Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.

                           10        20
                   ....*....|....*....|.
gi 1345709     167 NPDYEPIRKGQRDLYSGLNQR 187
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21

Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 epsilon chain; member of the C1-set of IgSF domains; The members here are composed of the immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 epsilon chain. CD3 is a T cell surface receptor that is associated with alpha/beta T cell receptors (TCRs). The CD3 complex consists of one gamma, one delta, two epsilon, and two zeta chains. The CD3 subunits form heterodimers as gamma/epsilon, delta/epsilon, and zeta/zeta. The gamma, delta, and epsilon chains each contain an extracellular Ig domain, whereas the extracellular domains of the zeta chains are very small and have unknown structure. The CD3 domain participates in intracellular signaling once the TCR has bound an MHC/antigen complex.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1345709   29 YKVSISGTSVELTCPLDSDENLKWEKNGQELPQKHD--KHLVLQDFSEVEDSGYYVCYTPASN--KNTYLYLKAR 99
Cdd:cd07692   1 YKVSISGTSVELTCPKDFENGIQWKRNDNNEQMKGHneKYLSLKEFSEMESSGYYQCYATEGNteAAHYLYLRAR 75

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345709      35 GTSVELTCPLDSDEN--LKWEKNGQELPQKHDKHLVLQDFS---------EVEDSGYYVC 83
Cdd:smart00410   9 GESVTLSCEASGSPPpeVTWYKQGGKLLAESGRFSVSRSGStstltisnvTPEDSGTYTC 68

Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 epsilon chain; member of the C1-set of IgSF domains; The members here are composed of the immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 epsilon chain. CD3 is a T cell surface receptor that is associated with alpha/beta T cell receptors (TCRs). The CD3 complex consists of one gamma, one delta, two epsilon, and two zeta chains. The CD3 subunits form heterodimers as gamma/epsilon, delta/epsilon, and zeta/zeta. The gamma, delta, and epsilon chains each contain an extracellular Ig domain, whereas the extracellular domains of the zeta chains are very small and have unknown structure. The CD3 domain participates in intracellular signaling once the TCR has bound an MHC/antigen complex.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1345709   29 YKVSISGTSVELTCPLDSDENLKWEKNGQELPQKHD--KHLVLQDFSEVEDSGYYVCYTPASN--KNTYLYLKAR 99
Cdd:cd07692   1 YKVSISGTSVELTCPKDFENGIQWKRNDNNEQMKGHneKYLSLKEFSEMESSGYYQCYATEGNteAAHYLYLRAR 75

Fifth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fifth immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345709   33 ISGTSVELTC-----PLDSdenLKWEKNGQELPQKHDKH------LVLQDFSEVEDSGYYVCYtpASNKN 91
Cdd:cd20958  13 VAGQTLRLHCpvagyPISS---ITWEKDGRRLPLNHRQRvfpngtLVIENVQRSSDEGEYTCT--ARNQQ 77

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.

                           10        20
                   ....*....|....*....|.
gi 1345709     167 NPDYEPIRKGQRDLYSGLNQR 187
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345709      35 GTSVELTCPLDSDEN--LKWEKNGQELPQKHDKHLVLQDFS---------EVEDSGYYVC 83
Cdd:smart00410   9 GESVTLSCEASGSPPpeVTWYKQGGKLLAESGRFSVSRSGStstltisnvTPEDSGTYTC 68

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1345709   38 VELTCPLDSDE--NLKWEKNGQELPQK---------HDKHLVLQDFSEvEDSGYYVCYtpASNK 90
Cdd:cd00096   1 VTLTCSASGNPppTITWYKNGKPLPPSsrdsrrselGNGTLTISNVTL-EDSGTYTCV--ASNS 61