NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|123287|sp|P28357|]
View 

RecName: Full=Homeobox protein Hox-D9; AltName: Full=Homeobox protein Hox-4.4; AltName: Full=Homeobox protein Hox-5.2

Protein Classification

Hox9_act and homeodomain domain-containing protein( domain architecture ID 10928213)

Hox9_act and homeodomain domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Hox9_act super family cl04626
Hox9 activation region; This family constitutes the N termini of the paralogous homeobox ...
 1-153 2.47e-41

Hox9 activation region; This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9. The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex.


The actual alignment was detected with superfamily member pfam04617:

Pssm-ID: 461369  Cd Length: 182  Bit Score: 142.53  E-value: 2.47e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123287       1 MSSSGTLSNYYVDSLIGHEGDEVFAARFGP-PGPGTQGRPAGVADgpaaaTAEFASCSFAPKSSVFSASWSavAAQPPAA 79
Cdd:pfam04617   1 MSTSGTLSNYYVDSIISHESEDLYAPRFSSgPHVQQARQPSGVAD-----HADFPSCSFQPKSPVFSTSWS--PVHPQSS 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 123287      80 ATMSGLYHPYVSPPPLAAAEpGRYVRSWMEPLpgfpggagggggsgggggggPGPVPSPGGPANGRHYGIKPET 153
Cdd:pfam04617  74 AAVPSVYHPYVHQPHVPASD-GRYVRSWLEPI--------------------SGSVSFPGLPSTGRHYGIKPEP 126
Homeodomain pfam00046
Homeodomain;
273-324 1.40e-24

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 94.49  E-value: 1.40e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 123287     273 RKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARILNLTERQVKIWFQNRR 324
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRR 52
 
Name Accession Description Interval E-value
Hox9_act pfam04617
Hox9 activation region; This family constitutes the N termini of the paralogous homeobox ...
 1-153 2.47e-41

Hox9 activation region; This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9. The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex.


Pssm-ID: 461369  Cd Length: 182  Bit Score: 142.53  E-value: 2.47e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123287       1 MSSSGTLSNYYVDSLIGHEGDEVFAARFGP-PGPGTQGRPAGVADgpaaaTAEFASCSFAPKSSVFSASWSavAAQPPAA 79
Cdd:pfam04617   1 MSTSGTLSNYYVDSIISHESEDLYAPRFSSgPHVQQARQPSGVAD-----HADFPSCSFQPKSPVFSTSWS--PVHPQSS 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 123287      80 ATMSGLYHPYVSPPPLAAAEpGRYVRSWMEPLpgfpggagggggsgggggggPGPVPSPGGPANGRHYGIKPET 153
Cdd:pfam04617  74 AAVPSVYHPYVHQPHVPASD-GRYVRSWLEPI--------------------SGSVSFPGLPSTGRHYGIKPEP 126
Homeodomain pfam00046
Homeodomain;
273-324 1.40e-24

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 94.49  E-value: 1.40e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 123287     273 RKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARILNLTERQVKIWFQNRR 324
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRR 52
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 272-324 1.09e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 91.93  E-value: 1.09e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 123287      272 TRKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARILNLTERQVKIWFQNRR 324
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRR 53
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 273-324 8.37e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 89.61  E-value: 8.37e-23
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 123287   273 RKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARILNLTERQVKIWFQNRR 324
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRR 52
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
268-324 5.48e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 57.45  E-value: 5.48e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 123287   268 HARSTRKKRcpyTKYQTLELEKEFLFNMYLTRDRRYEVARILNLTERQVKIWFQNRR 324
Cdd:COG5576  50 PPKSKRRRT---TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKR 103
 
Name Accession Description Interval E-value
Hox9_act pfam04617
Hox9 activation region; This family constitutes the N termini of the paralogous homeobox ...
 1-153 2.47e-41

Hox9 activation region; This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9. The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex.


Pssm-ID: 461369  Cd Length: 182  Bit Score: 142.53  E-value: 2.47e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123287       1 MSSSGTLSNYYVDSLIGHEGDEVFAARFGP-PGPGTQGRPAGVADgpaaaTAEFASCSFAPKSSVFSASWSavAAQPPAA 79
Cdd:pfam04617   1 MSTSGTLSNYYVDSIISHESEDLYAPRFSSgPHVQQARQPSGVAD-----HADFPSCSFQPKSPVFSTSWS--PVHPQSS 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 123287      80 ATMSGLYHPYVSPPPLAAAEpGRYVRSWMEPLpgfpggagggggsgggggggPGPVPSPGGPANGRHYGIKPET 153
Cdd:pfam04617  74 AAVPSVYHPYVHQPHVPASD-GRYVRSWLEPI--------------------SGSVSFPGLPSTGRHYGIKPEP 126
Homeodomain pfam00046
Homeodomain;
273-324 1.40e-24

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 94.49  E-value: 1.40e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 123287     273 RKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARILNLTERQVKIWFQNRR 324
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRR 52
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 272-324 1.09e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 91.93  E-value: 1.09e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 123287      272 TRKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARILNLTERQVKIWFQNRR 324
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRR 53
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 273-324 8.37e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 89.61  E-value: 8.37e-23
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 123287   273 RKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARILNLTERQVKIWFQNRR 324
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRR 52
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
268-324 5.48e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 57.45  E-value: 5.48e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 123287   268 HARSTRKKRcpyTKYQTLELEKEFLFNMYLTRDRRYEVARILNLTERQVKIWFQNRR 324
Cdd:COG5576  50 PPKSKRRRT---TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKR 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH