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Conserved domains on  [gi|1347645558|gb|PPR55463|]
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D-alanine--D-alanine ligase B [Alphaproteobacteria bacterium MarineAlpha5_Bin1]

Protein Classification

D-alanine--D-alanine ligase( domain architecture ID 1000119)

D-alanine--D-alanine ligase catalyzes the synthesis of D-alanyl-D-alanine, an essential component of bacterial peptidoglycan, and is involved in cell wall formation

EC:  6.3.2.4
Gene Ontology:  GO:0009252|GO:0008716|GO:0046872|GO:0005524
SCOP:  4002041|4003870

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DdlA COG1181
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, ...
 12-321 1.69e-98

D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, General function prediction only]; D-alanine-D-alanine ligase or related ATP-grasp enzyme is part of the Pathway/BioSystem: Mureine biosynthesis


:

Pssm-ID: 440794 [Multi-domain]  Cd Length: 303  Bit Score: 292.40  E-value: 1.69e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  12 KILILEGGFNEEHEISLNTAKEIKRSLTNLNISFDSLLVKPQTFSEDINHYNNDyLCFNALHGTFGEDGTIQKILENKKI 91
Cdd:COG1181     2 RVAVLFGGRSAEREVSLKSGRAVAAALDKAGYDVVPIGIDVEDLPAALKELKPD-VVFPALHGRGGEDGTIQGLLELLGI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  92 RYTHSDSITSNIGFNKFLTKKKIQNTKILTAESFLLKATNLDEIkiREIFEQFNS-FVVKPVSSGSSYGVQIIKDSKDLE 170
Cdd:COG1181    81 PYTGSGVLASALAMDKALTKRVLAAAGLPTPPYVVLRRGELADL--EAIEEELGLpLFVKPAREGSSVGVSKVKNAEELA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 171 NFVRNIennhniYKKHNELLIERYIAGRELTVAVVNKENIsEAVEVTEIISNNYFYDYQSKYSKGFSRHILPAKLPVKIY 250
Cdd:COG1181   159 AALEEA------FKYDDKVLVEEFIDGREVTVGVLGNGGP-RALPPIEIVPENGFYDYEAKYTDGGTEYICPARLPEELE 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1347645558 251 DNCLKYAKIVHDTIKCRNLSRSDFLYDNKN-IYFLEINTQPGLTSISLVPEQLKHKNISFDNLIQNIINSSL 321
Cdd:COG1181   232 ERIQELALKAFRALGCRGYARVDFRLDEDGePYLLEVNTLPGMTPTSLLPKAAAAAGISYEELIERIIELAL 303
 
Name Accession Description Interval E-value
DdlA COG1181
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, ...
 12-321 1.69e-98

D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, General function prediction only]; D-alanine-D-alanine ligase or related ATP-grasp enzyme is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440794 [Multi-domain]  Cd Length: 303  Bit Score: 292.40  E-value: 1.69e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  12 KILILEGGFNEEHEISLNTAKEIKRSLTNLNISFDSLLVKPQTFSEDINHYNNDyLCFNALHGTFGEDGTIQKILENKKI 91
Cdd:COG1181     2 RVAVLFGGRSAEREVSLKSGRAVAAALDKAGYDVVPIGIDVEDLPAALKELKPD-VVFPALHGRGGEDGTIQGLLELLGI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  92 RYTHSDSITSNIGFNKFLTKKKIQNTKILTAESFLLKATNLDEIkiREIFEQFNS-FVVKPVSSGSSYGVQIIKDSKDLE 170
Cdd:COG1181    81 PYTGSGVLASALAMDKALTKRVLAAAGLPTPPYVVLRRGELADL--EAIEEELGLpLFVKPAREGSSVGVSKVKNAEELA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 171 NFVRNIennhniYKKHNELLIERYIAGRELTVAVVNKENIsEAVEVTEIISNNYFYDYQSKYSKGFSRHILPAKLPVKIY 250
Cdd:COG1181   159 AALEEA------FKYDDKVLVEEFIDGREVTVGVLGNGGP-RALPPIEIVPENGFYDYEAKYTDGGTEYICPARLPEELE 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1347645558 251 DNCLKYAKIVHDTIKCRNLSRSDFLYDNKN-IYFLEINTQPGLTSISLVPEQLKHKNISFDNLIQNIINSSL 321
Cdd:COG1181   232 ERIQELALKAFRALGCRGYARVDFRLDEDGePYLLEVNTLPGMTPTSLLPKAAAAAGISYEELIERIIELAL 303
ddl PRK01372
D-alanine--D-alanine ligase; Reviewed
 10-321 6.53e-92

D-alanine--D-alanine ligase; Reviewed


Pssm-ID: 234948 [Multi-domain]  Cd Length: 304  Bit Score: 275.84  E-value: 6.53e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  10 MEKILILEGGFNEEHEISLNTAKEIKRSLTNLNI---SFDSLLVKPQTFSE---DInhynndylCFNALHGTFGEDGTIQ 83
Cdd:PRK01372    4 FGKVAVLMGGTSAEREVSLNSGAAVLAALREAGYdahPIDPGEDIAAQLKElgfDR--------VFNALHGRGGEDGTIQ 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  84 KILENKKIRYTHSDSITSNIGFNKFLTKKKIQNTKILTAESFLLKATNLDEIKIREI-FEqfnsFVVKPVSSGSSYGVQI 162
Cdd:PRK01372   76 GLLELLGIPYTGSGVLASALAMDKLRTKLVWQAAGLPTPPWIVLTREEDLLAAIDKLgLP----LVVKPAREGSSVGVSK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 163 IKDSKDLENFVRNIEnnhniykKH-NELLIERYIAGRELTVAVVNkeniSEAVEVTEIISNNYFYDYQSKYSKGFSRHIL 241
Cdd:PRK01372  152 VKEEDELQAALELAF-------KYdDEVLVEKYIKGRELTVAVLG----GKALPVIEIVPAGEFYDYEAKYLAGGTQYIC 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 242 PAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYDNKNI-YFLEINTQPGLTSISLVPEQLKHKNISFDNLIQNIINSS 320
Cdd:PRK01372  221 PAGLPAEIEAELQELALKAYRALGCRGWGRVDFMLDEDGKpYLLEVNTQPGMTSHSLVPMAARAAGISFSELVDRILEDA 300


                  .
gi 1347645558 321 L 321
Cdd:PRK01372  301 L 301
D_ala_D_alaTIGR TIGR01205
D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a ...
 12-317 2.73e-74

D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a required precursor of the bacterial cell wall. It also describes some closely related proteins responsible for resistance to glycopeptide antibiotics such as vancomycin. The mechanism of glyopeptide antibiotic resistance involves the production of D-alanine-D-lactate (VanA and VanB families) or D-alanine-D-serine (VanC). The seed alignment contains only chromosomally encoded D-ala--D-ala ligases, but a number of antibiotic resistance proteins score above the trusted cutoff of this model. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273498 [Multi-domain]  Cd Length: 315  Bit Score: 231.02  E-value: 2.73e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  12 KILILEGGFNEEHEISLNTAKEIKRSLTNLNISFDSLLVKPQT--FSEDINHYNNDY--------LCFNALHGTFGEDGT 81
Cdd:TIGR01205   1 RVAVLFGGKSAEHEISLVSAAAVLKALRDLGYDVYPVDIDKMGswTYKDLPQLILELgallegidVVFPVLHGRYGEDGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  82 IQKILENKKIRYTHSDSITSNIGFNKFLTKKKIQNTKILTAESFLLK--ATNLDEIKIREIFEQFN-SFVVKPVSSGSSY 158
Cdd:TIGR01205  81 IQGLLELMGIPYTGSGVLASALSMDKLLTKLLWKALGLPTPDYIVLTqnRASADELECEQVAEPLGfPVIVKPAREGSSV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 159 GVQIIKDSKDLENFVRniennhNIYKKHNELLIERYIAGRELTVAVVNKENISEAVEVTEIIsnNYFYDYQSKYSKGFSR 238
Cdd:TIGR01205 161 GVSKVKSEEELQAALD------EAFEYDEEVLVEQFIKGRELEVSILGNEEALPIIEIVPEI--EGFYDYEAKYLDGSTE 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 239 HILPAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYD-NKNIYFLEINTQPGLTSISLVPEQLKHKNISFDNLIQNII 317
Cdd:TIGR01205 233 YVIPAPLDEELEEKIKELALKAYKALGCRGLARVDFFLDeEGEIYLNEINTIPGMTAISLFPKAAAAAGIEFSQLVERIL 312
Dala_Dala_lig_C pfam07478
D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the ...
 148-317 4.22e-39

D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF).


Pssm-ID: 429483 [Multi-domain]  Cd Length: 204  Bit Score: 136.68  E-value: 4.22e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 148 VVKPVSSGSSYGVQIIKDSKDLENFVRNIennhniYKKHNELLIERYIAGRELTVAVVNKENIsEAVEVTEIISNNYFYD 227
Cdd:pfam07478  40 FVKPARLGSSVGVSKVESREELQAAIEEA------FQYDEKVLVEEGIEGREIECAVLGNEDP-EVSPVGEIVPSGGFYD 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 228 YQSKYSKGFSRHILPAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYDNK-NIYFLEINTQPGLTSISLVPEQLKHKN 306
Cdd:pfam07478 113 YEAKYIDDSAQIVVPADLEEEQEEQIQELALKAYKALGCRGLARVDFFLTEDgEIVLNEVNTIPGFTSISMFPKLAAAAG 192

                         170
                  ....*....|.
gi 1347645558 307 ISFDNLIQNII 317
Cdd:pfam07478 193 VSFPDLVDQLI 203
 
Name Accession Description Interval E-value
DdlA COG1181
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, ...
 12-321 1.69e-98

D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, General function prediction only]; D-alanine-D-alanine ligase or related ATP-grasp enzyme is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440794 [Multi-domain]  Cd Length: 303  Bit Score: 292.40  E-value: 1.69e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  12 KILILEGGFNEEHEISLNTAKEIKRSLTNLNISFDSLLVKPQTFSEDINHYNNDyLCFNALHGTFGEDGTIQKILENKKI 91
Cdd:COG1181     2 RVAVLFGGRSAEREVSLKSGRAVAAALDKAGYDVVPIGIDVEDLPAALKELKPD-VVFPALHGRGGEDGTIQGLLELLGI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  92 RYTHSDSITSNIGFNKFLTKKKIQNTKILTAESFLLKATNLDEIkiREIFEQFNS-FVVKPVSSGSSYGVQIIKDSKDLE 170
Cdd:COG1181    81 PYTGSGVLASALAMDKALTKRVLAAAGLPTPPYVVLRRGELADL--EAIEEELGLpLFVKPAREGSSVGVSKVKNAEELA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 171 NFVRNIennhniYKKHNELLIERYIAGRELTVAVVNKENIsEAVEVTEIISNNYFYDYQSKYSKGFSRHILPAKLPVKIY 250
Cdd:COG1181   159 AALEEA------FKYDDKVLVEEFIDGREVTVGVLGNGGP-RALPPIEIVPENGFYDYEAKYTDGGTEYICPARLPEELE 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1347645558 251 DNCLKYAKIVHDTIKCRNLSRSDFLYDNKN-IYFLEINTQPGLTSISLVPEQLKHKNISFDNLIQNIINSSL 321
Cdd:COG1181   232 ERIQELALKAFRALGCRGYARVDFRLDEDGePYLLEVNTLPGMTPTSLLPKAAAAAGISYEELIERIIELAL 303
ddl PRK01372
D-alanine--D-alanine ligase; Reviewed
 10-321 6.53e-92

D-alanine--D-alanine ligase; Reviewed


Pssm-ID: 234948 [Multi-domain]  Cd Length: 304  Bit Score: 275.84  E-value: 6.53e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  10 MEKILILEGGFNEEHEISLNTAKEIKRSLTNLNI---SFDSLLVKPQTFSE---DInhynndylCFNALHGTFGEDGTIQ 83
Cdd:PRK01372    4 FGKVAVLMGGTSAEREVSLNSGAAVLAALREAGYdahPIDPGEDIAAQLKElgfDR--------VFNALHGRGGEDGTIQ 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  84 KILENKKIRYTHSDSITSNIGFNKFLTKKKIQNTKILTAESFLLKATNLDEIKIREI-FEqfnsFVVKPVSSGSSYGVQI 162
Cdd:PRK01372   76 GLLELLGIPYTGSGVLASALAMDKLRTKLVWQAAGLPTPPWIVLTREEDLLAAIDKLgLP----LVVKPAREGSSVGVSK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 163 IKDSKDLENFVRNIEnnhniykKH-NELLIERYIAGRELTVAVVNkeniSEAVEVTEIISNNYFYDYQSKYSKGFSRHIL 241
Cdd:PRK01372  152 VKEEDELQAALELAF-------KYdDEVLVEKYIKGRELTVAVLG----GKALPVIEIVPAGEFYDYEAKYLAGGTQYIC 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 242 PAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYDNKNI-YFLEINTQPGLTSISLVPEQLKHKNISFDNLIQNIINSS 320
Cdd:PRK01372  221 PAGLPAEIEAELQELALKAYRALGCRGWGRVDFMLDEDGKpYLLEVNTQPGMTSHSLVPMAARAAGISFSELVDRILEDA 300


                  .
gi 1347645558 321 L 321
Cdd:PRK01372  301 L 301
D_ala_D_alaTIGR TIGR01205
D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a ...
 12-317 2.73e-74

D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a required precursor of the bacterial cell wall. It also describes some closely related proteins responsible for resistance to glycopeptide antibiotics such as vancomycin. The mechanism of glyopeptide antibiotic resistance involves the production of D-alanine-D-lactate (VanA and VanB families) or D-alanine-D-serine (VanC). The seed alignment contains only chromosomally encoded D-ala--D-ala ligases, but a number of antibiotic resistance proteins score above the trusted cutoff of this model. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273498 [Multi-domain]  Cd Length: 315  Bit Score: 231.02  E-value: 2.73e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  12 KILILEGGFNEEHEISLNTAKEIKRSLTNLNISFDSLLVKPQT--FSEDINHYNNDY--------LCFNALHGTFGEDGT 81
Cdd:TIGR01205   1 RVAVLFGGKSAEHEISLVSAAAVLKALRDLGYDVYPVDIDKMGswTYKDLPQLILELgallegidVVFPVLHGRYGEDGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  82 IQKILENKKIRYTHSDSITSNIGFNKFLTKKKIQNTKILTAESFLLK--ATNLDEIKIREIFEQFN-SFVVKPVSSGSSY 158
Cdd:TIGR01205  81 IQGLLELMGIPYTGSGVLASALSMDKLLTKLLWKALGLPTPDYIVLTqnRASADELECEQVAEPLGfPVIVKPAREGSSV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 159 GVQIIKDSKDLENFVRniennhNIYKKHNELLIERYIAGRELTVAVVNKENISEAVEVTEIIsnNYFYDYQSKYSKGFSR 238
Cdd:TIGR01205 161 GVSKVKSEEELQAALD------EAFEYDEEVLVEQFIKGRELEVSILGNEEALPIIEIVPEI--EGFYDYEAKYLDGSTE 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 239 HILPAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYD-NKNIYFLEINTQPGLTSISLVPEQLKHKNISFDNLIQNII 317
Cdd:TIGR01205 233 YVIPAPLDEELEEKIKELALKAYKALGCRGLARVDFFLDeEGEIYLNEINTIPGMTAISLFPKAAAAAGIEFSQLVERIL 312
ddl PRK01966
D-alanine--D-alanine ligase;
10-321 3.35e-63

D-alanine--D-alanine ligase;


Pssm-ID: 234993 [Multi-domain]  Cd Length: 333  Bit Score: 203.04  E-value: 3.35e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  10 MEKILILEGGFNEEHEISLNTAKEIKRSL---------------------TNLNISFDSLLVKPQTFSEDIN----HYNN 64
Cdd:PRK01966    3 KMRVALLFGGRSAEHEVSLVSAKSVLKALdkekyevvpigitkdgrwyliDADNMELADDDNDKEDLSLLILpsggSEEV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  65 DYLcFNALHGTFGEDGTIQKILENKKIRYTHSDSITSNIGFNKFLTKKKIQNTKILTAESFLLKATNLDEIKIREIFEQF 144
Cdd:PRK01966   83 DVV-FPVLHGPPGEDGTIQGLLELLGIPYVGCGVLASALSMDKILTKRLLAAAGIPVAPYVVLTRGDWEEASLAEIEAKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 145 N-SFVVKPVSSGSSYGVQIIKDSKDLEN-----FvrniennhniykKH-NELLIERYIAGRELTVAVVnkENISEAVEVT 217
Cdd:PRK01966  162 GlPVFVKPANLGSSVGISKVKNEEELAAaldlaF------------EYdRKVLVEQGIKGREIECAVL--GNDPKASVPG 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 218 EIISNNYFYDYQSKYSKGFSRHILPAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYDNKN-IYFLEINTQPGLTSIS 296
Cdd:PRK01966  228 EIVKPDDFYDYEAKYLDGSAELIIPADLSEELTEKIRELAIKAFKALGCSGLARVDFFLTEDGeIYLNEINTMPGFTPIS 307

                         330       340
                  ....*....|....*....|....*
gi 1347645558 297 LVPEQLKHKNISFDNLIQNIINSSL 321
Cdd:PRK01966  308 MYPKLWEASGLSYPELIDRLIELAL 332
PRK14571 PRK14571
D-alanyl-alanine synthetase A; Provisional
 12-320 1.81e-58

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 184751 [Multi-domain]  Cd Length: 299  Bit Score: 190.03  E-value: 1.81e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  12 KILILEGGFNEEHEISLNTAKEIKRSLTNLNISFDSLLVKpQTFSEDINHYNNDYLCFNALHGTFGEDGTIQKILENKKI 91
Cdd:PRK14571    2 RVALLMGGVSREREISLRSGERVKKALEKLGYEVTVFDVD-EDFLKKVDQLKSFDVVFNVLHGTFGEDGTLQAILDFLGI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  92 RYTHSDSITSNIGFNKFLTKKKIQNTkiltaesflLKATNLDEIKIREIFEQFN-SFVVKPVSSGSSYGVQIIKDSKDLE 170
Cdd:PRK14571   81 RYTGSDAFSSMICFDKLLTYRFLKGT---------VEIPDFVEIKEFMKTSPLGyPCVVKPRREGSSIGVFICESDEEFQ 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 171 NFVRniennhNIYKKHNELLIERYIAGRELTVAVVNKENISEAVEVTEIISNNYFYDYQSKYSKGFSRHILPAKLPVKIY 250
Cdd:PRK14571  152 HALK------EDLPRYGSVIVQEYIPGREMTVSILETEKGFEVLPILELRPKRRFYDYVAKYTKGETEFILPAPLNPEEE 225

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 251 DNCLKYAKIVHDTIKCRNLSRSDFLYDNKNIYFLEINTQPGLTSISLVPEQLKHKNISFDNLIQNIINSS 320
Cdd:PRK14571  226 RLVKETALKAFVEAGCRGFGRVDGIFSDGRFYFLEINTVPGLTELSDLPASAKAGGIEFEELVDIIIKSA 295
PRK14569 PRK14569
D-alanyl-alanine synthetase A; Provisional
 11-320 1.55e-40

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 173033 [Multi-domain]  Cd Length: 296  Bit Score: 143.28  E-value: 1.55e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  11 EKILILEGGFNEEHEISLNTAKEIKRSLTN-------LNISFDSLLVKPQTFSEDinhynndyLCFNALHGTFGEDGTIQ 83
Cdd:PRK14569    4 EKIVVLYGGDSPEREVSLKSGKAVLDSLISqgydavgVDASGKELVAKLLELKPD--------KCFVALHGEDGENGRVS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  84 KILENKKIRYTHSDSITSNIGFNKFLTKKKIQNTKILTAESFLL--KATNLDEIKIreifeqfnSFVVKPVSSGSSYGVQ 161
Cdd:PRK14569   76 ALLEMLEIKHTSSSMKSSVITMDKMISKEILMHHRMPTPMAKFLtdKLVAEDEISF--------PVAVKPSSGGSSIATF 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 162 IIKDSKDLENFVRNIEnnhniykKHNELLIERYIAGRELTVAVVNKENISEavevTEIISNNYFYDYQSKYSkGFSRHIL 241
Cdd:PRK14569  148 KVKSIQELKHAYEEAS-------KYGEVMIEQWVTGKEITVAIVNDEVYSS----VWIEPQNEFYDYESKYS-GKSIYHS 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 242 PAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYDNK-NIYFLEINTQPGLTSISLVPEQLKHKNISFDNLIQNIINSS 320
Cdd:PRK14569  216 PSGLCEQKELEVRQLAKKAYDLLGCSGHARVDFIYDDRgNFYIMEINSSPGMTDNSLSPKSAAAEGVDFDSFVKRIIEQA 295
Dala_Dala_lig_C pfam07478
D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the ...
 148-317 4.22e-39

D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF).


Pssm-ID: 429483 [Multi-domain]  Cd Length: 204  Bit Score: 136.68  E-value: 4.22e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 148 VVKPVSSGSSYGVQIIKDSKDLENFVRNIennhniYKKHNELLIERYIAGRELTVAVVNKENIsEAVEVTEIISNNYFYD 227
Cdd:pfam07478  40 FVKPARLGSSVGVSKVESREELQAAIEEA------FQYDEKVLVEEGIEGREIECAVLGNEDP-EVSPVGEIVPSGGFYD 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 228 YQSKYSKGFSRHILPAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYDNK-NIYFLEINTQPGLTSISLVPEQLKHKN 306
Cdd:pfam07478 113 YEAKYIDDSAQIVVPADLEEEQEEQIQELALKAYKALGCRGLARVDFFLTEDgEIVLNEVNTIPGFTSISMFPKLAAAAG 192

                         170
                  ....*....|.
gi 1347645558 307 ISFDNLIQNII 317
Cdd:pfam07478 193 VSFPDLVDQLI 203
PRK14572 PRK14572
D-alanyl-alanine synthetase A; Provisional
 10-321 5.07e-34

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 173036 [Multi-domain]  Cd Length: 347  Bit Score: 127.33  E-value: 5.07e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  10 MEKILILEGGFNEEHEISLNTAKEIKRSLTNLNISFDSLLVKPQ----------------------TFSEDINHYNN--- 64
Cdd:PRK14572    1 MAKIAVFFGGSSTEHSISIRTGCFICATLHTMGHSVKPILLTPDggwvvptvyrpsipdesgnsedLFLEEFQKANGvse 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  65 -------DYL-CFNALHGTFGEDGTIQKILENKKIRYTHSDSITSNIGFNKFLTKKKIQNTKILTAESF---LLKATNLD 133
Cdd:PRK14572   81 padisqlDADiAFLGLHGGAGEDGRIQGFLDTLGIPYTGSGVLASALAMDKTRANQIFLQSGQKVAPFFeleKLKYLNSP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 134 EIKIREI----FEQFnsfvVKPVSSGSSYGVQIIKDSKDLENFVrniennHNIYKKHNELLIERYIAGRELTVAVV---- 205
Cdd:PRK14572  161 RKTLLKLeslgFPQF----LKPVEGGSSVSTYKITNAEQLMTLL------ALIFESDSKVMSQSFLSGTEVSCGVLeryr 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 206 NKENISEAVEVTEIISNNYFYDYQSKYSKGFSRHILPAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYDNKNIYFLE 285
Cdd:PRK14572  231 GGKRNPIALPATEIVPGGEFFDFESKYKQGGSEEITPARISDQEMKRVQELAIRAHESLGCKGYSRTDFIIVDGEPHILE 310

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1347645558 286 INTQPGLTSISLVPEQLKHKNISFDNLIQNIINSSL 321
Cdd:PRK14572  311 TNTLPGMTETSLIPQQAKAAGINMEEVFTDLIEIGL 346
PRK14570 PRK14570
D-alanyl-alanine synthetase A; Provisional
 10-318 1.25e-22

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 173034 [Multi-domain]  Cd Length: 364  Bit Score: 96.44  E-value: 1.25e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  10 MEKILIL-EGGFNEEHEISLNTAKEIKRSLTNLN----------------ISFDSLLVKPQTFSEDIN-----------H 61
Cdd:PRK14570    1 MKKNLMLiFGGVSFEHEISLRSAYGIYSALLKLDkyniysvfidkctgiwYLLDSVPDPPKLIKRDVLpivslipgcgiF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  62 YNNDYL----CFNALHGTFGEDGTIQKILENKKIRYTHSDSITSNIGFNKFLTKKKIQNTKILTAESFLLKATN--LDEI 135
Cdd:PRK14570   81 VNNKNLeidvVFPIVHGRTGEDGAIQGFLKVMDIPCVGAGILGSAISINKYFCKLLLKSFNIPLVPFIGFRKYDyfLDKE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 136 KIREIFEQFNSF--VVKPVSSGSSYGVQIIKDSKDLENFVRNIennhniYKKHNELLIERYIAGRELTVAVVNKENISEA 213
Cdd:PRK14570  161 GIKKDIKEVLGYpvIVKPAVLGSSIGINVAYNENQIEKCIEEA------FKYDLTVVIEKFIEAREIECSVIGNEQIKIF 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 214 VEVTEIISNNYFYDYQSKYSKGFSRHI---LPAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYDNKN--IYFLEINT 288
Cdd:PRK14570  235 TPGEIVVQDFIFYDYDAKYSTIPGNSIvfnIPAHLDTKHLLDIKEYAFLTYKNLELRGMARIDFLIEKDTglIYLNEINT 314

                         330       340       350
                  ....*....|....*....|....*....|
gi 1347645558 289 QPGLTSISLVPEQLKHKNISFDNLIQNIIN 318
Cdd:PRK14570  315 IPGFTDISMFAKMCEHDGLQYKSLVDNLID 344
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 106-304 2.91e-19

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 85.31  E-value: 2.91e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 106 NKFLTKKKIQNTKILTAESFLLkaTNLDEIkiREIFEQFNS-FVVKPVSSGSSYGVQIIKDSKDLENFVRNIENNHNIYK 184
Cdd:COG0439    54 DKVLMREALAAAGVPVPGFALV--DSPEEA--LAFAEEIGYpVVVKPADGAGSRGVRVVRDEEELEAALAEARAEAKAGS 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 185 KHNELLIERYIAGRELTV-AVVNKENIsEAVEVTE-IISNNYFYDYqskyskgfsRHILPAKLPVKIYDNCLKYAKIVHD 262
Cdd:COG0439   130 PNGEVLVEEFLEGREYSVeGLVRDGEV-VVCSITRkHQKPPYFVEL---------GHEAPSPLPEELRAEIGELVARALR 199

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1347645558 263 TIK-CRNLSRSDFLYD-NKNIYFLEINTQPG----------LTSISLVPEQLKH 304
Cdd:COG0439   200 ALGyRRGAFHTEFLLTpDGEPYLIEINARLGgehippltelATGVDLVREQIRL 253
PRK14573 PRK14573
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
18-321 1.55e-13

bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;


Pssm-ID: 184752 [Multi-domain]  Cd Length: 809  Bit Score: 71.39  E-value: 1.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  18 GGFNEEHEISLNTAKEIKRSLTN-------LNISFDSLLVKPQTFSEDINHYNNDYL--------------CFNALHGTF 76
Cdd:PRK14573  459 GGKSCEHDISLLSAKNIAKYLSPefydvsyFLINRQGLWETVSSLETAIEEDSGKSVlsseiaqalakvdvVLPILHGPF 538

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  77 GEDGTIQKILENKKIRYTHSDSITSNIGFNKFLTKKKIQNTKI--LTAESFLLKATNLD-EIKIREIFEQFnSF--VVKP 151
Cdd:PRK14573  539 GEDGTMQGFLEIIGKPYTGPSLAFSAIAMDKVLTKRFASDVGVpvVPYQPLTLAGWKREpELCLAHIVEAF-SFpmFVKT 617

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 152 VSSGSSYGVQIIKDSKDL-----ENFVRNiennhniykkhNELLIERYIAG-RELTVAVVNKENISEAV-EVTEIISNNY 224
Cdd:PRK14573  618 AHLGSSIGVFEVHNVEELrdkisEAFLYD-----------TDVFVEESRLGsREIEVSCLGDGSSAYVIaGPHERRGSGG 686

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 225 FYDYQSKYskGFS-----RHILPAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYDNKNIYFL-EINTQPGLTSISLV 298
Cdd:PRK14573  687 FIDYQEKY--GLSgkssaQIVFDLDLSKESQEQVLELAERIYRLLQGKGSCRIDFFLDEEGNFWLsEMNPIPGMTEASPF 764

                         330       340
                  ....*....|....*....|...
gi 1347645558 299 PEQLKHKNISFDNLIQNIINSSL 321
Cdd:PRK14573  765 LTAFVRKGWTYEQIVHQLIIDGL 787
Dala_Dala_lig_N pfam01820
D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the ...
 12-94 1.18e-11

D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4 which is thought to be involved in substrate binding. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF). This domain is structurally related to the PreATP-grasp domain.


Pssm-ID: 460346 [Multi-domain]  Cd Length: 118  Bit Score: 60.70  E-value: 1.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558  12 KILILEGGFNEEHEISLNTAKEIKRSL-----------------------TNLNISFDSLLVKPQTFSEDINHY----NN 64
Cdd:pfam01820   1 KVAVLFGGRSSEHEVSLVSARSVLKALdkekyevipigitkdgrlgeaalRELASDDGLLLEVDDAPDGGPAGLlfgpNV 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1347645558  65 DYLC------FNALHGTFGEDGTIQKILENKKIRYT 94
Cdd:pfam01820  81 LELLievdvvFPVLHGPNGEDGTLQGLLELAGIPYV 116
LysX COG0189
Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport ...
 137-292 4.38e-08

Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport and metabolism, Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis, Secondary metabolites biosynthesis, transport and catabolism]; Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 439959 [Multi-domain]  Cd Length: 289  Bit Score: 53.41  E-value: 4.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 137 IREIFEQFN-SFVVKPVSSGSSYGVQIIKDSKDLENFVRNIENNHniykkHNELLIERYIA---GRELTVAVVNKenisE 212
Cdd:COG0189   123 LRAFLEELGgPVVLKPLDGSGGRGVFLVEDEDALESILEALTELG-----SEPVLVQEFIPeedGRDIRVLVVGG----E 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 213 AVEVTEIISNNyfYDYQSKYSKGFSrhILPAKLPVKIYDNCLKYAKIVHDtikcrNLSRSDFLYDNKNIYFLEINTQPGL 292
Cdd:COG0189   194 PVAAIRRIPAE--GEFRTNLARGGR--AEPVELTDEERELALRAAPALGL-----DFAGVDLIEDDDGPLVLEVNVTPGF 264
PRK12767 PRK12767
carbamoyl phosphate synthase-like protein; Provisional
 103-287 8.33e-06

carbamoyl phosphate synthase-like protein; Provisional


Pssm-ID: 237195 [Multi-domain]  Cd Length: 326  Bit Score: 46.80  E-value: 8.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 103 IGFNKFLTKKKIQNTKILTAESFLLkaTNLDEIKIREIFEQFN-SFVVKPVSSGSSYGVQIIKDSKDLENFvrniennhn 181
Cdd:PRK12767  108 ICNDKWLTYEFLKENGIPTPKSYLP--ESLEDFKAALAKGELQfPLFVKPRDGSASIGVFKVNDKEELEFL--------- 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 182 iYKKHNELLIERYIAGRELTVAVV---NKENISE-AVEVTEIISNNyfydyqskYSKGFSRhilpaklpvkiydnclKYA 257
Cdd:PRK12767  177 -LEYVPNLIIQEFIEGQEYTVDVLcdlNGEVISIvPRKRIEVRAGE--------TSKGVTV----------------KDP 231

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1347645558 258 KIVHDTIKCRNLSRS------DFLYDNKNIYFLEIN 287
Cdd:PRK12767  232 ELFKLAERLAEALGArgplniQCFVTDGEPYLFEIN 267
ATP-grasp_4 pfam13535
ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent ...
 147-202 5.44e-04

ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 316093 [Multi-domain]  Cd Length: 160  Bit Score: 39.96  E-value: 5.44e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1347645558 147 FVVKPVSSGSSYGVQIIKDSKDLENFVRNIENN----HNIYKKH----NELLIERYIAGRELTV 202
Cdd:pfam13535   5 CVIKPSVGFFSVGVYKINNREEWKAAFAAIREEieqwKEMYPEAvvdgGSFLVEEYIEGEEFAV 68
PRK08654 PRK08654
acetyl-CoA carboxylase biotin carboxylase subunit;
273-303 8.98e-03

acetyl-CoA carboxylase biotin carboxylase subunit;


Pssm-ID: 236325 [Multi-domain]  Cd Length: 499  Bit Score: 37.66  E-value: 8.98e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1347645558 273 DFLYDNKNIYFLEINTQ--------PGLTSISLVPEQLK 303
Cdd:PRK08654  275 EFLYSNGNFYFLEMNTRlqvehpitEMVTGIDIVKEQIK 313
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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