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Conserved domains on  [gi|1091176342|gb|OHR04933|]
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ATP-dependent 6-phosphofructokinase [Staphylococcus sp. HMSC078A03]

Protein Classification

ATP-dependent 6-phosphofructokinase( domain architecture ID 10011910)

ATP-dependent 6-phosphofructokinase catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committed step of glycolysis

CATH:  3.40.50.450
EC:  2.7.1.11
Gene Ontology:  GO:0003872|GO:0006002|GO:0046872|GO:0005524

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
1-322 0e+00

ATP-dependent 6-phosphofructokinase;


:

Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 563.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   1 MKKIAVLTSGGDSPGMNAAVRAVVRKAIYNNIEVYGIYQGYQGLLDDNIHKLELGSVGDTIQRGGTFLYSARCPQFKEAS 80
Cdd:PRK03202    1 MKRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  81 VRQKGIENLHKRGIEGLVVVGGDGSYRGAQRISEEtkDIKTIGIPGTIDNDINGTDFTIGFDTALNTIIDSVDKIRDTAS 160
Cdd:PRK03202   81 GRAKAIENLKKLGIDALVVIGGDGSYMGAKRLTEH--GIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTAS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 161 SHARTFIVEVMGRDCGDLALWAGLSVGAETILVPEANTDIKDIAEKIESGIKRGKKHSIVMVAEGSMSGQECADQLMKYI 240
Cdd:PRK03202  159 SHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRERGKKHAIIVVAEGVMPAEELAKEIEERT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 241 NVDARVSVLGHIQRGGSPSGADRVLASRLGGYAVDLLMQGRSGQGVGIMNNKLTATPFDEIFNGNDHKFNTDIYELAKEL 320
Cdd:PRK03202  239 GLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGRMVGIQNNKIVHVPIEEAVENMKHPFDKDLYELAKKL 318


                  ..
gi 1091176342 321 SI 322
Cdd:PRK03202  319 SI 320
 
Name Accession Description Interval E-value
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
1-322 0e+00

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 563.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   1 MKKIAVLTSGGDSPGMNAAVRAVVRKAIYNNIEVYGIYQGYQGLLDDNIHKLELGSVGDTIQRGGTFLYSARCPQFKEAS 80
Cdd:PRK03202    1 MKRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  81 VRQKGIENLHKRGIEGLVVVGGDGSYRGAQRISEEtkDIKTIGIPGTIDNDINGTDFTIGFDTALNTIIDSVDKIRDTAS 160
Cdd:PRK03202   81 GRAKAIENLKKLGIDALVVIGGDGSYMGAKRLTEH--GIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTAS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 161 SHARTFIVEVMGRDCGDLALWAGLSVGAETILVPEANTDIKDIAEKIESGIKRGKKHSIVMVAEGSMSGQECADQLMKYI 240
Cdd:PRK03202  159 SHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRERGKKHAIIVVAEGVMPAEELAKEIEERT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 241 NVDARVSVLGHIQRGGSPSGADRVLASRLGGYAVDLLMQGRSGQGVGIMNNKLTATPFDEIFNGNDHKFNTDIYELAKEL 320
Cdd:PRK03202  239 GLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGRMVGIQNNKIVHVPIEEAVENMKHPFDKDLYELAKKL 318


                  ..
gi 1091176342 321 SI 322
Cdd:PRK03202  319 SI 320
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 1-322 8.99e-163

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 457.23  E-value: 8.99e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   1 MKKIAVLTSGGDSPGMNAAVRAVVRKAIYNNIEVYGIYQGYQGLLDDNIHKLELGSVGDTIQRGGTFLYSARCPQFKEAS 80
Cdd:COG0205     1 MKRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKTEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  81 VRQKGIENLHKRGIEGLVVVGGDGSYRGAQRISEEtKDIKTIGIPGTIDNDINGTDFTIGFDTALNTIIDSVDKIRDTAS 160
Cdd:COG0205    81 GREKALENLKKLGIDALVVIGGDGSLDGAAKLAEE-YGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRDTAA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 161 SHARTFIVEVMGRDCGDLALWAGLSVGAETILVPEANTDIKDIAEKIESGIKRGKKHSIVMVAEGSM------------- 227
Cdd:COG0205   160 SHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKLLEKLKERRKRGKGYSIIVVAEGAGdedgeavleadtd 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 228 ---------SGQECADQLMKYINVDARVSVLGHIQRGGSPSGADRVLASRLGGYAVDLLMQGRSGQGVGIMNNKLTATPF 298
Cdd:COG0205   240 afghvrlggIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLEGKTGVMVGIRRGEIVLVPL 319

                         330       340
                  ....*....|....*....|....*.
gi 1091176342 299 DEIFNGNdHKFNT--DIYELAKELSI 322
Cdd:COG0205   320 EEVANKE-KPVDPdsPLIQLARELGI 344
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 2-321 4.96e-159

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 446.86  E-value: 4.96e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   2 KKIAVLTSGGDSPGMNAAVRAVVRKAIYNNIEVYGIYQGYQGLLDDNIHKLELGSVGDTIQRGGTFLYSARCPQFKEASV 81
Cdd:cd00763     1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSARFPEFKDEEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  82 RQKGIENLHKRGIEGLVVVGGDGSYRGAQRISEETkdIKTIGIPGTIDNDINGTDFTIGFDTALNTIIDSVDKIRDTASS 161
Cdd:cd00763    81 QAKAIEQLKKHGIDALVVIGGDGSYMGAMRLTEHG--FPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRDTSSS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 162 HARTFIVEVMGRDCGDLALWAGLSVGAETILVPEANTDIKDIAEKIESGIKRGKKHSIVMVAEGSMSGQECADQLMKYIN 241
Cdd:cd00763   159 HQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGKKHAIVVVAEGVYDVDELAKEIEEATG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 242 VDARVSVLGHIQRGGSPSGADRVLASRLGGYAVDLLMQGRSGQGVGIMNNKLTATPFDEIFNgNDHKFNTDIYELAKELS 321
Cdd:cd00763   239 FETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAGKGGLAVGIQNEQLVHHDIIDAIE-NMKPFKKDWLALAKKLS 317
PFK pfam00365
Phosphofructokinase;
3-275 6.80e-154

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 431.76  E-value: 6.80e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   3 KIAVLTSGGDSPGMNAAVRAVVRKAIYNNIEVYGIYQGYQGLLDDNIHKLELGSVGDTIQRGGTFLYSARCPQFKEASVR 82
Cdd:pfam00365   1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTEEGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  83 QKGIENLHKRGIEGLVVVGGDGSYRGAQRISEEtKDIKTIGIPGTIDNDINGTDFTIGFDTALNTIIDSVDKIRDTASSH 162
Cdd:pfam00365  81 EKIAENLKKLGIDALVVIGGDGSLTGANKLSEE-RGIPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDTASSH 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 163 ARTFIVEVMGRDCGDLALWAGLSVGAETILVPEANTDIKDIAEKIESGiKRGKKHSIVMVAEGSMSGQECADQLMKYINV 242
Cdd:pfam00365 160 NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKEL-RKGKRFSIIVVAEGASDGEFLAKLIEEGTGI 238

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1091176342 243 DARVSVLGHIQRGGSPSGADRVLASRLGGYAVD 275
Cdd:pfam00365 239 ETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
PFKA_ATP TIGR02482
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ...
 3-301 2.66e-152

6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213713 [Multi-domain]  Cd Length: 301  Bit Score: 429.08  E-value: 2.66e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   3 KIAVLTSGGDSPGMNAAVRAVVRKAIYNNIEVYGIYQGYQGLLDDNIHKLELGSVGDTIQRGGTFLYSARCPQFKEASVR 82
Cdd:TIGR02482   1 KIGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLINGKIEPLESKNVSGIIHRGGTILGTARCPEFKTEEVR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  83 QKGIENLHKRGIEGLVVVGGDGSYRGAQRISEEtKDIKTIGIPGTIDNDINGTDFTIGFDTALNTIIDSVDKIRDTASSH 162
Cdd:TIGR02482  81 EKAVENLKKLGIEGLVVIGGDGSYTGAQKLYEE-GGIPVIGLPGTIDNDIPGTDYTIGFDTALNTIIDAVDKIRDTATSH 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 163 ARTFIVEVMGRDCGDLALWAGLSVGAETILVPEANTDIKDIAEKIESGIKRGKKHSIVMVAEGSM--SGQECADQLMKYI 240
Cdd:TIGR02482 160 ERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDIDELIQRLKEQHEAGKKHSIIIVAEGNIvgSAKEVAKKIEEKT 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1091176342 241 NVDARVSVLGHIQRGGSPSGADRVLASRLGGYAVDLLMQGRSGQGVGIMNNKLTATPFDEI 301
Cdd:TIGR02482 240 GIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGGVMIGIQNNKIVTHPIEEA 300
 
Name Accession Description Interval E-value
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
1-322 0e+00

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 563.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   1 MKKIAVLTSGGDSPGMNAAVRAVVRKAIYNNIEVYGIYQGYQGLLDDNIHKLELGSVGDTIQRGGTFLYSARCPQFKEAS 80
Cdd:PRK03202    1 MKRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  81 VRQKGIENLHKRGIEGLVVVGGDGSYRGAQRISEEtkDIKTIGIPGTIDNDINGTDFTIGFDTALNTIIDSVDKIRDTAS 160
Cdd:PRK03202   81 GRAKAIENLKKLGIDALVVIGGDGSYMGAKRLTEH--GIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTAS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 161 SHARTFIVEVMGRDCGDLALWAGLSVGAETILVPEANTDIKDIAEKIESGIKRGKKHSIVMVAEGSMSGQECADQLMKYI 240
Cdd:PRK03202  159 SHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRERGKKHAIIVVAEGVMPAEELAKEIEERT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 241 NVDARVSVLGHIQRGGSPSGADRVLASRLGGYAVDLLMQGRSGQGVGIMNNKLTATPFDEIFNGNDHKFNTDIYELAKEL 320
Cdd:PRK03202  239 GLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGRMVGIQNNKIVHVPIEEAVENMKHPFDKDLYELAKKL 318


                  ..
gi 1091176342 321 SI 322
Cdd:PRK03202  319 SI 320
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 1-322 8.99e-163

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 457.23  E-value: 8.99e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   1 MKKIAVLTSGGDSPGMNAAVRAVVRKAIYNNIEVYGIYQGYQGLLDDNIHKLELGSVGDTIQRGGTFLYSARCPQFKEAS 80
Cdd:COG0205     1 MKRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKTEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  81 VRQKGIENLHKRGIEGLVVVGGDGSYRGAQRISEEtKDIKTIGIPGTIDNDINGTDFTIGFDTALNTIIDSVDKIRDTAS 160
Cdd:COG0205    81 GREKALENLKKLGIDALVVIGGDGSLDGAAKLAEE-YGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRDTAA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 161 SHARTFIVEVMGRDCGDLALWAGLSVGAETILVPEANTDIKDIAEKIESGIKRGKKHSIVMVAEGSM------------- 227
Cdd:COG0205   160 SHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKLLEKLKERRKRGKGYSIIVVAEGAGdedgeavleadtd 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 228 ---------SGQECADQLMKYINVDARVSVLGHIQRGGSPSGADRVLASRLGGYAVDLLMQGRSGQGVGIMNNKLTATPF 298
Cdd:COG0205   240 afghvrlggIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLEGKTGVMVGIRRGEIVLVPL 319

                         330       340
                  ....*....|....*....|....*.
gi 1091176342 299 DEIFNGNdHKFNT--DIYELAKELSI 322
Cdd:COG0205   320 EEVANKE-KPVDPdsPLIQLARELGI 344
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 2-321 4.96e-159

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 446.86  E-value: 4.96e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   2 KKIAVLTSGGDSPGMNAAVRAVVRKAIYNNIEVYGIYQGYQGLLDDNIHKLELGSVGDTIQRGGTFLYSARCPQFKEASV 81
Cdd:cd00763     1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSARFPEFKDEEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  82 RQKGIENLHKRGIEGLVVVGGDGSYRGAQRISEETkdIKTIGIPGTIDNDINGTDFTIGFDTALNTIIDSVDKIRDTASS 161
Cdd:cd00763    81 QAKAIEQLKKHGIDALVVIGGDGSYMGAMRLTEHG--FPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRDTSSS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 162 HARTFIVEVMGRDCGDLALWAGLSVGAETILVPEANTDIKDIAEKIESGIKRGKKHSIVMVAEGSMSGQECADQLMKYIN 241
Cdd:cd00763   159 HQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGKKHAIVVVAEGVYDVDELAKEIEEATG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 242 VDARVSVLGHIQRGGSPSGADRVLASRLGGYAVDLLMQGRSGQGVGIMNNKLTATPFDEIFNgNDHKFNTDIYELAKELS 321
Cdd:cd00763   239 FETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAGKGGLAVGIQNEQLVHHDIIDAIE-NMKPFKKDWLALAKKLS 317
PFK pfam00365
Phosphofructokinase;
3-275 6.80e-154

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 431.76  E-value: 6.80e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   3 KIAVLTSGGDSPGMNAAVRAVVRKAIYNNIEVYGIYQGYQGLLDDNIHKLELGSVGDTIQRGGTFLYSARCPQFKEASVR 82
Cdd:pfam00365   1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTEEGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  83 QKGIENLHKRGIEGLVVVGGDGSYRGAQRISEEtKDIKTIGIPGTIDNDINGTDFTIGFDTALNTIIDSVDKIRDTASSH 162
Cdd:pfam00365  81 EKIAENLKKLGIDALVVIGGDGSLTGANKLSEE-RGIPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDTASSH 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 163 ARTFIVEVMGRDCGDLALWAGLSVGAETILVPEANTDIKDIAEKIESGiKRGKKHSIVMVAEGSMSGQECADQLMKYINV 242
Cdd:pfam00365 160 NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKEL-RKGKRFSIIVVAEGASDGEFLAKLIEEGTGI 238

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1091176342 243 DARVSVLGHIQRGGSPSGADRVLASRLGGYAVD 275
Cdd:pfam00365 239 ETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
PFKA_ATP TIGR02482
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ...
 3-301 2.66e-152

6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213713 [Multi-domain]  Cd Length: 301  Bit Score: 429.08  E-value: 2.66e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   3 KIAVLTSGGDSPGMNAAVRAVVRKAIYNNIEVYGIYQGYQGLLDDNIHKLELGSVGDTIQRGGTFLYSARCPQFKEASVR 82
Cdd:TIGR02482   1 KIGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLINGKIEPLESKNVSGIIHRGGTILGTARCPEFKTEEVR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  83 QKGIENLHKRGIEGLVVVGGDGSYRGAQRISEEtKDIKTIGIPGTIDNDINGTDFTIGFDTALNTIIDSVDKIRDTASSH 162
Cdd:TIGR02482  81 EKAVENLKKLGIEGLVVIGGDGSYTGAQKLYEE-GGIPVIGLPGTIDNDIPGTDYTIGFDTALNTIIDAVDKIRDTATSH 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 163 ARTFIVEVMGRDCGDLALWAGLSVGAETILVPEANTDIKDIAEKIESGIKRGKKHSIVMVAEGSM--SGQECADQLMKYI 240
Cdd:TIGR02482 160 ERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDIDELIQRLKEQHEAGKKHSIIIVAEGNIvgSAKEVAKKIEEKT 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1091176342 241 NVDARVSVLGHIQRGGSPSGADRVLASRLGGYAVDLLMQGRSGQGVGIMNNKLTATPFDEI 301
Cdd:TIGR02482 240 GIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGGVMIGIQNNKIVTHPIEEA 300
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 2-303 1.24e-135

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 388.19  E-value: 1.24e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   2 KKIAVLTSGGDSPGMNAAVRAVVRKAIYNNIEVYGIYQGYQGLLDDNIHKLELGSVGDTIQRGGTFLYSARCPQFKEASV 81
Cdd:cd00363     1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSARCKEFRTEEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  82 RQKGIENLHKRGIEGLVVVGGDGSYRGAQRISEETKD----IKTIGIPGTIDNDINGTDFTIGFDTALNTIIDSVDKIRD 157
Cdd:cd00363    81 RAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPSkyqgFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDRIRD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 158 TASSHARTFIVEVMGRDCGDLALWAGLSVGAETILVPE---ANTDIKDIAEKIESGIKRGKKHSIVMVAEGSM------- 227
Cdd:cd00363   161 TASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEepaADEWEEEMVDVIKKRRERGKRHGIVIVAEGAIdfipkpi 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1091176342 228 SGQECADQLMKYINVDARVSVLGHIQRGGSPSGADRVLASRLGGYAVDLLMQGRSGQGVGIMN---NKLTATPFDEIFN 303
Cdd:cd00363   241 TEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVGIQNlneNQVVRHPLTEAVN 319
PFK_mixed TIGR02483
phosphofructokinase; Members of this family that are characterized, save one, are ...
 3-301 1.62e-101

phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 274155 [Multi-domain]  Cd Length: 324  Bit Score: 301.14  E-value: 1.62e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   3 KIAVLTSGGDSPGMNAAVRAVVRKAIYN-NIEVYGIYQGYQGLLD-DNIHKLELGSVGDTIQRGGTFLYSARCPQFK-EA 79
Cdd:TIGR02483   1 RIGVLTGGGDCPGLNAVIRGVVRRAIAEyGWEVIGIRDGWRGLLEgDTVPLLDLEDVRGILPRGGTILGSSRTNPFKyEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  80 SVRQKGIENLHKRGIEGLVVVGGDGSYRGAQRISEetKDIKTIGIPGTIDNDINGTDFTIGFDTALNTIIDSVDKIRDTA 159
Cdd:TIGR02483  81 DGDDKIVANLKELGLDALIAIGGDGTLGIARRLAD--KGLPVVGVPKTIDNDLEATDYTFGFDTAVEIATEALDRLHTTA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 160 SSHARTFIVEVMGRDCGDLALWAGLSVGAETILVPEANTDIKDIAEKIESGIKRGKKHSIVMVAEGSM------------ 227
Cdd:TIGR02483 159 ESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEIPFDIDSVCEKVRERFARGKRFAIVVVAEGAKpkggemvvqegv 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 228 -----------SGQECADQLMKYINVDARVSVLGHIQRGGSPSGADRVLASRLGGYAVDLLMQGRSGQGVGIMNNKLTAT 296
Cdd:TIGR02483 239 kdafghvrlggIGNWLAEEIERRTGIETRATVLGHLQRGGSPSAFDRVLATRFGVAAVDLVHEGQFGHMVALRGTDIVYV 318


                  ....*
gi 1091176342 297 PFDEI 301
Cdd:TIGR02483 319 PIAEA 323
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 2-280 8.02e-99

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 306.96  E-value: 8.02e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   2 KKIAVLTSGGDSPGMNAAVRAVVRKAIYNNIEVYGIYQGYQGLLD--DNIHKLELGSVGDTIQRGGTFLYSARCPQFKEA 79
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDggDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  80 SVRQKGIENLHKRGIEGLVVVGGDGSYRGAQRISEE----------TKDIKT-----------IGIPGTIDNDINGTDFT 138
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEwpslleelvdTGKITAeqaeehrhltiVGLVGSIDNDMCGTDMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 139 IGFDTALNTIIDSVDKIRDTASSHARTFIVEVMGRDCGDLALWAGLSVGAETILVPEANTDIK---DIAEKIESGIKRGK 215
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGwedQLCHKLKRNRKAGK 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1091176342 216 KHSIVMVAEGSM-------SGQECADQLMKYINVDARVSVLGHIQRGGSPSGADRVLASRLGGYAVDLLMQG 280
Cdd:TIGR02478 241 RKTIVIVAEGAIdrdlnpiTSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLES 312
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 2-300 1.81e-88

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 280.56  E-value: 1.81e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   2 KKIAVLTSGGDSPGMNAAVRAVVRKAIYNNIEVYGIYQGYQGLLD--DNIHKLELGSVGDTIQRGGTFLYSARCPQFKEA 79
Cdd:cd00764     4 KAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKggDYIKQAEWESVSNWLQEGGTIIGSARCKEFRER 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  80 SVRQKGIENLHKRGIEGLVVVGGDGSYRGAQ-----------------RISEETKD----IKTIGIPGTIDNDINGTDFT 138
Cdd:cd00764    84 EGRLQAAYNLIQRGITNLCVIGGDGSLTGADlfrsewpslleelvkdgKITEEEVAkyqhLNIVGMVGSIDNDFCGTDMT 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 139 IGFDTALNTIIDSVDKIRDTASSHARTFIVEVMGRDCGDLALWAGLSVGAETILVPEANTDIK---DIAEKIESGIKRGK 215
Cdd:cd00764   164 IGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGwedQMCRRLSEHRSRGK 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 216 KHSIVMVAEGSMSGQ-------ECADQLMKYINVDARVSVLGHIQRGGSPSGADRVLASRLGGYAVDLLMQGRSGQG--- 285
Cdd:cd00764   244 RLNIIIVAEGAIDDQlkpitseDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTPacv 323

                         330
                  ....*....|....*
gi 1091176342 286 VGIMNNKLTATPFDE 300
Cdd:cd00764   324 VSLNGNKAVRLPLME 338
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
2-300 8.81e-81

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 249.22  E-value: 8.81e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   2 KKIAVLTSGGDSPGMNAAVRAVVRKAIYN-NIEVYGIYQGYQGLLDD--NIHKLELGSVGDTIQRGGTFL---------- 68
Cdd:PRK14071    5 KRIGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILgttnkgdpfa 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  69 YSARCPQFKEASvrQKGIENLHKRGIEGLVVVGGDGSYRGAQRISEEtKDIKTIGIPGTIDNDINGTDFTIGFDTALNTI 148
Cdd:PRK14071   85 FPMPDGSLRDRS--QEIIDGYHSLGLDALIGIGGDGSLAILRRLAQQ-GGINLVGIPKTIDNDVGATEVSIGFDTAVNIA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 149 IDSVDKIRDTASSHARTFIVEVMGRDCGDLALWAGLSVGAETILVPEANTDIKDIAEKIESGIKRGKKHSIVMVAEGSMS 228
Cdd:PRK14071  162 TEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTLENVCKKIRERQEEGKNFCLVVVSEAVRT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 229 --------------------GQECADQLMKYINVDARVSVLGHIQRGGSPSGADRVLASRLGGYAVDLLMQGRSGQGVGI 288
Cdd:PRK14071  242 eegeqvtktqalgedryggiGQYLAEQIAERTGAETRVTVLGHIQRGGIPSPRDRLLASAFGVAAVDLIAQGKFDRMVAW 321

                         330
                  ....*....|..
gi 1091176342 289 MNNKLTATPFDE 300
Cdd:PRK14071  322 QNRQVVSVPIAE 333
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 2-277 1.75e-57

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 197.56  E-value: 1.75e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   2 KKIAVLTSGGDSPGMNAAVRAVVRKAIYNNIEVYGIYQGYQGLLDDNIHKLELGSVGDTIQRGGTFLYSARCPQFKEASV 81
Cdd:TIGR02478 390 LRIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGT 469

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  82 RQKGIENLHkrgIEGLVVVGGDGSYRGAQRISEETKD-----IKTIGIPGTIDNDINGTDFTIGFDTALNTIIDSVDKIR 156
Cdd:TIGR02478 470 IAYYFQQHK---IDGLIIIGGFEAFEALYQLDAAREKypafrIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIK 546

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 157 DTAS-SHARTFIVEVMGRDCGDLALWAGLSVGAETILVPEANTDIKDIAEKIE---SGIKRGKKHSIVMVAEGSmSGQEC 232
Cdd:TIGR02478 547 QSASaSKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEhlkETFAEGRAGKLILRNEKA-SKVYT 625

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1091176342 233 ADQLMKYIN------VDARVSVLGHIQRGGSPSGADRVLASRLGGYAVDLL 277
Cdd:TIGR02478 626 TDFIARIISeegkgrFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFI 676
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 3-279 1.97e-48

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 172.70  E-value: 1.97e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   3 KIAVLTSGGDSPGMNAAVRAVVRKAIYNNIEVYGIYQGYQGLLDDNIHKLELGSVGDTIQRGGTFLYSARcpqfkeaSVR 82
Cdd:cd00764   391 NIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKR-------TLP 463

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  83 QKGIE----NLHKRGIEGLVVVGGDGSYRGAQRISEETKD-----IKTIGIPGTIDNDINGTDFTIGFDTALNTIIDSVD 153
Cdd:cd00764   464 KKDLEtiayNFQKYGIDGLIIVGGFEAYKGLLQLREAREQyeefcIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCD 543

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 154 KIRDTASS-HARTFIVEVMGRDCGDLALWAGLSVGAETILVPEANTDIKDI-------AEKIESGIKRGKKHSIVMVAEg 225
Cdd:cd00764   544 RIKQSASGtKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLqenvehlTEKMKTTIGRGLVLRNEKCNE- 622

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1091176342 226 sMSGQECADQLMKYI---NVDARVSVLGHIQRGGSPSGADRVLASRLGGYAVDLLMQ 279
Cdd:cd00764   623 -NYTTVFTYELYSEEgkgVFDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQ 678
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
 3-301 2.07e-47

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 165.60  E-value: 2.07e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   3 KIAVLTSGGDSPGMNAAVRAVVRKAIYN-NIE-VYGIYQGYQGLLDDNIHKLELGSVGDTIQRGGTFLYSARCPQFKEas 80
Cdd:PTZ00286   89 KAGIVTCGGLCPGLNVVIRELVMNLINNyGVKtIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTILGSSRGGFDPK-- 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  81 vrqKGIENLHKRGIEGLVVVGGDGSYRGAQRISEETK----DIKTIGIPGTIDNDINGTDFTIGFDTALNTIIDSVDKIR 156
Cdd:PTZ00286  167 ---VMVDTLIRHGINILFTLGGDGTHRGALAIYKELRrrklNISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAY 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 157 DTASSHARTF-IVEVMGRDCGDLALWAGLSVG-AETILVPEANTDIKDIAEKIESGIKRgKKHSIVMVAEGSMSGQECA- 233
Cdd:PTZ00286  244 VEAKSAKNGVgIVKLMGRDSGFIALHASVASAdVNVCLIPEFDIPLEGVLEYIEQRLQK-KGHCVIVVAEGAGQSLKDAd 322

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 234 ---------------------DQLMKYINVDARVSVLGHIQ-----RGGSPSGADRVLASRLGGYAVDLLMQGRSGQGVG 287
Cdd:PTZ00286  323 ldlgtdasgnkklwdigvylkDEITKYLKKKKPEHTVKYIDpsymiRAVPANAADAKFCTQLAQNAVHGAMAGFTGFIIG 402

                         330
                  ....*....|....
gi 1091176342 288 IMNNKLTATPFDEI 301
Cdd:PTZ00286  403 HVHNNYVMIPIKEM 416
PRK06830 PRK06830
ATP-dependent 6-phosphofructokinase;
3-299 5.16e-36

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235869  Cd Length: 443  Bit Score: 134.61  E-value: 5.16e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   3 KIAVLTSGGDSPGMNAAVRAVVRKA--IYNNIEVYGIYQGYQGLLDDNIHK-LELG--SVGDTIQRGGTFLYSARCPQFK 77
Cdd:PRK06830   82 KAAIVTCGGLCPGLNDVIRAIVLELhhHYGVRRILGIRYGYQGLIPRYGHDpVELTpeVVADIHEFGGTILGSSRGPQDP 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  78 EASVrqkgiENLHKRGIEGLVVVGGDGSYRGAQRISEETK----DIKTIGIPGTIDNDINGTDFTIGFDTAlntIIDSVD 153
Cdd:PRK06830  162 EEIV-----DTLERMNINILFVIGGDGTLRGASAIAEEIErrglKISVIGIPKTIDNDINFIQKSFGFETA---VEKATE 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 154 KIRDtASSHARTF-----IVEVMGRDCGDLALWAGLSVG-AETILVPEANTDI-------KDIAEKIESgikrgKKHSIV 220
Cdd:PRK06830  234 AIRC-AHVEANGApngigLVKLMGRHSGFIAAYAALASKdVNFVLIPEVPFDLegpngllAALEKRLAE-----RGHAVI 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 221 MVAEGsmSGQE-CADQ---------LMKYINVDARVSVLGHIQRGGSP-----------------SGADRVLASRLGGYA 273
Cdd:PRK06830  308 VVAEG--AGQElFDDTgetdasgnpKLGDIGLFLKDRIKEYFKARGIPinlkyidpsyiirsvpaNANDSVYCGFLGQNA 385

                         330       340
                  ....*....|....*....|....*.
gi 1091176342 274 VDLLMQGRSGQGVGIMNNKLTATPFD 299
Cdd:PRK06830  386 VHAAMAGKTGMVVGRWNNRFVHLPID 411
PLN02884 PLN02884
6-phosphofructokinase
 3-301 2.45e-27

6-phosphofructokinase


Pssm-ID: 178472 [Multi-domain]  Cd Length: 411  Bit Score: 110.29  E-value: 2.45e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   3 KIAVLTSGGDSPGMNAAVRAVVRK-AIYNNIEVYGIYQGYQGLLDDNIHKLEL--GSVGDTIQRGGTFLYSARC-PQFKE 78
Cdd:PLN02884   55 KAAIVTCGGLCPGLNDVIRQIVFTlEIYGVKNIVGIPFGYRGFFEKGLSEMPLsrKVVQNIHLSGGSLLGVSRGgAKTSD 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  79 AsvrqkgIENLHKRGIEGLVVVGGDGSYRGAQRISEETKDIK----TIGIPGTIDNDINGTDFTIGFDTAlntiIDSVDK 154
Cdd:PLN02884  135 I------VDSIEARGINMLFVLGGNGTHAGANAIHNECRKRKmkvsVVGVPKTIDNDILLMDKTFGFDTA----VEEAQR 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 155 IRDTASSHARTF-----IVEVMGRDCGDLALWAGLSVGAETI-LVPEA-------NTDIKDIAEKIESgikrgKKHSIVM 221
Cdd:PLN02884  205 AINSAYIEAHSAyhgigLVKLMGRSSGFIAMHASLASGQVDIcLIPEVpftldgpNGVLRHLEHLIET-----KGSAVVC 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 222 VAEGsmSGQECADQL----------MKYINVDARVSVLGHIQRGGSPS-----------------GADRVLASRLGGYAV 274
Cdd:PLN02884  280 VAEG--AGQDLLQKTnatdasgnpvLGDIGVHLQQEIKKHFKDIGVPAdvkyidptymiracranASDAILCTVLGQNAV 357

                         330       340
                  ....*....|....*....|....*..
gi 1091176342 275 DLLMQGRSGQGVGIMNNKLTATPFDEI 301
Cdd:PLN02884  358 HGAFAGFSGITVGICNTHYVYLPIPEV 384
PLN02564 PLN02564
6-phosphofructokinase
 3-301 4.38e-27

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 110.61  E-value: 4.38e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   3 KIAVLTSGGDSPGMNAAVRAVV--RKAIYNNIEVYGIYQGYQGLLDDNIHKLELGSVGDTIQRGGTFLYSARCPQFKeas 80
Cdd:PLN02564   89 RACIVTCGGLCPGLNTVIREIVcgLSYMYGVTRILGIDGGYRGFYSRNTIPLTPKVVNDIHKRGGTILGTSRGGHDT--- 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  81 vrQKGIENLHKRGIEGLVVVGGDGSYRGAQRISEETK----DIKTIGIPGTIDNDINGTDFTIGFDTALNTIIDSVDKIR 156
Cdd:PLN02564  166 --SKIVDSIQDRGINQVYIIGGDGTQKGASVIYEEIRrrglKVAVAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAAH 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 157 DTASS-HARTFIVEVMGRDCGDLALWAGL-SVGAETILVPEANTDIK---DIAEKIESGIKRgKKHSIVMVAEGsmSGQE 231
Cdd:PLN02564  244 VEAESvENGIGLVKLMGRYSGFIAMYATLaSRDVDCCLIPESPFYLEgkgGLFEFIEKRLKE-NGHMVIVVAEG--AGQD 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 232 CADQLMKYINV-DARVSVL-------------GHIQRGGS-----------------PSGA-DRVLASRLGGYAVDLLMQ 279
Cdd:PLN02564  321 LIAESMESSDLqDASGNKLlldvglwlsqkikDHFTKVKKmpinlkyidptymiraiPSNAsDNVYCTLLAHSAVHGAMA 400

                         330       340
                  ....*....|....*....|..
gi 1091176342 280 GRSGQGVGIMNNKLTATPFDEI 301
Cdd:PLN02564  401 GYTGFTVGPVNGRHAYIPFYRI 422
PRK14072 PRK14072
diphosphate--fructose-6-phosphate 1-phosphotransferase;
1-288 2.42e-21

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 237600 [Multi-domain]  Cd Length: 416  Bit Score: 93.39  E-value: 2.42e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   1 MKKIAVLTSGGDSPGMNAAVRAVVRKAI-YNNIE-VYGIYQGYQGLLDDNIHKLELGSVgDTIQR-----GGTFlYSARc 73
Cdd:PRK14072    3 KGNALYAQSGGPTAVINASAAGVIEEARkHKKIGkVYGARNGIIGILDEDLIDLSKESD-EALAAlahtpSGAL-GSCR- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  74 pqFKEASVR------QKGIENLHKRGIEGLVVVGGDGSYRGAQRISEETK----DIKTIGIPGTIDNDINGTDFTIGFDT 143
Cdd:PRK14072   80 --YKLKSLEedraeyERLLEVFKAHDIGYFFYNGGNDSMDTALKVSQLAKkmgyPIRCIGIPKTIDNDLPGTDHCPGFGS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 144 ALNTIIDSVDKI-RDTASSHA--RTFIVEVMGRDCGDLALWAGL-----SVGAETILVPEANTDIKDIAEKIESGIKRgK 215
Cdd:PRK14072  158 AAKYIATSVLEAaLDVAAMANtsKVFILEVMGRHAGWLAAAAALakqnpDDAPHLIYLPERPFDEEKFLADVRAIVKR-Y 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 216 KHSIVMVAEG------------------------SMSGQECADQLMKYINVDARVSVLGHIQR--GGSPSGADRVLASRL 269
Cdd:PRK14072  237 GYCVVVVSEGirdadgkfiaeaglaedafghaqlGGVAPVLANLIKEKLGKKVHWAVLDYLQRaaRHIASKTDVEEAYAV 316

                         330
                  ....*....|....*....
gi 1091176342 270 GGYAVDLLMQGRSGQGVGI 288
Cdd:PRK14072  317 GKAAVEYALAGKNGVMPAI 335
PTZ00287 PTZ00287
6-phosphofructokinase; Provisional
 3-225 1.64e-18

6-phosphofructokinase; Provisional


Pssm-ID: 240345 [Multi-domain]  Cd Length: 1419  Bit Score: 86.63  E-value: 1.64e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342    3 KIAVLTSGGDSPGMNAAVRAVVRKAI-YN-NIEVYGIYQGYQGLLDDNIHKLElGSVGDTIQRGGTF--LYSARcpqfke 78
Cdd:PTZ00287   179 KIGIILSGGPAPGGHNVISGIYDYAKrYNeQSQVIGFLGGIDGLYSKNYVTIT-DSLMNRFRNLGGFnmLWSGR------ 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   79 ASVRQK----GIENL-HKRGIEGLVVVGGDGSYRGAQRISEETKD----IKTIGIPGTIDNDIN--GTDFTIGFDTALNT 147
Cdd:PTZ00287   252 GKVRNKddliAIENIvAKLKLNGLVIIGGDGSNSNAALISEYFAErqipISIIGIPKTIDGDLKseAIEISFGFDTATKT 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  148 IIDSVDKI-RDTASSHARTFIVEVMGRDCGDLALWAGLSVGAETILVPEA----NTDIKDIAEKIESGI-KR---GKKHS 218
Cdd:PTZ00287   332 YSEVIGNLcTDVKTGHNVYHVVRVMGRSASHVVLECALQTRPNIVLIGEEvekeNLSLKDIVSNIVNTIlKRrslNKNYG 411


                   ....*..
gi 1091176342  219 IVMVAEG 225
Cdd:PTZ00287   412 VILIPEG 418
PRK07085 PRK07085
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
 2-225 4.51e-17

diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional


Pssm-ID: 235930  Cd Length: 555  Bit Score: 81.51  E-value: 4.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   2 KKIAVLTSGGDSPGMNAAVRAVVR--KAIYNNIEVYGIYQGYQGLLDDNIHKLELGSVGDTIQRGG-TFLYSARCP---- 74
Cdd:PRK07085   71 LKVGVILSGGQAPGGHNVIAGLFDglKKLNPDSKLFGFIGGPLGLLNGKYIEITEEVIDEYRNTGGfDMIGSGRTKiete 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  75 -QFkeasvrQKGIENLHKRGIEGLVVVGGDGSYRGAQRISE--ETKDIKT--IGIPGTIDNDINGT--DFTIGFDTALNT 147
Cdd:PRK07085  151 eQK------EACLETVKKLKLDGLVIIGGDDSNTNAAILAEyfAKHGCKTqvIGVPKTIDGDLKNEfiETSFGFDTATKT 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 148 IIDSVDKI-RDTASSHARTFIVEVMGRDCGDLALWAGLS-------VGAEtilVPEANTDIKDIAEKIESGI----KRGK 215
Cdd:PRK07085  225 YSEMIGNIsRDALSAKKYWHFIKLMGRSASHIALECALQthpniclISEE---VAEKKMSLQDIVHYIASVIadraAKGK 301

                         250
                  ....*....|
gi 1091176342 216 KHSIVMVAEG 225
Cdd:PRK07085  302 NYGVILIPEG 311
PTZ00468 PTZ00468
phosphofructokinase family protein; Provisional
 2-225 3.66e-14

phosphofructokinase family protein; Provisional


Pssm-ID: 185647 [Multi-domain]  Cd Length: 1328  Bit Score: 73.47  E-value: 3.66e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342    2 KKIAVLTSGGDSPGMNAAVRAVVR--KAIYNNIEVYGIYQGYQGLLDDNIHKLELGSVGDTIQRGGTFLYSARCPQFKEA 79
Cdd:PTZ00468   103 RRIGVVLSGGQASGGHNVIAGLMSyiKLCNQSSQLFGFLGGPEGVYSERYRELTEDDINGILNQGGFNIICSGRHKIETE 182

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   80 SVRQKGIENLHKRGIEGLVVVGGDGSYRGAQRISE----ETKDIKTIGIPGTIDNDING--TDFTIGFDTALNTIIDSVD 153
Cdd:PTZ00468   183 EQMRASLEICEKLKLHGLVVIGGDDSNTNAAVLAEyfkrNSSSTVVVGCPKTIDGDLKNevIETSFGYDTAVKTYSEQIG 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  154 KIRDTASSHA-RTFIVEVMGRDCGDLALWAGLSVGAETIL----VPEANTDIKDIAEKI-ESGIKR---GKKHSIVMVAE 224
Cdd:PTZ00468   263 SIMDAIKTEGyGYYFVRLMGRSASHITLECGLQTRANMILigeeIKEENRSLMSIVDEIvEMILKRdslGKKHGIVLLPE 342


                   .
gi 1091176342  225 G 225
Cdd:PTZ00468   343 G 343
Pyrophosphate_PFK cd00765
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 3-225 2.35e-10

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent phosphofructokinases. These are found in bacteria as well as plants. These may be dimeric nonallosteric enzymes as in bacteria or allosteric heterotetramers as in plants.


Pssm-ID: 238390  Cd Length: 550  Bit Score: 61.43  E-value: 2.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   3 KIAVLTSGGDSPGMNAAVRAVVR--KAIYNNIEVYGIYQGYQGLLDDNIHKLELGSVGDTIQRGGTFLYSARCPQFKEAS 80
Cdd:cd00765    74 KIGIVLSGGQAPGGHNVISGLFDylKERAKGSTLYGFKGGPAGILKCDYIELNAEYIQPYRNTGGFDMICSGRTKIETED 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  81 VRQKGIENLHKRGIEGLVVVGGDGSYRGAQRISEETKD----IKTIGIPGTIDNDINGTDFTI--GFDTALNTIIDSVDK 154
Cdd:cd00765   154 QFKQAEETAKKLDLDALVVIGGDDSNTNAALLAENFRSkglkTRVIGVPKTIDGDLKNKEIETsfGFDTATKIYSELIGN 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 155 I-RDTASSHARTFIVEVMGRDCGDLALWAGLSVGAETILVPE----ANTDIKDIAEKIESGI-KR---GKKHSIVMVAEG 225
Cdd:cd00765   234 VmRDARSTGKYWHFVKLMGRSASHIALECALKTHPNICIISEevsaQKQTLKNITDYMVDVIcKRaelGYNFGVVLVPEG 313
PRK06555 PRK06555
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
 1-304 1.40e-09

pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated


Pssm-ID: 180620 [Multi-domain]  Cd Length: 403  Bit Score: 58.48  E-value: 1.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   1 MKKIAVLTSGGDSPGMNAAVRAVVRK--AIYNNIEVYGIYQGYQGLLDDN--------------IHK----------LEL 54
Cdd:PRK06555    3 VKKVALLTAGGLAPCLSSAVGGLIERytEIAPEVEIIAYRSGYQGLLLGDsieitpavranaglLHRyggspignsrVKL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  55 GSVGDTIQRGgtflysarcpQFKEASVRQK-GIENLHKRGIEGLVVVGGDGSYRGAQRIS----EETKDIKTIGIPGTID 129
Cdd:PRK06555   83 TNVADCVKRG----------LVKEGENPLKvAAERLAADGVDILHTIGGDDTNTTAADLAaylaENGYDLTVVGLPKTID 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 130 NDINGTDFTIGFDTALNTIIDSVDKIRDTASSHARTFIV-EVMGRDCGDLAL--------------WA---GLSVGAETI 191
Cdd:PRK06555  153 NDVVPIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWLTAatarayrewldrqeYVpgfGLSAERWDI 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 192 ---LVPEANTDIKDIAEKIESGIKRGKKHSI---------VMVAEGSMSGQEC-------------------ADQLMKYI 240
Cdd:PRK06555  233 havYLPEMAFDLEAEAERLKAVMDEVGNVNIflsegagldAIVAEMEAAGEEVkrdafghvkldtinpgawfAKQFAELL 312

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1091176342 241 NVDaRVSVL--GHIQRGGSPSGADRVLASRLGGYAVDLLMQGRSGQgVG---IMNNKLTATPFDEIFNG 304
Cdd:PRK06555  313 GAE-KVMVQksGYFARSAPANAEDLRLIKSMVDLAVECALRGVSGV-IGhdeEQGGKLRAIEFPRIKGG 379
PLN02251 PLN02251
pyrophosphate-dependent phosphofructokinase
 3-225 5.09e-08

pyrophosphate-dependent phosphofructokinase


Pssm-ID: 215140  Cd Length: 568  Bit Score: 54.03  E-value: 5.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342   3 KIAVLTSGGDSPGMNAavravVRKAIYNNIE-------VYGIYQGYQGLLDDNIhkLELGSvgDTI-----QRGGTFLYS 70
Cdd:PLN02251   98 KIGVVLSGGQAPGGHN-----VISGIFDYLQehakgsvLYGFKGGPAGIMKCKY--VELTA--EFIypyrnQGGFDMICS 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  71 AR----CP-QFKEASvrqkgiENLHKRGIEGLVVVGGDGSYRGAQRISE--ETKDIKT--IGIPGTIDNDINGTDFTI-- 139
Cdd:PLN02251  169 GRdkieTPeQFKQAE------ETATKLDLDGLVVIGGDDSNTNACLLAEyfRAKNLKTrvIGCPKTIDGDLKSKEVPTsf 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342 140 GFDTALNTIIDSVDKIRDTASSHARTF-IVEVMGRDCGDLALWAGLS-------VGAEtilVPEANTDIKDIAEKIESGI 211
Cdd:PLN02251  243 GFDTACKIYSEMIGNVMIDARSTGKYYhFVRLMGRAASHITLECALQthpnitiIGEE---VAAKKLTLKNVTDYIVDVI 319

                         250
                  ....*....|....*...
gi 1091176342 212 -KR---GKKHSIVMVAEG 225
Cdd:PLN02251  320 cKRaelGYNYGVILIPEG 337
PLN03028 PLN03028
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
 94-225 2.95e-06

pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Provisional


Pssm-ID: 215543  Cd Length: 610  Bit Score: 48.62  E-value: 2.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1091176342  94 IEGLVVVGGDGSYRGAQRISE---ETK-DIKTIGIPGTIDNDING--TDFTIGFDTA--LNT-IIDSVdkIRDTASSHAR 164
Cdd:PLN03028  174 LDGLVIIGGVTSNTDAAQLAEtfaEAKcKTKVVGVPVTLNGDLKNqfVETNVGFDTIckVNSqLISNV--CTDALSAEKY 251

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1091176342 165 TFIVEVMGRDCGDLALWAGLSVGAETILVPE--ANTD--IKDIAEKIESGIK----RGKKHSIVMVAEG 225
Cdd:PLN03028  252 YYFIRLMGRKASHVALECALQSHPNMVILGEevAASKltLFDITKQICDAVQaraeQDKNHGVILIPEG 320
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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