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Conserved domains on  [gi|2494674|sp|P56091|]
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RecName: Full=Galactokinase; AltName: Full=Galactose kinase

Protein Classification

galactokinase family protein( domain architecture ID 1004942)

galactokinase family protein such as galactokinase that catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  1.20.1440.340|3.30.230.10|3.30.70.3170
EC:  2.7.1.-
Gene Ontology:  GO:0005524|GO:0004335|GO:0005975
PubMed:  26862196|15526155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02521 super family cl33510
galactokinase
 2-510 1.44e-105

galactokinase


The actual alignment was detected with superfamily member PLN02521:

Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 324.74  E-value: 1.44e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674     2 SVPTFDDLS-FYSNDQEL--TKSRYLKLVEIFQSNFpNASIDFFARSPGRVNLIGDHIDYNFFPVLPMAISADVIVAVNV 78
Cdd:PLN02521   8 PVPVFSSLEpVYGDGSLLeeARLRYARLKAAFVEVY-GAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    79 NDE-PEIVITHTDSKnFAKETIPLTNNNdgfEIDSQHHSWANYFKCALIVANNYLTEQN-LKGQLKGMKLTFDGNVPTGG 156
Cdd:PLN02521  87 AEGsKKLRIANVNDK-YTTCTFPADPDQ---EVDLANHKWGNYFICGYKGVFEFLKSKGvDVGPPVGLDVVVDGTVPTGS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   157 GLSSSAAFCVASTLAILHANGVkDITKADLTRITVVCEHYVGVNTGGMDQCASVYGEPDKALLIQFKPkLIGKPFKFPvE 236
Cdd:PLN02521 163 GLSSSAALVCSAAIAIMAALGL-NFTKKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNP-VRATDVQLP-A 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   237 NLTFVITNSLQVSNKHETAPIHYNLRVVEMAIAADVLVKKLNLGtlvPQDSNIGTSSLRGVMDAVFN-TCKWDGNDIDVG 315
Cdd:PLN02521 240 GGTFVIANSLAESNKAVTAATNYNNRVVECRLAAIVLAVKLGMS---AEEAISKVKTLSDVEGLCVSfAGSHGSSDPAVA 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   316 IDQLKKmiaivetelnnnQEGYTVDQCLTVLDLSLDE-FKSKylqayPVKFDVL------KLYQRAKHVYQESLRVLEtl 388
Cdd:PLN02521 317 VKELLH------------EGPYTAEEIEEILGESLTSiFKNS-----PTSLAVLkaakhfKLHQRAVHVYSEAKRVHA-- 377

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   389 kllstTQTSSNSKDDDESFLVKFGELMNQSQSDLDKLNESSNDKLNKICSIALQNGSYGSRITGAGWGGSIVHLTTLDKS 468
Cdd:PLN02521 378 -----FRDTVSSSLSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARLTGAGWGGCAVALVKEAIV 452

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....
gi 2494674   469 KQLIQGLIKNYYQ--LEFPSIKLDElLNDAIIDSKPSMGSCIVT 510
Cdd:PLN02521 453 PQFILALKEKFYKsrIEKGVIKEED-LGLYVFASKPSSGAAILK 495
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 2-510 1.44e-105

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 324.74  E-value: 1.44e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674     2 SVPTFDDLS-FYSNDQEL--TKSRYLKLVEIFQSNFpNASIDFFARSPGRVNLIGDHIDYNFFPVLPMAISADVIVAVNV 78
Cdd:PLN02521   8 PVPVFSSLEpVYGDGSLLeeARLRYARLKAAFVEVY-GAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    79 NDE-PEIVITHTDSKnFAKETIPLTNNNdgfEIDSQHHSWANYFKCALIVANNYLTEQN-LKGQLKGMKLTFDGNVPTGG 156
Cdd:PLN02521  87 AEGsKKLRIANVNDK-YTTCTFPADPDQ---EVDLANHKWGNYFICGYKGVFEFLKSKGvDVGPPVGLDVVVDGTVPTGS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   157 GLSSSAAFCVASTLAILHANGVkDITKADLTRITVVCEHYVGVNTGGMDQCASVYGEPDKALLIQFKPkLIGKPFKFPvE 236
Cdd:PLN02521 163 GLSSSAALVCSAAIAIMAALGL-NFTKKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNP-VRATDVQLP-A 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   237 NLTFVITNSLQVSNKHETAPIHYNLRVVEMAIAADVLVKKLNLGtlvPQDSNIGTSSLRGVMDAVFN-TCKWDGNDIDVG 315
Cdd:PLN02521 240 GGTFVIANSLAESNKAVTAATNYNNRVVECRLAAIVLAVKLGMS---AEEAISKVKTLSDVEGLCVSfAGSHGSSDPAVA 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   316 IDQLKKmiaivetelnnnQEGYTVDQCLTVLDLSLDE-FKSKylqayPVKFDVL------KLYQRAKHVYQESLRVLEtl 388
Cdd:PLN02521 317 VKELLH------------EGPYTAEEIEEILGESLTSiFKNS-----PTSLAVLkaakhfKLHQRAVHVYSEAKRVHA-- 377

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   389 kllstTQTSSNSKDDDESFLVKFGELMNQSQSDLDKLNESSNDKLNKICSIALQNGSYGSRITGAGWGGSIVHLTTLDKS 468
Cdd:PLN02521 378 -----FRDTVSSSLSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARLTGAGWGGCAVALVKEAIV 452

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....
gi 2494674   469 KQLIQGLIKNYYQ--LEFPSIKLDElLNDAIIDSKPSMGSCIVT 510
Cdd:PLN02521 453 PQFILALKEKFYKsrIEKGVIKEED-LGLYVFASKPSSGAAILK 495
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 24-507 9.06e-96

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 295.58  E-value: 9.06e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674     24 LKLVEIFQSNFPNASiDFFARSPGRVNLIGDHIDYNFFPVLPMAISADVIVAVNVNDEPEIVITHTDSKNFAKEtipltn 103
Cdd:TIGR00131   2 ESIQKIFASAFGAKP-DFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADNKFAE------ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    104 nndgFEID-----SQHHSWANYFKCALIVANnyltEQNLKGQLkGMKLTFDGNVPTGGGLSSSAAFCVASTLAILHANGV 178
Cdd:TIGR00131  75 ----RSLDlpldgSEVSDWANYFKGVLHVAQ----ERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHL 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    179 KDITKADLTRITVVCEHYVGVNTGGMDQCASVYGEPDKALLIQFKpKLIGKPFKFPVENLTFVITNSLQvsnKHETAPIH 258
Cdd:TIGR00131 146 PLDSKQILLRIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECR-SLKATPFKFPQLGIAFVIANTNV---KRTLAPSN 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    259 YNLRVVEMAIAADVLVKKlnlgtlvpqdsNIGtsSLRGVMDAVFNTckwdgndidvGIDQLKKMIAIVEtelnnnqegyt 338
Cdd:TIGR00131 222 YNTRRQECTTAANFLAAT-----------DKG--ALRDFMNEYFAR----------YIARLTKMLPLVE----------- 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    339 vdqcltvldlsldefkskylqaypvkfdvlklyQRAKHVYQESLRVLETLKLLsttqtssnsKDDDesfLVKFGELMNQS 418
Cdd:TIGR00131 268 ---------------------------------ERAKHVVSENLRVLKAVKAM---------KDND---FKQFGALMNES 302

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    419 QSDLDKLNESSNDKLN-KICSIALQNGSYGSRITGAGWGGSIVHLTTLDKSKQLIQGLIKNYYQlefpsiKLDELLNDAI 497
Cdd:TIGR00131 303 HASCDDDYECTCPEIDeLVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPK------KTGLELTFYV 376

                         490
                  ....*....|
gi 2494674    498 IDSKPSMGSC 507
Cdd:TIGR00131 377 IVSKPGAGSC 386
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
22-481 6.97e-76

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 243.91  E-value: 6.97e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   22 RYLKLVEIFQSNFPNASIDFFaRSPGRVNLIGDHIDYNFFPVLPMAISADVIVAVNVNDEPEIVIThtdSKNFAKE-TIP 100
Cdd:COG0153   1 RLERLIEAFEEAFGEEPEGVF-SAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVY---SADFDEEvEFD 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674  101 LtnnnDGFEIDSQHHsWANYFK--CALIVANNYlteqnlkgQLKGMKLTFDGNVPTGGGLSSSAAFCVASTLAILHANGV 178
Cdd:COG0153  77 L----DDLEPGEEDG-WANYVRgvAWALQERGY--------KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGL 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674  179 kDITKADLTRITVVCEH-YVGVNTGGMDQCASVYGEPDKALLIQFKPkLIGKPFKFPVENLTFVITNSlQVsnKHETAPI 257
Cdd:COG0153 144 -GLDPVELAKIGQRAENeFVGVPCGIMDQFASALGKKGHALLLDCRS-LEYEYVPLPLEGYALVIVDT-NV--KHSLADS 218

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674  258 HYNLRVVEMAIAADVLvkklnlgtlvpqdsniGTSSLRgvmdavfntckwdgndiDVGIDQLKKMIAIVETELnnnqegy 337
Cdd:COG0153 219 EYNERRAECEAAAAIL----------------GVKSLR-----------------DVTLEDLEAARARLGDEV------- 258

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674  338 tvdqcltvldlsldefkskylqaypvkfdvlkLYQRAKHVYQESLRVLETLKLLsttqtssnsKDDDesfLVKFGELMNQ 417
Cdd:COG0153 259 --------------------------------LRRRARHVVTENQRVLEAVEAL---------RAGD---LEAFGKLMNA 294

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2494674  418 SQSDLDKLNESSNDKLNKICSIAL-QNGSYGSRITGAGWGGSIVHLTTLDKSKQLIQGLIKNYYQ 481
Cdd:COG0153 295 SHASLRDDYEVSCPELDTLVELALaEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAE 359
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 28-76 5.47e-18

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 77.49  E-value: 5.47e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2494674     28 EIFQSNFpNASIDFFARSPGRVNLIGDHIDYNFFPVLPMAISADVIVAV 76
Cdd:pfam10509   1 EAFEELF-GKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAV 48
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 2-510 1.44e-105

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 324.74  E-value: 1.44e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674     2 SVPTFDDLS-FYSNDQEL--TKSRYLKLVEIFQSNFpNASIDFFARSPGRVNLIGDHIDYNFFPVLPMAISADVIVAVNV 78
Cdd:PLN02521   8 PVPVFSSLEpVYGDGSLLeeARLRYARLKAAFVEVY-GAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    79 NDE-PEIVITHTDSKnFAKETIPLTNNNdgfEIDSQHHSWANYFKCALIVANNYLTEQN-LKGQLKGMKLTFDGNVPTGG 156
Cdd:PLN02521  87 AEGsKKLRIANVNDK-YTTCTFPADPDQ---EVDLANHKWGNYFICGYKGVFEFLKSKGvDVGPPVGLDVVVDGTVPTGS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   157 GLSSSAAFCVASTLAILHANGVkDITKADLTRITVVCEHYVGVNTGGMDQCASVYGEPDKALLIQFKPkLIGKPFKFPvE 236
Cdd:PLN02521 163 GLSSSAALVCSAAIAIMAALGL-NFTKKEVAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNP-VRATDVQLP-A 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   237 NLTFVITNSLQVSNKHETAPIHYNLRVVEMAIAADVLVKKLNLGtlvPQDSNIGTSSLRGVMDAVFN-TCKWDGNDIDVG 315
Cdd:PLN02521 240 GGTFVIANSLAESNKAVTAATNYNNRVVECRLAAIVLAVKLGMS---AEEAISKVKTLSDVEGLCVSfAGSHGSSDPAVA 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   316 IDQLKKmiaivetelnnnQEGYTVDQCLTVLDLSLDE-FKSKylqayPVKFDVL------KLYQRAKHVYQESLRVLEtl 388
Cdd:PLN02521 317 VKELLH------------EGPYTAEEIEEILGESLTSiFKNS-----PTSLAVLkaakhfKLHQRAVHVYSEAKRVHA-- 377

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   389 kllstTQTSSNSKDDDESFLVKFGELMNQSQSDLDKLNESSNDKLNKICSIALQNGSYGSRITGAGWGGSIVHLTTLDKS 468
Cdd:PLN02521 378 -----FRDTVSSSLSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARLTGAGWGGCAVALVKEAIV 452

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....
gi 2494674   469 KQLIQGLIKNYYQ--LEFPSIKLDElLNDAIIDSKPSMGSCIVT 510
Cdd:PLN02521 453 PQFILALKEKFYKsrIEKGVIKEED-LGLYVFASKPSSGAAILK 495
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 24-507 9.06e-96

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 295.58  E-value: 9.06e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674     24 LKLVEIFQSNFPNASiDFFARSPGRVNLIGDHIDYNFFPVLPMAISADVIVAVNVNDEPEIVITHTDSKNFAKEtipltn 103
Cdd:TIGR00131   2 ESIQKIFASAFGAKP-DFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADNKFAE------ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    104 nndgFEID-----SQHHSWANYFKCALIVANnyltEQNLKGQLkGMKLTFDGNVPTGGGLSSSAAFCVASTLAILHANGV 178
Cdd:TIGR00131  75 ----RSLDlpldgSEVSDWANYFKGVLHVAQ----ERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHL 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    179 KDITKADLTRITVVCEHYVGVNTGGMDQCASVYGEPDKALLIQFKpKLIGKPFKFPVENLTFVITNSLQvsnKHETAPIH 258
Cdd:TIGR00131 146 PLDSKQILLRIQVAENHFVGVNCGIMDQAASVLGKEDHALLVECR-SLKATPFKFPQLGIAFVIANTNV---KRTLAPSN 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    259 YNLRVVEMAIAADVLVKKlnlgtlvpqdsNIGtsSLRGVMDAVFNTckwdgndidvGIDQLKKMIAIVEtelnnnqegyt 338
Cdd:TIGR00131 222 YNTRRQECTTAANFLAAT-----------DKG--ALRDFMNEYFAR----------YIARLTKMLPLVE----------- 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    339 vdqcltvldlsldefkskylqaypvkfdvlklyQRAKHVYQESLRVLETLKLLsttqtssnsKDDDesfLVKFGELMNQS 418
Cdd:TIGR00131 268 ---------------------------------ERAKHVVSENLRVLKAVKAM---------KDND---FKQFGALMNES 302

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    419 QSDLDKLNESSNDKLN-KICSIALQNGSYGSRITGAGWGGSIVHLTTLDKSKQLIQGLIKNYYQlefpsiKLDELLNDAI 497
Cdd:TIGR00131 303 HASCDDDYECTCPEIDeLVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPK------KTGLELTFYV 376

                         490
                  ....*....|
gi 2494674    498 IDSKPSMGSC 507
Cdd:TIGR00131 377 IVSKPGAGSC 386
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
22-481 6.97e-76

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 243.91  E-value: 6.97e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   22 RYLKLVEIFQSNFPNASIDFFaRSPGRVNLIGDHIDYNFFPVLPMAISADVIVAVNVNDEPEIVIThtdSKNFAKE-TIP 100
Cdd:COG0153   1 RLERLIEAFEEAFGEEPEGVF-SAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVY---SADFDEEvEFD 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674  101 LtnnnDGFEIDSQHHsWANYFK--CALIVANNYlteqnlkgQLKGMKLTFDGNVPTGGGLSSSAAFCVASTLAILHANGV 178
Cdd:COG0153  77 L----DDLEPGEEDG-WANYVRgvAWALQERGY--------KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGL 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674  179 kDITKADLTRITVVCEH-YVGVNTGGMDQCASVYGEPDKALLIQFKPkLIGKPFKFPVENLTFVITNSlQVsnKHETAPI 257
Cdd:COG0153 144 -GLDPVELAKIGQRAENeFVGVPCGIMDQFASALGKKGHALLLDCRS-LEYEYVPLPLEGYALVIVDT-NV--KHSLADS 218

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674  258 HYNLRVVEMAIAADVLvkklnlgtlvpqdsniGTSSLRgvmdavfntckwdgndiDVGIDQLKKMIAIVETELnnnqegy 337
Cdd:COG0153 219 EYNERRAECEAAAAIL----------------GVKSLR-----------------DVTLEDLEAARARLGDEV------- 258

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674  338 tvdqcltvldlsldefkskylqaypvkfdvlkLYQRAKHVYQESLRVLETLKLLsttqtssnsKDDDesfLVKFGELMNQ 417
Cdd:COG0153 259 --------------------------------LRRRARHVVTENQRVLEAVEAL---------RAGD---LEAFGKLMNA 294

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2494674  418 SQSDLDKLNESSNDKLNKICSIAL-QNGSYGSRITGAGWGGSIVHLTTLDKSKQLIQGLIKNYYQ 481
Cdd:COG0153 295 SHASLRDDYEVSCPELDTLVELALaEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAE 359
PRK05322 PRK05322
galactokinase; Provisional
 25-479 7.42e-41

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 151.16  E-value: 7.42e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    25 KLVEIFQSNFPNASIDFFArSPGRVNLIGDHIDYNFFPVLPMAISADVIVAVNVNDEPEIvitHTDSKNFAKETI-PLTN 103
Cdd:PRK05322   5 ELKKKFAEVFGEEAEDVFF-SPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKV---RLYSANFEDLGIiEFDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   104 NNDGFEidsQHHSWANYFKCALivanNYLTEQNLKGQlKGMKLTFDGNVPTGGGLSSSAAfcvastLAILHANGVKDITK 183
Cdd:PRK05322  81 DDLSFD---KEDDWANYPKGVL----KFLQEAGYKID-HGFDILIYGNIPNGAGLSSSAS------IELLTGVILKDLFN 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   184 ADLTRITVV-----CE-HYVGVNTGGMDQCASVYGEPDKALLIQ---FKPKLIgkPFKFpvENLTFVITNslqvSNK-HE 253
Cdd:PRK05322 147 LDLDRLELVklgqkTEnEFIGVNSGIMDQFAIGMGKKDHAILLDcntLEYEYV--PLDL--GDYVIVIMN----TNKrRE 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   254 TAPIHYNLRVVEMAIAADVLVKKLNLGTLvpqdsniGtsslrgvmdavfntckwdgndidvgidqlkkmiaivetelnnn 333
Cdd:PRK05322 219 LADSKYNERRAECEKALEELQKKLDIKSL-------G------------------------------------------- 248

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   334 qegytvdqcltvlDLSLDEF-KSKYLQAYPVkfdvlkLYQRAKHVYQESLRVLETLKLLsttqtssnsKDDDesfLVKFG 412
Cdd:PRK05322 249 -------------ELTEEEFdEYSYLIKDET------LLKRARHAVTENQRTLKAVKAL---------KAGD---LEKFG 297

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2494674   413 ELMNQSQSDLDKLNESSNDKLNKICSIAL-QNGSYGSRITGAGWGGSIVHLTTLDKSKQLIQGLIKNY 479
Cdd:PRK05322 298 RLMNASHVSLRDDYEVTGLELDTLVEAAWkQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAY 365
PRK03817 PRK03817
galactokinase; Provisional
 44-485 1.46e-40

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 149.38  E-value: 1.46e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    44 RSPGRVNLIGDHIDYNFFPVLPMAISADVIVAVNVNDEPEIVithtdSKNFAKETipltnnndGFEIDS--QHHSWANYF 121
Cdd:PRK03817   4 KSPGRVNLIGEHTDYNDGYVLPFAINLYTFLEIEKSEKFIFY-----SENFNEEK--------TFELDKleKLNSWADYI 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   122 K--CALIVANNYlteqnlkgQLKGMKLTFDGNVPTGGGLSSSAAFCVASTLAILHANGVkDITKADLTRITVVCEH-YVG 198
Cdd:PRK03817  71 KgvIWVLEKRGY--------EVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNL-NLSKLELALLAREAENeFVG 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   199 VNTGGMDQCASVYGEPDKALLIQFKpKLIGKPFKFPvENLTFVITNSlqvSNKHETAPIHYNLR--VVEMAIAAdvlvkk 276
Cdd:PRK03817 142 VPCGIMDQFAVAFGKKDHAIFLDTM-TLEYEYVPFP-EDYEILVFDT---GVKRELASSEYNERrqECEEALKI------ 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   277 lnlgtlvpqdsnIGTSSLRGVmdavfntckwdgndidvgidqlkkmiaiVETELNNnqegytvdqcltvldlsLDEFKSK 356
Cdd:PRK03817 211 ------------LGKKSSKEV----------------------------TEEDLSK-----------------LPPLLRK 233

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   357 ylqaypvkfdvlklyqRAKHVYQESLRVLETLKLLsttqtssnsKDDDesfLVKFGELMNQSQSDLDKLNESSNDKLNKI 436
Cdd:PRK03817 234 ----------------RAGYVLRENERVLKVRDAL---------KEGD---IETLGELLTESHWDLADNYEVSCEELDFF 285

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 2494674   437 CSIALQNGSYGSRITGAGWGGSIVHLTTLDKSKQLIQGLIKNYYQLeFP 485
Cdd:PRK03817 286 VEFALELGAYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYKKR-FG 333
PRK05101 PRK05101
galactokinase; Provisional
 29-481 2.79e-34

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 133.12  E-value: 2.79e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    29 IFQSNFPNASiDFFARSPGRVNLIGDHIDYNFFPVLPMAISADVIVAVNVNDEPEIVITHTDsknfaketipLTNNNDGF 108
Cdd:PRK05101  10 LFAQQFGYPP-THTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIAAD----------YDNQQDEF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   109 EIDS-----QHHSWANYFKCALIvannYLTEQNLkgQLKGMKLTFDGNVPTGGGLSSSAAFCVASTLAILHANGVkDITK 183
Cdd:PRK05101  79 SLDApivphPEQQWANYVRGVVK----HLQERNP--DFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHL-PLSG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   184 ADLTRITVVCEH-YVGVNTGGMDQCASVYGEPDKALLIQFKpKLIGKPFKFPvENLTFVITNslqvSN-KHETAPIHYNL 261
Cdd:PRK05101 152 AEIALNGQEAENqFVGCNCGIMDQLISALGKKDHALLIDCR-SLETKAVPMP-EGVAVVIIN----SNvKRGLVDSEYNT 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   262 RVVEMAIAADVLvkklnlgtlvpqdsniGTSSLRgvmdavfntckwdgndidvgidqlkkmiaivetelnnnqegytvdq 341
Cdd:PRK05101 226 RRQQCETAARFF----------------GVKALR---------------------------------------------- 243

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   342 cltvlDLSLDEFKSKYLQAYPVkfdvlkLYQRAKHVYQESLRVLETLKLLsttqtssNSKDddesfLVKFGELMNQSQ-- 419
Cdd:PRK05101 244 -----DVTLEQFNAVAAELDPV------VAKRARHVITENARTLEAASAL-------AAGD-----LKRMGELMAESHas 300

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2494674   420 ---------SDLDKLNESSNDKLNKicsialqNGsyGSRITGAGWGGSIVHLTTLDKSKQLIQGLIKNYYQ 481
Cdd:PRK05101 301 mrddfeitvPQIDTLVEIVKAVIGD-------QG--GVRMTGGGFGGCIVALVPEELVEAVRQAVAEQYEA 362
PRK00555 PRK00555
galactokinase; Provisional
 45-485 8.44e-28

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 114.19  E-value: 8.44e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    45 SPGRVNLIGDHIDYNFFPVLPMAISADVIVAVnvndEPEI--VITHTDSKNFAKETIPLTNNNDGFEidsqhhSWANYfk 122
Cdd:PRK00555   7 APGRINLIGEHTDYNLGFALPIALPQRTVVTF----TPEHtdAITASSDRADGSARIPLDTTPGQVT------GWAAY-- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   123 caliVANNYLTEQNLKGQLKGMKLTFDGNVPTGGGLSSSAAFCVASTLAILHANGVkDITKADLTRITVVCEH-YVGVNT 201
Cdd:PRK00555  75 ----AAGVIWALRGAGHPVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATGT-RIDRLEQARLAQRAENeYVGAPT 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   202 GGMDQCASVYGEPDKALLIQFKPKLIGK-PFKFPVENLTFVITNSlqvSNKHETAPIHYNLRVVEMAIAAdvlvkklnlg 280
Cdd:PRK00555 150 GLLDQLAALFGAPKTALLIDFRDLTVRPvAFDPDAAGVVLLLMDS---RARHRHAGGEYAARRASCERAA---------- 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   281 tlvpqdSNIGTSSLRGVMdavfntckwdgndidvgidqlkkmiaivetelnnnqegytvDQCLTVLDLSLDefkskylqa 360
Cdd:PRK00555 217 ------ADLGVSSLRAVQ-----------------------------------------DRGLAALGAIAD--------- 240

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   361 yPVKFdvlklyQRAKHVYQESLRVLETLKLLSttqtssnskdddESFLVKFGELMNQSQSDLDKLNESSNDKLNKICSIA 440
Cdd:PRK00555 241 -PIDA------RRARHVLTENQRVLDFAAALA------------DSDFTAAGQLLTASHASMRDDFEITTERIDLIADSA 301

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 2494674   441 LQNGSYGSRITGAGWGGSIVHLTTLDKSKQLIQGLIKNYYQLEFP 485
Cdd:PRK00555 302 VRAGALGARMTGGGFGGCVIALVPADRAEDVADTVRRAAVTAGYP 346
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 45-463 6.18e-21

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 92.60  E-value: 6.18e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   45 SPGRVNLIGDHIDYNFFPVLPMAISADVIVAVNVNDEPEIVITHTDsknfaketipltnNNDGFEIDSQHHSWANYFKCA 124
Cdd:COG1577   1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKLRIESPD-------------LGGTLDLDPLADAALRYIKAA 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674  125 LivannYLTEQNLKGQLKGMKLTFDGNVPTGGGLSSSAAFCVASTLAILHANGVkDITKADLTRITVVCEHYVGVNTGGM 204
Cdd:COG1577  68 I-----EAALEYLGLPLKGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFYGV-ELSKEELFKLALEAEKIVHGNPSGL 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674  205 DQCASVYGEPdkallIQFKPKLIGKPFKFPvENLTFVITNSlqvsnkhetapihynlrvvemaiaadvlvkklnlgtlvp 284
Cdd:COG1577 142 DTAASTYGGP-----IYYQRGDRAEPLELP-KNLPLVVGDT--------------------------------------- 176

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674  285 qdsniGTSSlrgvmdavfNTckwdgndidvgidqlKKMIAIVETELNNNQEGYTvdqcltvldlsldefkskylqaypvk 364
Cdd:COG1577 177 -----GVPA---------ST---------------KELVAKVRKLKERNPELYE-------------------------- 201

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674  365 fdvlKLYQRAKHVYQESLRVLETlkllsttqtssnsKDddesfLVKFGELMNQSQSDLDKLNESSnDKLNKICSIALQNG 444
Cdd:COG1577 202 ----AFLEEIGDLVEEAIEALEE-------------GD-----LEALGELMNENHGLLRALGVST-PELDRLVEAARKAG 258

                       410
                ....*....|....*....
gi 2494674  445 SYGSRITGAGWGGSIVHLT 463
Cdd:COG1577 259 ALGAKLTGAGGGGCVIALA 277
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 28-76 5.47e-18

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 77.49  E-value: 5.47e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2494674     28 EIFQSNFpNASIDFFARSPGRVNLIGDHIDYNFFPVLPMAISADVIVAV 76
Cdd:pfam10509   1 EAFEELF-GKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAV 48
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 45-462 6.88e-15

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 75.02  E-value: 6.88e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674     45 SPGRVNLIGDH-IDYNFfPVLPMAISADVIVAVNVNdepeivithtdSKNFAKETIPLTNNNDGFEIDSQHHswanyfKC 123
Cdd:TIGR00549   1 APGKIILFGEHaVVYGE-PAIAAPIPLRTTVTVIES-----------SDGSFIESDLGRGSLDDAPDELDGL------KY 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    124 ALIVANNYLTEQNLKGqlkgMKLTFDGNVPTGGGLSSSAAFCVASTLAILHANGVkDITKADLTRITVVCEHYVGVNTGG 203
Cdd:TIGR00549  63 VLAEFLSRFSELNPPP----LEITIESEIPPGRGLGSSAAVAVALIRALADYFGS-ELSKEELAELANEAEKIAHGKPSG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    204 MDQCASVYGEPdkaLLIQ----FKPKLIGKPfkfpvenLTFVITNSlQVSnkHETApihynlRVVEMaiaadvlVKKLnl 279
Cdd:TIGR00549 138 IDTATSTSGGP---VYFEkgegEFTKLISLD-------GYFVIADT-GVS--GSTK------EAVAR-------VRQL-- 189

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    280 gtlvpqdsnigTSSLRGVMDAVFNTckwdgndidvgIDQLKKmiaivetelnnnqegytvdqcltvldlsldefkskylq 359
Cdd:TIGR00549 190 -----------LERFPELIDSIMDA-----------IGELTL-------------------------------------- 209

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    360 aypvkfdvlklyqRAKHVYQeslrvletlkllsttqtssnskDDDESFLvkfGELMNQSQSDLDKLNeSSNDKLNKICSI 439
Cdd:TIGR00549 210 -------------EAKAALQ----------------------DGDVESL---GELMNINQGLLKALG-VSHPKLDQLVEI 250

                         410       420
                  ....*....|....*....|...
gi 2494674    440 ALQNGSYGSRITGAGWGGSIVHL 462
Cdd:TIGR00549 251 ARKAGALGAKLTGAGGGGCMIAL 273
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 145-213 1.16e-14

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 68.34  E-value: 1.16e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    145 KLTFDGNVPTGGGLSSSAAFCVASTLAILHANGVkditkaDLTRITVVCEHYV-GVNTGGMDQCASVYGE 213
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFGL------PLAKLALEAEELAgGGRGGGMDVAASLYGG 64
PTZ00290 PTZ00290
galactokinase; Provisional
 42-462 2.10e-13

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 72.16  E-value: 2.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    42 FARSPGRVNLIGDHIDYNFFPVLPMAisadvivavnVNDEPEIVITHTdsKNFAKETIPL-TNNNDGFEID----SQHH- 115
Cdd:PTZ00290  39 FTFAPGRVNFIGEHVDYMGGYVCPAA----------VLEGCHILVGRV--KHFCDHKLRFaTETDEHFVLDhlggAKHNk 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   116 SWANYFKCALIVANNYLTEQNLKGQLKGMKLTFDGNVPTGGGLSSSAAFCVastlAILHA-NGV-----KDITKADLTRI 189
Cdd:PTZ00290 107 AWTTFVRGAATLRLNRLGVAIDAPSLQGVCMVVHGTLPMGAGMSASASFGV----ALLNAiNTVvtrryKGCPTSPGRRY 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   190 TVV--CEH----------------YVGVNTGGMDQCASVYGEPDKALLIQFKpkligkpfkfpveNLTFvitnslqvsnk 251
Cdd:PTZ00290 183 SILppMSKeelielakqarrieteFCGVNVGIMDQFISAFAEEDKFMFLDCK-------------SLTF----------- 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   252 hETAPIHYNLRVVEMAIAADVLVKKLNLGtlvpqdsniGTSSLrgvmdavFNTCKWDGNDIDVGI-DQLKKMIAIVETEL 330
Cdd:PTZ00290 239 -ESHDMTPLLGDGACFLLIDSMIKHDLLG---------GTAGM-------YNTVRSDQEGAQKKIgKHRYRGKPFTFSDL 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   331 NNNQEGYTVDQCLTVLdlsLDEFKSkylQAYPVKFDvlklyqRAKHVYQESLRVLETLKLLSTTQTSSNskdddESFLVK 410
Cdd:PTZ00290 302 VRNPKKYTFDGDVVAF---MESCKP---LMTPGEFE------RGTYNIMEQIRTLEFIKLNDPELPLSR-----EERFRK 364

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 2494674   411 FGELMNQSQSDLDKLNESSNDKLNKIC-SIALQNGSYGSRITGAGWGGSIVHL 462
Cdd:PTZ00290 365 AGEILNAGHQGMRDLMKITTPELDFIHeLINEEKGVAGGRMMGGGFGGCIILL 417
PLN02865 PLN02865
galactokinase
 42-275 4.25e-10

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 61.74  E-value: 4.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    42 FARSPGRVNLIGDHIDYNFFPVLPMAISADVIVAVNVNDEPEIVIThtdSKNFAKETipltnnndGFEIDSQHHS----- 116
Cdd:PLN02865  32 VVVSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLR---SAQFEGEV--------RFRVDEIQHPianvs 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   117 --------WANYFKCALIVANN--YLTEQNLKGQLKGMKlTFDGnvptgGGLSSSAAFCVASTLAILHANGVKdITKADL 186
Cdd:PLN02865 101 sdskeesnWGDYARGAVYALQSrgHALSQGITGYISGSE-GLDS-----SGLSSSAAVGVAYLLALENANNLT-VSPEDN 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   187 TRITVVCEH-YVGVNTGGMDQCASVYGEPDKALLIQFK---PKLIGKPFKFPVENLTFVITNSLQVSNKHETAPIHYNLR 262
Cdd:PLN02865 174 IELDRLIENeYLGLRNGILDQSAILLSRYGCLTFMDCKtldHKLVSLQFQQPGGEKPFKILLAFSGLRHALTNKPGYNLR 253

                        250
                 ....*....|...
gi 2494674   263 VVEMAIAADVLVK 275
Cdd:PLN02865 254 VSECQEAARFLLE 266
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 405-481 2.13e-08

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 51.32  E-value: 2.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674    405 ESFLVKFGELMNQSQSDLDKLNE--SSNDKLNKICSIALQNGsYGSRITGAGWGGSIVHLT-TLDKSKQLIQGLIKNYYQ 481
Cdd:pfam08544   7 RGDLEELGKLLTESAESLEPLLVvgILPPELDELLEALLELG-LGAKLSGSGGGPTVFALFkDEDDAEEVARALREAGKK 85
PRK03926 PRK03926
mevalonate kinase; Provisional
 367-470 3.20e-07

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 51.98  E-value: 3.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   367 VLKLYQRAKHVYQEslrVLETLKLLSTTQTSSNSKDDdesfLVKFGELMNQSQSDLDKLNESSNdKLNKICSIALQNGSY 446
Cdd:PRK03926 179 VRKLKEEYPELIEP---ILSSIGKISEKGEELILSGD----YVSLGELMNINQGLLDALGVSTK-ELSELIYAARTAGAL 250

                         90       100
                 ....*....|....*....|....
gi 2494674   447 GSRITGAGWGGSIVHLTTLDKSKQ 470
Cdd:PRK03926 251 GAKITGAGGGGCMVALAAPEKQSE 274
PLN02677 PLN02677
mevalonate kinase
 145-230 6.49e-03

mevalonate kinase


Pssm-ID: 215363 [Multi-domain]  Cd Length: 387  Bit Score: 39.04  E-value: 6.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2494674   145 KLTFDGNVPTGGGLSSSAAFCVASTLAILHANGVkditkadltritvvcehyVGVNTGGMDQcaSVYGEPDKALLIQFK- 223
Cdd:PLN02677 131 TVVVTSELPLGSGLGSSAAFCVALSAALLAASDS------------------ISVSTGGNGW--SSLDETDLELVNKWAf 190

                         90
                 ....*....|
gi 2494674   224 --PKLI-GKP 230
Cdd:PLN02677 191 egEKIIhGKP 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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