NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1064303022|sp|P0CU17|]
View 

RecName: Full=26S proteasome regulatory subunit rpn501

Protein Classification

26S proteasome non-ATPase regulatory subunit 12( domain architecture ID 10009068)

26S proteasome non-ATPase regulatory subunit 12 (PSMD12), also known as RPN7, is a non-ATPase subunit of the 19S regulatory complex of the 26S proteasome which is involved in the recognition of ubiquitinated protein substrates, and it plays a role in the degradation of these substrates by the proteasome

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
RPN5 COG5071
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
1-438 0e+00

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 227403 [Multi-domain]  Cd Length: 439  Bit Score: 689.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1064303022   1 MEQKPEVDYSEKFAELQKSLNNLNTIDIDANLEKLLIFEKQVRQASDTSTNTKVLIYIADLLFRAGDFQGLNEQLVSLFK 80
Cdd:COG5071     1 MEQKPEVDYSEKFAELQKSLNNLNTIDIDANLEKLLIFEKKVRQASDTSTNTKVLIYIADLLFSAGDFQGLNEQLVSLFK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1064303022  81 KHGQLKQSMTSLVQHVMTYLPGIDDLKTKINLIETLRTITDGKIYVEVERARLTQLLSQIKEEQGDIKSAQEILCNEPVE 160
Cdd:COG5071    81 KHGQLKQSITSMIQHVMEYLKGIDDLKTKINLIETLRTVTEGKIFVEVERARLTQLLSQIKEEQGDIKSAQDILCNEPVE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1064303022 161 TYGSFDLKEKVAFILDQVRLFLLRSDYYMASTYTKKINVKFFEKEDVQSLKLKYYEQKIRIGLHDDAYLDVCKYYRAVYD 240
Cdd:COG5071   161 TYGSFDLSEKVAFILEQVRLFLLRSDYYMASTYTKKINKKFFEKEDVQSLKLKYYELKVRIGLHDRAYLDVCKYYRAVYD 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1064303022 241 TAVVQEDPEKWKEILENVVCFALLTPYDNEQADLLHRINADHKLNSLPLLQQLVKCFIVNELMRWPKIAEIYGSALRSNp 320
Cdd:COG5071   241 TAVVQEDPAKWKEVLSNVVCFALLTPYDNEQADLLHKINADHKLNSLPLLQQLVKCFIVNELMRWPKVAEIYGSALRSN- 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1064303022 321 VFAENDEKGEKRWSELRKRVIEHNIRVVANYYSRIHCSRLGVLLDMSPSETEQFLCDLIAKHHFYAKIDRPAQVISFKKS 400
Cdd:COG5071   320 VFAFNDEKGEKRWSDLRKRVIEHNIRVIANYYSRIHCSRLGVLLDMSPSETEQFISDLVNKGHFYAKINRPAQIISFEKS 399
                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1064303022 401 QNVQEQLNEWGSNITELLGKLEKVRQLIIKEEMMNSIQ 438
Cdd:COG5071   400 QNVQEQLNEWGSNVTELLGKLEKVRHLIIKEEMMNSIQ 437
 
Name Accession Description Interval E-value
RPN5 COG5071
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
1-438 0e+00

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227403 [Multi-domain]  Cd Length: 439  Bit Score: 689.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1064303022   1 MEQKPEVDYSEKFAELQKSLNNLNTIDIDANLEKLLIFEKQVRQASDTSTNTKVLIYIADLLFRAGDFQGLNEQLVSLFK 80
Cdd:COG5071     1 MEQKPEVDYSEKFAELQKSLNNLNTIDIDANLEKLLIFEKKVRQASDTSTNTKVLIYIADLLFSAGDFQGLNEQLVSLFK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1064303022  81 KHGQLKQSMTSLVQHVMTYLPGIDDLKTKINLIETLRTITDGKIYVEVERARLTQLLSQIKEEQGDIKSAQEILCNEPVE 160
Cdd:COG5071    81 KHGQLKQSITSMIQHVMEYLKGIDDLKTKINLIETLRTVTEGKIFVEVERARLTQLLSQIKEEQGDIKSAQDILCNEPVE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1064303022 161 TYGSFDLKEKVAFILDQVRLFLLRSDYYMASTYTKKINVKFFEKEDVQSLKLKYYEQKIRIGLHDDAYLDVCKYYRAVYD 240
Cdd:COG5071   161 TYGSFDLSEKVAFILEQVRLFLLRSDYYMASTYTKKINKKFFEKEDVQSLKLKYYELKVRIGLHDRAYLDVCKYYRAVYD 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1064303022 241 TAVVQEDPEKWKEILENVVCFALLTPYDNEQADLLHRINADHKLNSLPLLQQLVKCFIVNELMRWPKIAEIYGSALRSNp 320
Cdd:COG5071   241 TAVVQEDPAKWKEVLSNVVCFALLTPYDNEQADLLHKINADHKLNSLPLLQQLVKCFIVNELMRWPKVAEIYGSALRSN- 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1064303022 321 VFAENDEKGEKRWSELRKRVIEHNIRVVANYYSRIHCSRLGVLLDMSPSETEQFLCDLIAKHHFYAKIDRPAQVISFKKS 400
Cdd:COG5071   320 VFAFNDEKGEKRWSDLRKRVIEHNIRVIANYYSRIHCSRLGVLLDMSPSETEQFISDLVNKGHFYAKINRPAQIISFEKS 399
                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1064303022 401 QNVQEQLNEWGSNITELLGKLEKVRQLIIKEEMMNSIQ 438
Cdd:COG5071   400 QNVQEQLNEWGSNVTELLGKLEKVRHLIIKEEMMNSIQ 437
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
288-399 2.33e-19

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 83.04  E-value: 2.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1064303022 288 PLLQQLVKCFIVNELMRWPKIAEIYGSALRSNPVFAEndekgekRWSELRKRVIEHNIRVVANYYSRIHCSRLGVLLDMS 367
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAE-------HLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLS 73
                          90       100       110
                  ....*....|....*....|....*....|..
gi 1064303022 368 PSETEQFLCDLIAKHHFYAKIDRPAQVISFKK 399
Cdd:pfam01399  74 VDEVEKILAKLIRDGRIRAKIDQVNGIVVFSK 105
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
331-417 5.89e-11

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 58.41  E-value: 5.89e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1064303022  331 KRWSELRKRVIEHNIRVVANYYSRIHCSRLGVLLDMSPSETEQFLCDLIAKHHFYAKIDRPAQVISFKKSQN-VQEQLNE 409
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPrRSEPLAQ 80

                   ....*...
gi 1064303022  410 WGSNITEL 417
Cdd:smart00088  81 FAETLKKL 88
 
Name Accession Description Interval E-value
RPN5 COG5071
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
1-438 0e+00

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227403 [Multi-domain]  Cd Length: 439  Bit Score: 689.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1064303022   1 MEQKPEVDYSEKFAELQKSLNNLNTIDIDANLEKLLIFEKQVRQASDTSTNTKVLIYIADLLFRAGDFQGLNEQLVSLFK 80
Cdd:COG5071     1 MEQKPEVDYSEKFAELQKSLNNLNTIDIDANLEKLLIFEKKVRQASDTSTNTKVLIYIADLLFSAGDFQGLNEQLVSLFK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1064303022  81 KHGQLKQSMTSLVQHVMTYLPGIDDLKTKINLIETLRTITDGKIYVEVERARLTQLLSQIKEEQGDIKSAQEILCNEPVE 160
Cdd:COG5071    81 KHGQLKQSITSMIQHVMEYLKGIDDLKTKINLIETLRTVTEGKIFVEVERARLTQLLSQIKEEQGDIKSAQDILCNEPVE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1064303022 161 TYGSFDLKEKVAFILDQVRLFLLRSDYYMASTYTKKINVKFFEKEDVQSLKLKYYEQKIRIGLHDDAYLDVCKYYRAVYD 240
Cdd:COG5071   161 TYGSFDLSEKVAFILEQVRLFLLRSDYYMASTYTKKINKKFFEKEDVQSLKLKYYELKVRIGLHDRAYLDVCKYYRAVYD 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1064303022 241 TAVVQEDPEKWKEILENVVCFALLTPYDNEQADLLHRINADHKLNSLPLLQQLVKCFIVNELMRWPKIAEIYGSALRSNp 320
Cdd:COG5071   241 TAVVQEDPAKWKEVLSNVVCFALLTPYDNEQADLLHKINADHKLNSLPLLQQLVKCFIVNELMRWPKVAEIYGSALRSN- 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1064303022 321 VFAENDEKGEKRWSELRKRVIEHNIRVVANYYSRIHCSRLGVLLDMSPSETEQFLCDLIAKHHFYAKIDRPAQVISFKKS 400
Cdd:COG5071   320 VFAFNDEKGEKRWSDLRKRVIEHNIRVIANYYSRIHCSRLGVLLDMSPSETEQFISDLVNKGHFYAKINRPAQIISFEKS 399
                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1064303022 401 QNVQEQLNEWGSNITELLGKLEKVRQLIIKEEMMNSIQ 438
Cdd:COG5071   400 QNVQEQLNEWGSNVTELLGKLEKVRHLIIKEEMMNSIQ 437
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
288-399 2.33e-19

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 83.04  E-value: 2.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1064303022 288 PLLQQLVKCFIVNELMRWPKIAEIYGSALRSNPVFAEndekgekRWSELRKRVIEHNIRVVANYYSRIHCSRLGVLLDMS 367
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAE-------HLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLS 73
                          90       100       110
                  ....*....|....*....|....*....|..
gi 1064303022 368 PSETEQFLCDLIAKHHFYAKIDRPAQVISFKK 399
Cdd:pfam01399  74 VDEVEKILAKLIRDGRIRAKIDQVNGIVVFSK 105
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
331-417 5.89e-11

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 58.41  E-value: 5.89e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1064303022  331 KRWSELRKRVIEHNIRVVANYYSRIHCSRLGVLLDMSPSETEQFLCDLIAKHHFYAKIDRPAQVISFKKSQN-VQEQLNE 409
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPrRSEPLAQ 80

                   ....*...
gi 1064303022  410 WGSNITEL 417
Cdd:smart00088  81 FAETLKKL 88
RPN5_C pfam18098
26S proteasome regulatory subunit RPN5 C-terminal domain; This is the C-terminal domain of the ...
405-435 2.20e-07

26S proteasome regulatory subunit RPN5 C-terminal domain; This is the C-terminal domain of the 26S proteasome regulatory subunit RPN5 proteins.This helical domain can be found adjacent to pfam01399. The 26S proteasome is the major ATP-dependent protease in eukaryotes. Three subcomplexes form this degradation machine: the lid, the base, and the core. The helices found at the C terminus of each lid subunit form a helical bundle that directs the ordered self-assembly of the lid subcomplex. This domain which comprises the tail of RPN5 along with the tail of Rpn9, are important for Rpn12 binding to the lid.


Pssm-ID: 436272  Cd Length: 32  Bit Score: 46.83  E-value: 2.20e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1064303022 405 EQLNEWGSNITELLGKLEKVRQLIIKEEMMN 435
Cdd:pfam18098   2 EVLNEWSHNVNSLLELVEKTTHLINKEEMVH 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH