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Conserved domains on  [gi|1125431357|gb|OLD60412|]
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hypothetical protein AUF60_01225 [Gemmatimonadetes bacterium 13_1_20CM_69_28]

Protein Classification

UbiA prenyltransferase family protein( domain architecture ID 91)

UbiA prenyltransferase family protein, an aromatic prenyltransferase, plays an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PT_UbiA super family cl00337
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 5-269 2.81e-31

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


The actual alignment was detected with superfamily member cd13961:

Pssm-ID: 469727  Cd Length: 270  Bit Score: 116.83  E-value: 2.81e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357   5 LRLVRAHNLVVAAAGVLAGGWIALGVLATPKLLLFAAVAAVGLGAAGNAAN--DIWDADADRVNRrPDeRPLAAGHLSRG 82
Cdd:cd13961     3 LELIRPPNLLMAALAQYLGALFALGPLLSLNDLELLLLFLSVFLIAAAGYIinDYFDVEIDRINK-PD-RPIPSGRISRR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357  83 TADLCVVGGILLGVGAAALVGGGAVLVGLAALGVMLVYSPMLKRRGFAGNLAVALVAGLPLEYGALAVG-RPAAGVVPWV 161
Cdd:cd13961    81 EALILSILLNALGLILAFLLSPLALLIALLNSLLLWLYSHKLKRTPLIGNLLVALLTGLPFLFGGLAAGnLLLIILLLAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357 162 LAAWLHLVREIVKDLGDEPGDRVVGRRTLPVVIGSRATALLAAGLGVGFVPASLLLPLAARYGAAYYLIALFAQLAVLLV 241
Cdd:cd13961   161 FAFLITLGREIVKDIEDVEGDRAEGARTLPIVYGIKKAKKIAALLLLLAILLSPLPYLLGGLGILYLILIIIADLLFLYS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1125431357 242 ASRLITG--RLHRNSLLLKGAMIVGIVALV 269
Cdd:cd13961   241 AIRLAKSpkDYSKLSKLLKLAMLLGLLAFL 270
 
Name Accession Description Interval E-value
PT_UbiA_DGGGPS cd13961
Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate ...
 5-269 2.81e-31

Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate synthase (DGGGPS) transfers a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate, as part of the isoprenoid ether lipid biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260124  Cd Length: 270  Bit Score: 116.83  E-value: 2.81e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357   5 LRLVRAHNLVVAAAGVLAGGWIALGVLATPKLLLFAAVAAVGLGAAGNAAN--DIWDADADRVNRrPDeRPLAAGHLSRG 82
Cdd:cd13961     3 LELIRPPNLLMAALAQYLGALFALGPLLSLNDLELLLLFLSVFLIAAAGYIinDYFDVEIDRINK-PD-RPIPSGRISRR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357  83 TADLCVVGGILLGVGAAALVGGGAVLVGLAALGVMLVYSPMLKRRGFAGNLAVALVAGLPLEYGALAVG-RPAAGVVPWV 161
Cdd:cd13961    81 EALILSILLNALGLILAFLLSPLALLIALLNSLLLWLYSHKLKRTPLIGNLLVALLTGLPFLFGGLAAGnLLLIILLLAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357 162 LAAWLHLVREIVKDLGDEPGDRVVGRRTLPVVIGSRATALLAAGLGVGFVPASLLLPLAARYGAAYYLIALFAQLAVLLV 241
Cdd:cd13961   161 FAFLITLGREIVKDIEDVEGDRAEGARTLPIVYGIKKAKKIAALLLLLAILLSPLPYLLGGLGILYLILIIIADLLFLYS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1125431357 242 ASRLITG--RLHRNSLLLKGAMIVGIVALV 269
Cdd:cd13961   241 AIRLAKSpkDYSKLSKLLKLAMLLGLLAFL 270
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 2-273 5.08e-24

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 97.99  E-value: 5.08e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357   2 IDVLRLVRAHNLVVAAAGVLAGGWIALGVLATPKLLLFAAVAAVGLGAAGNAANDIWDADADRVNRRPDERPLAAGHLSR 81
Cdd:COG0382     4 LRLLRLDRPIGILLLLWPTLWALFLAAGGLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLASGRISL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357  82 GTADLCVVGGILLGVGAAALVGGGAVLVGLAALGVMLVYSPMLKRRGFAGNLAVALVAGLPLEYGALAVGR--PAAGVVP 159
Cdd:COG0382    84 REALLLAIVLLLLALALALLLNPLTFLLALAALALAWAYSLFLKRFTLLGNLVLGLLFGLGILMGFAAVTGslPLSAWLL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357 160 WVLAAWLHLVREIVKDLGDEPGDRVVGRRTLPVVIGSRATALLAAGLGVGFVPASLLLPLAARYGAAYYLIALFAQLAVL 239
Cdd:COG0382   164 ALAAFLWTLAYDTIYDLEDREGDRKIGIKTLAILFGVRDALIIAGVLYALAVLLLLLLGLLAGLGLLYLLGLLAALLLLY 243

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1125431357 240 LVASRLITGRLHRNSL---LLKGAMIVGIVALVAGRI 273
Cdd:COG0382   244 LSQLWLLRPRKKDPARalkLFKLNMLLGLLLFLGIAL 280
ubiA PRK12882
prenyltransferase; Reviewed
 5-272 3.67e-23

prenyltransferase; Reviewed


Pssm-ID: 183811  Cd Length: 276  Bit Score: 95.42  E-value: 3.67e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357   5 LRLVRAHNLVVAAAGVLAGGWIALGVLATPKLLLFAAVAAVGLGAAGNAANDIWDADADRVNRrPDeRPLAAGHLSRGTA 84
Cdd:PRK12882    8 LELTRPVNAVVAGVAAFIGAFIAGGILSSPSLTGLAFAAVFLATGAGNAINDYFDREIDRINR-PD-RPIPSGAVSPRGA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357  85 DLCVVGGILLGVGAAALVGGGAVLVGLAALGVMLVYSPMLKRRGFAGNLAVALVAGLPLEYGALAVGR--PAAGVVPWVL 162
Cdd:PRK12882   86 LAFSILLFAAGVALAFLLPPLCLAIALFNSLLLVLYAETLKGTPGLGNASVAYLTGSTFLFGGAAVGTegLLALLVLFAL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357 163 AAWLHLVREIVKDLGDEPGDRVVGRRTLPVVIGSRATALLAAGLGVGFVPASLLLPLAARYGAAYYLIALFAQLAVLLVA 242
Cdd:PRK12882  166 AALATLAREIIKDVEDIEGDRAEGARTLPILIGVRKALYVAAAFLLVAVAASPLPYLLSTFGLWYLVLVAPADLVMLAAA 245

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1125431357 243 SR-LITGRLHRNSLLLKGAMIVGIVALVAGR 272
Cdd:PRK12882  246 YRsLKKTDPTASQKLLKYGMFLALAAFIVGR 276
UbiA pfam01040
UbiA prenyltransferase family;
16-245 2.23e-13

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 68.02  E-value: 2.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357  16 AAAGVLAGGWIALGVLATPKLLLFAAVAAVGLGAAGNAANDIWDADADRVNRRPDERPLAAGHLSRGTADLCVVGGILLG 95
Cdd:pfam01040   1 LLIPALAGLALAAGGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357  96 VGAAALVGGGAVLVGLAALGVMLVYSPMLKRRGFAGNLAVALVAGLPLEYGALAV-GRPAAGVVPWVLAAWLH-LVREIV 173
Cdd:pfam01040  81 LLLLLLLNPLTALLGLAALLLYVLYTLRLKRRTLLGQLVGGLAFGLPPLLGWAAVtGSLSPLALLLALALFLWtWAIALA 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1125431357 174 KDLGDEPGDRVVGRRTLPVVIGSRATALLAAGLGVGFVPASLLLPLAARYGAAYYLIALFAQLAVLLVASRL 245
Cdd:pfam01040 161 NDLRDREDDRKAGIKTLPVVLGRKAARILLALLLAVALLLLLLLLLLLLGGLYLLLALLLAALALLYAARLL 232
 
Name Accession Description Interval E-value
PT_UbiA_DGGGPS cd13961
Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate ...
 5-269 2.81e-31

Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate synthase (DGGGPS) transfers a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate, as part of the isoprenoid ether lipid biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260124  Cd Length: 270  Bit Score: 116.83  E-value: 2.81e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357   5 LRLVRAHNLVVAAAGVLAGGWIALGVLATPKLLLFAAVAAVGLGAAGNAAN--DIWDADADRVNRrPDeRPLAAGHLSRG 82
Cdd:cd13961     3 LELIRPPNLLMAALAQYLGALFALGPLLSLNDLELLLLFLSVFLIAAAGYIinDYFDVEIDRINK-PD-RPIPSGRISRR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357  83 TADLCVVGGILLGVGAAALVGGGAVLVGLAALGVMLVYSPMLKRRGFAGNLAVALVAGLPLEYGALAVG-RPAAGVVPWV 161
Cdd:cd13961    81 EALILSILLNALGLILAFLLSPLALLIALLNSLLLWLYSHKLKRTPLIGNLLVALLTGLPFLFGGLAAGnLLLIILLLAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357 162 LAAWLHLVREIVKDLGDEPGDRVVGRRTLPVVIGSRATALLAAGLGVGFVPASLLLPLAARYGAAYYLIALFAQLAVLLV 241
Cdd:cd13961   161 FAFLITLGREIVKDIEDVEGDRAEGARTLPIVYGIKKAKKIAALLLLLAILLSPLPYLLGGLGILYLILIIIADLLFLYS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1125431357 242 ASRLITG--RLHRNSLLLKGAMIVGIVALV 269
Cdd:cd13961   241 AIRLAKSpkDYSKLSKLLKLAMLLGLLAFL 270
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 2-273 5.08e-24

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 97.99  E-value: 5.08e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357   2 IDVLRLVRAHNLVVAAAGVLAGGWIALGVLATPKLLLFAAVAAVGLGAAGNAANDIWDADADRVNRRPDERPLAAGHLSR 81
Cdd:COG0382     4 LRLLRLDRPIGILLLLWPTLWALFLAAGGLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLASGRISL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357  82 GTADLCVVGGILLGVGAAALVGGGAVLVGLAALGVMLVYSPMLKRRGFAGNLAVALVAGLPLEYGALAVGR--PAAGVVP 159
Cdd:COG0382    84 REALLLAIVLLLLALALALLLNPLTFLLALAALALAWAYSLFLKRFTLLGNLVLGLLFGLGILMGFAAVTGslPLSAWLL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357 160 WVLAAWLHLVREIVKDLGDEPGDRVVGRRTLPVVIGSRATALLAAGLGVGFVPASLLLPLAARYGAAYYLIALFAQLAVL 239
Cdd:COG0382   164 ALAAFLWTLAYDTIYDLEDREGDRKIGIKTLAILFGVRDALIIAGVLYALAVLLLLLLGLLAGLGLLYLLGLLAALLLLY 243

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1125431357 240 LVASRLITGRLHRNSL---LLKGAMIVGIVALVAGRI 273
Cdd:COG0382   244 LSQLWLLRPRKKDPARalkLFKLNMLLGLLLFLGIAL 280
ubiA PRK12882
prenyltransferase; Reviewed
 5-272 3.67e-23

prenyltransferase; Reviewed


Pssm-ID: 183811  Cd Length: 276  Bit Score: 95.42  E-value: 3.67e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357   5 LRLVRAHNLVVAAAGVLAGGWIALGVLATPKLLLFAAVAAVGLGAAGNAANDIWDADADRVNRrPDeRPLAAGHLSRGTA 84
Cdd:PRK12882    8 LELTRPVNAVVAGVAAFIGAFIAGGILSSPSLTGLAFAAVFLATGAGNAINDYFDREIDRINR-PD-RPIPSGAVSPRGA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357  85 DLCVVGGILLGVGAAALVGGGAVLVGLAALGVMLVYSPMLKRRGFAGNLAVALVAGLPLEYGALAVGR--PAAGVVPWVL 162
Cdd:PRK12882   86 LAFSILLFAAGVALAFLLPPLCLAIALFNSLLLVLYAETLKGTPGLGNASVAYLTGSTFLFGGAAVGTegLLALLVLFAL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357 163 AAWLHLVREIVKDLGDEPGDRVVGRRTLPVVIGSRATALLAAGLGVGFVPASLLLPLAARYGAAYYLIALFAQLAVLLVA 242
Cdd:PRK12882  166 AALATLAREIIKDVEDIEGDRAEGARTLPILIGVRKALYVAAAFLLVAVAASPLPYLLSTFGLWYLVLVAPADLVMLAAA 245

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1125431357 243 SR-LITGRLHRNSLLLKGAMIVGIVALVAGR 272
Cdd:PRK12882  246 YRsLKKTDPTASQKLLKYGMFLALAAFIVGR 276
ubiA PRK12884
prenyltransferase; Reviewed
 5-273 9.43e-22

prenyltransferase; Reviewed


Pssm-ID: 183812  Cd Length: 279  Bit Score: 91.56  E-value: 9.43e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357   5 LRLVRAHNLVVAAAGVLAGGWIALGVLATPKLLLfAAVAAVGLGAAGNAANDIWDADADRVNRrpDERPLAAGHLSRGTA 84
Cdd:PRK12884    8 LELLRPEHGLMAGIAVVLGAIIALGGLPLDEALL-GFLTAFFASGSANALNDYFDYEVDRINR--PDRPIPSGRISRREA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357  85 DLCVVGGILLGVGAAALVGGGAVLVGLAALGVMLVYSPMLKRRGFAGNLAVALVAGLPLEYGALAVGRPAAGVvpWVLAA 164
Cdd:PRK12884   85 LLLAILLFILGLIAAYLISPLAFLVVILVSVLGILYNWKLKEYGLIGNLYVAFLTGMTFIFGGIAVGELNEAV--ILLAA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357 165 WLHLV---REIVKDLGDEPGDRVVGRRTLPVVIGSRATALLAAGLGVGFVPASLLLPLAARYGAAYYLIALFAQLAVLLV 241
Cdd:PRK12884  163 MAFLMtlgREIMKDIEDVEGDRLRGARTLAILYGEKIAGRIAAALFILAVLLSPLPYLFGIFNILYLAPVLVADLIFLYS 242

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1125431357 242 ASRLITGR----LHRNSLLLKGAMIVGIVALVAGRI 273
Cdd:PRK12884  243 AYSLLRSQdretIRKVRKITLTAMLLALVAFALGAI 278
ubiA PRK12883
prenyltransferase UbiA-like protein; Reviewed
 5-273 1.33e-19

prenyltransferase UbiA-like protein; Reviewed


Pssm-ID: 171796  Cd Length: 277  Bit Score: 85.94  E-value: 1.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357   5 LRLVRAHNLVVAAAGVLAGGWIALGVLATPKLLLFAAVAAVGLGAAGNAANDIWDADADRVNRrpDERPLAAGHLSRGTA 84
Cdd:PRK12883    7 IEITRPHNCILAGIVGILGSLVALGGIPPIKTLILIFLVVYLGCSGGNTINDYFDYEIDKINR--PNRPLPRGAMSRKAA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357  85 DLCVVGGILLGVGAAALVGGGAVLVGLAALGVMLVYSPMLKRRGFAGNLAVALVAGLPLEYGALAVGRPAAGVVPWVLAA 164
Cdd:PRK12883   85 LYYSLLLFAVGLALAYLINIEAFLFALGAYVLMFLYAWKLKPLPFIGNVVVALLTGATPIYGAIAVGRIGLAGYLAICAF 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357 165 WLHLVREIVKDLGDEPGDRVVGRRTLPVVIGSRATALLAAGLGVGFVPASlLLPLAARYGAAYYLIALFAQL---AVLLV 241
Cdd:PRK12883  165 LVNVAREIMKDIEDIEGDKAKGAKTLPIIIGKKRAAYIGAIFGVLTVIAS-FLPVKAGIGLGYLPIIIVDAIilyAAYLV 243

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1125431357 242 ASRLITGRLHRNSLLLKGAMIVGIVALVAGRI 273
Cdd:PRK12883  244 LRNPDRETAHKGQKLLKIAIFLAVISFLLGAL 275
PRK09573 PRK09573
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Reviewed
 5-273 2.23e-19

(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Reviewed


Pssm-ID: 181963  Cd Length: 279  Bit Score: 85.01  E-value: 2.23e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357   5 LRLVRAHNLVVAAAGVLAGGWIALGVLATPKLLLFAAVAAVGLGAAGNAANDIWDADADRVNRrpDERPLAAGHLSRGTA 84
Cdd:PRK09573    7 FELIRPKNCIGASIGAIIGYLIASNFKIDLKGIILAALVVFLVCAGGNVINDIYDIEIDKINK--PERPIPSGRISLKEA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357  85 DLCVVGGILLGVGAAALVGGGAVLVGLAALGVMLVYSPMLKRRGFAGNLAVALVAGLPLEYGALAVGRPAAGVVPWVLAA 164
Cdd:PRK09573   85 KIFSITLFIVGLILSIFINIYAFLIALLNSILLYLYAKDLKKTGLIGNLIVAYLTGLSFIFGGLAVFNVLRIIILFLCAF 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357 165 WLHLVREIVKDLGDEPGDRVVGRRTLPVVIGSRATALLAAGLgVGFVPASLLLPLAARYGAAYYLIALFAQLAVLLVASR 244
Cdd:PRK09573  165 FSTWSREIVKDIEDIEGDLKENVITLPIKYGIKKSWYIAKIL-LILAIVLSPLPYFLGIFGIYYLIVVIICDILFIIAML 243

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1125431357 245 LI-----TGRLHRNSLLLKGAMIVGIVALVAGRI 273
Cdd:PRK09573  244 ILlknpsIEGASKASKYLKIIMILGLIAFLIGSL 277
UbiA pfam01040
UbiA prenyltransferase family;
16-245 2.23e-13

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 68.02  E-value: 2.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357  16 AAAGVLAGGWIALGVLATPKLLLFAAVAAVGLGAAGNAANDIWDADADRVNRRPDERPLAAGHLSRGTADLCVVGGILLG 95
Cdd:pfam01040   1 LLIPALAGLALAAGGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357  96 VGAAALVGGGAVLVGLAALGVMLVYSPMLKRRGFAGNLAVALVAGLPLEYGALAV-GRPAAGVVPWVLAAWLH-LVREIV 173
Cdd:pfam01040  81 LLLLLLLNPLTALLGLAALLLYVLYTLRLKRRTLLGQLVGGLAFGLPPLLGWAAVtGSLSPLALLLALALFLWtWAIALA 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1125431357 174 KDLGDEPGDRVVGRRTLPVVIGSRATALLAAGLGVGFVPASLLLPLAARYGAAYYLIALFAQLAVLLVASRL 245
Cdd:pfam01040 161 NDLRDREDDRKAGIKTLPVVLGRKAARILLALLLAVALLLLLLLLLLLLGGLYLLLALLLAALALLYAARLL 232
PT_UbiA cd13956
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 5-269 3.14e-12

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260119 [Multi-domain]  Cd Length: 271  Bit Score: 65.06  E-value: 3.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357   5 LRLVRAHNLVVAAAGVLAGGWIALGV-LATPKLLLFAAVAAVGLGAAGNAANDIWDADADRVNRRpdERPLAAGHLSRGT 83
Cdd:cd13956     1 LRLMRPYTLLYVLAPALAGAALAGAFaGPLPALLLLALLAVFLGAGAGYALNDYTDRELDAINKP--DRPLPSGRLSPRQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357  84 ADLCVVGGILLGVGAAALVGGGAVLVGLAALGVMLVYSPMLKRRGFAGNLAVALVAGLPLEYGALAVGRPAAGVVPWVLA 163
Cdd:cd13956    79 ALAFAAALLLVGLALALALGPLALLLLLAGLLLGLAYSLGLKRLKLGGWGVLGYATGLALLPGLGAVAAGGLVPLALLLA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357 164 A---WLHLVREIVKDLGDEPGDRVVGRRTLPVVIGSRATALLAAGLGVGFVPASLLLPLAARYGAAYYLIALFAQLAVLL 240
Cdd:cd13956   159 LvflLLGLGINLYNDLPDVEGDRAAGIRTLPVRLGPRRARRLAAGLLLAALILVVLLAVAGLLGPLALLALLAVALLALR 238

                         250       260
                  ....*....|....*....|....*....
gi 1125431357 241 VASRLITGRLHRNSLLLKGAMIVGIVALV 269
Cdd:cd13956   239 ARFARADRLPALPRGFLLLAVYRLLLFAA 267
ubiA PRK12872
prenyltransferase; Reviewed
 124-273 1.08e-08

prenyltransferase; Reviewed


Pssm-ID: 237241  Cd Length: 285  Bit Score: 54.95  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357 124 LKRRGFAGNLAVALVAGLPLEYGALAVGRPAAGVVPWVLAAW---LHLVREIVKDLGDEPGDRVVGRRTLPVVIGSRATA 200
Cdd:PRK12872  128 LKRIPLFKNLVVSLLWALSPLILGVYYYQLTIFSLLLLYAVFiflKSFIREIVFDIKDIEGDRKSGLKTLPIVLGKERTL 207

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1125431357 201 LLAAGLGVGFVPASLLLPLAARYGAAYY-LIALFAQLAVLLVASRLITGR--LHRNSLLLKGAMIVGIVALVAGRI 273
Cdd:PRK12872  208 KFLLILNLLFLILLILGVYTGLLPLLLLvLLLLLAYVLYYIIKLFAADDKkdLLYLSLLDKEHMLLGLISMLLGLL 283
PT_UbiA_3 cd13965
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 143-249 6.07e-07

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260128  Cd Length: 273  Bit Score: 49.57  E-value: 6.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357 143 LEYGALAVGRPAAGVVPWVLAAWLHLVREIV------KDLGDEPGDRVVGRRTLPVVIGSRATALLAAglgVGFVPASLL 216
Cdd:cd13965   140 FLAGATRIAGGGPHPLDPTAWAWILLSAAIIlttihaQDFRDVEGDRARGRRTLPLVFGDAAARWLIA---AGVVAWSVV 216

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1125431357 217 LPLAARYGAAYYliALFAQLAvLLVASRLITGR 249
Cdd:cd13965   217 LPYFWGLPPLLA--ALLVALG-AVVAVRFLLLR 246
PT_UbiA_chlorophyll cd13958
Bacteriochlorophyll/chlorophyll synthetase; Chlorophyll synthase catalyzes the last step of ...
 124-237 7.19e-04

Bacteriochlorophyll/chlorophyll synthetase; Chlorophyll synthase catalyzes the last step of chlorophyll (Chl) biosynthesis, the addition of the tetraprenyl (phytyl or geranylgeranyl) side chain. In plant chloroplast, the chlorophyll synthase is located in thylakoid membrane and has been shown to also have a regulatory or channeling function. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260121  Cd Length: 277  Bit Score: 40.29  E-value: 7.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357 124 LKRRGFAGNLAVAL-VAGLPLEYGALAVGRPAAGVVPWV--LAAWLHLVREIVKDLGDEPGDRVVGRRTLPVVIGSRATA 200
Cdd:cd13958   127 LKQNGWWGNAAVGLsYEGLPWWAGAAAFAGLLTWESLALalLYSIGAHGIMTLNDFKSIEGDRQLGLRSLPVALGVDTAA 206

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1125431357 201 LLAAglGVGFVPASLLLPLAARYGAAYYLIALFAQLA 237
Cdd:cd13958   207 WIAC--GVIDVPQLAVAALLLAWGETWYAAVVGALLL 241
PT_UbiA_5 cd13967
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 137-268 5.10e-03

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260130  Cd Length: 277  Bit Score: 37.59  E-value: 5.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431357 137 LVAGLPLEYGALAvgRPAAGVVPWVLAAWLhLVREIVKDLGDEPGDRVVGRRTLPVVIGSRATALLAAGLGV---GFVPA 213
Cdd:cd13967   146 VIALLPALYGQPS--TPSVLVVFLFFFLKV-FVNTAIFDIRDVEGDRIVGIETLPVLLGEERTRLLLLVLNIllaLLLVA 222

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1125431357 214 SLLLPLAArYGAAYYLIALFAQLAVLLVASRLITGRLHRNSLLLKG-AMIVGIVAL 268
Cdd:cd13967   223 GVLLGLLA-SEFLVLLLSLIYGLIYIIFFSRDENEEGLRLELLAGEeFILAGLVAL 277
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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