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Conserved domains on  [gi|1174743667|gb|OQV12109|]
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hypothetical protein BV898_13588 [Hypsibius exemplaris]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182789)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 491-584 4.21e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.32  E-value: 4.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174743667 491 PVLTVKAVDDDSDQFMPLDYFLsfeLAPCLQGFMEIDRSTGVVSVVKPLDREATgmnETLVVEVFVMDNAKQSfnqLTSR 570
Cdd:cd11304    15 VVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQ---SSYTLTVTATDGGGPP---LSST 85

                          90
                  ....*....|....
gi 1174743667 571 AsKIAFRVTDLNDN 584
Cdd:cd11304    86 A-TVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 242-331 1.89e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.78  E-value: 1.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174743667 242 VEAEDDDSEEFMPLNYFLSYDEAPqleGYVEINITTGVVSVVRPLDREAPgmaELMMLTIRVMDNAnrgyNQQTSAGTRI 321
Cdd:cd11304    19 VSATDPDSGENGEVTYSIVSGNED---GLFSIDPSTGEITTAKPLDREEQ---SSYTLTVTATDGG----GPPLSSTATV 88

                          90
                  ....*....|
gi 1174743667 322 AFRVIDRNDN 331
Cdd:cd11304    89 TITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 781-832 2.85e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 48.89  E-value: 2.85e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1174743667  781 GQLMVRRSLDRETVATILAIVTVTDQAaeePRPQTVTTMVSITVNDLNDNPP 832
Cdd:smart00112  33 GEITTTKPLDREEQPEYTLTVEATDGG---GPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 863-947 1.91e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 38.45  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174743667 863 LYASDRDSvPKTPPFFHEILNLDPiyQNHIAVETgDNGLIRVKTLLPFEyrLIQRLTFQLVIRDaKEGFAMRATVTVTLV 942
Cdd:cd11304    19 VSATDPDS-GENGEVTYSIVSGNE--DGLFSIDP-STGEITTAKPLDRE--EQSSYTLTVTATD-GGGPPLSSTATVTIT 91


                  ....*
gi 1174743667 943 IIDVN 947
Cdd:cd11304    92 VLDVN 96
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 491-584 4.21e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.32  E-value: 4.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174743667 491 PVLTVKAVDDDSDQFMPLDYFLsfeLAPCLQGFMEIDRSTGVVSVVKPLDREATgmnETLVVEVFVMDNAKQSfnqLTSR 570
Cdd:cd11304    15 VVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQ---SSYTLTVTATDGGGPP---LSST 85

                          90
                  ....*....|....
gi 1174743667 571 AsKIAFRVTDLNDN 584
Cdd:cd11304    86 A-TVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 242-331 1.89e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.78  E-value: 1.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174743667 242 VEAEDDDSEEFMPLNYFLSYDEAPqleGYVEINITTGVVSVVRPLDREAPgmaELMMLTIRVMDNAnrgyNQQTSAGTRI 321
Cdd:cd11304    19 VSATDPDSGENGEVTYSIVSGNED---GLFSIDPSTGEITTAKPLDREEQ---SSYTLTVTATDGG----GPPLSSTATV 88

                          90
                  ....*....|
gi 1174743667 322 AFRVIDRNDN 331
Cdd:cd11304    89 TITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 244-333 1.10e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.04  E-value: 1.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174743667  244 AEDDDSEEFMPLNYFLSYDEAPqleGYVEINITTGVVSVVRPLDREAPGMAElmmLTIRVMDNAnrgyNQQTSAGTRIAF 323
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDD---GLFSIDPETGEITTTKPLDREEQPEYT---LTVEATDGG----GPPLSSTATVTI 71

                           90
                   ....*....|
gi 1174743667  324 RVIDRNDNPP 333
Cdd:smart00112  72 TVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 496-586 1.76e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.66  E-value: 1.76e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174743667  496 KAVDDDSDQFMPLDYFLsfeLAPCLQGFMEIDRSTGVVSVVKPLDREATgmnETLVVEVFVMDNAKQSfnqLTSRASkIA 575
Cdd:smart00112   1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQ---PEYTLTVEATDGGGPP---LSSTAT-VT 70

                           90
                   ....*....|.
gi 1174743667  576 FRVTDLNDNPP 586
Cdd:smart00112  71 ITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 781-832 2.85e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 48.89  E-value: 2.85e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1174743667  781 GQLMVRRSLDRETVATILAIVTVTDQAaeePRPQTVTTMVSITVNDLNDNPP 832
Cdd:smart00112  33 GEITTTKPLDREEQPEYTLTVEATDGG---GPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 781-830 5.02e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 48.85  E-value: 5.02e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1174743667 781 GQLMVRRSLDRETVATILAIVTVTDQAaeePRPQTVTTMVSITVNDLNDN 830
Cdd:cd11304    52 GEITTAKPLDREEQSSYTLTVTATDGG---GPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
239-310 5.02e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.98  E-value: 5.02e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1174743667 239 FLAVEAEDDDSeefmPLNYFLSYDEAPQ-LEGYVEINITTGVVSVVRPLDREAPGMAElmmLTIRVMDNANRG 310
Cdd:pfam00028  15 VLTVTATDPDL----GPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESIGEYE---LTVEATDSGGPP 80
Cadherin pfam00028
Cadherin domain;
491-563 6.79e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.59  E-value: 6.79e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1174743667 491 PVLTVKAVDDDSDQFMPLDYFLSFELAPclqGFMEIDRSTGVVSVVKPLDREATGMNEtlvVEVFVMDNAKQS 563
Cdd:pfam00028  14 EVLTVTATDPDLGPNGRIFYSILGGGPG---GNFRIDPDTGDISTTKPLDRESIGEYE---LTVEATDSGGPP 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 863-947 1.91e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 38.45  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174743667 863 LYASDRDSvPKTPPFFHEILNLDPiyQNHIAVETgDNGLIRVKTLLPFEyrLIQRLTFQLVIRDaKEGFAMRATVTVTLV 942
Cdd:cd11304    19 VSATDPDS-GENGEVTYSIVSGNE--DGLFSIDP-STGEITTAKPLDRE--EQSSYTLTVTATD-GGGPPLSSTATVTIT 91


                  ....*
gi 1174743667 943 IIDVN 947
Cdd:cd11304    92 VLDVN 96
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 491-584 4.21e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.32  E-value: 4.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174743667 491 PVLTVKAVDDDSDQFMPLDYFLsfeLAPCLQGFMEIDRSTGVVSVVKPLDREATgmnETLVVEVFVMDNAKQSfnqLTSR 570
Cdd:cd11304    15 VVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQ---SSYTLTVTATDGGGPP---LSST 85

                          90
                  ....*....|....
gi 1174743667 571 AsKIAFRVTDLNDN 584
Cdd:cd11304    86 A-TVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 242-331 1.89e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.78  E-value: 1.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174743667 242 VEAEDDDSEEFMPLNYFLSYDEAPqleGYVEINITTGVVSVVRPLDREAPgmaELMMLTIRVMDNAnrgyNQQTSAGTRI 321
Cdd:cd11304    19 VSATDPDSGENGEVTYSIVSGNED---GLFSIDPSTGEITTAKPLDREEQ---SSYTLTVTATDGG----GPPLSSTATV 88

                          90
                  ....*....|
gi 1174743667 322 AFRVIDRNDN 331
Cdd:cd11304    89 TITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 244-333 1.10e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.04  E-value: 1.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174743667  244 AEDDDSEEFMPLNYFLSYDEAPqleGYVEINITTGVVSVVRPLDREAPGMAElmmLTIRVMDNAnrgyNQQTSAGTRIAF 323
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDD---GLFSIDPETGEITTTKPLDREEQPEYT---LTVEATDGG----GPPLSSTATVTI 71

                           90
                   ....*....|
gi 1174743667  324 RVIDRNDNPP 333
Cdd:smart00112  72 TVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 496-586 1.76e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.66  E-value: 1.76e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174743667  496 KAVDDDSDQFMPLDYFLsfeLAPCLQGFMEIDRSTGVVSVVKPLDREATgmnETLVVEVFVMDNAKQSfnqLTSRASkIA 575
Cdd:smart00112   1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQ---PEYTLTVEATDGGGPP---LSSTAT-VT 70

                           90
                   ....*....|.
gi 1174743667  576 FRVTDLNDNPP 586
Cdd:smart00112  71 ITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 781-832 2.85e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 48.89  E-value: 2.85e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1174743667  781 GQLMVRRSLDRETVATILAIVTVTDQAaeePRPQTVTTMVSITVNDLNDNPP 832
Cdd:smart00112  33 GEITTTKPLDREEQPEYTLTVEATDGG---GPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 781-830 5.02e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 48.85  E-value: 5.02e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1174743667 781 GQLMVRRSLDRETVATILAIVTVTDQAaeePRPQTVTTMVSITVNDLNDN 830
Cdd:cd11304    52 GEITTAKPLDREEQSSYTLTVTATDGG---GPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
239-310 5.02e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.98  E-value: 5.02e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1174743667 239 FLAVEAEDDDSeefmPLNYFLSYDEAPQ-LEGYVEINITTGVVSVVRPLDREAPGMAElmmLTIRVMDNANRG 310
Cdd:pfam00028  15 VLTVTATDPDL----GPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESIGEYE---LTVEATDSGGPP 80
Cadherin pfam00028
Cadherin domain;
491-563 6.79e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.59  E-value: 6.79e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1174743667 491 PVLTVKAVDDDSDQFMPLDYFLSFELAPclqGFMEIDRSTGVVSVVKPLDREATGMNEtlvVEVFVMDNAKQS 563
Cdd:pfam00028  14 EVLTVTATDPDLGPNGRIFYSILGGGPG---GNFRIDPDTGDISTTKPLDRESIGEYE---LTVEATDSGGPP 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 863-947 1.91e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 38.45  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174743667 863 LYASDRDSvPKTPPFFHEILNLDPiyQNHIAVETgDNGLIRVKTLLPFEyrLIQRLTFQLVIRDaKEGFAMRATVTVTLV 942
Cdd:cd11304    19 VSATDPDS-GENGEVTYSIVSGNE--DGLFSIDP-STGEITTAKPLDRE--EQSSYTLTVTATD-GGGPPLSSTATVTIT 91


                  ....*
gi 1174743667 943 IIDVN 947
Cdd:cd11304    92 VLDVN 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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