIK 424
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 378 MSNLCSEILQVQTPSvingkqEYEVlgtdisCNLGS------------------TNIVNLMESP----DFGKsVRAMTRA 435
Cdd:PLN02437 425 SSNLCTEIIEYTSPT------ETAV------CNLASialprfvrekgvpleshpSKLVGSLGSKnryfDFEK-LAEVTAV 491
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 436 LTFVTDASeIDV----VPTIQNGNRLSHTIGLGAMGLHTFFAKNHMEYGSEESLDFTDIYFMLLNYWTLMESNQIAkERN 511
Cdd:PLN02437 492 VTRNLNKI-IDVnyypVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALKASSELA-ARE 569
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 512 QVFHNFEKSDYASGAY-FDKYiegNFTPKfdkvkeifkdiqipTAEDWAALRDAVKKDGLyhQNRLAVA--PNGSISYIN 588
Cdd:PLN02437 570 GPYETYAGSPVSKGILqPDMW---GVTPS--------------GRWDWAALREMISKNGV--RNSLLVApmPTASTSQIL 630
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 589 DTSASIHPITRMIEER-------------------------QEKKIGKIYYPAPYLANDTIP-----YYTSAYDMDMRKV 638
Cdd:PLN02437 631 GNNECFEPYTSNIYSRrvlsgefvvvnkhllhdltemglwtPTLKNKIIAENGSVQKIPEIPddlkaIYKTVWEIKQRTL 710
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 639 IDVYATAQQHVDQGMSLTLFMrseipeglyewketPKQTTRDLNILRHYAFNKGIKS-IYYIRT--------FTDDAEEI 709
Cdd:PLN02437 711 VDMAADRGCYIDQSQSLNIHM--------------DQPNFGKLTSLHFYAWSKGLKTgMYYLRSraaadaikFTVDTASL 776
|
....*..
gi 1350107710 710 GSNQCES 716
Cdd:PLN02437 777 KPSATGV 783
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
106-523 |
8.61e-39 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 153.94 E-value: 8.61e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 106 YALKNNAGTEyLETYED---RVAfNALYFADGD-------EELALTLADEMIHQRYQPATPSFLNAGRkRRGELVSCFLV 175
Cdd:PRK08665 24 YLKKDEDGKP-IETPEDmfrRVA-RTIAAAELIydskadvEALADRFYDLMTSLEFLPNSPTLMNAGR-ELGQLSACFVL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 176 QVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYDGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNV 255
Cdd:PRK08665 101 PVGDSIEEIFDAVKHAALIHKSGGGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFDAATEAIKQGGTRRGANMGILRV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 256 FHPDIEMFLSAKKENAdeKIRVKTLSLGVIvpDKFYELTRNNEDMYLFSPYSVEreygvpysyvditkeydnlvanpniR 335
Cdd:PRK08665 181 DHPDIMEFITCKEDNG--ELTNFNISVAIT--EAFMEAVEADEEYDLINPRTGE-------------------------V 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 336 KRKIKARDLENEISKLQQESGYPYIINIDTANKNNPID--GKIIMSNLCSEilQVQTPsvingkqeYEvlgtdiSCNLGS 413
Cdd:PRK08665 232 VGRLNAREVFDLIVEMAWENGEPGIVFIDRINRDNPTPhlGEIESTNPCGE--QPLLP--------YE------SCNLGS 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 414 TNIVNLMESPDF-----GKSVRAMTRALTFVTDASE--IDVVPTIQNGNRlshTIGLGAMGLHTFFAKNHMEYGSEESLD 486
Cdd:PRK08665 296 INLSKMVKNGDVdweklREVVHLAVRFLDNVIDANKypLPQIEEMTKGNR---KIGLGVMGWADMLIQLGIPYDSEEAVE 372
|
410 420 430
....*....|....*....|....*....|....*..
gi 1350107710 487 FTDIYFMLLNYWTLMESNQIAKERNqVFHNFEKSDYA 523
Cdd:PRK08665 373 LAEKVMKFIQDEAHAASRELAEERG-PFPNYEGSIYD 408
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
143-662 |
3.23e-37 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 149.23 E-value: 3.23e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 143 ADEMIHQRYQPATPSFLNAGRKRrGELVSCFLVQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYDGAA 222
Cdd:PRK06406 224 EEVMSNLKFVPNSPTLMNAGTKL-GQLSACFVLPVPDSIEGIFNALKYTAMIHKSGGGTGFSFSRLRPKDDIVASTKGVA 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 223 SGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIEMFLSAKkeNADEKIrVKTLSLGVIVPDKFYELTRNNEdmyl 302
Cdd:PRK06406 303 SGPLSFMRIFDVTTDVIKQGGKRRGANMGILSYHHPDIMEFITSK--DSENKV-LSNFNISVAVTDEFFDKLDNDD---- 375
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 303 fspysvereygvpysYVDITkeydnlvaNPNIRK--RKIKARDLENEISKLQQESGYPYIINIDTANKNNPID--GKIIM 378
Cdd:PRK06406 376 ---------------YYPLR--------NPRNGKevKRIKARQVWDLIITQAWKTGDPGVIFLDEINRKNPVKnlGEIES 432
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 379 SNLCSEilQVQTPsvingkqeYEvlgtdiSCNLGSTNIVNLMES-----PDFGKSVRAMTRALTFVTDASEIDvVPTIQN 453
Cdd:PRK06406 433 TNPCGE--QPLLP--------YE------SCNLGSINLSKFVENgkidwDRLRETVHIATRFLDNVIDANKFP-VPQIKE 495
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 454 GNRLSHTIGLGAMGLHTFFAKNHMEYGSEESLDFTDIYFMLLNYWTLMESNQIAKERNqVFHNFEKSDYasgayfdkyie 533
Cdd:PRK06406 496 MTRMTRKIGLGVMGFADMLIKLGIPYNSEEALEIAEKVMKFINEESHRASQKLAEERG-VFPAWYGSEW----------- 563
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 534 gnftpkfdkvkeifkdiqiptaedwaalrdavKKDGLYHQNR--LAVAPNGSISYINDTSASIHPI-----TRMIEERQE 606
Cdd:PRK06406 564 --------------------------------EKKGIKMRNSttTTIAPTGTISIIAGCSSSIEPLfaiafVRHVLNGQE 611
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 607 ------------KKIGkIYYP--------APYLANDTIP-----YYTSAYDMDMRKVIDVYATAQQHVDQGMSLTLFMRS 661
Cdd:PRK06406 612 llevnplfeeitRKRG-LYSEelmrkvaeTGNLQNIDVPedikrIFVTAHEIDPQWHVLMQATFQRYCDSGVSKTINLRY 690
|
.
gi 1350107710 662 E 662
Cdd:PRK06406 691 D 691
|
|
| RNR_N |
pfam08343 |
Ribonucleotide reductase N-terminal; This domain is found at the N-terminus of bacterial ... |
11-91 |
3.81e-34 |
|
Ribonucleotide reductase N-terminal; This domain is found at the N-terminus of bacterial ribonucleoside-diphosphate reductases (ribonucleotide reductases, RNRs) which catalyze the formation of deoxyribonucleotides. It occurs together with the RNR all-alpha domain (pfam00317) and the RNR barrel domain (pfam02867).
Pssm-ID: 429933 Cd Length: 82 Bit Score: 124.87 E-value: 3.81e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 11 YFKLNNEINRPV-DGQIPLNKDKEALAAFFKENVEPNTRKFSSAEEKINFLMKEDFIETEFIEKYSMDFIEKLYAFLDEQ 89
Cdd:pfam08343 1 YIALNNELNLYDeNGKIQFDKDKEALEAYFKEHVNPNTVFFHSLKEKLDYLVENDYYEEEFLNKYSFEFIEELYKYAYSY 80
|
..
gi 1350107710 90 HF 91
Cdd:pfam08343 81 KF 82
|
|
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
171-719 |
7.40e-31 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 129.34 E-value: 7.40e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 171 SCFLVQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYDGAASGVVPVMKLFEDSFSYSNQLGQRQGAGV 250
Cdd:PRK09103 221 SCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAAT 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 251 VYLNVFHPDIEMFLSAKKENADEKIRVKTLSLGVIVPDKFYELTRNNEDMYLFSPYSVEREYGVPYSYVDitkEYDNLV- 329
Cdd:PRK09103 301 LFYPIWHLEVESLLVLKNNRGVEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPSDVPGLYDAFFADQD---EFERLYt 377
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 330 ---ANPNIRKRKIKARDLeneISKLQQE---SGYPYIINIDTANKNNPIDGK---IIMSNLCSEILQVQTP-SVINGKQE 399
Cdd:PRK09103 378 kyeQDDSIRKKRVKAVEL---FSLMMQErasTGRIYIQNVDHCNTHSPFDPKvapVRQSNLCLEIALPTKPlNDVNDENG 454
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 400 YEVLGTDISCNLGSTNIVNLMESPDFgKSVRAMTRALTFvTDASeidvVPTIQNGNRLSHTIGLGAMGLHTFFAKNHMEY 479
Cdd:PRK09103 455 EIALCTLSAFNLGAINSLDELEELAD-LAVRALDALLDY-QDYP----IPAAKRGAMGRRTLGIGVINFAYYLAKNGVRY 528
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 480 GSEESLDFTDIYFMLLNYWTLMESNQIAKERNQVfHNFEKSDYASGAY-FDKYiegnftpkfdkVKEIFKDIQIPTAEDW 558
Cdd:PRK09103 529 SDGSANNLTHKTFEAIQYYLLKASNELAKEQGAC-PWFNETTYAQGILpIDTY-----------KKDLDAICNEPLHYDW 596
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 559 AALRDAVKKDGLYHQNRLAVAPNGSISYINDTSASIHPITRMIEERQEKK-IGKIYYPAPYLANDTipyYTSAYDM-DMR 636
Cdd:PRK09103 597 ETLREEIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDgILKQVVPDYERLKDA---YELLWEMpNND 673
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 637 KVIDVYATAQQHVDQGMSL-TLFMRSEIPEGlyewKETPKQTTRDLniLRHYAFnkGIKSIYYIRT-------FTDDAEE 708
Cdd:PRK09103 674 GYLQLVGIMQKFVDQSISAnTNYDPSRFPSG----KVPMKQLLKDL--LTAYKF--GVKTLYYHNTrdgaedaQDDLQPS 745
|
570
....*....|...
gi 1350107710 709 IGSNQCES--CVI 719
Cdd:PRK09103 746 IQDDGCEGgaCKI 758
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
102-657 |
3.59e-21 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 98.76 E-value: 3.59e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 102 FYSQYALKNNAGTEYLETYEDR--VAFNALYfadgdeelaltlaDEMIHQRYQPATPSFLNAGRKRRGELVSCFLVQ-VT 178
Cdd:PRK08115 130 FYEQIAKRNATGLAAVEKTEEKrkESFEKFY-------------QELVNMNFVPAGRVLYGAGSKTDVTYFNCYVMPfVK 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 179 DDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYDGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHP 258
Cdd:PRK08115 197 DSREGISEHRKQVMEIMSRGGGVGTNGSTLRPRNTLARGVNGKSSGSVSWLDDIAKLTHLVEQGGSRRGAQMIMLADWHP 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 259 DIEMFLSAKKEN-------------------ADEKIRVKTLS-------------------------------------- 281
Cdd:PRK08115 277 DILEFIISKMQNprilryllentedeqikrlVKEKLKFTPLSeveeamyqaivnykniegqggfdtkvikeaenklrtgg 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 282 --------------LGVIVPDKFYELTRNNEDMYLFSP----YSVE--REYGVPYSYVDITKEYDNLvANPNIRKRKIKA 341
Cdd:PRK08115 357 tytvnnpefltganISVCLTKEFMEAVENDEEYELRFPdvenYTEEemEIYNEEWHEVGDVREWEKM-GYPVRTYRKIKA 435
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 342 RDLENEISKLQQESGYPYIINIDTANK--NNPIDG-KIIMSNLCSEilQVQTPsvingkqeYEVlgtdisCNLGSTNIVN 418
Cdd:PRK08115 436 KELWNLINICATYSAEPGIFFIDNANEmtNAKAYGqKVVATNPCGE--QPLAP--------YSV------CNLAAINLAN 499
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 419 LMESP----DFGKSVRAMTRALTFVTDAseIDVVPTIQNGNRLS----HTIGLGAMGLHTFFAKNHMEYGSEESLDFTDI 490
Cdd:PRK08115 500 MADKEtktvDYEKLKRTVEVGVRMQDNV--IDATPYFLEENKKQalgeRRVGLGVMGLHDLLIYCETVYGSEEGNQLVDQ 577
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 491 YFMLLNYWTLMESNQIAKERNQVFHNFEKSDYASGAYFDKYIEGNFtpkfdkVKEIFKDIqiptaedwaalRDAVKKDGL 570
Cdd:PRK08115 578 IFETIATTAYRTSIELAKEKGSFPFLVGQTEEETAKLREAFINTGY------MKKMPEDI-----------REDILKYGI 640
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 571 YHQNRLAVAPNGSISYINDTSASIHP-----------ITRMIEERQEkkIGKIYYPA-PYLANDTIP-YYTSAYDMDMRK 637
Cdd:PRK08115 641 RNSHLLTVAPTGSTGTMVGVSTGLEPyfsfsyyrsgrLGKFIEVKAD--IVQEYLDKhPEADENHLPeWFISAMELKPEA 718
|
650 660
....*....|....*....|
gi 1350107710 638 VIDVYATAQQHVDQGMSLTL 657
Cdd:PRK08115 719 HADVQCIIQRWVDSSLSKTV 738
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
160-659 |
1.11e-17 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 87.16 E-value: 1.11e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 160 NAGRKRRGELVSCFL------VQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYDGAASGVVPVMKLFE 233
Cdd:PRK06948 76 NAGAAPDQTMVNCFVhpirapAALTAVHPNLDRALDDARLTLLMGGGIGYDFSAIPPADARPDADHPDSPGVCAALDRFD 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 234 DSFSYSNQLGQRQGAGVVYLNVFHPDIEMFLSAKKENAdekiRVKTLSLGVIVPDKFYELTRNNEDMYLFSPYSVEREYG 313
Cdd:PRK06948 156 RICAALPFRDGRRGAQMAVLRCDHPDLLAFVAAKRGRA----RWTTFNLSVAVTDAFMQAVAQDLPWALRHRAPPRRAAG 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 314 VPYSYVDITKEYDNlvanpnirkrkIKARDLENEISKLQQESGYPYIINIDTANKNNPIDG--KIIMSNLCseilqvqtp 391
Cdd:PRK06948 232 GALRGADGAWTYAT-----------VPARHLWREIVSAARDSAEPGLLFVDTIDAANPLREheRIDATNPC--------- 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 392 svinGKQEYEVLGtdiSCNLGSTNIVNLMESP---------DF---GKSVRAMTRALTFVTDASEIDvVPTIQNGNRLSH 459
Cdd:PRK06948 292 ----GEQPLPPYG---SCVLGPIDLSRFVRHPfgvggeprfDFaalATAVRIQVRMLDNALDLTRWP-LAAHAREARQKR 363
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 460 TIGLGAMGLHTFFAKNHMEYGSEESLDFTDIYFMLLNYWTLMESNQIAKERNqVFHNFEKSDYASGAYFdkyieGNFTPK 539
Cdd:PRK06948 364 RIGVGVTGLADALTMMRLRYDSPAAREMARYIASDLRHHAYAASAALAAERG-AYPLCDPAAHLDALRA-----GPPLPH 437
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 540 fdkvkeifkdiqiptaedwaALRDAVKKDGLYHQNRLAVAPNGSIS--YINDTSASIHPITRMIEERQEKKIGKiyYPAP 617
Cdd:PRK06948 438 --------------------AVCHAIARHGLRNSHLLSFAPVGSVSlaFGDNCSPGIEPARAWIEHRPVRAGAG--GARG 495
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 1350107710 618 YLAND--------------TIP-YYTSAYDMDMRKVIDVYATAQQHVDQGMSLTLFM 659
Cdd:PRK06948 496 MRAENhayrlfrslrgeraALPdYFVTAADVAPADHLAMRAALQPYVDAGISKTVTL 552
|
|
| PRK06556 |
PRK06556 |
vitamin B12-dependent ribonucleotide reductase; Validated |
116-468 |
8.47e-16 |
|
vitamin B12-dependent ribonucleotide reductase; Validated
Pssm-ID: 235828 [Multi-domain] Cd Length: 953 Bit Score: 81.56 E-value: 8.47e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 116 YLETYEDRVAFnalyfadgDEELALTLademIHQRYQPATPSFLNAGRKRRGELVSCFLVQVTDDMNSIGRSINSALQLS 195
Cdd:PRK06556 108 YFATEEDAEIF--------EHELTWLL----LHQKFSFNSPVWFNVGTESPQQVSACFILSVDDSMESILNWYKEEGMLF 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 196 RIGGGVGITLSNLREAGAPIKGyDGAASGVVPVMKLFeDSFSYSNQLG--QRQGAGVVYLNVFHPDIEMFLSAK-KEnaD 272
Cdd:PRK06556 176 KGGSGTGTNLSRIRSSKELLSG-GGTASGPVSFMRGA-DASAGTIKSGgaTRRAAKMVILDVDHPDIEEFIETKaKE--E 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 273 EKIRVktlsLGvivpDKFYELTRNNEDmylfspysvereygvpYSYVditkEYDNlvANPNIR----------------- 335
Cdd:PRK06556 252 DKIRA----LR----DAGYDMDLGGEA----------------YSSV----QYQN--ANNSVRvsdefmravendgefgl 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 336 --------KRKIKARDLENEISKLQQESGYPYIINIDTANK--NNPIDGKIIMSNLCSeilqvqtpsvingkqEYEVLgT 405
Cdd:PRK06556 302 rartdgevIETVDAKELFRKIAEAAWECADPGIQYDDTINDwhTCPESGRINASNPCS---------------EYMFL-D 365
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1350107710 406 DISCNLGSTNIVNLMeSPDFGKSVRAMTRALTFVTDASEIDV----VPT--IQNGNRLSHTIGLG---------AMGL 468
Cdd:PRK06556 366 NSSCNLASLNLMKFL-RDDGTFDVESFRHAVELVITAMEISIcfadFPTekIARNTRAFRQLGLGyanlgallmATGL 442
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
399-617 |
3.84e-15 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 79.81 E-value: 3.84e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 399 EYEvlgtdiSCNLGSTNIVNLMESPDFGKS----------VRAMTRALTFVTDASEIDVvPTIQNGNRLSHTIGLGAMGL 468
Cdd:PRK08332 1304 EYE------SCNLASINLAKFVKYDENGKPyfdwdeyayvIQKVAKYLDNAIDVNKFPL-PEIDYNTKLTRRIGVGMMGL 1376
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 469 HTFFAKNHMEYGSEESLDFTDIYFMLLNYWTLMESNQIAKERNqVFHNFEKSDYASGAYfdkYIEGNFTPkfdkvkEIFk 548
Cdd:PRK08332 1377 ADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRG-TFPLYEKTEYPKGEL---PVEGFYHP------EIW- 1445
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1350107710 549 diQIPtaedWAALRDAVKKDGLYHQNRLAVAPNGSISYINDTSASIHPITRMIeERQEKKIGKIYYPAP 617
Cdd:PRK08332 1446 --NLP----WDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALV-YKKSVTVGEFYYVDP 1507
|
|
| Ribonuc_red_lgN |
pfam00317 |
Ribonucleotide reductase, all-alpha domain; |
95-164 |
7.71e-15 |
|
Ribonucleotide reductase, all-alpha domain;
Pssm-ID: 459758 [Multi-domain] Cd Length: 75 Bit Score: 69.96 E-value: 7.71e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1350107710 95 SFMAAYKFYSQYALKNNAGtEYLETYEDRVAFNALYFA-----DGDEELALTLADEMIHQRYQPATPSFLNAGRK 164
Cdd:pfam00317 2 TYLGAKVLEDRYLLKDEDG-ELLETPQDMFMRVALALAgaeleEDRLELAEEFYDLLSSLKFLPATPTLMNAGTP 75
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
202-382 |
8.03e-09 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 59.39 E-value: 8.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 202 GITLSNLREAGAPIKGYDGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLNVFHPDIEMFLSAKKENADEKIrVKTLS 281
Cdd:PRK08332 757 GLNFSKLRPEGDIVGTTTGAASGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKEKNIGTNV-LSNFN 835
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 282 LGVIVPDKFYELTRNNEDMYLFSPYSVEreygvpysyvdITKEYDnlvanpnirkrkikARDLENEISKLQQESGYPYII 361
Cdd:PRK08332 836 ISVGIWEDFWEALKEGKKYPLINPRTGE-----------VVKEID--------------PKSLFEELAYMAWAKADPGVI 890
|
170 180
....*....|....*....|....*
gi 1350107710 362 NIDTANKNNPID----GKIIMSNLC 382
Cdd:PRK08332 891 FFDVINRRNVLKeakgGPIRATNPC 915
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
69-329 |
3.62e-06 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 50.53 E-value: 3.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 69 EFIEKYSMDFIEklyafLDEQHFQfkSFMAAYKFYSQYALKNNAGTEYLETYEdRVAFNAlYFADGDEELALtladeMIH 148
Cdd:PRK08332 185 EFDGKYSIGKYK-----LNKYHFE--RMVNLYRELAEKGKMKVSIDEFLKMLE-RGEFDK-YEKEIEEYFRL-----MTN 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 149 QRYQPATPSFLNAGRKRrGELVSCFLVQVTDDMNSIGRSINSALQLSRIGGGVgitlsnlREAGAPIKGYDGAASGVVPV 228
Cdd:PRK08332 251 QIFMPNTPALINSGRPL-GMLSACFVVPIEDDMESIMKAAHDVAMIQKAGGGC-------IDGNAKIIFENEGEEHLTTM 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 229 MKLFE---DSFSYSNQLGQRQGAGVVYLNVFhpdIEMFLSAKKENADEKIRVK-TLSLGVIVPDkfYELTRNNEDMYLFS 304
Cdd:PRK08332 323 AEMYErykHLGEFYDEEYNRWGIDVSEVPIY---VKSFDPETKRVVKGKVKVIwKYELGEDVPK--YEIKTNKGTKILTS 397
|
250 260
....*....|....*....|....*....
gi 1350107710 305 P----YSVEREYGVPYSYVDITKEYDNLV 329
Cdd:PRK08332 398 PwhpfFVLTPDFKIVEKRADELKEGDILI 426
|
|
| RNR_PFL |
cd00576 |
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ... |
157-303 |
4.01e-04 |
|
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 43.29 E-value: 4.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 157 SFLNAGRKRRGELVSCFLVQVTD-----------DMNSIGRSINSALQL------SRIGGGVGIT--LSNLREAGAPIKG 217
Cdd:cd00576 10 SGVITVGRPDLPFTGCVLVDYGDsldpgikgvneTAKSINEAIQKTYQIialaasNQNGGGVSFAraSSILSPYGSRDYA 89
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1350107710 218 Y-DGAASGVVPVMKLFEDSFSYSNQLGQRQGA-----GVVYLNVFHPDIEMFLSAKKENADEKIRVKTLSLGVIVPDKFY 291
Cdd:cd00576 90 KgSGTETDAVEAADAFNLALKEVGQGNGRTGAatgfiGGVHKGKGDKISQEFLNLALANGGEGIPLNFPNLSVRVSSDKP 169
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170
....*....|..
gi 1350107710 292 ELTRNNEDMYLF 303
Cdd:cd00576 170 GILVKAVELKQL 181
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