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Conserved domains on  [gi|1101172367|gb|OIP25611|]
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NADH:ubiquinone oxidoreductase subunit J [Comamonadaceae bacterium CG2_30_60_41]

Protein Classification

NADH-quinone oxidoreductase subunit J( domain architecture ID 11482363)

NADH-quinone oxidoreductase subunit J (NuoJ) is part of the membrane domain of complex I of the respiratory chain that couples the transfer of electrons from NADH to quinone with the translocation of protons across the membrane

Gene Ontology:  GO:0008137|GO:0048038|GO:0016020
PubMed:  36104567|23417064|24059520

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK06638 PRK06638
NADH-quinone oxidoreductase subunit J;
1-199 1.18e-58

NADH-quinone oxidoreductase subunit J;


:

Pssm-ID: 235844 [Multi-domain]  Cd Length: 198  Bit Score: 183.11  E-value: 1.18e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367   1 MSVTSGLFYFFSAILLFAAFRVVTARNPVHAVLFLVLTFFQASLIWMLLKAEFLSLSLILVYVGAVMVLFLFVVMMLDIN 80
Cdd:PRK06638    1 MTGEAIAFYILALLAVLAALGVVTSRNPVHSALFLILTFLSIAGLYFLLGAEFLGVVQIIVYVGAVMVLFLFVVMMLDVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367  81 lESVRQGFWKHFPIAAVVGVFIIFEMSAVLMGGFRVTDDPAIVNNVTAGASNTRELGKLLYTYYIYPLEVAAAILLVGMI 160
Cdd:PRK06638   81 -FSEREQLREWLPGGVLIGLVILLGLLLLLIVGAIIAASGVNAQGIAAGEGNTKAIGILLFTDYLLPFELASVLLLVAMV 159

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1101172367 161 AAIALTLRERKDSKAVKPDDQVRVKAKDRLVVLKVTPTQ 199
Cdd:PRK06638  160 GAIVLARRERARVKRQDVPAQLPDGREDALSVVKVEEGK 198
 
Name Accession Description Interval E-value
PRK06638 PRK06638
NADH-quinone oxidoreductase subunit J;
1-199 1.18e-58

NADH-quinone oxidoreductase subunit J;


Pssm-ID: 235844 [Multi-domain]  Cd Length: 198  Bit Score: 183.11  E-value: 1.18e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367   1 MSVTSGLFYFFSAILLFAAFRVVTARNPVHAVLFLVLTFFQASLIWMLLKAEFLSLSLILVYVGAVMVLFLFVVMMLDIN 80
Cdd:PRK06638    1 MTGEAIAFYILALLAVLAALGVVTSRNPVHSALFLILTFLSIAGLYFLLGAEFLGVVQIIVYVGAVMVLFLFVVMMLDVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367  81 lESVRQGFWKHFPIAAVVGVFIIFEMSAVLMGGFRVTDDPAIVNNVTAGASNTRELGKLLYTYYIYPLEVAAAILLVGMI 160
Cdd:PRK06638   81 -FSEREQLREWLPGGVLIGLVILLGLLLLLIVGAIIAASGVNAQGIAAGEGNTKAIGILLFTDYLLPFELASVLLLVAMV 159

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1101172367 161 AAIALTLRERKDSKAVKPDDQVRVKAKDRLVVLKVTPTQ 199
Cdd:PRK06638  160 GAIVLARRERARVKRQDVPAQLPDGREDALSVVKVEEGK 198
NuoJ COG0839
NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH: ...
 7-169 4.07e-54

NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 6 (chain J) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440601 [Multi-domain]  Cd Length: 162  Bit Score: 170.30  E-value: 4.07e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367   7 LFYFFSAILLFAAFRVVTARNPVHAVLFLVLTFFQASLIWMLLKAEFLSLSLILVYVGAVMVLFLFVVMMLDINLESVRQ 86
Cdd:COG0839     4 LFYIFAALAVASALGVVTSRNPVHAALYLVLTFLSVAGLYLLLGAEFLAAVQVIVYVGAVMVLFLFVVMLLDLDKEELRE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367  87 GFWKHFPIAAVVGVFIIFEMSAVLMGGFrvtdDPAIVNNVTAGASNTRELGKLLYTYYIYPLEVAAAILLVGMIAAIALT 166
Cdd:COG0839    84 GFRKYRPLAALVGLLLLAELAYVLLSTS----WAAAPAAAAAAVGNTKALGELLFTDYLLPFELASVLLLVAMIGAIVLA 159


                  ...
gi 1101172367 167 LRE 169
Cdd:COG0839   160 RRE 162
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
20-165 1.73e-35

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 122.23  E-value: 1.73e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367  20 FRVVTARNPVHAVLFLVLTFFQASLIWMLLKAEFLSLSLILVYVGAVMVLFLFVVMMLDinLESVRQGFWKHFPIAAVVG 99
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLL--AEEEPEKLRSGLPLAALLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1101172367 100 VFIIFemsAVLMGGFRVTDDPAIVNNVTAGASNTRELGKLLYTYYIYPLEVAAAILLVGMIAAIAL 165
Cdd:pfam00499  79 GLLLL---ALLLLVLLSASLTPAAAAAAPDVGNIEAIGELLFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
PRK06638 PRK06638
NADH-quinone oxidoreductase subunit J;
1-199 1.18e-58

NADH-quinone oxidoreductase subunit J;


Pssm-ID: 235844 [Multi-domain]  Cd Length: 198  Bit Score: 183.11  E-value: 1.18e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367   1 MSVTSGLFYFFSAILLFAAFRVVTARNPVHAVLFLVLTFFQASLIWMLLKAEFLSLSLILVYVGAVMVLFLFVVMMLDIN 80
Cdd:PRK06638    1 MTGEAIAFYILALLAVLAALGVVTSRNPVHSALFLILTFLSIAGLYFLLGAEFLGVVQIIVYVGAVMVLFLFVVMMLDVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367  81 lESVRQGFWKHFPIAAVVGVFIIFEMSAVLMGGFRVTDDPAIVNNVTAGASNTRELGKLLYTYYIYPLEVAAAILLVGMI 160
Cdd:PRK06638   81 -FSEREQLREWLPGGVLIGLVILLGLLLLLIVGAIIAASGVNAQGIAAGEGNTKAIGILLFTDYLLPFELASVLLLVAMV 159

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1101172367 161 AAIALTLRERKDSKAVKPDDQVRVKAKDRLVVLKVTPTQ 199
Cdd:PRK06638  160 GAIVLARRERARVKRQDVPAQLPDGREDALSVVKVEEGK 198
NuoJ COG0839
NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH: ...
 7-169 4.07e-54

NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 6 (chain J) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440601 [Multi-domain]  Cd Length: 162  Bit Score: 170.30  E-value: 4.07e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367   7 LFYFFSAILLFAAFRVVTARNPVHAVLFLVLTFFQASLIWMLLKAEFLSLSLILVYVGAVMVLFLFVVMMLDINLESVRQ 86
Cdd:COG0839     4 LFYIFAALAVASALGVVTSRNPVHAALYLVLTFLSVAGLYLLLGAEFLAAVQVIVYVGAVMVLFLFVVMLLDLDKEELRE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367  87 GFWKHFPIAAVVGVFIIFEMSAVLMGGFrvtdDPAIVNNVTAGASNTRELGKLLYTYYIYPLEVAAAILLVGMIAAIALT 166
Cdd:COG0839    84 GFRKYRPLAALVGLLLLAELAYVLLSTS----WAAAPAAAAAAVGNTKALGELLFTDYLLPFELASVLLLVAMIGAIVLA 159


                  ...
gi 1101172367 167 LRE 169
Cdd:COG0839   160 RRE 162
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
20-165 1.73e-35

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 122.23  E-value: 1.73e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367  20 FRVVTARNPVHAVLFLVLTFFQASLIWMLLKAEFLSLSLILVYVGAVMVLFLFVVMMLDinLESVRQGFWKHFPIAAVVG 99
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLL--AEEEPEKLRSGLPLAALLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1101172367 100 VFIIFemsAVLMGGFRVTDDPAIVNNVTAGASNTRELGKLLYTYYIYPLEVAAAILLVGMIAAIAL 165
Cdd:pfam00499  79 GLLLL---ALLLLVLLSASLTPAAAAAAPDVGNIEAIGELLFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00057
NADH dehydrogenase subunit 6; Provisional
 6-175 1.89e-32

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177129 [Multi-domain]  Cd Length: 186  Bit Score: 115.87  E-value: 1.89e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367   6 GLFYFFSAILLFAAFRVVTARNPVHAVLFLVLTFFQASLIWMLLKAEFLSLSLILVYVGAVMVLFLFVVMMLDINLESVR 85
Cdd:MTH00057    3 GLFYLFALGVIISGIMVISALNPVHSVLWLIVAFTSASALFILLEVEFIALIFLIVYVGAIAILFLFVIMMLNLTDLEGG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367  86 QGFWKHFPIAAVVGVFIIFEMSAVLMGGFRVTDDPAI-VNNVTAGASNTRELGKLLYTYYIYPLEVAAAILLVGMIAAIA 164
Cdd:MTH00057   83 GDMSNYLPAGFIIGVVFLFEVSSGISLLSSGTKIGQWdFPNWIEKESNIEVLGRVLYTDYYYLFILASFILLVAMIGAIV 162

                         170
                  ....*....|.
gi 1101172367 165 LTLRERKDSKA 175
Cdd:MTH00057  163 LTHDLIIEIKR 173
ND6 MTH00021
NADH dehydrogenase subunit 6; Validated
 10-167 1.82e-22

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 214401 [Multi-domain]  Cd Length: 188  Bit Score: 89.79  E-value: 1.82e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367  10 FFSAILLFAAFRVVTARNPVHAVLFLVLTFFQASLIWMLLKAEFLSLSLILVYVGAVMVLFLFVVMMLDI-NLESVRQGF 88
Cdd:MTH00021    1 FFSLGIIGSGIMVISALNPVHSIFWLVVVFVNSAVFFILLGLDFLALMFLIIYVGAIAILFLFVIMLLNLtDFPPAFGGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367  89 WKH---FPIAAVVGVFIIFEM--SAVLMGGFRVTDDPAIVNNVTAGASNTRELGKLLYTYYIYPLEVAAAILLVGMIAAI 163
Cdd:MTH00021   81 ADMtnyIPIGLIIGTLFFSEIasSWLIIGGPYVERWDLAFPWFLISYHNIEALGRILYITCYYLFLLASFILLVAMIGAI 160


                  ....
gi 1101172367 164 ALTL 167
Cdd:MTH00021  161 VLTQ 164
ndhG CHL00016
NADH dehydrogenase subunit 6
 2-171 4.47e-12

NADH dehydrogenase subunit 6


Pssm-ID: 214335 [Multi-domain]  Cd Length: 182  Bit Score: 62.23  E-value: 4.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367   2 SVTSGLFYFFSAILLFAAFRVVTARNPVHAVLFLVLTFFQASLIWMLLKAEFLSLSLILVYVGAVMVLFLFVVMML---- 77
Cdd:CHL00016    6 PIHDFLLVFLGSGLILGSLGVVLLTNPIYSAFSLGLVLVCISLFYILLNADFVAAAQLLIYVGAINVLIIFAVMFMngpe 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367  78 ---DINLESVRQGfwkhfpIAAVVGVFIIFEMSAVLM-----GGFRVTDDPAIVNNVTagASNTRELGKLLYTYYIYPLE 149
Cdd:CHL00016   86 yskDFNLWTVGDG------ITSLVCTSLFFSLITTILdtswyGIIWTTRSNQIIEQDL--ISNVQQIGIHLSTDFLLPFE 157

                         170       180
                  ....*....|....*....|..
gi 1101172367 150 VAAAILLVGMIAAIALTLRERK 171
Cdd:CHL00016  158 LISIILLVALIGAITVARQEQV 179
PRK06433 PRK06433
NADH dehydrogenase subunit J; Provisional
 1-76 3.78e-10

NADH dehydrogenase subunit J; Provisional


Pssm-ID: 180562 [Multi-domain]  Cd Length: 88  Bit Score: 54.61  E-value: 3.78e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1101172367   1 MSVTSGLFYFFSAILLFAAFRVVTARNPVHAVLFLVLTFFQASLIWMLLKAEFLSLSLILVYVGAVMVLFLFVVMM 76
Cdd:PRK06433    1 MMYETIAFALFALVTVAFSLGVVLSRDVWHSALYLGVALFSVAVLYVMLNAEFLAAVQVLVYVGAVLILITFAVML 76
ND6 MTH00213
NADH dehydrogenase subunit 6; Provisional
 27-169 8.00e-10

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177256 [Multi-domain]  Cd Length: 239  Bit Score: 56.83  E-value: 8.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367  27 NPVHAVLFLVLTFFQASLIWMLLKAEFLSLSLILVYVGAVMVLFLFVVMMLDINLESVRQGFWKHFP------------- 93
Cdd:MTH00213   22 NFLASVFWLILTFIGSSGLFIVLGMEFLGLIFLIVYVGAICIIFLFVIMMIPGGAKGFKPTKGNKKEkerkkgeetgrig 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101172367  94 ----IAAVVGVFIIFEMSAVL-----------MGGFRV----------------------TDDPAIVNNVT--------- 127
Cdd:MTH00213  102 appaIGILIGAILAAELASAVpdsflnnpsgrGGAERYeltnilsdrnrgvssllgsdkeSITTGIQNNIYmrvgatgap 181

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1101172367 128 ------------AGASNTRELGKLLYTYYIYPLEVAAAILLVGMIAAIALTLRE 169
Cdd:MTH00213  182 ylyndsfftlngSGGTNLEAIGSVLYINYYYAFILVSFILLVAMIGAIVLGLQS 235
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 8-72 5.55e-04

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 39.12  E-value: 5.55e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1101172367   8 FYFFSAILLFAAFRVVTARNPVHAVLFLVLTFFQASLIWMLLKAEFLSLSLILVYVGAVMVLFLF 72
Cdd:MTH00045    3 FYLFLILMLFGSTLVFYSLSPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVY 67
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 10-77 4.82e-03

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 36.51  E-value: 4.82e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1101172367  10 FFSAILLFAAFRVVTARNPVHAVLFLVLTFFQASLIWMLLKAEFLSLSLILVYVGAVMVLFLFVVMML 77
Cdd:MTH00214    7 LLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALA 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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