|
Name |
Accession |
Description |
Interval |
E-value |
| PQQ_membr_DH |
TIGR03074 |
membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; This protein ... |
31-798 |
0e+00 |
|
membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Members of this family have several predicted transmembrane helices in the N-terminal region, and include the quinoprotein glucose dehydrogenase (EC 1.1.5.2) of Escherichia coli and the quinate/shikimate dehydrogenase of Acinetobacter sp. ADP1 (EC 1.1.99.25). Sequences closely related except for the absense of the N-terminal hydrophobic region, scoring in the gray zone between the trusted and noise cutoffs, include PQQ-dependent glycerol (EC 1.1.99.22) and and other polyol (sugar alcohol) dehydrogenases.
Pssm-ID: 274418 [Multi-domain] Cd Length: 764 Bit Score: 1215.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 31 WLATLGGSIYYIIAGVLLLIVAWQLYKRASTALWFYAALMLGTIIWSVWEVGTDFWALAPRLDILGILGLWLLVPAVTR- 109
Cdd:TIGR03074 1 WLVALGGSWYYLLAGLALLLSAWLLFRRRPAGLWLYAALLLGTLIWALWEVGLDFWPLIPRLGLIAVLGLWLLLPWVRRp 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 110 -GINNLGSSKVALSSTLAIAIVLMVYSIFNDPQEINGEIKTPQPETAQAVPGVAESDWPAYGRTQAGVRYSPLKQINDQN 188
Cdd:TIGR03074 81 rSVGPARRGAGALAGVLAVAVLAALASMFTDPHPIVGALDTEVPATAAAAPAVPAGDWAAYGRTQAGQRYSPLDQINPDN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 189 VKDLKVAWTLRTGDLKTDNDSGETTNQVTPIKIGNNMFICTAHQQLIAIDPATGKEKWRFDPKLKTDKSFQHLTCRGVMY 268
Cdd:TIGR03074 161 VGNLKVAWTYHTGDLKTPDDPGEATFQATPLKVGDTLYLCTPHNKVIALDAATGKEKWKFDPKLKTEADRQHQTCRGVSY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 269 YDANNTTEFATslqsKKSSSTQCPRKVFVPVNDGRLVAVNADTGKACTDFGQNGQVNLQEFMPYAYPGGYNPTSPGIVTG 348
Cdd:TIGR03074 241 YDAPAAAAGPA----GPAAPADCARRIILPTSDARLIALDADTGKLCEDFGNNGTVDLTAGMGPTPPGYYYPTSPPLVAG 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 349 STVVIAGSVTDNYSNKEPSGVIRGYDVNTGKLLWVFDTGAADPNAMPGEGTTFVHNSPNAWAPLAYDAKLDIVYVPTGVG 428
Cdd:TIGR03074 317 TTVVIGGRVADNYSTDEPSGVIRAFDVNTGALVWAWDPGNPDPTAPPAPGETYTRNSPNSWSVASYDEKLGLVYLPMGNQ 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 429 TPDIWGGDRTELKERYANSMLAINASTGKLVWNFQTTHHDLWDMDVPSQPSLADIKNKAGQTVPAIYVLTKTGNAFVLDR 508
Cdd:TIGR03074 397 TPDQWGGDRTPADEKYSSSLVALDATTGKERWVFQTVHHDLWDMDVPAQPSLVDLPKADGTTVPALVAPTKQGQIYVLDR 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 509 RNGQPIVPVTEKPVPQtvkrgPQTKGEFYSKTQPFSDLNLAPQDkLTDKDMWGATMLDQLMCRVSFKRLNYDGIYTPPSE 588
Cdd:TIGR03074 477 RTGEPIVPVEEVPVPQ-----GAVPGERYSPTQPFSVLTFGPPT-LTESDMWGATPFDQLACRIQFKSLRYEGLYTPPSE 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 589 NGTLVFPGNLGVFEWGGMSVNPDRQVAVMNPIGLPFVSRLIPADP--NRAQTAKGAGTEQGVQPMYGVPYGVEISAFLSP 666
Cdd:TIGR03074 551 QGSLVFPGNLGGFNWGGVAVDPTRQVMFVNPMRLPFVSQLVPRAPgdEAPSGAKGKGTEMGLNPNKGTPYAVNMNPFLSP 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 667 LGLPCKQPAWGYVAGVDLKTHEVVWKKRIGTIRDSLPNLFQLP-AVKIGVPGLGGSISTAGNVMFVGATQDNYLRAFNVT 745
Cdd:TIGR03074 631 LGIPCQAPPWGYMAAIDLKTGKVVWQHPNGTVRDTGPMGIPMPlPIPIGVPTLGGPLATAGGLVFIGATQDNYLRAYDLS 710
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....
gi 118558 746 NGKKLWEARLPAGGQATPMTY-EINGKQYVVIMAGGHGSFGTKMGDYLVAYALP 798
Cdd:TIGR03074 711 TGKELWEARLPAGGQATPMTYmGKDGKQYVVIVAGGHGSSGTKRGDYVIAYALP 764
|
|
| PQQ_mGDH |
cd10280 |
Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes ... |
166-797 |
0e+00 |
|
Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes belongs to the dehydrogenase family with pyrroloquinoline quinone (PQQ) as cofactor, and is the only subfamily that is bound to the membrane. Glucose dehydrogenase converts D-glucose to D-glucono-1,5-lactone in a reaction that is coupled with the respiratory chain in the periplasmic oxidation of sugars and alcohols in gram-negative bacteria. Ubiquinone functions as the electron acceptor. The alignment model contains an 8-bladed beta-propeller.
Pssm-ID: 199838 [Multi-domain] Cd Length: 616 Bit Score: 883.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 166 WPAYGRTQAGVRYSPLKQINDQNVKDLKVAWTLRTGDLKTDnDSGETTNQVTPIKIGNNMFICTAHQQLIAIDPATGKEK 245
Cdd:cd10280 1 WPAYGGDPGGTRYSPLDQITPDNVGKLKVAWTYHTGDLPGP-DGNEGTFEATPLKVGGTLYLCTPHNRVIALDAATGKEL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 246 WRFDPKLKTDKSFQHLTCRGVMYYDAnnttefatslqskKSSSTQCPRKVFVPVNDGRLVAVNADTGKACTDFGQNGQVN 325
Cdd:cd10280 80 WRFDPKAGADAAPGHQTCRGVSYWED-------------GAAAAACARRIFFGTGDARLIALDARTGKPCPDFGDNGVVD 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 326 LQEFMPYAYPGGYNPTSPGIVTGSTVVIAGSVTDNYSNKEPSGVIRGYDVNTGKLLWVFDTGAADPNAMPG-EGTTFVHN 404
Cdd:cd10280 147 LREGLGRVKPGFYSSTSPPTVYGDLVIVGSAVADNQAVDAPSGVIRAFDVRTGKLVWAFDTIPPPGEAGPDtAGAWYTRG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 405 SPNAWAPLAYDAKLDIVYVPTGVGTPDIWGGDRTElKERYANSMLAINASTGKLVWNFQTTHHDLWDMDVPSQPSLADIK 484
Cdd:cd10280 227 GPNVWAGMSADEKLGLVYLPTGSATPDFYGGDRPG-DNLFANSLVALDAATGKRRWHFQTVHHDLWDYDLPAQPTLVDVP 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 485 nKAGQTVPAIYVLTKTGNAFVLDRRNGQPIVPVTEKPVPQ-TVKrgpqtkGEFYSKTQPFSDL--NLAPQDkLTDKDMWG 561
Cdd:cd10280 306 -RDGKTVPAVAQPTKQGFVFVLDRRTGKPLWPVEERPVPQgDVP------GERTSPTQPFPTLppPFARQG-LTEDDMWG 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 562 ATMLDQLMCRVSFKRLNYDGIYTPPSENGTLVFPGNLGVFEWGGMSVNPDRQVAVMNPIGLPFVSRLIPADP----NRAQ 637
Cdd:cd10280 378 ATPFDQLACRIQFRSLRYEGLFTPPSLDGTLIFPGNDGGANWGGAAVDPERGILYVNSNRLPFVIQLVPRAPgdpaGVAG 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 638 TAKGAGTEQGVQPMYGVPYGVEISAFLSPLGLPCKQPAWGYVAGVDLKTHEVVWKKRIGTIRDSLPNLFQLPaVKIGVPG 717
Cdd:cd10280 458 GGEGGGGGGGPSPQAGTPYGVGRGRFLSPLGLPCQAPPWGTLTAIDLNTGKILWQVPLGTVPDLGPKGIPLP-IPTGTPN 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 718 LGGSISTAGNVMFVGATQDNYLRAFNVTNGKKLWEARLPAGGQATPMTYEINGKQYVVIMAGGHGSFGTKMGDYLVAYAL 797
Cdd:cd10280 537 LGGPVVTAGGLVFIAATQDNYLRAFDKATGKELWEARLPAGGQATPMTYEVDGKQYVVIAAGGHGSLGTKRGDSVIAYAL 616
|
|
| Gcd |
COG4993 |
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism]; |
162-798 |
0e+00 |
|
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];
Pssm-ID: 444017 [Multi-domain] Cd Length: 515 Bit Score: 645.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 162 AESDWPAYGRTQAGVRYSPLKQINDQNVKDLKVAWTLRTGDLKtdndsgETTNQVTPIKIGNNMFICTAHQQLIAIDPAT 241
Cdd:COG4993 1 DPGDWLAYGGDYAGQRYSPLDQINPDNVKKLKVAWTFSTGDLP------ERGHEATPLVVDGVLYVCTPHNRVFALDAAT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 242 GKEKWRFDPKLKTDKSFQHLTCRGVMYYDannttefatslqskkssstqcpRKVFVPVNDGRLVAVNADTGKACTDfGQN 321
Cdd:COG4993 75 GKELWRYDPKLPDDAACCDVVNRGVAYYD----------------------GRIFLGTLDGRLVALDAKTGKVCWD-VKV 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 322 GQvnlqefmpyaYPGGYNPTSPGIVTGSTVVIAGSVTDNysnkEPSGVIRGYDVNTGKLLWVFDTGAaDPNAM----PGE 397
Cdd:COG4993 132 GD----------PKKGYTITSAPLVVKDKVIVGGSGGEF----GPRGVVRAYDARTGKLVWRFDTIP-DPGEPgaetWPP 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 398 GTTFVHNSPNAWAPLAYDAKLDIVYVPTGVGTPDIWGGDRtELKERYANSMLAINASTGKLVWNFQTTHHDLWDMDVPSQ 477
Cdd:COG4993 197 GDTWKRGGGNVWGTMSYDPELGLVYLPTGNPAPDWNGGQR-PGDNLYSSSIVALDADTGELKWHYQTVPHDLWDYDGPNE 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 478 PSLADIKnKAGQTVPAIYVLTKTGNAFVLDRRNGQPIVpvtekpvpqtvkrgpqtkgefyskTQPFSD-LNLApqdklTD 556
Cdd:COG4993 276 PILVDLP-VDGKTRKALVQATKNGFIYVLDRETGEPLV------------------------TQPFVKpPNWA-----TE 325
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 557 KDMWGATMldqlmcrvsfkrlnydgIYTPPSENG--TLVFPGNLGVFEWGGMSVNPDRQVAVMNPIGLPFVSRLIPadpn 634
Cdd:COG4993 326 IDMWGATP-----------------IQTPPSLDGktTLICPGALGGKNWGPAAYDPETGLLYVPANELCMDYELVP---- 384
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 635 raqtakgagteqgVQPMYGVPY-GVEISAFlsplglPCKQPAWGYVAGVDLKTHEVVWKkrigtirdslpnlfqlpaVKI 713
Cdd:COG4993 385 -------------REYQAGAPYlGATLTMY------PCPAPPWGTLTAIDLNTGKIVWQ------------------VPL 427
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 714 GVPGLGGSISTAGNVMFVGaTQDNYLRAFNVTNGKKLWEARLPAGGQATPMTYEINGKQYVVIMAGGHGSFG----TKMG 789
Cdd:COG4993 428 GFPNWGGPLATAGGLVFIG-TLDGYLRAFDAKTGKELWKFRLPSGGQATPMTYEVDGKQYVAVAAGGGGWLGlglyTPQG 506
|
....*....
gi 118558 790 DYLVAYALP 798
Cdd:COG4993 507 DYLIAFALP 515
|
|
| PQQ_DH_like |
cd00216 |
PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases ... |
186-796 |
3.76e-112 |
|
PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases with pyrroloquinoline quinone (PQQ) as a cofactor, such as ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller, and the family also includes distantly related proteins which are not enzymatically active and do not bind PQQ.
Pssm-ID: 199833 [Multi-domain] Cd Length: 434 Bit Score: 348.44 E-value: 3.76e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 186 DQNVKDLKVAWTLRTGDlktdndSGETTNQVTPIKIGNNMFICTAHQQLIAIDPATGKEKWRFDPKLKTD--KSFQHLTC 263
Cdd:cd00216 1 ADNVFQLTPAWSFSTGD------GGNRGSELTPIVVDGVMYATTSFSRVFALDADDGKEIWSYDPALKDGwfEACCDLVN 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 264 RGVMYYdannttefatslqskkssstqcPRKVFVPVNDGRLVAVNADTGKACTDFGQNGqvnlqefmpyaYPGGYNPTSP 343
Cdd:cd00216 75 RGVAVW----------------------GGKVYIGVLDGRVYALNAETGKVAWKVKNAD-----------VLGGYTATSA 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 344 GIVTgSTVVIAGSVTDNYsnkEPSGVIRGYDVNTGKLLWVFDTGAADPNAMP-------------GEGTTFVHNSPNAWA 410
Cdd:cd00216 122 PVVV-DGLVIIGSSGDEF---GVRGYLTAYDVATGEEKWRFYLVMPDPNLLPgkdstvtdrntptGDEHTWTSGGGTGWS 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 411 PLAYDAKLDIVYVPTGVGTPDIWGGDRTELKERYANSMLAINASTGKLVWNFQTTHHDLWDMDVPSQPSLADIKNKaGQT 490
Cdd:cd00216 198 SAAYDAELNLIYVGGGNPTPWNWGGNRTPGDNLYTSSIVAVNADTGEMKWQYQTTPHDAWDYDGDNTPVLADIKVK-GKK 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 491 VPAIYVLTKTGNAFVLDRRNGQPIVPvtekpvpqtvkrgpqtkgefysktqpfsdlnlapqdkltdkdmwgatmldqlmc 570
Cdd:cd00216 277 VKVLFAPAKNGNFYVLDRRNGELVSA------------------------------------------------------ 302
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 571 rvsfkrlnydgiytppsengtlvfpgnlgvFEWGGMSVNPDRQVAVMnpiglpfvsrlipadpnraqtakgagteqgvqp 650
Cdd:cd00216 303 ------------------------------RPLVPDSYDPDRELFYV--------------------------------- 319
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 651 mygvpygveisaflsplglpckqPAWGYVAGVDLKTHEVVWKKRIGTirdslpnlfqlpavkigvPGLGGSISTAGNVMF 730
Cdd:cd00216 320 -----------------------PANGRIMALDPVTGVVVWEKSELH------------------PLLGGPLSTAGNLVF 358
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 118558 731 VGATqDNYLRAFNVTNGKKLWEARLPAGGQATPMTYEINGKQYVVIMAGGHGSF-----------GTKMGDYLVAYA 796
Cdd:cd00216 359 VGTS-DGYLKAYNADTGEKLWQQKVPSGFQAEPVTYEVDGEQYVLIQAGGGGAFplwggmadltrGTQMGGTVVVYK 434
|
|
| PQQ_ADH_I |
cd10277 |
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ... |
165-779 |
1.15e-74 |
|
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.
Pssm-ID: 199835 [Multi-domain] Cd Length: 529 Bit Score: 252.22 E-value: 1.15e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 165 DWPAYGRTQAGVRYSPLKQINDQNVKDLKVAWTLRTGDLKTDNDSgettnqvTPIKIGNNMFICTAHQQLIAIDPATGKE 244
Cdd:cd10277 10 NWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGGKQRGQES-------QPIVNDGVMYVTTSYNRVFAIDAKTGKE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 245 KWRFDPKLKTDKSFQ-HLTCRGVMYYDannttefatslqskkssstqcpRKVFVPVNDGRLVAVNADTGKACTDfgqngq 323
Cdd:cd10277 83 LWKYKHRLPEDIRPCcDVVNRGVALYG----------------------DKVYFGTLDAHLVALDAKTGKVVWK------ 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 324 VNLQEfmpyaYPGGYNPTS-PGIVTGstVVIAGSVTDNYSNKepsGVIRGYDVNTGKLLWVFDT--GAADP-NAMPGEGT 399
Cdd:cd10277 135 KKVAD-----YKAGYSMTLaPLVVKG--KVIVGVSGGEFGVR---GFIAALDAETGKEVWRTYTvpGPGEPgSTDTWPGD 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 400 TFVHNSPNAWAPLAYDAKLDIVYVptGVGTPDIWGGDRTELKERYANSMLAINASTGKLVWNFQTTHHDLWDMDVPSQPS 479
Cdd:cd10277 205 AWKTGGGATWLTGTYDPETNLLYW--GVGNPAPWNGDLRPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPV 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 480 LADIKnKAGQTVPAIYVLTKTGNAFVLDRRNGQpivpvtekpvpqtvkrgpqtkgefYSKTQPFSdlnlapqDKLTDKDM 559
Cdd:cd10277 283 LFDYT-KNGKPVKALVHADRNGFFYVLDRTNGK------------------------LIWATPFV-------KKITWASI 330
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 560 WGATmldqlmCRVsfkrlnydgIYTPPSENGTL-----VFPGNLGVFEWGGMSVNPDRqvavmnpiGLPFVsrlipadPN 634
Cdd:cd10277 331 DLKT------GRP---------IYDEDKVPPKKgktvdFCPSFLGGKNWPPMAYSPDT--------GLFYV-------PA 380
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 635 RAQTAKGAGTEQGVQPmyGVPY---GVEIsaflsplgLPCKQPAWGYVAGVDLKTHEVVWKKRigtirdslpnlFQLPAv 711
Cdd:cd10277 381 NHWCMDLTGEPVSYKK--GAAYlgaGFTI--------KPPFEDHIGELQAIDPTTGKKVWEHK-----------TPLPL- 438
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 118558 712 kigvpgLGGSISTAGNVMFVGaTQDNYLRAFNVTNGKKLWEARLPAGGQATPMTYEINGKQYVVIMAG 779
Cdd:cd10277 439 ------WGGVLTTAGGLVFTG-TPDGYFRAFDAKTGKELWEFQTGSGIIGPPVTWEVDGKQYVAVLSG 499
|
|
| PQQ_enz_alc_DH |
TIGR03075 |
PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic ... |
164-779 |
6.17e-70 |
|
PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Genes in this family often are found adjacent to the PQQ biosynthesis genes themselves. An unusual, strained disulfide bond between adjacent Cys residues contributes to PQQ-binding, as does a Trp residue that is part of a PQQ enzyme repeat (see pfam01011). Characterized members include the dehydrogenase subunit of a membrane-anchored, three subunit alcohol (ethanol) dehydrogenase of Gluconobacter suboxydans, a homodimeric ethanol dehydrogenase in Pseudomonas aeruginosa, and the large subunit of an alpha2/beta2 heterotetrameric methanol dehydrogenase in Methylobacterium extorquens.
Pssm-ID: 274419 [Multi-domain] Cd Length: 527 Bit Score: 239.50 E-value: 6.17e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 164 SDWPAYGRTQAGVRYSPLKQINDQNVKDLKVAWTLRTGDLKtdndsgetTNQVTPIKIGNNMFICTAHQQLIAIDPATGK 243
Cdd:TIGR03075 19 SDWLTYGGGYAGQRYSPLDQINTDNVKKLQPAWTFSLGKQR--------GQESQPLVVDGVMYVTTSYSRVYALDAKTGK 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 244 EKWRFDPKLKTDKsFQHLTC----RGVMYYDAnnttefatslqskkssstqcprKVFVPVNDGRLVAVNADTGKAC--TD 317
Cdd:TIGR03075 91 ILWKYDPKLPDDI-IPVMCCdvvnRGAALYDG----------------------KVFFGTLDARLVALDAKTGKVVwsKK 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 318 FGQngqvnlqefmpyaYPGGYNPTS-PGIVTGstVVIAGSVTDNYSNKepsGVIRGYDVNTGKLLWVF------------ 384
Cdd:TIGR03075 148 NGD-------------YKKGYTITAaPLVVKG--KVITGISGGEFGVR---GYVTAYDAKTGKLVWRRytvpgdmgylkk 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 385 --DTGAADPNAMPGEGTTFVHNSPNAWAPLAYDAKLDIVYVptGVGTPDIWGGDRTELKERYANSMLAINASTGKLVWNF 462
Cdd:TIGR03075 210 tgKPVGGDPGAKTWPGDAWKTGGGATWGTGSYDPETNLIYF--GTGNPAPWNSHLRPGDNLYTSSIVARDPDTGKIKWHY 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 463 QTTHHDLWDMDVPSQPSLADIKnKAGQTVPAIYVLTKTGNAFVLDRRNGQPIVpvtekpvpqtvkrgpqtkgefysktqp 542
Cdd:TIGR03075 288 QTTPHDEWDYDGVNEMILFDLK-KDGKPRKLLAHADRNGFFYVLDRTNGKLLS--------------------------- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 543 fsdlnlapQDKLTDKDMWgATMLDqlmcrVSFKRLNYDGIYTPPSE---NGTLVFPGNLGVFEWGGMSVNPDRqvavmnp 619
Cdd:TIGR03075 340 --------AEPFVDKVNW-ATGVD-----LKTGRPIEVPEARSTDGkkgKPVEVCPGFLGGKNWQPMAYSPKT------- 398
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 620 iGLPFVSrlipadpnrAQTAKGAGTEQGVQPMYGVPY-GVEISAFlsplglPCKQPAWGYVAGVDLKTHEVVWkkrigti 698
Cdd:TIGR03075 399 -GLFYVP---------ANHVCMDYWPEKVSYKKGAAYlGAGFTIK------PPPDDHIGSLIAWDPITGKIVW------- 455
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 699 rdSLPNLFqlpavkigvPGLGGSISTAGNVMFVGaTQDNYLRAFNVTNGKKLWEARLPAGGQATPMTYEINGKQYVVIMA 778
Cdd:TIGR03075 456 --EHKEDF---------PLWGGVLATAGDLVFTG-TLEGYFKAFDAKTGEELWKFKTGSGIVGPPVTYEQDGKQYVAVLS 523
|
.
gi 118558 779 G 779
Cdd:TIGR03075 524 G 524
|
|
| PQQ_ADH_II |
cd10279 |
PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of ... |
164-795 |
2.05e-69 |
|
PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of monomeric and soluble type II alcohol dehydrogenases utilizes pyrroloquinoline quinone (PQQ) as a cofactor and is related to ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller.
Pssm-ID: 199837 [Multi-domain] Cd Length: 549 Bit Score: 238.70 E-value: 2.05e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 164 SDWPAYGRTQAGVRYSPLKQINDQNVKDLKVAWTLRTGDlktdNDSGETTnqvtPIKIGNNMFICTAHQQLIAIDPATGK 243
Cdd:cd10279 1 GNWLSYGRDYDEQRFSPLTQINRSNVGQLGLAWYFDLDT----NRGQEAT----PLVVDGVMYVSGPWSVVYALDARTGK 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 244 EKWRFDPKLktDKSFQHLTC-----RGVMYYDAnnttefatslqskkssstqcprKVFVPVNDGRLVAVNADTGKActdf 318
Cdd:cd10279 73 LLWQYDPEV--DRESGRKACcdvvnRGVAVWDG----------------------KVFVGTLDGRLIALDAKTGKE---- 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 319 gqngQVNLQEFMPYAYpggYNPTSPGIVTGSTVVIAGSVTDnysnkepSGViRG----YDVNTGKLLWVFDTGAADPNAm 394
Cdd:cd10279 125 ----VWSVDTIDPRKP---YTITGAPRVAKGKVVIGNGGAE-------FGV-RGyvsaYDAETGKLVWRFYTVPGNPAK- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 395 PGEGTTFVHNSP--------------NAWAPLAYDAKLDIVYVPTGVGTPdiW--------GGDrtelkERYANSMLAIN 452
Cdd:cd10279 189 PFEHASLEAAAAtwwtgewwrtggggTVWDSITYDPELDLLYIGTGNGSP--WnrkvrspgGGD-----NLFLSSIVALD 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 453 ASTGKLVWNFQTTHHDLWDMDVPSQPSLADIKnKAGQTVPAIYVLTKTGNAFVLDRRNGQ-----PIVPVTekpvpqtvk 527
Cdd:cd10279 262 ADTGRYKWHYQTTPGDTWDYTATQPIILADLE-IDGKPRKVLMHAPKNGFFYVLDRATGKllsaePFVPVN--------- 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 528 rgpqtkgefysktqpfsdlnlapqdkltdkdmWgATMLDQLMCRvsfkrlnydGIYTPPSE---NGTLVFPGNLGVFEWG 604
Cdd:cd10279 332 --------------------------------W-ATGIDLKTGR---------PIENPEARytkGPKLVFPGPLGAHNWH 369
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 605 GMSVNPDRQVAVMNPIGLPFVSRLIPADPNRAQTAKGAGTEQGVQPMYGVPYGVEISAFLSPLglpckqPAWgyvagvDL 684
Cdd:cd10279 370 PMSYNPDTGLVYIPAQEIPAVYEDDPGDFGYNPLGWNTGITPDATPPPAAAKRALRKATRGRL------VAW------DP 437
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 685 KTHEVVWKkrigtirdslpnlfqlpaVKIGVPGLGGSISTAGNVMFVGaTQDNYLRAFNVTNGKKLWEARLPAGGQATPM 764
Cdd:cd10279 438 VTQKAAWR------------------VEHPGPWNGGVLATAGNLVFQG-TADGELAAYDARTGEKLWSFDTGSGIVAAPM 498
|
650 660 670
....*....|....*....|....*....|.
gi 118558 765 TYEINGKQYVVIMAGGHGSFGTKMGDYLVAY 795
Cdd:cd10279 499 TYSVDGEQYVAVLAGWGGAGALSGGPPGAAG 529
|
|
| PQQ_MDH |
cd10278 |
Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the ... |
166-779 |
1.63e-56 |
|
Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the utilization of C1 compounds as a source of energy and carbon by bacteria. It catalyzes the oxidation of methanol to formaldehyde, transfering two electrons per methanol to cytochrome c(L) as the acceptor. Methanol dehydrogenase belongs to a family of dehydrogenases with pyrroloquinoline quinone (PQQ) as cofactor, which also includes dehydrogenases specific to other alcohols and membrane-bound glucose dehydrogenases. This alignment model for the large subunit contains an 8-bladed beta-propeller; the functional enzyme forms a heterotetramer composed of two large and two small subunits.
Pssm-ID: 199836 [Multi-domain] Cd Length: 553 Bit Score: 203.33 E-value: 1.63e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 166 WPAYGRTQAGVRYSPLKQINDQNVKDLKVAWTLRTGDLKtdndsgetTNQVTPIKIGNNMFICTAH-QQLIAID-PATGK 243
Cdd:cd10278 1 WVMPGKDYANTRYSPLAQINKDNVKNLKVAWTFSTGVLR--------GHEGAPLVVGDTMYVVTPFpNNVYALDlNDPGK 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 244 EKWRFDPklKTDKSFQHLTC-----RGVMYYDAnnttefatslqskkssstqcprKVFVPVNDGRLVAVNADTGKACTDF 318
Cdd:cd10278 73 ILWKYKP--KQDPSAVAVACcdvvnRGLAYADG----------------------KIFFNQLDGHLVALDAKTGKEVWKV 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 319 gQNGQVNLQEFMPYAypggynptsPGIVTGStvVIAGSVTDNYSNKepsGVIRGYDVNTGKLLW-VFDTG-------AAD 390
Cdd:cd10278 129 -KNGDPKVGETLTMA---------PLVVKDK--VIVGISGGEFGVR---GYVTAYDLKTGKLVWrAYSTGpdkdvliGPD 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 391 ---PNAMPGEGTTFVHNSPN---------AWAPLAYDAKLDIVYVptGVGTPDIWGGDRTELKERYANSMLAINASTGKL 458
Cdd:cd10278 194 fnpFNPHDGGKDLGLSTWPGdawkigggtNWGWYSYDPKLNLVYY--GTGNPGPWNPTQRPGDNKWSMTIFARDPDTGEA 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 459 VWNFQTTHHDLWDMDVPSQPSLADIKnKAGQTVPAIYVLTKTGNAFVLDRRNGQPIvpVTEKPVPQTVKRGPQTKgefys 538
Cdd:cd10278 272 KWAYQMTPHDEWDYDGVNEMILVDQT-VDGKKRKLLVHFDRNGFVYTLDRTTGELL--SAEKFDPVNNWKGVDLK----- 343
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 539 ktqpfsdlnlapqDKLTDKDMWGATMLDqlmcrvsfkrlnydgiytppsENGTLVFPGNLGVFEWGGMSVNPDRQVAVM- 617
Cdd:cd10278 344 -------------TGRPVKDPEKSTHMD---------------------HNVTDICPSAMGGKDQQPSSYSPKTGLFYVp 389
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 618 -NPIGL---PFVSrlipadPNRAQTakgagteqgvqpmygvPY-GVEISAFLSPLGLPCKQPAWGYVAGvdlkthEVVWk 692
Cdd:cd10278 390 tNHLCMdyePFEV------NYTAGQ----------------PYvGATLAMYPGPGGHMGQFKAWDPVTG------KTKW- 440
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 693 krigTIRDSLPNlfqlpavkigvpgLGGSISTAGNVMFVGaTQDNYLRAFNVTNGKKLWEARLPAGGQATPMTYEINGKQ 772
Cdd:cd10278 441 ----EIKERFPV-------------WSGTLATAGGLVFYG-TLDGWFKAVDAKTGKLLWKFKLPSGIIGNPITYKHDGKQ 502
|
....*..
gi 118558 773 YVVIMAG 779
Cdd:cd10278 503 YVAVLSG 509
|
|
| PQQ |
COG1520 |
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ... |
179-514 |
7.16e-05 |
|
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441129 [Multi-domain] Cd Length: 370 Bit Score: 45.96 E-value: 7.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 179 SPLKQINDQnvKDLKVAWTLRTGDLktdndSGETTNQVTPIKIGNNMFICTAHQQLIAIDPATGKEKWRFDPKLKtdksf 258
Cdd:COG1520 21 APLPEFEPS--VKVKQLWSASVGDG-----VGKGYSRLAPAVAGDRVYAADADGRVAALDAATGKELWRVDLGEP----- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 259 qhLTcRGVMYYDannttefatslqskkssstqcpRKVFVPVNDGRLVAVNADTGKACTDFGQNGQVnlqefmpyaypggy 338
Cdd:COG1520 89 --LS-GGVGADG----------------------GLVVVGTEDGEVIALDADDGEELWRARLSSEV-------------- 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 339 npTSPGIVTGSTVVIAGSvtdnysnkepSGVIRGYDVNTGKLLWVFDT--------GAADPnaMPGEGTTFVhnspnAWA 410
Cdd:COG1520 130 --LAAPAVAGGRVVVRTG----------DGRVYALDAATGERLWSYQRpvpaltlrGTSSP--VIVGGAVLV-----GFA 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 411 playDAKLDIVYVPTG-------VGTPDiwGgdRTELkER-------------------YANSMLAINASTGKLVW--NF 462
Cdd:COG1520 191 ----NGKLVALDLANGqplweqrVAQPR--G--RTEL-ERlvdvdgtpvvdggvvyavaYQGRLAALDLRSGRVLWsrDL 261
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 118558 463 QTTHhdlwDMDVPSQpsladiknkagqtvpAIYVLTKTGNAFVLDRRNGQPI 514
Cdd:COG1520 262 SSYT----GLAVDGN---------------NLYVTDDDGRVWALDRRNGAEL 294
|
|
| BamB_YfgL |
cd10276 |
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ... |
191-460 |
3.10e-04 |
|
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.
Pssm-ID: 199834 [Multi-domain] Cd Length: 358 Bit Score: 43.86 E-value: 3.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 191 DLKVAWTLRTGDlktdndSGETTNQVTPIKIGNNMFICTAHQQLIAIDPATGKEKWRFDPKlKTDKSFQHLTCRG----- 265
Cdd:cd10276 13 DPEVLWSKSVGN------GGMAGIDLTPVVAGDMVYAADANGQVSAFNATTGKIIWETSLS-GKGFLGGTPAVGNgkifv 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 266 ------VMYYDANNTTE-FATSLQskkSSSTQCPR-----KVFVPVNDGRLVAVNADTGKactdfgqngqvnLQEFMPYA 333
Cdd:cd10276 86 gtesgyLYALDAKDGSElWRTEVS---DSQLLSPPtyadgKIYVGTGDGRLYYCNAETGK------------VVWNRTST 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 334 YPGGYnptSPGivtGSTVVIAgsvTDNYSNKEPSGVIRGYDVNTGKLLWVFDTGaadpnampgegttfvhnSPNAWAPLA 413
Cdd:cd10276 151 APELS---LRG---GAAPVGA---YDVVFVGDGNGTVVALNTGTGVDIWEFSVS-----------------EPRGRTELP 204
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 118558 414 YDAKLDIVYVPtgvgtpdiwGGDRTELkERYANSMLAINASTGKLVW 460
Cdd:cd10276 205 RMIDSSVTYVV---------VGGYLYS-TSYQGYLVALDFESGQFLW 241
|
|
| PQQ_2 |
pfam13360 |
PQQ-like domain; This domain contains several repeats of the PQQ repeat. |
677-781 |
4.26e-04 |
|
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
Pssm-ID: 433144 [Multi-domain] Cd Length: 233 Bit Score: 42.78 E-value: 4.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 677 GYVAGVDLKTHEVVWKKRIGTirdslpnlfqlpavkigvpGLGGSISTAGNVMFVgATQDNYLRAFNVTNGKKLWEARLP 756
Cdd:pfam13360 3 GVVTALDAATGAELWRVDLET-------------------GLGGGVAVDGGRLFV-ATGGGQLVALDAATGKLLWRQTLS 62
|
90 100
....*....|....*....|....*
gi 118558 757 AGGQATPmtyEINGKQYVVIMAGGH 781
Cdd:pfam13360 63 GEVLGAP---LVAGGRVFVVAGDGS 84
|
|
| PQQ_2 |
pfam13360 |
PQQ-like domain; This domain contains several repeats of the PQQ repeat. |
366-514 |
4.97e-04 |
|
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
Pssm-ID: 433144 [Multi-domain] Cd Length: 233 Bit Score: 42.39 E-value: 4.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 366 PSGVIRGYDVNTGKLLWVFDTGAAdPNAMPG--EGTTFVHNSPNAWAplAYDAKldivyvpTG------------VGTPD 431
Cdd:pfam13360 1 ADGVVTALDAATGAELWRVDLETG-LGGGVAvdGGRLFVATGGGQLV--ALDAA-------TGkllwrqtlsgevLGAPL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 432 IWGGdrTELKERYANSMLAINASTGKLVWNFQTTHHDLWdmdVPSQPSLAdiknKAGQTVpaiYVLTKTGNAFVLDRRNG 511
Cdd:pfam13360 71 VAGG--RVFVVAGDGSLIALDAADGRRLWSYQRSGEPLA---LRSSGSPA----VVGDTV---VAGFSSGKLVALDPATG 138
|
...
gi 118558 512 QPI 514
Cdd:pfam13360 139 KVR 141
|
|
| PQQ |
pfam01011 |
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller ... |
223-251 |
5.84e-04 |
|
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilize pyrrolo-quinoline quinone as a prosthetic group.
Pssm-ID: 395799 [Multi-domain] Cd Length: 36 Bit Score: 37.94 E-value: 5.84e-04
10 20
....*....|....*....|....*....
gi 118558 223 NNMFICTAHQQLIAIDPATGKEKWRFDPK 251
Cdd:pfam01011 1 GTVYLGSDDGYLYALDAETGKVLWSFKTG 29
|
|
| PQQ |
COG1520 |
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ... |
677-757 |
1.04e-03 |
|
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441129 [Multi-domain] Cd Length: 370 Bit Score: 42.11 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 677 GYVAGVDLKTHEVVWKKRIGTirdslpnlfqlpavkigvpGLGGSISTAGNVMFVGaTQDNYLRAFNVTNGKKLWEARLP 756
Cdd:COG1520 67 GRVAALDAATGKELWRVDLGE-------------------PLSGGVGADGGLVVVG-TEDGEVIALDADDGEELWRARLS 126
|
.
gi 118558 757 A 757
Cdd:COG1520 127 S 127
|
|
| PQQ |
pfam01011 |
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller ... |
727-763 |
1.23e-03 |
|
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilize pyrrolo-quinoline quinone as a prosthetic group.
Pssm-ID: 395799 [Multi-domain] Cd Length: 36 Bit Score: 37.17 E-value: 1.23e-03
10 20 30
....*....|....*....|....*....|....*..
gi 118558 727 NVMFVGaTQDNYLRAFNVTNGKKLWEARLPAGGQATP 763
Cdd:pfam01011 1 GTVYLG-SDDGYLYALDAETGKVLWSFKTGGAVLSSP 36
|
|
| SLC5sbd |
cd10322 |
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ... |
14-88 |
1.94e-03 |
|
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.
Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 41.39 E-value: 1.94e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 118558 14 TVIIIGLLALFLLIGGIWLATLGGSIYYIIAGVLLLIVAWQLYKRASTALWFYAALMLGTIIWSVWEVGTDFWAL 88
Cdd:cd10322 360 AVVVVGVLALLLALLPPSILLLLSLAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLLPLASPL 434
|
|
| ABC-2_lan_permease_MutE_EpiE-like |
cd21807 |
lantibiotic immunity ABC transporter MutE/EpiE family permease (also called ABC-2 transporter ... |
20-90 |
2.19e-03 |
|
lantibiotic immunity ABC transporter MutE/EpiE family permease (also called ABC-2 transporter MutE/EpiE family permease) subunit; This subfamily includes lantibiotic ABC transporter permease subunits EpiE, MutE, SlvE and NisE, which are highly hydrophobic, integral membrane proteins, and part of the bacitracin ABC transport system that confers resistance to the Gram-positive bacteria in which this system operates, specifically to the lantibiotics mutacin, epidermin, nisin and salivaricin, respectively. Lantibiotics are small peptides, produced by Gram-positive bacteria, which are ribosomally-synthesized as pre-peptides and act by disrupting membrane integrity. Genes encoding the lantibiotic ABC transporter subunits are highly organized in operons containing all the genes required for maturation, transport, immunity, and synthesis. For example, in Staphylococcus epidermidis Tu3298, the lantibiotic epidermin is active against other Gram-positive bacteria via various modes of actions; however, its self-protection against the pore-forming epidermin is mediated by the ABC transporter immunity proteins composed of EpiF, EpiE and EpiG; the EpiE permease subunit transports epidermin to the surface and expels it from the membrane. This subfamily also includes the lantibiotic ABC transporter permease subunits MutE, SlvF, and NisE. Self-protection of the mutacin-producing strain Streptococcus mutans CH43 against the pore-forming lantibiotic mutacin is mediated by an ABC transporter composed of MutF, MutE and MutG. In salivaricin D-producing strain Streptococcus salivarius 5M6c, self-immunity against the intrinsically trypsin-resistant salivaricin is mediated via ABC transporter proteins SlvF, SlvE and SlvG, while in Lactococcus lactis, self-immunity against nisin is mediated by the ABC transporter NisFEG. The MutE, NisE and SlvF permease subunits transport mutacin, nisin and salivaricin, respectively to the surface and expel them from the membrane.
Pssm-ID: 409632 Cd Length: 234 Bit Score: 40.57 E-value: 2.19e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 118558 20 LLALFLLIGGIWLATLGGSIYYIIAGVLLLIVA--WQ--LYKRASTALWFYAALMLGTIIWSVWEV---GTDFWALAP 90
Cdd:cd21807 101 ILFVLLLLGGLLLGGGISPPISILLASLLLWLTslWQipLCLFLAKKFGMFVTIIINVLLGLLLGVllaTTSYWWLIP 178
|
|
| DUF308 |
pfam03729 |
Short repeat of unknown function (DUF308); Family of short repeats that occurs in a limited ... |
16-75 |
2.86e-03 |
|
Short repeat of unknown function (DUF308); Family of short repeats that occurs in a limited number of membrane proteins. It may divide further in short repeats of around 7-10 residues of the pattern G-#-X(2)-#(2)-X (#=hydrophobic).
Pssm-ID: 427468 Cd Length: 73 Bit Score: 37.10 E-value: 2.86e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 118558 16 IIIGLLALFL-LIGGIWLATLGGsIYYIIAGVLLLIVAWQLYKRASTALWFYAALMLGTII 75
Cdd:pfam03729 7 IILGILALIWpGAALLALVILIG-ILLLVSGILQLIAAFALRKFGGGGFWWLLLSGILYLI 66
|
|
| assembly_YfgL |
TIGR03300 |
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ... |
677-757 |
3.01e-03 |
|
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274511 [Multi-domain] Cd Length: 377 Bit Score: 40.69 E-value: 3.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 677 GYVAGVDLKTHEVVWKKRIGTirdslpnlfqlpavkigvpGLGGSISTAGNVMFVGaTQDNYLRAFNVTNGKKLWEARLP 756
Cdd:TIGR03300 75 GTVAALDAETGKRLWRVDLDE-------------------RLSGGVGADGGLVFVG-TEKGEVIALDAEDGKELWRAKLS 134
|
.
gi 118558 757 A 757
Cdd:TIGR03300 135 S 135
|
|
| PQQ |
pfam01011 |
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller ... |
366-394 |
3.61e-03 |
|
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilize pyrrolo-quinoline quinone as a prosthetic group.
Pssm-ID: 395799 [Multi-domain] Cd Length: 36 Bit Score: 35.63 E-value: 3.61e-03
10 20
....*....|....*....|....*....
gi 118558 366 PSGVIRGYDVNTGKLLWVFDTGAADPNAM 394
Cdd:pfam01011 8 DDGYLYALDAETGKVLWSFKTGGAVLSSP 36
|
|
| BamB_YfgL |
cd10276 |
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ... |
677-774 |
3.76e-03 |
|
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.
Pssm-ID: 199834 [Multi-domain] Cd Length: 358 Bit Score: 40.39 E-value: 3.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118558 677 GYVAGVDLKTHEVVWKKrigtirdslpnlfqlpavKIGVPGLGGSISTAGNVMFVGATQDNYLRAFNVTNGKKLWEARLP 756
Cdd:cd10276 48 GQVSAFNATTGKIIWET------------------SLSGKGFLGGTPAVGNGKIFVGTESGYLYALDAKDGSELWRTEVS 109
|
90
....*....|....*...
gi 118558 757 AGGQATPMTYEiNGKQYV 774
Cdd:cd10276 110 DSQLLSPPTYA-DGKIYV 126
|
|
| PQQ |
smart00564 |
beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline ... |
217-249 |
7.39e-03 |
|
beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline quinone (PQQ) as cofactor, in Ire1p-like Ser/Thr kinases, and in prokaryotic dehydrogenases.
Pssm-ID: 128836 [Multi-domain] Cd Length: 33 Bit Score: 34.82 E-value: 7.39e-03
10 20 30
....*....|....*....|....*....|...
gi 118558 217 TPIKIGNNMFICTAHQQLIAIDPATGKEKWRFD 249
Cdd:smart00564 1 PVVLSDGTVYVGSTDGTLYALDAKTGEILWTYK 33
|
|
| |
