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Conserved domains on  [gi|1698165636|sp|P0DN84|]
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RecName: Full=Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF; Short=SERCA regulator DWORF; AltName: Full=Dwarf open reading frame; Short=DWORF; AltName: Full=Small transmembrane regulator of ion transport 1

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DWORF cd20247
DWarf Open Reading Frame (DWORF); DWarf Open Reading Frame (DWORF) is a small protein that ...
 1-35 4.07e-13

DWarf Open Reading Frame (DWORF); DWarf Open Reading Frame (DWORF) is a small protein that plays a key role in heart muscle contraction. DWORF, Sarcolipin (SLN), and myoregulin (MRLN) are transmembrane regulators of the sarcoplasmic reticulum calcium transporting ATPase (SERCA). DWORF enhances SERCA activity by displacing phospholamban (PLN), a potent SERCA inhibitor. This makes DWORF an attractive candidate for a heart failure therapeutic. DWORF is also present in slow-twitch skeletal muscle fibers.


:

Pssm-ID: 380779  Cd Length: 35  Bit Score: 55.03  E-value: 4.07e-13
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 1698165636  1 MAEKAGSTFSHLLVPILLLIGWIVGCIIMIYVVFS 35
Cdd:cd20247    1 MAEKAESTLSRLLVPILLLIGWIVGCIIMVYVVFS 35
 
Name Accession Description Interval E-value
DWORF cd20247
DWarf Open Reading Frame (DWORF); DWarf Open Reading Frame (DWORF) is a small protein that ...
 1-35 4.07e-13

DWarf Open Reading Frame (DWORF); DWarf Open Reading Frame (DWORF) is a small protein that plays a key role in heart muscle contraction. DWORF, Sarcolipin (SLN), and myoregulin (MRLN) are transmembrane regulators of the sarcoplasmic reticulum calcium transporting ATPase (SERCA). DWORF enhances SERCA activity by displacing phospholamban (PLN), a potent SERCA inhibitor. This makes DWORF an attractive candidate for a heart failure therapeutic. DWORF is also present in slow-twitch skeletal muscle fibers.


Pssm-ID: 380779  Cd Length: 35  Bit Score: 55.03  E-value: 4.07e-13
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 1698165636  1 MAEKAGSTFSHLLVPILLLIGWIVGCIIMIYVVFS 35
Cdd:cd20247    1 MAEKAESTLSRLLVPILLLIGWIVGCIIMVYVVFS 35
 
Name Accession Description Interval E-value
DWORF cd20247
DWarf Open Reading Frame (DWORF); DWarf Open Reading Frame (DWORF) is a small protein that ...
 1-35 4.07e-13

DWarf Open Reading Frame (DWORF); DWarf Open Reading Frame (DWORF) is a small protein that plays a key role in heart muscle contraction. DWORF, Sarcolipin (SLN), and myoregulin (MRLN) are transmembrane regulators of the sarcoplasmic reticulum calcium transporting ATPase (SERCA). DWORF enhances SERCA activity by displacing phospholamban (PLN), a potent SERCA inhibitor. This makes DWORF an attractive candidate for a heart failure therapeutic. DWORF is also present in slow-twitch skeletal muscle fibers.


Pssm-ID: 380779  Cd Length: 35  Bit Score: 55.03  E-value: 4.07e-13
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 1698165636  1 MAEKAGSTFSHLLVPILLLIGWIVGCIIMIYVVFS 35
Cdd:cd20247    1 MAEKAESTLSRLLVPILLLIGWIVGCIIMVYVVFS 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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