NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1679353681|sp|P32760|]
View 

RecName: Full=Pleiotrophin; Short=PTN; AltName: Full=Heparin-binding brain mitogen; Short=HBBM; AltName: Full=Heparin-binding growth factor 8; Short=HBGF-8; AltName: Full=Heparin-binding growth-associated molecule; Short=HB-GAM; AltName: Full=Heparin-binding neutrophic factor; Short=HBNF; AltName: Full=Osteoblast-specific factor 1; Short=OSF-1; Flags: Precursor

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PTN_MK_N super family cl02505
PTN/MK heparin-binding protein family, N-terminal domain;
45-129 8.17e-44

PTN/MK heparin-binding protein family, N-terminal domain;


The actual alignment was detected with superfamily member smart00193:

Pssm-ID: 470593  Cd Length: 80  Bit Score: 139.63  E-value: 8.17e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679353681   45 CGEWQWSVCVPTNGDCGLGTREGTrtgaeCKQTTKTQKCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTGNLKRAL 124
Cdd:smart00193   1 CGEWQWGPCIPNSKDCGLGTREGT-----CGQETRKLKCKIPCNWKKQFGADCKYKFESWGECDANTGLKTRSGTLKKAL 75


                   ....*
gi 1679353681  125 HNADC 129
Cdd:smart00193  76 YNADC 80
 
Name Accession Description Interval E-value
PTN smart00193
Pleiotrophin / midkine family; Heparin-binding domain family.
 45-129 8.17e-44

Pleiotrophin / midkine family; Heparin-binding domain family.


Pssm-ID: 128490  Cd Length: 80  Bit Score: 139.63  E-value: 8.17e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679353681   45 CGEWQWSVCVPTNGDCGLGTREGTrtgaeCKQTTKTQKCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTGNLKRAL 124
Cdd:smart00193   1 CGEWQWGPCIPNSKDCGLGTREGT-----CGQETRKLKCKIPCNWKKQFGADCKYKFESWGECDANTGLKTRSGTLKKAL 75


                   ....*
gi 1679353681  125 HNADC 129
Cdd:smart00193  76 YNADC 80
PTN_MK_N pfam05196
PTN/MK heparin-binding protein family, N-terminal domain;
43-93 1.12e-23

PTN/MK heparin-binding protein family, N-terminal domain;


Pssm-ID: 461582  Cd Length: 57  Bit Score: 87.51  E-value: 1.12e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1679353681  43 SDCGEWQWSVCVPTNGDCGLGTREGTrtgaeCKQTTKTQKCKIPCNWKKQF 93
Cdd:pfam05196  12 SDCAEWQWGKCVPNSGDCGLGFREGT-----CKEQTKKIKCKIPCNWKKEF 57
 
Name Accession Description Interval E-value
PTN smart00193
Pleiotrophin / midkine family; Heparin-binding domain family.
 45-129 8.17e-44

Pleiotrophin / midkine family; Heparin-binding domain family.


Pssm-ID: 128490  Cd Length: 80  Bit Score: 139.63  E-value: 8.17e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679353681   45 CGEWQWSVCVPTNGDCGLGTREGTrtgaeCKQTTKTQKCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTGNLKRAL 124
Cdd:smart00193   1 CGEWQWGPCIPNSKDCGLGTREGT-----CGQETRKLKCKIPCNWKKQFGADCKYKFESWGECDANTGLKTRSGTLKKAL 75


                   ....*
gi 1679353681  125 HNADC 129
Cdd:smart00193  76 YNADC 80
PTN_MK_N pfam05196
PTN/MK heparin-binding protein family, N-terminal domain;
43-93 1.12e-23

PTN/MK heparin-binding protein family, N-terminal domain;


Pssm-ID: 461582  Cd Length: 57  Bit Score: 87.51  E-value: 1.12e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1679353681  43 SDCGEWQWSVCVPTNGDCGLGTREGTrtgaeCKQTTKTQKCKIPCNWKKQF 93
Cdd:pfam05196  12 SDCAEWQWGKCVPNSGDCGLGFREGT-----CKEQTKKIKCKIPCNWKKEF 57
PTN_MK_C pfam01091
PTN/MK heparin-binding protein family, C-terminal domain;
94-143 9.79e-22

PTN/MK heparin-binding protein family, C-terminal domain;


Pssm-ID: 460059  Cd Length: 65  Bit Score: 82.88  E-value: 9.79e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1679353681  94 GAECKYQFQAWGECDLNTALKTRTGNLKRALHNADCQKTVTISKPCGKLT 143
Cdd:pfam01091   1 GADCKYKFGAWGECDPATGTKTRTGTLKKALFNAECQQTVSVTKPCKPKT 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH