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Conserved domains on  [gi|1145088310|gb|OOB25309|]
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TetR family transcriptional regulator [Burkholderia cenocepacia]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
8-146 4.98e-14

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 66.46  E-value: 4.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145088310   8 NSRERILAAATRLAQTHGYGGLNYRDLANEVGIKAASIYHHFESKADLGAAVARRYREDSAAALDDMLARSrDPLDCLRR 87
Cdd:COG1309     6 ATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAE-DPRERLRA 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1145088310  88 YPGTFRKALEtgNRLCLCSFMAAETDDLPEvVMKEVLAFADVNVAWLSKVLSAAAVVGA 146
Cdd:COG1309    85 LLRAYLEFLA--ENPALARLLLAEAAELPE-LRAALRALLRRLRALLAELLRAGGLLAD 140
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
8-146 4.98e-14

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 66.46  E-value: 4.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145088310   8 NSRERILAAATRLAQTHGYGGLNYRDLANEVGIKAASIYHHFESKADLGAAVARRYREDSAAALDDMLARSrDPLDCLRR 87
Cdd:COG1309     6 ATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAE-DPRERLRA 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1145088310  88 YPGTFRKALEtgNRLCLCSFMAAETDDLPEvVMKEVLAFADVNVAWLSKVLSAAAVVGA 146
Cdd:COG1309    85 LLRAYLEFLA--ENPALARLLLAEAAELPE-LRAALRALLRRLRALLAELLRAGGLLAD 140
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
13-59 4.61e-09

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 50.10  E-value: 4.61e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1145088310  13 ILAAATRLAQTHGYGGLNYRDLANEVGIKAASIYHHFESKADLGAAV 59
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK14996 PRK14996
TetR family transcriptional regulator; Provisional
 10-59 1.96e-05

TetR family transcriptional regulator; Provisional


Pssm-ID: 184958 [Multi-domain]  Cd Length: 192  Bit Score: 43.16  E-value: 1.96e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1145088310  10 RERILAAATRLAQTHGYGGLNYRDLANEVGIKAASIYHHFESKADLGAAV 59
Cdd:PRK14996   10 REVILQAAMRVALAEGFAAMTVRRIASEAQVAAGQVHHHFSSAGELKALA 59
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
8-146 4.98e-14

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 66.46  E-value: 4.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1145088310   8 NSRERILAAATRLAQTHGYGGLNYRDLANEVGIKAASIYHHFESKADLGAAVARRYREDSAAALDDMLARSrDPLDCLRR 87
Cdd:COG1309     6 ATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAE-DPRERLRA 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1145088310  88 YPGTFRKALEtgNRLCLCSFMAAETDDLPEvVMKEVLAFADVNVAWLSKVLSAAAVVGA 146
Cdd:COG1309    85 LLRAYLEFLA--ENPALARLLLAEAAELPE-LRAALRALLRRLRALLAELLRAGGLLAD 140
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
13-59 4.61e-09

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 50.10  E-value: 4.61e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1145088310  13 ILAAATRLAQTHGYGGLNYRDLANEVGIKAASIYHHFESKADLGAAV 59
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
10-88 4.24e-07

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 48.01  E-value: 4.24e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1145088310  10 RERILAAATRLAQTHGYGGLNYRDLANEVGIKAASIYHHFESKADLGAAVARRYREDSAAALDDMLARSRDPLDCLRRY 88
Cdd:COG3226    10 RERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLEDAAEAL 88
PRK14996 PRK14996
TetR family transcriptional regulator; Provisional
 10-59 1.96e-05

TetR family transcriptional regulator; Provisional


Pssm-ID: 184958 [Multi-domain]  Cd Length: 192  Bit Score: 43.16  E-value: 1.96e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1145088310  10 RERILAAATRLAQTHGYGGLNYRDLANEVGIKAASIYHHFESKADLGAAV 59
Cdd:PRK14996   10 REVILQAAMRVALAEGFAAMTVRRIASEAQVAAGQVHHHFSSAGELKALA 59
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 9-55 1.02e-03

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 38.45  E-value: 1.02e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1145088310   9 SRERILAAATRLAQTHGYGGLNYRDLANEVGIKAASIYHHFESKADL 55
Cdd:PRK10668   12 TRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDL 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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