RecName: Full=Protein ELFN1; AltName: Full=Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1; AltName: Full=Protein phosphatase 1 regulatory subunit 28; Flags: Precursor
leucine-rich repeat domain-containing protein( domain architecture ID 11471162)
leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
LRR_8 | pfam13855 | Leucine rich repeat; |
85-144 | 2.46e-14 | ||||
Leucine rich repeat; : Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 67.93 E-value: 2.46e-14
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
17-190 | 9.52e-14 | ||||
Leucine-rich repeat (LRR) protein [Transcription]; : Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 74.20 E-value: 9.52e-14
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PCC super family | cl28216 | polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
162-256 | 6.31e-07 | ||||
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half. The actual alignment was detected with superfamily member TIGR00864: Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 53.55 E-value: 6.31e-07
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Name | Accession | Description | Interval | E-value | ||||
LRR_8 | pfam13855 | Leucine rich repeat; |
85-144 | 2.46e-14 | ||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 67.93 E-value: 2.46e-14
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
17-190 | 9.52e-14 | ||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 74.20 E-value: 9.52e-14
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PCC | TIGR00864 | polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
162-256 | 6.31e-07 | ||||
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half. Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 53.55 E-value: 6.31e-07
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LRRCT | smart00082 | Leucine rich repeat C-terminal domain; |
190-228 | 9.73e-07 | ||||
Leucine rich repeat C-terminal domain; Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 46.27 E-value: 9.73e-07
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
65-147 | 1.47e-06 | ||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 49.78 E-value: 1.47e-06
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
86-190 | 4.50e-03 | ||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 40.60 E-value: 4.50e-03
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Name | Accession | Description | Interval | E-value | ||||
LRR_8 | pfam13855 | Leucine rich repeat; |
85-144 | 2.46e-14 | ||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 67.93 E-value: 2.46e-14
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
17-190 | 9.52e-14 | ||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 74.20 E-value: 9.52e-14
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
65-210 | 1.89e-13 | ||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 73.04 E-value: 1.89e-13
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
65-202 | 4.39e-12 | ||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 68.81 E-value: 4.39e-12
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LRR_8 | pfam13855 | Leucine rich repeat; |
109-168 | 3.85e-09 | ||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 53.30 E-value: 3.85e-09
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LRR_8 | pfam13855 | Leucine rich repeat; |
65-120 | 5.64e-08 | ||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 50.22 E-value: 5.64e-08
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PCC | TIGR00864 | polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
162-256 | 6.31e-07 | ||||
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half. Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 53.55 E-value: 6.31e-07
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LRRCT | smart00082 | Leucine rich repeat C-terminal domain; |
190-228 | 9.73e-07 | ||||
Leucine rich repeat C-terminal domain; Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 46.27 E-value: 9.73e-07
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
65-147 | 1.47e-06 | ||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 49.78 E-value: 1.47e-06
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RNA1 | COG5238 | Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
34-168 | 7.81e-04 | ||||
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis]; Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 42.85 E-value: 7.81e-04
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LRR_5 | pfam13306 | BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ... |
85-195 | 3.36e-03 | ||||
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis. Pssm-ID: 463839 [Multi-domain] Cd Length: 127 Bit Score: 38.29 E-value: 3.36e-03
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
86-190 | 4.50e-03 | ||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 40.60 E-value: 4.50e-03
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Blast search parameters | ||||
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