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Conserved domains on  [gi|1325451164|gb|PMC40824|]
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Na(+)/H(+) antiporter subunit B [Bacillus sp. UMB0899]

Protein Classification

Na(+)/H(+) antiporter subunit B( domain architecture ID 10014008)

Na(+)/H(+) antiporter subunit B is a component of the Mrp complex, a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK12573 PRK12573
Na(+)/H(+) antiporter subunit B;
1-140 1.72e-54

Na(+)/H(+) antiporter subunit B;


:

Pssm-ID: 183602 [Multi-domain]  Cd Length: 140  Bit Score: 167.37  E-value: 1.72e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164   1 MKTNDIIFQTATKVVVFIIILYSLHLFFSGHYTPGGGFIGGLMTAGALVLLLLAFDIKTVVNIIQVDYIKLIAVGLLFAV 80
Cdd:PRK12573    1 MKMNDLILRTVAKIVTFIILLFSVFLFLAGHNEPGGGFIGGLITASALVILLLAFDIKTVRRALPFDFKILAGIGLLFAI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164  81 LTGIGSFFFKVPFLTHTFSYVDLPFLGETALATAVLFDLGVYLVVIGVTMTIIQTIGETE 140
Cdd:PRK12573   81 ATGLASIFFGVPFLTHLFFYIPLPILGEVELTTAMLFDLGVYLVVVGVTMTIILTIGENE 140
 
Name Accession Description Interval E-value
PRK12573 PRK12573
Na(+)/H(+) antiporter subunit B;
1-140 1.72e-54

Na(+)/H(+) antiporter subunit B;


Pssm-ID: 183602 [Multi-domain]  Cd Length: 140  Bit Score: 167.37  E-value: 1.72e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164   1 MKTNDIIFQTATKVVVFIIILYSLHLFFSGHYTPGGGFIGGLMTAGALVLLLLAFDIKTVVNIIQVDYIKLIAVGLLFAV 80
Cdd:PRK12573    1 MKMNDLILRTVAKIVTFIILLFSVFLFLAGHNEPGGGFIGGLITASALVILLLAFDIKTVRRALPFDFKILAGIGLLFAI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164  81 LTGIGSFFFKVPFLTHTFSYVDLPFLGETALATAVLFDLGVYLVVIGVTMTIIQTIGETE 140
Cdd:PRK12573   81 ATGLASIFFGVPFLTHLFFYIPLPILGEVELTTAMLFDLGVYLVVVGVTMTIILTIGENE 140
2a6301s02 TIGR00943
monovalent cation:proton antiporter; This family of proteins constists of bacterial ...
 26-132 7.46e-32

monovalent cation:proton antiporter; This family of proteins constists of bacterial multicomponent K+:H+ and Na+:H+ antiporters. The best characterized systems are the PhaABCDEFG system of Rhizobium meliloti which functions in pH adaptation and as a K+ efflux system and the MnhABCDEFG system of Staphylococcus aureus which functions as a Na+:H+ antiporter.This family is specific for the phaB and mnhB proteins. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130018  Cd Length: 107  Bit Score: 109.07  E-value: 7.46e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164  26 LFFSGHYTPGGGFIGGLMTAGALVLLLLAFDIKTVVNIIQVDYIKLIAVGLLFAVLTGIGSFFFKVPFLTHTFSYVDLPF 105
Cdd:TIGR00943   1 LFLRGHNAPGGGFVAGLLTASSLILITIAFGIETVRKILPLDPKRLIGIGLLLAIATGVGSWFLGKPFLTSVTGYFPLPI 80

                          90       100
                  ....*....|....*....|....*..
gi 1325451164 106 LGETALATAVLFDLGVYLVVIGVTMTI 132
Cdd:TIGR00943  81 LGKFELATAVLFDLGVFCVVVGTTMLI 107
MnhB pfam04039
Domain related to MnhB subunit of Na+/H+ antiporter; Possible subunit of Na+/H+ antiporter,. ...
 7-131 3.05e-30

Domain related to MnhB subunit of Na+/H+ antiporter; Possible subunit of Na+/H+ antiporter,. Predicted integral membrane protein, usually four transmembrane regions in this domain. Often found in bacterial NADH dehydrogenase subunit.


Pssm-ID: 461141 [Multi-domain]  Cd Length: 125  Bit Score: 105.63  E-value: 3.05e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164   7 IFQTATKVVVFIIILYSLHLFFSGHYTPGGGFIGGLMTAGALVLLLLAFDIKTVVNIIQVDYIKLIAVGLLFAVLTGIGS 86
Cdd:pfam04039   1 ILRTVARLLFPLILLFSLYLLLRGHNSPGGGFQGGLVAAAALILLYLAFGREELRRLLPVDPLALEGLGLLLALLTGLLG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1325451164  87 FFFKVPFLTHTFSYVDLPFLGETALATAVLFDLGVYLVVIGVTMT 131
Cdd:pfam04039  81 LLFGGPFLTSAFLYVHLPLLGGVHLGTALLFDIGVYLKVVGGLLL 125
MnhB COG2111
Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism];
1-140 5.99e-17

Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism];


Pssm-ID: 441714 [Multi-domain]  Cd Length: 750  Bit Score: 75.90  E-value: 5.99e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164   1 MKTNDIIFQTATKVVVFIIILYSLHLFFSGHYTPGGGFIGGLMTAGALVLLLLAFDIKTVVNIIQVDYIKLIAVGLLFAV 80
Cdd:COG2111   610 AAAASLILSRLTRVLLPGILGFSVYLFFRGHNAPGGGFTGGLVEALALILLYLALGRLWVEERLPVDALILIGVGLLLAA 689

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164  81 LTGIGSFFFKVPFLTHTFsyvdLPFLGETALATAVLFDLGVYLVVIGVTMTIIQTIGETE 140
Cdd:COG2111   690 LTGLAALLFGGPFLTSAF----LPLAGGLNLVNAILFDFGVFDTVGGITVLILAALGRLR 745
 
Name Accession Description Interval E-value
PRK12573 PRK12573
Na(+)/H(+) antiporter subunit B;
1-140 1.72e-54

Na(+)/H(+) antiporter subunit B;


Pssm-ID: 183602 [Multi-domain]  Cd Length: 140  Bit Score: 167.37  E-value: 1.72e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164   1 MKTNDIIFQTATKVVVFIIILYSLHLFFSGHYTPGGGFIGGLMTAGALVLLLLAFDIKTVVNIIQVDYIKLIAVGLLFAV 80
Cdd:PRK12573    1 MKMNDLILRTVAKIVTFIILLFSVFLFLAGHNEPGGGFIGGLITASALVILLLAFDIKTVRRALPFDFKILAGIGLLFAI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164  81 LTGIGSFFFKVPFLTHTFSYVDLPFLGETALATAVLFDLGVYLVVIGVTMTIIQTIGETE 140
Cdd:PRK12573   81 ATGLASIFFGVPFLTHLFFYIPLPILGEVELTTAMLFDLGVYLVVVGVTMTIILTIGENE 140
PRK12574 PRK12574
monovalent cation/H+ antiporter subunit B;
1-138 3.17e-33

monovalent cation/H+ antiporter subunit B;


Pssm-ID: 183603 [Multi-domain]  Cd Length: 141  Bit Score: 113.60  E-value: 3.17e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164   1 MKTNDIIFQTATKVVVFIIILYSLHLFFSGHYTPGGGFIGGLMTAGALVLLLLAFDIKTVVNIIQVDYIKLIAVGLLFAV 80
Cdd:PRK12574    1 MKENDVVLKTVTKIVVFILLTFGFYLFLAGHNNPGGGFIGGLIFSSAFILMFLAFGVEEVLESLPIDFRKLMIIGLLLSS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1325451164  81 LTGIGSFFFKVPFLTHTFSYVDLPFLGETALATAVLFDLGVYLVVIGVTMTIIQTIGE 138
Cdd:PRK12574   81 ITAIIPMFFGKPFLRQAETFVILPLLGEIHLSSITLFELGILFVVVGVIVTIMLSLSG 138
PRK12648 PRK12648
putative monovalent cation/H+ antiporter subunit A; Reviewed
 18-137 1.79e-32

putative monovalent cation/H+ antiporter subunit A; Reviewed


Pssm-ID: 237157 [Multi-domain]  Cd Length: 948  Bit Score: 120.29  E-value: 1.79e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164  18 IIILYSLHLFFSGHYTPGGGFIGGLMTAGALVLLLLAFDIKTVVNIIQVDYIKLIAVGLLFAVLTGIGSFFFKVPFLTHT 97
Cdd:PRK12648  808 LALLVSVYLFLRGHNLPGGGFIAGLVLAIALILQYMASGTRWVEARLRILPHRWIGLGLLIAALTGLGSWLFGYPFLTSA 887

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1325451164  98 FSYVDLPFLGETALATAVLFDLGVYLVVIGVTMTIIQTIG 137
Cdd:PRK12648  888 FGYVHLPLIGEVELASALLFDLGVFLLVVGATLLILSALA 927
2a6301s02 TIGR00943
monovalent cation:proton antiporter; This family of proteins constists of bacterial ...
 26-132 7.46e-32

monovalent cation:proton antiporter; This family of proteins constists of bacterial multicomponent K+:H+ and Na+:H+ antiporters. The best characterized systems are the PhaABCDEFG system of Rhizobium meliloti which functions in pH adaptation and as a K+ efflux system and the MnhABCDEFG system of Staphylococcus aureus which functions as a Na+:H+ antiporter.This family is specific for the phaB and mnhB proteins. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130018  Cd Length: 107  Bit Score: 109.07  E-value: 7.46e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164  26 LFFSGHYTPGGGFIGGLMTAGALVLLLLAFDIKTVVNIIQVDYIKLIAVGLLFAVLTGIGSFFFKVPFLTHTFSYVDLPF 105
Cdd:TIGR00943   1 LFLRGHNAPGGGFVAGLLTASSLILITIAFGIETVRKILPLDPKRLIGIGLLLAIATGVGSWFLGKPFLTSVTGYFPLPI 80

                          90       100
                  ....*....|....*....|....*..
gi 1325451164 106 LGETALATAVLFDLGVYLVVIGVTMTI 132
Cdd:TIGR00943  81 LGKFELATAVLFDLGVFCVVVGTTMLI 107
MnhB pfam04039
Domain related to MnhB subunit of Na+/H+ antiporter; Possible subunit of Na+/H+ antiporter,. ...
 7-131 3.05e-30

Domain related to MnhB subunit of Na+/H+ antiporter; Possible subunit of Na+/H+ antiporter,. Predicted integral membrane protein, usually four transmembrane regions in this domain. Often found in bacterial NADH dehydrogenase subunit.


Pssm-ID: 461141 [Multi-domain]  Cd Length: 125  Bit Score: 105.63  E-value: 3.05e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164   7 IFQTATKVVVFIIILYSLHLFFSGHYTPGGGFIGGLMTAGALVLLLLAFDIKTVVNIIQVDYIKLIAVGLLFAVLTGIGS 86
Cdd:pfam04039   1 ILRTVARLLFPLILLFSLYLLLRGHNSPGGGFQGGLVAAAALILLYLAFGREELRRLLPVDPLALEGLGLLLALLTGLLG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1325451164  87 FFFKVPFLTHTFSYVDLPFLGETALATAVLFDLGVYLVVIGVTMT 131
Cdd:pfam04039  81 LLFGGPFLTSAFLYVHLPLLGGVHLGTALLFDIGVYLKVVGGLLL 125
PRK12509 PRK12509
Na+/H+ antiporter subunit B;
4-140 3.27e-26

Na+/H+ antiporter subunit B;


Pssm-ID: 237122 [Multi-domain]  Cd Length: 137  Bit Score: 95.81  E-value: 3.27e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164   4 NDIIFQTATKVVVFIIILYSLHLFFSGHYTPGGGFIGGLMTAGALVLLLLAFDIKTVVNIIQVDYIKLIAVGLLFAVLTG 83
Cdd:PRK12509    2 YSLILATASRFLLPLLLLFSVFLLLRGHNEPGGGFIGGLVAAAAFALYLIANGIAAARRLLRVDPLRLLAAGLLVAVLSG 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1325451164  84 IGSFFFKVPFLTHTFSYVDLPFLGEtaLATAVLFDLGVYLVVIGVTMTIIQTIGETE 140
Cdd:PRK12509   82 LPALFMGLPFLTALWWKLPLPLIGK--VGTPLLFDVGVYLLVLGSTLTIVFSLAEEE 136
PRK12644 PRK12644
putative monovalent cation/H+ antiporter subunit A; Reviewed
 6-137 1.81e-23

putative monovalent cation/H+ antiporter subunit A; Reviewed


Pssm-ID: 237154 [Multi-domain]  Cd Length: 965  Bit Score: 94.61  E-value: 1.81e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164   6 IIFQTATKVVVFIIILYSLHLFFSGHYTPGGGFIGGLMTAGALVLLLLA---FDIKTVVniiQVDYIKLIAVGLLFAVLT 82
Cdd:PRK12644  808 LVFEVVTRLLFPSMMVLSVYLLFAGHNAPGGGFAGGLVAGLALVLRYLAggrYELGEAL---PVDAGRLLGTGLFLSAGT 884

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1325451164  83 GIGSFFFKVPFLTHTFSYVDLPFLGETALATAVLFDLGVYLVVIGVTMTIIQTIG 137
Cdd:PRK12644  885 ALVSLLLGAPVLSSAIIEFDLPVLGDVKLVTALFFDLGVYLIVVGLVLDVLRSLG 939
MnhB COG2111
Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism];
1-140 5.99e-17

Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism];


Pssm-ID: 441714 [Multi-domain]  Cd Length: 750  Bit Score: 75.90  E-value: 5.99e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164   1 MKTNDIIFQTATKVVVFIIILYSLHLFFSGHYTPGGGFIGGLMTAGALVLLLLAFDIKTVVNIIQVDYIKLIAVGLLFAV 80
Cdd:COG2111   610 AAAASLILSRLTRVLLPGILGFSVYLFFRGHNAPGGGFTGGLVEALALILLYLALGRLWVEERLPVDALILIGVGLLLAA 689

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164  81 LTGIGSFFFKVPFLTHTFsyvdLPFLGETALATAVLFDLGVYLVVIGVTMTIIQTIGETE 140
Cdd:COG2111   690 LTGLAALLFGGPFLTSAF----LPLAGGLNLVNAILFDFGVFDTVGGITVLILAALGRLR 745
PRK12650 PRK12650
DUF4040 family protein;
4-137 9.68e-14

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 66.99  E-value: 9.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164   4 NDIIFQTATKVVVFIIILYSLHLFFSGHYTPGGGFIGGLMTAGALVLLLLAFDIKTVVNIIQVdYIKLIAVGLLFAVLTG 83
Cdd:PRK12650  784 NSVPLRMLLRVLIPILILLSFALFWRGHNEPGGGFIAALVAGAGLMLLYLSAPRDKAIFVRNP-PLTLIGAGILVAVVTG 862

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1325451164  84 IgsfffkVPFLTHTFSY-VDLPFLGEtALATAVLFDLGVYLVVIGVTMTIIQTIG 137
Cdd:PRK12650  863 L------LGYLHGSFLYpIHGHVLGQ-HWTTSLIFDLGVYLAVLGMVSMAINLLG 910
PRK12508 PRK12508
Na(+)/H(+) antiporter subunit B;
5-132 9.11e-07

Na(+)/H(+) antiporter subunit B;


Pssm-ID: 183563  Cd Length: 139  Bit Score: 45.37  E-value: 9.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164   5 DIIFQTATKVVVFIIILYSLHLFFSGHYTPGGGFIGGLMTAGALVLLLLAFDIKTVVNIIQVDYIKLI-AVGLLFAVLTG 83
Cdd:PRK12508    4 NPILRTITKLMIPVIILFGLYVQFHGDYGPGGGFQAGVIVASAIILYSMLFGLSATLKAVPPSFVRLMaALGVLIYGGTG 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1325451164  84 IGSFFFKVPFLTHTFSYVDlPFLGEtalatavlfDLGVYLVVIGVTMTI 132
Cdd:PRK12508   84 IASMLLGGNFLSYDVLIFD-SVTGQ---------HLGIFLVELGVGLTV 122
PRK12507 PRK12507
putative monovalent cation/H+ antiporter subunit B; Reviewed
 2-132 4.80e-05

putative monovalent cation/H+ antiporter subunit B; Reviewed


Pssm-ID: 237121 [Multi-domain]  Cd Length: 332  Bit Score: 41.57  E-value: 4.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164   2 KTNDIIFQTATKVVVFIIILYSLHLFFSGHYTPGGGFIGGLMTAGALVLLLLAFDIKTVVNIIQVDYIKLIAV-GLLFAV 80
Cdd:PRK12507  194 SQHYPILKYISKFLIPYIILFSLYVQFHGEFSPGGGFQAGVIFASAIILYAMLYGLRKASRYFPPNVLILIAAlGVAIYA 273

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1325451164  81 LTGIGSFFFKVPFLTHT--FSYVDLPFLGEtalatavlfDLGVYLVVIGVTMTI 132
Cdd:PRK12507  274 IVGVISLFNGGNFLDYYslTNFINDPLLGQ---------HIGILIVEIGVGLTV 318
PRK12567 PRK12567
putative monovalent cation/H+ antiporter subunit B; Reviewed
 4-41 1.80e-03

putative monovalent cation/H+ antiporter subunit B; Reviewed


Pssm-ID: 237140 [Multi-domain]  Cd Length: 218  Bit Score: 36.80  E-value: 1.80e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1325451164   4 NDIIFQTATKVVVFIIILYSLHLFFSGHYTPGGGFIGG 41
Cdd:PRK12567   88 SDVPLRVLARLLAPFILLFGIYLAIHGHLTPGGGFAAG 125
PRK08387 PRK08387
putative monovalent cation/H+ antiporter subunit B; Reviewed
 6-95 6.10e-03

putative monovalent cation/H+ antiporter subunit B; Reviewed


Pssm-ID: 169420  Cd Length: 131  Bit Score: 34.78  E-value: 6.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1325451164   6 IIFQTATKVVVFIIILYSLHLFFSGHYTPGGGFIGGLMTAGALVLLLLAFDIKTVVNIIQVDYIKLI-AVGLLFAVLTGI 84
Cdd:PRK08387    3 LVVRTTTKLVAPFLVTYAAYLMLYGHLSPGGGFQAGVILAVAVILLITSHGYKKVRKRFRKRTVSLLeSSSGLFIVGLGI 82

                          90
                  ....*....|.
gi 1325451164  85 GSFFFKVPFLT 95
Cdd:PRK08387   83 AGLLFGLFFLN 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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