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Conserved domains on  [gi|1315820081|gb|PKV76429|]
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hypothetical protein BD749_1382 [Pontibacter ramchanderi]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MG2 super family cl47206
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
 66-149 6.32e-04

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


The actual alignment was detected with superfamily member pfam01835:

Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 39.61  E-value: 6.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315820081  66 KLYLHIDRPVYACGDELWFKVYNVDGSLhRPLDMSKVTyVELLDADQKPALQAK-VAMKDGVGNGYFQLPTTLQTGNYTV 144
Cdd:pfam01835   1 RAFVYTDRGIYRPGETVHFKGLLRDQDL-RPLAGLPVT-LTVTDPDGNEVRRLPlTTDEFGGFSGSFPLPETAPTGTYTV 78


                  ....*
gi 1315820081 145 RAYTS 149
Cdd:pfam01835  79 VLRDG 83
 
Name Accession Description Interval E-value
MG2 pfam01835
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
 66-149 6.32e-04

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 39.61  E-value: 6.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315820081  66 KLYLHIDRPVYACGDELWFKVYNVDGSLhRPLDMSKVTyVELLDADQKPALQAK-VAMKDGVGNGYFQLPTTLQTGNYTV 144
Cdd:pfam01835   1 RAFVYTDRGIYRPGETVHFKGLLRDQDL-RPLAGLPVT-LTVTDPDGNEVRRLPlTTDEFGGFSGSFPLPETAPTGTYTV 78


                  ....*
gi 1315820081 145 RAYTS 149
Cdd:pfam01835  79 VLRDG 83
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
 59-148 8.41e-04

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 43.15  E-value: 8.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315820081   59 RQAALQEKLYLHIDRPVYACGDELWFK--VYNVDGslhRPLDMSKVTyVELLDADQKPALQAKVamKDGVGNGY---FQL 133
Cdd:COG2373    363 RAPPGGLDAFLFTDRGIYRPGETVHLKalLRDADG---KAPAGLPLT-LELTDPDGKEVRRQTL--TLNEFGGYsfsFPL 436

                           90
                   ....*....|....*
gi 1315820081  134 PTTLQTGNYTVRAYT 148
Cdd:COG2373    437 PEDAPTGTWRLELYV 451
 
Name Accession Description Interval E-value
MG2 pfam01835
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
 66-149 6.32e-04

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 39.61  E-value: 6.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315820081  66 KLYLHIDRPVYACGDELWFKVYNVDGSLhRPLDMSKVTyVELLDADQKPALQAK-VAMKDGVGNGYFQLPTTLQTGNYTV 144
Cdd:pfam01835   1 RAFVYTDRGIYRPGETVHFKGLLRDQDL-RPLAGLPVT-LTVTDPDGNEVRRLPlTTDEFGGFSGSFPLPETAPTGTYTV 78


                  ....*
gi 1315820081 145 RAYTS 149
Cdd:pfam01835  79 VLRDG 83
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
 59-148 8.41e-04

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 43.15  E-value: 8.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1315820081   59 RQAALQEKLYLHIDRPVYACGDELWFK--VYNVDGslhRPLDMSKVTyVELLDADQKPALQAKVamKDGVGNGY---FQL 133
Cdd:COG2373    363 RAPPGGLDAFLFTDRGIYRPGETVHLKalLRDADG---KAPAGLPLT-LELTDPDGKEVRRQTL--TLNEFGGYsfsFPL 436

                           90
                   ....*....|....*
gi 1315820081  134 PTTLQTGNYTVRAYT 148
Cdd:COG2373    437 PEDAPTGTWRLELYV 451
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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