|
Name |
Accession |
Description |
Interval |
E-value |
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
12-463 |
7.80e-176 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 500.75 E-value: 7.80e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 12 IHFVGIggigmsgiAELMLDLGYNIQGSDINLSENIQRLKKKGIKFFKGHDKKNIKNITAVVFSSAIKKNNPELIECKRL 91
Cdd:COG0773 7 IHFIGIggigmsglAEILLALGYKVSGSDLAESPMTERLEALGIPVFIGHDAENIDDADLVVVSSAIPRDNPELVAARER 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 92 SIPLVSRADMLSELMKTKKSIAVAGSHGKTTTTSLVGSILDYAKFDPTIVNGGIINSYSKNNRFGLGEWMVVEADESDGT 171
Cdd:COG0773 87 GIPVLSRAEMLAELMRGKRSIAVAGTHGKTTTTSMLAHILEEAGLDPTFLIGGILNNFGTNARLGDGDYFVAEADESDGS 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 172 FLRLPHEINIITNLDIEHLDYYKNKDNLIKAFKNFINNLPFYGYSILCTDNNNLKRLSKEIKTRnIITYSKNqKTSDVKI 251
Cdd:COG0773 167 FLHYSPDIAVVTNIEADHLDIYGDLEAIKEAFHEFARNVPFYGLLVLCADDPGLRELLPRCGRP-VITYGFS-EDADYRA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 252 TSIKKNKKSTEFLLFINKNIIDgiggnyKFKINLLGEHNILNATGAIIASLLAKVSIQKIQQSLLNFEGVKRRFSYLGNI 331
Cdd:COG0773 245 ENIRIDGGGSTFDVLRRGEELG------EVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRFELKGEV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 332 QNAAIYDDYAHHPSEIKASYEIAKHLA-EKKIIVIFQPHRYSRTKYLFNDFINILQKINYLYIMDIYPAGEKPIKGVNSK 410
Cdd:COG0773 319 GGVTVIDDYAHHPTEIAATLAAAREKYpDRRLVAVFQPHRYSRTRDFLDEFAEALSLADEVILLDIYAAREKPIPGVSSE 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 1347645560 411 NLVNKIKNKNKNTFYLSNKDNLQHKLKPYFKKNNIIIFMGAGSITYYAENLIK 463
Cdd:COG0773 399 DLAEAIRKRGKDVVYVPDLDELVEALAEIARPGDVVLTMGAGDIGGLGEKLLE 451
|
|
| murC |
TIGR01082 |
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ... |
12-462 |
8.47e-142 |
|
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273433 [Multi-domain] Cd Length: 448 Bit Score: 414.01 E-value: 8.47e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 12 IHFVGIGGIGMSGIAELMLDLGYNIQGSDINLSENIQRLKKKGIKFFKGHDKKNIKNITAVVFSSAIKKNNPELIECKRL 91
Cdd:TIGR01082 2 IHFVGIGGIGMSGIAEILLNRGYQVSGSDIAENATTKRLEALGIPIYIGHSAENLDDADVVVVSAAIKDDNPEIVEAKER 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 92 SIPLVSRADMLSELMKTKKSIAVAGSHGKTTTTSLVGSILDYAKFDPTIVNGGIINSYSKNNRFGLGEWMVVEADESDGT 171
Cdd:TIGR01082 82 GIPVIRRAEMLAELMRFRHSIAVAGTHGKTTTTAMIAVILKEAGLDPTVVVGGLVKEAGTNARLGSGEYLVAEADESDAS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 172 FLRLPHEINIITNLDIEHLD-YYKNKDNLIKAFKNFINNLPFYGYSILCTDNNNLKRLSKEIkTRNIITYSKNQKTSDVK 250
Cdd:TIGR01082 162 FLHLQPNVAIVTNIEPDHLDtYGSSFERLKAAFEKFIHNLPFYGLAVICADDPVLRELVPKA-TEQVITYGGSGEDADYR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 251 ITSIKKNKKSTEFLLFINKNiidgigGNYKFKINLLGEHNILNATGAIIASLLAKVSIQKIQQSLLNFEGVKRRFSYLGN 330
Cdd:TIGR01082 241 AENIQQSGAEGKFSVRGKGK------LYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGVKRRFEILGE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 331 IQNAAIYDDYAHHPSEIKASYEIAKHLA-EKKIIVIFQPHRYSRTKYLFNDFINILQKINYLYIMDIYPAGEKPIKGV-N 408
Cdd:TIGR01082 315 FGGVLLIDDYAHHPTEIKATLKAARQGYpDKRIVVVFQPHRYSRTRDLFDDFAKVLSDADELILLDIYAAGEEPINGIdG 394
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1347645560 409 SKNLVNKIKNKNKNTFYLSNKDNLQHKLKPYFKKNNIIIFMGAGSITYYAENLI 462
Cdd:TIGR01082 395 KSLARKITQLGKIEPYFVPDLAELVEFLAAVLQSGDLILTMGAGDIIKLARELL 448
|
|
| PRK14573 |
PRK14573 |
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase; |
9-469 |
2.54e-74 |
|
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
Pssm-ID: 184752 [Multi-domain] Cd Length: 809 Bit Score: 249.35 E-value: 2.54e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 9 KIIIHFVGIGGIGMSGIAELMLDLGYNIQGSDINLSENIQRLKKKGIKFFKGHDKKNIKNITAVVFSSAIKKNNPELIEC 88
Cdd:PRK14573 4 SLFYHFIGIGGIGMSALAHILLDRGYSVSGSDLSEGKTVEKLKAKGARFFLGHQEEHVPEDAVVVYSSSISKDNVEYLSA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 89 KRLSIPLVSRADMLSELMKTKKSIAVAGSHGKTTTTSLVGSILDYAKFDPTIVNGGiINSYSKNNRFGLGEWMVVEADES 168
Cdd:PRK14573 84 KSRGNRLVHRAELLAELMQEQISILVSGSHGKTTVSSLITAIFQEAKKDPSYAIGG-LNQEGLNGYSGSSEYFVAEADES 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 169 DGTFLRLPHEINIITNLDIEHLDYYK-NKDNLIKAFKNFIN-----NLPFYgysilctdNNNLKRLSKEIKTrniITYSK 242
Cdd:PRK14573 163 DGSLKHYTPEFSVITNIDNEHLSNFEgDRELLLASIQDFARkvqqiNKCFY--------NGDCPRLKGCLQG---HSYGF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 243 NQkTSDVKITSIKKNKKSTEFLL-FINKNIIDgiggnykFKINLLGEHNILNATGAIIASLLAKVSIQKIQQSLLNFEGV 321
Cdd:PRK14573 232 SS-SCDLHILSYYQEGWRSYFSAkFLGVVYQD-------IELNLVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGV 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 322 KRRFSYLGNIQNAAIYDDYAHHPSEIKASYE-IAKHLAEKKIIVIFQPHRYSRTKYLFNDFINILQKINYLYIMDIYPAG 400
Cdd:PRK14573 304 QRRLERKNSSETFLFLEDYAHHPSEISCTLRaVRDAVGLRRIIAICQPHRFSRLRECLDSFPSAFQDADEVILTDVYSAG 383
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1347645560 401 EKPIKGVNSKNLVNKIKNKNKNTFYLSNKDNLQHKLKPYFKKNNIIIFMGAGSItYYAENLIKNNNAKK 469
Cdd:PRK14573 384 EEPEDSISYQKLAEAISQSSIVKCTYVPFHEIQRYLEQSIRVHDVCVSLGAGNI-YTLGEALKDFEPKK 451
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
114-300 |
1.98e-26 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 105.85 E-value: 1.98e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 114 VAGSHGKTTTTSLVGSILDYA-KFDPTIVNGGIINSYSKNNRFGL-----------GEWMVVEADESDGTFLRL----PH 177
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAgGVIGTIGTYIGKSGNTTNNAIGLpltlaemveagAEYAVLEVSSHGLGEGRLsgllKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 178 EINIITNLDIEHLDYYKNKDNLIKAFKNFINNLPFYGYSILCTDNNNLKRLSKEIKTRN--IITYSKNQKtSDVKITSIK 255
Cdd:pfam08245 81 DIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLKKAGvrVITYGIEGE-ADLRAANIE 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1347645560 256 KNKKSTEFLLFinkniiDGIGGNYKFKINLLGEHNILNATGAIIA 300
Cdd:pfam08245 160 LSSDGTSFDLF------TVPGGELEIEIPLLGRHNVYNALAAIAA 198
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
12-463 |
7.80e-176 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 500.75 E-value: 7.80e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 12 IHFVGIggigmsgiAELMLDLGYNIQGSDINLSENIQRLKKKGIKFFKGHDKKNIKNITAVVFSSAIKKNNPELIECKRL 91
Cdd:COG0773 7 IHFIGIggigmsglAEILLALGYKVSGSDLAESPMTERLEALGIPVFIGHDAENIDDADLVVVSSAIPRDNPELVAARER 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 92 SIPLVSRADMLSELMKTKKSIAVAGSHGKTTTTSLVGSILDYAKFDPTIVNGGIINSYSKNNRFGLGEWMVVEADESDGT 171
Cdd:COG0773 87 GIPVLSRAEMLAELMRGKRSIAVAGTHGKTTTTSMLAHILEEAGLDPTFLIGGILNNFGTNARLGDGDYFVAEADESDGS 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 172 FLRLPHEINIITNLDIEHLDYYKNKDNLIKAFKNFINNLPFYGYSILCTDNNNLKRLSKEIKTRnIITYSKNqKTSDVKI 251
Cdd:COG0773 167 FLHYSPDIAVVTNIEADHLDIYGDLEAIKEAFHEFARNVPFYGLLVLCADDPGLRELLPRCGRP-VITYGFS-EDADYRA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 252 TSIKKNKKSTEFLLFINKNIIDgiggnyKFKINLLGEHNILNATGAIIASLLAKVSIQKIQQSLLNFEGVKRRFSYLGNI 331
Cdd:COG0773 245 ENIRIDGGGSTFDVLRRGEELG------EVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRFELKGEV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 332 QNAAIYDDYAHHPSEIKASYEIAKHLA-EKKIIVIFQPHRYSRTKYLFNDFINILQKINYLYIMDIYPAGEKPIKGVNSK 410
Cdd:COG0773 319 GGVTVIDDYAHHPTEIAATLAAAREKYpDRRLVAVFQPHRYSRTRDFLDEFAEALSLADEVILLDIYAAREKPIPGVSSE 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 1347645560 411 NLVNKIKNKNKNTFYLSNKDNLQHKLKPYFKKNNIIIFMGAGSITYYAENLIK 463
Cdd:COG0773 399 DLAEAIRKRGKDVVYVPDLDELVEALAEIARPGDVVLTMGAGDIGGLGEKLLE 451
|
|
| murC |
TIGR01082 |
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ... |
12-462 |
8.47e-142 |
|
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273433 [Multi-domain] Cd Length: 448 Bit Score: 414.01 E-value: 8.47e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 12 IHFVGIGGIGMSGIAELMLDLGYNIQGSDINLSENIQRLKKKGIKFFKGHDKKNIKNITAVVFSSAIKKNNPELIECKRL 91
Cdd:TIGR01082 2 IHFVGIGGIGMSGIAEILLNRGYQVSGSDIAENATTKRLEALGIPIYIGHSAENLDDADVVVVSAAIKDDNPEIVEAKER 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 92 SIPLVSRADMLSELMKTKKSIAVAGSHGKTTTTSLVGSILDYAKFDPTIVNGGIINSYSKNNRFGLGEWMVVEADESDGT 171
Cdd:TIGR01082 82 GIPVIRRAEMLAELMRFRHSIAVAGTHGKTTTTAMIAVILKEAGLDPTVVVGGLVKEAGTNARLGSGEYLVAEADESDAS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 172 FLRLPHEINIITNLDIEHLD-YYKNKDNLIKAFKNFINNLPFYGYSILCTDNNNLKRLSKEIkTRNIITYSKNQKTSDVK 250
Cdd:TIGR01082 162 FLHLQPNVAIVTNIEPDHLDtYGSSFERLKAAFEKFIHNLPFYGLAVICADDPVLRELVPKA-TEQVITYGGSGEDADYR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 251 ITSIKKNKKSTEFLLFINKNiidgigGNYKFKINLLGEHNILNATGAIIASLLAKVSIQKIQQSLLNFEGVKRRFSYLGN 330
Cdd:TIGR01082 241 AENIQQSGAEGKFSVRGKGK------LYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGVKRRFEILGE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 331 IQNAAIYDDYAHHPSEIKASYEIAKHLA-EKKIIVIFQPHRYSRTKYLFNDFINILQKINYLYIMDIYPAGEKPIKGV-N 408
Cdd:TIGR01082 315 FGGVLLIDDYAHHPTEIKATLKAARQGYpDKRIVVVFQPHRYSRTRDLFDDFAKVLSDADELILLDIYAAGEEPINGIdG 394
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1347645560 409 SKNLVNKIKNKNKNTFYLSNKDNLQHKLKPYFKKNNIIIFMGAGSITYYAENLI 462
Cdd:TIGR01082 395 KSLARKITQLGKIEPYFVPDLAELVEFLAAVLQSGDLILTMGAGDIIKLARELL 448
|
|
| PRK14573 |
PRK14573 |
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase; |
9-469 |
2.54e-74 |
|
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
Pssm-ID: 184752 [Multi-domain] Cd Length: 809 Bit Score: 249.35 E-value: 2.54e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 9 KIIIHFVGIGGIGMSGIAELMLDLGYNIQGSDINLSENIQRLKKKGIKFFKGHDKKNIKNITAVVFSSAIKKNNPELIEC 88
Cdd:PRK14573 4 SLFYHFIGIGGIGMSALAHILLDRGYSVSGSDLSEGKTVEKLKAKGARFFLGHQEEHVPEDAVVVYSSSISKDNVEYLSA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 89 KRLSIPLVSRADMLSELMKTKKSIAVAGSHGKTTTTSLVGSILDYAKFDPTIVNGGiINSYSKNNRFGLGEWMVVEADES 168
Cdd:PRK14573 84 KSRGNRLVHRAELLAELMQEQISILVSGSHGKTTVSSLITAIFQEAKKDPSYAIGG-LNQEGLNGYSGSSEYFVAEADES 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 169 DGTFLRLPHEINIITNLDIEHLDYYK-NKDNLIKAFKNFIN-----NLPFYgysilctdNNNLKRLSKEIKTrniITYSK 242
Cdd:PRK14573 163 DGSLKHYTPEFSVITNIDNEHLSNFEgDRELLLASIQDFARkvqqiNKCFY--------NGDCPRLKGCLQG---HSYGF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 243 NQkTSDVKITSIKKNKKSTEFLL-FINKNIIDgiggnykFKINLLGEHNILNATGAIIASLLAKVSIQKIQQSLLNFEGV 321
Cdd:PRK14573 232 SS-SCDLHILSYYQEGWRSYFSAkFLGVVYQD-------IELNLVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGV 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 322 KRRFSYLGNIQNAAIYDDYAHHPSEIKASYE-IAKHLAEKKIIVIFQPHRYSRTKYLFNDFINILQKINYLYIMDIYPAG 400
Cdd:PRK14573 304 QRRLERKNSSETFLFLEDYAHHPSEISCTLRaVRDAVGLRRIIAICQPHRFSRLRECLDSFPSAFQDADEVILTDVYSAG 383
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1347645560 401 EKPIKGVNSKNLVNKIKNKNKNTFYLSNKDNLQHKLKPYFKKNNIIIFMGAGSItYYAENLIKNNNAKK 469
Cdd:PRK14573 384 EEPEDSISYQKLAEAISQSSIVKCTYVPFHEIQRYLEQSIRVHDVCVSLGAGNI-YTLGEALKDFEPKK 451
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
112-366 |
1.90e-29 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 119.80 E-value: 1.90e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 112 IAVAGSHGKTTTTSLVGSILDYAKFdPTIVNGGIinsyskNNRFG-------------------LGE-------WMVVEA 165
Cdd:COG0769 83 IGVTGTNGKTTTTYLLAQILRALGK-KTGLIGTV------GNGIGgelipsslttpealdlqrlLAEmvdagvtHVVMEV 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 166 deS---------DGtflrLPHEINIITNLDIEHLDYYKNKDNLIKAFKNFINNLPFYGYSILCTDNNNLKRLSKEIKTRn 236
Cdd:COG0769 156 --SshaldqgrvDG----VRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLGPGGAAVINADDPYGRRLAAAAPAR- 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 237 IITYSKnQKTSDVKITSIKKNKKSTEFLLfinkniiDGIGGNYKFKINLLGEHNILNATGAIIASLLAKVSIQKIQQSLL 316
Cdd:COG0769 229 VITYGL-KADADLRATDIELSADGTRFTL-------VTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALE 300
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1347645560 317 NFEGVKRRFSYLGNIQNAAIYDDYAHHPSEIKASYEIAKHLAEKKIIVIF 366
Cdd:COG0769 301 KLKGVPGRMERVDGGQGPTVIVDYAHTPDALENVLEALRPHTKGRLIVVF 350
|
|
| mpl |
TIGR01081 |
UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase; Alternate name: ... |
72-368 |
8.68e-29 |
|
UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase; Alternate name: murein tripeptide ligase [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 130153 [Multi-domain] Cd Length: 448 Bit Score: 118.02 E-value: 8.68e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 72 VVFSSAIKKNNPELIECKRLSIPLVSRADMLSE-LMKTKKSIAVAGSHGKTTTTSLVGSILDYAKFDPTIVNGGIINSYS 150
Cdd:TIGR01081 64 VVIGNAMKRGNPCVEAVLNLNLPYTSGPQWLHDfVLHDRWVLAVAGTHGKTTTASMLAWVLEQCGLKPGFLIGGVPGNFG 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 151 KNNRFGLGEWMVVEADESDGTFL----RLPH---EINIITNLDIEHLDYYKNKDNLIKAFKNFINNLPFYGYsILCTDNN 223
Cdd:TIGR01081 144 VSARLGESPFFVIEADEYDTAFFdkrsKFVHyrpRTLVLNNLEFDHADIFDDLKAIQRQFHHLVRTVPGEGL-ILCPGRD 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 224 -NLKrlskeiKTRNIITYSKNQKT-SDVKITSIKKNKKSTEFLLFINKNIIDGIggnykfKINLLGEHNILNATGAIIAS 301
Cdd:TIGR01081 223 qSLK------DTLAKGCWSEQEFFgEQGEWQAEKITADGSHFDVLLDGEKVGEV------KWSLVGRHNMHNALMAIAAA 290
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1347645560 302 LLAKVSIQKIQQSLLNFEGVKRRFSYLGNIQNAAIYDDYAHHPSEIKASYE-IAKHLAEKKIIVIFQP 368
Cdd:TIGR01081 291 RHVGVAIEDACEALGSFVNAKRRLELKGEANGITVYDDFAHHPTAIEATLQgLRQKVGGARILAVLEP 358
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
114-300 |
1.98e-26 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 105.85 E-value: 1.98e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 114 VAGSHGKTTTTSLVGSILDYA-KFDPTIVNGGIINSYSKNNRFGL-----------GEWMVVEADESDGTFLRL----PH 177
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAgGVIGTIGTYIGKSGNTTNNAIGLpltlaemveagAEYAVLEVSSHGLGEGRLsgllKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 178 EINIITNLDIEHLDYYKNKDNLIKAFKNFINNLPFYGYSILCTDNNNLKRLSKEIKTRN--IITYSKNQKtSDVKITSIK 255
Cdd:pfam08245 81 DIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLKKAGvrVITYGIEGE-ADLRAANIE 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1347645560 256 KNKKSTEFLLFinkniiDGIGGNYKFKINLLGEHNILNATGAIIA 300
Cdd:pfam08245 160 LSSDGTSFDLF------TVPGGELEIEIPLLGRHNVYNALAAIAA 198
|
|
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
112-339 |
1.06e-24 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 105.95 E-value: 1.06e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 112 IAVAGSHGKTTTTSLVGSILdyAKFDPTIVNGGiinSYskNNRFGL----------GEWMVVEAdesdGTflRLPHEIN- 180
Cdd:COG0770 103 IAITGSNGKTTTKEMLAAVL--STKGKVLATPG---NF--NNEIGVpltllrlpedHEFAVLEM----GM--NHPGEIAy 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 181 ----------IITNLDIEHLDYYKNKDNLIKAFKNFINNLPFYGYSILCTDNNNLKRLSKEIKTRnIITYSKNQKtSDVK 250
Cdd:COG0770 170 lariarpdiaVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAKAR-VLTFGLSED-ADVR 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 251 ITSIKKNKKSTEFLLFINkniidgiGGNYKFKINLLGEHNILNATGAIIASLLAKVSIQKIQQSLLNFEGVKRRFSYLGN 330
Cdd:COG0770 248 AEDIELDEDGTRFTLHTP-------GGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIEG 320
|
....*....
gi 1347645560 331 IQNAAIYDD 339
Cdd:COG0770 321 AGGVTLIDD 329
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
61-339 |
2.00e-22 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 99.38 E-value: 2.00e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 61 HDKKNIKNITAVVFSSAIKKNNPELIECKRLSIPLVSraDMlsEL---MKTKKSIAVAGSHGKTTTTSLVGSILDYAKFD 137
Cdd:COG0771 58 HPEELLDGADLVVKSPGIPPDHPLLKAARAAGIPVIG--EI--ELayrLSPAPIIAITGTNGKTTTTTLIGHILKAAGLR 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 138 pTIVNGGIinsysknnrfGL-----------GEWMVVEAdeS----DGTF-LRlPHeINIITNLDIEHLDYYKNKDNLIK 201
Cdd:COG0771 134 -VAVGGNI----------GTplldlllepepPDVYVLEL--SsfqlETTPsLR-PD-VAVILNITPDHLDRHGSMEAYAA 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 202 AFKNFINNLPFYGYSILCTDNNNLKRLSKEIKTRnIITYSKNQK-TSDVKItsikknkkstefllfINKNIIDGIGGNYK 280
Cdd:COG0771 199 AKARIFANQTPDDYAVLNADDPLTRALAEEAKAR-VVPFSLKEPlEGGAGL---------------EDGKLVDRASGEEL 262
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1347645560 281 FKIN---LLGEHNILNATGAIIASLLAKVSIQKIQQSLLNFEGVKRRFSYLGNIQNAAIYDD 339
Cdd:COG0771 263 LPVDdlrLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEINGVRFIND 324
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
65-339 |
1.07e-19 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 91.25 E-value: 1.07e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 65 NIKNITAVVFSSAIKKNNPELIECKRLSIPLVSRADMLSELMKtKKSIAVAGSHGKTTTTSLVGSILDyAKFDPTIVNGG 144
Cdd:TIGR01087 59 DLNNADLVVKSPGIPPDHPLVQAAAKRGIPVVGDIELFLRLVP-LPVVAITGTNGKTTTTSLLYHLLK-AAGLKAFLGGN 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 145 IINSYSKNNRFGLGEWMVVEAdeSDGTFLRLPH---EINIITNLDIEHLDYYKNKDNLIKAFKNFINNLPFYGYSILCTD 221
Cdd:TIGR01087 137 IGTPALEVLDQEGAELYVLEL--SSFQLETTESlrpEIALILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNAD 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 222 NNNLKRLSKEIKtRNIITYSKnQKTSDVKItSIKKNKKSteflLFINKNIidgiggnykfkINLLGEHNILNATGAIIAS 301
Cdd:TIGR01087 215 DPRFARLAQKSK-AQVIWFSV-EKDAERGL-CIRDGGLY----LKPNDLE-----------GSLLGLHNAENILAAIALA 276
|
250 260 270
....*....|....*....|....*....|....*...
gi 1347645560 302 LLAKVSIQKIQQSLLNFEGVKRRFSYLGNIQNAAIYDD 339
Cdd:TIGR01087 277 KSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVHFYND 314
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
107-366 |
1.71e-19 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 90.84 E-value: 1.71e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 107 KTKKSIAVAGSHGKTTTTSLVGSILDYAK----FDPTIVN---GGIIN---------------SYSKNNRFGLGEWMVVE 164
Cdd:TIGR01085 83 KKLKVIGVTGTNGKTTTTSLIAQLLRLLGkktgLIGTIGYrlgGNDLIknpaalttpealtlqSTLAEMVEAGAQYAVME 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 165 ADE---SDGTFLRLPHEINIITNLDIEHLDYYKNKDNLIKAFKNFINNLPFYGYSILCTDN----NNLKRLSKEIKTrNI 237
Cdd:TIGR01085 163 VSShalAQGRVRGVRFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFAVINLDDeygaQFVKRLPKDITV-SA 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 238 ITYSKNQKTSDVKITSIkknkksTEFLLFINKNIIDGiGGNYKFKINLLGEHNILNATGAI-IASLLAKVSIQKIQQSLL 316
Cdd:TIGR01085 242 ITQPADGRAQDIKITDS------GYSFEGQQFTFETP-AGEGHLHTPLIGRFNVYNLLAALaTLLHLGGIDLEDIVAALE 314
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1347645560 317 NFEGVKRRFSYLGNIQNAAIYDDYAHHPSEIKASYEIAKHLAEKKIIVIF 366
Cdd:TIGR01085 315 KFRGVPGRMELVDGGQKFLVIVDYAHTPDALEKALRTLRKHKDGRLIVVF 364
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
72-339 |
1.52e-18 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 87.72 E-value: 1.52e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 72 VVFSSAIKKNNPELIECKRLSIPLVSRADMLSELMKTKKsIAVAGSHGKTTTTSLVGSILDYAkFDPTIVNGGI----IN 147
Cdd:PRK14106 72 VVVSPGVPLDSPPVVQAHKKGIEVIGEVELAYRFSKAPI-VAITGTNGKTTTTTLLGEIFKNA-GRKTLVAGNIgyplID 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 148 SYSKnnrfgLGEWMVVEADESD---GTFLRLPHEINIITNLDIEHLDYYKNKDNLIKAFKNFINNLPFYGYSILCTDNNN 224
Cdd:PRK14106 150 AVEE-----YGEDDIIVAEVSSfqlETIKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDPR 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 225 LKRLSKEIKTRnIITYSKNQKT------SDVKITsIKKNKKSTEfllfinknIIDgiggnyKFKINLLGEHNILNATGAI 298
Cdd:PRK14106 225 TRSLAKKAKAR-VIFFSRKSLLeegvfvKNGKIV-ISLGGKEEE--------VID------IDEIFIPGEHNLENALAAT 288
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1347645560 299 IASLLAKVSIQKIQQSLLNFEGVKRRFSYLGNIQNAAIYDD 339
Cdd:PRK14106 289 AAAYLLGISPDVIANTLKTFKGVEHRIEFVAEINGVKFIND 329
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
112-366 |
6.78e-18 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 85.95 E-value: 6.78e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 112 IAVAGSHGKTTTTSLVGSILDYAKFdPTIVNGGIinsyskNNRFGlGEwmVVEAD----ESDGTF--LR----------- 174
Cdd:PRK00139 98 IGVTGTNGKTTTAYLLAQILRLLGE-KTALIGTL------GNGIG-GE--LIPSGlttpDALDLQrlLAelvdagvtyaa 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 175 ---------------LPHEINIITNLDIEHLDYYKNKDNLIKAFKNFINNLpfYGYSILCTDNNNLKRLSKEIKTrniit 239
Cdd:PRK00139 168 mevsshaldqgrvdgLKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFSEL--GLAAVINADDEVGRRLLALPDA----- 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 240 YSKNQKTSDVKITSIKKNKKSTEFLLfinkniidgiggNYKFKINLLGEHNILNATGAIIASLLAKVSIQKIQQSLLNFE 319
Cdd:PRK00139 241 YAVSMAGADLRATDVEYTDSGQTFTL------------VTEVESPLIGRFNVSNLLAALAALLALGVPLEDALAALAKLQ 308
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1347645560 320 GVKRRFSYLGNIQNAAIYDDYAHHPSEIKASYEIAKHLAEKKIIVIF 366
Cdd:PRK00139 309 GVPGRMERVDAGQGPLVIVDYAHTPDALEKVLEALRPHAKGRLICVF 355
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
321-404 |
2.03e-14 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 68.52 E-value: 2.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 321 VKRRFSYLGNIQNAAIYDDYAHHPSEIKASYEIAKHLAEKKIIVIFQPHRySRTKYLFNDFINILQKIN-YLYIMDIYPA 399
Cdd:pfam02875 1 VPGRLEVVGENNGVLVIDDYAHNPDAMEAALRALRNLFPGRLILVFGGMG-DRDAEFHALLGRLAAALAdVVILTGDYPR 79
|
....*
gi 1347645560 400 GEKPI 404
Cdd:pfam02875 80 AEDPG 84
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
108-365 |
1.13e-13 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 73.58 E-value: 1.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 108 TKKSIAVAGSHGKTTTTSLVGSILdyAKFDPTivNGGIINSYSKNNRFGLGEwmvveadesdgTFLRL------------ 175
Cdd:PRK11929 602 SLPVVAITGSNGKTTTKEMIAAIL--AAWQGE--DRVLATEGNFNNEIGVPL-----------TLLRLraqhraavfelg 666
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 176 ---PHEIN-----------IITNLDIEHLDYYKNKDNLIKAFKNFINNLPFYGYSILCTDNNNLKRLSKEIKTRNIITYS 241
Cdd:PRK11929 667 mnhPGEIAylaaiaaptvaLVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKLAGARRVLRFG 746
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 242 KnQKTSDVKITSIKKNKKSTE-----FLLFINKNIIDgiggnykFKINLLGEHNILNATGAIIASLLAKVSIQKIQQSLL 316
Cdd:PRK11929 747 L-QPGADVYAEKIAKDISVGEaggtrCQVVTPAGSAE-------VYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLE 818
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1347645560 317 NFEGVKRRFSYLGNIQNAAIYDD-YAHHPSEIKASYEIAKHLA-EKKIIVI 365
Cdd:PRK11929 819 RFQPVAGRMQRRRLSCGTRIIDDtYNANPDSMRAAIDVLAELPnGPRALVL 869
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
86-366 |
5.10e-10 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 62.03 E-value: 5.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 86 IECKRLSIPLVSRADMLSEL---MKTKKS-----IAVAGSHGKTTTTSLVGSILDY------------AKFDPTIVNGgi 145
Cdd:PRK11929 81 AAADALVLPVADLRKALGELaarWYGRPSeqlslVAVTGTNGKTSCAQLLAQLLTRlgkpcgsigtlgARLDGRLIPG-- 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 146 inSYSKNNRFGLGE-----------WMVVEAdESDGTFL-RLPH---EINIITNLDIEHLDYYKNKDNLIKAFKNFINNL 210
Cdd:PRK11929 159 --SLTTPDAIILHRilarmraagadAVAMEA-SSHGLEQgRLDGlriAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKL 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 211 PFYGYSILCTDNNNLKRLSKEIKTRNIITYSKNQKTSDVKITSIKKNKKSTEFLLFINKniidgigGNYKFKINLLGEHN 290
Cdd:PRK11929 236 PGLGAAVINADDPAAARLLAALPRGLKVGYSPQNAGADVQARDLRATAHGQVFTLATPD-------GSYQLVTRLLGRFN 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 291 ILNATGAIIASLLAKVSIQKIQQSLLNFEGVKRRF---SYLGNIQNAAIYDDYAHHPSEIK---ASYEIAKHLAEKKIIV 364
Cdd:PRK11929 309 VSNLLLVAAALKKLGLPLAQIARALAAVSPVPGRMervGPTAGAQGPLVVVDYAHTPDALAkalTALRPVAQARNGRLVC 388
|
..
gi 1347645560 365 IF 366
Cdd:PRK11929 389 VF 390
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
12-110 |
1.70e-06 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 45.69 E-value: 1.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645560 12 IHFVGIGGIGMSGIAELMLDLGYNIQGSDInlsenIQRLKKkgikffkghdkkniKNITAVVFSSA---IKKNNPELIEC 88
Cdd:pfam01225 2 IHFVGIDGRGMSPGALFLALKGYRVDGSDF-----IESLIA--------------LGAAAVVGHDAannISPDNPELEAA 62
|
90 100
....*....|....*....|..
gi 1347645560 89 KRLSIPLVSRADMLSELMKTKK 110
Cdd:pfam01225 63 KVPGIPVIDRREALAELAAAFY 84
|
|
| |
