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Conserved domains on  [gi|1308446927|gb|PKK85092|]
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MAG: hypothetical protein CVT49_00695 [candidate division Zixibacteria bacterium HGW-Zixibacteria-1]

Protein Classification

cytochrome c3 family protein( domain architecture ID 10629010)

cytochrome c3 (class III cytochrome c) family protein similar to Geobacter sulfurreducens triheme cytochromes c7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cytochrome_C7 pfam14522
Cytochrome c7 and related cytochrome c; This family includes cytochromes c7 and c7-type. In ...
 106-159 4.96e-05

Cytochrome c7 and related cytochrome c; This family includes cytochromes c7 and c7-type. In cytochromes c7 all three haems are bis-His co-ordinated, while in c7-type the last haem is His-Met co-ordinated. Desulfuromonas acetoxidans and Geobacter metallireducens cytochrome c7 participate in the anaerobic iron respiration, but Geobacter metallireducens cytochrome c7 hasn't a Fe(III) reductase activity. This entry also includes cytochrome c nitrite reductase subunit NrfH from Desulfovibrio vulgaris which forms a complex with cytochrome c nitrite reductase NrfA.


:

Pssm-ID: 434012 [Multi-domain]  Cd Length: 62  Bit Score: 40.74  E-value: 4.96e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1308446927 106 FNHKKHFEQKIKCTHCHDGIAESRESSTTYMPTMPLCMTCHDGIKAD-----NSCALCH 159
Cdd:pfam14522   3 FSHDVHLAGGYNCADCHNKLFASKRVTMAEMEKGKSCGACHDGKTAFsvadkGNCGRCH 61
decahem_SO1788 super family cl28266
decaheme c-type cytochrome, OmcA/MtrC family; The protein SO_1778 (MtrC) of Shewanella ...
 151-289 1.86e-04

decaheme c-type cytochrome, OmcA/MtrC family; The protein SO_1778 (MtrC) of Shewanella oneidensis MR-1, and its paralog SO_1779 (OmcA), with which it intteracts, are large decaheme proteins, about 900 amino acids in length, involved in the use of manganese [Mn(III/IV)] and iron [Fe(III)] as terminal electron acceptors. This model represents these and similar decaheme proteins, found also in Rhodoferax ferrireducens DSM 15236, Aeromonas hydrophila ATCC7966, and a few other bacterial species. [Energy metabolism, Electron transport]


The actual alignment was detected with superfamily member TIGR03507:

Pssm-ID: 274617 [Multi-domain]  Cd Length: 659  Bit Score: 43.29  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308446927 151 ADNSCALCHGQritlLDIHpqdwrhqHGDRAtsDPEFCGGCHRSERFCAECHREDNLEGNIHDL-NYEYTHGLDAG---- 225
Cdd:TIGR03507 156 SIAACNSCHGE----LALH-------GGRRI--DVELCVTCHNPSTADPGSGNSLDFAVMIHKIhMGKKLPSVDSGdpyi 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308446927 226 ---------------SKEKDCARCH--------DRKLF--------CNACHERQNRIPLEHstlnwlseHGLAARNDIEN 274
Cdd:TIGR03507 223 gygnakidfsdvgfpQDPRNCTTCHsgantktaDADNWktvpsmaaCGSCHDNVNFATGAN--------HVNQTQADDTQ 294

                         170
                  ....*....|....*
gi 1308446927 275 CASCHDSSDPTCARG 289
Cdd:TIGR03507 295 CAACHNAGSTASAHT 309
 
Name Accession Description Interval E-value
Cytochrome_C7 pfam14522
Cytochrome c7 and related cytochrome c; This family includes cytochromes c7 and c7-type. In ...
 106-159 4.96e-05

Cytochrome c7 and related cytochrome c; This family includes cytochromes c7 and c7-type. In cytochromes c7 all three haems are bis-His co-ordinated, while in c7-type the last haem is His-Met co-ordinated. Desulfuromonas acetoxidans and Geobacter metallireducens cytochrome c7 participate in the anaerobic iron respiration, but Geobacter metallireducens cytochrome c7 hasn't a Fe(III) reductase activity. This entry also includes cytochrome c nitrite reductase subunit NrfH from Desulfovibrio vulgaris which forms a complex with cytochrome c nitrite reductase NrfA.


Pssm-ID: 434012 [Multi-domain]  Cd Length: 62  Bit Score: 40.74  E-value: 4.96e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1308446927 106 FNHKKHFEQKIKCTHCHDGIAESRESSTTYMPTMPLCMTCHDGIKAD-----NSCALCH 159
Cdd:pfam14522   3 FSHDVHLAGGYNCADCHNKLFASKRVTMAEMEKGKSCGACHDGKTAFsvadkGNCGRCH 61
decahem_SO1788 TIGR03507
decaheme c-type cytochrome, OmcA/MtrC family; The protein SO_1778 (MtrC) of Shewanella ...
 70-160 5.37e-05

decaheme c-type cytochrome, OmcA/MtrC family; The protein SO_1778 (MtrC) of Shewanella oneidensis MR-1, and its paralog SO_1779 (OmcA), with which it intteracts, are large decaheme proteins, about 900 amino acids in length, involved in the use of manganese [Mn(III/IV)] and iron [Fe(III)] as terminal electron acceptors. This model represents these and similar decaheme proteins, found also in Rhodoferax ferrireducens DSM 15236, Aeromonas hydrophila ATCC7966, and a few other bacterial species. [Energy metabolism, Electron transport]


Pssm-ID: 274617 [Multi-domain]  Cd Length: 659  Bit Score: 44.83  E-value: 5.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308446927  70 EVCGDCHD--------IEEVDGCGTCHR-SIDDPQALPNPDRPIeFNHKKH----------------------------F 112
Cdd:TIGR03507 158 AACNSCHGelalhggrRIDVELCVTCHNpSTADPGSGNSLDFAV-MIHKIHmgkklpsvdsgdpyigygnakidfsdvgF 236

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1308446927 113 EQKIK-CTHCHDGIAESRESSTTY--MPTMPLCMTCHD-------------GIKADNSCALCHG 160
Cdd:TIGR03507 237 PQDPRnCTTCHSGANTKTADADNWktVPSMAACGSCHDnvnfatganhvnqTQADDTQCAACHN 300
decahem_SO1788 TIGR03507
decaheme c-type cytochrome, OmcA/MtrC family; The protein SO_1778 (MtrC) of Shewanella ...
 151-289 1.86e-04

decaheme c-type cytochrome, OmcA/MtrC family; The protein SO_1778 (MtrC) of Shewanella oneidensis MR-1, and its paralog SO_1779 (OmcA), with which it intteracts, are large decaheme proteins, about 900 amino acids in length, involved in the use of manganese [Mn(III/IV)] and iron [Fe(III)] as terminal electron acceptors. This model represents these and similar decaheme proteins, found also in Rhodoferax ferrireducens DSM 15236, Aeromonas hydrophila ATCC7966, and a few other bacterial species. [Energy metabolism, Electron transport]


Pssm-ID: 274617 [Multi-domain]  Cd Length: 659  Bit Score: 43.29  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308446927 151 ADNSCALCHGQritlLDIHpqdwrhqHGDRAtsDPEFCGGCHRSERFCAECHREDNLEGNIHDL-NYEYTHGLDAG---- 225
Cdd:TIGR03507 156 SIAACNSCHGE----LALH-------GGRRI--DVELCVTCHNPSTADPGSGNSLDFAVMIHKIhMGKKLPSVDSGdpyi 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308446927 226 ---------------SKEKDCARCH--------DRKLF--------CNACHERQNRIPLEHstlnwlseHGLAARNDIEN 274
Cdd:TIGR03507 223 gygnakidfsdvgfpQDPRNCTTCHsgantktaDADNWktvpsmaaCGSCHDNVNFATGAN--------HVNQTQADDTQ 294

                         170
                  ....*....|....*
gi 1308446927 275 CASCHDSSDPTCARG 289
Cdd:TIGR03507 295 CAACHNAGSTASAHT 309
Cytochrom_C3 cd08168
Heme-binding domain of the class III cytochrome C family and related proteins; This alignment ...
 103-193 2.42e-03

Heme-binding domain of the class III cytochrome C family and related proteins; This alignment models heme binding core motifs as encountered in the cytochrome C3 family and related proteins. Cytochrome C3 is a tetraheme protein found in sulfate-reducing bacteria which use either thiosulfate or sulfate as the ultimate electron acceptors. C3 is an integral part of a complex electron transfer chain. The model also contains triheme cytochromes C7 which function in electron transfer during Fe(III) respiration by Geobacter sulfurreducens (PpcA, PpcB, PpcC, PpcD, and PpcE) and four repeated core motifs as found in the 16-heme cytochrome C HmcA of Desulfovibrio vulgaris Hildenborough which plays a role in electron transfer through the membrane following periplasmic oxidation of hydrogen (resulting in sulfate reduction in the cytoplasm).


Pssm-ID: 173979 [Multi-domain]  Cd Length: 85  Bit Score: 36.45  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308446927 103 PIEFNHKKHFEQ-KIKCTHCHDGIAESressttyMPTMPLCMTCHDGIKAD------------NSCALCHGQritlldih 169
Cdd:cd08168     3 PVPFPHKKHAEAlGIDCRTCHHKYEGG-------KGEPQKCAECHSHDGTDdpdfvslkdafhNSCIGCHKE-------- 67

                          90       100
                  ....*....|....*....|....
gi 1308446927 170 pqdwrhQHGDRATSDPEFCGGCHR 193
Cdd:cd08168    68 ------MAKAGKKTGPVGCAGCHK 85
 
Name Accession Description Interval E-value
Cytochrome_C7 pfam14522
Cytochrome c7 and related cytochrome c; This family includes cytochromes c7 and c7-type. In ...
 106-159 4.96e-05

Cytochrome c7 and related cytochrome c; This family includes cytochromes c7 and c7-type. In cytochromes c7 all three haems are bis-His co-ordinated, while in c7-type the last haem is His-Met co-ordinated. Desulfuromonas acetoxidans and Geobacter metallireducens cytochrome c7 participate in the anaerobic iron respiration, but Geobacter metallireducens cytochrome c7 hasn't a Fe(III) reductase activity. This entry also includes cytochrome c nitrite reductase subunit NrfH from Desulfovibrio vulgaris which forms a complex with cytochrome c nitrite reductase NrfA.


Pssm-ID: 434012 [Multi-domain]  Cd Length: 62  Bit Score: 40.74  E-value: 4.96e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1308446927 106 FNHKKHFEQKIKCTHCHDGIAESRESSTTYMPTMPLCMTCHDGIKAD-----NSCALCH 159
Cdd:pfam14522   3 FSHDVHLAGGYNCADCHNKLFASKRVTMAEMEKGKSCGACHDGKTAFsvadkGNCGRCH 61
decahem_SO1788 TIGR03507
decaheme c-type cytochrome, OmcA/MtrC family; The protein SO_1778 (MtrC) of Shewanella ...
 70-160 5.37e-05

decaheme c-type cytochrome, OmcA/MtrC family; The protein SO_1778 (MtrC) of Shewanella oneidensis MR-1, and its paralog SO_1779 (OmcA), with which it intteracts, are large decaheme proteins, about 900 amino acids in length, involved in the use of manganese [Mn(III/IV)] and iron [Fe(III)] as terminal electron acceptors. This model represents these and similar decaheme proteins, found also in Rhodoferax ferrireducens DSM 15236, Aeromonas hydrophila ATCC7966, and a few other bacterial species. [Energy metabolism, Electron transport]


Pssm-ID: 274617 [Multi-domain]  Cd Length: 659  Bit Score: 44.83  E-value: 5.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308446927  70 EVCGDCHD--------IEEVDGCGTCHR-SIDDPQALPNPDRPIeFNHKKH----------------------------F 112
Cdd:TIGR03507 158 AACNSCHGelalhggrRIDVELCVTCHNpSTADPGSGNSLDFAV-MIHKIHmgkklpsvdsgdpyigygnakidfsdvgF 236

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1308446927 113 EQKIK-CTHCHDGIAESRESSTTY--MPTMPLCMTCHD-------------GIKADNSCALCHG 160
Cdd:TIGR03507 237 PQDPRnCTTCHSGANTKTADADNWktVPSMAACGSCHDnvnfatganhvnqTQADDTQCAACHN 300
decahem_SO1788 TIGR03507
decaheme c-type cytochrome, OmcA/MtrC family; The protein SO_1778 (MtrC) of Shewanella ...
 151-289 1.86e-04

decaheme c-type cytochrome, OmcA/MtrC family; The protein SO_1778 (MtrC) of Shewanella oneidensis MR-1, and its paralog SO_1779 (OmcA), with which it intteracts, are large decaheme proteins, about 900 amino acids in length, involved in the use of manganese [Mn(III/IV)] and iron [Fe(III)] as terminal electron acceptors. This model represents these and similar decaheme proteins, found also in Rhodoferax ferrireducens DSM 15236, Aeromonas hydrophila ATCC7966, and a few other bacterial species. [Energy metabolism, Electron transport]


Pssm-ID: 274617 [Multi-domain]  Cd Length: 659  Bit Score: 43.29  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308446927 151 ADNSCALCHGQritlLDIHpqdwrhqHGDRAtsDPEFCGGCHRSERFCAECHREDNLEGNIHDL-NYEYTHGLDAG---- 225
Cdd:TIGR03507 156 SIAACNSCHGE----LALH-------GGRRI--DVELCVTCHNPSTADPGSGNSLDFAVMIHKIhMGKKLPSVDSGdpyi 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308446927 226 ---------------SKEKDCARCH--------DRKLF--------CNACHERQNRIPLEHstlnwlseHGLAARNDIEN 274
Cdd:TIGR03507 223 gygnakidfsdvgfpQDPRNCTTCHsgantktaDADNWktvpsmaaCGSCHDNVNFATGAN--------HVNQTQADDTQ 294

                         170
                  ....*....|....*
gi 1308446927 275 CASCHDSSDPTCARG 289
Cdd:TIGR03507 295 CAACHNAGSTASAHT 309
Cytochrom_C3 cd08168
Heme-binding domain of the class III cytochrome C family and related proteins; This alignment ...
 103-193 2.42e-03

Heme-binding domain of the class III cytochrome C family and related proteins; This alignment models heme binding core motifs as encountered in the cytochrome C3 family and related proteins. Cytochrome C3 is a tetraheme protein found in sulfate-reducing bacteria which use either thiosulfate or sulfate as the ultimate electron acceptors. C3 is an integral part of a complex electron transfer chain. The model also contains triheme cytochromes C7 which function in electron transfer during Fe(III) respiration by Geobacter sulfurreducens (PpcA, PpcB, PpcC, PpcD, and PpcE) and four repeated core motifs as found in the 16-heme cytochrome C HmcA of Desulfovibrio vulgaris Hildenborough which plays a role in electron transfer through the membrane following periplasmic oxidation of hydrogen (resulting in sulfate reduction in the cytoplasm).


Pssm-ID: 173979 [Multi-domain]  Cd Length: 85  Bit Score: 36.45  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1308446927 103 PIEFNHKKHFEQ-KIKCTHCHDGIAESressttyMPTMPLCMTCHDGIKAD------------NSCALCHGQritlldih 169
Cdd:cd08168     3 PVPFPHKKHAEAlGIDCRTCHHKYEGG-------KGEPQKCAECHSHDGTDdpdfvslkdafhNSCIGCHKE-------- 67

                          90       100
                  ....*....|....*....|....
gi 1308446927 170 pqdwrhQHGDRATSDPEFCGGCHR 193
Cdd:cd08168    68 ------MAKAGKKTGPVGCAGCHK 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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