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Conserved domains on  [gi|1145104707|gb|OOB41277|]
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AsnC family transcriptional regulator [Burkholderia cenocepacia]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
3-142 4.92e-49

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 154.55  E-value: 4.92e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145104707   3 ELDHFDLALLDVLQRFGRATHQQLGEEVPLSPSQIGRRLQRLEAAGVIEGYRVMLRPEKLGLGVTAFTSLKLKHHGdsiI 82
Cdd:COG1522     2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHR---L 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145104707  83 EQFQQQIDVLPEVLECHAVVGDADYLLRIVAPDLNALSQFVMKKLMRVPGVDSVRSNIVL 142
Cdd:COG1522    79 DEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
3-142 4.92e-49

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 154.55  E-value: 4.92e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145104707   3 ELDHFDLALLDVLQRFGRATHQQLGEEVPLSPSQIGRRLQRLEAAGVIEGYRVMLRPEKLGLGVTAFTSLKLKHHGdsiI 82
Cdd:COG1522     2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHR---L 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145104707  83 EQFQQQIDVLPEVLECHAVVGDADYLLRIVAPDLNALSQFVMKKLMRVPGVDSVRSNIVL 142
Cdd:COG1522    79 DEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 4-113 1.04e-31

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 109.53  E-value: 1.04e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145104707    4 LDHFDLALLDVLQRFGRATHQQLGEEVPLSPSQIGRRLQRLEAAGVIEGYRVMLRPEKLGLGVTAFTSLKLKHHGDsiIE 83
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDK--LE 78

                           90       100       110
                   ....*....|....*....|....*....|
gi 1145104707   84 QFQQQIDVLPEVLECHAVVGDADYLLRIVA 113
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
3-156 2.30e-28

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 102.92  E-value: 2.30e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145104707   3 ELDHFDLALLDVLQRFGRATHQQLGEEVPLSPSQIGRRLQRLEAAGVIEGYRVMLRPEKLGLGVTAFTSLKLKHHGDSII 82
Cdd:PRK11169   11 DLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVF 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1145104707  83 EQFQQQIDVLPEVLECHAVVGDADYLLRIVAPDLNALSQFVMKKLMRVPGVDSVRSNIVLTTFKRNGALPLAHL 156
Cdd:PRK11169   91 EQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQTNRLVIKTR 164
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 74-144 1.87e-20

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 79.88  E-value: 1.87e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1145104707  74 LKHHGDSIIEQFQQQIDVLPEVLECHAVVGDADYLLRIVAPDLNALSQFVMKKLMRVPGVDSVRSNIVLTT 144
Cdd:pfam01037   3 VKLEPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 5-54 4.44e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.20  E-value: 4.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1145104707   5 DHFDLALLDVLQRfGRATHQQLGEEVPLSPSQIGRRLQRLEAAGVIEGYR 54
Cdd:cd00090     6 DPTRLRILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRR 54
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
3-142 4.92e-49

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 154.55  E-value: 4.92e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145104707   3 ELDHFDLALLDVLQRFGRATHQQLGEEVPLSPSQIGRRLQRLEAAGVIEGYRVMLRPEKLGLGVTAFTSLKLKHHGdsiI 82
Cdd:COG1522     2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHR---L 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145104707  83 EQFQQQIDVLPEVLECHAVVGDADYLLRIVAPDLNALSQFVMKKLMRVPGVDSVRSNIVL 142
Cdd:COG1522    79 DEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 4-113 1.04e-31

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 109.53  E-value: 1.04e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145104707    4 LDHFDLALLDVLQRFGRATHQQLGEEVPLSPSQIGRRLQRLEAAGVIEGYRVMLRPEKLGLGVTAFTSLKLKHHGDsiIE 83
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDK--LE 78

                           90       100       110
                   ....*....|....*....|....*....|
gi 1145104707   84 QFQQQIDVLPEVLECHAVVGDADYLLRIVA 113
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
3-156 2.30e-28

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 102.92  E-value: 2.30e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145104707   3 ELDHFDLALLDVLQRFGRATHQQLGEEVPLSPSQIGRRLQRLEAAGVIEGYRVMLRPEKLGLGVTAFTSLKLKHHGDSII 82
Cdd:PRK11169   11 DLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVF 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1145104707  83 EQFQQQIDVLPEVLECHAVVGDADYLLRIVAPDLNALSQFVMKKLMRVPGVDSVRSNIVLTTFKRNGALPLAHL 156
Cdd:PRK11169   91 EQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQTNRLVIKTR 164
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 74-144 1.87e-20

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 79.88  E-value: 1.87e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1145104707  74 LKHHGDSIIEQFQQQIDVLPEVLECHAVVGDADYLLRIVAPDLNALSQFVMKKLMRVPGVDSVRSNIVLTT 144
Cdd:pfam01037   3 VKLEPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-142 1.78e-14

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 66.66  E-value: 1.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145104707   1 MLELDHFDLALLDVLQRFGRATHQQLGEEVPLSPSQIGRRLQRLEAAGVIEGYRVMLRPEKLGLGVTAFTSLKLKHHGD- 79
Cdd:PRK11179    4 NYQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSAKDy 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1145104707  80 -SIIEQFQQqidvLPEVLECHAVVGDADYLLRIVAPDLNALSQFVMKKLMRVPGVDSVRSNIVL 142
Cdd:PRK11179   84 pSALAKLES----LDEVVEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLISL 143
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
5-45 1.10e-09

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 50.83  E-value: 1.10e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1145104707   5 DHFDLALLDVLQRFGRATHQQLGEEVPLSPSQIGRRLQRLE 45
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
6-50 8.28e-08

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 46.27  E-value: 8.28e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1145104707   6 HFDLALLDVLQRFGRATHQQLGEEVPLSPSQIGRRLQRLEAAGVI 50
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 3-55 5.71e-04

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 36.82  E-value: 5.71e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1145104707   3 ELDHFDLALLDVL-QRFGRATHQQLGEEVPLSPSQIGRRLQRLEAAGVIEGYRV 55
Cdd:COG2512    12 ELLEDERRVLELLrENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERV 65
Rfk COG1339
Archaeal CTP-dependent riboflavin kinase [Coenzyme transport and metabolism]; Archaeal ...
 9-51 3.84e-03

Archaeal CTP-dependent riboflavin kinase [Coenzyme transport and metabolism]; Archaeal CTP-dependent riboflavin kinase is part of the Pathway/BioSystem: Riboflavin/FAD biosynthesis


Pssm-ID: 440950 [Multi-domain]  Cd Length: 219  Bit Score: 36.36  E-value: 3.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1145104707   9 LALLDVLQRFGRATHQQLGEEVPLSPSQIGRRLQRLEAAGVIE 51
Cdd:COG1339    11 LALLGALKGPVKISSSELAKRLGISQQTASRRLQELEDAGLIE 53
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 5-54 4.44e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.20  E-value: 4.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1145104707   5 DHFDLALLDVLQRfGRATHQQLGEEVPLSPSQIGRRLQRLEAAGVIEGYR 54
Cdd:cd00090     6 DPTRLRILRLLLE-GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRR 54
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-51 5.51e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 35.33  E-value: 5.51e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1145104707   2 LELDHFDLALLDVLQRFGRATHQQLGEEVPLSPSQIGRRLQRLEAAGVIE 51
Cdd:COG1846    34 LGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
10-62 8.57e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 35.28  E-value: 8.57e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1145104707  10 ALLDVLQRFGRATHQQLGEEVPLSPSQIGRRLQRLEAAGVIEGYRV---MLRPEKL 62
Cdd:COG2345    17 RILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERETErrgRGRPAKL 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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