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Conserved domains on  [gi|1238321544|gb|PAN44177|]
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hypothetical protein PAHAL_9G022500 [Panicum hallii]

Protein Classification

huntingtin-interacting protein K( domain architecture ID 16075013)

huntingtin-interacting protein K (HYPK) is an intrinsically unstructured Huntingtin (HTT)-interacting protein with chaperone-like activity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HYPK_UBA pfam19026
HYPK UBA domain; This entry represents the UBA domain found at the C-terminus of the HYPK ...
 81-121 2.57e-11

HYPK UBA domain; This entry represents the UBA domain found at the C-terminus of the HYPK protein and its homologs. This domain in HYPK mediates a protein interaction with the Naa15 C-terminus.


:

Pssm-ID: 436907  Cd Length: 41  Bit Score: 54.10  E-value: 2.57e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1238321544  81 VKINPTDVEIIANELELDKKIAERTLREHKGDAVAAVRFLL 121
Cdd:pfam19026   1 VKVKKEDVELIMTELEVSKAKAERALREHGGDVVAALRALL 41
 
Name Accession Description Interval E-value
HYPK_UBA pfam19026
HYPK UBA domain; This entry represents the UBA domain found at the C-terminus of the HYPK ...
 81-121 2.57e-11

HYPK UBA domain; This entry represents the UBA domain found at the C-terminus of the HYPK protein and its homologs. This domain in HYPK mediates a protein interaction with the Naa15 C-terminus.


Pssm-ID: 436907  Cd Length: 41  Bit Score: 54.10  E-value: 2.57e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1238321544  81 VKINPTDVEIIANELELDKKIAERTLREHKGDAVAAVRFLL 121
Cdd:pfam19026   1 VKVKKEDVELIMTELEVSKAKAERALREHGGDVVAALRALL 41
UBA_HYPK cd14361
UBA-like domain found in Huntingtin-interacting protein K (HYPK) and similar proteins; HYPK, ...
 81-121 3.33e-11

UBA-like domain found in Huntingtin-interacting protein K (HYPK) and similar proteins; HYPK, also called Huntingtin yeast partner K or Huntingtin yeast two-hybrid protein K, is an intrinsically unstructured Huntingtin (HTT)-interacting protein with chaperone-like activity. It is involved in regulating cell growth, cell cycle, unfolded protein response, and cell death. All members in this subfamily contain an N-terminal ubiquitin-associated (UBA) that shows high sequence similarity with that of eukaryotic nascent polypeptide-associated complex proteins (NAC) which is one of the cytosolic chaperones that contact the nascent polypeptide chains as they emerge from the ribosome and assist in post-translational processes.


Pssm-ID: 270544  Cd Length: 41  Bit Score: 54.05  E-value: 3.33e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1238321544  81 VKINPTDVEIIANELELDKKIAERTLREHKGDAVAAVRFLL 121
Cdd:cd14361     1 VKVKKEDVELIVNELEVSKAQAERALREHNGDVVKALRALI 41
 
Name Accession Description Interval E-value
HYPK_UBA pfam19026
HYPK UBA domain; This entry represents the UBA domain found at the C-terminus of the HYPK ...
 81-121 2.57e-11

HYPK UBA domain; This entry represents the UBA domain found at the C-terminus of the HYPK protein and its homologs. This domain in HYPK mediates a protein interaction with the Naa15 C-terminus.


Pssm-ID: 436907  Cd Length: 41  Bit Score: 54.10  E-value: 2.57e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1238321544  81 VKINPTDVEIIANELELDKKIAERTLREHKGDAVAAVRFLL 121
Cdd:pfam19026   1 VKVKKEDVELIMTELEVSKAKAERALREHGGDVVAALRALL 41
UBA_HYPK cd14361
UBA-like domain found in Huntingtin-interacting protein K (HYPK) and similar proteins; HYPK, ...
 81-121 3.33e-11

UBA-like domain found in Huntingtin-interacting protein K (HYPK) and similar proteins; HYPK, also called Huntingtin yeast partner K or Huntingtin yeast two-hybrid protein K, is an intrinsically unstructured Huntingtin (HTT)-interacting protein with chaperone-like activity. It is involved in regulating cell growth, cell cycle, unfolded protein response, and cell death. All members in this subfamily contain an N-terminal ubiquitin-associated (UBA) that shows high sequence similarity with that of eukaryotic nascent polypeptide-associated complex proteins (NAC) which is one of the cytosolic chaperones that contact the nascent polypeptide chains as they emerge from the ribosome and assist in post-translational processes.


Pssm-ID: 270544  Cd Length: 41  Bit Score: 54.05  E-value: 3.33e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1238321544  81 VKINPTDVEIIANELELDKKIAERTLREHKGDAVAAVRFLL 121
Cdd:cd14361     1 VKVKKEDVELIVNELEVSKAQAERALREHNGDVVKALRALI 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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