NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1317522659|gb|PKZ16348|]
View 

threonine transporter RhtB [Alloscardovia omnicolens]

Protein Classification

DMT family transporter( domain architecture ID 11472027)

DMT (drug/metabolite transporter) family transporter similar to threonine/homoserine exporter RhtA, which is involved in the efflux of threonine and homoserine, and can also export other amino acids such as proline, serine, histidine, and cysteine

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RhtA COG5006
Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];
2-271 3.18e-46

Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];


:

Pssm-ID: 444030 [Multi-domain]  Cd Length: 290  Bit Score: 157.67  E-value: 3.18e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317522659   2 SKIAFTQIEPLLVSWWRMAFTVLIMVLWRRPfsirKRANLPKdaKTWIILGALGVAVAGMNGVFYIAINTLNSGVAVAIE 81
Cdd:COG5006    28 AKLLFPGVGPLGVTALRLAFAALILLLIFRP----WRRRLTR--RDWLALLLYGVALAGMNLLFYLAIARIPLGIAVALE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317522659  82 FIGPLAVAVFTGRTWREYMGAFLAFAGLLTLAGAALfSVGPSSIPGLVAIIASGVLWGIYIVLGRHVAHGSSGLDNLTIS 161
Cdd:COG5006   102 FLGPLAVALLGSRRRRDLLWVALALAGVVLLLPVGL-SGGSLDPVGVLFALGAAACWALYILLGRRVGARLPGLTGLALG 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317522659 162 LLIGWIiqscfigfpavkaVIVPAQFATWARADGGWfKLLVLLFIMTLGASIVSYIFDQVLMRRVSVNRFSVMQSVLPAV 241
Cdd:COG5006   181 MLVAAL-------------VLLPFGLPTAGPALLDP-PVLLLGLGVAVLSSVLPYSLEMVALRRLPARTFGILMSLEPAV 246

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1317522659 242 NLIISM-FFGDRPGVMDFVGVGIIVFAVIIS 271
Cdd:COG5006   247 AALAGWlVLGEVLTPLQWLGIALVVAASAGA 277
 
Name Accession Description Interval E-value
RhtA COG5006
Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];
2-271 3.18e-46

Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];


Pssm-ID: 444030 [Multi-domain]  Cd Length: 290  Bit Score: 157.67  E-value: 3.18e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317522659   2 SKIAFTQIEPLLVSWWRMAFTVLIMVLWRRPfsirKRANLPKdaKTWIILGALGVAVAGMNGVFYIAINTLNSGVAVAIE 81
Cdd:COG5006    28 AKLLFPGVGPLGVTALRLAFAALILLLIFRP----WRRRLTR--RDWLALLLYGVALAGMNLLFYLAIARIPLGIAVALE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317522659  82 FIGPLAVAVFTGRTWREYMGAFLAFAGLLTLAGAALfSVGPSSIPGLVAIIASGVLWGIYIVLGRHVAHGSSGLDNLTIS 161
Cdd:COG5006   102 FLGPLAVALLGSRRRRDLLWVALALAGVVLLLPVGL-SGGSLDPVGVLFALGAAACWALYILLGRRVGARLPGLTGLALG 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317522659 162 LLIGWIiqscfigfpavkaVIVPAQFATWARADGGWfKLLVLLFIMTLGASIVSYIFDQVLMRRVSVNRFSVMQSVLPAV 241
Cdd:COG5006   181 MLVAAL-------------VLLPFGLPTAGPALLDP-PVLLLGLGVAVLSSVLPYSLEMVALRRLPARTFGILMSLEPAV 246

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1317522659 242 NLIISM-FFGDRPGVMDFVGVGIIVFAVIIS 271
Cdd:COG5006   247 AALAGWlVLGEVLTPLQWLGIALVVAASAGA 277
PRK10532 PRK10532
threonine and homoserine efflux system; Provisional
 18-168 1.37e-12

threonine and homoserine efflux system; Provisional


Pssm-ID: 182525 [Multi-domain]  Cd Length: 293  Bit Score: 66.63  E-value: 1.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317522659  18 RMAFTVLIMVLWRRPFSIR--KRANLPkdaktwiiLGALGVAVAGMNGVFYIAINTLNSGVAVAIEFIGPLAVAVFTGRT 95
Cdd:PRK10532   47 RLALGTLILIAIFKPWRLRfaKEQRLP--------LLFYGVSLGGMNYLFYLSIQTVPLGIAVALEFTGPLAVALFSSRR 118

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1317522659  96 WREYMGAFLAFAGLLTL--AGAALFSVGPSsipGLVAIIASGVLWGIYIVLGRHvAHGSSGLDNLTISLLIGWII 168
Cdd:PRK10532  119 PVDFVWVVLAVLGLWFLlpLGQDVSHVDLT---GAALALGAGACWAIYILSGQR-AGAEHGPATVAIGSLIAALI 189
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 1-120 1.39e-03

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 38.33  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317522659   1 MSKIAFTQIEPLLVSWWRMAFTVLIMVlwrrPFSIRKRANLPKDAKTWIILGALGV-AVAGMNGVFYIAINTLNSGVAVA 79
Cdd:pfam00892  20 FSKILLRRISPLTLTFWRFLIAGILLL----PFALFTGGKLVIPLKSWLALLYLGVlGTFLGFLLYFYGLKYVSASNASV 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1317522659  80 IEFIGPLAVAVFTGRTWREYMGAFLAFAGLLTLAGAALFSV 120
Cdd:pfam00892  96 ITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
 
Name Accession Description Interval E-value
RhtA COG5006
Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];
2-271 3.18e-46

Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];


Pssm-ID: 444030 [Multi-domain]  Cd Length: 290  Bit Score: 157.67  E-value: 3.18e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317522659   2 SKIAFTQIEPLLVSWWRMAFTVLIMVLWRRPfsirKRANLPKdaKTWIILGALGVAVAGMNGVFYIAINTLNSGVAVAIE 81
Cdd:COG5006    28 AKLLFPGVGPLGVTALRLAFAALILLLIFRP----WRRRLTR--RDWLALLLYGVALAGMNLLFYLAIARIPLGIAVALE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317522659  82 FIGPLAVAVFTGRTWREYMGAFLAFAGLLTLAGAALfSVGPSSIPGLVAIIASGVLWGIYIVLGRHVAHGSSGLDNLTIS 161
Cdd:COG5006   102 FLGPLAVALLGSRRRRDLLWVALALAGVVLLLPVGL-SGGSLDPVGVLFALGAAACWALYILLGRRVGARLPGLTGLALG 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317522659 162 LLIGWIiqscfigfpavkaVIVPAQFATWARADGGWfKLLVLLFIMTLGASIVSYIFDQVLMRRVSVNRFSVMQSVLPAV 241
Cdd:COG5006   181 MLVAAL-------------VLLPFGLPTAGPALLDP-PVLLLGLGVAVLSSVLPYSLEMVALRRLPARTFGILMSLEPAV 246

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1317522659 242 NLIISM-FFGDRPGVMDFVGVGIIVFAVIIS 271
Cdd:COG5006   247 AALAGWlVLGEVLTPLQWLGIALVVAASAGA 277
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 1-271 4.60e-22

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 93.37  E-value: 4.60e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317522659   1 MSKIAFTQIEPLLVSWWRMAFTVLIMVLWRRPFSIRKRANLPKDAKTWIILGALGVAVAgmNGVFYIAINTLNSGVAVAI 80
Cdd:COG0697    21 AIKLALAGLPPLQLAFLRFLLAALLLLPLLLLRGRRLPPLSRRDWLLLLLRGLLGLALA--FLLFFLALQYTPAALAALL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317522659  81 EFIGPLAVAVFTGRTWREYMGAFLAFAGLLTLAGAAL-----FSVGPSSIPGLVAIIASGVLWGIYIVLGRHVAHGSSGL 155
Cdd:COG0697    99 LALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLivgpgGGGGGGSLLGDLLALLAALSWALYTVLTRRLSRRLDPL 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317522659 156 DNLTISLLIGWIIQSCFIGFPAVKAVIVPAQFAtwaradggwfkllvLLFIMTLGASIVSYIFDQVLMRRVSVNRFSVMQ 235
Cdd:COG0697   179 TLTFWQMLVGALLLLPLALLTGLPLPLSAAAWL--------------ALLYLGLFGTALAYLLWFRALRRLGASRAAPLT 244

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1317522659 236 SVLPAVNLIISM-FFGDRPGVMDFVGVGIIVFAVIIS 271
Cdd:COG0697   245 YLEPVFAVLLGWlLLGEPLTPLQLLGAALILAGVLLA 281
PRK10532 PRK10532
threonine and homoserine efflux system; Provisional
 18-168 1.37e-12

threonine and homoserine efflux system; Provisional


Pssm-ID: 182525 [Multi-domain]  Cd Length: 293  Bit Score: 66.63  E-value: 1.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317522659  18 RMAFTVLIMVLWRRPFSIR--KRANLPkdaktwiiLGALGVAVAGMNGVFYIAINTLNSGVAVAIEFIGPLAVAVFTGRT 95
Cdd:PRK10532   47 RLALGTLILIAIFKPWRLRfaKEQRLP--------LLFYGVSLGGMNYLFYLSIQTVPLGIAVALEFTGPLAVALFSSRR 118

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1317522659  96 WREYMGAFLAFAGLLTL--AGAALFSVGPSsipGLVAIIASGVLWGIYIVLGRHvAHGSSGLDNLTISLLIGWII 168
Cdd:PRK10532  119 PVDFVWVVLAVLGLWFLlpLGQDVSHVDLT---GAALALGAGACWAIYILSGQR-AGAEHGPATVAIGSLIAALI 189
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 1-120 1.39e-03

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 38.33  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317522659   1 MSKIAFTQIEPLLVSWWRMAFTVLIMVlwrrPFSIRKRANLPKDAKTWIILGALGV-AVAGMNGVFYIAINTLNSGVAVA 79
Cdd:pfam00892  20 FSKILLRRISPLTLTFWRFLIAGILLL----PFALFTGGKLVIPLKSWLALLYLGVlGTFLGFLLYFYGLKYVSASNASV 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1317522659  80 IEFIGPLAVAVFTGRTWREYMGAFLAFAGLLTLAGAALFSV 120
Cdd:pfam00892  96 ITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 125-273 1.51e-03

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 37.94  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317522659 125 IPGLVAIIASGVLWGIYIVLGRHVAHGSSGLDNLTISLLIGWIIQSCFIGFPAVKAVIVPAQFAtwaradggwfkllvLL 204
Cdd:pfam00892   1 LKGILLALLAALIWAIYFVFSKILLRRISPLTLTFWRFLIAGILLLPFALFTGGKLVIPLKSWL--------------AL 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1317522659 205 FIMTLGASIVSYIFDQVLMRRVSVNRFSVMQSVLPAVNLIISMFF-GDRPGVMDFVGVGIIVFAVIISFS 273
Cdd:pfam00892  67 LYLGVLGTFLGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLlGEKLTLKQLLGIVLILLGVLLILL 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH